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Search Results for " anti-hiv "

100

抑制剂 & 化合物

76

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T28578	Ro24-7429 Ro 24-7429,Ro-24-7429,Ro 247429	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Ro24-7429 是一种有效的口服活性 HIV-1 反式激活蛋白 Tat 拮抗剂和一种矮小相关转录因子 1 的抑制剂。Ro24-7429 具有抗 HIV、抗纤维化和抗炎作用。
T3199	PTACH NCH-51,Cpd 51	HIV Protease; HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair; Microbiology/Virology; Proteases/Proteasome
	PTACH (Cpd 51) 是一种有效的 HDAC 抑制剂，对 HDAC1，HDAC4和 HDAC6的 IC50分别为 48 nM，32 nM 和 41 nM。PTACH 对多种癌细胞具有强大的生长抑制作用 (EC50为 1.1-9.1 µM)。
T11538	Hck-IN-1	HIV Protease; Src; Hck	Angiogenesis; Microbiology/Virology; Proteases/Proteasome; Tyrosine Kinase/Adaptors
	Hck-IN-1 是二苯基吡唑啉化合物，选择性的 Nef 依赖性 Hck 抑制剂。它是广泛的 HIV-1 Nef 直接拮抗剂，对于野生型 HIV-1 复制的IC50为 100-300 nM。它结合口袋残基 Asn126，具有抗逆转录病毒活性。
T11465	Lenacapavir GS-6207	Others; HIV Protease	Microbiology/Virology; Others; Proteases/Proteasome
	Lenacapavir (GS-6207) 是一种有效的靶向衣壳的 HIV 复制抑制剂。 Lenacapavir 在 MT-4 细胞中显示出抗 HIV 活性，EC50 为 100 pM。
T20489	Benzalphthalide NSC2824,NSC-2824,亚苄基酞,NSC 2824	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Benzalphthalide (NSC-2824) 是一种具有抗 HIV 活性的化合物。
T2239L	Raltegravir 雷特格韦,MK-0518	HIV Protease; Integrase	Microbiology/Virology; Proteases/Proteasome
	Raltegravir (MK-0518) 是一种HIV 整合酶抑制剂。
T68156	(Rac)-Telinavir	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	(Rac)-Telinavir 具有抗 HIV 活性。
T6256	YYA-021 YYA 021	gp120/CD4; HIV Protease	Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome
	YYA-021具有高抗HIV 活性和低细胞毒性，是一种抑制HIV 进入的小分子CD4模拟物,。
TQ0297	Cenicriviroc TAK-652,TBR-652	HIV Protease; CCR	Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome
	Cenicriviroc (TAK-652) 是一种可口服的CCR2/CCR5拮抗剂，可抑制 HIV-1 和 HIV-2，具有抗炎、抗感染作用。
T15210	Elsulfavirine Elpida,VM-1500	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Elsulfavirine (VM-1500) 是一种 HIV-1 感染的逆转录酶抑制剂，也是抗 HIV 的新药。
T71665	INCB-9471	HIV Protease; CCR	Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome
	INCB-9471 是一种 CCR5 拮抗剂，具有抗HIV活性，抑制 HIV-1 gp120 之间的相互作用。
T10111	3-Deazaadenosine hydrochloride	Others; HIV Protease	Microbiology/Virology; Others; Proteases/Proteasome
	3-Deazaadenosine hydrochloride 是 S-腺苷高半胱氨酸水解酶的抑制剂，Ki 值为 3.9 µM。它具有抗炎、抗增殖和抗 HIV 活性。
T77059	Leronlimab PRO 140	CCR	Immunology/Inflammation; Microbiology/Virology
	Leronlimab (PRO 140) 是一种人源化 IgG4 抗 CCR5 单克隆抗体。leronlimumab 具有抗 HIV 病毒活性和抗肿瘤活性，抑制 CCR 介导的 HIV-1 病毒和小鼠肿瘤模型中癌细胞转移。Leronlimab 可用于研究 HIV 非酒精性脂肪性肝炎 (NASH) 和乳腺癌。
T7624	DAPTA DAPTA(TFA),D-Ala-peptide T-amide,Adaptavir	HIV Protease; CCR	Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome
	DAPTA (Adaptavir) 是一种合成肽，是 CCR5抑制剂，有抗 HIV 的活性。
T22565	AMD-070 hydrochloride N-(1H-苯并咪唑-2-基甲基)-N-[(8S)-5,6,7,8-四氢-8-喹啉基]-1,4-丁二胺单盐酸盐	CXCR	Autophagy; GPCR/G Protein; Immunology/Inflammation
	AMD-070 hydrochloride 是一种 CXCR4 拮抗剂，可用于抗 HIV。
T8311	Obefazimod ABX-464,ABX464	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Obefazimod (ABX-464) 是一种抗HIV 剂。它抑制受刺激的外周血单核细胞中的 HIV-1 复制，IC50值为 0.1 μM 至 0.5 μM。
T9942	WAY-639418	HIV Protease; CCR	Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome
	WAY-639418 具有潜在的抗炎和抗 HIV 活性，可用于研究 CCR5 介导的炎症和免疫调节性疾病。
TP1149	HIV-1 Rev (34-50) HIV-1 Rev 34-50,HIV-1 rev Protein (34-50)	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	HIV-1 Rev (34-50) (HIV-1 rev Protein (34-50)) 是一种具有抗 HIV-1 活性的 17 个氨基酸多肽。 HIV-1 Rev (34-50) 源自 HIV-1 中 Rev 的 Rev 响应元件结合域。
T16098	Islatravir MK-8591	HIV Protease; Reverse Transcriptase	Microbiology/Virology; Proteases/Proteasome
	Islatravir (MK-8591) 是一种核苷逆转录酶抑制剂，是抗HIV-1药物，对 HIV-1 (WT)，HIV-1 (M184V)，HIV-1 (MDR) 的EC50值分别为 0.068 nM，3.1 nM 和 0.15 nM。
T67833	HIV-1 inhibitor-54	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	HIV-1 inhibitor-54 是一种有效的 HIV-1 抑制剂，在 MT-4 细胞中对 WT HIV-1 (菌株 IIIB) x 显示出抗 HIV 活性（EC50 ： 32 nM）。HIV-1 inhibitor-54 可用于研究病毒感染。
T0100	Atazanavir sulfate 阿扎那韦硫酸盐,BMS-232632,BMS-232632 sulfate,硫酸阿扎那韦	P450; SARS-CoV; HIV Protease; P-gp	Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience; Proteases/Proteasome
	Atazanavir sulfate (BMS-232632 sulfate) 是一种氮杂肽和 HIV 蛋白酶抑制剂，与其他抗 HIV 药物联合用于治疗 HIV 感染和艾滋病。它也是SARS-CoV 3CLpro 抑制剂，IC50为 3.49 μM。
T7208	AMD 3465 hexahydrobromide GENZ-644494 (hexahydrobromide)	HIV Protease; CXCR	Autophagy; GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome
	AMD 3465 hexahydrobromide (GENZ-644494 (hexahydrobromide)) 是一种 CXCR4受体拮抗剂，具有潜在的抗癌和抗 HIV 活性。
T67737	gp120-α4β7 binding inhibitor 11	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	gp120-α4β7 binding inhibitor 11是一种抗HIV 药物。gp120-α4β7 binding inhibitor 11干扰HIV 相关糖蛋白gp12G 与整合素α4β7的结合（IC50=1.64nM）。
T41249	Tenofovir alafenamide fumarate GS-7340 fumarate	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Tenofovir alafenamide fumarate (GS-7340 fumarate) 是一种可口服的 Tenofovir 前体化合物。Tenofovir alafenamide fumarate 具有抗 HIV 活性，可用于预防 HIV 感染。
T3335	Darunavir Ethanolate 地瑞那韦乙醇盐,UIC 94017,Darunavir Ethanolate,TMC114,达芦那韦乙醇	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Darunavir Ethanolate (UIC 94017) 是一种HIV 蛋白酶抑制剂，可以用于 HIV/AIDS 的相关研究。对野生型 HIV-1 蛋白酶的Ki 值为1 nM。
T61793	HIV-IN-6	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	HIV-IN-6 是一种 HIV 病毒抑制剂，可抑制HIV 病毒的复制。HIV-IN-6 具有抗HIV 病毒的活性，通过靶向与病毒 Nef 蛋白相互作用的 Src 家族激酶 (SFK) (如 Hck) 而起作用。
T22021	ACHP IKK-2 Inhibitor VIII	IκB/IKK	NF-κB
	ACHP(IKK-2 Inhibitor VIII) 是一种新型具有选择性和高效性的 IKK 抑制剂，对IKK-α和IKK-β 具有抑制作用。ACHP 具有抗 HIV-1 活性，通过抑制 NF-κB 激活来抑制 HIV-1 长末端重复序列（LTR）驱动的基因表达，抑制 TNF-α 诱导的 NF-κB （p65）募集到 HIV-1 LTR。
T8238	Fosamprenavir Calcium Salt 福沙那伟钙,Diallyl Trisulfide,GW433908G	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Fosamprenavir Calcium Salt (GW433908G) 是抗逆转录病毒蛋白酶抑制剂 Amprenavir 的磷酸酯前药，具有改善的溶解性和抗HIV 感染作用。
T2324	Darunavir 地瑞那韦,达芦那韦,TMC114	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Darunavir (TMC114) 是一种 HIV 蛋白酶抑制剂，用于治疗艾滋病和 HIV 感染。由于单独使用时会出现抗病毒药物耐药性，因此与其他抗 HIV 药物联合使用。
T35340	Bictegravir Sodium GS-9883 Sodium	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Bictegravir Sodium (GS-9883 Sodium) 是一种有效的 HIV-1 整合酶抑制剂，其 IC50 值为 7.5 nM。Bictegravir Sodium 表现出强大的选择性的抗 HIV 活性和低的细胞毒性。
T72910	APOBEC3G-IN-1	Others	Others
	APOBEC3G-IN-1 (MN136.0185) 是一种靶向 APOBEC3G 抑制剂，具有抗 HIV 活性，可用于研究传染病和癌症。
T76687	Ibalizumab TNX-355,TMB-355	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Ibalizumab(TMB-355) 是一种人源化 IgG4 单克隆抗体，可作为 CD4 受体抑制，通过与 CD4 受体结合来阻止 HIV-1进入细胞。Ibalizumab 具有抗HIV-1感染活性，可用于维持机体正常免疫功能。
T31860	Fosdevirine GSK-2248761A,IDX 899,GSK 2248761A,GSK 2248761,GSK-2248761,IDX-12899,GSK2248761,FDV,GSK2248761A	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Fosdevirine (GSK2248761) 是一种具有选择性和高效性的非核苷类逆转录酶 (NNRTI) 抑制剂，具有抗 HIV 活性，可用于研究迟发性癫痫等神经系统相关疾病。
T6246	Cobicistat Tybost,GS-9350,考西司他	P450; HIV Protease	Metabolism; Microbiology/Virology; Proteases/Proteasome
	Cobicistat (GS-9350) 是一种细胞色素酶P450 3A 的选择性抑制剂，IC50值为30-285 nM。它是一种药代动力学增强剂，可增强抗 HIV 药物的吸收。
TP1348	FC131 TFA (606968-52-9 free base) FC131 TFA	HIV Protease; CXCR	Autophagy; GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome
	FC131 TFA (606968-52-9 free base) (FC131 TFA) 是 CXCR4 的拮抗剂，可抑制 [125I] -sdf-1 与 CXCR4 的结合（IC50：4.5 nM），并具有抗 HIV 活性。
T31860L	(Iso)-Fosdevirine (Iso)-Fosdevirine（Iso-1018450-26-4）,(Iso)-GSK2248761	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	(Iso)-Fosdevirine ( (Iso)-GSK2248761) 是一种具有选择性和高效性的非核苷类逆转录酶 (NNRTI) 抑制剂，具有抗 HIV 活性，可用于研究迟发性癫痫等神经系统相关疾病。
T67797	DDG-39 1-(2,3-dideoxy-2-fluoropentofuranosyl)cytosine	Antiviral; HBV; HIV Protease	Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome
	DDG-39 (1-(2,3-dideoxy-2-fluoropentofuranosyl)cytosine)具有抗病毒活性，在细胞培养中具有有效的选择性抗 HIV-1 和HBV 活性。平均抗病毒 IC50为0.61μM。
TP2112L	TC14012 acetate TC14012 acetate(368874-34-4 free base)	CXCR; Arrestin	Autophagy; GPCR/G Protein; Immunology/Inflammation
	TC14012 acetate 是 T140 的血清稳定衍生物，是一种选择性的肽模拟 CXCR4 拮抗剂，IC50 为 19.3 nM。 TC14012 还是一种有效的 CXCR7 激动剂，EC50 为 350 nM，可将 β-arrestin 2 募集到 CXCR7。 TC14012 具有抗癌活性和抗 HIV 活性。
T21746	Terameprocol tetramethyl Nordihydroguaiaretic Acid,EM-1421	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Terameprocol (EM-1421) 是 Nordihydroguaiaretic acid 的合成衍生物，是非选择性脂氧合酶抑制剂。
T38514	PMEDAP	Others; HIV Protease	Microbiology/Virology; Others; Proteases/Proteasome
	PMEDAP 是有效的人类免疫缺陷病毒 (HIV) 复制抑制剂。它具有抗小鼠巨细胞病毒活性。它有效抑制莫罗尼鼠肉瘤病毒诱导的肿瘤形成和相关死亡率。
T60540	Netivudine
	Netivudine 是一种有效的核苷类逆转录酶抑制剂(NRTIs)，是一种核苷类似物，具有抗水痘带状疱疹病毒活性，可用于治疗人类免疫缺陷病毒(HIV)感染。Netivudine 通过抑制逆转录酶起作用，通过抑制作用减少体内的病毒载量，减缓疾病的进展。
T0781	Dimercaprol Dicaptol,二巯丙醇,Dithiopropanol,二巯基丙醇	Others; HIV Protease	Microbiology/Virology; Others; Proteases/Proteasome
	Dimercaprol (Dicaptol) 是一种具有抗HIV 活性的重金属中毒解毒剂。
T35617	Mitoguazone MGBG,Methyl-GAG	Apoptosis; HIV Protease	Apoptosis; Microbiology/Virology; Proteases/Proteasome
	Mitoguazone (Methyl-GAG) 是一种可透过血脑屏障的选择性的 S-腺苷-蛋氨酸脱羧酶 (S-adenosyl-methionine decarboxylase) 抑制剂，可破坏多胺的生物合成。Mitoguazone 是一种具有抗肿瘤活性的合成多羰基衍生物，可抑制 HIV DNA 整合到单核细胞和巨噬细胞中的细胞 DNA 中，诱导细胞凋亡 (apoptosis)。Mitoguazone 具可用于预防急性白血病，霍奇金淋巴瘤和非霍奇金淋巴瘤。
T0825	Ebselen SPI-1005,PZ-51,依布硒,CCG-39161	Phosphatase; Virus Protease; Calcium Channel; COX; HIV Protease	Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience; Proteases/Proteasome
	Ebselen (CCG-39161) 是一种谷胱甘肽过氧化物酶模拟物，是电压依赖性钙通道阻断剂。它抑制Mpro 和COVID-19病毒，是HIV-1衣壳 CTD 二聚化的抑制剂，具有抗炎、抗癌和抗氧化活性。
T26234	Suberosol
	Suberosol possesses anti-HIV replication activity.
T24139	Hinnuliquinone L 767827,L767827,L-767827
	Hinnuliquinone is an anti-HIV agent.
T11566	HIV-1 integrase inhibitor	Others	Others
	Hiv-1 integrase inhibitor is an effective anti-HIV drug.
T26434	A 69992 A-69992,Abbott 69992,A-75962,A 75962,A69992
	A 69992 is an HIV anti-infective nucleoside.
T29217	ZINC04177596
	ZINC04177596 is a novel Nef Protein Inhibitor with anti-HIV activity.
T15739	Letrazuril	Others	Others
	Letrazuril is a compound of the anti-HIV.

化合物

Cat.No: T28578

Synonym: Ro 24-7429,Ro-24-7429,Ro 247429

Target: HIV Protease

Cat.No: T3199

Synonym: NCH-51,Cpd 51

Target: HIV Protease, HDAC

Cat.No: T11538

Target: HIV Protease, Src, Hck

Cat.No: T11465

Synonym: GS-6207

Target: Others, HIV Protease

Benzalphthalide

Cat.No: T20489

Synonym: NSC2824,NSC-2824,亚苄基酞,NSC 2824

Target: HIV Protease

Cat.No: T2239L

Synonym: 雷特格韦,MK-0518

Target: HIV Protease, Integrase

(Rac)-Telinavir

Cat.No: T68156

Target: HIV Protease

Cat.No: T6256

Synonym: YYA 021

Target: gp120/CD4, HIV Protease

Cat.No: TQ0297

Synonym: TAK-652,TBR-652

Target: HIV Protease, CCR

Cat.No: T15210

Synonym: Elpida,VM-1500

Target: HIV Protease

Cat.No: T71665

Target: HIV Protease, CCR

3-Deazaadenosine hydrochloride

Cat.No: T10111

Target: Others, HIV Protease

Cat.No: T77059

Synonym: PRO 140

Target: CCR

Cat.No: T7624

Synonym: DAPTA(TFA),D-Ala-peptide T-amide,Adaptavir

Target: HIV Protease, CCR

AMD-070 hydrochloride

Cat.No: T22565

Synonym: N-(1H-苯并咪唑-2-基甲基)-N-[(8S)-5,6,7,8-四氢-8-喹啉基]-1,4-丁二胺单盐酸盐

Target: CXCR

Cat.No: T8311

Synonym: ABX-464,ABX464

Target: HIV Protease

Cat.No: T9942

Target: HIV Protease, CCR

HIV-1 Rev (34-50)

Cat.No: TP1149

Synonym: HIV-1 Rev 34-50,HIV-1 rev Protein (34-50)

Target: HIV Protease

Cat.No: T16098

Synonym: MK-8591

Target: HIV Protease, Reverse Transcriptase

HIV-1 inhibitor-54

Cat.No: T67833

Target: HIV Protease

Atazanavir sulfate

Cat.No: T0100

Synonym: 阿扎那韦硫酸盐,BMS-232632,BMS-232632 sulfate,硫酸阿扎那韦

Target: P450, SARS-CoV, HIV Protease, P-gp

AMD 3465 hexahydrobromide

Cat.No: T7208

Synonym: GENZ-644494 (hexahydrobromide)

Target: HIV Protease, CXCR

gp120-α4β7 binding inhibitor 11

Cat.No: T67737

Target: HIV Protease

Tenofovir alafenamide fumarate

Cat.No: T41249

Synonym: GS-7340 fumarate

Target: HIV Protease

Darunavir Ethanolate

Cat.No: T3335

Synonym: 地瑞那韦乙醇盐,UIC 94017,Darunavir Ethanolate,TMC114,达芦那韦乙醇

Target: HIV Protease

Cat.No: T61793

Target: HIV Protease

Cat.No: T22021

Synonym: IKK-2 Inhibitor VIII

Target: IκB/IKK

Fosamprenavir Calcium Salt

Cat.No: T8238

Synonym: 福沙那伟钙,Diallyl Trisulfide,GW433908G

Target: HIV Protease

Cat.No: T2324

Synonym: 地瑞那韦,达芦那韦,TMC114

Target: HIV Protease

Bictegravir Sodium

Cat.No: T35340

Synonym: GS-9883 Sodium

Target: HIV Protease

Cat.No: T72910

Target: Others

Cat.No: T76687

Synonym: TNX-355,TMB-355

Target: HIV Protease

Cat.No: T31860

Synonym: GSK-2248761A,IDX 899,GSK 2248761A,GSK 2248761,GSK-2248761,IDX-12899,GSK2248761,FDV,GSK2248761A

Target: HIV Protease

Cat.No: T6246

Synonym: Tybost,GS-9350,考西司他

Target: P450, HIV Protease

FC131 TFA (606968-52-9 free base)

Cat.No: TP1348

Synonym: FC131 TFA

Target: HIV Protease, CXCR

(Iso)-Fosdevirine

Cat.No: T31860L

Synonym: (Iso)-Fosdevirine（Iso-1018450-26-4）,(Iso)-GSK2248761

Target: HIV Protease

Cat.No: T67797

Synonym: 1-(2,3-dideoxy-2-fluoropentofuranosyl)cytosine

Target: Antiviral, HBV, HIV Protease

TC14012 acetate

Cat.No: TP2112L

Synonym: TC14012 acetate(368874-34-4 free base)

Target: CXCR, Arrestin

Cat.No: T21746

Synonym: tetramethyl Nordihydroguaiaretic Acid,EM-1421

Target: HIV Protease

Cat.No: T38514

Target: Others, HIV Protease

Cat.No: T60540

Cat.No: T0781

Synonym: Dicaptol,二巯丙醇,Dithiopropanol,二巯基丙醇

Target: Others, HIV Protease

Cat.No: T35617

Synonym: MGBG,Methyl-GAG

Target: Apoptosis, HIV Protease

Cat.No: T0825

Synonym: SPI-1005,PZ-51,依布硒,CCG-39161

Target: Phosphatase, Virus Protease, Calcium Channel, COX, HIV Protease

Cat.No: T26234

Cat.No: T24139

Synonym: L 767827,L767827,L-767827

HIV-1 integrase inhibitor

Cat.No: T11566

Target: Others

Cat.No: T26434

Synonym: A-69992,Abbott 69992,A-75962,A 75962,A69992

Cat.No: T29217

Cat.No: T15739

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
TN2283	Tripterifordin	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Tripterifordin 在 H9 淋巴细胞中显示出抗 HIV 复制活性，EC50值为 3100 nM。
T12651	Rabdosiin (+)-Rabdosiin	Others	Others
	Rabdosiin ((+)-Rabdosiin) 是一种分离自 Rabdosia japonicaHara 中的咖啡酸四聚体，具有抗过敏、抗 HIV 和抑制 DNA 拓扑异构酶作用。
T2S0731	Trilobatin 三叶苷,三叶甙,P-Phlorizin	Amylase	Metabolism
	Trilobatin (P-Phlorizin) 是源自Lithocarpus polystachyusRehd 的甜味剂，是一种HIV-1抑制剂，靶向 Gp41 包膜蛋白，具有神经保护作用。它还是SGLT1/2抑制剂，可选择性诱导人肝母细胞瘤细胞增殖。
T0492	Dimethyl fumarate 富马酸二甲酯,DMF	Reactive Oxygen Species; HIV Protease; Nrf2; Endogenous Metabolite; Autophagy	Autophagy; Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB; Proteases/Proteasome
	Dimethyl fumarate (DMF) 是具有口服活性且可透过血脑屏障的Nrf2激活剂，可诱导抗氧化剂基因表达上调。它是一种富马酸盐衍生物，可作抗炎和免疫调节剂，可研究多发性硬化症。
T0070	Pentoxifylline Oxpentifylline,PTX,己酮可可碱,BL-191	HIV Protease; PDE; Adenosine Receptor; Autophagy	Autophagy; GPCR/G Protein; Metabolism; Microbiology/Virology; Neuroscience; Proteases/Proteasome
	Pentoxifylline (PTX) 是一种具有口服活性的磷酸二酯酶非选择性抑制剂，具有免疫调节、抗炎、抗纤溶、抗增殖和血液流变学改善作用。它可研究周围血管疾病、脑血管疾病和其他一些涉及局部微循环缺陷的疾病。
T4S1387	Isoescin IA 七叶皂苷C,异七叶皂苷 IA	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Isoescin IA 是一种从七叶树种子中分离出来的三萜皂苷。它具有抗HIV-1蛋白酶活性。
T2775	Baicalin 黄芩苷,黄岑苷,Baicalein 7-O-β-D-glucuronide	NF-κB; HIV Protease; GABA Receptor; Autophagy	Autophagy; Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience; NF-κB; Proteases/Proteasome
	Baicalin (Baicalein 7-O-β-D-glucuronide) 是一种从黄芩中分离出来的脯氨酰内肽酶抑制剂，具有抗氧化、抗肿瘤、抗 HIV 的特性。
T3730	Methyl gallate NSC 363001,Gallicin,Gallic acid methyl ester,Gallincin,没食子酸甲酯	Reactive Oxygen Species; HIV Protease; Reverse Transcriptase; Antibacterial	Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB; Proteases/Proteasome
	Methyl gallate (Gallincin) 是具有抗氧化，抗癌和抗炎活性的植物酚类。它也可抑制细菌活性。它还具有抗HIV-1和HIV-1酶的抑制活性。
TQ0217	Gomisin G 戈米辛G,戈米辛 G	P450; HIV Protease	Metabolism; Microbiology/Virology; Proteases/Proteasome
	Gomisin G 是一种有抗HIV 活性的天然产物。
T5783	Rosamultin 野蔷薇苷,罗莎白素	Antioxidant; HIV Protease	Microbiology/Virology; oxidation-reduction; Proteases/Proteasome
	Rosamultin 是从Potentilla anserina L 分离的 19 α-羟基型三萜。它抑制 HIV-1 蛋白酶，具有抗氧化、抗炎和镇痛作用。
T3683	lithospermic acid	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Lithospermic acid 是一种植物来源的多环酚类羧酸，从丹参中分离得到，对 CCl4诱导的急性和体外肝损伤具有抗氧化和保肝活性。
T8689	Chloroquine CQ,氯喹	SARS-CoV; TLR; HIV Protease; Antibiotic; Parasite; Autophagy	Autophagy; Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome
	Chloroquine 是一种 Toll 样受体抑制剂，可以抑制自噬。Chloroquine 具有抗疟疾和抗炎活性，广泛用于治疗疟疾和类风湿性关节炎。Chloroquine 还具有抗 SARS-CoV-2 (COVID-19) 活性、抗 HIV-1 活性。
T4962	Zingibroside R1 Ginsenoside Z-R1,姜状三七皂苷R1,姜状三七苷R1	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Zingibroside R1 (Ginsenoside Z-R1) 是分离自Panax japonicasC. A. Meyer 根部的一种三萜皂苷，有HIV-1、抗肿瘤和抗血管生成活性。它对 EAT 细胞的 2-脱氧-D-葡萄糖的摄取具有抑制作用，IC50值为91.3 μM。
T8859	NITIDINE	Others	Others
	NITIDINE 是一种从花椒根中分离出来的具有生物活性的植物苯并菲啶生物碱。它具有抗癌、神经保护、抗疟疾、抗 HIV、镇痛、抗炎和抗真菌活性。
T2S1158	4,5-Dicaffeoylquinic acid 3,4-Dicaffeoylquinic acid,异绿原酸C(4,5),Isochlorogenic acid C	Others; HBV; Endogenous Metabolite	Metabolism; Microbiology/Virology; Others
	4,5-Dicaffeoylquinic acid (Isochlorogenic acid C) 是一种天然产物，有抗病毒、抗肝毒性活性。
TMO2713	4(3H)-Quinazolinone Quinazolin-4-ol,4-Hydroxyquinazoline,4-羟基喹唑啉,4-Quinazolinol,4-Quinazolone,4-Quinazolinone	Antibacterial; Platelet aggregation	Microbiology/Virology; Others
	4(3H)-Quinazolinone (4-Hydroxyquinazoline) 是化学合成中的砌块，是一种生物活性氮杂环化合物。它具有多种生物学特性，如抗菌，抗真菌，抗惊厥，抗炎，抗 HIV，抗癌和缓解疼痛活性。
TN1622	Ermanin 堪非醇3,4'-二-O-甲醚	NOS; Influenza Virus; COX; HIV Protease; Antibacterial; Antibiotic	Immunology/Inflammation; Microbiology/Virology; Neuroscience; Proteases/Proteasome
	Ermanin 是一种从 Tanacetum microphyllum 中分离出来的类黄酮。Ermanin抑制血小板聚集，具有抗结核和抗病毒/细菌特性。Ermanin 可抑制 iNOS 和 COX-2 的表达，从而具有抗炎活性。Ermanin 可能具有抗 HIV-1 活性。Ermanin 在较低浓度下可有效地抑制 Dione juno 幼虫。
T4537	Cholic acid sodium 胆酸钠,[胆酸钠],SodiumCholate	HIV Protease; Endogenous Metabolite	Metabolism; Microbiology/Virology; Proteases/Proteasome
	Cholic acid sodium (SodiumCholate) 是肝脏中产生的主要胆汁酸，通常与牛磺酸或甘氨酸结合，有助于脂肪吸收和胆固醇排泄。
T4S1718	Punicalin	HBV; HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Punicalin 是从Punica granatumL. 或Terminalia catappaL. 的叶子中分离的，一种可水解的单宁，具有抗炎活性。它是一种抗乙型肝炎病毒药物。
T4S0295	Apigenin 7-glucoside 波斯菊,Cosmetin,Cosmosiin,Cosmosioside,Apigenin-7-O-β-D-glucopyranoside,芹甙元-7-葡萄糖苷,Thalictiin,Apigetrin	Reactive Oxygen Species; HIV Protease	Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB; Proteases/Proteasome
	Apigenin 7-glucoside (Cosmosiin) 是一种 ROS 清除剂，具有抗增殖、抗氧化作用。
T4S1383	Escin IA Aescin IA,Escin IA;Aescin IA,Escin IA	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Escin IA (Escin IA;Aescin IA);Aescin IA 是从马蹄中七叶树分离出的一种三萜皂苷，抑制HIV-1蛋白酶，IC50值为 35 μM。它具有抗 TNBC 转移活性，其作用机制涉及通过下调 LOXL2 表达抑制上皮-间质转化过程。
T5S1103	Isoliensinine 异莲心碱,Isoliensinin	Apoptosis; Antioxidant	Apoptosis; oxidation-reduction
	Isoliensinine (Isoliensinin) 是从水芙蓉种子胚中提取的一种双苄基异喹啉生物碱，能诱导三阴性乳腺癌细胞凋亡，具有抗氧化、抗炎、抗癌活性。
TN1727	Helichrysetin 4,2',4'-三羟基-6'-甲氧基查耳酮,蜡菊亭	Apoptosis; HIV Protease	Apoptosis; Microbiology/Virology; Proteases/Proteasome
	Helichrysetin 是从豆蔻果实中分离出的一种天然产物，是一种 DNA 结合抑制剂，可抑制原位导管癌DCIS 的形成。它抑制细胞生长，可诱导 A549 细胞凋亡。
TJS1779	Protosappanin A 原苏木素A,PTA	NADPH-oxidase; IL Receptor; IκB/IKK; TNF; NF-κB; TLR; ROS; COX; HIV Protease; JAK; NO Synthase; STAT	Angiogenesis; Apoptosis; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; Microbiology/Virology; Neuroscience; NF-κB; Proteases/Proteasome; Stem Cells
	Protosappanin A (PTA) 是从苏木中分离得到的免疫抑制成分和主要联苯化合物，通过下调 JAK2和 STAT3的磷酸化，抑制 JAK2/STAT3依赖的炎症通路。
T3388	Calycosin-7-O-β-D-glucoside 毛蕊异黄酮苷,calycosin-7-O-beta-D-glucopyranoside,Calycosin-7-O-beta-D-glucoside	MMP; Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB; Proteases/Proteasome
	Calycosin-7-O-β-D-glucoside (calycosin-7-O-beta-D-glucopyranoside) 是一种异黄酮，从黄芪中分离得到。它具有多种生物活性，包括心脏保护、神经保护、抗炎和抗氧化作用。
T5429	Theaflavin 3,3'-digallate 茶黄素-3,3'-双没食子酸,8-Gingerol,TFDG	Virus Protease; Antioxidant; HIV Protease; HSV	Microbiology/Virology; oxidation-reduction; Proteases/Proteasome
	Theaflavin 3,3'-digallate (8-Gingerol) 是一种寨卡病毒蛋白酶抑制剂，IC50为 2.3 μM。它直接与 ZIKVpro 结合并抑制 ZIKV 复制，可抑制 gp41 和 NS2B-3 蛋白酶的活性，并具有抗 HSV 和 HIV-1病毒活性。它是红茶中的主要多酚，有抗肿瘤作用。
T4S0797	Berberine 小檗碱,Berberin,Umbellatine,黄连素	Reactive Oxygen Species; Topoisomerase; Endogenous Metabolite; Antibacterial; Antibiotic; Autophagy	Autophagy; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB
	Berberine (Umbellatine) 是从中草药黄连中分离出来的一种生物碱抗生素。它诱导活性氧生成并抑制 DNA 拓扑异构酶，具有抗肿瘤特性。
TN3567	Calanolide E 胡桐，海棠木	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Calanolide E2 has anti-HIV activity.
TN5191	Tsugafolin	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Tsugafolin has weak anti-HIV activity.
TN4555	Methyl salvionolate A	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Methyl salvionolate A has anti-HIV-1 activity.
TN4820	Pre-schisanartanin B	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Pre-schisanartanin B has cytotoxicity, it also has anti-HIV-1 activity.
TN3705	Coronalolide methyl ester	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Coronalolide methyl ester displays significant anti-HIV activities in the HIV-1RT assay. It and coronalolide show broad cytotoxic activity against a panel of human cancer cell lines.
T40252	Peritassine A
	Peritassine A, an alkaloid derived from Tripterygium wilfordii Hook. f., exhibits anti-HIV properties.
TN1708	Gomisin M2 五味子脂素 M2	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Gomisin M2 is an anti-HIV agent.
TN5177	Trigothysoid N	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Trigothysoid N may have anti-HIV activity.
T14196	Alternariol	Others	Others
	Alternariol (AOH), a mycotoxin synthesized by Alternaria species, displays numerous therapeutic and biological effects, including phytotoxic, cytotoxic, anti-HIV, anti-cancer, and anti-microbial properties. It functions by inhibiting the catalytic activity of topoisomerase I and II enzymes.
TN6541	Cleomiscosin B
	Cleomiscosins A, B and C exhibit liver-protective properties. Cleomiscosin B shows the potent anti-HIV-1 activity in vitro and also has protective effects on MT4 cells infected by HIV-1(IIIB).
TN4835	Przewalskin	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Przewalskin A and Przewalskin B showed modest anti-HIV-1 activity with EC50 = 41 and 30 microg/mL, respectively.
TN5012	Shizukaol C	HIV Protease; Antifection	Microbiology/Virology; Proteases/Proteasome
	1. Shizukaol C shows anti-HIV-1 replication activities in both wild-type HIV-1 and two NNRTIs-resistant strains. <br/> 2. Shizukaol C has significant cytotoxicities against C8166 cells. <br/>
TN4109	Ganolucidic acid A	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Ganolucidic acid A exhibits cytotoxicity, has inhibitory activities against human HeLa cervical cancer cell lines. It shows significant anti-human immunodeficiency virus (anti-HIV)-1 protease activity with IC50 values of 20-90 microM.
TN4539	Methyl chanofruticosinate	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Methyl chanofruticosinate has weak anti-HIV-1 activity.
TN5401	R(+)-Gomisin M1 R(+)-戈米辛M1
	(+/-)-Gomisin M1 exhibits potent anti-HIV activity, with EC50 and therapeutic index (TI) values of <0.65 microM and >68, respectively.
TN2186	Schisantherin D	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Schisantherin D shows good anti-HIV activity with the EC50 value of 0.5 micrograms/mL, and the therapeutic index (TI) value of 110.
TN5133	3',5,5',7-Tetrahydroxy-4',6-dimethoxyflavone	HIV Protease; Topoisomerase	DNA Damage/DNA Repair; Microbiology/Virology; Proteases/Proteasome
	5,7,3',5'-tetrahydroxy-6,4'-dimethoxyflavone exhibits anti-HIV-1 activity in the anti-syncytium assay using (∆Tat/rev)MC99 virus and 1A2 cell line system, it shows considerably activity against HIV-1 reverse transcriptase. It exhibits cytotoxic activity against P-388 cell lines, it can inhibit DNA topoisomerase IIα activity, which may be responsible for the observed cytotoxicity.
TN2284	Triptonine B	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Triptonine B demonstrates potent anti-HIV activity with an EC(50) value of <0.10 microg/mL and an in vitro therapeutic index value of >1000.
T79956	Interiorin
	Interiorin是从Kadsura heteroclita中分离出的化合物，显示出中等程度的抗HIV活性，其EC50为1.6 lg/mL。
TN3777	Daurichromenic acid	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Daurichromenic acid is a terpenophenol with a potent anti-HIV activity.
TN1943	Momordicoside G	Others	Others
	Momordicosides K and L, the main bitter taste triterpene glycosides in Bitter melon; and bitter melon has been reported to have hypoglycemic, anti atherogenic and anti HIV activities.
T75660	(-)-Rabdosiin
	(-)-Rabdosiin 是一种新型的酚类标记物，从Symphytum officinaleL. 中发现。 (-)-Rabdosiin 具有抗氧化、神经保护和抗HIV 的活性。
T10011	1,3,5-Tricaffeoylquinic acid	Others	Others
	1,3,5-Tricaffeoylquinic acid is a tricaffeoylquinic acid derivative isolated from Helichrysum populifolium with anti-HIV effect.
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天然产物

Cat.No: TN2283

Target: HIV Protease

Cat.No: T12651

Synonym: (+)-Rabdosiin

Target: Others

Cat.No: T2S0731

Synonym: 三叶苷,三叶甙,P-Phlorizin

Target: Amylase

Dimethyl fumarate

Cat.No: T0492

Synonym: 富马酸二甲酯,DMF

Target: Reactive Oxygen Species, HIV Protease, Nrf2, Endogenous Metabolite, Autophagy

Cat.No: T0070

Synonym: Oxpentifylline,PTX,己酮可可碱,BL-191

Target: HIV Protease, PDE, Adenosine Receptor, Autophagy

Cat.No: T4S1387

Synonym: 七叶皂苷C,异七叶皂苷 IA

Target: HIV Protease

Cat.No: T2775

Synonym: 黄芩苷,黄岑苷,Baicalein 7-O-β-D-glucuronide

Target: NF-κB, HIV Protease, GABA Receptor, Autophagy

Cat.No: T3730

Synonym: NSC 363001,Gallicin,Gallic acid methyl ester,Gallincin,没食子酸甲酯

Target: Reactive Oxygen Species, HIV Protease, Reverse Transcriptase, Antibacterial

Cat.No: TQ0217

Synonym: 戈米辛G,戈米辛 G

Target: P450, HIV Protease

Cat.No: T5783

Synonym: 野蔷薇苷,罗莎白素

Target: Antioxidant, HIV Protease

lithospermic acid

Cat.No: T3683

Target: HIV Protease

Cat.No: T8689

Synonym: CQ,氯喹

Target: SARS-CoV, TLR, HIV Protease, Antibiotic, Parasite, Autophagy

Zingibroside R1

Cat.No: T4962

Synonym: Ginsenoside Z-R1,姜状三七皂苷R1,姜状三七苷R1

Target: HIV Protease

Cat.No: T8859

Target: Others

4,5-Dicaffeoylquinic acid

Cat.No: T2S1158

Synonym: 3,4-Dicaffeoylquinic acid,异绿原酸C(4,5),Isochlorogenic acid C

Target: Others, HBV, Endogenous Metabolite

4(3H)-Quinazolinone

Cat.No: TMO2713

Synonym: Quinazolin-4-ol,4-Hydroxyquinazoline,4-羟基喹唑啉,4-Quinazolinol,4-Quinazolone,4-Quinazolinone

Target: Antibacterial, Platelet aggregation

Cat.No: TN1622

Synonym: 堪非醇3,4'-二-O-甲醚

Target: NOS, Influenza Virus, COX, HIV Protease, Antibacterial, Antibiotic

Cholic acid sodium

Cat.No: T4537

Synonym: 胆酸钠,[胆酸钠],SodiumCholate

Target: HIV Protease, Endogenous Metabolite

Cat.No: T4S1718

Target: HBV, HIV Protease

Apigenin 7-glucoside

Cat.No: T4S0295

Synonym: 波斯菊,Cosmetin,Cosmosiin,Cosmosioside,Apigenin-7-O-β-D-glucopyranoside,芹甙元-7-葡萄糖苷,Thalictiin,Apigetrin

Target: Reactive Oxygen Species, HIV Protease

Cat.No: T4S1383

Synonym: Aescin IA,Escin IA;Aescin IA,Escin IA

Target: HIV Protease

Cat.No: T5S1103

Synonym: 异莲心碱,Isoliensinin

Target: Apoptosis, Antioxidant

Cat.No: TN1727

Synonym: 4,2',4'-三羟基-6'-甲氧基查耳酮,蜡菊亭

Target: Apoptosis, HIV Protease

Protosappanin A

Cat.No: TJS1779

Synonym: 原苏木素A,PTA

Target: NADPH-oxidase, IL Receptor, IκB/IKK, TNF, NF-κB, TLR, ROS, COX, HIV Protease, JAK, NO Synthase, STAT

Calycosin-7-O-β-D-glucoside

Cat.No: T3388

Synonym: 毛蕊异黄酮苷,calycosin-7-O-beta-D-glucopyranoside,Calycosin-7-O-beta-D-glucoside

Target: MMP, Reactive Oxygen Species

Theaflavin 3,3'-digallate

Cat.No: T5429

Synonym: 茶黄素-3,3'-双没食子酸,8-Gingerol,TFDG

Target: Virus Protease, Antioxidant, HIV Protease, HSV

Cat.No: T4S0797

Synonym: 小檗碱,Berberin,Umbellatine,黄连素

Target: Reactive Oxygen Species, Topoisomerase, Endogenous Metabolite, Antibacterial, Antibiotic, Autophagy

Cat.No: TN3567

Synonym: 胡桐，海棠木

Target: HIV Protease

Cat.No: TN5191

Target: HIV Protease

Methyl salvionolate A

Cat.No: TN4555

Target: HIV Protease

Pre-schisanartanin B

Cat.No: TN4820

Target: HIV Protease

Coronalolide methyl ester

Cat.No: TN3705

Target: HIV Protease

Cat.No: T40252

Cat.No: TN1708

Synonym: 五味子脂素 M2

Target: HIV Protease

Cat.No: TN5177

Target: HIV Protease

Cat.No: T14196

Target: Others

Cat.No: TN6541

Cat.No: TN4835

Target: HIV Protease

Cat.No: TN5012

Target: HIV Protease, Antifection

Ganolucidic acid A

Cat.No: TN4109

Target: HIV Protease

Methyl chanofruticosinate

Cat.No: TN4539

Target: HIV Protease

R(+)-Gomisin M1

Cat.No: TN5401

Synonym: R(+)-戈米辛M1

Schisantherin D

Cat.No: TN2186

Target: HIV Protease

3',5,5',7-Tetrahydroxy-4',6-dimethoxyflavone

Cat.No: TN5133

Target: HIV Protease, Topoisomerase

Cat.No: TN2284

Target: HIV Protease

Cat.No: T79956

Daurichromenic acid

Cat.No: TN3777

Target: HIV Protease

Momordicoside G

Cat.No: TN1943

Target: Others

Cat.No: T75660

1,3,5-Tricaffeoylquinic acid

Cat.No: T10011

Target: Others

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