271
25
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T12715 |
Reverse transcriptase-IN-1
|
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Reverse transcriptase-IN-1 是一种二芳基苯并嘧啶类似物,是一种有效的 HIV-1 非核苷类逆转录酶抑制剂,IC50 为 13.7 nM。 | |||
T7578 |
REVERSE T3
碘塞罗宁,3,3',5'-triiodo-L-thyronine |
Thyroid hormone receptor(THR) | Endocrinology/Hormones |
Reverse T3 (3,3',5'-triiodo-L-thyronine) 是由甲状腺素原脱碘后产生的甲状腺激素。它可抑制由其它甲状腺激素类似物引起的新生大鼠心肌细胞中钠电流增加的作用。 | |||
T72206 | Reverse transcriptase-IN-4 | ||
Reverse transcriptase-IN-4 是一种有效的选择性非核苷类逆转录酶 (NNRT) 抑制剂,作用于野生型HIV-1的EC50值为 0.053 μM,作用于HIV-1突变株 E138K 的EC50值为 0.26 μM。 | |||
T72203 |
Reverse transcriptase-IN-3
|
||
Reverse transcriptase-IN-3, 作为一种嘧啶-5-羧酰胺衍生物,主要用于抑制HIV-1。它对HIV-1野生型及其突变型病毒株均展示出高效的抑制活性。 | |||
T7447 |
Adefovir
|
HBV; Reverse Transcriptase; Telomerase | DNA Damage/DNA Repair; Microbiology/Virology |
Adefovir 是一种单磷酸腺苷类似物抗病毒剂,在细胞内转化为 Adefovir diphosphate 后可抑制HBVDNA 聚合酶。它在 HepG2.2.15 细胞系中对HBV 的IC50为 0.7 μM。它对多种病毒(包括HBV 和疱疹病毒)具有良好的抗病毒活性。 | |||
T12609 |
R-10015
|
LIM Kinase; Reverse Transcriptase | Cell Cycle/Checkpoint; Microbiology/Virology |
R-10015 是一种高效选择性 LIMK 抑制剂,通过结合 ATP 结合口袋阻断 LIMK,抑制人 LIMK1 的 IC50值为 38 nM。它还发挥广谱抗病毒作用,可用于 HIV 感染研究。 | |||
T16530 |
BF738735
|
Antiviral; PI4K | Immunology/Inflammation; PI3K/Akt/mTOR signaling |
BF738735 是有效的磷脂酰肌醇 4-激酶 IIIβ 抑制剂,IC50为 5.7 nM。 | |||
T9223 |
RO-0335
|
Reverse Transcriptase | Microbiology/Virology |
RO-0335 是新高效二苯醚非核苷逆转录酶抑制剂。它 (IC50= 1.1 nM) 可以抑制Wt HIV-1病毒,对 92% 的 NNRTI 耐药临床分离株具有保留活性 (IC50<100 nM)。 | |||
T16098 |
Islatravir
MK-8591 |
HIV Protease; Reverse Transcriptase | Microbiology/Virology; Proteases/Proteasome |
Islatravir (MK-8591) 是一种核苷逆转录酶抑制剂,是抗HIV-1药物,对 HIV-1 (WT),HIV-1 (M184V),HIV-1 (MDR) 的EC50值分别为 0.068 nM,3.1 nM 和 0.15 nM。 | |||
T10133 |
3'-Azido-3'-deoxy-5-methylcytidine
|
Antiviral; HIV Protease | Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome |
3'-Azido-3'-deoxy-5-methylcytidine 抑制 HIV-1 逆转录酶 (EC50 = 0.06 μM),是异嗜性鼠白血病相关逆转录病毒 (XMRV, CC50 = 43.5 μM) 的有效抑制剂。 | |||
T6214 |
Emtricitabine
恩曲他滨,FTC,Emtriva,BW1592 |
HIV Protease; Reverse Transcriptase | Microbiology/Virology; Proteases/Proteasome |
Emtricitabine (FTC) 是一种核苷逆转录酶抑制剂, 在 PBMC 细胞中的 EC50值为0.01 µM,可研究 HIV 感染。 | |||
T2330 |
Rilpivirine
TMC278,R278474,利匹韦林,DB08864 |
HIV Protease; Reverse Transcriptase | Microbiology/Virology; Proteases/Proteasome |
Rilpivirine (R278474) 是一种二芳基嘧啶衍生物和非核苷逆转录酶抑制剂,具有抗 HIV-1 的抗病毒活性,用于治疗 HIV 感染。 | |||
T7700 |
Lersivirine
3-氰基-5-[[3,5-二乙基-1-(2-羟基乙基)-1H-吡唑-4-基]氧基]苯腈,Lersivirine(UK 453061),UK-453061 |
HIV Protease; Reverse Transcriptase | Microbiology/Virology; Proteases/Proteasome |
Lersivirine (UK-453061) 是非核苷逆转录的抑制剂 (NNRTI),有效抑制 NNRTI 耐药病毒。它对野生型人类免疫缺陷病毒和临床相关 NNRTI 耐药菌株显示出强大的抗逆转录病毒活性。 | |||
T5981 |
2,2'-Anhydrouridine
O2,2'-Cyclouridine,2,2'-脱水尿苷,2,2'-Cyclouridine |
Antiviral; Reverse Transcriptase | Immunology/Inflammation; Microbiology/Virology |
2,2'-Anhydrouridine (2,2'-Cyclouridine) 有抗肿瘤和抗病毒活性。 | |||
T27154 |
Dexelvucitabine
D-D-4FC,DPC-817,RVT,beta-D-D-4FC,DFC |
Reverse Transcriptase | Microbiology/Virology |
Dexelvucitabine (RVT) 是一种胞苷类似物,一种口服有活性的核苷逆转录酶抑制剂。它是一种 2'-脱氧胞苷抗逆转录病毒剂。它是一种有效的抗 HIV-1病毒剂,这些病毒聚合酶中含有胸苷类似物和/或 M184V 突变。 | |||
T3632 |
Doravirine
多拉维林,多拉韦林,MK-1439 |
HIV Protease; Reverse Transcriptase | Microbiology/Virology; Proteases/Proteasome |
Doravirine (MK-1439) 是一种高度特异性的HIV-1非核苷逆转录酶抑制剂,对野生型以及K103N 和Y181C 逆转录酶突变体的IC50值分别为 4.5 nM,5.5 nM 和 6.1 nM。 | |||
T1267 |
Abacavir
Epzicom,Ziagen,阿巴卡韦,Abacavir sulfate |
Apoptosis; HIV Protease; Reverse Transcriptase | Apoptosis; Microbiology/Virology; Proteases/Proteasome |
Abacavir (Ziagen) 是一种核苷类似物逆转录酶抑制剂。 | |||
T2551 |
Etravirine
TMC125,依曲韦林,R165335 |
HIV Protease; Reverse Transcriptase | Microbiology/Virology; Proteases/Proteasome |
Etravirine (R165335) 是一种非核苷逆转录酶抑制剂,具有抗 HIV 的作用。 | |||
T2578 |
Didanosine
ddI,去羟肌苷,2',3'-Dideoxyinosine |
HIV Protease; Reverse Transcriptase | Microbiology/Virology; Proteases/Proteasome |
Didanosine (ddI) 是一种逆转录酶抑制剂,IC50为490nM。 | |||
T1649 |
Tenofovir
替诺福韦,泰诺福韦,PMPA,TDF,GS 1278 |
HBV; HIV Protease; Reverse Transcriptase | Microbiology/Virology; Proteases/Proteasome |
Tenofovir (GS 1278) 是一种核苷酸逆转录酶抑制剂,可研究 HIV 和慢性乙型肝炎。 | |||
T2409 |
Tenofovir alafenamide
替诺福韦艾拉酚胺,替诺福韦,GS-7340 |
HIV Protease; Reverse Transcriptase | Microbiology/Virology; Proteases/Proteasome |
Tenofovir alafenamide (GS-7340) 是一种核苷酸逆转录酶抑制剂和抗逆转录病毒替诺福韦的新型酯类前药。 | |||
T7111 |
Tenofovir Disoproxil
替诺福韦酯,GS 4331,Bis(POC)-PMPA |
HBV; HIV Protease; Reverse Transcriptase | Microbiology/Virology; Proteases/Proteasome |
Tenofovir Disoproxil (GS 4331) 是一种核苷酸逆转录酶抑制剂,用于治疗 HIV 和慢性乙型肝炎。 | |||
T1675 |
Adefovir dipivoxil
Hepsera,GS 0840,阿德福韦酯,Preveon |
Others; HBV; Reverse Transcriptase | Microbiology/Virology; Others |
Adefovir dipivoxil (GS 0840) 是一种腺苷类似物,是核苷逆转录酶抑制剂 Adefovir 的口服前药,具有抗乙型肝炎病毒、疱疹病毒和人类免疫缺陷病毒的活性。 | |||
T0682 |
Lamivudine
GR109714X,BCH-189,拉米夫定 |
HIV Protease; Reverse Transcriptase | Microbiology/Virology; Proteases/Proteasome |
Lamivudine (BCH-189) 是一种核苷逆转录酶抑制剂,可抑制HIV 逆转录酶1和2 以及乙型肝炎病毒的逆转录酶。 | |||
T19963 |
Alizarin Complexone
Alizarin Fluorine Blue,Alizarin-3-methyliminodiacetic acid,茜素络合指示剂 |
Reverse Transcriptase | Microbiology/Virology |
Alizarin Complexone (Alizarin-3-methyliminodiacetic acid) 是 Rous 相关病毒 2 逆转录酶的抑制剂。 Alizarin Complexone 可用作生物研究的钙示踪剂和螯合剂。 | |||
T1815 |
Dapivirine
R147681,达匹维林,TMC120 |
Apoptosis; HIV Protease; Reverse Transcriptase; Autophagy | Apoptosis; Autophagy; Microbiology/Virology; Proteases/Proteasome |
Dapivirine (R147681) 是一种二芳基嘧啶非核苷类逆转录酶抑制剂。 | |||
T1595 |
Nevirapine
NSC 641530,奈韦拉平,BI-RG 587,奈伟拉平,NVP |
HIV Protease; Reverse Transcriptase | Microbiology/Virology; Proteases/Proteasome |
Nevirapine (NVP) 是一种 HIV-1逆转录酶非核苷抑制剂,Ki 值为 270 μM,可用于研究 HIV/AIDS。 | |||
T0110 |
Zalcitabine
Dideoxycytidine,ddC,扎西他滨,NSC 606170,Ro 24-2027/000,2',3'-Dideoxycytidine |
HIV Protease; Reverse Transcriptase | Microbiology/Virology; Proteases/Proteasome |
Zalcitabine (Dideoxycytidine) 是一种核苷类似物逆转录酶抑制剂,用于HIV 感染相关研究。 | |||
T4326 |
AG 555
Tyrphostin B46,Tyrphostin AG 555 |
EGFR; Reverse Transcriptase | Angiogenesis; JAK/STAT signaling; Microbiology/Virology; Tyrosine Kinase/Adaptors |
AG 555 (Tyrphostin B46)是一种选择性EGFR 的有效抑制剂,可阻断Cdk2活化。它是一种抗逆转录病毒药。 | |||
T6367 |
Abacavir sulfate
Abacavir Hemisulfate,硫酸阿巴卡韦,1592U89,ABC sulfate,Ziagen |
Apoptosis; HIV Protease; Reverse Transcriptase | Apoptosis; Microbiology/Virology; Proteases/Proteasome |
Abacavir sulfate (Ziagen) 是一种核苷类似物逆转录酶抑制剂,可用于 HIV 和 AIDS。 | |||
T7282 |
Tenofovir alafenamide hemifumarate
GS-7340 (hemifumarate),Tenofovir alafenamide fumarate,替诺福韦艾拉酚胺富马酸盐 |
HIV Protease; Reverse Transcriptase | Microbiology/Virology; Proteases/Proteasome |
Tenofovir alafenamide hemifumarate (GS-7340 hemifumarate) 是 HIV 逆转录酶核苷酸抑制剂替诺福韦的口服膦酰胺前药。 | |||
T2393 |
Efavirenz
EFV,依非韦伦,DMP 266,依法韦仑,Sustiva,Stocrin,L-743726 |
HIV Protease; Reverse Transcriptase; Autophagy | Autophagy; Microbiology/Virology; Proteases/Proteasome |
Efavirenz (DMP 266) 是一种人类免疫缺陷病毒 1 非核苷类似物逆转录酶抑制剂。它也是一种野生型HIV-1 RT 抑制剂,Ki 为 2.93 nM,有效抑制 HIV-1 复制,IC95为 1.5 nM。 | |||
T1404 |
Stavudine
d4T,Sanilvudine,BMY-27857,NSC 163661,司他夫定 |
Apoptosis; Nucleoside Antimetabolite/Analog; HIV Protease; NOD-like Receptor (NLR); Reverse Transcriptase; Autophagy | Apoptosis; Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome |
Stavudine (BMY-27857) 是一种口服活性核苷逆转录酶抑制剂,还抑制线粒体 DNA 的复制,具有抗HIV-1和HIV-2的活性。它降低 NLRP3 炎症小体激活,调节淀粉样 β 自噬,诱导细胞凋亡。 | |||
T2409L |
Tenofovir Disoproxil Fumarate
GS-1278 Disoproxil Fumarate,Tenofovir DF,富马酸替诺福韦酯 |
HBV; HIV Protease; Reverse Transcriptase | Microbiology/Virology; Proteases/Proteasome |
Tenofovir Disoproxil Fumarate (GS-1278 Disoproxil Fumarate) 是一种核苷酸逆转录酶抑制剂,有潜力研究艾滋病和慢性乙型肝炎。 | |||
T14489 |
Azvudine
4-氨基-1-(4-C-叠氮基-2-脱氧-2-氟-BETA-D-呋喃阿拉伯糖基)-2(1H)-嘧啶酮,FNC,RO-0622 |
HCV Protease; HBV; HIV Protease; Reverse Transcriptase | Microbiology/Virology; Proteases/Proteasome |
Azvudine (FNC) 是一种有效的核苷逆转录酶抑制剂 (NRTI),对 HIV、HBV 和 HCV 具有抗病毒活性。它抑制耐 NRTI 的病毒株,高效抑制 HIV-1和 HIV-2。 | |||
T7212 |
Delavirdine mesylate
U 90152 (mesylate),BHAP-U 90152 (mesylate),Delavirdine (mesylate) |
HIV Protease; Reverse Transcriptase | Microbiology/Virology; Proteases/Proteasome |
Delavirdine mesylate (BHAP-U 90152(mesylate)) 是一种口服活性非核苷逆转录酶抑制剂。它抑制 HIV-1 病毒复制,可以用于艾滋病的相关研究。它选择性地抑制 HIV-1 逆转录酶,其选择性超过 DNA 聚合酶 α 和 DNA 聚合酶 δ 。 | |||
T2160 |
Suramin Sodium Salt
苏拉明钠,BAY-205,Suramin hexasodium salt,苏拉明钠盐,NF-060 |
Apoptosis; Phosphatase; SARS-CoV; Sirtuin; Reverse Transcriptase; Topoisomerase; Parasite | Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology |
Suramin Sodium Salt (BAY-205) 是可逆的竞争性蛋白酪氨酸磷酸酶抑制剂。它抑制 IP5K,是抗寄生虫,抗肿瘤和抗血管生成剂。它是sirtuins 的有效抑制剂,也是 SARS-CoV-2 RNA 依赖性 RNA 聚合酶抑制剂。 | |||
T9854 |
HIV-1 inhibitor-6
3-Pyridinecarboxamide, 1,4-dihydro-1-methyl-N-(5-nitro-1,2-benzisothiazol-3-yl)-4-oxo- |
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
HIV-1 inhibitor-6 (3-Pyridinecarboxamide, 1,4-dihydro-1-methyl-N-(5-nitro-1,2-benzisothiazol-3-yl)-4-oxo-) 是一种有效的HIV-1 pre-mRNA 选择性剪接抑制剂,可以阻断HIV 复制。 | |||
T21474 |
Navuridine
AZddU,CS 87,CS-87,AzUrd,3'-Azido-2',3'-dideoxyuridine,AZdU,3'-叠氮-2',3'-双脱氧尿苷 |
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Navuridine (AZdU) 是一种口服活性的 HIV 逆转录酶抑制剂,半衰期相对较短。 | |||
T12814 |
(S)-Tenofovir
(S)-替诺福韦,(S)-PMPA,(S)-GS 1278,(S)-TDF |
Others | Others |
(S)-Tenofovir ((S)-PMPA) 是Tenofovir 的活性较低的S-对映体,Tenofovir 是一种核苷酸逆转录酶抑制剂。 | |||
T7455 |
4-Chloro-2-(trifluoroacetyl)aniline hydrochloride
|
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
4-Chloro-2-(trifluoroacetyl)aniline hydrochloride 是 HIV-1 RT(HIV 逆转录酶)的抑制剂。 | |||
T1513 |
Telbivudine
NV 02B,L-Thymidine,Epavudine,替比夫定 |
Others; HBV; Reverse Transcriptase | Microbiology/Virology; Others |
Telbivudine (NV 02B) 是一种乙型肝炎病毒复制的抗病毒抑制剂,是一种具有口服活性的胸腺嘧啶核苷类似物。 | |||
T3172 |
Trovirdine
曲韦定,LY300046 |
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Trovirdine (LY300046) 是一种硫脲类非核苷类逆转录酶抑制剂。 | |||
TQ0151 | L-655708 | GABA Receptor | Membrane transporter/Ion channel; Neuroscience |
L-655708 是一种具有选择性和高效性的 GABAA 受体反向激动剂,Ki 值为 0.45 nM。 | |||
T4252 |
ML327
|
c-Myc; Autophagy | Autophagy; Cell Cycle/Checkpoint |
ML327 是 MYC 的阻断剂,还可抑制 E-钙粘蛋白转录和逆转上皮间质转化。 | |||
T31860 |
Fosdevirine
GSK-2248761A,IDX 899,GSK 2248761A,GSK 2248761,GSK-2248761,IDX-12899,GSK2248761,FDV,GSK2248761A |
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Fosdevirine (GSK2248761) 是一种具有选择性和高效性的非核苷类逆转录酶 (NNRTI) 抑制剂 ,具有抗 HIV 活性,可用于研究迟发性癫痫等神经系统相关疾病。 | |||
T15210 |
Elsulfavirine
Elpida,VM-1500 |
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Elsulfavirine (VM-1500) 是一种 HIV-1 感染的逆转录酶抑制剂,也是抗 HIV 的新药。 | |||
T27260 |
Emivirine
MKC442,MKC-442,MKC 442,DRG-0302,DRG 0302,DRG0302 |
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Emivirine (MKC-442) 是一种有效和选择性的人类免疫缺陷病毒1型(HIV-1)的非核苷逆转录酶抑制剂。 | |||
T68103 |
MK-6186
|
Reverse Transcriptase | Microbiology/Virology |
MK-6186 是一种新型非核苷类逆转录酶抑制剂,具有抗病毒活性,可用于研究病毒感染。 | |||
T6287 |
Tariquidar
XR9576,他立喹达 |
P-gp | Membrane transporter/Ion channel; Neuroscience |
Tariquidar (XR9576) 是一种特异性有效的P-糖蛋白抑制剂,Kd 为 5.1 nM。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3795 |
Corilagin
|
Apoptosis; TLR; Reverse Transcriptase; Antibacterial; Autophagy | Apoptosis; Autophagy; Immunology/Inflammation; Microbiology/Virology |
Corilagin 是一种鞣酸,有抑制 RNA 肿瘤病毒逆转录酶的活性。它抑制金黄色葡萄球菌的生长,MIC 为 25 μg/mL。它有抗肿瘤活性,可用于肝癌和卵巢癌。 | |||
T6519 |
Gramine
NSC 16892,芦竹碱,Donaxine |
Adiponectin receptor; Reverse Transcriptase; Adrenergic Receptor | GPCR/G Protein; Microbiology/Virology; Neuroscience |
Gramine (Donaxine) 是从芦竹中得到的一种生物碱,是脂联素受体激动剂,对 AdipoR2 和 AdipoR1 的 IC50值分别为 3.2 和 4.2 µM。它也是小鼠和人β2-肾上腺素受体激动剂,具有抗肿瘤、抗炎和抗病毒作用。 | |||
T2901 |
Daidzin
NPI-031D,大豆苷,Daidzein 7-O-glucoside,Daidzoside,黄豆苷,Daidzein 7-glucoside |
Dehydrogenase; Reverse Transcriptase; Mitochondrial Metabolism | Metabolism; Microbiology/Virology |
Daidzin (Daidzoside) 是从大豆中分离出来的一种异黄酮,具有抗氧化、抗癌和抗动脉粥样硬化的活性。 | |||
T3578 |
Pyridoxal phosphate
PLP,PAL-P,磷酸吡哆醛,pyridoxal 5'-phosphate,Pyridoxyl phosphate,Pyridoxal 5′-phosphate,Vitamin B6 phosphate |
Reverse Transcriptase; Endogenous Metabolite | Metabolism; Microbiology/Virology |
Pyridoxal phosphate (Vitamin B6 phosphate) 是维生素 B6 的活性形式,可抑制逆转录酶活性,用于研究迟发性运动障碍症。 | |||
T6S0923 |
Hypericin
Hypericine,金丝桃素,Cyclosan |
Apoptosis; Antiviral; Influenza Virus; Tyrosine Kinases; Antibacterial; PKC | Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; Immunology/Inflammation; Microbiology/Virology; Tyrosine Kinase/Adaptors |
Hypericin (Cyclosan) 是贯叶连翘的提取物,有抗菌、抗病毒、抗肿瘤和抗抑郁作用。 | |||
TN1427 |
Baicalin methyl ester
|
Anti-infection | Microbiology/Virology |
Baicalin methyl ester 是黄芩苷根的一种成分。 | |||
T4972 |
2'-Deoxycytidine-5'-diphosphate trisodium
dCDP,2'-脱氧胞苷-5'-二磷酸三钠盐 |
Endogenous Metabolite | Metabolism |
2'-Deoxycytidine-5'-diphosphate trisodium (dCDP) 是内源性代谢产物的一种。 | |||
T3730 |
Methyl gallate
NSC 363001,Gallicin,Gallic acid methyl ester,Gallincin,没食子酸甲酯 |
Reactive Oxygen Species; HIV Protease; Reverse Transcriptase; Antibacterial | Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB; Proteases/Proteasome |
Methyl gallate (Gallincin) 是具有抗氧化,抗癌和抗炎活性的植物酚类。它也可抑制细菌活性。它还具有抗HIV-1和HIV-1酶的抑制活性。 | |||
T4S1718 |
Punicalin
|
HBV; HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Punicalin 是从Punica granatumL. 或Terminalia catappaL. 的叶子中分离的,一种可水解的单宁,具有抗炎活性。它是一种抗乙型肝炎病毒药物。 | |||
T9086 |
Deoxythymidine-5'-triphosphate trisodium
dTTP trisodium salt,thymidine 5'-(trisodium hydrogen triphosphate),胸苷-5'-三磷酸三钠盐,脱氧胸苷三磷酸三钠盐,Deoxythymidine-5'-triphosphate (dTTP) trisodium salt |
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
Deoxythymidine-5'-triphosphate trisodium (Deoxythymidine-5'-triphosphate(dTTP) trisodium salt) 是四种天然脱氧核苷酸之一,用于通过 DNA 聚合酶和逆转录酶生物合成脱氧核糖核酸。 | |||
T3S0335 |
Soyasaponin Bb
Soyasaponin I,大豆皂苷Bb |
NF-κB; Caspase | Apoptosis; NF-κB; Proteases/Proteasome |
Soyasaponin Bb (Soyasaponin I) 是一种分离自菜豆科中的大豆皂苷,可用作醛糖还原酶差异抑制剂。 | |||
T6S1842 |
Tenacissoside G
Tenacissimoside A,通关藤苷G |
Others | Others |
Tenacissoside G 是一种 C21 甾体,来自于Marsdenia tenacissima 茎部。它可逆转 P-糖蛋白过度表达的多药耐药癌细胞的多药耐药。 | |||
T2S0265 |
Robinin
NSC 9222,刺槐素 |
TLR | Immunology/Inflammation |
Flavone glycoside from Robinia with antibacterial and diuretic properties; derived from kaempferol.The ability of robinin to reverse the multidrug resistance of the human colon cancer cell line Colo 320 expreβing MDR1/LRP was explored by monitoring their uptake of Rhodamine 123, but was shown to have minimal effect. Robinin (NSC-9222) was detected in lysates of the human breast cancer cell line MCF-7 using liquid chromatography-tandem maβ spectrometry. | |||
T4A2399 |
Cinobufotalin
华蟾毒它灵,华蟾素 |
IL Receptor; Akt; MRP; P-gp | Cytoskeletal Signaling; Immunology/Inflammation; Membrane transporter/Ion channel; Neuroscience; PI3K/Akt/mTOR signaling |
Cinobufotalin 是一种从蟾蜍的皮肤分泌物中提取的强心类固醇或丁二烯内酯。它已被用作强心药,利尿药和止血药,也是潜在的抗肺癌药物。 | |||
TN1163 |
2'-Hydroxychalcone
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Others | Others |
2'-Hydroxychalcone 是一种药物合成中间体,可用于合成黄酮类化合物。负载在纳米乳液中的2'-Hydroxychalcone 在Danio rerio 模型对副球孢子菌显示出杀真菌活性。2'-Hydroxychalcone 通过负载脂质的Hepg2细胞中的氧化应激诱导细胞毒性。2'-Hydroxychalcone 抑制通过逆转录聚合酶链反应确定的肿瘤坏死因子-α诱导ICAM-1,VCAM-1和E-选择素的稳态转录水平,因此可能会干扰其基因的转录。 | |||
T37984 |
D-Fructose-1,6-bisphosphate sodium salt hydrate
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Others | Others |
D-Fructose-1,6-bisphosphate sodium salt hydrate 是碳水化合物代谢的中间体,包括糖酵解和糖异生。在糖酵解过程中,它是由磷酸果糖激酶磷酸化果糖-6-磷酸产生的。由果糖-1,6-二磷酸酶-1介导的逆反应是糖异生的限速步骤之一。同样的反应也发生在植物的叶绿体中,D-Fructose-1,6-bisphosphate sodium salt hydrate 作为还原性戊糖磷酸循环的一部分。由于癌细胞采用糖酵解作为代谢能量产生的主要来源,这一途径已成为癌症化疗的主要靶点。 | |||
T4838 |
(S)-Malic acid
L-(-)-Malic acid,(S)-(-)-HYDROXYSUCCINIC ACID,(S)-2-Hydroxysuccinic acid,L-苹果酸 |
Others; Endogenous Metabolite | Metabolism; Others |
(S)-Malic acid ((S)-2-Hydroxysuccinic acid) 是天然存在的二羧酸,是水果酸甜味的来源,常用作食品添加剂。 | |||
T2S0605 | Liquidambaric lactone | HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Liquidambaric lactone 是一种分离自Euonymus grandiflorusWall 中的化合物。 | |||
T13796 | Nigranoic acid | HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Nigranoic acid is a natural product,and inhibits HIV-1 reverse transcriptase. | |||
TN4934 |
Salaspermic acid
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HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Salaspermic acid is an inhibitor of HIV reverse transcriptase and HIV replication in H9 lymphocyte cells. | |||
TN5243 |
Vitexilactone
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NADPH-oxidase; HIV Protease; Antifection | Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome |
Vitexilactone is a HIV-1 reverse transcriptase inhibitor in virtual screening against Indonesian Herbal Database using AutoDock4 performed on HIV-1 reverse transcriptase. It has trypanocidal activity, the minimum lethal concentration against epimastigotes | |||
T74196 | Inophyllum B | ||
Inophyllum B ((+)-Inophyllum B) 是一种有效的HIV 逆转录酶 (Reverse Transcriptase) 抑制剂,IC50为 38 nM。Inophyllum B 在体外细胞培养中抑制HIV-1(IC50=1.4 μM)。Inophyllum B 可从非洲大蜗牛Achatina fulica 的丙酮提取物中分离得到。 | |||
T2S0118 | Daurinoline | Calcium Channel; 5-HT Receptor; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience |
Daurinoline is a non-competitive antagonist, it exerts marked relaxation effect on basilar artery of rabbits through non-competitive antagonism, it would have a protective function on microcirculation of cerebral pia mater, which may be beneficial to relieve cerebral ischemic injury. Daurinoline could significantly reverse noradrenaline induced constriction of pial arterioles and venules, and increase the number of blood vessels which were decreased by noradrenaline. | |||
TN6198 |
Mahanine
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Mahanine has effects on the activation of the apoptotic pathway in human leukemia U937 cells, causes the mitochondrial membranes to lose their permeability, resulting in caspase-3 activation and apoptosis. Mahanine can reverse an epigenetically silenced g | |||
TN5133 | 3',5,5',7-Tetrahydroxy-4',6-dimethoxyflavone | HIV Protease; Topoisomerase | DNA Damage/DNA Repair; Microbiology/Virology; Proteases/Proteasome |
5,7,3',5'-tetrahydroxy-6,4'-dimethoxyflavone exhibits anti-HIV-1 activity in the anti-syncytium assay using (∆Tat/rev)MC99 virus and 1A2 cell line system, it shows considerably activity against HIV-1 reverse transcriptase. It exhibits cytotoxic activity against P-388 cell lines, it can inhibit DNA topoisomerase IIα activity, which may be responsible for the observed cytotoxicity. |