42
14
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T16550 |
PKR-IN-C16
|
Others | Others |
PKR-IN-C16 是一种特异性蛋白激酶抑制剂。它能够抑制 PKR 的自磷酸化,解除 PKR 在原代神经元细胞培养中诱导的翻译阻断。 | |||
T0267 |
Zonisamide
AD 810,唑尼沙胺,CI 912 |
Calcium Channel; Sodium Channel; Carbonic Anhydrase | Membrane transporter/Ion channel; Metabolism |
Zonisamide (AD 810) 是锌酶碳酸酐酶 (carbonic anhydrase) 的有效抑制剂,对人类线粒体同工酶 hCA II 和 hCA V 作用的 Ki 值分别为 35.2 nM 和 20.6 nM。Zonisamide 具有抗癫痫活性,在癫痫、癫痫发作和帕金森病的研究中具有价值。 | |||
T9079 |
Apostatin-1
Apt-1 |
Others | Others |
Apostatin-1 (Apt-1) 是一种新型 TRADD 抑制剂。 Apostatin-1 可以与 TRADD 的 N 末端 TRAF2 结合域上的口袋结合。 | |||
T16079 |
Mirodenafil
米罗那非,SK3530 |
PDE | Metabolism |
Mirodenafil 是一种磷酸二酯酶5(PDE-5)抑制剂,可用于勃起功能紊乱的研究。 | |||
T2264 |
AM281
1-(2,4-二氯苯基)-5-(4-碘苯基)-4-甲基-N-4-吗啉基-1H-吡唑-3-甲酰胺 |
Cannabinoid Receptor | GPCR/G Protein |
AM281 是选择性CB1受体拮抗剂,IC50=9.91 nM。它抑制 CB2 受体,IC50=13000 nM。 | |||
T1567 |
Olanzapine
LY170053,奥氮平 |
Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor; AChR | GPCR/G Protein; Neuroscience |
Olanzapine (LY170053) 是一种非典型抗精神病药,目前用于治疗精神分裂症和双相情感障碍。 | |||
TQ0126 |
Mirodenafil dihydrochloride
SK-3530 dihydrochloride,米罗那非二盐酸盐 |
PDE | Metabolism |
Mirodenafil dihydrochloride 是一种磷酸二酯酶5(PDE-5)抑制剂,可作用于勃起功能紊乱的研究。 | |||
T1637 |
Deferoxamine Mesylate
desferrioxamine B,Desferrioxamine B mesylate,DFO,DFOM,去铁铵,甲磺酸去铁胺 |
Mitophagy; Beta Amyloid; Others; Ferroptosis; HIF/HIF Prolyl-Hydroxylase; Autophagy | Apoptosis; Autophagy; Chromatin/Epigenetic; Metabolism; Neuroscience; Others |
Deferoxamine Mesylate (DFOM) 是一种铁螯合剂和铁死亡抑制剂。Deferoxamine Mesylate 可将游离铁结合成稳定的复合物,减少铁的积累。Deferoxamine Mesylate 可以上调 HIF-1α 水平,诱导细胞凋亡。 | |||
T12352 |
Oxidopamine hydrochloride
6-Hydroxydopamine hydrochloride,6-OHDA hydrochloride,6-羟基多巴胺盐酸盐 |
Mitophagy; Dopamine Receptor; Autophagy | Autophagy; GPCR/G Protein; Neuroscience |
Oxidopamine hydrochloride (6-Hydroxydopamine hydrochloride) 是一种神经递质多巴胺拮抗剂,可选择性地破坏多巴胺能神经元,是一种广泛使用的神经毒素。 | |||
T12352L |
Oxidopamine hydrobromide
6-Hydroxydopamine hydrobromide,6-羟基多巴胺氢溴酸盐,6-OHDA hydrobromide |
Mitophagy; Dopamine Receptor; Autophagy | Autophagy; GPCR/G Protein; Neuroscience |
Oxidopamine hydrobromide (6-OHDA hydrobromide) 是一种神经递质多巴胺拮抗剂,可选择性地破坏多巴胺能神经元,是一种广泛使用的神经毒素。 | |||
T39195 |
YM-244769 dihydrochloride
|
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
YM-244769 dihydrochloride 是一种有效的 Na+/Ca2+ exchange 3 (NCX3) 抑制剂,IC50 为 18 nM。 YM-244769 dihydrochloride 对神经元和肾脏具有有效的保护作用。 | |||
T9888 |
YM-244769
3-Pyridinecarboxamide, N-[(3-aminophenyl)methyl]-6-[4-[(3-fluorophenyl)methoxy]phenoxy]- |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
YM-244769 (3-Pyridinecarboxamide, N-[(3-aminophenyl)methyl]-6-[4-[(3-fluorophenyl)methoxy]phenoxy]-) 是一种有效的 Na+/Ca2+ exchange 3 (NCX3) 抑制剂,IC50 为 18 nM。 YM-244769 对神经元和肾脏具有有效的保护作用。 | |||
T40063 |
CBR-470-1
|
Nrf2 | Immunology/Inflammation |
CBR-470-1 是一种有效的糖酵解磷酸甘油酸激酶1 (PGK1) 抑制剂,通过增加甲基乙二醛的水平来激活 NRF2。 CBR-470-1 是一种非共价的 Nrf2 激活剂,具有神经保护活性,通过激活 Keap1-Nrf2 级联反应来保护 SH-SY5Y 神经元细胞免受 MPP+ 诱导的细胞毒性。 | |||
T2625 |
MK-0752
|
Beta Amyloid; Gamma-secretase | Neuroscience; Proteases/Proteasome; Stem Cells |
MK0752 是一种高效的、特异性的、可穿过血脑屏障的、口服活性的 γ-分泌酶(γ-secretase)抑制剂,对人 SH-SY5Y 细胞 Aβ40 呈剂量依赖性降低(IC50=5 nM)。它能够降低体内新生的中枢神经系统 Aβ。 | |||
T61268 |
Vutiglabridin
HSG4112 |
Phosphatase | Metabolism |
Vutiglabridin (HSG4112) 是一种新型且安全的PON2调节剂,是一个外消旋化合物。Vutiglabridin 是Glabridin 的优化结构类似物,比Glabridin 在减重效果和化学稳定性方面更加优越。Vutiglabridin 通过靶向线粒体对氧磷酶-2改善mptp 诱导的帕金森病小鼠的神经变性。Vutiglabridin 是一种治疗肥胖的临床2期药物,在PD 模型中对对线粒体PON2具有治疗作用。Vutiglabridin 渗透到大脑,结合PON2,恢复1-甲基-4-苯基吡啶(MPP*)诱导的SH-SY5Y 神经母细胞瘤细胞线粒体功能障碍。Vutiglabridin 在小鼠实验中 显著减轻了1-甲基-4苯基-1,2,3,6-四氢吡啶(MPTP)诱导的PD 模型小鼠的运动障碍和多巴胺能神经元损伤。 | |||
T9169 |
MPP+ iodide
|
Mitochondrial Metabolism; Autophagy | Autophagy; Metabolism |
MPP+ iodide 是一种 5-羟色胺转运体的高亲和力底物,也是一种神经毒素 MPTP 的有毒代谢物,通过选择性破坏黑质多巴胺能神经元,在动物模型中引起帕金森病症状。它被多巴胺转运体吸收进入多巴胺能神经元,通过影响呼吸链复合体 I 对线粒体发挥神经毒性作用。 | |||
T35689 |
MTP 131 acetate
|
Others | Others |
MTP 131 acetate 是一种小的线粒体靶向四肽。 | |||
T80520 |
ω-conotoxin MoVIA
|
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
ω-conotoxin MoVIA为选择性Cav2.2抑制剂,SH-SY5Y细胞荧光测定法中hCav2.2的IC50值为0.33 μM。 | |||
T60792 | NMDA receptor antagonist-3 | ||
NMDA receptor antagonist-3 是NMDA 受体的拮抗剂。NMDA receptor antagonist-3 在 SH-SY5Y 和人脂肪间充质干细胞中具有显著的回收率(40.0 %,100 μM)和安全的毒理学特性。 | |||
T26705 |
AZ-4217
AZ4217,AZ 4217 |
||
AZ-4217 is a high potency BACE inhibitor. It displays acute central efficacy in different in vivo models and reduced amyloid deposition in Tg2576 mice. AZ-4217 has IC50 160 pM in human SH-SY5Y cells with an excellent in vivo efficacy. | |||
T26821 | BIPM | ||
BIPM is a potent inhibitor of Rho-associated protein kinase 2 (ROCK2). Exposure of SH-SY5Y cells to BIPM led to significant changes in cell migration, actin stress fibers and neurite length. BIPM significantly inhibits phosphorylation of cofilin, a regula | |||
T15412 |
GPP78
CAY10618 |
Autophagy | Autophagy |
GPP78 is a potent inhibitor of Nampt (IC50: 3.0 nM for nicotinamide adenine dinucleotide (NAD) depletion). GPP78 is cytotoxic to neuroblastoma cell line SH-SY5Y cells (IC50: 3.8 nM by inducing autophagy). GPP78 has anti-cancer and anti-inflammatory effect | |||
T71026 | MC2050 HCl | ||
MC2050 is a potent PARP-1 inhibitor. The IC50 for inhibition of PARP-1 activity is 119 nM, compared to 1.8 μM for PARP-2. MC2050 inhibits apoptosis and blocks poly ADP-ribosylation of histone H1 in hydrogen peroxide treated SH-SY5Y neuroblastoma cells. | |||
T28160 |
Nerispirdine HCl
HP-184,HP 184,Nerispirdine hydrochloride,HP184 |
||
Nerispirdine is a acetylcholine release enhancer, sodium channel blocker and K(V) 2.1 channel blocker. Nerispirdine inhibits voltage-dependent Na(+) channel currents recorded from human SH-SY5Y cells with an IC(50) of 11.9 micromol/L when measured from a | |||
T63628 | AChE-IN-19 | ||
AChE-IN-19 是 AChE 的高效抑制剂 (IC50: 0.56 μM),对 Aβ 聚集也表现出抑制作用。AChE-IN-19 表现出神经保护作用,对 SH-SY5Y 细胞几乎没有毒性。AChE-IN-19 能够用于研究阿尔兹海默症。 | |||
T60528 | PDPOB | ||
PDPOB 是一种苯基羧酸衍生物,具有用于脑缺血研究的潜力。PDPOB 被证明可以防止 SH-SY5Y 细胞中 OGD/R 诱发的多方面神经元退化,减轻的线粒体功能障碍、氧化应激和细胞凋亡证明了这一点。 | |||
T37578 |
GPP 78 hydrochloride
|
||
GPP 78 hydrochloride 是一种有效的烟酰胺磷酸核糖转移酶 (Nampt) 抑制剂,对 NAD 消耗的 IC50 为 3 nM。GPP 78 hydrochloride 通过诱导自噬对神经母细胞瘤细胞 SH-SY5Y 具有毒性,IC50 为 3.8 nM。GPP78 具有抗癌和抗炎作用。 | |||
T60678 |
hMAO-B-IN-2
|
||
hMAO-B-IN-2 (compound 6j) 是具有口服活性、选择性的、且竞争性可逆的 hMAO-B 抑制剂 (IC 50 = 4 nM),可穿透血脑屏障。hMAO-B-IN-2 对 SH-SY5Y 细胞显示出良好的神经保护作用和低毒性,可用于阿尔茨海默症的研究。 | |||
T36427 |
PACAP (6-27) (human, chicken, mouse, ovine, porcine, rat) (trifluoroacetate salt)
|
PACAP | GPCR/G Protein |
Pituitary adenylate cyclase-activating peptide (PACAP) (6-27) is a PACAP receptor antagonist with IC50 values of 1,500, 600, and 300 nM, respectively, for rat PAC1, rat VPAC1, and human VPAC2 recombinant receptors expressed in CHO cells. It binds to PACAP receptors on SH-SY5Y and SK-N-MC human neuroblastoma and T47D human breast cancer cells (IC50s = 24.5, 106, and 105 nM, respectively) and inhibits cAMP accumulation induced by PACAP (1-38) (Kis = 457, 102, and 283 nM, respectively, in SH-SY5Y, ... | |||
T60748 |
ZDWX-25
|
||
ZDWX-25 是 GSK-3β和 DYRK1A 的高效双重抑制剂,它对 SH-SY5Y 和 HL-7702 细胞显示出显著的细胞毒性。ZDWX-25 可用于研究阿尔茨海默症,其对 GSK-3β 的 IC50值为 71 nM。。 | |||
T80516 |
human GALP (3-32)
Galanin-like peptide (3-32) |
Neuropeptide Y Receptor | GPCR/G Protein; Neuroscience |
Human GALP (3-32) (Galanin-like peptide (3-32)) 是一种高效的galanin receptor激动剂。在竞争性结合实验中,该化合物对GalR1 (IC50=33 nM) 及GalR2 (IC50=15 nM) 表现出强烈亲和力。此外,human GALP (3-32) 显著增加了转染GalR2 (EC50=360 nM) 的 SH-SY5Y细胞的胞外酸化速率。 | |||
T63873 | Anti-Aβ agent 1A | ||
Anti-Aβ agent 1A 是有效的抗淀粉样蛋白-β (amyloid-β) 剂。Anti-Aβ agent 1A 可明显抑制 LPS 诱导的 IL-1β、IL-6 和 TNF-α 水平,并能够利用线粒体途径减少 H2O2诱导的 SH-SY5Y 细胞凋亡,表现出抗氧化、抗炎、抗 Aβ 毒性和神经保护活性。Anti-Aβ agent 1A 能够用于研究阿尔兹海默症。 | |||
T35745 |
Marcfortine A
|
||
Marcfortine A is an indole alkaloid originally isolated from P. roqueforti. It has nematocidal activity against the parasitic nematode H. contortus (LD99 = 0.06 μg/ml) and inhibits motility of adult worms (EC50 = 2 μM)., Marcfortine A eliminates H. contortus, T. colubriformis, and O. ostertagi from experimentally infected jirds (ED95s = 0.33, 0.11, and 2.5 mg/animal, respectively). It dose-dependently inhibits nicotine-induced calcium mobilization in SH-SY5Y and TE-671 cells expressing α3 subuni... | |||
T68547 | SNJ-1945 | ||
SNJ-1945 is a calpain inhibitor with more favorable retinal penetration, high oral bioavailability, and long half-life. SNJ1945 rescued defective function in lissencephaly. SNJ-1945 protects SH-SY5Y cells against MPP(+) and rotenone. SNJ-1945 reduces murine retinal cell death in vitro and in vivo. SNJ-1945 has good aqueous solubility, can prevents the heart from KCl arrest-reperfusion injury associated with the impairment of total Ca(2+) handling by inhibiting the proteolysis of alpha-fodrin a... | |||
T81867 | MAO-B-IN-26 | Autophagy | Autophagy |
MAO-B-IN-26(Compound IC9)是一种双重功能抑制剂,针对MAO-B和乙酰胆碱酯酶进行抑制。它能有效地防护SH-SY5Y细胞,对抗由Aβ引起的细胞毒性、形态学变化、反应性氧(ROS)产生和膜损伤。此外,MAO-B-IN-26还可抑制Aβ触发的自噬(autophagy)和细胞凋亡(apoptosis),具备作为治疗阿尔茨海默病的神经保护剂的潜力。 | |||
T73658 |
Orexin A (human, rat, mouse) (acetate)
|
||
Orexin A (Hypocretin-1) (human, rat, mouse) acetate 是一种具有镇痛特性的下丘脑神经肽 (可透过血脑屏障)。Orexin A (human, rat, mouse) acetate 也是一种OX1R 激动剂,能以时间和剂量依赖性的方式诱导 SH-SY5Y 细胞BDNF 和TH 蛋白的表达。Orexin A (human, rat, mouse) acetate 可用于食欲调节、神经退行性疾病,以及调节伤害性信息传递的研究。 | |||
T35811 |
CAY10410
|
||
CAY10410 is an analog of prostaglandin D2/prostaglandin J2 (PGD2/PGJ2) with structural modifications intended to give it PPARγ ligand activity and resistance to metabolism. 15-deoxy-δ12,14-PGJ2 has been shown to be a potent ligand for PPARγ. Metabolism of the cyclopentenone prostaglandins PGA2, PGJ2, and δ12-PGJ2 occurs via glutathione addition across the α,β unsaturated enone. CAY10410 was designed as an analog of the PPARγ-binding prostaglandins which could not undergo this conjugation reactio... | |||
T83875 |
HUP-55
|
||
HUP-55是一种脯氨酸内肽酶的抑制剂(IC50 = 5 nM)。在10 µM的浓度下,它可减少Neuro2a细胞中α-突触核蛋白二聚体的形成,促使HEK293细胞发生自噬,并降低SH-SY5Y细胞中由过氧化氢诱导的反应性氧种(ROS)产量的增加。此外,HUP-55(10 mg/kg)在通过腺病毒递送α-突触核蛋白编码载体(AAV-αSyn)诱导的帕金森病小鼠模型中,能减少患侧爪的使用和纹状体中寡聚体α-突触核蛋白水平。 | |||
T36554 |
TMB 8 (hydrochloride)
|
||
TMB 8 is a non-competitive antagonist of nicotinic acetylcholine receptors (nAChRs) with IC50 values of 390 and 350 nM, respectively, for human muscle-type and α3β4 subunit-containing ganglionic nAChRs expressed in TE671/RD or SH-SY5Y cells. It inhibits nicotine-induced dopamine release from rat brain synaptosomes (IC50 = 480 nM). TMB 8 also reduces calcium availability in smooth and skeletal muscle, blocking the contractile response in isolated rabbit aortic strip when used at a concentration o... | |||
T64137 |
AChE/BuChE-IN-3
|
||
AChE/BuChE-IN-3 是一种有效的、能够透过血脑屏障的 AChE (IC50: 0.65 μM) 与 BuChE (IC50: 5.77 μM) 抑制剂,对 Aβ1-42 的聚集也表现出抑制作用。AChE/BuChE-IN-3 表现出有效的神经保护活性,对 SH-SY5Y 细胞几乎没有毒性。AChE/BuChE-IN-3 能够用于研究阿尔兹海默症。 | |||
T37114 |
SB 242084 dihydrochloride
|
||
SB 242084 hydrochloride is a 5-HT2C receptor antagonist(pKi=9.0) that displays 158- and 100-fold selectivity over 5-HT2A and 5-HT2B receptors respectively.IC50 value: 9.0(pKi) [1]Target: 5-HT2C antagonistin vitro: SB 242084 had over 100-fold selectivity over a range of other 5-HT, dopamine and adrenergic receptors. In studies of 5-HT-stimulated phosphatidylinositol hydrolysis using SH-SY5Y cells stably expressing the cloned human 5-HT2C receptor, SB 242084 acted as an antagonist with a pKb of 9.... | |||
T37202 |
CC4
CC4 |
||
High affinity and subtype selective α6β2 and α4β2 partial agonist (Ki values are 12 and 26nM for rat α6β2 and α4β2 receptors respectively). Has low affinity for α3β4 and α7 receptors (Ki values are 4.8 and 13 μM for human α3β4 and rat α7 receptors respectively). Stimulates dopamine release from striatal slices in vitro. Attenuates nicotine-induced self-administration and conditional place preference in rats. Sala et al (2013) CC4, a dimer of cytisine, is a selective partial agonist at α4β2/α6β2 ... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T2808 |
Bilobalide
白果内酯,银杏内酯,(-)-Bilobalide |
Apoptosis; Endogenous Metabolite; Autophagy | Apoptosis; Autophagy; Metabolism |
Bilobalide ((-)-Bilobalide) 是银杏叶中的的一种倍半萜三内酯成分,抑制 NMDA 诱导的胆碱流出,IC50值为 2.3 µM。它通过激活 SH-SY5Y 细胞中的 PI3K/Akt 通路来防止细胞凋亡。对神经元发挥保护和营养作用。 | |||
T7983 |
Isoborneol
DL-Isoborneol,异冰片,异龙脑 |
HSV | Microbiology/Virology |
Isoborneol (DL-Isoborneol) 是存在于许多药用植物精油中的一种单萜醇,具有抗氧化和抗病毒特性,是 1 型单纯疱疹病毒(HSV-1)的有效抑制剂。 | |||
T7090 |
Jionoside A1
焦地黄苯乙醇甙A1,焦地黄苯乙醇苷A1 |
Others | Others |
Jionoside A1 分离自Radix Rehmanniae Praeparata 中,具有剂量依赖性免疫增强作用,并对 H2O2处理的 SH-SY5Y 细胞具有中等保护活性。 | |||
T27012 |
Chrysotoxine
Phenol, 4-[2-(3,4-dimethoxyphenyl)ethyl]-2,6-dimethoxy-,4-[2-(3,4-Dimethoxyphenyl)ethyl]-2,6-dimethoxyphenol,鼓槌石斛素 |
NF-κB | NF-κB |
Chrysotoxine (Phenol, 4-[2-(3,4-dimethoxyphenyl)ethyl]-2,6-dimethoxy-) 通过 NF-κB 调节和线粒体保护抑制 SH-SY5Y 细胞中 6-羟基多巴胺诱导的细胞凋亡。 | |||
T8852 |
tubuloside B
|
Apoptosis; Others | Apoptosis; Others |
Tubuloside B 是可从管花肉苁蓉茎中分离出的一种天然产物,具有抗氧化活性,可抑制TNFα 诱导的细胞凋亡。 | |||
TN1891 |
Lupiwighteone
|
Apoptosis; BCL; PARP; Caspase | Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Proteases/Proteasome |
Lupiwighteone 是一种广泛存在于野生植物中的异黄酮。它通过抑制 PI3K/Akt/mTOR 通路,诱导人乳腺癌细胞 caspase 依赖性和非依赖性凋亡,具有抗氧化、抗菌和抗癌作用。 | |||
T3803 |
Specnuezhenide
特女贞苷,Nuzhenide,Nuezhenide |
Others; NF-κB; Wnt/beta-catenin | Cytoskeletal Signaling; NF-κB; Others; Stem Cells |
Specnuezhenide (Nuezhenide) 是分离自女贞子的果实中。它可抑制 NF-κB 和 wnt/β-catenin 信号传导,进而抑制 IL-1β 诱导的软骨细胞炎症。它可在骨关节炎 (OA) 大鼠模型中发挥抗炎作用。 | |||
TN4368 |
Kaempferol-3,7-di-O-β-glucoside
Kaempferol 3,7-di-O-glucoside |
Glucosidase; Amylase | Metabolism |
Kaempferol-3,7-di-O-β-glucoside (Kaempferol 3,7-diglucoside) 是一种来自 Morettia philaena 的黄酮醇,对 α-淀粉酶 (α-amylase)、α-葡萄糖苷酶 (α-glucosidase) 和乙酰胆碱酯酶 (Acetylcholinesterase) 具有抑制作用。Kaempferol-3,7-di-O-β-glucoside 具有神经保护活性,可减缓分化神经元细胞 SH-SY5Y 免受 Amyloid β 肽诱导的损伤。Kaempferol-3,7-di-O-β-glucoside 可用于研究阿尔茨海默氏症类的神经系统疾病。 | |||
TL0005 |
3,5-O-Dicaffeoylquinic acid
Isochlorogenic Acid A,(-)-3,5-二咖啡酰奎宁酸,(-)-3,5-Dicaffeoyl quinic acid,3,5-Dicaffeoylquinic Acid |
Others | Others |
3,5-O-Dicaffeoylquinic acid (Isochlorogenic Acid A) 能够改善由三甲基锡诱导的学习和记忆缺陷。 | |||
T5S1805 |
5,7-Dihydroxychromone
5,7-Dihydroxy-4H-Chromen-4-One,5,7-二羟基色酮,5,7-二羟基色原酮 |
Others; Virus Protease; PARP; Caspase; Nrf2 | Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Immunology/Inflammation; Microbiology/Virology; Others; Proteases/Proteasome |
5,7-Dihydroxychromone (5,7-Dihydroxy-4H-Chromen-4-One) 是一种Cudrania tricuspidata 的提取物,通过激活 Nrf2/ARE 信号对 6-OHDA 诱导的氧化应激和细胞凋亡发挥神经保护作用。它抑制 6-OHDA 诱导的 SH-SY5Y 细胞中活化的caspase-3,caspase-9以及切割的PARP 表达。 | |||
TN2006 |
Odoriflavene
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Others | Others |
Odoriflavene has antioxidant activity, and it also shows inhibition effects on the decrease of glutathione level of rat lens induced by UV irradiation. Odoriflavene shows cytotoxic activity against a SH-SY5Y cell line in vitro. | |||
TN6469 | Biatractylolide | ||
Biatractylolide has a neuroprotective effect on glutamate-induced injury in PC12 and SH-SY5Y cells through a mechanism of the PI3K-Akt-GSK3β-dependent pathways. The molecular mechanisms of inhibitory activities of biatractylolide on AChE are not only thro | |||
TN3614 |
Cearoin
檀木 |
ERK; BCL; PARP; IκB/IKK; TNF; NF-κB; ROS; Caspase | Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Immunology/Inflammation; MAPK; NF-κB; Proteases/Proteasome |
Cearoin has anti-inflammatory, and antiallergic activities, it can markedly inhibit inflammatory responses including LPS-induced NO production by suppressing the expression of iNOS mRNA and LPS-induced mRNA expression of TNFα and CCL2. Cearoin induces aut | |||
TN4394 |
Kobophenol A
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MMP; BCL; p38 MAPK; NF-κB; ROS; DNA/RNA Synthesis; CDK; JNK | Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Immunology/Inflammation; MAPK; NF-κB; Proteases/Proteasome |
Kobophenol A has antimicrobial, and anti-inflammatory activities, it might be a candidate for treatment of inflammatory bone diseases relevant to osteoblast cell death. Kobophenol A inhibits AChE activity in a dose-dependent manner, and the IC50 value is |