263
81
Cat. No. | Product Name | Target | Signaling Pathways |
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T9836 |
(E)-SI-2
|
Others | Others |
(E)-SI-2 是类固醇受体 coactivator-3(SRC-3 或 AIB1)的有效小分子抑制剂,可选择性抑制 SRC-3 的内在转录活性,也抑制 SRC-1 和 SRC-2。它选择性地降低 SRC-3 的细胞蛋白水平,但不降低 CARM-1 的细胞蛋白水平,阻断 MDA-MB-468 细胞生长,IC50 值为 3.4 nM,但不影响正常细胞。 | |||
T68168L |
(2E,2'E)-Upenazime
|
||
Upenazime 是诊断成像的非放射性的前体试剂。 | |||
T7332 |
(E)-2-Decenoic acid
trans-2-Decenoic acid,反式-2-癸烯酸 |
Others | Others |
(E)-2-Decenoic acid (trans-2-Decenoic acid) 是一种存在于蜂王浆中的脂肪酸。 | |||
T67743 |
4-Pyridinecarboxaldehyde, 2-(2-pyridinyl)hydrazone, [C(E)]-
|
Others | Others |
4-Pyridinecarboxaldehyde, 2-(2-pyridinyl)hydrazone, [C(E)]-是混合配体配位聚合物[Zn4(bdc)4(ppmh)2(H2O)]n 的配体。 | |||
T9307 |
(E)-3-(3,4-dichlorophenyl)-N-(2-(4-(methylsulfonyl)piperazin-1-yl)-2-oxoethyl)acrylamide
|
Others | Others |
SR18662 又名 SR18662 ,是一种KLF5 抑制剂, 基于ML264结构的优化而得。它在体内外抑制结直肠癌的生长。 | |||
T9311 |
4-[(E)-{[4,6-Di(4-morpholinyl)-1,3,5-triazin-2-yl]hydrazono}methy l]-2,6-dimethoxyphenol
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Others | Others |
4-[(E)-{[4,6-Di(4-morpholinyl)-1,3,5-triazin-2-yl]hydrazono}methy l]-2,6-dimethoxyphenol 可用于化学和生命科学领域的研究。 | |||
T19589 |
trans-2-Undecenoic acid
(E)-2-Undecenoic acid,反-2-十一烯酸,(E)-Undec-2-enoic acid |
Others | Others |
trans-2-Undecenoic acid ((E)-Undec-2-enoic acid) 是一种 α,β-不饱和羧酸,其特征在于酸二聚体,相应的二聚体通过羧基 C=O···H-O 的分子间氢键连接。 | |||
T9449 |
Nitrofural
[(E)-(5-nitrofuran-2-yl)methylideneamino,(E)-2-((5-硝基呋喃-2-基)亚甲基)肼甲酰胺 |
Antibacterial | Microbiology/Virology |
Nitrofural 是 20 世纪已在临床应用中确立的硝基呋喃。 Nitrofural 在临床上对广泛的革兰氏阳性和革兰氏阴性细菌(包括许多常见的泌尿道病原体菌株)仍然有效。 | |||
T1865 |
S1RA
E-52862,4-(2-((5-甲基-1-(2-萘基)-1H-吡唑-3-基)氧基)乙基)吗啉 |
Sigma receptor | GPCR/G Protein |
S1RA (E-52862) 是一种有效且特异性的 sigma-1受体拮抗剂,Ki 为17nM,对 σ2R 具有良好的选择性,Ki 值大于 1000 nM。 | |||
T10761 |
Ceranib-2
3-[(E)-3-(4-hydroxyphenyl)prop-2-enoyl]-4-phenyl-1H-quinolin-2-one |
Apoptosis; S1P Receptor | Apoptosis; GPCR/G Protein |
Ceranib-2 (3-[(E)-3-(4-hydroxyphenyl)prop-2-enoyl]-4-phenyl-1H-quinolin-2-one) 是一种神经酰胺酶抑制剂,在 SKOV3 细胞中的 IC50 为 28 μM。 Ceranib-2 降低鞘氨醇和 S1P 的水平,诱导细胞凋亡并表现出抗癌活性。 | |||
T10859 |
COH34
1-[(E)-(4-methylphenyl)sulfanyliminomethyl]naphthalen-2-ol |
Others | Others |
COH34 (1-[(E)-(4-methylphenyl)sulfanyliminomethyl]naphthalen-2-ol) 是一种特异性的 PARG 抑制剂,IC50 为 0.37 nM,Kd 为 0.547 μM。 COH34 延长 DNA 损伤处的 PARylation 并捕获 DNA 修复因子。 | |||
T8800 |
NSAH
2-hydroxy-N'-[(E)-(2-hydroxynaphthalen-1-yl)methylidene]benzohydrazide |
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
NSAH (2-hydroxy-N'-[(E)-(2-hydroxynaphthalen-1-yl)methylidene]benzohydrazide) 是一种可逆竞争性非核苷类的核苷酸还原酶抑制剂,无细胞 IC50 为 32 μM,基于细胞的 IC50 约为 250 nM。 | |||
T36610 |
(E)-2-(2-Chlorostyryl)-3,5,6-trimethylpyrazine
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(E)-2-(2-Chlorostyryl)-3,5,6-trimethylpyrazine (CSTMP) is a stilbene derivative with antioxidant and anticancer activities. It stimulates proliferation of hydrogen peroxide-damaged ECV-304 cells (EC50 = 24.9 nM). CSTMP reduces hydrogen peroxide-induced release of lactate dehydrogenase (LDH) in and increases viability of human umbilical vein endothelial cells (HUVECs) in a concentration-dependent manner via inhibition of apoptosis. It reverses hydrogen peroxide-induced release of malondialdehyde ... | |||
T8368 |
Geranylacetone(Z/E)
6,10-二甲基-5,9-十一双烯-2-酮,Dihydropseudoionone |
Others | Others |
Geranylacetone(Z/E) (Dihydropseudoionone) 是一种天然存在的化合物,存在于许多植物的精油中,包括迷迭香、薰衣草和茉莉花。它具有抗氧化、抗炎和抗微生物的特性。 | |||
T4229 |
S1RA hydrochloride
4-[2-[[5-甲基-1-(2-萘基)-1H-吡唑-3-基]氧基]乙基]吗啉盐酸盐(1:1),E-52862 hydrochloride |
Sigma receptor | GPCR/G Protein |
S1RA hydrochloride (E-52862 hydrochloride) 是一种有效且特异性的 sigma-1受体拮抗剂,Ki 为17nM,对 σ2R 具有良好的选择性,Ki 值大于 1000 nM。 | |||
T9943 |
Firefly luciferase-IN-1
|
Others | Others |
Firefly luciferase-IN-1 是一种 2-亚苄基四氢萘酮衍生物,可在试剂盒中用作萤火虫荧光素酶抑制剂。 | |||
T9879 |
Hydroxystilbamidine
Oxistilbamidinum,羟芪巴脒,(E)-hydroxystilbamidine,2-Hydroxy-4,4'-diguanylstilbene,Bis(8-hydroxyquinolinium) sulphate |
Others | Others |
Hydroxystilbamidine ((E)-hydroxystilbamidine) 是一种能够结合 DNA 和 RNA 的染料, 也被发现是细胞核糖核酸酶的强效抑制剂。 | |||
T31275 |
Dec-2-enal, 4-oxo-, (E)-
4-Oxo-(E)-2-decenal,(E)-4-Oxodec-2-enal |
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Dec-2-enal, 4-oxo-, (E)- is comone of the volatile seretion componetnts of stink bugs. | |||
T8434 |
SIB-1757
6-methyl-2-[(E)-phenyldiazenyl]pyridin-3 |
GluR | Neuroscience |
SIB-1757 (6-methyl-2-[(E)-phenyldiazenyl]pyridin-3) 是高选择性非竞争性 mGlu5 受体拮抗剂 (IC50:0.4 μM) 。 | |||
T36837 |
(E,Z)-2-propyl-2-Pentenoic Acid
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(E,Z)-2-propyl-2-Pentenoic acid is a bioactive metabolite of valproic acid that exhibits the same profile and potency of anticonvulsant activity in animal models as its parent compound without any observed teratogenicity and hepatotoxicity. | |||
T35439 |
(E)-5-(2-Bromovinyl)uracil
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(E)-5-(2-Bromovinyl)uracil (BVU) is a pyrimidine base and an inactive metabolite of the antiviral agents sorivudine and (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) that may be regenerated to BVDU in vivo. BVU irreversibly inactivates dihydropyrimidine dehydrogenase (DPD) in an NADPH-dependent manner. It enhances the efficacy of the chemotherapeutic agent and DPD substrate 5-fluorouracil in a P388 murine leukemia model when administered at a dose of 200 μmol/kg, increasing survival time. | |||
T9398 |
NSC 73150
NSC 97967 |
Others | Others |
6-methyl-2-[2-[(E)-(6-oxo-1-cyclohexa-2,4-dienylidene)methyl]hydraziny l]-1H-pyrimidin-4-one (NSC 73150) 是一种嘧啶衍生物,具有抗肿瘤活性,临床前研究表明,它可以抑制各种肿瘤细胞系的生长,包括乳腺癌、肺癌和肝癌,也被发现可诱导细胞凋亡、抑制血管生成和抑制肿瘤转移。 | |||
T14880 |
CB-7921220
6-[2-(4-Aminophenyl)vinyl]-2-pyridinecarboxylic acid,6-(4-Aminostyryl)picolinic acid,6-[(E)-2-(4-aminophenyl)ethenyl]pyridine-2-carboxylic acid |
AChR | Neuroscience |
CB-7921220 (6-[2-(4-Aminophenyl)vinyl]-2-pyridinecarboxylic acid)是一种腺苷酸环化酶的抑制剂。 | |||
T15184 |
E 2012
(E)-1-[(1S)-1-(4-氟苯基)乙基]-3-[3-甲氧基-4-(4-甲基-1H-咪唑-1-YL)亚苄基]哌啶-2-酮 |
Gamma-secretase | Neuroscience; Proteases/Proteasome; Stem Cells |
E 2012 是一种γ 分泌酶调节剂,不会影响 Notch 加工,在胆固醇生物合成的末步抑制 3β-羟基固醇 Δ24-还原酶。它能够减少淀粉样蛋白 β-42 减少阿兹海默氏病,并在大鼠多次重复给药后诱发白内障。 | |||
T26631L |
Anidoxime HCl
USVP-E142,Anidoxime HCl( 34297-34-2 Free base) |
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Anidoxime HCl (USVP-E142) 是一种新型可口服的具有抗镇痛活性的化合物。 | |||
T8741 |
MitoBloCK-10
3-fluoro-N'-[(E)-(5-nitrothiophen-2-yl)m |
Others | Others |
MitoBloCK-10 (3-fluoro-N'-[(E)-(5-nitrothiophen-2-yl)m) 是第一个能够减弱PAM 复合体活性的小分子调节剂,对 C 末端结构域的Tim44与前体和 Hsp70 结合具有抑制作用。 | |||
T40693 | (E)-2,3-Dibromo-2-butenedioic acid | ||
(E)-2,3-Dibromo-2-butenedioic acid is a brominated haloacid that belongs to the category of drinking water disinfection byproducts (DBPs). | |||
T25150 |
BI-69A11
BI 69A11,(E)-3-(1H-Benzo[d]imidazol-2-yl)-1-(6-chloro-2-hydroxy-4-phenylquinolin-3-yl)prop-2-en-1-one |
NF-κB; Akt | Cytoskeletal Signaling; NF-κB; PI3K/Akt/mTOR signaling |
BI-69A11 ((E)-3-(1H-Benzo[d]imidazol-2-yl)-1-(6-chloro-2-hydroxy-4-phenylquinolin-3-yl)prop-2-en-1-one) 是一种双重 AKT 和 NFkB 通路抑制剂。它通过靶向 Akt 增强结肠癌细胞对 mda-7/IL-24 诱导的生长抑制的敏感性。 | |||
T7948 |
HPGDS inhibitor 2
GSK-2894631A |
PGE Synthase | Immunology/Inflammation |
HPGDS inhibitor 2 (GSK-2894631A) 是高效的造血前列腺素 D 合成酶(H-PGDS)选择性抑制剂(IC50:9.9 nM)。 | |||
T7198 |
E-4031
(1S)-1,5-脱水-1-C-[4-氯-3-[[4-[2-(环丙氧基)乙氧基]苯基]甲基]苯基]-D-山梨醇 |
EGFR; Potassium Channel | Angiogenesis; JAK/STAT signaling; Membrane transporter/Ion channel; Tyrosine Kinase/Adaptors |
E-4031是甲磺酰苯胺III 类抗心律失常药,选择性地阻断hERG 钾通道。 | |||
T36508 |
trans-4,5-epoxy-2(E)-Decenal
trans-4,5-epoxy-2(E)-Decenal,3-(3-pentyloxiranyl)-2E-propenal |
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Polyunsaturated fatty acids such as arachidonate and linoeate, while essential to health maintenance, are subject to random peroxidation by ambient oxygen, resulting in fragmented and reactive decomposition products. One prominent autoxidation product of either trilinolein or arachidonic acid is trans-4,5-epoxy-2(E)-decenal. One prominent autoxidation product of either trilinolein or arachidonic acid is trans-4,5-epoxy-2(E)-decenal. This aldehyde is responsible for a pungent metallic flavor of d... | |||
T13488 |
2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide
2-_E-2-decenoylamino_ethyl_2-_cyclohexylethyl__sulfide |
Prostaglandin Receptor | GPCR/G Protein; Immunology/Inflammation |
2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide is a compound known to inhibit stress-induced ulcers, effectively maintaining the levels of phospholipase A2 and prostaglandin E2 in rats subjected to water immersion-restrained stress-induced ulceration. | |||
T9409 |
Mesdopetam hemitartrate
IRL790 hemitartrate,1-Propanamine, N-[2-[3-fluoro-5-(methylsulfonyl)phenoxy]ethyl]-, (2R,3R)-2,3-dihydroxybutanedioate (2:1) |
Dopamine Receptor | GPCR/G Protein; Neuroscience |
Mesdopetam hemitartrate (IRL790 hemitartrate) 是一种多巴胺D3受体拮抗剂 (Ki=90 nM;IC50=9.8 μM),具有稳定精神运动的作用,可用于帕金森病的运动和精神并发症的研究。 | |||
T7417 |
Avatrombopag
YM477,AKR-501,1-[3-氯-5-[[[4-(4-氯-2-噻吩基)-5-(4-环己基-1-哌嗪基)-2-噻唑基]氨基]羰基]-2-吡啶基]-4-哌啶羧酸,E5501 |
Thrombin; Thrombopoietin Receptor | Immunology/Inflammation; Proteases/Proteasome |
Avatrombopag (YM477) 是一种新型口服血小板生成素 (TPO) 受体激动剂,可激活 TPO 受体并增加巨核细胞增殖/分化和血小板生成。 | |||
T7353 |
RSV604
(S)-1-(2-Fluorophenyl)-3-(2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)urea |
RSV | Microbiology/Virology |
RSV604 ((S)-1-(2-Fluorophenyl)-3-(2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)urea) 是一种呼吸道合胞病毒抑制剂,可与 RSV 核蛋白结合,靶向核衣壳蛋白的 Kd 值为 1.6 μM。它对 RSV A 和 B 亚型的众多临床分离株有亚微摩尔活性,EC50平均值为 0.8 μM。 | |||
T64398 |
(e)-3-(3,4-dihydroxyphenyl)-n-(2-(3,4-dihydroxyphenyl)ethyl)-2-propenamide
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Others | Others |
(e)-3-(3,4-dihydroxyphenyl)-n-(2-(3,4-dihydroxyphenyl)ethyl)-2-propenamide 能够以多种方式与蛋白质和其他分子相互作用,已被用于研究蛋白质-蛋白质相互作用以及酶-底物相互作用。 | |||
T30728 |
Carbanilic acid, m-hexyloxy-, 2-(diethylamino)cyclohexyl ester, hydrochloride, (E)-
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Carbanilic acid, m-hexyloxy-, 2-(diethylamino)cyclohexyl ester, hydrochloride, (E)- is a bioactive chemical. | |||
T30730 |
Carbanilic acid, m-hexyloxy-, 2-piperidinocyclohexyl ester, hydrochloride, (E)-
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Carbanilic acid, m-hexyloxy-, 2-piperidinocyclohexyl ester, hydrochloride, (E)- is a bioactive chemical. | |||
T33258 |
m-Dioxane, 5-isopropyl-5-(1-methoxyethyl)-2-methyl-, (E)-
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m-Dioxane, 5-isopropyl-5-(1-methoxyethyl)-2-methyl-, (E)- is a bioactive chemical. | |||
T27287 |
Estredox
E 2CDS,E-2-CDS,IDR 90104,E-2CDS,IDR-90104,E 2 CDS |
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Estredox, an estrogen receptor agonist, is used potentially for the treatment of vasomotor symptoms. | |||
T9539 | (E)-1,7,7-trimethyl-3-((3-(trifluoromethyl)phenyl)imino)bicyclo【2.2.1】heptan-2-one | ||
(E)-1,7,7-trimethyl-3-((3-(trifluoromethyl)phenyl)imino)bicyclo【2.2.1】heptan-2-one 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T9539。 | |||
T6070 |
(E/Z)-Rigosertib sodium
N-[2-甲氧基-5-[[[2-(2,4,6-三甲氧基苯基)乙烯基]磺酰]甲基]苯基]甘氨酸钠盐,(E/Z) ON-01910 sodium |
PLK | Cell Cycle/Checkpoint |
ON-01910 是一种非 ATP 竞争性 PLK1 抑制剂(IC50 为 9 nM,在无细胞试验中)。它对 Plk2 的选择性高出 30 倍,对 Plk3 没有活性。 Rigosertib 抑制 PI3K/Akt 通路并激活氧化应激信号。 Rigosertib 可诱导多种癌细胞凋亡。它是一种合成的苄基苯乙烯基砜类似物,具有潜在的抗肿瘤活性。 | |||
T13410 |
ZLDI-8
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Apoptosis; Phosphatase; Gamma-secretase; Immunology/Inflammation related | Apoptosis; Immunology/Inflammation; Metabolism; Neuroscience; Proteases/Proteasome; Stem Cells |
ZLDI-8 是 Notch 激活/裂解酶 ADAM-17 的抑制剂,可抑制 Notch 蛋白裂解,并降低促存活/抗凋亡和上皮-间质转化相关蛋白的表达。它还是竞争性不可逆酪氨酸磷酸酶抑制剂,以IC50为 5.32 μM 抑制 MHCC97-H 细胞的生长。 | |||
T80655 |
BVDU 5′-Triphosphate
BVdUTP,(E)-5-(2-Bromovinyl)-dUTP |
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
BVDU 5′-Triphosphate 是带有 5′-Triphosphate 标记、针对 DNA 聚合酶的抗病毒药物。它对水痘-带状疱疹病毒(VZV)和单纯疱疹病毒 1 型(HSV-1)具有高度选择性,这种选择性归因于病毒编码的胸苷激酶对其进行特异性磷酸化的能力。 | |||
T21900 |
ML-336
(E)-2-((1,4-二甲基哌嗪-2-亚基)氨基)-5-硝基-N-苯基苯甲酰胺 |
Others | Others |
ML-336 是一种喹唑啉酮类的委内瑞拉马脑炎病毒 (VEEV) 抑制剂,其VEEV TC-83 CPE(IC50:32 nM)、VEEV V3526 CPE(IC50:20 nM)、VEEV 野生型 CPE (IC50:42 nM),有效抑制 VEEV 诱导的三种病毒株 (V3526、TC-83和野生型) 细胞病变效应。 | |||
T66097 |
Ethyl 4-bromocrotonate
(E)-Ethyl 4-bromobut-2-enoate |
Antifungal | Microbiology/Virology |
Ethyl 4-bromocrotonate ((E)-Ethyl 4-bromobut-2-enoate) 是一种抗菌化合物,属于酯类。作为一种重要的医药中间体,它已被用作酶催化反应的底物,用作研究酶动力学的工具。此外,它也被发现具有抗炎和镇痛作用。 | |||
T38774 |
E67-2
E67-2 |
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E67-2, a derivative of E67, is a low-toxicity, selective inhibitor of the KIAA1718 Jumonji domain. It has an IC 50 value of 3.4 μM. E67-2 specifically inhibits the Jumonji demethylase for histone H3 lysine 9 (H3K9) and histone H3 lysine 4 (H3K4) demethylase. | |||
T35881 |
Resolvin E2
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Resolvin E2 (RvE2) is a member of the specialized pro-resolving mediator (SPM) family of bioactive lipids.1It is produced from eicosapentaenoic acidviaan 18-HEPE intermediate, which is formed by aspirin-acetylated COX-2-mediated oxidation of EPA, by 5-lipoxygenase (5-LO) in human polymorphonuclear (PMN) neutrophils.2,3RvE2 (20 ng/animal) inhibits increases in inflammatory exudate neutrophil infiltration in a mouse model of peritonitis induced by zymosan A .3Hepatic RvE2 levels are increased in m... | |||
T32720 |
Levuglandin E2
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Levuglandin E2 is a secoprostanoid from prostaglandin endoperoxide. | |||
T23429 |
KDM2/7-IN-1
TC-E 5002 |
Others | Others |
Selective histone demethylase KDM2/7 subfamily inhibitor |
Cat. No. | Product Name | Target | Signaling Pathways |
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TN2373 |
(E/Z)-Ginkgolic acid C17:2
Ginkgolic Acid C17:2 |
Dehydrogenase | Metabolism |
(E/Z)-Ginkgolic acid C17:2 (Ginkgolic Acid C17:2) 是一种可从银杏中提取的天然产物,可靶向人二氢乳清酸脱氢酶 (DHODH). | |||
T8052 |
(E)-2-Methyl-2-pentenoic acid
trans-2-Methyl-2-pentenoic Acid,反式-2-甲基-2-戊烯酸 |
Others | Others |
(E)-2-Methyl-2-pentenoic acid 可作为合成具有细胞毒性的天然产物 Lactimidomycin 的组分。 | |||
T5261 |
(E)-Oct-2-enoic acid
trans-2-Octenoic acid,2-Octenoate,2-辛烯酸,2-Octenoic acid |
Others; Endogenous Metabolite | Metabolism; Others |
(E)-Oct-2-enoic acid (2-Octenoate) 是内源性代谢产物的一种。 | |||
TN1159 |
(1(10)E,2R*,4R*)-2-Methoxy-8,12-epoxygermacra-1(10),7,11-trien-6-one
[(1(10)E,2R,4R)]-2-Methoxy-8,12-epoxygemacra-1(10),7,11-trien-6-one |
Others | Others |
(1(10)E,2R*,4R*)-2-Methoxy-8,12-epoxygermacra-1(10),7,11-trien-6-one ([(1(10)E,2R,4R)]-2-Methoxy-8,12-epoxygemacra-1(10),7,11-trien-6-one) 是一种来自姜黄的倍半萜。 | |||
TN7168 |
Farnesylacetone
(5E,9E)-6,10,14-Trimethylpentadeca-5,9,13-trien-2-one,法尼基丙酮,Farnesyl acetone,E,E-farnesylacetone |
Others | Others |
Farnesylacetone ((5E,9E)-6,10,14-Trimethylpentadeca-5,9,13-trien-2-one) 是一种海洋来源的天然产物,存在于Sargassum micracanthum。 | |||
TN5517 |
2''-O-E-p-Coumaroylafzelin
|
||
2''-O-E-p-Coumaroylafzelin 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN5517,CAS号为 151455-10-6。 | |||
TN2747 | 2-Acetoxy-3-deacetoxycaesaldekarin E | Antifection | Microbiology/Virology |
2-Acetoxy-3-deacetoxycaesaldekarin E shows significant dose-dependent inhibitory effects on Plasmodium falciparum FCR-3/A2 growth in vitro. | |||
T1048 |
Estradiol
雌二醇,E2,17β-Estradiol,17β-Oestradiol,β-Estradiol |
Estrogen Receptor/ERR; Estrogen/progestogen Receptor; Endogenous Metabolite | Endocrinology/Hormones; Metabolism |
Estradiol (E2) 是一种天然的类固醇性激素,对于女性生育能力和第二性征的维持至关重要。Estradiol 通过雌激素受体 β (ERβ) 上调 IL-6 表达。 | |||
T2S0850 |
Malic acid
E 296,苹果酸,2-Hydroxysuccinic acid,Hydroxybutanedioic acid,FDA 2018,Deoxytetraric acid,Pomalus acid |
Others; Endogenous Metabolite | Metabolism; Others |
Malic acid (Pomalus acid) 是一种天然存在于水果中的二羧酸,如苹果和梨。Malic acid 在许多酸味或酸味食物中起作用。 | |||
T5679 |
(E)-Ferulic acid
trans-Ferulic acid,反式阿魏酸,(E)-Coniferic acid |
BCL; Ferroptosis; Wnt/beta-catenin; Endogenous Metabolite | Apoptosis; Cytoskeletal Signaling; Metabolism; Stem Cells |
(E)-Ferulic acid ((E)-Coniferic acid) 是阿魏酸的异构体,阿魏酸是在植物细胞壁中丰富存在的芳香族天然产物。 它引起 β-catenin 的磷酸化,导致其蛋白酶体降解,增加促凋亡因子 Bax 的表达,降低促生存因子的表达。它在人肺癌细胞系 H1299 中发挥抗增殖和抗迁移作用。 | |||
T5014 |
Prostaglandin E2
地诺前列酮,前列腺素 E2,PGE2,Dinoprostone,Prostaglandin E2 (PGE2) |
Endogenous Metabolite; Prostaglandin Receptor | GPCR/G Protein; Immunology/Inflammation; Metabolism |
Prostaglandin E2 (PGE2) 是一种天然激素,参与人体内的各种生理过程,包括平滑肌收缩和放松、调节血管扩张和收缩、调节血压和炎症调节。 | |||
T5715 |
(E)-Flavokawain A
(E)-1-(2-羟基-4,6-二甲氧基苯基)-3-(4-甲氧基苯基)-2-丙烯-1-酮,FLAVOKAVAIN A(P),卡瓦胡椒素A |
Apoptosis; P450 | Apoptosis; Metabolism |
(E)-Flavokawain A 是一种来自卡瓦提取物的新型查尔酮,通过参与 Bax 蛋白依赖性和线粒体依赖性凋亡途径诱导膀胱癌细胞凋亡,并抑制小鼠肿瘤生长,具有抗癌作用。 | |||
TN2173 |
Salvianolic acid D
(R,E)-2-((3-(2-(carboxymethyl)-3,4-dihydroxyphenyl)acryloyl)oxy)-3-(3,4-dihydroxyphenyl)propanoic acid,丹酚酸D,丹酚酸 D |
Others | Others |
Salvianolic acid D ((R,E)-2-((3-(2-(carboxymethyl)-3,4-dihydroxyphenyl)acryloyl)oxy)-3-(3,4-dihydroxyphenyl)propanoic acid) 是一种分离自Salvia miltiorrhiza 中的化合物,有潜在抗血小板作用。 | |||
TN7139 |
(3E)-4-(1H-indol-3-yl)but-3-en-2-one
4-(1H-indol-3-yl)but-3-en-2-one,(E)-4-(1H-indol-3-yl)but-3-en-2-one |
Others | Others |
(3E)-4-(1H-indol-3-yl)but-3-en-2-one ((E)-4-(1H-indol-3-yl)but-3-en-2-one) 是一种海洋来源的天然产物,存在于Tedania (Tedania) ignis。 | |||
TN5922 |
3,4-Dimethoxycinnamyl alcohol
(E)-3-(3,4-dimethoxyphenyl)prop-2-en-1-ol,3,4-二甲氧基肉桂醇 |
Others | Others |
3,4-Dimethoxycinnamyl alcohol ((E)-3-(3,4-dimethoxyphenyl)prop-2-en-1-ol) 显示出显着的抗菌和细胞毒性活性。 | |||
TN2117 |
Pulsatilloside E
3-O-B-D-葡萄糖( 1→4)-[ A -L-鼠李糖(1→2)]- A-L-阿拉伯糖 23-羟基羽扇豆20(29)-烯-28–酸- 28-O-鼠李糖(1→4)葡萄糖(1→6)葡萄糖苷,Pulchinenoside E,白头翁皂苷E |
Others | Others |
Pulsatilloside E (Pulchinenoside E) 是一种从毛茛科白头翁Pulsatilla chinensis (Ranunculaceae)的根中分离出来的天然产物。 | |||
TN2711 | 2'',4''-Di-O-(E-p-coumaroyl)afzelin | Antifection | Microbiology/Virology |
Antimicrobial agent. | |||
TN2393 |
(R,E)-Deca-2-ene-4,6-diyne-1,8-diol
|
Others | Others |
(R,E)-Deca-2-ene-4,6-diyne-1,8-diol is a natural from Toricellia angulata | |||
T3250 |
Royal Jelly acid
10-羟基-2-癸烯酸(10-HAD),蜂王浆酸,王浆酸,10-Hydroxy-trans-2-decenoic acid,10-Hydroxy-2-decenoic acid,10H2DA,10-Hydroxy-2-decylenic acid,Queen Bee Acid,(E)-10-Hydroxy-2-decenoic acid |
VEGFR; Endogenous Metabolite | Angiogenesis; Metabolism; Tyrosine Kinase/Adaptors |
Royal Jelly acid (Queen Bee Acid) 是一种蜂王浆中的主要脂肪酸,可促进神经元的生长和保护,减少焦虑。 | |||
T7991 |
2-Hydroxycinnamic acid
邻羟基肉桂酸(邻香豆酸),(E)-3-(2-羟基苯基)丙烯酸 |
Others; SARS-CoV; HIV Protease | Microbiology/Virology; Others; Proteases/Proteasome |
2-Hydroxycinnamic acid 是从肉桂的甲醇提取物中分离出的一种天然产物,具有光氧化活性。它对HIV/SARS-CoV S 假病毒的感染具有抑制作用,IC50为 0.3 mM。 | |||
T5704 |
Entadamide-A-β-D-glucopyranoside
(E)-N-[2-(β-D-Glucopyranosyloxy)ethyl]-,榼藤子酰胺A-Β-D-吡喃葡萄糖苷,榼藤子酰胺A-β-D-吡喃葡萄糖 |
Others | Others |
Entadamide-A-β-D-glucopyranoside ((E)-N-[2-(β-D-Glucopyranosyloxy)ethyl]-) 是一种菜豆虫种子的主要成分,具有抗补体作用。 | |||
TN6304 |
Apigenin 4'-O-(2'',6''-di-O-E-p-coumaroyl)glucoside
|
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Apigenin 4'-O-(2'',6''-di-O-E-p-coumaroyl)glucoside 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN6304,CAS号为 71781-79-8。 | |||
TN6287 |
Apigenin 7-O-(2'',6''-di-O-E-p-coumaroyl)glucoside
Anisofolin B |
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Apigenin 7-O-(2'',6''-di-O-E-p-coumaroyl)glucoside 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN6287,CAS号为 1448779-19-8。 | |||
T4838 |
(S)-Malic acid
L-(-)-Malic acid,(S)-(-)-HYDROXYSUCCINIC ACID,(S)-2-Hydroxysuccinic acid,L-苹果酸 |
Others; Endogenous Metabolite | Metabolism; Others |
(S)-Malic acid ((S)-2-Hydroxysuccinic acid) 是天然存在的二羧酸,是水果酸甜味的来源,常用作食品添加剂。 | |||
T0937 |
Riboflavin
Vitamin B2,维生素B2,E101 |
Endogenous Metabolite | Metabolism |
Riboflavin (E101),一种人内源性代谢物, 是极易吸收的微量营养素。 | |||
TN4436 |
Licoricesaponin E2
|
Others | Others |
Licoricesaponin E2 displayed the inhibition on the growth of cancer cells with IC50 at 18.3-41.6 umol/L, it could significantly increase the cytotoxic activity after hydrolysis. | |||
TN1848 |
Kuwanon E
桑黄酮 E,桑皮酮 E,5'-[(E)-3,7-二甲基-2,6-辛二烯基]-2',4',5,7-四羟基黄烷酮 |
AChR | Neuroscience |
Kuwanon E inhibited cholinesterase enzyme in a dose-dependent manner with K i values ranging between 3.1 and 37.5 μM and between 1.7 and 19.1 μM against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes, respectively. Kuwanon E also inh | |||
TN5976 | Methyl lucidenate E2 | ||
Methyl lucidenate E2 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN5976,CAS号为 98665-12-4。 | |||
TN4862 |
Pulchinenoside E2
白头翁皂苷E2 |
Others | Others |
Pulchinenoside E2是一种天然产物,属于毛茛科白头翁属,其产品编号为 TN4862,CAS号为 244202-36-6。Pulchinenoside E2可用作对照参考。 | |||
T83349 |
3-O-(2'E,4'E-Decadienoyl)-ingenol
|
||
3-O-(2'E,4'E-Decadienoyl)-ingenol为天然二萜类化合物,对L-O2及GES-1人类正常细胞系表现出细胞毒性,其IC50值分别为8.22 μM与6.67 μM[1]。 | |||
TN1631 |
Eupalinolide K
[3AR-[3AR*,4R*(E),6E,9S*,10E,11AR*]]-4-羟基-2-甲基-2-丁烯酸 2,3,3A,4,5,8,9,11A-八氢-9-羟基-6,10-二甲基-3-亚甲基-2-氧代环癸五烯并[B]呋喃-4-基酯,野马追内酯 K,野马追内酯K |
STAT | JAK/STAT signaling; Stem Cells |
Eupalinolide K 是来自野马追的一种倍半萜内酯,是 STAT3抑制剂,可作为迈克尔反应受体。 | |||
T81991 |
Kaempferol-3-O-[2″,6″-di-O-E-p-coumaroyl]-β-D-glucopyranoside
|
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Kaempferol-3-O-[2″,6″-di-O-E-p-coumaroyl]-β-D-glucopyranoside为一种从O. dentata叶中提取的酰化坎氨酚葡萄糖苷,用作污染生物(蓝贻贝M. edulis)的驱虫剂。 | |||
T2S1625 |
(E)-Ethyl p-methoxycinnamate
Ethyl para-methoxycinnamate,Ethyl 4-methoxycinnamate,4-Methoxycinnamic Acid Ethyl Ester,对甲氧基肉桂酸乙酯,Ethyl methoxycinnamate,Ethyl p-methoxycinnamate,EPMC |
Others; COX | Immunology/Inflammation; Neuroscience; Others |
(E)-Ethyl p-methoxycinnamate (EPMC) 是从高良姜中提取的一种天然产物,具有抗炎、抗肿瘤和抗微生物作用。它在体外抑制COX-1和COX-2,IC50分别为 1.12 和 0.83 μM。 | |||
T2S0765 |
Epibetulinic acid
|
NO Synthase; Prostaglandin Receptor | GPCR/G Protein; Immunology/Inflammation |
Epibetulinic acid 对细菌内毒素刺激的小鼠巨噬细胞 (RAW 264.7) 中 NO 和前列腺素 E(2) 的产生具有有效的抑制作用,IC50分别为 0.7 和 0.6 μM,具有抗炎活性。 | |||
T4805 |
α-Pyridone
2-Hydroxypyridine,2-羟基吡啶 |
Others; Endogenous Metabolite | Metabolism; Others |
α-Pyridone (2-Hydroxypyridine) 是内源性代谢产物的一种。 | |||
T4S1422 |
Praeruptorin E
白花前胡素 E,白花前胡素E |
Others; Calcium Channel | Membrane transporter/Ion channel; Metabolism; Others |
Praeruptorin E 是白花前胡中的一种主要成分,是钙拮抗剂,pD2′值为 5.2。 | |||
T3733 |
(E)-Methyl 4-coumarate
Methyl trans-p-Coumarat,OMpCA,反式对羟基肉桂酸,Methyl 4-hydroxycinnamate |
Apoptosis; Others; Antibacterial | Apoptosis; Microbiology/Virology; Others |
(E)-Methyl 4-coumarate (OMpCA) 在几种植物中发现,如洋葱或海巴戟叶中。它与 Carnosic Acid 联用可诱导细胞凋亡,杀死急性髓性白血病细胞。它具有抗氧化和抗菌活性。 | |||
TN4379 |
Kansuinine A
|
IL Receptor; STAT; Interleukin | Immunology/Inflammation; JAK/STAT signaling; Stem Cells |
Kansuinine A 对IL-6 诱导的 Stat3激活有作用。Kansuinine A 显示出抗病毒和抗肿瘤活性。 | |||
TN1163 |
2'-Hydroxychalcone
|
Others | Others |
2'-Hydroxychalcone 是一种药物合成中间体,可用于合成黄酮类化合物。负载在纳米乳液中的2'-Hydroxychalcone 在Danio rerio 模型对副球孢子菌显示出杀真菌活性。2'-Hydroxychalcone 通过负载脂质的Hepg2细胞中的氧化应激诱导细胞毒性。2'-Hydroxychalcone 抑制通过逆转录聚合酶链反应确定的肿瘤坏死因子-α诱导ICAM-1,VCAM-1和E-选择素的稳态转录水平,因此可能会干扰其基因的转录。 | |||
T6S1487 |
Ginsenoside Rg5
人参皂苷Rg5,人参皂甙 Rg5 |
NF-κB; COX; IGF-1R | Immunology/Inflammation; Neuroscience; NF-κB; Tyrosine Kinase/Adaptors |
Ginsenoside Rg5 是红参的主要成分,可阻断IGF-1与其受体的结合,IC50约为90 nM。它还通过抑制NF-κB p65的 DNA 结合活性来抑制COX-2的 mRNA 表达。它可促进血管生成和改善高血压,具有抗炎和治疗阿尔茨海默病的潜力。 | |||
T5S2358 |
Dehydrocorydaline
Dehydrocorydalin,脱氢紫堇碱,13-Methylpalmatine |
BCL; PARP; p38 MAPK; Caspase; Parasite; Autophagy | Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; MAPK; Microbiology/Virology; Proteases/Proteasome |
Dehydrocorydaline (13-Methylpalmatine) 是一种生物碱。它调节Bax,Bcl-2蛋白表达,激活caspase-7,caspase-8,并使PARP 失活。它能增强p38 MAPK 活化,具有抗炎、抗癌等功效。它具有强大的抗疟疾作用,并具低细胞毒性。 | |||
T4010 |
Juglone
5-羟基对萘醌,5-Hydroxy-1,4-naphthoquinone,胡桃酮,Regianin |
DNA/RNA Synthesis; Antibacterial | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology |
Juglone (Regianin) 是一种从黑胡桃Juglans regia 中发现的黄色染料,有抗菌作用。 | |||
T36473 |
trans-Nerolidol
|
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trans-Nerolidol is a sesquiterpene that has been found in various plants, includingC. sativa, and has diverse biological activities, including antimicrobial, antioxidant, anticancer, and insecticidal properties.1,2,3,4In a disc assay,trans-nerolidol inhibits the growth ofS. aureus,B. subtilis,E. coli, andS. cerevisiaewith zones of inhibition measuring 10, 9, 10, and 4 mm, respectively.2It reduces viability of CaCo-2 adenocarcinoma cells with an IC50value of 28.7 mg/L and reduces production of re... | |||
T4S0350 |
Licochalcone B
甘草查尔酮 B,甘草查尔酮B |
Beta Amyloid; Others | Neuroscience; Others |
Licochalcone B 是从Glycyrrhiza inflate 根中提取的。它能够抑制淀粉样蛋白 β 自聚集作用 (IC50=2.16 μM) ,分解预先形成的 Aβ42原纤维,并通过螯合金属离子抑制金属诱导的 Aβ42聚集。 | |||
T6S1027 |
Tussilagone
|
Others | Others |
Tussilagone 是Tussilago farfara 的主要活性成分,具有抗炎作用。它抑制盲肠结扎和穿刺导致脓毒症的小鼠的炎症反应,提高其生存率。它改善葡聚糖硫酸钠诱导的小鼠结肠炎的炎症反应。 | |||
TN6032 | Alstoyunine E | ||
Alstoyunine E shows selective inhibition of Cox-2 (>75%). | |||
T75533 | Dihydromaniwamycin E | ||
Dihydromaniwamycin E 是一种热休克代谢物,对influenza 和SARS-CoV-2病毒具有抗病毒活性。 | |||
T75563 | Vanicoside E | ||
Vanicoside E 是一种抗氧化和抗癌剂。Vanicoside E 抑制L-Tyrosine 和L-DOPA,IC50为 45.23 μM 和 189.96 μM。 | |||
TN2558 |
1-O-Deacetylkhayanolide E
|
Others | Others |
1-O-Deacetylkhayanolide E是一种天然产物,属于楝科非洲楝属,其产品编号为 TN2558,CAS号为 1007387-95-2。1-O-Deacetylkhayanolide E可用作对照参考。 | |||
TN5994 | Elatoside E | ||
Elatoside E 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN5994,CAS号为 156980-30-2。 | |||
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