Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Gefarnate 是一种胃炎和胃溃疡的研究药物,目前也用于研究干眼症。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
5 mg | ¥ 137 | 现货 | ||
10 mg | ¥ 186 | 现货 | ||
25 mg | ¥ 289 | 现货 | ||
50 mg | ¥ 413 | 现货 | ||
100 mg | ¥ 662 | 现货 | ||
200 mg | ¥ 973 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 297 | 现货 |
产品描述 | Gefarnate is a synthetic compound used for the treatment of gastric ulcers,and also used in the treatment of dry eye syndrome. |
体内活性 | Gefarnate stimulated mucin-like glycoprotein secretion in conjunctival tissue in a dose-dependent manner. In the rabbit dry-eye model, application of gefarnate ointment to the eyes resulted in a dose-dependent decrease in rose bengal permeability in the cornea, with the effect being significant at concentrations of ≥0.3%. In the cat dry-eye model, application of gefarnate ointment resulted in a significant decrease in the corneal fluorescein staining score[1]. |
动物实验 | Conjunctival tissue isolated from rabbits was treated with gefarnate. Mucin-like glycoprotein was detected in the culture supernatant by an enzyme-linked lectin assay. Gefarnate ointment was topically applied to eyes once daily for 7 days in the rabbit dry-eye model, in which the lacrimal glands, Harderian gland, and nictitating membrane were removed, or for 4 weeks in the cat dry-eye model, in which the lacrimal gland and nictitating membrane were removed. Corneal epithelial damage was evaluated by measurement of corneal permeability by rose bengal in the rabbit model or by fluorescein staining in the cat model[1]. |
分子量 | 400.64 |
分子式 | C27H44O2 |
CAS No. | 51-77-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (249.60 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.496 mL | 12.48 mL | 24.9601 mL | 62.4002 mL |
5 mM | 0.4992 mL | 2.496 mL | 4.992 mL | 12.48 mL | |
10 mM | 0.2496 mL | 1.248 mL | 2.496 mL | 6.24 mL | |
20 mM | 0.1248 mL | 0.624 mL | 1.248 mL | 3.12 mL | |
50 mM | 0.0499 mL | 0.2496 mL | 0.4992 mL | 1.248 mL | |
100 mM | 0.025 mL | 0.1248 mL | 0.2496 mL | 0.624 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Gefarnate 51-77-4 Others Inhibitor inhibit inhibitor