store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
S63845 是一种选择性骨髓细胞白血病 1 抑制剂,结合人 MCL1的 Kd 值为 0.19 nM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 796 | 现货 | ||
5 mg | ¥ 2,730 | 现货 | ||
10 mg | ¥ 4,160 | 现货 | ||
25 mg | ¥ 6,520 | 现货 | ||
50 mg | ¥ 8,790 | 现货 | ||
100 mg | ¥ 11,800 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 3,380 | 现货 |
产品描述 | S63845 is a selective MCL-1 inhibitor(Kd: 0.19 nM) |
靶点活性 | MCL1:0.19 nM (Kd) |
体外活性 | S63845, a small molecule that specifically binds with high affinity to the BH3-binding groove of MCL1.?S63845 potently kills MCL1-dependent cancer cells, including multiple myeloma, leukaemia and lymphoma cells, by activating the BAX/BAK-dependent mitochondrial apoptotic pathway[1]. |
体内活性 | In vivo, S63845 shows potent anti-tumour activity with an acceptable safety margin as a single agent in several cancers.?Moreover, MCL1 inhibition, either alone or in combination with other anti-cancer drugs, proved effective against several solid cancer-derived cell lines.?MCL1 as a target for the treatment of a wide range of tumours[1]. |
分子量 | 829.26 |
分子式 | C39H37ClF4N6O6S |
CAS No. | 1799633-27-4 |
store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 33.33 mg/mL (40.19 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.2059 mL | 6.0295 mL | 12.0589 mL | 30.1474 mL |
5 mM | 0.2412 mL | 1.2059 mL | 2.4118 mL | 6.0295 mL | |
10 mM | 0.1206 mL | 0.6029 mL | 1.2059 mL | 3.0147 mL | |
20 mM | 0.0603 mL | 0.3015 mL | 0.6029 mL | 1.5074 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
S63845 1799633-27-4 Apoptosis BCL S 63845 Inhibitor S-63845 Bcl-2 Family inhibit inhibitor