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98

抑制剂 & 化合物

46

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T36968	ARN-21934	Topoisomerase	DNA Damage/DNA Repair
	ARN-21934 是高选择性的人拓扑异构酶 II α 抑制剂，具有血脑屏障通透性。依托泊苷抑制 DNA 松弛的IC50为120 μM，ARN-21934 抑制 DNA 松弛的IC50为 2 μM。ARN-21934具有良好的体内药代动力学特性。
T5993	ARN-3236	AMPK; SIK	Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
	ARN-3236 是一种口服有活性的、具有选择性的盐诱导激酶2 (SIK2)抑制剂，它能够抑制SIK1 (IC50:21.63 nM)、SIK2(IC50<1 nM)和 SIK3(IC50:6.63 nM)。它具有抗肿瘤作用。
T5357	ARN272 ARN 272	FAAH	Metabolism; Neuroscience
	ARN272 是大麻素转运抑制剂的一种。
T2339	Apalutamide ARN-509	Androgen Receptor; GABA Receptor	Endocrinology/Hormones; Membrane transporter/Ion channel; Neuroscience
	Apalutamide (ARN-509) 是一种有效、竞争性的雄激素受体 (AR) 拮抗剂(IC50:16 nM)。
T25109	ARN-6039 ARN 6039,ARN6039
	ARN-6039 is an orally available inverse agonist of RORγ for Autoimmune Neuroinflammatory Demyelinating Disease. The activity of ARN-6039 against RORγ was demonstrated in a RORγ-activated IL-17A Prom/LUCPorter assay in HEK 293 cells (360 nM) and in IL-17 r
T9528	ARN19702	Others	Others
	ARN19702 是一种选择性，具有口服活性的，可逆的，可透过血脑屏障的 N-乙酰乙醇胺酸酰胺酶 (NAAA) 抑制剂，对人 NAAA 的 IC50为 230 nM。ARN19702 具有广泛的镇痛作用。
T21658	ARN14974	Others	Others
	ARN14974 是一种有效的全身活性的胞内酸性神经酰胺酶抑制剂 (IC50=79 nM)，是一种苯并恶唑酮甲酰胺化合物。
T5118	Brilanestrant GDC0810,GDC 0810,GDC-0810,ARN-810,RG 6046	Estrogen Receptor/ERR; Estrogen/progestogen Receptor	Endocrinology/Hormones
	Brilanestrant (GDC-0810) 是一种雌激素选择性降能器 (selective estrogen receptor degrader)(IC50:0.7 nM)，口服具有活性。
T7490	ARN2966	Beta Amyloid	Neuroscience
	ARN2966 是高效的，针对 APP 表达的转录后调节剂，能够抑制 APP 的表达从而使 Aβ的量降低。
T71554	ARN 14494
	ARN 14494 is a potent serine palmitoyltransferase inhibitor (SPT; IC50 = 27.3 nM). ARN 14494 inhibits synthesis of long chain ceramides and dihydroceramides in an in vitro model of Alzheimer's diease. The compound prevents the synthesis of proinflammatory cytokines and the oxidative stress-related enzymes iNOS and COX-2 in mouse primary cortical astrocytes. ARN 14494 is neuroprotective against β-amyloid 1-42 induced neurotoxicity in primary cortical neurons co-cultured with astrocytes.
T10370	ARN 077 URB913	Others	Others
	ARN 077 is a selective N-acylethanolamine acid amidase (NAAA) inhibitor (IC50: 7 nM for human NAAA). ARN 077 significantly increases palmitoyl ethanolamine (PEA) levels within the CNS.
T83950	ARN 11391
	ARN 11391是ITPR1 (Inositol 1,4,5-trisphosphate (IP3) receptor type 1)的增效剂，它直接作用于ITPR1，从而增强细胞内钙离子信号。ARN 11391还能增强表达突变型ITPR1细胞中的钙信号，这与SCA29型脊髓小脑共济失调有关。
T36969	ARN24139
	ARN24139 is a topoisomerase II poison (IC50= 7.3 μM in a topoisomerase II decatenation assay).1It inhibits proliferation of DU145, HeLa, and A549 cells (IC50s = 4.7, 3.8, and 3.1 μM, respectively). 1.Arencibia, J.M., Brindani, N., Franco-Ulloa, S., et al.Design, synthesis, dynamic docking, biochemical characterization, and in vivo pharmacokinetics studies of novel topoisomerase II poisons with promising antiproliferative activityJ. Med. Chem.63(7)3508-3521(2020)
T39859	ARN19689
	ARN19689 is an effective inhibitor of human NAAA, demonstrating high potency in the low nanomolar range (IC 50 = 0.042 μM). The compound acts through a non-covalent mechanism, highlighting its ability to interact with the enzyme for inhibition.
T36468	ARN14988
	ARN14988 is a potent inhibitor of acid ceramidase (IC50 = 12.8 nM for the human enzyme). It inhibits acid ceramidase activity and increases levels of C16 dihydro ceramide and C16 ceramide in A375, G361, M14, MeWo, MNT-1, and SK-MEL-28 melanoma cells. ARN14988 also reduces growth of A375 and G361 melanoma cells (EC50s = 41.8 and 67.7 μM, respectively).
T69606	ARN23746
	ARN23746 is a NKCC1 Inhibitor for the Treatment of Core Symptoms in Down Syndrome.
T71553	Ainsliadimer A
	Ainsliadimer A 是一种来自 Ainsliaea macrocephala 的倍半萜内酯二聚体，具有抗肿瘤活性，可诱导各种癌细胞的细胞死亡。
T61360	ARN25068	GSK-3; DYRK; Microtubule Associated; Src	Angiogenesis; Cell Cycle/Checkpoint; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Stem Cells; Tyrosine Kinase/Adaptors
	ARN25068是三种蛋白激酶(GSK-3β、FYN和DYRK1A)的亚微摩尔抑制剂，可用于治疗tau相关神经系统疾病。
T14321	ARN19874	Others	Others
	ARN19874 is a selective, reversible uncompetitive N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD) activity inhibitor. With an IC50 of ~34 μM[1].
T30137	ARN14686
	ARN14686 is an activity-based affinity probe for the detection of N-acylethanolamine acid amidase (NAAA) using click chemistry.
T60456	ARN726
	ARN726 是 N-酰基乙醇胺酸酰胺酶的有效抑制剂 (IC50 = 0.073 μM)，它以剂量依赖性方式降低饮酒动机。
T61883	ARN5187
	ARN5187 是一种亲溶酶体化合物，是 REV-ERBβ的配体。ARN5187抑制 REV-ERB 介导的转录调控和细胞自噬。ARN5187 显示出溶酶体效力和细胞毒性，可诱导细胞凋亡 (apoptosis)。
T61256	ARN1468
	ARN1468 (compound 5) is a highly effective orally active inhibitor of serpins. Inhibition of serpins activity by ARN1468 enables release of proteases, thereby reducing prion accumulation. ARN1468 demonstrates pronounced anti-prion effects in ScGT1 RML, ScGT1 22L, ScN2a RML, and ScN2a 22L cell lines, with EC 50 values of 8.64, 19.3, 11.2, and 6.27 μM [1].
T2318	Sacubitril/Valsartan Sacubitril mixture with Valsartan,沙库必曲/缬沙坦,Valsartan,Sacubitril,LCZ696	Apoptosis; RAAS; Neprilysin	Apoptosis; Endocrinology/Hormones; Metabolism
	Sacubitril/Valsartan (LCZ696)，以1:1摩尔比由Valsartan（一种ARB）和Sacubitril（AHU377）组成，为创新口服血管紧张素受体-脑啡肽酶（ARN）双重抑制剂，旨在治疗高血压与心力衰竭。其作用机制包括抑制炎症、氧化应激及细胞凋亡，有助于改善糖尿病心肌病。
T63476	ARN5187 trihydrochloride
	ARN5187 trihydrochloride 是一种亲溶酶体 REV-ERBβ 配体，对 REV-ERB 介导的转录调控和细胞自噬具有抑制作用。ARN5187 trihydrochloride 具有溶酶体效力和细胞毒性，能够诱导细胞凋亡 (apoptosis)。
T0220	Foscarnet sodium Phosphonoformate,膦甲酸钠	Virus Protease; Reverse Transcriptase; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Foscarnet sodium (Phosphonoformate) 是一种病毒 DNA 聚合酶活性抑制剂，可逆地抑制病毒复制。它是一种用于治疗巨细胞病毒性视网膜炎的抗病毒剂。
T21841	(±)-Hexanoylcarnitine chloride DL-Hexanoylcarnitine chloride	Others	Others
	(±)-Hexanoylcarnitine chloride 是一种脂肪酸代谢产物，能将脂肪酸分解成能够被身体利用的小分子化合物。(±)-Hexanoylcarnitine chloride 可通过大鼠骨骼肌毒性特异性从而作为一种生物标志物。
T6302	Lonafarnib Sarasar,氯那法尼,Sch66336	Raf; Transferase; Autophagy; Ras	Autophagy; GPCR/G Protein; MAPK; Metabolism
	Lonafarnib (Sch66336) 是一种可口服的 FPTase 抑制剂，作用于 H-ras、K-ras 和 N-ras，IC50分别为 1.9 nM、5.2 nM 和 2.8 nM。它具有抗肝炎三角洲病毒的活性。
T5856	Barnidipine hydrochloride 盐酸巴尼地平,YM-09730-5 hydrochloride,Mepirodipine (hydrochloride)	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Barnidipine hydrochloride (YM-09730-5 hydrochloride) 是一种二氢吡啶类钙通道阻滞剂，对 CaA 受体具有选择性作用。它是一种抗高血压药物，通过减少其血管扩张作用继发的外周血管阻力起作用。
T1182	Levocarnitine propionate hydrochloride Propionyl-L-carnitine hydrochloride,L-Propionylcarnitine chloride,丙酰左旋肉碱盐酸盐,ST-261,丙酰肉碱盐酸盐	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Levocarnitine propionate hydrochloride (ST-261) 可用于肾功能恶化，充血性心脏衰竭，间歇性跛行等疾病的研究。
T7099	Gefarnate	Others	Others
	Gefarnate 是一种胃炎和胃溃疡的研究药物，目前也用于研究干眼症。
T6271	Tipifarnib 替吡法尼,R115777,Zarnestra,IND 58359	Transferase	Metabolism
	Tipifarnib (IND 58359) 能够抑制法尼基转移酶 (FTase)，IC50=0.86 nM，具有潜在抗肿瘤特性。
T68079	Gedocarnil ZK 113315,SH 530	Others	Others
	Gedocarnil（ZK 113315）可用于研究中枢神经系统疾病。
T20535	Carnidazole ME 108,NSC293873,NSC 293873,ME-108,NSC-293873,ME108	Antibiotic; Parasite	Microbiology/Virology
	Carnidazole (ME-108) 具有抗原生动物活性，可用于治疗滴虫感染的研究。
T22484	(±)-Propionylcarnitine chloride Propionyl-DL-carnitine chloride	Endogenous Metabolite	Metabolism
	(±)-Propionylcarnitine chloride (Propionyl-DL-carnitine chloride) 是一种短链酰基肉碱的混合物，可用作膳食补充剂，可用于研究慢性糖尿病。
T17102	Tipifarnib (S enantiomer) Tipifarnib S enantiomer,(S)-(-)-R-115777,(S)-Tipifarnib,IND-58359 S enantiomer	Transferase	Metabolism
	Tipifarnib S enantiomer ((S)-(-)-R-115777) 是Tipifarnib 的 S 型对映体，它比 Tipifarnib 特性低。其中 Tipifarnib 是farnesyltransferase 高效特异性抑制剂，IC50=0.6 nM。
T37735	Stearoyl-L-carnitine chloride C18 Carnitine,Stearoylcarnitine chloride
	Stearoyl-L-carnitine chloride（Acylcarnitine C18:0）是一种存在于小脑中的长链酰基肉碱，抑制 GlyT2 ，是研究脂代谢的重要组成部分。
T37359	Myristoyl-L-carnitine chloride L-Myristoylcarnitine chloride	Endogenous Metabolite	Metabolism
	Myristoyl-L-carnitine chloride (L-Myristoylcarnitine chloride) 是人体的代谢物之一，与遗传代谢疾病有关。Tetradecanoylcarnitine 是研究糖尿病和自身免疫性肝炎的潜在标记物。
T7550	Barnidipine YM-09730-5(Free base),(4S)-2,6-二甲基-4-(间硝基苯基)-1,4-二氢吡啶-3,5-二羧酸 (3S)-1-苄基-3-吡咯烷基-甲基酯,Mepirodipine	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Barnidipine (YM-09730-5(Free base)) 是一种二氢吡啶类钙通道阻滞剂，对 CaA 受体具有选择性作用。它是一种抗高血压药物，通过减少其血管扩张作用继发的外周血管阻力起作用。
T38253	Lauroyl-L-carnitine (chloride) Lauroyl-L-carnitine Hydrochloride
	Lauroyl-L-carnitine (chloride) (Lauroyl-L-carnitine Hydrochloride)是一种酰基肉碱和表面活性剂，已被用于渗透猪肠细胞，以输送极性荧光探针荧光黄。
T26551	Acetyl-L-carnitine RO 447190,L-Acetylcarnitine,LAC,L-O-Acetylcarnitine,ALCAR,Acetyl L carnitine	Endogenous Metabolite	Metabolism
	Acetyl-L-carnitine(RO 447190) 是一种可透过血脑屏障的氨基酸左旋肉碱，常作为膳食补充剂，对神经炎症有益。Acetyl-L-carnitine 具有神经保护作用，可用以研究像阿尔茨海默病类的神经疾病。
TP1088	N-Acetylcarnosine N-Acetyl-L-carnosine,N-乙酰肌肽	Others	Others
	N-Acetylcarnosine (N-Acetyl-L-carnosine) 是一种含有组氨酸的天然二肽，是药理学上主要的 L-carnosine 的来源。它是一种眼科药物，对人类白内障具有潜在的应用价值。
T12356	Palmitoylcarnitine Palmitoyl DL-carnitine	Endogenous Metabolite	Metabolism
	Palmitoylcarnitine (Palmitoyl DL-carnitine) 是一种线粒体脂肪酸氧化中间体，可作为表面活性剂。
T13810	Palmitoylcarnitine chloride Palmitoyl DL-carnitine chloride	PKC	Chromatin/Epigenetic; Cytoskeletal Signaling
	Palmitoylcarnitine chloride (Palmitoyl DL-carnitine chloride) 是一种线粒体脂肪酸氧化中间体，可介导脂质内心脏保护。Palmitoylcarnitine chloride 通过消耗谷胱甘肽来消除结直肠癌细胞的存活，诱导癌细胞死亡，调节蛋白激酶 C βII 与其受体 RACK1 之间的相互作用。
T32098L	Homocarnosine acetate	GABA Receptor; Endogenous Metabolite	Membrane transporter/Ion channel; Metabolism; Neuroscience
	Homocarnosine acetate 是大脑特有的二肽，由 γ-氨基丁酸 (GABA) 和组氨酸组成。它具有抗氧化和抗炎作用、预防 DNA 损伤和抑制晚期糖基化终产物形成
T7882	Indomethacin farnesil 吲哚美辛法呢酯,Infree	Others; COX; Autophagy	Autophagy; Immunology/Inflammation; Neuroscience; Others
	Indomethacin farnesil (Infree) 是具有口服活性的 Indomethacin 前药，可通过干扰溶酶体的正常功能来破坏自噬流，有抗炎和抗风湿作用。它是一种可透过血脑屏障的，非选择性的 COX1和 COX2抑制剂，在 CHO 细胞中，对人 COX-1 和 COX-2 的IC50值分别为 18 nM 和 26 nM。
T73766	Isobutyryl-L-carnitine chloride
	Isobutyryl-L-carnitine chloride 是酰基辅酶 A 脱氢酶的产物。
T10684L	Carnostatine hydrochloride SAN9812 hydrochloride	Others	Others
	Carnostatine hydrochloride (SAN9812 hydrochloride) 是一种有效的选择性肌肽酶 1 (CN1) 抑制剂，对人重组 CN1 的Ki 值为 11 nM。Carnostatine hydrochloride 可用于治疗糖尿病性肾病 (DN) 。
T73752	Glutarylcarnitine lithium
	Glutarylcarnitine lithium 丙二酸尿症和 I 型戊二酸尿症的重要诊断代谢物。
T78081	Farnesyl Pyrophosphate ammonium Farnesyl diphosphate ammonium
	Farnesyl pyrophosphate ammonium salt为15碳类异戊二烯代谢中间体，源自MVA途径，兼具TRPM2激动剂功能，能够触发TRPM2通道开放并促进离子流入细胞。它亦是胆固醇合成、泛醌合成、蛋白质法尼基化修饰以及GGPP合成的关键底物。

化合物

Cat.No: T36968

Target: Topoisomerase

Cat.No: T5993

Target: AMPK, SIK

Cat.No: T5357

Synonym: ARN 272

Target: FAAH

Cat.No: T2339

Synonym: ARN-509

Target: Androgen Receptor, GABA Receptor

Cat.No: T25109

Synonym: ARN 6039,ARN6039

Cat.No: T9528

Target: Others

Cat.No: T21658

Target: Others

Cat.No: T5118

Synonym: GDC0810,GDC 0810,GDC-0810,ARN-810,RG 6046

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor

Cat.No: T7490

Target: Beta Amyloid

Cat.No: T71554

Cat.No: T10370

Synonym: URB913

Target: Others

Cat.No: T83950

Cat.No: T36969

Cat.No: T39859

Cat.No: T36468

Cat.No: T69606

Cat.No: T71553

Cat.No: T61360

Target: GSK-3, DYRK, Microtubule Associated, Src

Cat.No: T14321

Target: Others

Cat.No: T30137

Cat.No: T60456

Cat.No: T61883

Cat.No: T61256

Sacubitril/Valsartan

Cat.No: T2318

Synonym: Sacubitril mixture with Valsartan,沙库必曲/缬沙坦,Valsartan,Sacubitril,LCZ696

Target: Apoptosis, RAAS, Neprilysin

ARN5187 trihydrochloride

Cat.No: T63476

Foscarnet sodium

Cat.No: T0220

Synonym: Phosphonoformate,膦甲酸钠

Target: Virus Protease, Reverse Transcriptase, DNA/RNA Synthesis

(±)-Hexanoylcarnitine chloride

Cat.No: T21841

Synonym: DL-Hexanoylcarnitine chloride

Target: Others

Cat.No: T6302

Synonym: Sarasar,氯那法尼,Sch66336

Target: Raf, Transferase, Autophagy, Ras

Barnidipine hydrochloride

Cat.No: T5856

Synonym: 盐酸巴尼地平,YM-09730-5 hydrochloride,Mepirodipine (hydrochloride)

Target: Calcium Channel

Levocarnitine propionate hydrochloride

Cat.No: T1182

Synonym: Propionyl-L-carnitine hydrochloride,L-Propionylcarnitine chloride,丙酰左旋肉碱盐酸盐,ST-261,丙酰肉碱盐酸盐

Target: Histamine Receptor

Cat.No: T7099

Target: Others

Cat.No: T6271

Synonym: 替吡法尼,R115777,Zarnestra,IND 58359

Target: Transferase

Cat.No: T68079

Synonym: ZK 113315,SH 530

Target: Others

Cat.No: T20535

Synonym: ME 108,NSC293873,NSC 293873,ME-108,NSC-293873,ME108

Target: Antibiotic, Parasite

(±)-Propionylcarnitine chloride

Cat.No: T22484

Synonym: Propionyl-DL-carnitine chloride

Target: Endogenous Metabolite

Tipifarnib (S enantiomer)

Cat.No: T17102

Synonym: Tipifarnib S enantiomer,(S)-(-)-R-115777,(S)-Tipifarnib,IND-58359 S enantiomer

Target: Transferase

Stearoyl-L-carnitine chloride

Cat.No: T37735

Synonym: C18 Carnitine,Stearoylcarnitine chloride

Myristoyl-L-carnitine chloride

Cat.No: T37359

Synonym: L-Myristoylcarnitine chloride

Target: Endogenous Metabolite

Cat.No: T7550

Synonym: YM-09730-5(Free base),(4S)-2,6-二甲基-4-(间硝基苯基)-1,4-二氢吡啶-3,5-二羧酸 (3S)-1-苄基-3-吡咯烷基-甲基酯,Mepirodipine

Target: Calcium Channel

Lauroyl-L-carnitine (chloride)

Cat.No: T38253

Synonym: Lauroyl-L-carnitine Hydrochloride

Acetyl-L-carnitine

Cat.No: T26551

Synonym: RO 447190,L-Acetylcarnitine,LAC,L-O-Acetylcarnitine,ALCAR,Acetyl L carnitine

Target: Endogenous Metabolite

N-Acetylcarnosine

Cat.No: TP1088

Synonym: N-Acetyl-L-carnosine,N-乙酰肌肽

Target: Others

Palmitoylcarnitine

Cat.No: T12356

Synonym: Palmitoyl DL-carnitine

Target: Endogenous Metabolite

Palmitoylcarnitine chloride

Cat.No: T13810

Synonym: Palmitoyl DL-carnitine chloride

Target: PKC

Homocarnosine acetate

Cat.No: T32098L

Target: GABA Receptor, Endogenous Metabolite

Indomethacin farnesil

Cat.No: T7882

Synonym: 吲哚美辛法呢酯,Infree

Target: Others, COX, Autophagy

Isobutyryl-L-carnitine chloride

Cat.No: T73766

Carnostatine hydrochloride

Cat.No: T10684L

Synonym: SAN9812 hydrochloride

Target: Others

Glutarylcarnitine lithium

Cat.No: T73752

Farnesyl Pyrophosphate ammonium

Cat.No: T78081

Synonym: Farnesyl diphosphate ammonium

Cat. No.	Product Name	Target	Signaling Pathways
TN7168	Farnesylacetone (5E,9E)-6,10,14-Trimethylpentadeca-5,9,13-trien-2-one,法尼基丙酮,Farnesyl acetone,E,E-farnesylacetone	Others	Others
	Farnesylacetone ((5E,9E)-6,10,14-Trimethylpentadeca-5,9,13-trien-2-one) 是一种海洋来源的天然产物，存在于Sargassum micracanthum。
T9352	hydrocotarnine	Others	Others
	hydrocotarnine 是 Cbl 的抑制剂。
T0743	DL-Carnitine Carnitina,Carnitine,卡尼丁	Others	Others
	DL-Carnitine (Carnitina) 是肝脏和横纹肌的成分。在治疗上它用于刺激胰腺和胃的分泌并治疗高脂蛋白血症。
T19564	Stearoylcarnitine Stearoyl-L-carnitine	Endogenous Metabolite	Metabolism
	Stearoylcarnitine (Stearoyl-L-carnitine) 是一种脂肪酯脂质分子，是一种人内源代谢产物，可作为早发型子痫前期和晚发性子痫前期的生物标志物。
TN6835	(E)-β-Farnesene (6E)-7,11-dimethyl-3-methylidenedodeca-1,6,10-triene,trans-β-Farnesene	Antifungal	Microbiology/Virology
	(E)-β-Farnesene (trans-β-Farnesene) 是一种存在于 Phlomis aurea Decne中的倍半萜烃，是许多蚜虫报警信息素的主要成分，可中断蚜虫摄食。(E)-β-Farnesene 通过破坏昆虫激素平衡来损害 Chilo suppressalis 幼虫的发育和存活。
T8249	Hexahydrofarnesyl acetone 植酮,Phytone	Others; Antibacterial	Microbiology/Virology; Others
	Hexahydrofarnesyl acetone (Phytone) 是从Launaea mucronata 中分离得到的倍半萜，具有抗菌和抗炎活性，可研究缓解疼痛。
T2203	D-Carnitine hydrochloride (S)-Carnitine Hydrochloride,L-Carnitine hydrochloride	Others; Endogenous Metabolite	Metabolism; Others
	D-Carnitine hydrochloride ((S)-Carnitine Hydrochloride) 已被用于研究麦角硫因素转运蛋白 SLC22A4 和肉毒碱转运蛋白 SLC22A5，也被用于使棕榈酸进入线粒体。
T19340	Glutarylcarnitine O-glutaroyl-L-carnitine	Endogenous Metabolite	Metabolism
	Glutarylcarnitine (O-glutaroyl-L-carnitine) 是大多数串联质谱新生儿筛查计划中监测的丙二酸尿症和谷草酸尿症 I 型的诊断代谢物。
T12295	Oleoylcarnitine Oleoyl-L-carnitine	Endogenous Metabolite	Metabolism
	Oleoylcarnitine (Oleoyl-L-carnitine) 抑制腺嘌呤核苷酸转位酶（AdNT）活性，ic50为14 μM。Oleoylcarnitine 是检测神经分裂的重要指标。
T13280	Valerylcarnitine VALERYL-L-CARNITINE	Endogenous Metabolite	Metabolism
	Valerylcarnitine (VALERYL-L-CARNITINE) 是一种短链脂肪酸，可用于研究 2 型糖尿病。
T2563	Acetyl-L-carnitine hydrochloride Acetyl L-carnitine hydrochloride,O-Acetylcarnitine,乙酰-L-肉(毒)碱盐酸盐,O-acetyl-L-carnitine,O-Acetyl-L-carnitine hydrochloride	Others; Endogenous Metabolite	Metabolism; Others
	Acetyl-L-carnitine hydrochloride (Acetyl L-carnitine hydrochloride) 是一种由内源性左旋肉碱的乙酰化形式的盐酸盐组成的营养补充剂，具有潜在的神经保护、认知增强、抗抑郁和免疫调节活性。还可缓解化疗、糖尿病或其他疾病引起的周围神经病变。此外，乙酰左旋肉碱可能通过增加T淋巴细胞成熟来调节免疫反应，并可能下调促炎细胞因子对病毒(如SARS-CoV-2)的反应。它还可能破坏ACE2信号通路并抑制活性氧(ROS)的产生。
T6475	(±)-Carnitine chloride Monocamin,DL-Carnitine HCl,Bicarnesine,混旋肉碱盐酸盐,DL-Carnitine chloride	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	(±)-Carnitine chloride (Monocamin) 有D 和L 两种异构体。其中 L-carnitine 在脂肪酸的 β-氧化中起重要作用，也具有抗氧化作用和抗炎活性。
T4957	Carnosic acid	Apoptosis; ROS; Antibacterial	Apoptosis; Immunology/Inflammation; Microbiology/Virology
	Carnosic acid 抑制细胞增殖，有抗菌、抗炎和抗氧化应激作用。
T19581	Tiglyl carnitine	Endogenous Metabolite	Metabolism
	Tiglyl carnitine 与肺癌和肉碱和甘氨酸对3-酮硫解酶缺乏症有关。
T19384	Isovalerylcarnitine	Apoptosis; Cysteine Protease	Apoptosis; Proteases/Proteasome
	Isovalerylcarnitine (3-methylbutyrylcarnitine) 是 L-亮氨酸分解代谢和异戊酸的积累产生的小分子化合物，也是一种具有选择性和有效性的钙蛋白酶 (calpain) 激活剂，可促使细胞凋亡，与异戊酸血症有关，可作为异戊酸血症的标志。
T12014	Methyl carnosate	Others	Others
	Methyl camosate, a diterpene sourced from Salvia officinalis or Rosmarinus officinalis, exhibits pronounced antioxidant and antibacterial properties.
TN1405	Arnicolide D 山金车内酯 D,山金车内酯D	Akt; Caspase; PI3K; STAT; mTOR	Apoptosis; Cytoskeletal Signaling; JAK/STAT signaling; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Stem Cells
	Arnicolide D 是从石胡荽中分离出的一种倍半萜内酯，以浓度和时间依赖性方式抑制鼻咽癌细胞活力。它调节细胞周期，激活 caspase 信号通路并抑制 PI3K/AKT/mTOR 和 STAT3 信号通路。
T19398	L-Octanoylcarnitine	Endogenous Metabolite	Metabolism
	L-Octanoylcarnitine 是存在于血浆中的活性辛酰肉碱，是一种乳腺癌的潜在生物标志物。
TN1111	Arnidiol	Immunology/Inflammation related	Immunology/Inflammation
	Arnidiol 是一种五环三萜烯，从Barleria Longiflora LinnF. 中提取得到。
T0846	L-Carnitine L(-)-Carnitine,Levocarnitine,左旋肉碱	Endogenous Metabolite; Fatty Acid Synthase	Metabolism
	L-Carnitine (L(-)-Carnitine) 是一种人内源性分子，在人体内以蛋氨酸和赖氨酸为底物进行生物合成，并参与脂肪酸代谢。L-Carnitine 将长链脂肪酰辅酶A 转运到线粒体。L-Carnitine 能够改善许多先天性代谢错误的代谢失衡。
T8028	Farnesyl acetate Farnesyl Acetate (mixture of isomers),3,7,11-三甲基-2,6,10-十二烷三烯-1-醇乙酸酯,乙酸法呢醇酯	Others	Others
	Farnesyl acetate (Farnesyl Acetate(mixture of isomers)) 是一种倍半萜，分离自 Amomum gagnepainii 中。它对红棕榈象虫幼虫有显著的毒性(LD50:7867 ppm)。
T4732	L-Carnosine Karnozin,L-肌肽,beta-Alanyl-L-histidine	Antioxidant; Endogenous Metabolite	Metabolism; oxidation-reduction
	L-Carnosine (Karnozin) 是由beta-丙氨酸和组氨酸组成的二肽，具有抑制衰老的作用。
T15157	Dodecanoylcarnitine Lauroylcarnitine	Endogenous Metabolite	Metabolism
	Dodecanoylcarnitine（(-)-Lauroylcarnitine）和脂肪酸氧化紊乱有关，使用 Dodecanoylcarnitine 可使鲑鱼降钙素的通透性增加。
T14840	Butyrylcarnitine	Endogenous Metabolite	Metabolism
	Butyrylcarnitine 是血浆中的代谢物，是疾病引起异常代谢的指标，可用于诊断心力衰竭和胰腺囊肿。
TN7254	(E,E)-Farnesol (2E,6E)-Farnesol	Others	Others
	(E,E)-Farnesol ((2E,6E)-Farnesol) 是一种由细菌、原生动物、真菌、植物和动物产生的倍半萜无环醇。(E,E)-Farnesol 可促进血管扩张。
T17048	Tetradecanoylcarnitine L-Myristoylcarnitine,Myristoyl-L-(-)-carnitine	Endogenous Metabolite	Metabolism
	Tetradecanoylcarnitine (L-Myristoylcarnitine) 是一种酰基肉碱，参与长链脂肪酸的β-氧化,是极长链酰辅酶A脱氢酶缺乏症的一种潜在标记物。
T6S1302	Carnosol	Nrf2; Endogenous Metabolite; S6 Kinase	Immunology/Inflammation; MAPK; Metabolism; PI3K/Akt/mTOR signaling
	Carnosol 是 Nrf2激活剂，增加 Nrf2 的水平以及能促进血红素氧合酶 1（HMOX1）表达。它是核糖体 S6激酶(RSK2)抑制剂，可用于胃癌相关研究，IC50值约为 5.5 μM。
TN2601	12-O-Methylcarnosic acid	Reductase	Endocrinology/Hormones; Metabolism
	12-O-Methylcarnosic acid 是分离自小叶丹参的丙酮提取物的一种二萜肉桂酸，可抑制 5α-还原酶 (5α-reductase) 活性，IC50为 61.7 μM。它抑制 LNCaP 细胞的增殖。它具有抗微生物活性、抗氧化和抗癌活性。
T4586	(Rac)-Arnebin 1 β,β-二甲基丙烯酰阿卡宁,beta, beta-dimethylacrylshikonin	Others	Others
	(Rac)-Arnebin 1 (beta, beta-dimethylacrylshikonin) 具有抗肿瘤作用，是β,β-Dimethylacrylalkannin 和 β,β-Dimethylacrylshikonin 的消旋体。β,β-Dimethylacrylalkannin 和 β,β-Dimethylacrylshikonin 是分离自紫草属植物中的萘醌类化合物。
T7868	Farnesol 法呢醇,里哪醇	Endogenous Metabolite; Antibacterial; Antibiotic	Metabolism; Microbiology/Virology
	Farnesol 是一种半萜醇，能够调节细胞间的通讯，有抑菌活性。
TN5828	(2Z,6Z,10E,14E,18E)-Farnesylfarnesol
	(2Z,6Z,10E,14E,18E)-Farnesylfarnesol 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN5828，CAS号为 90695-03-7。
TN2798	20-Deoxocarnosol	ROS; Antifection	Immunology/Inflammation; Microbiology/Virology
	20-Deoxocarnosol has antioxidant activity of measuring the decay of the radical cation diphenyl-picrylhydrazyl (DPPH).It also exhibits non-specific antiprotozoal activity due to high cytotoxicity.
T19391	L-Hexanoylcarnitine	Others	Others
	L-Hexanoylcarnitine is found to be associated with celiac disease, is an acylcarnitine.
TMA0716	Mearnsitrin	Others	Others
	Mearnsitrin是一种天然产物，属于芸香科黄皮属，其产品编号为 TMA0716，CAS号为 30484-88-9。Mearnsitrin可用作对照参考。
T20123	L-Carnitine hydrochloride L-Carnitine chloride,LC 80,Levocarnitine chloride,(R)-Carnitine hydrochloride,LC-80,LC80
	Carnitine is a quaternary amine that occurs naturally in most mammalian tissue. Carnitine is present in relatively high concentrations in skeletal muscle and heart where it is involved in regulating energy metabolism. It has also been used to allow the en
T19381	Isobutyryl-L-carnitine	5-HT Receptor	GPCR/G Protein; Neuroscience
	Isobutyryl-L-carnitine is a member of the class of compounds known as acylcarnitines. Isobutyryl-L-carnitine is a product of the acyl-CoA dehydrogenases.
T73764	L-Palmitoylcarnitine TFA
	L-Palmitoylcarnitine TFA 是一种长链酰基肉碱和脂肪酸代谢产物，在缺血期间积聚于肌膜并扰乱膜脂环境。L-Palmitoylcarnitine TFA 通过与Kir6.2的相互作用抑制KATP 通道活性，而不影响单通道电导。
T75458	(-)-10,11-Dihydroxyfarnesol
	(-)-10,11-Dihydroxyfarnesol 是一种从 Cryptomarasmius aucubae 内生真菌中分离出来的化合物，该化合物显着抑制一氧化氮(NO)的产生。
T3837	Mearnsetin	Antioxidant	oxidation-reduction
	Mearnsetin 具有抗氧化活性。
T40582	α-Farnesene
	α-Farnesene, a sesquiterpene, is a herbivore-induced plant volatile (HIPV) that plays a significant role in insect resistance across various plant species.
TN1404	ArnicolideC 山金车内酯C,山金车内酯 C,Arnicolide C	Others	Others
	Arnicolide C exhibits significant antiallergy activity.
T27304	Farnesiferol C Farnesiferol-C
	Farnesiferol C induces apoptosis via regulation of L11 and c-Myc.
T82966	Arnocoumarin
	Arnocoumarin为自X. arnottianum MAXIM分离出的天然化合物。
T75441	(8′α,9′β-Dihydroxy)-3-farnesylindole
	(8'α,9'β-Dihydroxy)-3-farnesylindole 对枯草芽孢杆菌具有较强的抑制活性（EC509.8μM）。
TN4237	Hydrocotarnine hydrobromide	Others	Others
	Hydrocotarnine hydrobromide 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN4237，CAS号为 5985-00-2。
TN7122	Micromarin F E-Methylarnottinin,5'-hydroxylosthole	Others	Others
	Micromarin F (E-Methylarnottinin) 是从 Micromelum minutum Wight et Arn 的茎中提取的香豆素衍生物。

天然产物

Farnesylacetone

Cat.No: TN7168

Synonym: (5E,9E)-6,10,14-Trimethylpentadeca-5,9,13-trien-2-one,法尼基丙酮,Farnesyl acetone,E,E-farnesylacetone

Target: Others

Cat.No: T9352

Target: Others

Cat.No: T0743

Synonym: Carnitina,Carnitine,卡尼丁

Target: Others

Stearoylcarnitine

Cat.No: T19564

Synonym: Stearoyl-L-carnitine

Target: Endogenous Metabolite

(E)-β-Farnesene

Cat.No: TN6835

Synonym: (6E)-7,11-dimethyl-3-methylidenedodeca-1,6,10-triene,trans-β-Farnesene

Target: Antifungal

Hexahydrofarnesyl acetone

Cat.No: T8249

Synonym: 植酮,Phytone

Target: Others, Antibacterial

D-Carnitine hydrochloride

Cat.No: T2203

Synonym: (S)-Carnitine Hydrochloride,L-Carnitine hydrochloride

Target: Others, Endogenous Metabolite

Glutarylcarnitine

Cat.No: T19340

Synonym: O-glutaroyl-L-carnitine

Target: Endogenous Metabolite

Oleoylcarnitine

Cat.No: T12295

Synonym: Oleoyl-L-carnitine

Target: Endogenous Metabolite

Valerylcarnitine

Cat.No: T13280

Synonym: VALERYL-L-CARNITINE

Target: Endogenous Metabolite

Acetyl-L-carnitine hydrochloride

Cat.No: T2563

Synonym: Acetyl L-carnitine hydrochloride,O-Acetylcarnitine,乙酰-L-肉(毒)碱盐酸盐,O-acetyl-L-carnitine,O-Acetyl-L-carnitine hydrochloride

Target: Others, Endogenous Metabolite

(±)-Carnitine chloride

Cat.No: T6475

Synonym: Monocamin,DL-Carnitine HCl,Bicarnesine,混旋肉碱盐酸盐,DL-Carnitine chloride

Target: Reactive Oxygen Species

Cat.No: T4957

Target: Apoptosis, ROS, Antibacterial

Tiglyl carnitine

Cat.No: T19581

Target: Endogenous Metabolite

Isovalerylcarnitine

Cat.No: T19384

Target: Apoptosis, Cysteine Protease

Methyl carnosate

Cat.No: T12014

Target: Others

Cat.No: TN1405

Synonym: 山金车内酯 D,山金车内酯D

Target: Akt, Caspase, PI3K, STAT, mTOR

L-Octanoylcarnitine

Cat.No: T19398

Target: Endogenous Metabolite

Cat.No: TN1111

Target: Immunology/Inflammation related

Cat.No: T0846

Synonym: L(-)-Carnitine,Levocarnitine,左旋肉碱

Target: Endogenous Metabolite, Fatty Acid Synthase

Farnesyl acetate

Cat.No: T8028

Synonym: Farnesyl Acetate (mixture of isomers),3,7,11-三甲基-2,6,10-十二烷三烯-1-醇乙酸酯,乙酸法呢醇酯

Target: Others

Cat.No: T4732

Synonym: Karnozin,L-肌肽,beta-Alanyl-L-histidine

Target: Antioxidant, Endogenous Metabolite

Dodecanoylcarnitine

Cat.No: T15157

Synonym: Lauroylcarnitine

Target: Endogenous Metabolite

Butyrylcarnitine

Cat.No: T14840

Target: Endogenous Metabolite

Cat.No: TN7254

Synonym: (2E,6E)-Farnesol

Target: Others

Tetradecanoylcarnitine

Cat.No: T17048

Synonym: L-Myristoylcarnitine,Myristoyl-L-(-)-carnitine

Target: Endogenous Metabolite

Cat.No: T6S1302

Target: Nrf2, Endogenous Metabolite, S6 Kinase

12-O-Methylcarnosic acid

Cat.No: TN2601

Target: Reductase

(Rac)-Arnebin 1

Cat.No: T4586

Synonym: β,β-二甲基丙烯酰阿卡宁,beta, beta-dimethylacrylshikonin

Target: Others

Cat.No: T7868

Synonym: 法呢醇,里哪醇

Target: Endogenous Metabolite, Antibacterial, Antibiotic

(2Z,6Z,10E,14E,18E)-Farnesylfarnesol

Cat.No: TN5828

20-Deoxocarnosol

Cat.No: TN2798

Target: ROS, Antifection

L-Hexanoylcarnitine

Cat.No: T19391

Target: Others

Cat.No: TMA0716

Target: Others

L-Carnitine hydrochloride

Cat.No: T20123

Synonym: L-Carnitine chloride,LC 80,Levocarnitine chloride,(R)-Carnitine hydrochloride,LC-80,LC80

Isobutyryl-L-carnitine

Cat.No: T19381

Target: 5-HT Receptor

L-Palmitoylcarnitine TFA

Cat.No: T73764

(-)-10,11-Dihydroxyfarnesol

Cat.No: T75458

Cat.No: T3837

Target: Antioxidant

Cat.No: T40582

Cat.No: TN1404

Synonym: 山金车内酯C,山金车内酯 C,Arnicolide C

Target: Others

Cat.No: T27304

Synonym: Farnesiferol-C

Cat.No: T82966

(8′α,9′β-Dihydroxy)-3-farnesylindole

Cat.No: T75441

Hydrocotarnine hydrobromide

Cat.No: TN4237

Target: Others

Cat.No: TN7122

Synonym: E-Methylarnottinin,5'-hydroxylosthole

Target: Others

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