|
TMPY-02431
|
BCL-XL Protein, Human, Recombinant (His)
bcl-xS,PPP1R52,Bcl-X,BCLXL,BC...
|
Human
|
E. coli
|
|
B-cell lymphoma-extra large (Bcl-xl) is a transmembrane molecule in the mitochondria. Bcl-xL (BCL2L1), belongs to the Bcl-2 family. Members of the bcl-2 family encode proteins that function either to promote or to inhibit apoptosis. Antiapoptotic members such as Bcl-2 and Bcl-xL prevent PCD in response to a wide variety of stimuli to take part in cancer survival. Conversely, proapoptotic proteins, exemplified by Bax and Bak, can accelerate death and in some instances are sufficient to cause apop... |
|
TMPY-02700
|
BCL2 Protein, Human, Recombinant (His)
Bcl-2,PPP1R50,B-cell CLL/lymphoma 2
|
Human
|
E. coli
|
|
BCL2 (B-cell leukemia/lymphoma 2, N-Histidine-tagged), also known as Bcl-2, belongs to the Bcl-2 family. Bcl-2 family proteins regulate and contribute to programmed cell death or apoptosis. It is a large protein family and all members contain at least one of four BH (bcl-2 homology) domains. Certain members such as Bcl-2, Bcl-xl and Mcl1 are anti-apoptotic, whilst others are pro-apoptotic. Most Bcl-2 family members contain a C-terminal transmembrane domain that functions to target these proteins... |
|
TMPY-02564
|
BCL-XL Protein, Mouse, Recombinant (aa 1-212, His)
bcl2-L-1,Bcl-XL,BCL2-like 1,B...
|
Mouse
|
E. coli
|
|
B-cell lymphoma-extra large (Bcl-xl) is a transmembrane molecule in the mitochondria. Bcl-xL (BCL2L1), belongs to the Bcl-2 family. Members of the bcl-2 family encode proteins that function either to promote or to inhibit apoptosis. Antiapoptotic members such as Bcl-2 and Bcl-xL prevent PCD in response to a wide variety of stimuli to take part in cancer survival. Conversely, proapoptotic proteins, exemplified by Bax and Bak, can accelerate death and in some instances are sufficient to cause apop... |
|
TMPY-02004
|
BCL-W Protein, Human, Recombinant (His)
BCL2-L-2,BCL-W,BCL2-like 2,BC...
|
Human
|
E. coli
|
|
Beta1,4-Galactosyltransferase-I (B4GALT1), one of seven beta1,4-galactosyltransferases, is an enzyme commonly found in the trans-Golgi complex that adds galactose to oligosaccharides. They have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and be... |
|
TMPH-03245
|
BCL2 Protein, Rat, Recombinant (His)
Bcl2,Apoptosis regulator Bcl-2,Bcl
|
Rat
|
in vitro E. coli expression system
|
|
Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). Also acts as an inhibitor of autophagy: interacts with BECN1 and AMBRA1 during non-star... |
|
TMPH-02520
|
BCL2 Protein, Mouse, Recombinant (His)
Bcl2,Apoptosis regulator Bcl-2,Bcl
|
Mouse
|
E. coli
|
|
Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). Also acts as an inhibitor of autophagy: interacts with BECN1 and AMBRA1 during non-star... |
|
TMPH-01001
|
BCL10 Protein, Human, Recombinant (His & SUMO)
B-cell lymphoma/leukemia 10,cCARMEN,hCLAP,CIPER,CLAP,BCL...
|
Human
|
E. coli
|
|
Plays a key role in both adaptive and innate immune signaling by bridging CARD domain-containing proteins to immune activation. Acts by channeling adaptive and innate immune signaling downstream of CARD domain-containing proteins CARD9, CARD11 and CARD14 to activate NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines. Recruited by activated CARD domain-containing proteins: homooligome... |
|
TMPH-00999
|
BCL6 Protein, Human, Recombinant (His)
BCL-5,B-cell lymphoma 5 protein,BCL5,Zinc ...
|
Human
|
E. coli
|
|
BCL6 Protein, Human, Recombinant (His) is expressed in E. coli. |
|
TMPH-01000
|
BCL6 Protein, Human, Recombinant
ZNF51,LAZ3,ZBTB27,Zinc finger protein 51,BCL6,B...
|
Human
|
E. coli
|
|
BCL6 Protein, Human, Recombinant is expressed in E. coli. |
|
TMPJ-00584
|
Bc1-w Protein, Human, Recombinant (His)
Apoptosis Regulator Bcl-W,KIAA0271,Bcl-2-L...
|
Human
|
E. coli
|
|
Bcl-2-like protein 2 (BCL2L2) belongs to the Bcl-2 family. BCL2L2 is highly expressed in thebrain, spinal cord, testis, pancreas, heart, spleen, and mammary glands. BCL2L2 is a peripheral membrane protein containing three motifs, BH1, BH2 and BH4. The BH4 motif appears to be involved in the anti-apoptotic function. The BH1 and BH2 motifs form a hydrophobic groove which acts as a docking site for the BH3 domain of some pro-apoptotic proteins. BCL2L2 promotes cell survival and blocks dexamethasone... |
|
TMPH-02534
|
BAG3 Protein, Mouse, Recombinant (His)
Bcl-2-associated athanogene 3,Bag3,Bcl-2-b...
|
Mouse
|
Yeast
|
|
Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70. Has anti-apoptotic activity. Plays a role in the HSF1 nucleocytoplasmic tr... |
|
TMPH-02535
|
BAG3 Protein, Mouse, Recombinant (His & SUMO)
Bcl-2-associated athanogene 3,Bis,BAG-3,BAG family ...
|
Mouse
|
E. coli
|
|
Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70. Has anti-apoptotic activity. Plays a role in the HSF1 nucleocytoplasmic tr... |
|
TMPJ-00717
|
BAG2 Protein, Human, Recombinant (His)
BAG-2,BAG Family Molecular Chaperone Regulator 2,BAG2,Bc...
|
Human
|
E. coli
|
|
BAG Family Molecular Chaperone Regulator 2 (BAG2) is a member of the Bag family whose members compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. BAG2 contains 1 BAG domain and is a important component of the HSC 70/CHIP chaperone-dependent ubiquitin ligase complex. In mammalian cells BAG1, BAG2, and BAG3 bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. |
|
TMPY-02430
|
BCL6 Protein, Human, Recombinant (aa 1-150, His & Trx)
BCL5,ZNF51,B-cell CLL/lymphoma 6,LAZ3,ZBTB27,BC...
|
Human
|
E. coli
|
|
The protein encoded by this gene is an evolutionarily conserved 95-kDa protein containing six C-terminal zinc-finger motifs and an N-terminal POZ domain. It has been reported that BCL-6 is present in DNA-binding complexes in nuclear extracts from various B-cell lines. There are many relationships between non-Hodgkin's lymphoma, diffuse large cell lymphoma and BCL6’s translocations. BCL6 can repress transcription from promoters linked to its DNA target sequence and this activity is dependent upon... |
|
TMPH-01359
|
CCND1 Protein, Human, Recombinant (His)
CCND1,BCL-1,B-cell lymphoma 1 protein,PRAD1,G1/S-sp...
|
Human
|
E. coli
|
|
Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are ma... |
|
TMPH-03509
|
Simian immunodeficiency virus (SIV) (isolate PBj14/BCL-3) Vpx Protein (His & SUMO)
|
SIV
|
E. coli
|
|
Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells. Targets specific host proteins for degradation by the 26S proteasome. Acts by associating with the cellular CUL4A-DDB1 E3 ligase complex through direct interaction with host VPRPB/DCAF-1. This change in the E3 ligase substrate specificity results in the degradation of host SAMHD1. In turn, SAMHD1 depletion allows viral replication in host myeloid cells by... |
|
TMPY-04936
|
BCL2A1 Protein, Human, Recombinant (His)
BFL1,ACC1,ACC-2,GRS,ACC-1,HBPA1,BCL2 related protei...
|
Human
|
E. coli
|
|
B-cell lymphoma 2-related protein A1 (BCL2A1) is a member of the BCL-2 family of anti-apoptotic proteins that confers resistance to treatment with anti-cancer drugs. Immunohistochemical expression of Wnt11 and BCL2A1 in complete moles and normal villi. Bcl2 family proteins control mitochondrial apoptosis and its members exert critical cell type and differentiation stage-specific functions, acting as barriers against autoimmunity or transformation. Anti-apoptotic Bcl2a1/Bfl1/A1 is frequently der... |
|
TMPY-03748
|
BCL2L12 Protein, Human, Recombinant (GST)
BCL2-like 12 (proline rich)
|
Human
|
E. coli
|
|
BCL2-like 12 (BCL2L12 ) is a new member of the apoptosis-related BCL2 gene family, members of which are implicated in various malignancies. The mRNA expression of BCL2L12 may constitute a novel biomarker for the prediction of short-term relapse in nasopharyngeal carcinoma. BCL2L12 is a recently identified gene belonging to the BCL2 family, members of which are implicated in hematologic malignancies, including chronic lymphocytic leukemia (CLL). BCL2L12 can be considered as a new independent prog... |
|
TMPY-06842
|
BMP-4 Protein, Human, Recombinant (E399D)
OFC11,BMP2B,bone morphogenetic protein 4,BMP2B1,ZYME,MCOPS6
|
Human
|
E. coli
|
|
BMP4 (bone morphogenetic protein-4)-directed differentiation of human embryonic stem cells (ESCd). Autophagy is a conserved catabolic process with complicated roles in tumor development. Bone morphogenetic protein 4 (BMP4), a member of the transforming growth factor (TGF-β) family of regulatory proteins, plays a crucial role in human malignancies. BMP4 treatment promoted HCC cells proliferation and induced autophagy. Mechanistic study revealed that the induction of autophagy by BMP4 was mediated... |
|
TMPY-04052
|
IL-17RB Protein, Human, Recombinant (His)
interleukin 17 receptor B,IL17RH1,CRL4,IL17BR,EVI27
|
Human
|
HEK293
|
|
IL17RB (Interleukin 17 Receptor B) is a Protein Coding gene. IL17RB is the receptor for IL17E, the only member of the IL17 family promoting Th2 reactions. IL17RB is induced on human macrophages by IL4 and enhanced by TGFbeta. Overexpression of IL17RB is associated with poor prognosis and the short survival of breast cancer patients.IL17RB/IL17B signaling triggers a substantial increase in cell growth, proliferation, and migration through the activation of NF-kappaB as well as the up-regulation o... |
|
TMPJ-00038
|
IL-7 Protein, Mouse, Recombinant (His)
interleukin-7,白介素,IL-7,IL-7 interleukin-7,PBGF,Lymphopoietin...
|
Mouse
|
Human Cells
|
|
Mouse interleukin-7(IL-7) is the member of hemopoietin family which is important to the differentiation, proliferation, and survival of lymphocyte. Mouse IL-7 shares approximately 88% aa sequence identity with rat IL-7 and 58-60% with human, equine, bovine, ovine, porcine, feline and canine IL-7. It is widely expressed in primary and secondary lymphoid tissues cell and stromal epithelial cells of the thymus, bone marrow, and intestines. IL-7 activation of IL-7 R alpha is critical for both T cell... |
|
TMPY-02603
|
STAT6 Protein, Human, Recombinant (His)
STAT6C,IL-4-STAT,STAT6B,signal transducer and activator of t...
|
Human
|
Baculovirus-Insect Cells
|
|
Signal transducer and activator of transcription 6 (STAT6) is a transcription factor that is activated by interleukin-4 (IL-4)-induced tyrosine phosphorylation and mediates most of the IL-4-induced gene expression. STAT6 plays a central role in exerting interleukin-4 (IL-4) mediated biological responses and is found to induce the expression of BCL2L1/BCL-XL, which is responsible for the anti-apoptotic activity of IL4. Transcriptional activation by STAT6 requires the interaction with coactivators... |
|
TMPY-04632
|
IL-15 Protein, Human, Recombinant
白细胞介素,IL-15,白介素,interleukin 15
|
Human
|
E. coli
|
|
The protein encoded by the IL15 gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietic receptor subunits and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as ... |
|
TMPY-03974
|
Bim Protein, Human, Recombinant (His)
BAM,BCL2-like 11 (apoptosis facilitator),BIM,BOD
|
Human
|
E. coli
|
|
BCL2L11, also known as Bim, belongs to the BCL-2 protein family. Members of this family form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. BCL2L11 contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and to act as an apoptotic activator. BCL2L11 gene functions as an essential initiator of apoptosis in thymoc... |
|
TMPK-00636
|
BID Protein, Mouse, Recombinant (His)
BID,p22 BID
|
Mouse
|
E. coli
|
|
Bid, BH3-interacting domain death agonist, was initially cloned based in its ability to interact with both Bcl-2 and Bax. Bid contains only the BH3 domain, which is required for its interaction with the Bcl-2 family proteins and for its pro-death activity. Bid is susceptible to proteolytic cleavage by caspases, calpains, Granzyme B and cathepsins. Bid is important to cell death mediated by these proteases and thus is the sentinel to protease-mediated death signals. |
|
TMPH-00535
|
Epstein-Barr virus (strain B95-8) BHRF1 Protein (His)
|
EBV
|
E. coli
|
|
Prevents premature death of the host cell during virus production, which would otherwise reduce the amount of progeny virus. Acts as a host B-cell leukemia/lymphoma 2 (Bcl-2) homolog, and interacts with pro-apoptotic proteins to prevent mitochondria permeabilization, release of cytochrome c and subsequent apoptosis of the host cell. |
|
TMPY-02001
|
RTN4 Protein, Human, Recombinant (GST)
UNG1,NOGO,reticulon 4,RTN4-A,Nbla00271,NOGO-A,RTN-X,NSP,UNG1...
|
Human
|
E. coli
|
|
Reticulon-4, also known as Foocen, Neurite outgrowth inhibitor, Nogo protein, Neuroendocrine-specific protein, Neuroendocrine-specific protein C homolog, RTN-x, Reticulon-5 and RTN4, is a multi-pass membrane protein that contains one reticulon domain. Isoform 1 of RTN4 is specifically expressed in brain and testis and weakly in heart and skeletal muscle. Isoform 2 of RTN4 is widely expressed except for the liver. Isoform 3 of RTN4 is expressed in brain, skeletal muscle and adipocytes. Isoform 4 ... |
|
TMPY-02065
|
BID Protein, Mouse, Recombinant (His & GST)
AU022477,BH3 interacting domain death agonist,2700049M22Rik,...
|
Mouse
|
E. coli
|
|
The BH3 interacting domain death agonist (BID) is a pro-apoptotic member of the Bcl-2 protein family, which contains only the BH3 domain, and is required for its interaction with the Bcl-2 family proteins and for its pro-death activity. BID is important to cell death mediated by these proteases and thus is the sentinel to protease-mediated death signals. Recent studies further indicate that Bid may be more than just a killer molecule, it could be also involved in the maintenance of genomic stabi... |
|
TMPY-02027
|
BID Protein, Human, Recombinant
BH3 interacting domain death agonist,FP497
|
Human
|
E. coli
|
|
The BH3 interacting domain death agonist (BID) is a pro-apoptotic member of the Bcl-2 protein family, which contains only the BH3 domain, and is required for its interaction with the Bcl-2 family proteins and for its pro-death activity. BID is important to cell death mediated by these proteases and thus is the sentinel to protease-mediated death signals. Recent studies further indicate that Bid may be more than just a killer molecule, it could be also involved in the maintenance of genomic stabi... |
|
TMPY-04768
|
PRPS2 Protein, Human, Recombinant (His)
PRPS2,PRSII,phosphoribosyl pyrophosphate synthetase 2
|
Human
|
E. coli
|
|
PRPS2, a subset of PRS, is reported to be a potential protein associated with Sertoli-cell only syndrome. PRPS2 expression correlates with Sertoli-cell only syndrome and inhibits the apoptosis of TM4 Sertoli cells via the p53/Bcl-2/caspases signaling pathway. The gene for PRS II (PRPS2) is located at a different region of the X chromosome, namely Xpter-a21. The promoter region of the human PRPS2 gene was also GC-rich and contained a TATA-like sequence, four Sp1 binding sites and a homopyrimidine... |
|
TMPY-00431
|
BMP-4 Protein, Mouse, Recombinant (rFc)
bone morphogenetic protein 4,Bmp-4,Bmp2b-1,Bmp2b,Bmp2b1
|
Mouse
|
HEK293
|
|
BMP4 (bone morphogenetic protein-4)-directed differentiation of human embryonic stem cells (ESCd). Autophagy is a conserved catabolic process with complicated roles in tumor development. Bone morphogenetic protein 4 (BMP4), a member of the transforming growth factor (TGF-β) family of regulatory proteins, plays a crucial role in human malignancies. BMP4 treatment promoted HCC cells proliferation and induced autophagy. Mechanistic study revealed that the induction of autophagy by BMP4 was mediated... |
|
TMPY-04162
|
IL-17RB Protein, Mouse, Recombinant (hFc)
IL-17Rh1,IL17RH1,interleukin 17 receptor B,Evi27,Il17br,IL-1...
|
Mouse
|
HEK293
|
|
IL17RB (Interleukin 17 Receptor B) is a Protein Coding gene. IL17RB is the receptor for IL17E, the only member of the IL17 family promoting Th2 reactions. IL17RB is induced on human macrophages by IL4 and enhanced by TGFbeta. Overexpression of IL17RB is associated with poor prognosis and the short survival of breast cancer patients.IL17RB/IL17B signaling triggers a substantial increase in cell growth, proliferation, and migration through the activation of NF-kappaB as well as the up-regulation o... |
|
TMPY-00352
|
IL-17RB Protein, Rhesus, Recombinant (His)
interleukin 17 receptor B
|
Rhesus
|
HEK293
|
|
IL17RB (Interleukin 17 Receptor B) is a Protein Coding gene. IL17RB is the receptor for IL17E, the only member of the IL17 family promoting Th2 reactions. IL17RB is induced on human macrophages by IL4 and enhanced by TGFbeta. Overexpression of IL17RB is associated with poor prognosis and the short survival of breast cancer patients.IL17RB/IL17B signaling triggers a substantial increase in cell growth, proliferation, and migration through the activation of NF-kappaB as well as the up-regulation o... |
|
TMPJ-00455
|
SLAMF5 Protein, Mouse, Recombinant (His)
CD84 molecule,SLAM family member 5,Leukocyte differentiation...
|
Mouse
|
Human Cells
|
|
CD84, also called SLAMF5, is a member of the CD2 subgroup of the immunoglobulin receptor superfamily. Members of this CD2 subgroup mediate signal transduction through the interaction of its immunoreceptor tyrosine-based switch motifs (ITSM) in the intracellular region and the SH2 domain of adaptor molecules SAP (SLAM-associated protein) and EAT-2 (EWS-activated transcript 2), and accordingly modulate both adaptive and innate immune responses. CD84 expression has been documented on several hemato... |
|
TMPJ-01066
|
CYCS Protein, Human, Recombinant (His)
CYC,Cytochrome C,CYCS
|
Human
|
E. coli
|
|
Cytochrome C (CYCS) is a small heme protein that belongs to the cytochrome c family. It is found loosely associated with the inner membrane of the mitochondrion. Cytochrome C is a highly soluble protein that functions as a central component of the electron transport chain in mitochondria. CYCS transfers electrons between Complexes III (Coenzyme Q - Cyt C reductase) and IV (Cyt C oxidase). CYCS plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic... |
|
TMPY-03471
|
IL-17RB Protein, Mouse, Recombinant (His)
interleukin 17 receptor B,IL-17Rh1,IL-17ER,Il17br,Evi27,IL17...
|
Mouse
|
HEK293
|
|
IL17RB (Interleukin 17 Receptor B) is a Protein Coding gene. IL17RB is the receptor for IL17E, the only member of the IL17 family promoting Th2 reactions. IL17RB is induced on human macrophages by IL4 and enhanced by TGFbeta. Overexpression of IL17RB is associated with poor prognosis and the short survival of breast cancer patients.IL17RB/IL17B signaling triggers a substantial increase in cell growth, proliferation, and migration through the activation of NF-kappaB as well as the up-regulation o... |
|
TMPY-03850
|
IL-17RB Protein, Human, Recombinant (hFc)
IL17RH1,CRL4,interleukin 17 receptor B,IL17BR,EVI27
|
Human
|
HEK293
|
|
IL17RB (Interleukin 17 Receptor B) is a Protein Coding gene. IL17RB is the receptor for IL17E, the only member of the IL17 family promoting Th2 reactions. IL17RB is induced on human macrophages by IL4 and enhanced by TGFbeta. Overexpression of IL17RB is associated with poor prognosis and the short survival of breast cancer patients.IL17RB/IL17B signaling triggers a substantial increase in cell growth, proliferation, and migration through the activation of NF-kappaB as well as the up-regulation o... |
|
TMPY-04706
|
IL-17RB Protein, Rhesus, Recombinant (hFc)
interleukin 17 receptor B
|
Rhesus
|
HEK293
|
|
IL17RB (Interleukin 17 Receptor B) is a Protein Coding gene. IL17RB is the receptor for IL17E, the only member of the IL17 family promoting Th2 reactions. IL17RB is induced on human macrophages by IL4 and enhanced by TGFbeta. Overexpression of IL17RB is associated with poor prognosis and the short survival of breast cancer patients.IL17RB/IL17B signaling triggers a substantial increase in cell growth, proliferation, and migration through the activation of NF-kappaB as well as the up-regulation o... |
|
TMPY-04049
|
IL-15 Protein, Human, Recombinant (His)
interleukin 15,白细胞介素,白介素,IL-15
|
Human
|
E. coli
|
|
The protein encoded by the IL15 gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietic receptor subunits and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as ... |
|
TMPY-04417
|
DAPK1 Protein, Human, Recombinant (aa 1-363, His & GST)
DAPK,death-associated protein kinase 1,ROCO3
|
Human
|
Baculovirus-Insect Cells
|
|
Death-associated protein kinase 1, also known as DAP kinase 1, DAPK1 and DAPK, is a cytoplasm protein which belongs to theprotein kinase superfamily, CAMK Ser / Thr protein kinase family and DAP kinase subfamily. DAPK1 contains tenANK repeats, onedeath domain and oneprotein kinase domain. DAPK1 is a calcium / calmodulin-dependent serine/threonine kinase which acts as a positive regulator of apoptosis. DAPK1 gene is a candidate tumor suppressor (TSG) and the abnormal methylation of DAPK1 g... |
|
TMPJ-00681
|
EDIL3 Protein, Human, Recombinant (His)
EGF-Like Repeats and Discoidin I-Like Domains 3,EDIL3
|
Human
|
Human Cells
|
|
EGF-Like Repeat and Discoidin I-Like Domain-Containing Protein 3 (EDIL3) is a 52 kDa extracellular matrix protein that is expressed by endothelial tissues during embryonic vascular development. EDIL3 becomes quiescent at the time of birth, and is no longer expressed in normal adult tissues. EDIL3 has been found to be re-expressed in a number of human tumors as well as in ischemic muscles and ischemic brain tissue, which may play an important role in adult angiogenesis. EDIL3 promotes adherence a... |
|
TMPY-01824
|
Caspase-14 Protein, Human, Recombinant (His)
caspase 14, apoptosis-related cysteine peptidase,ARCI12
|
Human
|
E. coli
|
|
Caspase 14 is a member of the caspase family. Caspases are a kind of cysteine proteinase consisting of a prodomain plus large and small catalytic subunits, that play a central role in cell apoptosis. Caspase 14 possesses an unusually short prodomain and is highly expressed in embryonic tissues but absent from most of the adult tissues except for the skin, which suggests a role in ontogenesis and skin physiology. Unlike the other short prodomain caspases(caspase-3, caspase-6, and caspase-7), Casp... |
|
TMPY-03795
|
EIF5A2 Protein, Human, Recombinant (His)
eIF5AII,eukaryotic translation initiation factor 5A2,EIF-5A2
|
Human
|
E. coli
|
|
Eukaryotic translation initiation factor 5A2 (EIF5A2) has been demonstrated to be upregulated in numerous types of human cancer and is associated with cancer progression. Silencing of EIF5A2 in the NSCLC cells resulted in the downregulation of the tumorigenic proteins, apoptosis regulator Bcl-2 and myc proto-oncogene protein, and upregulation of E-cadherin, suggesting that EIF5A2 promotes proliferation and metastasis through these proteins. EIF5A2 may therefore serve as a novel therapeutic targe... |
|
TMPH-02574
|
p53 Protein, Mouse, Recombinant (His & SUMO)
|
Mouse
|
E. coli
|
|
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 ex... |
|
TMPH-03264
|
p53 Protein, Rat, Recombinant (His)
|
Rat
|
E. coli
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Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 ex... |
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TMPY-04084
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ANGPTL1 Protein, Canine, Recombinant (hFc)
angiopoietin-like 1
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Canine
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HEK293
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Angiopoietin-like protein 1 (ANGPTL1) has been reported to suppress migration and invasion in lung and breast cancer, acting as a novel tumor suppressor candidate. Downregulation of tumor suppressor signaling plays an important role in the pathogenesis of hepatocellular carcinoma (HCC).The downregulation of the angiopoietin-like protein ANGPTL1 is associated with vascular invasion, tumor thrombus, metastasis, and poor prognosis in HCC. Ectopic expression of ANGPTL1 in HCC cells effectively decre... |
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TMPH-01255
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DNM1L Protein, Human, Recombinant (His & Myc)
Dynamin-like protein IV,Dynamin-related protein 1,DLP1,Dympl...
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Human
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E. coli
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Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism. The specific recruitment at scission sites is mediated by membrane receptors like MFF, MIEF1 and MIEF2 for mitochondrial membranes. While the recruitment by the membrane receptors is GTP-dependent, the following hydrolysis... |
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TMPH-01075
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p53 Protein, Human, Recombinant (His & SUMO)
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Human
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E. coli
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Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 ex... |
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