Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tenofovir alafenamide fumarate (GS-7340 fumarate) 是一种可口服的 Tenofovir 前体化合物。Tenofovir alafenamide fumarate 具有抗 HIV 活性,可用于预防 HIV 感染。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 218 | 现货 | ||
5 mg | ¥ 497 | 现货 | ||
10 mg | ¥ 747 | 现货 | ||
25 mg | ¥ 1,070 | 现货 | ||
50 mg | ¥ 1,590 | 现货 | ||
100 mg | ¥ 2,370 | 现货 | ||
500 mg | ¥ 5,630 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 648 | 现货 |
产品描述 | Tenofovir alafenamide fumarate (GS-7340 fumarate) is an orally available Tenofovir precursor compound Tenofovir alafenamide fumarate has anti-HIV activity and can be used to prevent HIV infection. |
体外活性 | Tenofovir alafenamide fumarate antiviral activity was similar in all cell types, ranging from 5 to 7 nM, whereas CC50 varied from 4.7 to 42 μM for MT-4 and MT-2 cells. The antiviral activity of TAF was evaluated against a panel of HIV-1 and HIV-2 isolates, including HIV-1 M group subtypes A to G, as well as group N and O isolates. Overall, TAF EC50 ranged from 0.1 to 12 nM, with an average EC50 of 3.5 nM, compared to an average EC50 of 11.8 nM for AZT, used as an internal control, for 29 major HIV-1 isolates tested in PBMC. For HIV-2 isolates, the average EC50 is 1.8 nM for TAF and 6.4 nM for AZT.[2] |
体内活性 | Tenofovir alafenamide fumarate(GS-7340 fumarate)作为Tenofovir的酰胺前药,相较于Tenofovir disoproxil fumarate(TDF)[1],具有良好的口服生物利用度并增强了血浆稳定性。 |
别名 | GS-7340 fumarate |
分子量 | 592.54 |
分子式 | C25H33N6O9P |
CAS No. | 379270-38-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 25 mg/mL (42.19 mM), Sonication is recommended.
DMSO: 200 mg/mL (337.53 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
H2O / DMSO | 1 mM | 1.6876 mL | 8.4382 mL | 16.8765 mL | 42.1912 mL |
5 mM | 0.3375 mL | 1.6876 mL | 3.3753 mL | 8.4382 mL | |
10 mM | 0.1688 mL | 0.8438 mL | 1.6876 mL | 4.2191 mL | |
20 mM | 0.0844 mL | 0.4219 mL | 0.8438 mL | 2.1096 mL | |
DMSO | 50 mM | 0.0338 mL | 0.1688 mL | 0.3375 mL | 0.8438 mL |
100 mM | 0.0169 mL | 0.0844 mL | 0.1688 mL | 0.4219 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Tenofovir alafenamide fumarate 379270-38-9 Microbiology/Virology Proteases/Proteasome HIV Protease Tenofovir alafenamide Fumarate GS-7340 Fumarate GS7340 Fumarate GS 7340 Fumarate GS-7340 fumarate Inhibitor inhibitor inhibit