Powder: -20°C for 3 years | In solvent: -80°C for 1 year
R-10015 是一种高效选择性 LIMK 抑制剂,通过结合 ATP 结合口袋阻断 LIMK,抑制人 LIMK1 的 IC50值为 38 nM。它还发挥广谱抗病毒作用,可用于 HIV 感染研究。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 813 | 现货 | ||
2 mg | ¥ 1,190 | 现货 | ||
5 mg | ¥ 1,990 | 现货 | ||
10 mg | ¥ 3,160 | 现货 | ||
25 mg | ¥ 5,990 | 现货 | ||
50 mg | ¥ 8,520 | 现货 | ||
100 mg | ¥ 11,300 | 现货 | ||
500 mg | ¥ 22,800 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 2,190 | 现货 |
产品描述 | R-10015 is a highly potent and selective LIMK inhibitor that blocks LIMK by binding to the ATP-binding pocket. It inhibits human LIMK1 with an IC50 value of 38 nM. It also exerts broad-spectrum antiviral effects and may be used in HIV infection research. |
靶点活性 | LIMK1 (human):38 nM |
体外活性 | R10015 as a lead compound that blocks LIMK activity by binding to the ATP-binding pocket.?R10015 specifically blocks viral DNA synthesis, nuclear migration, and virion release.?In addition, R10015 inhibits multiple viruses, including Zaire ebolavirus (EBOV), Rift Valley fever virus (RVFV), Venezuelan equine encephalitis virus (VEEV), and herpes simplex virus 1 (HSV-1), suggesting that LIMK inhibitors could be developed as a new class of broad-spectrum antiviral drugs. |
分子量 | 410.86 |
分子式 | C20H19ClN6O2 |
CAS No. | 2097938-51-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 62.5 mg/mL (152.12 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.4339 mL | 12.1696 mL | 24.3392 mL | 60.848 mL |
5 mM | 0.4868 mL | 2.4339 mL | 4.8678 mL | 12.1696 mL | |
10 mM | 0.2434 mL | 1.217 mL | 2.4339 mL | 6.0848 mL | |
20 mM | 0.1217 mL | 0.6085 mL | 1.217 mL | 3.0424 mL | |
50 mM | 0.0487 mL | 0.2434 mL | 0.4868 mL | 1.217 mL | |
100 mM | 0.0243 mL | 0.1217 mL | 0.2434 mL | 0.6085 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
R-10015 2097938-51-5 Cell Cycle/Checkpoint Microbiology/Virology LIM Kinase Reverse Transcriptase inhibit Inhibitor LIMKs R 10015 LIM Kinase (LIMK) R10015 inhibitor