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Sulfosuccinimidyl oleate

Sulfosuccinimidyl oleate

产品编号 T13036   CAS 135661-44-8
别名: Sulfo-N-succinimidyl oleate

Sulfosuccinimidyl oleate (Sulfo-N-succinimidyl oleate) (Sulfo-N-succinimidyl oleate) 是一种长链脂肪酸,可抑制脂肪酸运输到细胞。Sulfosuccinimidyl oleate 是一种有效且不可逆的线粒体呼吸链抑制剂。Sulfosuccinimidyl oleate 与小胶质细胞表面上的CD36受体结合,具有抗炎效果。

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Sulfosuccinimidyl oleate Chemical Structure
Sulfosuccinimidyl oleate, CAS 135661-44-8
规格 价格/CNY 货期 数量
5 mg ¥ 7,000 5日内发货
50 mg ¥ 13,800 5日内发货
100 mg ¥ 17,500 5日内发货

Sulfosuccinimidyl oleate 的其他形式现货产品:

Sulfosuccinimidyl oleate sodium
其他形式的 Sulfosuccinimidyl oleate:
产品目录号及名称: Sulfosuccinimidyl oleate (T13036)
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生物活性
化学信息
存储 & 溶解度
参考文献
产品描述 Sulfosuccinimidyl oleate (Sulfo-N-succinimidyl oleate) (Sulfo-N-succinimidyl oleate) is a long chain fatty acid that inhibits fatty acid transport into cells. Sulfosuccinimidyl oleate is a potent and irreversible inhibitor of mitochondrial respiratory chain. Sulfosuccinimidyl oleate binds the CD36 receptor on the surface of microglia. Sulfosuccinimidyl oleate is neuroprotective and alleviates stroke-induced neuroinflammation [1] [2].
体外活性 Sulfosuccinimidyl oleate (20 μM and 50 μM, 24 hours) alone does not change the cellular viability. Exposure to 100 ng/ml LPS+5 ng/mL IFNγ modestly, yet significantly decreases the viability of the BV2 cells. Co-treatment with Sulfosuccinimidyl oleate prevents the LPS+IFNγ-induced reduction in the cell viability [1]. Sulfosuccinimidyl oleate (50 μM, 24 hours) co-treatment significantly reduces the LPS+IFNγ-induced expression of NOS2 and COX-2 in BV2 cells. Western blot analysis reveals a significant LPS/IFNγ-induced upregulation in the phosphorylated form of the p38, which is prevented by co-treatment with Sulfosuccinimidyl oleate (50 μM, 24 hours) [1]. Cell Viability Assay [1] Cell Line: BV2 cells Concentration: 20 μM and 50 μM Incubation Time: 24 hours Result: Did not alter the viability of BV2 cells alone. Exposure of BV2 cells to 100 ng/mL LPS and 5 ng/mL IFNγ significantly reduced the viability of BV2 cells while simultaneous treatment with Sulfosuccinimidyl oleate prevented it. Western Blot Analysis [1] Cell Line: BV2 cells Concentration: 50 μM Incubation Time: 24 hours Result: Drastically increased the levels of NOS2, COX-2, and P-p38/T-p38.
体内活性 Sulfosuccinimidyl oleate (50 mg/kg; administered once by single oral gavage) significantly reduces the cortical ischemic infarct size compared to vehicle-treated controls in male BALB/cABom mice with pMCAo model. Moreover, Sulfosuccinimidyl oleate at 50 mg/kg is suitable to see a beneficial effect after stroke [1]. Animal Model: 4-month-old male BALB/cABom mice with pMCAo model [1] Dosage: 50 mg/kg Administration: Administered once by single oral gavage Result: Reduced brain damage following ischemia. Attenuated infarct size.
别名 Sulfo-N-succinimidyl oleate
分子量 459.6
分子式 C22H37NO7S
CAS No. 135661-44-8

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器
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参考文献

1. Drahota Z, et al. Succinimidyl oleate, established inhibitor of CD36/FAT translocase inhibits complex III of mitochondrial respiratory chain. Biochem Biophys Res Commun. 2010 Jan 15;391(3):1348-51. 2. Dhungana H, et al. Sulfosuccinimidyl oleate sodium is neuroprotective and alleviates stroke-induced neuroinflammation. J Neuroinflammation. 2017 Dec 4;14(1):237.
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剂量换算

对于不同动物的给药剂量换算,您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。

体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。

第一步:请输入动物实验的基本信息
剂量
mg/kg
每只动物体重
g
给药体积
μL
动物数量
第二步:请输入动物体内配方组成,不同的产品配方组成不同,如有配方需求,可先联系我们提供正确的体内配方。
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技术支持

您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。

Keywords

Sulfosuccinimidyl oleate 135661-44-8 Autophagy Mitophagy inhibit Mitochondrial Autophagy Inhibitor Sulfo-N-succinimidyl oleate inhibitor

 

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