Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Mirodenafil 是一种磷酸二酯酶5(PDE-5)抑制剂,可用于勃起功能紊乱的研究。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 185 | 现货 | ||
5 mg | ¥ 413 | 现货 | ||
10 mg | ¥ 663 | 现货 | ||
25 mg | ¥ 1,230 | 现货 | ||
50 mg | ¥ 1,990 | 现货 | ||
100 mg | ¥ 3,190 | 现货 | ||
500 mg | ¥ 6,920 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 559 | 现货 |
产品描述 | Mirodenafil is a PDE-5 inhibitor developed for the treatment of erectile dysfunction. |
体外活性 | The pharmacoki-netics of mirodenafil were not significantly altered by this concurrent administration. Mirodenafil (50 or 100 mg), obviously improved erectile function and was well tolerated in a representative population of Korean men with broad-spectrum ED of various etiologies and severities [1]. Mirodenafil administered with alcohol had a tolerability profile comparable to that of mirodenafil alone [2]. The concurrent administration of mirodenafil with alcohol was not associated with clinically significant hemodynamic changes in these healthy male volunteers in Korea. The coadministration of ketoconazole and rifampicin resulted in significant changes in systemic exposure to mirodenafil, in these healthy Korean male volunteers [3]. |
别名 | 米罗那非, SK3530 |
分子量 | 531.67 |
分子式 | C26H37N5O5S |
CAS No. | 862189-95-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 27.5 mg/mL (51.72 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.8809 mL | 9.4043 mL | 18.8087 mL | 47.0216 mL |
5 mM | 0.3762 mL | 1.8809 mL | 3.7617 mL | 9.4043 mL | |
10 mM | 0.1881 mL | 0.9404 mL | 1.8809 mL | 4.7022 mL | |
20 mM | 0.094 mL | 0.4702 mL | 0.9404 mL | 2.3511 mL | |
50 mM | 0.0376 mL | 0.1881 mL | 0.3762 mL | 0.9404 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Mirodenafil 862189-95-5 Metabolism PDE Beta catenin SK-3530 Glucocorticoid Receptor Wnt Apoptosis 米罗那非 β-catenin inhibit systemic sclerosis NIH3T3 erectile dysfunction Alzheimer’s disease HT-22 cells SH-SY5Y MRC-5 cells fibrosis SK3530 Inhibitor SK 3530 Phosphodiesterase (PDE) inhibitor