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Search Results for " cholesterol "

282

抑制剂 & 化合物

108

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T35973	Cholesterol-5α,6α-epoxide Epoxycholesterol,5α,6α-epoxy Cholestanol,NSC 18176	Others	Others
	Cholesterol-5α,6α-epoxide (Epoxycholesterol) 是胆固醇氧化产生的代谢产物。在应用他莫昔芬和 PBPE 后，5α,6α-环氧胆甾烷醇通过与 LXRβ 结合诱导三酰甘油生物合成。
T35977	6α-hydroxy Cholesterol 6α-hydroxy Cholesterol,6α-OHC
	6α-hydroxy Cholesterol is an oxysterol that increases superoxide anion production in SK-N-BE cells when used at concentrations of 50 and 100 μM.[1]
T36130	22(S)-hydroxy Cholesterol 22(S)-hydroxy Cholesterol,22β-hydroxy Cholesterol
	22(S)-hydroxy Cholesterol is a synthetic oxysterol and a modulator of the liver X receptor (LXR). [1] t prevents monocyte chemoattractant protein 1 (MCP-1) expression induced by the LXR agonist GW 3965 in primary hepatocytes and downregulates mRNA expression of the LXR target genes CD36, ACSL1, and SCD-1 in human myotubes. It decreases triacylglycerol and diacylglycerol synthesis from labeled palmitate and acetate, respectively, in human myoblasts by 50% when used at a concentration of 10 uM. 22...
T67509	Cholesteryl Hemisuccinate Cholesterol hydrogen succinate	Apoptosis; DNA/RNA Synthesis; Topoisomerase	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Cholesteryl Hemisuccinate (Cholesterol hydrogen succinate) 是一种经常使用在极性溶液中具有高溶解度的胆固醇类似物，具有保肝、抗癌和抑制肿瘤生长的作用。Cholesteryl Hemisuccinate 抑制对乙酰氨基酚的肝毒性，并防止 AAP 诱导的肝细胞凋亡和坏死。Cholesteryl Hemisuccinate 抑制 DNA 聚合酶和 DNA 拓扑异构酶，从而抑制 DNA 复制和修复以及细胞分裂。
T36998	7β,27-dihydroxy Cholesterol 7β,27-DHC,7β,27-dihydroxy Cholesterol
	7β,27-dihydroxy Cholesterol is an oxysterol and agonist of retinoic acid receptor-related orphan receptor γ (RORγ) and RORγt. [1] It activates RORγ- or RORγt-dependent signaling with EC50 values of 691 and 1,045 nM, respectively, in reporter assays using HEK293T cells expressing the recombinant human receptors. 7β,27-dihydroxy Cholesterol is selective for RORγ and RORγt over a panel of eight additional nuclear receptors at 30 &#181M. It increases IL-17A production in Th17-polarized isolated hum...
T41008	BODIPY-Cholesterol BCh2
	BODIPY-Cholesterol (TF-Chol)是一种带有荧光 BODIPY 基团和细胞通透性的胆固醇类似物，是一种新型 BODIPY 胆固醇探针。BODIPY-Cholesterol 可用于研究细胞内固醇摄取和细胞器间固醇通量。
T40140	Zanamivir-Cholesterol Conjugate
	Zanamivir-cholesterol conjugate is an extended-duration neuraminidase inhibitor highly effective against drug-resistant influenza strains.
T60796	Cholesterol 24-hydroxylase-IN-1
	Cholesterol 24-hydroxylase-IN-1 (compound 17) 是具有口服活性且高选择性的胆固醇24-羟化酶(CH24H or CYP46A1)抑制剂，IC50值为8.5 nM，可以穿过血脑屏障。
T36217	19-hydroxy Cholesterol
	19-hydroxy Cholesterol is formed during metabolic oxidation of cholesterol. It has been used as an internal standard for the quantitative determination of sterols by mass spectroscopic analysis.[1]
T38045	Cholesterol β-D-Glucoside
	Cholesterol β-D-glucoside is a derivative of cholesterol that contains β-D-glucose . It is formed from cholesterol and glucosylceramide by β-glucosidase 1. It activates heat shock transcription factor 1 (Hsf1) in response to heat shock, which increases the expression of heat shock protein 70 (Hsp70) in TIG-3 human fetal lung fibroblasts when used at a concentration of 10 μM. Cholesterol β-D-glucoside (100 mg/kg) prevents ulcer formation following cold-restraint stress and increases Hsf1 activity...
T21530	4β-hydroxy Cholesterol
	4β-hydroxy Cholesterol 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T21530，CAS号为 17320-10-4。
T65554	cholesterol-absorption inhibitor Intermediate 2	Others	Others
	cholesterol-absorption inhibitor Intermediate 2 是一种有效且具有口服活性的胆固醇吸收抑制剂，可降低血液中胆固醇含量。
T35236	5α-Hydroxy-6-keto cholesterol YS 64,Yakkasterone,5α-羟基-6-酮胆固醇
	Yakkasterone is a major metabolite of cholesterol formed during exposure of lung epithelial cells to ozone.
T35941	DC-Chol hydrochloride Cholesteryl 3β-N-(dimethylaminoethyl)carbamate hydrochloride,DC-Chol (hydrochloride),DC-Cholesterol hydrochloride,Cholesteryl 3β-N-(dimethylaminoethyl)carbamate	Beta Amyloid	Neuroscience
	DC-Chol hydrochloride(DC-Cholesterol hydrochloride) 在适当的实验条件下能抑制 Aβ40 纤维的形成且以剂量依赖性的方式显著抑制氧化hCT的淀粉样蛋白形成。DC-Chol hydrochloride可诱导改善和平衡的免疫力，能够促进乙型肝炎疫苗的研究。
T77231	Cholesterol nervonate
	Cholesterolnervonate 是一种生化试剂，可作为生物材料或有机化合物，用于生命科学相关研究。
T76139	Cholesterol esterase
	胆固醇酯酶 (Cholesterol esterase) 是一种在肠道内将胆固醇酯水解为胆固醇和游离脂肪酸的酶。胆固醇在腺泡细胞中合成，储存在酶原颗粒中。胆固醇酯酶又称胆盐刺激脂肪酶、羧基酯脂肪酶，具有促进胆固醇吸收的作用。
T76128	Cholesterol oxidase
	Cholesteroloxidase (ChOx)，一种含有FAD的细菌黄素氧化酶，主要应用于生化研究领域。该酶专门催化胆固醇（及其他甾醇）的C(3)-OH基团，氧化生成cholest-5-en-3-one，并进一步异构化为cholest-4-en-3-one。
T38056	Cholesteryl Arachidate Cholesterol Arachidate
	Cholesteryl arachidate is a cholesterol ester that has been found in human meibum.[1][2] It has been used as an internal standard for the quantification of fatty acids in B. napus.[3]
T65073	Cholesterol n-Octanoate
	Cholesterol n-Octanoate 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T65073，CAS号为 1182-42-9。
T82731	Cholesterol 24-hydroxylase-IN-2
	Cholesterol24-Hydroxylase-IN-2为胆固醇24-羟化酶（CH24H 或CYP46A1）抑制剂，具有5.4 nM的IC50值。该化合物适用于哺乳动物胆固醇24-羟化酶的成像研究。
T77270	Cholesterol-PEG-Folate (MW 2000)
	Cholesterol-PEG-Folate (MW 2000) 是一种辅料，可用于制备叶酸偶联 PEG 脂质体。
T14933	Cetaben	Others	Others
	Cetaben 是不依赖 PPARα 的过氧化物酶体增殖物。它可有效降低胆固醇和甘油三酸酯的浓度，是一种非纤维化降血脂药。
T35321	Zymostenol delta(8)-Cholestenol,5a-Cholest-8-en-3b-ol,Δ8-Cholesterol	Endogenous Metabolite; ROR	Metabolism
	Zymostenol (5a-Cholest-8-en-3b-ol) 是一种 RORγ 激动剂，EC50为1 μM。Zymostenol 是胆固醇生物合成的后期前体。
T4039	BIBB 515	Others	Others
	BIBB 515 是口服具有活力的 2,3-氧化角鲨烯环化酶选择性抑制剂，在大鼠和小鼠中的 ED50值分别为 0.2-0.5 mg/kg 和 0.36-33.3 mg/kg (1-5 小时)。它主要利用抑制低密度脂蛋白的产生，从而发挥降脂作用。
T7482	3-chloro-5-hydroxybenzoic Acid	GPR	Endocrinology/Hormones; GPCR/G Protein
	3-Chloro-5-hydroxybenzoic acid 是一种口服具有活力的乳酸受体GPR81选择性激动剂，对人 GPR81 的EC50为 16 μM。肥胖小鼠模型中，它表现出良好的体内脂肪分解作用。
T14362	AY 9944	Others	Others
	AY 9944 是特异性的胆固醇生物合成抑制剂。它抑制 7- 脱氢胆固醇 Δ7- 还原酶 (IC50:13 nM)，导致胆固醇不足和 7DHC 积累。在高剂量下，它可在培养的胚胎中抑制固醇 Δ7-Δ8 异构酶，造成胆固醇 8-en-3β-ol 的积累。
T27478	GSK3987	Liver X Receptor	Metabolism
	GSK3987 是广谱LXRα/β激动剂，EC50分别为 50 nM 和 40 nM。GSK3987增加 ABCA1 和 SREBP-1c 蛋白的表达，诱导细胞甘油三酯的积累和胆固醇流出。
T4524	SBC-110736 SBC110736	Others; Serine/threonin kinase	Cell Cycle/Checkpoint; Metabolism; Others
	SBC-110736 是一种蛋白转化酶枯草杆菌蛋白酶 9 型 (PCSK9) 抑制剂。
T3283	Cetilistat 新利司他,ATL-962	Lipid	Metabolism
	Cetilistat (ATL-962) 是胰腺脂肪酶 (pancreatic lipase) 抑制剂，能够抑制大鼠脂肪酶(IC50:54.8 nM)和人胰脂肪酶(IC50:5.95 nM)的活性，可用作有效的抗肥胖药。
T23521	VULM 1457	Acyltransferase	Metabolism
	VULM 1457 是有效的胆固醇酰基转移酶抑制剂，具有显著的降血脂活性，并改善了整体心肌缺血再灌注损伤结果。VULM 1457 显著降低肾上腺髓质素的产生和分泌，并下调人肝母细胞上的 AM 受体。VULM 1457 具有研究糖尿病和高胆固醇血症的潜力。
T23550	YM-750 YM 750	Acyltransferase	Metabolism
	YM-750 是一种有效的酰基:胆固醇酰基转移酶(ACAT)抑制剂，IC50为0.18 μM。
T8937	Soticlestat TAK-935,OV935	P450	Metabolism
	Soticlestat (OV935) 是一种首创的、口服有活性的胆固醇 24-羟化酶 (cholesterol 24-hydroxylase, CH24H) 选择性抑制剂。它可用于研究癫痫综合征。
T1676	Rosuvastatin 罗伐他汀,ZD 4522,瑞舒伐他汀	Potassium Channel; HMG-CoA Reductase; Autophagy	Autophagy; Membrane transporter/Ion channel; Metabolism
	Rosuvastatin (ZD 4522) 是一种抗血脂药，可竞争性抑制羟甲基戊二酰辅酶 A 还原酶，用于降低血浆胆固醇水平和预防心血管疾病。它降低低密度脂蛋白胆固醇、甘油三酯和 C-反应蛋白水平。它阻断人类醚-a-go-go 相关基因电流，IC50为 195 nM，延迟心脏复极化，延长动作电位持续时间和校正 QT 间期间隔。
T6048	Dalcetrapib JTT-705,达塞曲匹,RO4607381	CETP	Metabolism
	Dalcetrapib (RO4607381) 是rhCETP 抑制剂(IC50:0.2 μM)，具有增加血浆中HDL 胆固醇含量的作用。
T2499	Torcetrapib CP-529414,托彻普	CETP	Metabolism
	是胆固醇酯转移蛋白 (CETP) 选择性抑制剂。根据人血浆的抑制曲线，Torcetrapib (CP-529414) 对CETP 的最有效浓度为 37 nM。
T26296	Triparanol 曲帕拉醇,MER-29,NSC 65345,NSC-65345,NSC65345	Apoptosis; Hedgehog/Smoothened	Apoptosis; GPCR/G Protein; Stem Cells
	Triparanol (NSC-65345) 干扰 Hedgehog 信号分子的翻译后修饰以及其受体 PTCH1 的甾醇传感域，导致 Hedgehog 信号的下调。 Triparanol 抑制人类肿瘤生长，是一种具有高眼毒性的抗血脂剂。
T1199	Mitotane Mitotan,o,p'-DDD,NCI-C04933,2,4′-DDD,米托坦	Apoptosis; AChR	Apoptosis; Neuroscience
	Mitotane (NCI-C04933) 是 DDD 的同分异构体和 DDT 的衍生物，可作用于肾上腺皮质癌，有抗癌活性。
T1510	Rosuvastatin calcium ZD 4522 Calcium,ZD4522,Rosuvastatin hemicalcium,瑞舒伐他汀钙	Potassium Channel; HMG-CoA Reductase; Autophagy	Autophagy; Membrane transporter/Ion channel; Metabolism
	Rosuvastatin calcium (ZD4522) 是肝羟甲基戊二酰辅酶 A 还原酶的选择性和竞争性抑制剂，具有抗血脂活性。它降低成熟 hERG 的表达以及热休克蛋白 70 与 hERG 蛋白的相互作用，还降低低密度脂蛋白胆固醇、甘油三酯和 C-反应蛋白水平。它阻断人类醚-a-go-go 相关基因电流，延迟心脏复极化，来延长动作电位持续时间和校正 QT 间期间隔。
T38996	4α-Methylcholesterol
	4α-Methylcholesterol, a derivative of Cholesterol, possesses the ability to oxidize 3-hydroxy steroid at an apparent K m of 12.6 μM.
T77264	Thiocholesterol
	Thiocholesterol 是一种胆固醇衍生物，常用于合成阳离子脂质液态晶体 (CLCs)。它也作为纳米银 (SNP) 的有效稳定剂。此外，Thiocholesterol 在质膜研究和药物递送领域有重要应用。
T71756	24(S),25-Epoxycholesterol
	24(S),25-Epoxycholesterol is an oxysterol agonist of the liver X receptor.
T67835	LKM38
	LKM38是一种新型的重氮烷基胆固醇探针，是一种有前途的胆固醇模拟物。LKM38既能维持抗胆固醇细胞的生长，又能适当地调节关键的胆固醇平衡途径。LKM38可以作为研究胆固醇蛋白相互作用和贩运的有力工具。
T1593	Ezetimibe 依泽替米贝,SCH 58235	Others; Nrf2; NPC1L1; Autophagy	Autophagy; Immunology/Inflammation; Membrane transporter/Ion channel; Others
	Ezetimibe (SCH 58235) 是一种膳食胆固醇吸收抑制剂。它是一种NPC1L1抑制剂，是有效的Nrf2激活剂。
T19239	Cicloxilic acid Cycloxilic acid	Others	Others
	Cicloxilic acid（Cycloxilic acid）具有利胆活性，抑制胆汁胆固醇的输出。
T25276	Crilvastatin PMD387,PMD 387,PMD-387	HMG-CoA Reductase	Metabolism
	Crilvastatin (PMD 387) 是一种新型非竞争性羟甲基戊二酰辅酶 A 还原酶抑制剂，具有降胆固醇活性，可抑制遗传性高胆固醇血症大鼠的胆固醇吸收。
T36126	TMP-153
	Acyl-CoA:cholesterol acyltransferase (ACAT) catalyses the esterification of excess cellular cholesterol with fatty acids and is important for intestinal cholesterol absorption, hepatic lipoprotein secretion, and cholesterol accumulation in vascular tissues. ACAT inhibitors improve plasma lipid profile and ameliorate proteinuria in nephrotic animals. TMP-153 is a quinolyl derivative that inhibits ACAT with IC50 values of 5-10 nM in various animals. At 0.5-1.5 mg/kg, TMP-153 dose-dependently reduc...
T68042	CHF-4227 Chf4227,Chf 4227	Estrogen Receptor/ERR	Endocrinology/Hormones
	CHF-4227 是一种新型高效且具有选择性的雌激素受体调节剂，可降低胆固醇合低密度脂蛋白胆固醇浓度。
T15549	Icosabutate	Others	Others
	Icosabutate is a structurally engineered and orally active ω-3 polyunsaturated fatty acid. Icosabutate is well tolerated, and efficacious in lowering non-high-density lipoprotein cholesterol (non-HDL-C) levels in persistent hypertriglyceridemia.
T1928	Anacetrapib 安塞曲匹,MK-0859	CETP	Metabolism
	Anacetrapib (MK-0859) 是 CETP 的抑制剂，能够抑制 rhCETP (IC50:7.9±2.5 nM) 和 C13S CETP 突变型 (IC50:11.8±1.9 nM) 的活性。
T25285	Dalvastatin RG-12561,RG 12561,RG12561	HMG-CoA Reductase	Metabolism
	Dalvastatin (RG-12561) 是一种可口服的 HMG-CoA 还原酶和降胆固醇合成的抑制剂。Dalvastatin 竞争性地抑制大鼠肝脏HMG-CoA还原酶，IC50值为3.4 nmol / l。 Dalvastatin 在在大鼠实验中，抑制肝切片中的胆固醇生物合成，ED50值为0.9。

化合物

Cholesterol-5α,6α-epoxide

Cat.No: T35973

Synonym: Epoxycholesterol,5α,6α-epoxy Cholestanol,NSC 18176

Target: Others

6α-hydroxy Cholesterol

Cat.No: T35977

Synonym: 6α-hydroxy Cholesterol,6α-OHC

22(S)-hydroxy Cholesterol

Cat.No: T36130

Synonym: 22(S)-hydroxy Cholesterol,22β-hydroxy Cholesterol

Cholesteryl Hemisuccinate

Cat.No: T67509

Synonym: Cholesterol hydrogen succinate

Target: Apoptosis, DNA/RNA Synthesis, Topoisomerase

7β,27-dihydroxy Cholesterol

Cat.No: T36998

Synonym: 7β,27-DHC,7β,27-dihydroxy Cholesterol

BODIPY-Cholesterol

Cat.No: T41008

Synonym: BCh2

Zanamivir-Cholesterol Conjugate

Cat.No: T40140

Cholesterol 24-hydroxylase-IN-1

Cat.No: T60796

19-hydroxy Cholesterol

Cat.No: T36217

Cholesterol β-D-Glucoside

Cat.No: T38045

4β-hydroxy Cholesterol

Cat.No: T21530

cholesterol-absorption inhibitor Intermediate 2

Cat.No: T65554

Target: Others

5α-Hydroxy-6-keto cholesterol

Cat.No: T35236

Synonym: YS 64,Yakkasterone,5α-羟基-6-酮胆固醇

DC-Chol hydrochloride

Cat.No: T35941

Synonym: Cholesteryl 3β-N-(dimethylaminoethyl)carbamate hydrochloride,DC-Chol (hydrochloride),DC-Cholesterol hydrochloride,Cholesteryl 3β-N-(dimethylaminoethyl)carbamate

Target: Beta Amyloid

Cholesterol nervonate

Cat.No: T77231

Cholesterol esterase

Cat.No: T76139

Cholesterol oxidase

Cat.No: T76128

Cholesteryl Arachidate

Cat.No: T38056

Synonym: Cholesterol Arachidate

Cholesterol n-Octanoate

Cat.No: T65073

Cholesterol 24-hydroxylase-IN-2

Cat.No: T82731

Cholesterol-PEG-Folate (MW 2000)

Cat.No: T77270

Cat.No: T14933

Target: Others

Cat.No: T35321

Synonym: delta(8)-Cholestenol,5a-Cholest-8-en-3b-ol,Δ8-Cholesterol

Target: Endogenous Metabolite, ROR

Cat.No: T4039

Target: Others

3-chloro-5-hydroxybenzoic Acid

Cat.No: T7482

Target: GPR

Cat.No: T14362

Target: Others

Cat.No: T27478

Target: Liver X Receptor

Cat.No: T4524

Synonym: SBC110736

Target: Others, Serine/threonin kinase

Cat.No: T3283

Synonym: 新利司他,ATL-962

Target: Lipid

Cat.No: T23521

Target: Acyltransferase

Cat.No: T23550

Synonym: YM 750

Target: Acyltransferase

Cat.No: T8937

Synonym: TAK-935,OV935

Target: P450

Cat.No: T1676

Synonym: 罗伐他汀,ZD 4522,瑞舒伐他汀

Target: Potassium Channel, HMG-CoA Reductase, Autophagy

Cat.No: T6048

Synonym: JTT-705,达塞曲匹,RO4607381

Target: CETP

Cat.No: T2499

Synonym: CP-529414,托彻普

Target: CETP

Cat.No: T26296

Synonym: 曲帕拉醇,MER-29,NSC 65345,NSC-65345,NSC65345

Target: Apoptosis, Hedgehog/Smoothened

Cat.No: T1199

Synonym: Mitotan,o,p'-DDD,NCI-C04933,2,4′-DDD,米托坦

Target: Apoptosis, AChR

Rosuvastatin calcium

Cat.No: T1510

Synonym: ZD 4522 Calcium,ZD4522,Rosuvastatin hemicalcium,瑞舒伐他汀钙

Target: Potassium Channel, HMG-CoA Reductase, Autophagy

4α-Methylcholesterol

Cat.No: T38996

Thiocholesterol

Cat.No: T77264

24(S),25-Epoxycholesterol

Cat.No: T71756

Cat.No: T67835

Cat.No: T1593

Synonym: 依泽替米贝,SCH 58235

Target: Others, Nrf2, NPC1L1, Autophagy

Cicloxilic acid

Cat.No: T19239

Synonym: Cycloxilic acid

Target: Others

Cat.No: T25276

Synonym: PMD387,PMD 387,PMD-387

Target: HMG-CoA Reductase

Cat.No: T36126

Cat.No: T68042

Synonym: Chf4227,Chf 4227

Target: Estrogen Receptor/ERR

Cat.No: T15549

Target: Others

Cat.No: T1928

Synonym: 安塞曲匹,MK-0859

Target: CETP

Cat.No: T25285

Synonym: RG-12561,RG 12561,RG12561

Target: HMG-CoA Reductase

Cat. No.	Product Name	Target	Signaling Pathways
T0760	Cholesterol Cholesterin,Cholesteryl alcohol,胆固醇	Estrogen Receptor/ERR; MRP; Endogenous Metabolite; ROR	Endocrinology/Hormones; Immunology/Inflammation; Metabolism
	Cholesterol (Cholesteryl alcohol) 属于天然产物，是哺乳动物中的主要固醇，是一种雌激素相关受体 α (ERRα) 的激动剂。Cholesterol 广泛存在于动物的细胞膜，也是合成几种重要荷尔蒙及胆酸的材料。
T8040	Cholesterol myristate 胆甾烯基豆蔻酸酯,Cholesteryl myristate,胆固醇肉豆蔻酸,Cholesteryl tetradecanoate	Others; Potassium Channel; GABA Receptor; Endogenous Metabolite; AChR	Membrane transporter/Ion channel; Metabolism; Neuroscience; Others
	Cholesterol myristate (Cholesteryl myristate) 是粗吻海龙中的一种类固醇，可与多种离子通道结合，例如nAChR、GABAA 受体和内向整流钾离子通道。
T2918	Cholesteryl Acetate Cholesterin acetate,胆甾醇乙酸酯,Cholesterol acetate,Acebrochol	Others	Others
	Cholesteryl Acetate 是胆固醇的羟基被乙酸形式酰化而得到的胆固醇酯。它具有作为人体代谢物的作用。它是一种胆固醇酯和一种乙酸酯。
T10805	Cholesterol glucuronide	Others	Others
	Cholesterol glucuronide is an endogenous metabolite of lipid generated by UDP glucuonyltransferase in the liver.
T19237	Cholesteryl oleate 胆固醇油酸酯,Oleoylcholesterol,Cholesterol Oleate,Cholesteryl cis-9-octadecenoate	Endogenous Metabolite	Metabolism
	Cholesteryl oleate (Cholesteryl cis-9-octadecenoate) 是胆固醇的酯化形式，可用于合成固体脂质纳米颗粒。
TQ0274	27-Hydroxycholesterol 27-羟基胆固醇,5,25R-胆甾烯-3BETA,26-二醇,25(R)-27-hydroxy Cholesterol	Estrogen/progestogen Receptor; Liver X Receptor	Endocrinology/Hormones; Metabolism
	27-Hydroxycholesterol (25(R)-27-hydroxy Cholesterol) 是一种有效的、选择性的雌激素受体调节剂和肝X 受体激动剂。
T5239	Cholesteryl sulfate sodium Cholesterol 3-Sulfate Sodium Salt,胆固醇硫酸酯钠盐,Sodium Cholesteryl Sulfate	Endogenous Metabolite; PKC	Chromatin/Epigenetic; Cytoskeletal Signaling; Metabolism
	Cholesteryl sulfate sodium (Sodium Cholesteryl Sulfate) 是内源性代谢产物的一种。
T5214	Cholesteryl linoleate CE(18:2(9Z,12Z)),Cholesterol Linoleate,Linoleic Acid cholesteryl ester,胆甾烯基亚油酸酯	Others; Endogenous Metabolite	Metabolism; Others
	Cholesteryl linoleate (Linoleic Acid cholesteryl ester) 是低密度脂蛋白和动脉粥样硬化病变中主要的胆固醇酯。它存在于 LDL 中的胆固醇酯，利用 LDL 受体相关蛋白转移到表达 15-脂氧合酶的巨噬细胞和 CHO 细胞的质膜，被氧化形成胆固醇亚油酸氢过氧化物。
T19236	Cholesteryl behenate Cholesteryl docosanoate,Cholesterol behenate,胆固醇山萮酸酯	Others	Others
	Cholesteryl behenate is a standard in electrospray ionization tandem mass spectrometry for the analysis of cholesteryl esters and cholesterol.
T2721	Digitonin	Others	Others
	Digitonin 属于糖苷类天然产物，是一种去垢剂。Digitonin 具有抗肿瘤活性，可以与胆固醇分子结合从而增加细胞膜的通透性，对多种细胞的细胞膜具有裂解活性。
TN1576	Diallyl disulfide	IL Receptor; NOS; NF-κB	Immunology/Inflammation; NF-κB
	Diallyl disulfide 能够抑制人角鲨烯单加氧酶，抑制角鲨烯环氧化的 IC50为 400 μM。它也具有抗肿瘤作用，同miR-200b 和miR-22联合使用可增强该作用。
T19161	7α-Hydroxycholesterol	Others	Others
	7α-Hydroxycholesterol 是一种由酶促氧化和非酶促氧化形成的胆固醇氧化物，可用作脂质过氧化的生物标志物。
T8153	glycohyodeoxycholic acid	Others; Endogenous Metabolite	Metabolism; Others
	Glycohyodeoxycholic acid 是一种人体次级胆汁酸猪去氧胆酸的主要代谢物，能够预防胆结石的形成。
T8192	Pentacosanoic acid	Others; Endogenous Metabolite	Metabolism; Others
	Pentacosanoic acid 是戊酸的共轭酸，是 25 碳长链饱和脂肪酸。
T5S0246	Pseudoprotodioscin 山药	Others; Fatty Acid Synthase	Metabolism; Others
	Pseudoprotodioscin 是一种呋喃葡糖苷，抑制SREBP1/2和microRNA 33a/b 水平，降低胆固醇和甘油三酯合成相关的基因表达。
TMS2180	Zeaxanthin Anchovyxanthin,All-Trans-Zeaxanthin,玉米	Antioxidant; Endogenous Metabolite	Metabolism; oxidation-reduction
	Zeaxanthin (All-Trans-Zeaxanthin) 是食物获得类胡萝卜素，存在于眼睛的黄斑部，具有抗氧化活性。
T2963	Cholic Acid Cholanic acid,胆汁酸,Cholate,Colalin	Endogenous Metabolite	Metabolism
	Cholic Acid (Cholate) 是肝脏产生的主要胆汁酸，与牛磺酸或甘氨酸缀合，有助于脂肪吸收和胆固醇排泄。
TN2082	Pinostrobin	Beta Amyloid; IL Receptor; Serine/threonin kinase; TNF	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation; Metabolism; Neuroscience
	Pinostrobin 是一种 PCSK9抑制剂，可抑制 PCSK9 的催化活性。它是能够在多种植物中发现的黄酮类化合物，并具有抗氧化，抗炎，抗癌和神经保护作用。它是有前景的胆固醇调节和脂质管理剂。
T2744	Methyl Cholate 胆酸甲酯,Cholic acid methyl ester	Others	Others
	Methyl Cholate (Cholic acid methyl ester) 是胆酸的甲酯形式。其中胆酸是一种由肝脏产生的主要胆汁酸，由胆固醇合成。
T4537	Cholic acid sodium 胆酸钠,[胆酸钠],SodiumCholate	HIV Protease; Endogenous Metabolite	Metabolism; Microbiology/Virology; Proteases/Proteasome
	Cholic acid sodium (SodiumCholate) 是肝脏中产生的主要胆汁酸，通常与牛磺酸或甘氨酸结合，有助于脂肪吸收和胆固醇排泄。
T4970	LANOSTEROL 羊毛甾醇,3β-Hydroxy-8,24-lanostadiene,8,24-Lanostadien-3β-ol	Endogenous Metabolite	Metabolism
	Lanosterol (3β-Hydroxy-8,24-lanostadiene) 是胆固醇合成的中间产物，能够诱导胆固醇合成的速率控制酶 HMG-CoA 还原酶的泛素化和降解。Lanosterol 可以抑制神经退行性疾病相关错误折叠蛋白的聚集和细胞毒性。
T0687	Simvastatin 辛伐他汀,MK-0733,MK 733	Apoptosis; Mitophagy; Ferroptosis; HMG-CoA Reductase; Autophagy	Apoptosis; Autophagy; Metabolism
	Simvastatin (MK 733) 是一种 HMG-CoA 还原酶抑制剂 (Ki=0.2 nM)，具有口服活性。Simvastatin 具有降血脂活性，可以抑制肝脏产生胆固醇，还可以用于预防心血管疾病。
T13522	7-Ketolithocholic acid 3α-Hydroxy-7-oxo-5β-cholanic acid	Endogenous Metabolite	Metabolism
	7-Ketolithocholic acid (3α-Hydroxy-7-oxo-5β-cholanic acid) (3α-Hydroxy-7-oxo-5β-cholanic acid) is capable of absorption and serves to suppress the production of endogenous bile acid and the secretion of biliary cholesterol.
TN6714	Geranylgeraniol FT-0626663,Tetraprenol,CJ24095,CJ 24095,FT0626663,香叶基香叶醇,CJ-24095	Apoptosis	Apoptosis
	Geranylgeraniol (FT0626663) 是一种类异戊二烯，存在于水果、蔬菜和谷物中，包括大米。 Geranylgeraniol (FT0626663) 抑制生长并诱导各种肿瘤细胞的凋亡。 Geranylgeraniol (FT0626663) 保护单核细胞免受他汀类药物诱导的细胞毒性并抑制分枝杆菌的生长。
TN6715	7-Ketocholesterol	Others	Others
	7-Ketocholesterol 是胆固醇的代谢物。
T4717	25-Hydroxycholesterol 25-羟基胆固醇,25-羟基胆甾醇	Others; Endogenous Metabolite; HMG-CoA Reductase	Metabolism; Others
	25-Hydroxycholesterol 是胆固醇的代谢产物，由巨噬细胞响应 Toll 样受体激活而分泌。它有效抑制 B 细胞产生 IgA，EC50约为 65 nM。
T4923	7-Dehydrocholesterol Provitamin D3,7-DHC,7-去氢胆固醇	Endogenous Metabolite	Metabolism
	7-Dehydrocholesterol (Provitamin D3) 是合成胆固醇和维生素 D3的前体。7-Dehydrocholesterol 下调培养的 Smith-Lemi-Opitz 综合征皮肤成纤维细胞中的胆固醇生物合成。
T10085	20(S)-Hydroxycholesterol 20α-Hydroxycholesterol	Smo	Stem Cells
	20(S)-Hydroxycholesterol (20α-Hydroxycholesterol) 是平滑 (smo) 癌蛋白的变构激活剂。
T10086	24-Hydroxycholesterol Cholest-5-ene-3beta,24-diol	Liver X Receptor; NMDAR	Metabolism; Neuroscience
	24-Hydroxycholesterol (Cholest-5-ene-3beta,24-diol) 是一种氧甾醇化合物，是一种 n-甲基-d-天门冬氨酸受体 (NMDA) 和转录因子 LXR 的激活剂，可用于研究心血管生成和胰腺癌。
T29329	24-Methylenecholesterol 24Methylenecholesterol,24 Methylenecholesterol,Chalinasterol,24-亚甲基胆固醇,Ostreasterol	Acyltransferase	Metabolism
	24-Methylenecholesterol (24 Methylenecholesterol) 是一种天然海洋甾醇，可刺激人类巨噬细胞中的胆固醇酰基转移酶 (ACAT))。
T14063	7α,25-Dihydroxycholesterol 7α,25-OHC	EBI2/GPR183; Endogenous Metabolite	GPCR/G Protein; Metabolism
	7α,25-Dihydroxycholesterol 是一种孤儿 GPCR 受体EBI2 (GPR183)的内源性配体和有效选择性激动剂。它对激活 EBI2 有很强的作用 (EC50=140 pM;Kd=450 pM)。它能够作为一种趋化因子，指导 B 细胞、T 细胞和树突状细胞的迁移。
T75515	7β,25-Dihydroxycholesterol
	7β,25-Dihydroxycholesterol 是一种内源性代谢物，被发现作为表达 EBI2 的免疫细胞的趋化剂。
TN1338	7Beta-Hydroxycholesterol	LDL; Calcium Channel; MAPK	MAPK; Membrane transporter/Ion channel; Metabolism
	7beta-Hydroxycholesterol, a major cytotoxin in oxidized LDL, induces Ca(2+) oscillations, MAP kinase activation and apoptosis in human aortic smooth muscle cells.
T19164	8-Dehydrocholesterol	Others	Others
	8-Dehydrocholesterol is a compound whose elevated concentration is a diagnostic biochemical hallmark of classical Smith-Lemli-Opitz syndrome.
T15720	Lathosterol	Endogenous Metabolite	Metabolism
	Lathosterol 是胆固醇样分子，其血清浓度是全身胆固醇合成的指标。
T5074	Cholesteryl palmitate	Others; Endogenous Metabolite	Metabolism; Others
	Cholesteryl palmitate 是一种慢性间质性肺炎的有用预后生物标志物。
T21383	D-Thyroxine Dethyrona,Detyroxin,Dextroid,Dextrothyroxine;Biotirmone,Dextroxin,Biotirmone,Debetrol,Dextrothyroxine	Others	Others
	D-Thyroxine (Dextroxin) 是一种甲状腺激素，对 TSH 的分泌具有抑制作用，可用于研究高胆固醇血症。
TN1474	Caulilexin C 板蓝根,1-甲氧基-3-吲哚乙腈	Others; Antifungal	Microbiology/Virology; Others
	Caulilexin C 是一种来自十字花科植物的植物抗毒素，具有抗真菌活性。
T4S2157	Campesterol 菜油甾醇,(24R)-5-Ergosten-3β-ol	Endogenous Metabolite	Metabolism
	Campesterol ((24R)-5-Ergosten-3β-ol) 是一种植物甾醇，具有降胆固醇和抗癌的活性。
T1207	Lovastatin MK-803,洛伐他汀,Mevinolin	Ferroptosis; HMG-CoA Reductase; Autophagy	Apoptosis; Autophagy; Metabolism
	Lovastatin (MK-803) 是一种 HMG-CoA 还原酶抑制剂，用于降低胆固醇。
T3771	Methyl protodioscin 山药,Smilax saponin B,NSC-698790	Apoptosis	Apoptosis
	Methyl protodioscin (Smilax saponin B) 是一种甾二糖苷，能诱导细胞周期阻滞，具有抗肿瘤活性。
T1664	Meglutol Dicrotalic acid,3-Hydroxy-3-methylglutaric acid,美格鲁托	Endogenous Metabolite; HMG-CoA Reductase; Autophagy	Autophagy; Metabolism
	Meglutol (3-Hydroxy-3-methylglutaric acid) 是一种抗血脂剂，可降低胆固醇、甘油三酯、血清 β-脂蛋白和磷脂。它抑制胆固醇生物合成中的限速酶羟甲基戊二酰辅酶 A 还原酶的活性。
T19711	Desmosterol Desmesterol,24-Dehydrocholesterol	Endogenous Metabolite	Metabolism
	Desmosterol(24-Dehydrocholesterol) 是一种胆固醇生物合成中间体，抑制巨噬细胞炎症小体活化，防止血管炎症和动脉粥样硬化。
T5238	1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine 1,2-Dipalmitoyl-sn-glycero-3-PE,L-磷脂酰乙醇胺,1,2-Dipalmitoyl-sn-glycerol-3-Phosphoethanolamine,1,2-DPPE	Others; Endogenous Metabolite	Metabolism; Others
	1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine (DPPE) 是内源性代谢产物的一种。
T2962	5α-Cholestan-3β-ol Dihydrocholesterol,Zymostanol,5α-Cholestanol,5alpha-Cholestanol,NSC 18188,Beta-Cholestanol,二氢胆甾醇	Others; Endogenous Metabolite	Metabolism; Others
	5α-Cholestan-3β-ol (NSC 18188) 是衍生化的类固醇化合物的一种。
T5544	2-Furoic acid Furan-2-carboxylic acid,糠酸	Anti-infection; ATP Citrate Lyase; Endogenous Metabolite; Acyltransferase	Metabolism; Microbiology/Virology
	2-Furoic acid (Furan-2-carboxylic acid) 2-Furoic acid 能够降低血清中胆固醇和甘油三酯的水平，具有抗血脂作用。
T8165	Erythrodiol	Endogenous Metabolite; ABC	Membrane transporter/Ion channel; Metabolism
	Erythrodiol 是一种橄榄油的成分，能够选择性抑制ABCA1蛋白的降解来促进胆固醇外流，有用于动脉粥样硬化的研究潜力。
T0254	Probucol DH-581,普罗布考	Virus Protease; ABC; Lipid	Membrane transporter/Ion channel; Metabolism; Microbiology/Virology
	Probucol (DH-581) 是一种抗高脂血症药物，可通过增加 LDL 分解代谢率来降低血液中的胆固醇水平。
T19085	1-Palmitoyl-2-oleoyl-sn-glycero-3-PC POPC,2-油酰-1-棕榈锡甘油-3-磷酸胆碱,1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine,Palmitoyloleoylphosphatidylcholine	Others	Others
	1-Palmitoyl-2-oleoyl-sn-glycero-3-PC (Palmitoyloleoylphosphatidylcholine) 是生物膜的主要成分，是一种磷脂。它用于脂质体的制备以及脂质双层的特性的研究。
T3761	1-Octacosanol n-Octacosanol,二十八烷醇,Montanyl alcohol,Cluytyl alcohol,Octacosanol,Octacosyl alcohol,Octanosol	Others	Others
	1-Octacosanol (Octanosol) 是直链脂肪族 28 碳脂肪醇，具有抗疲劳作用。
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天然产物

Cat.No: T0760

Synonym: Cholesterin,Cholesteryl alcohol,胆固醇

Target: Estrogen Receptor/ERR, MRP, Endogenous Metabolite, ROR

Cholesterol myristate

Cat.No: T8040

Synonym: 胆甾烯基豆蔻酸酯,Cholesteryl myristate,胆固醇肉豆蔻酸,Cholesteryl tetradecanoate

Target: Others, Potassium Channel, GABA Receptor, Endogenous Metabolite, AChR

Cholesteryl Acetate

Cat.No: T2918

Synonym: Cholesterin acetate,胆甾醇乙酸酯,Cholesterol acetate,Acebrochol

Target: Others

Cholesterol glucuronide

Cat.No: T10805

Target: Others

Cholesteryl oleate

Cat.No: T19237

Synonym: 胆固醇油酸酯,Oleoylcholesterol,Cholesterol Oleate,Cholesteryl cis-9-octadecenoate

Target: Endogenous Metabolite

27-Hydroxycholesterol

Cat.No: TQ0274

Synonym: 27-羟基胆固醇,5,25R-胆甾烯-3BETA,26-二醇,25(R)-27-hydroxy Cholesterol

Target: Estrogen/progestogen Receptor, Liver X Receptor

Cholesteryl sulfate sodium

Cat.No: T5239

Synonym: Cholesterol 3-Sulfate Sodium Salt,胆固醇硫酸酯钠盐,Sodium Cholesteryl Sulfate

Target: Endogenous Metabolite, PKC

Cholesteryl linoleate

Cat.No: T5214

Synonym: CE(18:2(9Z,12Z)),Cholesterol Linoleate,Linoleic Acid cholesteryl ester,胆甾烯基亚油酸酯

Target: Others, Endogenous Metabolite

Cholesteryl behenate

Cat.No: T19236

Synonym: Cholesteryl docosanoate,Cholesterol behenate,胆固醇山萮酸酯

Target: Others

Cat.No: T2721

Target: Others

Diallyl disulfide

Cat.No: TN1576

Target: IL Receptor, NOS, NF-κB

7α-Hydroxycholesterol

Cat.No: T19161

Target: Others

glycohyodeoxycholic acid

Cat.No: T8153

Target: Others, Endogenous Metabolite

Pentacosanoic acid

Cat.No: T8192

Target: Others, Endogenous Metabolite

Pseudoprotodioscin

Cat.No: T5S0246

Synonym: 山药

Target: Others, Fatty Acid Synthase

Cat.No: TMS2180

Synonym: Anchovyxanthin,All-Trans-Zeaxanthin,玉米

Target: Antioxidant, Endogenous Metabolite

Cat.No: T2963

Synonym: Cholanic acid,胆汁酸,Cholate,Colalin

Target: Endogenous Metabolite

Cat.No: TN2082

Target: Beta Amyloid, IL Receptor, Serine/threonin kinase, TNF

Cat.No: T2744

Synonym: 胆酸甲酯,Cholic acid methyl ester

Target: Others

Cholic acid sodium

Cat.No: T4537

Synonym: 胆酸钠,[胆酸钠],SodiumCholate

Target: HIV Protease, Endogenous Metabolite

Cat.No: T4970

Synonym: 羊毛甾醇,3β-Hydroxy-8,24-lanostadiene,8,24-Lanostadien-3β-ol

Target: Endogenous Metabolite

Cat.No: T0687

Synonym: 辛伐他汀,MK-0733,MK 733

Target: Apoptosis, Mitophagy, Ferroptosis, HMG-CoA Reductase, Autophagy

7-Ketolithocholic acid

Cat.No: T13522

Synonym: 3α-Hydroxy-7-oxo-5β-cholanic acid

Target: Endogenous Metabolite

Geranylgeraniol

Cat.No: TN6714

Synonym: FT-0626663,Tetraprenol,CJ24095,CJ 24095,FT0626663,香叶基香叶醇,CJ-24095

Target: Apoptosis

7-Ketocholesterol

Cat.No: TN6715

Target: Others

25-Hydroxycholesterol

Cat.No: T4717

Synonym: 25-羟基胆固醇,25-羟基胆甾醇

Target: Others, Endogenous Metabolite, HMG-CoA Reductase

7-Dehydrocholesterol

Cat.No: T4923

Synonym: Provitamin D3,7-DHC,7-去氢胆固醇

Target: Endogenous Metabolite

20(S)-Hydroxycholesterol

Cat.No: T10085

Synonym: 20α-Hydroxycholesterol

Target: Smo

24-Hydroxycholesterol

Cat.No: T10086

Synonym: Cholest-5-ene-3beta,24-diol

Target: Liver X Receptor, NMDAR

24-Methylenecholesterol

Cat.No: T29329

Synonym: 24Methylenecholesterol,24 Methylenecholesterol,Chalinasterol,24-亚甲基胆固醇,Ostreasterol

Target: Acyltransferase

7α,25-Dihydroxycholesterol

Cat.No: T14063

Synonym: 7α,25-OHC

Target: EBI2/GPR183, Endogenous Metabolite

7β,25-Dihydroxycholesterol

Cat.No: T75515

7Beta-Hydroxycholesterol

Cat.No: TN1338

Target: LDL, Calcium Channel, MAPK

8-Dehydrocholesterol

Cat.No: T19164

Target: Others

Cat.No: T15720

Target: Endogenous Metabolite

Cholesteryl palmitate

Cat.No: T5074

Target: Others, Endogenous Metabolite

Cat.No: T21383

Synonym: Dethyrona,Detyroxin,Dextroid,Dextrothyroxine;Biotirmone,Dextroxin,Biotirmone,Debetrol,Dextrothyroxine

Target: Others

Cat.No: TN1474

Synonym: 板蓝根,1-甲氧基-3-吲哚乙腈

Target: Others, Antifungal

Cat.No: T4S2157

Synonym: 菜油甾醇,(24R)-5-Ergosten-3β-ol

Target: Endogenous Metabolite

Cat.No: T1207

Synonym: MK-803,洛伐他汀,Mevinolin

Target: Ferroptosis, HMG-CoA Reductase, Autophagy

Methyl protodioscin

Cat.No: T3771

Synonym: 山药,Smilax saponin B,NSC-698790

Target: Apoptosis

Cat.No: T1664

Synonym: Dicrotalic acid,3-Hydroxy-3-methylglutaric acid,美格鲁托

Target: Endogenous Metabolite, HMG-CoA Reductase, Autophagy

Cat.No: T19711

Synonym: Desmesterol,24-Dehydrocholesterol

Target: Endogenous Metabolite

1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine

Cat.No: T5238

Synonym: 1,2-Dipalmitoyl-sn-glycero-3-PE,L-磷脂酰乙醇胺,1,2-Dipalmitoyl-sn-glycerol-3-Phosphoethanolamine,1,2-DPPE

Target: Others, Endogenous Metabolite

5α-Cholestan-3β-ol

Cat.No: T2962

Synonym: Dihydrocholesterol,Zymostanol,5α-Cholestanol,5alpha-Cholestanol,NSC 18188,Beta-Cholestanol,二氢胆甾醇

Target: Others, Endogenous Metabolite

Cat.No: T5544

Synonym: Furan-2-carboxylic acid,糠酸

Target: Anti-infection, ATP Citrate Lyase, Endogenous Metabolite, Acyltransferase

Cat.No: T8165

Target: Endogenous Metabolite, ABC

Cat.No: T0254

Synonym: DH-581,普罗布考

Target: Virus Protease, ABC, Lipid

1-Palmitoyl-2-oleoyl-sn-glycero-3-PC

Cat.No: T19085

Synonym: POPC,2-油酰-1-棕榈锡甘油-3-磷酸胆碱,1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine,Palmitoyloleoylphosphatidylcholine

Target: Others

Cat.No: T3761

Synonym: n-Octacosanol,二十八烷醇,Montanyl alcohol,Cluytyl alcohol,Octacosanol,Octacosyl alcohol,Octanosol

Target: Others

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