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Search Results for " mda-231 "

120

抑制剂 & 化合物

31

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T8800	NSAH 2-hydroxy-N'-[(E)-(2-hydroxynaphthalen-1-yl)methylidene]benzohydrazide	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	NSAH (2-hydroxy-N'-[(E)-(2-hydroxynaphthalen-1-yl)methylidene]benzohydrazide) 是一种可逆竞争性非核苷类的核苷酸还原酶抑制剂，无细胞 IC50 为 32 μM，基于细胞的 IC50 约为 250 nM。
T8334	CADD522 MFCD00167693,3-{[(3,4-二氯苯基)氨基]羰基}二环[2.2.1]庚-5-烯-2-羧酸	Others	Others
	CADD522 (MFCD00167693) 是 runt 相关转录因子-2 (RUNX2)-DNA 结合的抑制剂(IC50:10 nM)，具有抗肿瘤作用。
T13009	STAT3-IN-1	Apoptosis; STAT	Apoptosis; JAK/STAT signaling; Stem Cells
	STAT3-IN-1 是一种选择性的、口服有效的 STAT3的强效抑制剂，可诱导肿瘤细胞凋亡，其在 HT29 和MDA-MB 231 细胞中的IC50值分别为1.82 μM 和2.14 μM。
T70353	JG-231	HSP	Cytoskeletal Signaling; Metabolism
	JG-231 是 JG-98 类似物，具有抗癌活性。JG-231 对三阴性乳腺癌 (TNBC) 的 MDA-MB-231 异植肿瘤模型具有抑制作用。JG-231 可抑制 Hsp70-BAG3 的相互作用。JG-231 对三阴性乳腺癌 (TNBC) 的 MDA-MB-231 异植肿瘤模型具有抑制作用。
T28865	STAT3-IN-B9 STAT3 IN B9,B9	STAT	JAK/STAT signaling; Stem Cells
	STAT3-IN-B9 (B9) 是异常 STAT3 激活的抑制剂，可抑制 MDA-MB-468、MDA-MB-231 和 DU145 等肿瘤细胞的增殖。
T5350	JG-98 JG98,JG 98	Apoptosis; HSP	Apoptosis; Cytoskeletal Signaling; Metabolism
	JG-98 是一种热休克蛋白 70 (Hsp70)变构抑制剂，可与 Hsp70 上的保守位点紧密结合，打断 Hsp70-Bag3 相互作用。它影响癌细胞和肿瘤相关巨噬细胞，具有抗癌活性。
T22538	A-7 hydrochloride	CaMK	Neuroscience
	A-7 hydrochloride 是一种钙调蛋白拮抗剂，会引起 MDA-MB-231细胞中 CD44+CD24-亚群的改变。
T60269	ZINC194100678	PAK	Cytoskeletal Signaling
	ZINC194100678是一种有效的PAK1抑制剂，IC50值为8.37μM 。ZINC194100678 具有较强的抗增殖活性，对MDA-MB-231的IC50值为40.16μM。ZINC194100678可用于癌症的研究。
T36488	LYG-202 LYG202,LYG 202	Apoptosis; ROS	Apoptosis; Immunology/Inflammation
	LYG-202是一种具有哌嗪替代的新型类黄酮，在体内和体外都具有抗肿瘤作用。LYG-202 诱导 MCF-7、MDA-MB-231 和 MDA-MB-435 细胞凋亡，增加了细胞内 ROS 的产生。
T12344L1	OTS186935 FA OTS186935 FA（2093400-18-9 Free base）	Histone Methyltransferase	Chromatin/Epigenetic
	OTS186935 FA 是一种蛋白甲基转移酶 SUV39H2 抑制剂。OTS186935 FA在 MDA-MB-231 乳腺癌细胞和 A549 肺癌细胞中抑制肿瘤的生长。
T2427	EHop-016 EHop 016	Rho; Ras	Cell Cycle/Checkpoint; GPCR/G Protein; MAPK
	EHop-016 是一种特异性 Rac GTPase 抑制剂，对 MDA-MB-231 和 MDA-MB-435 细胞中的 Rac1 的 IC50 为 1.1 μM，也可抑制Rac3 。它还抑制 Vav2 与 Rac，Rac 激活的 PAK1 相互作用，片状脂蛋白形成和细胞迁移。
T2060	ELR510444 LR-510444,LR510444,LR 510444	Apoptosis; Microtubule Associated	Apoptosis; Cytoskeletal Signaling
	ELR510444 (LR510444) 是一种新型微管破坏剂，抑制 MDA-MB-231 细胞增殖，IC50 为 30.9 nM。
T72924	VEGFR-3-IN-1	VEGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	VEGFR-3-IN-1 是一种新型有效且具有选择性的 VEGFR3 抑制剂，其 IC50 为 110.4 nM。VEGFR-3-IN-1 具有抗肿瘤活性，可使 VEGFR3 信号通路失活，可抑制 VEGF-C 诱导人真皮淋巴管内皮细胞 (HDLEC)、MDA-MB-231 和 MDA-MB-436 细胞的增殖和迁移，并且能有效抑制乳腺癌的生长。
T16021	MBQ-167	CDK; Ras	Cell Cycle/Checkpoint; GPCR/G Protein; MAPK
	MBQ-167 是一种 Rac/Cdc42 的双重抑制剂，在 MDA-MB-231 细胞中，Rac 1/2/3 和 Cdc42 的 IC50 分别为 103 nM 和 78 nM。
T77728	Tubulin polymerization-IN-55	Microtubule Associated	Cytoskeletal Signaling
	Tubulin polymerization-IN-55 是一种高效的 Tubulin Polymerization 抑制剂，具有潜在的抗血管生成和抗肿瘤活性，对 A549、K562、HepG2、MDA-MB-231 和 HFL-1 显示出抗增殖作用。
T2080	LCL161	IAP	Apoptosis
	LCL161 是一种 SMAC 模拟物，可有效结合并抑制多种 IAP。它抑制 HEK293 细胞中 XIAP 和 MDA-MB-231细胞中 cIAP1的 IC50分别为 35 和 0.4 nM。
T63140	LSD1-IN-20	Histone Demethylase	Chromatin/Epigenetic
	LSD1-IN-20 是一种有效的 LSD1/G9a 双重抑制剂，其 Ki 值分别为 0.44 和 0.68 μM。LSD1-IN-20 在体外实验中对 THP-1 白血病细胞和 MDA-MB-231 乳腺癌细胞显示出抗增殖活性，72 h 时 IC50 分别为 0.51 和 1.60 μM。
T60564	PI3K/Akt/mTOR-IN-2	Apoptosis; Akt; PI3K; mTOR	Apoptosis; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	PI3K/Akt/mTOR-IN-2 是一种有效的 PI3K/AKT/mTOR 抑制剂。PI3K/Akt/mTOR-IN-2 具有抗癌作用，并对 MDA-MB-231 细胞具有选择性，IC50 为 2.29 μM。PI3K/Akt/mTOR-IN-2 具有抗癌活性，可诱导癌细胞周期阻滞和细胞凋亡 (apoptosis)。
T60165	VB124	Monocarboxylate transporter	Membrane transporter/Ion channel
	VB124 是一种具有口服活性的、有效且选择性的MCT4抑制剂。VB124 可特异性抑制 MDA-MB-231 细胞中乳酸的涌入和流出，IC50分别为 8.6 nM 和 19 nM。VB124 对 MCT4 的选择性高于 MCT1。VB124可用于心脏肥大、心力衰竭和代谢的研究。
T2354	UNC 0631 UNC0631	Histone Methyltransferase	Chromatin/Epigenetic
	UNC 0631 是一种有效的组蛋白甲基转移酶 G9a 抑制剂，IC50值为 4 nM。它有效降低 MDA-MB-231 细胞中 H3K9me2的水平，IC50为 25 nM。
T35666	PRGL493	Others	Others
	PRGL493为高效、选择性的长链酰基辅酶a合成酶4 (ACSL4) 抑制剂，能在乳腺和前列腺细胞以及动物模型中抑制细胞增殖和肿瘤生长，主要应用于癌症研究。
TQ0232	UNC0646 UNC 0646	Histone Methyltransferase	Chromatin/Epigenetic
	UNC0646 是一种有效的、选择性的同源蛋白赖氨酸甲基转移酶 G9a 和 GLP 抑制剂，IC50分别为 6 和 15 nM，对 G9a/GLP 的选择性比 SETD7、SUV39H2、SETD8 和 PRMT3 高。它降低 MDA-MB-231 细胞中H3K9me2的水平，IC50为 26 nM。
T14084	ABL127	Others	Others
	ABL127 is a selective and covalent inhibitor of protein methylesterase 1 (PME-1). In HEK293T and MDA-MB-231 cells, the IC50s values are 6.4 nM and 4.2 nM , respectively.
T27524	H8-A5 H8 A5
	H8-A5, a HDAC8 inhibitor, shows antiproliferation activity in MDA-MB-231 cancer cells.
T73419	JMX0293
	JMX0293是一种O-烷基氨基连接的水杨酰胺衍生物化合物，具有针对MDA-MB-231细胞系的高效力(IC50=3.38 μM)，且对MCF-10A人非致瘤性乳腺上皮细胞系的毒性极低(IC50>60 μM)。该化合物能抑制STAT3磷酸化，促进TNBC MDA-MB-231细胞的凋亡，同时在体内显著抑制MDA-MB-231异种移植肿瘤的生长，无明显毒性。
T36194	CAY10726 CAY10726
	CAY10726 is an arylurea fatty acid. It decreases ATP production by 28% in MDA-MB-231 breast cancer cells when used at a concentration of 10 μM. CAY10726 decreases proliferation and initiates apoptosis in MDA-MB-231 cells via depletion of the phospholipid cardiolipin and its precursor phosphatidylglycerol from the mitochondrial membrane. In vivo, CAY10726 (2.5-40 mg/kg) reduces tumor volume and increases tumor cell apoptosis in a mouse MDA-MB-231 breast cancer xenograft model in a dose-dependent ...
T74512	PROTAC eEF2K degrader-1
	PROTACeEF2K Degrader-1 (Compound 11l) 是一种靶向eEF2K 的PROTAC 小分子，介导 eEF2K 降解，且诱导 MDA-MB-231 细胞凋亡 (apoptosis)。
T70703	DK-139
	DK-139 is an inhibitor of NF-kappaB-mediated GROalpha expression, suppressing the TNFalpha-induced invasive capability of MDA-MB-231 human breast cancer cells.
T34791	TCCP
	TCCP is a natural inducer of apoptosis in MDA-MB-231 breast cancer cells via ROS mediated mitochondrial damage and restoration of p53 activity.
T82999	Antitumor agent-93
	Antitumor agent-93 (化合物 7D) 为抗癌剂，对MDA-MB-231与HCT-116等多种肿瘤细胞系生长抑制效果显著。
T63913	Anticancer agent 41
	Anticancer agent 41 是一种有效的抗癌剂，对 MDA-MB-231 细胞表现出良好的抗肿瘤效果 (IC50: 3.99 μM)。
T61349	HIF-1α-IN-2	HIF	Angiogenesis; Chromatin/Epigenetic
	HIF-1α-IN-2 是一种新型高效的 HIF-1α 抑制剂，具有抗癌抗肿瘤活性，以剂量依赖的方式抑制 HIF-1α 和 VEGF 的表达，抑制细胞迁移。
T79347	Anticancer agent 146	Necroptosis	Apoptosis
	Anticanceragent 146（compound 1.19）是一种诱导坏死（Necroptosis）的化合物，它在小鼠MDA-MB-231异种移植模型中显示出抗肿瘤活性。
T70344	BJ-2302
	BJ-2302 is a SRC inhibitor. BJ-2302 effectively suppressed MDA-MB-231 cell invasion (Matrigel invasion assay) and metastasis (chorioallantoic membrane assay xenografted with MDA-MB-231-luc2-tdTomato cancer cells). Additionally, BJ-2302 (1 mg/kg) strongly suppressed TNBC cell proliferation in vitro and tumor growth in a xenograft mouse tumor model. The anti-metastatic and anti-tumor effects of BJ-2302 were superior to those of Z-FL-COCHO (1 mg/kg) or batimastat (30 mg/kg), a pan-MMP inhibitor.
T82935	AuM1Gly	Topoisomerase	DNA Damage/DNA Repair
	AuM1Gly 是拓扑异构酶 I (topoisomerase I) 的抑制剂，对 MDA-MB-231 乳腺癌细胞的增殖产生影响，表现出低纳摩尔范围的 IC50 值。
T10767	Cerivastatin sodium	HMG-CoA Reductase	Metabolism
	Cerivastatin sodium is a synthetic lipid-lowering agent and a highly potent and orally active HMG-CoA reductase inhibitor (Ki: 1.3 nM). It also inhibits the proliferation and invasiveness of MDA-MB-231 cells, mainly by RhoA inhibition.
T29172	YD277 YD 277,YD-277
	YD277 is a small molecule derived from ML264, a KLF5 inhibitor that elicits cytotoxic effects in colon cancer cell lines. YD277 significantly induced G1 cell cycle arrest and apoptosis in MDA-MB-231 and MDA-MB-468 TNBC cells, independent of KLF5 inhibitio
T69888	SB02024
	SB02024 is a VPS34 inhibitor. SB02024 activates cGAS-STING signaling and sensitizes tumors to STING agonist. SB02024 blocked autophagy in vitro and reduced xenograft growth of two breast cancer cell lines, MDA-MB-231 and MCF-7, in vivo. Vps34 inhibitor significantly potentiated cytotoxicity of Sunitinib and Erlotinib in MCF-7 and MDA-MB-231 in vitro in monolayer cultures and when grown as multicellular spheroids. Our data suggests that inhibition of autophagy significantly improves sensitivity...
T41146	ND1-YL2 ND1-YL2
	ND1-YL2 is a peptide-based PROTAC®Degrader of steroid receptor co-activator 1 (SRC-1; also known as nuclear receptor coactivator 1, NCOA1). ND1-YL2 is composed of a stapled peptide that binds SRC-1 (YL2) joined by a linker to a tetrapeptide that binds UBR box domains. Upon ternary complex formation, SRC-1 is polyubiquitinated and subsequently degraded via the N-degron pathway. This Degrader induces dose-dependent degradation of SRC-1 in the MDA-MB-231 triple negative breast cancer cell line (DC5...
T61582	Anticancer agent 57
	Anticancer agent 57 (compound 14) demonstrates potent inhibition of MDA-MB-231, MDA-MB-468, and MCF-7 cell lines, with IC 50 values ranging from 6.43 to 8.00 μM. Additionally, this agent induces cell cycle arrest and promotes apoptosis. In vivo studies using nude mice xenografted with MADMB-231 cells have shown that Anticancer agent 57 effectively inhibits tumor growth. Consequently, Anticancer agent 57 can serve as a valuable tool for researching triple negative breast cancer (TNBC) [1].
T39992	FGFR1 inhibitor-2 FGFR1 inhibitor-2
	FGFR1 inhibitor-2 (with an IC50 of 4.55 μM in MDA-MB-231 cells) is a potent inhibitor of FGFR1. It is specifically useful for studying metastatic triple-negative breast cancer.
T63527	RIDR-PI-103
	RIDR-PI-103 是活性氧 (ROS) 诱导的药物释放前药，含有与泛 PI3K 抑制剂 (PI-103) 连接的自环化部分。在 MDA-MB-361 和 MDA-MB-231 细胞中，Doxorubicin 和 RIDR-PI-103 表现出协同的抑制癌细胞增殖作用。
T79427	LM-41	YAP	Stem Cells
	LM-41是一种衍生自Flufenamic acid的TEAD抑制剂，能有效下调CTGF、Cyr61、Axl和NF2的表达水平。此外，LM-41抑制了人类MDA-MB-231乳腺癌细胞的迁移。
T63123	FAK inhibitor 6
	化合物26f 不仅优化了有效抑制酶（IC50= 28.2 nM），也表现出相对较少的细胞毒性（IC50= 3.32 μM），并以剂量依赖性方式诱导 MDA-MB-231细胞凋亡，有效阻断 G0/G1期MDA-MB-231细胞。
T36201	AZD5582 dihydrochloride AZD 5582 dihydrochloride
	Dimeric Smac mimetic; potent inhibitor of X-linked (XIAP) and cellular (cIAP) inhibitor of apoptosis protein (IC50 values are 15, 15 and 21 nM for XIAP, cIAP1 and cIAP2 respectively). Binds to the BIR3 domain of XIAP to prevent interaction with caspase-9. Causes degradation of cIAP1 and cIAP2 and induces apoptosis in MDA-MB-231 breast cancer cells. Causes tumor regression in MDA-MB-231 xenograft-bearing mice. Hennessy et al (2013) Discovery of a novel class of dimeric Smac mimetics as potent IAP...
T83011	Antitumor agent-105
	Antitumor agent-105（Compound 37）是一种对A549、H1299、H460、HCT116、MDA-MB-231细胞线显示出抗肿瘤活性的化合物，其IC50值分别为6.7、8.3、4.3、4.4、6.7μM。
T79651	EGFR-IN-83	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	EGFR-IN-83（化合物9）为EGFR抑制剂，IC50为2.53 nM。该化合物对MCF-7及MDA-MB-231细胞显示出抗增殖作用，其IC50值分别为2.50 μM及1.96 μM。此外，EGFR-IN-83能够诱导细胞凋亡。
T80923	Tubulin polymerization-IN-53
	Tubulin polymerization-IN-53 是一种β-tubulin聚合的抑制剂，能够阻断细胞周期于G2/M阶段。对MDA-MB-231细胞系显示出抗增殖作用，其IC50为3.24 μM。
T82089	ICMT-IN-53
	ICMT-IN-53 (compound 12)是ICMT抑制剂，IC50值为0.96 μM，展现出PAMPA渗透性及抗增殖效果。该化合物在抑制MDA-MB-231与PC3细胞增殖方面的IC50s分别为5.14 μM与5.88 μM。
T83087	Anticancer agent 158
	Anticanceragent 158 (compound 7c) 作为一种有效的抗癌剂，其对HepG-2、MDA-MB-231、HCT-116细胞系的IC50值分别为7.93 μM、9.28 μM、13.28 μM。

化合物

Cat.No: T8800

Synonym: 2-hydroxy-N'-[(E)-(2-hydroxynaphthalen-1-yl)methylidene]benzohydrazide

Target: DNA/RNA Synthesis

Cat.No: T8334

Synonym: MFCD00167693,3-{[(3,4-二氯苯基)氨基]羰基}二环[2.2.1]庚-5-烯-2-羧酸

Target: Others

Cat.No: T13009

Target: Apoptosis, STAT

Cat.No: T70353

Target: HSP

Cat.No: T28865

Synonym: STAT3 IN B9,B9

Target: STAT

Cat.No: T5350

Synonym: JG98,JG 98

Target: Apoptosis, HSP

A-7 hydrochloride

Cat.No: T22538

Target: CaMK

Cat.No: T60269

Target: PAK

Cat.No: T36488

Synonym: LYG202,LYG 202

Target: Apoptosis, ROS

Cat.No: T12344L1

Synonym: OTS186935 FA（2093400-18-9 Free base）

Target: Histone Methyltransferase

Cat.No: T2427

Synonym: EHop 016

Target: Rho, Ras

Cat.No: T2060

Synonym: LR-510444,LR510444,LR 510444

Target: Apoptosis, Microtubule Associated

Cat.No: T72924

Target: VEGFR

Cat.No: T16021

Target: CDK, Ras

Tubulin polymerization-IN-55

Cat.No: T77728

Target: Microtubule Associated

Cat.No: T2080

Target: IAP

Cat.No: T63140

Target: Histone Demethylase

PI3K/Akt/mTOR-IN-2

Cat.No: T60564

Target: Apoptosis, Akt, PI3K, mTOR

Cat.No: T60165

Target: Monocarboxylate transporter

Cat.No: T2354

Synonym: UNC0631

Target: Histone Methyltransferase

Cat.No: T35666

Target: Others

Cat.No: TQ0232

Synonym: UNC 0646

Target: Histone Methyltransferase

Cat.No: T14084

Target: Others

Cat.No: T27524

Synonym: H8 A5

Cat.No: T73419

Cat.No: T36194

Synonym: CAY10726

PROTAC eEF2K degrader-1

Cat.No: T74512

Cat.No: T70703

Cat.No: T34791

Antitumor agent-93

Cat.No: T82999

Anticancer agent 41

Cat.No: T63913

Cat.No: T61349

Target: HIF

Anticancer agent 146

Cat.No: T79347

Target: Necroptosis

Cat.No: T70344

Cat.No: T82935

Target: Topoisomerase

Cerivastatin sodium

Cat.No: T10767

Target: HMG-CoA Reductase

Cat.No: T29172

Synonym: YD 277,YD-277

Cat.No: T69888

Cat.No: T41146

Synonym: ND1-YL2

Anticancer agent 57

Cat.No: T61582

FGFR1 inhibitor-2

Cat.No: T39992

Synonym: FGFR1 inhibitor-2

Cat.No: T63527

Cat.No: T79427

Target: YAP

FAK inhibitor 6

Cat.No: T63123

AZD5582 dihydrochloride

Cat.No: T36201

Synonym: AZD 5582 dihydrochloride

Antitumor agent-105

Cat.No: T83011

Cat.No: T79651

Target: EGFR

Tubulin polymerization-IN-53

Cat.No: T80923

Cat.No: T82089

Anticancer agent 158

Cat.No: T83087

Cat. No.	Product Name	Target	Signaling Pathways
T5S1000	Sophoraflavanone G Kushenol F,槐黄烷酮 G,Vexibinol	Apoptosis	Apoptosis
	Sophoraflavanone G (Kushenol F) 是从苦参中提取到的一种天然产物，通过抑制 MAPK 相关通路诱导 MDA-MB-231 和 HL-60 细胞凋亡，具有抗肿瘤和抗炎特性。
T3844	Deltonin 三角叶薯蓣皂苷	ERK; Others; Akt; Endogenous Metabolite	Cytoskeletal Signaling; MAPK; Metabolism; Others; PI3K/Akt/mTOR signaling
	Deltonin 是从盾叶薯蓣中得到的一种甾体皂苷，抑制ERK1/2和AKT 的活化，具有抗肿瘤活性。
T10390	Asperphenamate	Others; Antifungal	Microbiology/Virology; Others
	Asperphenamate 是 Aspergillus flatiipes 的真菌代谢产物。 T47D 细胞、MDA-MB-231 细胞和 HL-60 细胞的 IC50 分别为 92.3 μM、96.5 μM 和 97.9 μM。 Asperphenamate 具有抗癌作用。
T21771	Pyoluteorin	Antibiotic	Microbiology/Virology
	Pyoluteorin 是一种抗生素 (antibiotic)，可抑制 Oomycete fungi，包括植物病原体 Oomycete fungi，并抑制由该真菌引起的植物病害。 Pyoluteorin 在体外诱导人三阴性乳腺癌 MDA-MB-231 细胞凋亡 (apoptosis)。 Pyoluteorin 可用于人类三阴性乳腺癌的研究。
TN2083	Pinostrobin chalcone 球松素查尔酮,2',3'-二羟基-4'-甲氧基查耳酮
	Pinostrobin chalcone 是一种从豆科植物木豆中分离出的查尔酮类化合物，具有抗癌活性，对 MDA-MB-231 的 IC50 值为 20.42±2.23μg/mL，对 HT-29 结肠癌细胞株的IC50 值为 22.51±0.42 μg/mL。
T4519	Alisol A Alisol-A,泽泻醇 A	Autophagy	Autophagy
	Alisol A (Alisol-A) 是泽泻中的一种三萜类天然产物，可能是一种自噬诱导剂，具有抗癌活性。
T2896	Alantolactone 土木香内酯,helenin,Eupatal,Helenine,(+)-Alantolactone,Alant camphor,土木香脑,Inula camphor	Apoptosis; STAT; TGF-beta/Smad	Apoptosis; JAK/STAT signaling; Stem Cells
	Alantolactone (Inula camphor) 是一种STAT3的选择性抑制剂，可诱导癌症相关的凋亡，具有抗肿瘤活性。
T5S1607	Morusin Mulberrochromene,桑辛素	NF-κB; Antibacterial; STAT	JAK/STAT signaling; Microbiology/Virology; NF-κB; Stem Cells
	Morusin (Mulberrochromene) 是从M. australis 分离的去乙烯基化黄酮，可抑制NF-κB 和STAT3的活性，具有抗菌、抗肿瘤、抗氧化等各种生物活性。
T5S1331	Herbacetin	c-Met/HGFR; Akt	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	Herbacetin 是一种亚麻籽中的天然类黄酮，具有多种药理活性，如抗氧化、抗炎、抗癌作用。它是鸟氨酸脱羧酶Ornithine decarboxylase (ODC)变构抑制剂，能够直接与 ODC 上的 Asp44，Asp243 和 Glu384 结合。其中鸟氨酸脱羧酶是多胺生物合成中的限速酶。
T4964	steviolbioside CCRIS-6025,菊双糖甙,甜菊双糖苷	Others	Others
	Steviolbioside (CCRIS-6025) 是一种存在于甜菊叶中的罕见甜味剂。它对几种人类癌细胞有抑制作用，对乳腺癌具有潜在的研究价值。
T2973	Astragaloside IV AST-IV,黄芪甲苷IV,AS-IV,黄芪皂苷 IV	MMP; ERK; Estrogen/progestogen Receptor; JNK	Endocrinology/Hormones; MAPK; Proteases/Proteasome
	Astragaloside IV (AS-IV) 是从黄芪中分离得到的一种皂苷，抑制ERK1/2和JNK 激活，在乳腺癌细胞 MDA-MB-231 中，下调(MMP)-2和(MMP)-9的信号通路。
T2966	Beta-Sitosterol Cupreol,谷甾醇,Beta-Sitosterol,β-Sitosterol,Azuprostat,SKF 14463,beta-谷甾醇,22,23-Dihydrostigmasterol,Betaprost	Apoptosis; Lipase; Endogenous Metabolite	Apoptosis; Metabolism
	Beta-Sitosterol (SKF 14463) 是一种植物甾醇，干扰细胞周期、细胞凋亡、增殖、存活、侵袭、血管生成和炎症等多种细胞信号通路。
T5S0055	Chelidonine Helidonine,Khelidonin,白屈菜碱,Stylophorin	Apoptosis; Others; Influenza Virus	Apoptosis; Microbiology/Virology; Others
	Chelidonine (Stylophorin) 是白屈菜中的一种异喹啉生物碱，有抗肿瘤和抗病毒作用。它可导致细胞周期 G2/M 停滞，诱导 caspase 依赖和非依赖性的细胞凋亡。
T3908	10-Gingerol 10-姜酚	Apoptosis	Apoptosis
	10-Gingerol 是一种姜根脂的主要刺激性成分，具有抗炎、抗氧化和抗增殖作用，能够抑制 MDA-MB-231 肿瘤细胞的增殖(IC50:12.1 μM)。
T5S0053	Coptisine 黄连碱,Coptisin	Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	Coptisine (Coptisin) 是一种从黄连中分离到的生物碱，是非竞争性的IDO 抑制剂，Ki=为 5.8 μM，IC50=6.3 μM。
T3729	Ethyl gallate Nipagallin A,Phyllemblin,gallic acid ethyl ester,没食子酸乙酯	MMP; NF-κB; Akt; Antibacterial	Cytoskeletal Signaling; Microbiology/Virology; NF-κB; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Ethyl gallate (gallic acid ethyl ester) 是一种非类黄酮酚过氧化氢清除剂。
T2S1865	Octyl gallate Gallic acid octyl ester,n-Octylgallate,Octyl 3,4,5-trihydroxybenzoate,Progallin O,Stabilizer GA-8,没食子酸辛酯	Antioxidant; Influenza Virus; Reactive Oxygen Species; Antibacterial; Antifungal; HSV	Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB; oxidation-reduction
	Octyl gallate (Octyl 3,4,5-trihydroxybenzoate) 具有抗菌、抗氧化作用，有选择性和敏感性的荧光特性，广泛用作食品添加剂。它对 HSV-1，水泡性口炎病毒和脊髓灰质炎病毒有显著的抗病毒作用。
TN1493	Chrysosplenol D 猫眼草酚D	IL Receptor; NF-κB; JNK	Immunology/Inflammation; MAPK; NF-κB
	Chrysosplenol D 属于甲氧基黄酮类化合物，可诱导 ERK1/2 介导的三阴性人乳腺癌细胞凋亡。它还显示出抗炎和中等抗锥虫活性。
T83104	Anthragallol 1,2-dimethyl ether
	Anthragallol 1,2-dimethyl ether 可从O. umbellata提取。该化合物对A549细胞和MDA-MB-231细胞展现细胞毒性，IC50值分别为5.9 μg/ml和8.8 μg/ml。
TN4330	Isoshinanolone	Others	Others
	Isoshinanolone shows excellent toxicity with LC(50) values of 1.26 microg/mL. trans-Isoshinanolone shows cytotoxicity against MDA-MB-231 breast cancer cells.
TN1392	Anhydrosecoisolariciresinol	Others	Others
	Anhydrosecoisolariciresinol can significantly decrease the growth of human breast cancer MCF-7 and MDA-MB-231 cell lines at 50 and 100 microM.
T82344	Gambogic acid B
	Gambogic acid B，一种从Garcinia hanburyi树脂中分离得到的活性化合物，对A549、HCT116 和 MDA-MB-231 细胞显示细胞毒性，其IC50值分别为1.60 μM、6.88 μM 和 0.87 μM。
TN2752	2-Deacetoxytaxinine J	Others	Others
	2-Deacetoxytaxinine J shows significant in vitro activity against breast cancer cell line at a concentration of 20 microM and 10 microM in MCF-7 and MDA-MB-231 respectively.
TN1741	Homomangiferin 高芒果苷	Others	Others
	Homomangiferin has important medicinal properties and is widely used to relieve many symptoms, for example coughing and asthma.Homomangiferin shows antitumoural effects against MDA-MB-231 cells.
TMA1944	Protopine hydrochloride	EGFR; cAMP	Angiogenesis; GPCR/G Protein; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Protopine has antiplatelet effects,which is due to inhibition on thromboxane formation and phosphoinositides breakdown and then lead to the decrease of intracellular calcium concentration.Protopine seems to inhibit the heterotypic cell adhesion between MD
TN3401	Altenuene	Antifection	Microbiology/Virology
	Altenuene 是一种霉菌毒素，经常出现在被链格孢属真菌侵染的食物和饲料中。 Altenuene 表现出对金黄色葡萄球菌的中等活性。 Altenuene 还表现出对肺癌细胞系 A549、乳腺癌细胞系 MDA-MB-231 和胰腺癌细胞系 PANC-1 的细胞毒活性。
T2902	Costunolide Costus lactone,NSC 106404,Costunolid,(+)-Costunolide,木香烃内酯	Apoptosis; Endogenous Metabolite; Telomerase	Apoptosis; DNA Damage/DNA Repair; Metabolism
	Costunolide (Costus lactone) 是一种天然的倍半萜内酯，具有抗氧化、抗炎、抗过敏、骨重塑、神经保护、促进毛发生长、抗癌和抗糖尿病的特性，可诱导乳腺癌细胞周期阻滞和凋亡。
TN4261	Isoaltenuene	Antifection	Microbiology/Virology
	Isoaltenuene shows antibiotic activity against Gram-positive bacteria; it also shows a minor phytotoxic activity on tomato leaves at level of 20 ug/spot . Isoaltenuene exhibits cytotoxic activity against lung cancer cell line A549, breast cancer cell line
T35758	Butyrolactone V
	Butyrolactone V is a fungal metabolite that has been found in A. terreus and has antiprotozoal, antioxidant, and anticancer activities.1,2,3 It is active against the P. falciparum strain K1 (IC50 = 7.9 μg/ml) and L. amazonensis promastigotes (IC50 = 23.7 μM).2,1 Butyrolactone V (227 and 454.1 μM) is also active against adult S. mansoni worms.1 It scavenges 2,2-diphenyl-1-picrylhydrazyl and ABTS radicals with IC50 values of 20.7 and 3.7 μM, respectively, in cell-free assays.3 Butyrolactone V also...
T36448	(E)-Ajoene
	(E)-Ajoene is a disulfide that has been found inA. sativumand has diverse biological activities.1,2,3,4It is active against Gram-positive and Gram-negative bacteria (MICs = 10-250 and 150->500 μg/ml, respectively) and fungi (MICs = 15-50 μg/ml).1(E)-Ajoene inhibits proliferation of a variety of cancer cells, including MDA-MB-231 breast, HeLa cervical, and WHCO1 esophageal cancer cells (IC50s = 18.6, 61, and 39.2 μM, respectively).2It also inhibits human glutathione reductase andT. cruzitrypanoth...
TN3616	Cedrelone	Apoptosis; MMP; Antifection	Apoptosis; Microbiology/Virology; Proteases/Proteasome
	Cedrelone 是一种柠檬苦素类化合物，是一种吩嗪生物合成样结构域蛋白 (PBLD) 激活剂。Cedrelone 可诱导癌细胞凋亡 (apoptosis)。Cedrelone 是一种非常有效的细胞凋亡诱导剂，它能导致细胞周期停止。Cedrelone 具有杀虫活性，可抑制 P. saucia 的箭毒生长，并可抑制乳草蝽（Oncopeltus fasciatus）的蜕皮。Cedrelone具有抗肿瘤作用，对SMMC-7721、A-549、MCF-7 和 SW480 等癌细胞株具有显著的细胞毒性。

天然产物

Sophoraflavanone G

Cat.No: T5S1000

Synonym: Kushenol F,槐黄烷酮 G,Vexibinol

Target: Apoptosis

Cat.No: T3844

Synonym: 三角叶薯蓣皂苷

Target: ERK, Others, Akt, Endogenous Metabolite

Cat.No: T10390

Target: Others, Antifungal

Cat.No: T21771

Target: Antibiotic

Pinostrobin chalcone

Cat.No: TN2083

Synonym: 球松素查尔酮,2',3'-二羟基-4'-甲氧基查耳酮

Cat.No: T4519

Synonym: Alisol-A,泽泻醇 A

Target: Autophagy

Cat.No: T2896

Synonym: 土木香内酯,helenin,Eupatal,Helenine,(+)-Alantolactone,Alant camphor,土木香脑,Inula camphor

Target: Apoptosis, STAT, TGF-beta/Smad

Cat.No: T5S1607

Synonym: Mulberrochromene,桑辛素

Target: NF-κB, Antibacterial, STAT

Cat.No: T5S1331

Target: c-Met/HGFR, Akt

Cat.No: T4964

Synonym: CCRIS-6025,菊双糖甙,甜菊双糖苷

Target: Others

Astragaloside IV

Cat.No: T2973

Synonym: AST-IV,黄芪甲苷IV,AS-IV,黄芪皂苷 IV

Target: MMP, ERK, Estrogen/progestogen Receptor, JNK

Beta-Sitosterol

Cat.No: T2966

Synonym: Cupreol,谷甾醇,Beta-Sitosterol,β-Sitosterol,Azuprostat,SKF 14463,beta-谷甾醇,22,23-Dihydrostigmasterol,Betaprost

Target: Apoptosis, Lipase, Endogenous Metabolite

Cat.No: T5S0055

Synonym: Helidonine,Khelidonin,白屈菜碱,Stylophorin

Target: Apoptosis, Others, Influenza Virus

Cat.No: T3908

Synonym: 10-姜酚

Target: Apoptosis

Cat.No: T5S0053

Synonym: 黄连碱,Coptisin

Target: Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: T3729

Synonym: Nipagallin A,Phyllemblin,gallic acid ethyl ester,没食子酸乙酯

Target: MMP, NF-κB, Akt, Antibacterial

Cat.No: T2S1865

Synonym: Gallic acid octyl ester,n-Octylgallate,Octyl 3,4,5-trihydroxybenzoate,Progallin O,Stabilizer GA-8,没食子酸辛酯

Target: Antioxidant, Influenza Virus, Reactive Oxygen Species, Antibacterial, Antifungal, HSV

Chrysosplenol D

Cat.No: TN1493

Synonym: 猫眼草酚D

Target: IL Receptor, NF-κB, JNK

Anthragallol 1,2-dimethyl ether

Cat.No: T83104

Cat.No: TN4330

Target: Others

Anhydrosecoisolariciresinol

Cat.No: TN1392

Target: Others

Gambogic acid B

Cat.No: T82344

2-Deacetoxytaxinine J

Cat.No: TN2752

Target: Others

Cat.No: TN1741

Synonym: 高芒果苷

Target: Others

Protopine hydrochloride

Cat.No: TMA1944

Target: EGFR, cAMP

Cat.No: TN3401

Target: Antifection

Cat.No: T2902

Synonym: Costus lactone,NSC 106404,Costunolid,(+)-Costunolide,木香烃内酯

Target: Apoptosis, Endogenous Metabolite, Telomerase

Cat.No: TN4261

Target: Antifection

Butyrolactone V

Cat.No: T35758

Cat.No: T36448

Cat.No: TN3616

Target: Apoptosis, MMP, Antifection

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