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29

抑制剂 & 化合物

17

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T22012	7BIO	FLT; DYRK; Aurora Kinase	Angiogenesis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Tyrosine Kinase/Adaptors
	7BIO 是靛玉红的衍生物，抑制细胞周期蛋白依赖性激酶5 和糖原合酶激酶-3β。它抑制 Aβ 寡聚体诱导的神经炎症、突触损伤、tau 过度磷酸化、星形胶质细胞和小胶质细胞的活化，并减轻 Aβ 寡聚体诱导的小鼠认知障碍。
T13036L	Sulfosuccinimidyl oleate sodium Sulfo-N-succinimidyl oleate sodium	Others	Others
	Sulfosuccinimidyl oleate sodium (Sulfo-N-succinimidyl oleate sodium) 是一种长链脂肪酸。它可以抑制脂肪酸转运到细胞中。它具有抗炎作用。
T4450	GIBH-130	IL Receptor; TNF; Interleukin	Apoptosis; Immunology/Inflammation
	GIBH130 是一种有效的神经炎症抑制剂，可作用于活化的小胶质细胞，明显抑制IL-1β的分泌(IC50:3.4 nM)。
T15622	JNJ-54175446 JNJ-5446	P2X Receptor	Membrane transporter/Ion channel; Neuroscience
	JNJ-54175446 (JNJ-5446) 是一种具有中枢神经系统渗透性和选择性的 P2X7 受体拮抗剂，可减弱小胶质细胞 IL-1β/IL-18 的释放，可用于研究抑郁症。
T2498	Adjudin AF-2364	Chloride channel; Mitochondrial Metabolism	Membrane transporter/Ion channel; Metabolism
	Adjudin (AF-2364) 是广泛研究的男性避孕试剂，可通过抑制 NF-κB 通路来减弱小胶质细胞的活化。
T9125	Tolebrutinib PRN2246,SAR442168	BTK	Angiogenesis; Tyrosine Kinase/Adaptors
	Tolebrutinib (PRN2246) 是一种选择性、有效的、具有口服活性、可透过血脑屏障的布鲁顿氏酪氨酸激酶抑制剂，能够作用于 Ramos B 细胞 (IC50:0.4 nM)、HMC 小胶质细胞 (IC50:0.7 nM)。它对中枢神经系统免疫具有功效。它可用于多发性硬化症的研究。
T33535	MW01-2-151SRM MW 151,MW-151,MW012151SRM,MW151,MW01 2 151SRM	Others	Others
	MW01-2-151SRM 是一种新型可穿过血脑屏障的小分子小胶质细胞活化抑制剂，具有抗神经炎作用，可减弱神经炎症模型中的神经胶质细胞因子上调，可用研究创伤性脑损伤、阿尔茨海默病和海藻氨酸毒性。
T63016	Nrf2 activator-4	Reactive Oxygen Species; Nrf2	Immunology/Inflammation; Metabolism; NF-κB
	Nrf2 activator-4 是一种具有口服活性的 Nrf2 激活剂（EC50: 0.63 μM），对小神经胶质细胞中活性氧的产生有抑制作用，用于治疗人类代谢功能障碍相关的脂肪肝病。
T71863	LDDN-0003499
	LDDN-0003499 is a novel Src family tyrosine kinase inhibitor with anti-inflammatory effects in response to Aß stimulation of microglia.
T15463	(Rac)-HAMI 3379 HAMI 3379	Others	Others
	HAMI 3379 is a potent and selective antagonist of the Cysteinyl leukotriene (CysLT2) receptor. HAMI 3379 has a protective effect on acute and subacute ischemic brain injury. It also attenuates microglia-related inflammation.
T24161	IMM-H004 IMMH 004,IMMH-004,IMMH004
	IMM-H004 is an effective inhibitor of BV2 microglia activation.
T40849	C20 Ceramide N-Arachidoyl-D-sphingosine	Endogenous Metabolite	Metabolism
	C20 Ceramide (N-Arachidoyl-D-sphingosine) 是一种存在于大脑中的 20:0 神经酰胺，可穿越血脑屏障激活小胶质细胞，诱导抑郁样行为。
T63364	Nrf2 activator-5
	Nrf2 activator-5 是 Nrf2 的有效激活剂，能够减轻 BV-2 小胶质细胞中 H2O2诱导的氧化应激和 LPS 刺激的炎症，表现出抗氧化和抗炎活作用。
T83962	C 101248
	C 101248是一种选择性且强效的小鼠和人类串联孔道卤素抑制K+通道1（THIK-1, IC50= 50 nM）抑制剂，对K2P家族成员TREK-1和TWIK-2以及Kv2.1无活性。C 101248能够阻断小鼠海马微胶质细胞中THIK-1 K+电流的整细胞膜片钳记录中的音调和ATP激发的电流。C 101248通过防止NLRP3依赖性IL-1β的释放，从而减少在分离的微胶质细胞中的神经炎症。
T37390	NS 6740
	High affinity α7 nAChR partial agonist (Ki = 1.1 nM in rat; Emax < 10% of the response to ACh in rat and human). Inhibits ACh (IC50 = 2.7 nM) at α7 nAChR. Reduces LPS-induced TNF-α release from microglia enriched cultures. Anti-inflammatory. Briggs et al (2009) Role of channel activation in cognitive enhancement mediated by α7 nicotinic acetylcholine receptors. Br.J.Pharmacol. 158 1486 PMID:19845675 \|Thomsen et al (2012) The α7 nicotinic acetylcholine receptor ligands methyllycaconitine, NS674...
T79590	Anti-neuroinflammation agent 1	NOD-like Receptor (NLR)	Immunology/Inflammation
	Anti-neuroinflammation agent 1 为一种效力显著的抗神经炎症药物，能有效调节BV2小胶质细胞从M1表型向M2表型极化。
T61709	AMS-17
	AMS-17 is a potent NLRP3 inhibitor, which effectively suppresses microglia activation both in vitro and in vivo. Additionally, AMS-17 exhibits inhibitory effects on various cytokines, such as caspase-1, TNF-α, IL-1β, and inducible nitric oxide synthase (iNOS), in N9 cells. Given these properties, AMS-17 holds promise as a valuable tool for investigating inflammation-associated neurological disorders [1].
T80422	Phoenixin-14 PNX-14	GNRH Receptor	GPCR/G Protein
	Phoenixin-14 (PNX-14) 是一种具有内源性活性的异构体，能通过激活AHA GnRH系统发挥抗焦虑效果，并抑制缺血/再灌注所诱导的小胶质细胞毒性。
T64205	HAMI 3379
	HAMI 3379 是一种有效的、选择性的 CysLT2 受体拮抗剂。HAMI 3379 对急性和亚急性缺血性脑损伤表现出保护效果，且可以减少小胶质细胞相关炎症。
T82763	CD33 splicing modulator 1 hydrochloride
	"CD33splicing modulator 1 (Compound 1) hydrochloride 是一种调节CD33/Siglec 3活性的化合物。CD33/Siglec 3 为髓系细胞表面受体，涉及小胶质细胞功能。该化合物通过提升细胞mRNA池中外显子2的剪接变异，展现在神经退行性疾病研究中的应用潜力，包括阿尔茨海默病。"
T37697L	D-GsMTx4 TFA	TRP/TRPV Channel; Piezo Channel	Membrane transporter/Ion channel
	D-GsMTx4 TFA 是一种具有选择性的蜘蛛毒液肽，是一种TRPC1 / 6和Piezo2抑制剂，可抑制属于 Piezo 和 TRP 通道家族的阳离子可渗透的机械敏感性通道（MSCs），阻断阳离子选择性的拉伸激活通道（SAC），减弱溶血磷脂酰胆碱（LPC）诱导的星形胶质细胞毒性和小胶质细胞反应性。D-GsMTx4 TFA 在小鼠缺血/再灌注模型中预防心肌梗死，可用于鉴定兴奋性 MSC 在正常生理学和病理学中的作用。
T35593	Semapimod tetrahydrochloride CPSI-2364 tetrahydrochloride	TLR; MAPK	Immunology/Inflammation; MAPK
	Semapimod tetrahydrochloride (CPSI-2364 tetrahydrochloride) 是一种合成鸟腙丝裂原活化蛋白激酶阻滞剂,也是促炎细胞因子生成抑制剂，干扰巨噬细胞和小胶质细胞功能。Semapimod tetrahydrochloride 可抑制 TLR4 信号传导，抑制 TNF-α、IL-1β 和 IL-6，可用于研究克罗恩病和其他炎症。
T74779	JNJ-28583113
	JNJ-28583113 是一种具有脑透性的 TRPM2拮抗剂。JNJ-28583113 抑制 TRPM2 阻断 GSK3α和β亚基的磷酸化。JNJ-28583113 保护细胞免受氧化应激诱导的细胞死亡。JNJ-28583113 还抑制小胶质细胞响应促炎刺激而释放细胞因子。
T72646	Asperbisabolane L
	Asperbisabolane L 是一种倍半萜类化合物，通过抑制NF-κB 活化途径发挥抗炎活性。Asperbisabolane L 抑制NF-κB 从细胞质转移到细胞核。Asperbisabolane L 作用于 LPS 激活的 BV-2 小胶质细胞，还抑制 NO 产生。
T78698	Aβ-IN-6
	Aβ-IN-6降低小胶质细胞释放的促炎细胞因子，能有效促进Nrf2核转位并抑制Aβ寡聚体的形成。通过调节体内氧化应激的氧化还原敏感信号通路，Aβ-IN-6展现出一致的神经保护效应。具有口服活性的Aβ-IN-6表现出抗炎、抗氧化和抗寡聚特性，并显示出作为阿尔茨海默病(AD)治疗研究潜力。
T13036	Sulfosuccinimidyl oleate Sulfo-N-succinimidyl oleate	Mitophagy	Autophagy
	Sulfosuccinimidyl oleate (Sulfo-N-succinimidyl oleate) (Sulfo-N-succinimidyl oleate) 是一种长链脂肪酸，可抑制脂肪酸运输到细胞。Sulfosuccinimidyl oleate 是一种有效且不可逆的线粒体呼吸链抑制剂。Sulfosuccinimidyl oleate 与小胶质细胞表面上的CD36受体结合，具有抗炎效果。
T62468	CB1/2 agonist 1
	CB1/2 agonist 1 是一种有效的、能够透过血脑屏障的 CB1/2 激动剂，能够作用于 CB1R (EC50: 56.15 nM) 和 CB2R (EC50: 11.63 nM)。CB1/2 agonist 1 能够降低谷氨酸释放，并减少 LPS 诱导的小胶质细胞活化，具有抗炎和镇痛活性。CB1/2 agonist 1 具有潜力进行多发性硬化症的研究。
T83734	PapRIV TFA
	PapRIV是最初从B. cereus分离出的一种群体感应七肽。它被转译为一个48-氨基酸多肽，由NprB蛋白酶在细胞外分泌和加工形成活性七肽。PapRIV（1-25 µM）在BV-2微胶质细胞中诱导IL-6和TNF-α的产生，并促使NF-κB转移。
T35468	(±)19(20)-EDP Ethanolamide
	(±)19(20)-EDP ethanolamide is an ω-3 endocannabinoid epoxide and cannabinoid (CB) receptor agonist (EC50s = 108 and 280 nM for CB1 and CB2, respectively). It is produced through direct epoxygenation of docosahexaenoyl ethanolamide by cytochrome P450 (CYP) epoxygenases. (±)19(20)-EDP ethanolamide (25 μM) reduces the viability of 143B metastatic osteosarcoma cells. It decreases the production of IL-6 and increases the production of IL-10 when used at concentrations ranging from 2.5 to 10 μM in BV-...

化合物

Cat.No: T22012

Target: FLT, DYRK, Aurora Kinase

Sulfosuccinimidyl oleate sodium

Cat.No: T13036L

Synonym: Sulfo-N-succinimidyl oleate sodium

Target: Others

Cat.No: T4450

Target: IL Receptor, TNF, Interleukin

Cat.No: T15622

Synonym: JNJ-5446

Target: P2X Receptor

Cat.No: T2498

Synonym: AF-2364

Target: Chloride channel, Mitochondrial Metabolism

Cat.No: T9125

Synonym: PRN2246,SAR442168

Target: BTK

Cat.No: T33535

Synonym: MW 151,MW-151,MW012151SRM,MW151,MW01 2 151SRM

Target: Others

Nrf2 activator-4

Cat.No: T63016

Target: Reactive Oxygen Species, Nrf2

Cat.No: T71863

(Rac)-HAMI 3379

Cat.No: T15463

Synonym: HAMI 3379

Target: Others

Cat.No: T24161

Synonym: IMMH 004,IMMH-004,IMMH004

Cat.No: T40849

Synonym: N-Arachidoyl-D-sphingosine

Target: Endogenous Metabolite

Nrf2 activator-5

Cat.No: T63364

Cat.No: T83962

Cat.No: T37390

Anti-neuroinflammation agent 1

Cat.No: T79590

Target: NOD-like Receptor (NLR)

Cat.No: T61709

Cat.No: T80422

Synonym: PNX-14

Target: GNRH Receptor

Cat.No: T64205

CD33 splicing modulator 1 hydrochloride

Cat.No: T82763

Cat.No: T37697L

Target: TRP/TRPV Channel, Piezo Channel

Semapimod tetrahydrochloride

Cat.No: T35593

Synonym: CPSI-2364 tetrahydrochloride

Target: TLR, MAPK

Cat.No: T74779

Asperbisabolane L

Cat.No: T72646

Cat.No: T78698

Sulfosuccinimidyl oleate

Cat.No: T13036

Synonym: Sulfo-N-succinimidyl oleate

Target: Mitophagy

CB1/2 agonist 1

Cat.No: T62468

Cat.No: T83734

(±)19(20)-EDP Ethanolamide

Cat.No: T35468

Cat. No.	Product Name	Target	Signaling Pathways
T5575	Cycloastragenol 环黄芪醇,Cyclogalegenol,Astramembrangenin	Epigenetic Reader Domain; Telomerase	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Cycloastragenol (Astramembrangenin) 是一种三萜皂苷类化合物，是黄芪主要活性成分的水解产物，具有抗氧化、抗炎、抗衰老、抗凋亡和心血管保护作用。它是端粒酶激活剂，可以延长端粒，还能缓解与年龄相关的骨丢失，改善骨微结构和生物力学特性。
TN1219	20-Hydroxyganoderic acid G
	20-Hydroxyganoderic acid G 是从灵芝 (Ganoderma curtisii) 子实体乙醇提取物中获得的羊毛甾烷三萜类化合物。20-Hydroxyganoderic Acid G 对由 LPS 激活的 BV-2 小胶质细胞有抑制作用，IC50 值为 21.33 μM。20-Hydroxyganoderic Acid G 用于研究由LPS 激活的小胶质细胞相关的神经炎症疾病。
T5S2283	Sesamolin	p38 MAPK; Caspase; JNK	Apoptosis; MAPK; Proteases/Proteasome
	Sesaminol 是从Justicia orbiculata 中分离得到的一种天然产物，抑制脂质过氧化，具有神经保护作用和抗氧化活性。它通过抑制JNK、p38 MAPKs 和caspase-3磷酸化，抑制MAPK 的级联反应。
TJS1779	Protosappanin A 原苏木素A,PTA	NADPH-oxidase; IL Receptor; IκB/IKK; TNF; NF-κB; TLR; ROS; COX; HIV Protease; JAK; NO Synthase; STAT	Angiogenesis; Apoptosis; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; Microbiology/Virology; Neuroscience; NF-κB; Proteases/Proteasome; Stem Cells
	Protosappanin A (PTA) 是从苏木中分离得到的免疫抑制成分和主要联苯化合物，通过下调 JAK2和 STAT3的磷酸化，抑制 JAK2/STAT3依赖的炎症通路。
T6S1917	Schisandrol B Gomisin A,TJN-101,Besigomsin,五味子醇乙,Gamma-Schisandrin,戈米辛A,Schizandrol B,Wuweizi alcohol-B	P450; Reactive Oxygen Species; Autophagy	Autophagy; Immunology/Inflammation; Metabolism; NF-κB
	Schisandrol B (Besigomsin) 是华中五味子的主要活性成分，具有保肝、抗炎、抗糖尿病和抗氧化的作用。它抑制活性氧的产生，也抑制 P-糖蛋白和CYP3A 的活性。
T3826	Polygalasaponin F 异牡荆苷,瓜子金皂苷己	NF-κB; TLR; Akt; PI3K	Cytoskeletal Signaling; Immunology/Inflammation; NF-κB; PI3K/Akt/mTOR signaling
	Polygalasaponin F 是从瓜子金中提取的齐墩果烷型三萜皂苷，可通过调节TLR4-PI3K/AKT-NF-kB 信号通路减少神经炎症细胞因子的分泌，能降低炎性细胞因子肿瘤坏死因子 α 的释放。
T39385	15a-Hydroxy-3,11,23-trioxo-lanost-8,20-dien-26-oic acid
	15a-Hydroxy-3,11,23-trioxo-lanost-8,20-dien-26-oic acid is a Lanostane triterpenoid compound with the ability to inhibit NO production in LPS-induced microglia.
TN3519	Bisdehydroneotuberostemonine	Others	Others
	Bisdehydroneotuberostemonine shows significant inhibitory effect on lipopolysaccharide-induced nitric oxide production in BV2 microglia at 100 uM.
T39386	(3β,7β,12β,20Z)-3,7,12-Trihydroxy-11,15,23-trioxo-lanost-8,20-dien-26-oic acid
	(3β,7β,12β,20Z)-3,7,12-Trihydroxy-11,15,23-trioxo-lanost-8,20-dien-26-oic acid, a lanostane triterpenoid, demonstrates significant inhibitory effects on nitric oxide (NO) production in BV-2 microglia cells induced by n LPS, with an IC50 value of 9.55 uM. Moreover, this compound possesses anti-inflammatory properties.
TN6524	Irilone
	Irilone has immunomodulatory, and α-amylase inhibitory activities, it exhibits the selective inhibition toward CYP3 A4 rather than other major human CYPs. Irilone exhibited prominent antioxidant activities with the IC50 value of 10.46μM. Irilone potentiat
T5157	9,13-Epidioxy-8(14)-abieten-18-oic acid	Others	Others
	9,13β-Epidioxy-8(14)-abieten-18-oic acid has anti-inflammatory activities, it exhibits moderate activities on NO levels in LPS-stimulated murine microglia BV2 cells, with IC50 values of 57.3 ± 0.2 uM. It is also a potential antitumor-promoting diterpenoid, it shows potent inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol 13-acetate. 9 α ,13 β -Epidioxyabeit-8(14)en-18-oic acid may contribute to the growth inhibitory...
T4S0823	Astragaloside	Others	Others
	Astragaloside 能够保护大鼠海马形态结构，恢复乙酰胆碱水平，并能够使脑电图正常化改善脑功能。
T37272	9(S),12(S),13(S)-TriHOME
	9(S),12(S),13(S)-TriHOME is a linoleic acid-derived oxylipin that has diverse biological activities.1,2,3,4It has been found in various plants and is produced in human eosinophils in a 15-lipoxygenase-dependent, soluble epoxide hydrolase-independent manner.1,59(S),12(S)13(S)-TriHOME inhibits antigen-induced β-hexosaminidase release from RBL-2H3 mast cells (IC50= 28.7 μg/ml).2It inhibits LPS-induced nitric oxide (NO) production in BV-2 microglia (IC50= 40.95 μM).3In vivo, 9(S),12(S),13(S)-TriHOME...
TN5011	Shizukaol B	ERK; IL Receptor; p38 MAPK; TNF; NOS; NF-κB; COX; HIV Protease; DNA/RNA Synthesis; Prostaglandin Receptor; JNK	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; GPCR/G Protein; Immunology/Inflammation; MAPK; Microbiology/Virology; Neuroscience; NF-κB; Proteases/Proteasome
	Shizukaol B exerts anti-inflammatory effects in LPS-activated microglia partly by modulating JNK-AP-1 signaling pathway; it also shows significant anti-neuroinflammatory effects by inhibiting nitric-oxide (NO) production in lipopolysaccharide (LPS)-stimul
TN3587	Capillarisin	MMP; ERK; IL Receptor; BCL; VEGFR; TNF; NOS; NF-κB; TLR; MAPK; COX; DNA/RNA Synthesis; Prostaglandin Receptor; JNK; STAT	Angiogenesis; Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; GPCR/G Protein; Immunology/Inflammation; JAK/STAT signaling; MAPK; Neuroscience; NF-κB; Proteases/Proteasome; Stem Cells; Tyrosine Kinase/Adaptors
	Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cells, it inhibits cancer cell growth of osteosarcoma cells by inducing apoptosis accompanied with
TN2517	1,7-Dihydroxy-2,3-dimethoxyxanthone	Others	Others
	1,7-Dihydroxy-2,3-dimethoxyxanthone may have medicinal use in the management of inflammation, asthma and allergy, it antagonises in a non competitive but, reversible manner the contractions induced by chemical inflammatory mediators in the guinea pig trac
TN5901	Cudratricusxanthone A
	Cudratricusxanthone A has potent anti-proliferative, antioxidative, and monoamine oxidase inhibitory effects, it also possesses anti-cancer activities and provide a basis for developing effective therapeutic agents to inhibit growth and metastasis of brea

天然产物

Cycloastragenol

Cat.No: T5575

Synonym: 环黄芪醇,Cyclogalegenol,Astramembrangenin

Target: Epigenetic Reader Domain, Telomerase

20-Hydroxyganoderic acid G

Cat.No: TN1219

Cat.No: T5S2283

Target: p38 MAPK, Caspase, JNK

Protosappanin A

Cat.No: TJS1779

Synonym: 原苏木素A,PTA

Target: NADPH-oxidase, IL Receptor, IκB/IKK, TNF, NF-κB, TLR, ROS, COX, HIV Protease, JAK, NO Synthase, STAT

Cat.No: T6S1917

Synonym: Gomisin A,TJN-101,Besigomsin,五味子醇乙,Gamma-Schisandrin,戈米辛A,Schizandrol B,Wuweizi alcohol-B

Target: P450, Reactive Oxygen Species, Autophagy

Polygalasaponin F

Cat.No: T3826

Synonym: 异牡荆苷,瓜子金皂苷己

Target: NF-κB, TLR, Akt, PI3K

15a-Hydroxy-3,11,23-trioxo-lanost-8,20-dien-26-oic acid

Cat.No: T39385

Bisdehydroneotuberostemonine

Cat.No: TN3519

Target: Others

(3β,7β,12β,20Z)-3,7,12-Trihydroxy-11,15,23-trioxo-lanost-8,20-dien-26-oic acid

Cat.No: T39386

Cat.No: TN6524

9,13-Epidioxy-8(14)-abieten-18-oic acid

Cat.No: T5157

Target: Others

Cat.No: T4S0823

Target: Others

9(S),12(S),13(S)-TriHOME

Cat.No: T37272

Cat.No: TN5011

Target: ERK, IL Receptor, p38 MAPK, TNF, NOS, NF-κB, COX, HIV Protease, DNA/RNA Synthesis, Prostaglandin Receptor, JNK

Cat.No: TN3587

Target: MMP, ERK, IL Receptor, BCL, VEGFR, TNF, NOS, NF-κB, TLR, MAPK, COX, DNA/RNA Synthesis, Prostaglandin Receptor, JNK, STAT

1,7-Dihydroxy-2,3-dimethoxyxanthone

Cat.No: TN2517

Target: Others

Cudratricusxanthone A

Cat.No: TN5901

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