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205

抑制剂 & 化合物

79

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T12979	BI-3406	p38 MAPK; MAPK; Ras	GPCR/G Protein; MAPK
	BI-3406 是一种可口服、高效且选择性的 KRAS-SOS1 抑制剂，具有抗癌活性。它有效减少 GTP 加载的 KRAS 的形成，抑制 MAPK 信号通路。它还抑制 KRAS 与 SOS1之间相互作用，IC50为 6 nM。
T15102	Dexamethasone palmitate 地塞米松棕榈酸酯,DXP	Glucocorticoid Receptor	Endocrinology/Hormones
	Dexamethasone palmitate (DXP) (DXP) 是 Dexamethasone 的前药。Dexamethasone 是糖皮质激素受体激动剂。与Dexamethasone 相比， DXP 对糖皮质激素受体的亲和力低 47 倍。DXP 显示出抗炎活性。
T32114	Hydrocortisone aceponate Suniderma,Efficort,Hydrocortisone 17-propionate 21-acetate	Glucocorticoid Receptor	Endocrinology/Hormones
	Hydrocortisone aceponate (Hydrocortisone 17-propionate 21-acetate) 是一种有效的外用糖皮质激素，以乳膏的形式用于治疗各种皮肤病。
T34914	Trabodenoson INNO-8875,INO-8875,PJ875,PJ-875,INNO 8875,INNO8875,PJ 875	Adenosine Receptor	GPCR/G Protein; Neuroscience
	Trabodenoson (INO-8875) 是一种具有选择性和有效性的的腺苷 A1 受体激动剂，是一种腺苷类似物，可用于研究原发性开角型青光眼。
T0947L	Dexamethasone Phosphate disodium 地塞米松磷酸二钠,EGP-437,EGP437. Dex-Phos,EGP 437	Glucocorticoid Receptor	Endocrinology/Hormones
	Dexamethasone Phosphate disodium (EGP437. Dex-Phos) 是糖皮质激素受体激动剂。
T50086	Clomesone	Others	Others
	Clomesone 是一种合成的非甾体药物，可用作分子结构单元。它是一种常用于治疗女性不孕的药物，通过阻断大脑中雌激素的作用发挥作用，已被证明对患有多囊卵巢综合征和其他不孕问题的女性有效诱导排卵。
T38013	Sonlicromanol hydrochloride
	Sonlicromanol hydrochloride (KH176), a derivative of Trolox, is a ROS-redox modulator that effectively crosses the blood-brain barrier. It is specifically employed in the investigation of mitochondrial disorders[1].
T35903	N-acetyl Dapsone	Antibacterial; Parasite	Microbiology/Virology
	N-acetyl Dapsone 是一种抗炎和抗菌化合物，广泛用于治疗麻风病、疟疾、痤疮和各种免疫疾病。
T4279	Esonarimod KE-298	IL Receptor	Immunology/Inflammation
	Esonarimod (KE-298) 是一种具有抗风湿作用的化合物。
T1365	Thioisonicotinamide Pyridine-4-carbothioamide,Isothionicotinamide,硫代异烟酰胺,4-Pyridylthiocarboxamide	Antibiotic	Microbiology/Virology
	Thioisonicotinamide (Isothionicotinamide) 是一种可用于药物合成的合成中间体。
T1926	Sonidegib Erismodegib,NVP-LDE225,LDE225	Hedgehog/Smoothened; Smo	GPCR/G Protein; Stem Cells
	Sonidegib (Erismodegib) 是一种Smo 的选择性拮抗剂，能够抑制鼠 Smo (IC50:1.3 nM)和人 Smo (IC50:2.5 nM)。
T5005	Eperisone hydrochloride	Others	Others
	Eperisone Hydrochloride 是一种抗痉挛试剂，用于肌肉僵硬和疼痛为特征的疾病的相关研究。它是一种中枢作用的肌肉松弛剂，抑制疼痛反射通路，具有血管扩张作用。它通过放松骨骼肌和血管平滑肌来起作用，例如减少肌张力，改善循环和抑制疼痛反射。
T2671	Regadenoson CVT-3146,瑞加德松,Lexiscan	Adenosine Receptor	GPCR/G Protein; Neuroscience
	Regadenoson (CVT-3146) 是一种腺苷衍生物和选择性 A2A 腺苷受体激动剂，具有冠状动脉舒张活性，对大鼠和猪腺苷 A2A 受体的Ki 分别为 290 和 1120 nM。它是血管扩张剂，可增加啮齿动物血脑屏障的通透性。
T23380	Sonepiprazole	Dopamine Receptor	GPCR/G Protein; Neuroscience
	Sonepiprazole 是D4多巴胺受体选择性拮抗剂，与rD4多巴胺受体，hD4.2多巴胺受体，rD2多巴胺受体和组胺H1受体结合的Ki 分别为 3.6、10.1、5147 和 7430 nM。
T1076	Dexamethasone MK 125,Prednisolone F,NSC 34521,Hexadecadrol,地塞米松	Glucocorticoid Receptor; Mitophagy; IL Receptor; SARS-CoV; Antibacterial; Antibiotic; Autophagy; Complement System	Autophagy; Endocrinology/Hormones; Immunology/Inflammation; Microbiology/Virology
	Dexamethasone (Hexadecadrol) 是一种糖皮质激素受体激动剂和一种 IL 受体调节剂。Dexamethasone 具有抗炎和免疫抑制活性，可诱导自噬。Dexamethasone 抑制 LPS 诱导的巨噬细胞炎症反应。
T0972	Isoniazid INH,异烟肼,Isonicotinic acid hydrazide,Isonicotinic hydrazide	Mitophagy; Dehydrogenase; CAT; Antibacterial; Autophagy	Autophagy; Metabolism; Microbiology/Virology; oxidation-reduction
	Isoniazid (Isonicotinic hydrazide) 是一种必须被细菌过氧化氢酶 KatG 激活的前药，具有抗菌活性。它对快速分裂的分枝杆菌具有杀菌作用。
T21404	Fluticasone furoate Veramyst,Allermist,Avamys,糠酸氟替卡松,Fluticasone furoate	Glucocorticoid Receptor	Endocrinology/Hormones
	Fluticasone furoate (Avamys) 是一种合成的三氟化皮质类固醇，衍生自氟替卡松，Kd 为 0.3 nM。Fluticasone furoate 具有有效的抗炎、抗哮喘活性和低全身暴露。Fluticasone furoate 可用作过敏性鼻炎治疗研究的鼻喷雾剂。
T20763	Betamethasone disodium phosphate Vista-Methasone,NSC90616,Betamethasone 21-phosphate disodium salt,NSC-90616	Others	Others
	Betamethasone disodium phosphate (Betamethasone 21-phosphate disodium salt) 是一种具有抗炎活性的皮质类固醇，通过减少促炎细胞因子的分泌促进 M1 至 M2 巨噬细胞极化，可用于研究瘢痕疙瘩和类风湿性关节炎。
T4275	Fluanisone Sedalande,氟苯丙酮哌嗪,Haloanison	Others	Others
	Fluanisone (Haloanison) 是一种苯丁酮衍生物，具有镇静作用。它是一种典型的抗精神病药，用于治疗精神分裂症。
T21361	Alclometasone dipropionate Vaderm,Sch 22219,Aclovate,Delonal	Others	Others
	Alclometasone dipropionate （Sch 22219）是一种人工合成的糖皮质激素，属于类固醇化合物，具有抗增生、抗炎、抗过敏、止痒和收缩血管的作用，可用于研究皮肤炎症。
T14324	Artemisone BAY 44-9585,Artemifone,青蒿酮	Others; Parasite	Microbiology/Virology; Others
	Artemisone (BAY 44-9585) 是一种半合成的有效抗疟疾剂，还是一种人CMV 的有效抑制剂，可抑制多种P. falciparum，平均IC50值为 0.83 nM。
T20802	Flumethasone pivalate Locacorten,NSC-107680,特戊酸氟米松,Lorinden,NSC 107680,NSC107680,Locorten	Others	Others
	Flumethasone pivalate (Locorten) 具有止痒、抗炎和血管收缩的特性，可用于肾上腺皮质抑制、皮肤萎缩、血浆转皮质素结合和毛细血管扩张的研究。
T10991	Dehydronitrosonisoldipine	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Dehydronitrosonisoldipine 是一种不育α和含TIR 图案1的抑制剂，可用于有关神经退行性疾病的研究。Dehydronitrosonisoldipine 抑制轴突退化和长春碱激活的神经元中cADPR 的产生。
TQ0125	Capadenoson BAY 68-4986,卡帕诺生	Adenosine Receptor	GPCR/G Protein; Neuroscience
	Capadenoson (BAY 68-4986) 是 A1 腺苷受体的选择性激动剂。
T1666L	Fludrocortisone 9α-fluorocortisol,9α-Fludrocortisone,Florinef,9α-fluorohydrocortisone,氟氢可的松,Fludrocortisone acetate,Astonin,9α-Fluorcortisol	Others	Others
	Fludrocortisone (Florinef) 是一种合成皮质类固醇，具有中等的糖皮质激素效力和更大的盐皮质激素效力。Fludrocortisone (Florinef) 可用于治疗低血压的研究。
T1666	Fludrocortisone acetate 9α-Fluorcortisol acetate,9α-Fludrocortisone acetate,醋酸氟氢可的松,9α-fluorocortisol acetate	Glucocorticoid Receptor; Autophagy	Autophagy; Endocrinology/Hormones
	Fludrocortisone acetate (9α-Fludrocortisone acetate) 是一种合成的盐皮质激素，可减少尿液中钠丢失量，也用于增加血压，有用于阿狄森氏病的研究潜力。
T2526	Ciclesonide Zetonna,环索奈德,RPR251526,Omnaris,Alvesco	Glucocorticoid Receptor	Endocrinology/Hormones
	Ciclesonide (Alvesco) 是一种糖皮质激素，具有强效抗炎活性，可用于研究哮喘。
T0270	Hydrocortisone 17-butyrate 丁酸氢化可的松,Cortisol 17-butyrate,Hydrocortisone butyrate	Glucocorticoid Receptor; Annexin A; Adrenergic Receptor	Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	Hydrocortisone 17-butyrate (Cortisol 17-butyrate) 是一种肾上腺皮质激素类药物。
T0552	Isonicotinamide	Others	Others
	Isonicotinamide 用作医药中间体，用于合成头孢氯铵等。
T21899	Misonidazole SR-1354,SR1354,Ro 7-0582	GPX	oxidation-reduction
	Misonidazole 是一种缺氧肿瘤细胞放射增敏剂，具有抗菌活性。
T28748	Selodenoson RG14202,DTI0009,DTI-0009,RG-14202,DT-009,DT009	Adenosine Receptor	GPCR/G Protein; Neuroscience
	Selodenoson (RG-14202) 是一种选择性腺苷 A1 受体激动剂，可用于减慢心房颤动患者的心率，治疗心律失常。
T68087	Inaperisone	Others	Others
	Inaperisone 是一种新型的中枢作用的肌肉松弛剂，对排尿反射有抑制作用。Inaperisone 可能通过间接作用于脑干的GABAB 受体来抑制排尿反射。
T8396	Prednisone acetate Prednisone 21-acetate,醋酸泼尼松	Glucocorticoid Receptor	Endocrinology/Hormones
	Prednisone acetate (Prednisone 21-acetate) 是泼尼松的醋酸盐形式，它是一种糖皮质激素受体激动剂，具有抗炎和免疫调节作用。
T0511	Tolperisone hydrochloride 盐酸托哌酮,Muscalm,Midocalm,托哌酮盐酸盐,Tolperisone HCl	Sodium Channel	Membrane transporter/Ion channel
	Tolperisone hydrochloride (Muscalm) 是中枢作用肌肉松弛剂，可用于研究神经疾病引起的病理性横纹肌硬化(锥体束损伤、脊髓病、多发性硬化症、脑脊髓炎)、痉挛性麻痹及其他肌肉张力障碍相关的脑病。
T0094	Budesonide Entocort,Pulmicort,布地奈德,Rhinocort	Glucocorticoid Receptor	Endocrinology/Hormones
	Budesonide (Pulmicort) 是吸入型糖皮质类固醇，是一种口服具有活性的糖皮质激素受体激动剂。它能够减小肺部肿瘤的体积，逆转 DNA 低度甲基化，调节基因的 mRNA 表达。它是能够用于哮喘的抗炎药。
T8777	Beclometasone 倍氯米松,BecloMethasone	Glucocorticoid Receptor	Endocrinology/Hormones
	Beclometasone 是糖皮质激素受体激动剂。
T14981	Clobetasone butyrate	Glucocorticoid Receptor	Endocrinology/Hormones
	Clobetasone butyrate 是糖皮质类固醇，特别是在皮肤上，具有局部抗炎活性。它可用于改善皮质类固醇反应性症状，如特应性皮炎、牛皮癣。
T4602	Hydrocortisone hemisuccinate Hydrocortisone 21-he,氢化可的松琥珀酸酯,hydrocortisone 21-hemisuccinate*free acid,Hydrocortisone 21-hemisuccinate	Glucocorticoid Receptor; Others; Interleukin	Endocrinology/Hormones; Immunology/Inflammation; Others
	Hydrocortisone hemisuccinate (hydrocortisone 21-hemisuccinate*free acid) 是糖皮质激素，是口服有活性的甾体抗炎剂。它能够降低IL-6(IC50:6.7 μM)、IL-3(IC50:21.4 μM)的生物活性，可用于研究溃疡性结肠炎。
T0276	Hydrocortisone Valerate Westcort,氢化可的松戊酸酯	Glucocorticoid Receptor	Endocrinology/Hormones
	Hydrocortisone Valerate (Westcort) 具有抗炎、止痒和血管收缩的特性。
T1124	Flumethasone 氟米松,Flumetasone,RS-2177,NSC-54702	Glucocorticoid Receptor	Endocrinology/Hormones
	Flumethasone (RS-2177) 是皮质类固醇，可局部用药。它可与 Clioquinol 联合使用，研究外耳炎和耳真菌病。它作用于动物模型时，抗炎活性比 Cortisone 高 420 倍。
T5314	pyridoxal isonicotinoyl hydrazone 吡哆醛异烟酰肼,PIH	Others	Others
	pyridoxal isonicotinoyl hydrazone (PIH) 是亲脂的三价铁螯合剂，具有高铁螯合特性。
T28778	Silperisone HCl RGH5002,SILA336,RGH-5002,Silperisone hydrochloride,SILA-336
	Silperisone HCl (RGH-5002) 阻断细胞中的钠和钙通道，使肌肉细胞的兴奋度和收缩度降低，降低外周张力，充当肌肉松弛剂和外周血管扩张剂。 Silperisone HCl 可用于治疗脊髓损伤引起的复发性疼痛性肌阵挛、脑血管病引起的异常高肌张力、肌张力症状、锥体紧张综合征、多发性硬化症肌痉挛和脊髓炎。Silperisone 是钠通道蛋白2型α通道阻滞剂。Silperisone 是一种类似于tolperisone 的有机硅化合物，具有中枢作用的肌肉松弛剂特性。
T6884	Namodenoson 2-Cl-IB-MECA,CF-102	Adenosine Receptor	GPCR/G Protein; Neuroscience
	Namodenoson (2-Cl-IB-MECA) 是一个选择性的 A3 腺苷受体 (A3AR) 激动剂，Ki 为 0.33 nM，选择性分别是 A1 和 A2 的 2500 和 1400 倍。
T76828	Sonepcizumab LT 1009	LPL Receptor	GPCR/G Protein
	Sonepcizumab (LT 1009) 是一种完全人源化的抗 S1P 单克隆抗体。Sonepcizumab 具有抗癌活性，可用于研究转移性肾细胞癌 (mRCC) ，可预防青光眼滤过手术后的眼部瘢痕形成。
T22348	Isonipecotic acid 4-Piperidinecarboxylic acid,Hexahydroisonicotinic acid,4-哌啶甲酸,4-Carboxypiperidine	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	Isonipecotic acid (4-Piperidinecarboxylic acid) 是一种杂环化合物。它主要表征为 GABAA 受体部分激动剂。
T19277	Dexamethasone 9,11-epoxide	Others	Others
	Dexamethasone 9,11-epoxide 是一种萃取得到的化合物，是制备地塞米松的中间体。
T34685	Sonedenoson MRE-0094,MRE0094,MRE 0094
	Sonedenoson( MRE0094) is an adenosine A2A receptor agonist that promotes rapid wound healing.
T6465	Dexamethasone Sodium Phosphate Dexadreson,地塞米松磷酸钠,Dexagro,Dalalone	IL Receptor; COX	Immunology/Inflammation; Neuroscience
	Dexamethasone Sodium Phosphate (Dexadreson) 是一种白细胞介素受体调节剂，具有抗炎和免疫抑制作用。它属于类固醇合成药物的强效糖皮质激素类。
T7188	Piclidenoson CF-101,IB-MECA	Apoptosis; Adenosine Receptor	Apoptosis; GPCR/G Protein; Neuroscience
	Piclidenoson (CF-101) 是一种具有口服活性的，选择性的腺苷 A3 受体激动剂。它在不同类型的癌细胞如黑色素瘤、白血病中表现出抗增殖和诱导凋亡的作用，可研究自身免疫性炎症疾病和 COVID-19。
T15727	Sonidegib diphosphate NVP-LDE 225 diphosphate,Erismodegib diphosphate,LDE225 diphosphate	Smo	Stem Cells
	Sonidegib diphosphate (LDE225 diphosphate) 是 Smo 的选择性拮抗剂，能够抑制鼠 Smo (IC50:1.3 nM)和人 Smo (IC50:2.5 nM)。

化合物

Cat.No: T12979

Target: p38 MAPK, MAPK, Ras

Dexamethasone palmitate

Cat.No: T15102

Synonym: 地塞米松棕榈酸酯,DXP

Target: Glucocorticoid Receptor

Hydrocortisone aceponate

Cat.No: T32114

Synonym: Suniderma,Efficort,Hydrocortisone 17-propionate 21-acetate

Target: Glucocorticoid Receptor

Cat.No: T34914

Synonym: INNO-8875,INO-8875,PJ875,PJ-875,INNO 8875,INNO8875,PJ 875

Target: Adenosine Receptor

Dexamethasone Phosphate disodium

Cat.No: T0947L

Synonym: 地塞米松磷酸二钠,EGP-437,EGP437. Dex-Phos,EGP 437

Target: Glucocorticoid Receptor

Cat.No: T50086

Target: Others

Sonlicromanol hydrochloride

Cat.No: T38013

N-acetyl Dapsone

Cat.No: T35903

Target: Antibacterial, Parasite

Cat.No: T4279

Synonym: KE-298

Target: IL Receptor

Thioisonicotinamide

Cat.No: T1365

Synonym: Pyridine-4-carbothioamide,Isothionicotinamide,硫代异烟酰胺,4-Pyridylthiocarboxamide

Target: Antibiotic

Cat.No: T1926

Synonym: Erismodegib,NVP-LDE225,LDE225

Target: Hedgehog/Smoothened, Smo

Eperisone hydrochloride

Cat.No: T5005

Target: Others

Cat.No: T2671

Synonym: CVT-3146,瑞加德松,Lexiscan

Target: Adenosine Receptor

Sonepiprazole

Cat.No: T23380

Target: Dopamine Receptor

Cat.No: T1076

Synonym: MK 125,Prednisolone F,NSC 34521,Hexadecadrol,地塞米松

Target: Glucocorticoid Receptor, Mitophagy, IL Receptor, SARS-CoV, Antibacterial, Antibiotic, Autophagy, Complement System

Cat.No: T0972

Synonym: INH,异烟肼,Isonicotinic acid hydrazide,Isonicotinic hydrazide

Target: Mitophagy, Dehydrogenase, CAT, Antibacterial, Autophagy

Fluticasone furoate

Cat.No: T21404

Synonym: Veramyst,Allermist,Avamys,糠酸氟替卡松,Fluticasone furoate

Target: Glucocorticoid Receptor

Betamethasone disodium phosphate

Cat.No: T20763

Synonym: Vista-Methasone,NSC90616,Betamethasone 21-phosphate disodium salt,NSC-90616

Target: Others

Cat.No: T4275

Synonym: Sedalande,氟苯丙酮哌嗪,Haloanison

Target: Others

Alclometasone dipropionate

Cat.No: T21361

Synonym: Vaderm,Sch 22219,Aclovate,Delonal

Target: Others

Cat.No: T14324

Synonym: BAY 44-9585,Artemifone,青蒿酮

Target: Others, Parasite

Flumethasone pivalate

Cat.No: T20802

Synonym: Locacorten,NSC-107680,特戊酸氟米松,Lorinden,NSC 107680,NSC107680,Locorten

Target: Others

Dehydronitrosonisoldipine

Cat.No: T10991

Target: Calcium Channel

Cat.No: TQ0125

Synonym: BAY 68-4986,卡帕诺生

Target: Adenosine Receptor

Fludrocortisone

Cat.No: T1666L

Synonym: 9α-fluorocortisol,9α-Fludrocortisone,Florinef,9α-fluorohydrocortisone,氟氢可的松,Fludrocortisone acetate,Astonin,9α-Fluorcortisol

Target: Others

Fludrocortisone acetate

Cat.No: T1666

Synonym: 9α-Fluorcortisol acetate,9α-Fludrocortisone acetate,醋酸氟氢可的松,9α-fluorocortisol acetate

Target: Glucocorticoid Receptor, Autophagy

Cat.No: T2526

Synonym: Zetonna,环索奈德,RPR251526,Omnaris,Alvesco

Target: Glucocorticoid Receptor

Hydrocortisone 17-butyrate

Cat.No: T0270

Synonym: 丁酸氢化可的松,Cortisol 17-butyrate,Hydrocortisone butyrate

Target: Glucocorticoid Receptor, Annexin A, Adrenergic Receptor

Isonicotinamide

Cat.No: T0552

Target: Others

Cat.No: T21899

Synonym: SR-1354,SR1354,Ro 7-0582

Target: GPX

Cat.No: T28748

Synonym: RG14202,DTI0009,DTI-0009,RG-14202,DT-009,DT009

Target: Adenosine Receptor

Cat.No: T68087

Target: Others

Prednisone acetate

Cat.No: T8396

Synonym: Prednisone 21-acetate,醋酸泼尼松

Target: Glucocorticoid Receptor

Tolperisone hydrochloride

Cat.No: T0511

Synonym: 盐酸托哌酮,Muscalm,Midocalm,托哌酮盐酸盐,Tolperisone HCl

Target: Sodium Channel

Cat.No: T0094

Synonym: Entocort,Pulmicort,布地奈德,Rhinocort

Target: Glucocorticoid Receptor

Cat.No: T8777

Synonym: 倍氯米松,BecloMethasone

Target: Glucocorticoid Receptor

Clobetasone butyrate

Cat.No: T14981

Target: Glucocorticoid Receptor

Hydrocortisone hemisuccinate

Cat.No: T4602

Synonym: Hydrocortisone 21-he,氢化可的松琥珀酸酯,hydrocortisone 21-hemisuccinate*free acid,Hydrocortisone 21-hemisuccinate

Target: Glucocorticoid Receptor, Others, Interleukin

Hydrocortisone Valerate

Cat.No: T0276

Synonym: Westcort,氢化可的松戊酸酯

Target: Glucocorticoid Receptor

Cat.No: T1124

Synonym: 氟米松,Flumetasone,RS-2177,NSC-54702

Target: Glucocorticoid Receptor

pyridoxal isonicotinoyl hydrazone

Cat.No: T5314

Synonym: 吡哆醛异烟酰肼,PIH

Target: Others

Silperisone HCl

Cat.No: T28778

Synonym: RGH5002,SILA336,RGH-5002,Silperisone hydrochloride,SILA-336

Cat.No: T6884

Synonym: 2-Cl-IB-MECA,CF-102

Target: Adenosine Receptor

Cat.No: T76828

Synonym: LT 1009

Target: LPL Receptor

Isonipecotic acid

Cat.No: T22348

Synonym: 4-Piperidinecarboxylic acid,Hexahydroisonicotinic acid,4-哌啶甲酸,4-Carboxypiperidine

Target: GABA Receptor

Dexamethasone 9,11-epoxide

Cat.No: T19277

Target: Others

Cat.No: T34685

Synonym: MRE-0094,MRE0094,MRE 0094

Dexamethasone Sodium Phosphate

Cat.No: T6465

Synonym: Dexadreson,地塞米松磷酸钠,Dexagro,Dalalone

Target: IL Receptor, COX

Cat.No: T7188

Synonym: CF-101,IB-MECA

Target: Apoptosis, Adenosine Receptor

Sonidegib diphosphate

Cat.No: T15727

Synonym: NVP-LDE 225 diphosphate,Erismodegib diphosphate,LDE225 diphosphate

Target: Smo

Cat. No.	Product Name	Target	Signaling Pathways
T13822	Podecdysone B	Others	Others
	Podecdysone B 是一种从露水草中分离出来的植物蜕皮激素。
TN2277	Torachrysone-8-O-b-D-glucoside 芦荟大黄素 8-葡萄糖甙,Torachrysone 8-O-glucoside	Antifection	Microbiology/Virology
	Torachrysone-8-O-b-D-glucoside 可从 Polygonum multiflorum 分离得到。它对 DPCs(真皮乳头细胞)的增殖具有促进作用。
TN6797	Isoneochamaejasmin A	Others	Others
	Isoneochamaejasmin A 是一种双黄酮类化合物，是一种广泛使用的中药 stellera chamaejasme L. 干燥根中的主要活性成分之一。
Fr13756	Isonicotinic acid	Endogenous Metabolite; Drug Metabolite	Metabolism
	Isonicotinic acid 是 Isoniazid 的代谢产物。Isoniazid 通过肼解转化为 Isonicotinic acid。 Isoniazid 向 Isonicotinic acid 的生物转化可以通过细胞色素 P450 酶催化。
T0269	Dichlorisone Acetate 糊状叶绿素,Diloderm,醋酸二氯松	Endogenous Metabolite; AChE	Metabolism; Neuroscience
	Dichlorisone Acetate (Diloderm) 一种是合成的糖皮质激素皮质类固醇，具有抗炎特性。
TN1216	2-O-Acetyl-20-hydroxyecdysone 20-Hydroxyeedysone 2-acetate	Beta Amyloid; Others	Neuroscience; Others
	2-O-Acetyl-20-hydroxyecdysone 是存在于昆虫和陆生植物中的一种蜕皮激素，2-O-Acetyl-20-hydroxyecdysone 对 amyloid-β42 诱导的细胞毒性有抑制作用，能够通过促进纤维发生减少 Aβ 寡聚物的形成，将 Aβ 寡聚物转变为低毒性纤维。
TN7250	Torachrysone Triglucoside 1-[8-[(O-β-D-Glucopyranosyl-(1→3)-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl)oxy]-1-hydroxy-6-methoxy-3-methyl-2-naphthalenyl]ethanone	Others	Others
	Torachrysone Triglucoside 是从决明子种子中分离出来的葡萄糖苷具有潜在的抗肿瘤活性。
TN7248	Torachrysone tetraglucoside	Antioxidant; Antifungal	Microbiology/Virology; oxidation-reduction
	Torachrysone tetraglucoside 是从豆科植物决明子中分离得到的酚苷，具有抗氧化和抗菌活性。
T3008	Lawsone methyl ether 2-Methoxy-1,4-naphthoquinone,2-Methoxy-p-naphthoquinone,2-Methoxynaphthoquinone,2-甲氧基-1,4-萘并醌	Apoptosis; Antibacterial; Antifungal	Apoptosis; Microbiology/Virology
	Lawsone methyl ether (2-Methoxy-1,4-naphthoquinone) 是从凤仙花和Swertia calycina 中分离出的，有抗真菌和抗菌活性。
T3323	Ursonic Acid CCRIS 7123,NSC4060,熊果酮酸,Prunol,3-Ketoursolic acid,Malol,TOS-BB-0966	Apoptosis; HIV Protease; Endogenous Metabolite	Apoptosis; Metabolism; Microbiology/Virology; Proteases/Proteasome
	Ursonic Acid (TOS-BB-0966) 是一种天然三萜酸，属于熊果烷三萜类，其结构基于五环熊果烷骨架。它具有作为 HIV-1 蛋白酶抑制剂的潜力。
T5S1882	Songorine 准葛尔乌头碱,Napellonine,Zongorine,Bullatine G	Others; GABA Receptor	Membrane transporter/Ion channel; Neuroscience; Others
	Songorine (Napellonine) 是从乌头属中分离出的一种二萜生物碱，具有抗癌、抗心律不齐和抗炎活性。它是大鼠脑中的GABAA 受体拮抗剂，有用于上皮性卵巢癌的研究潜力。
T0034	Cortisone acetate 醋酸可的松,Cortisone 21-acetate,NSC 49420	Glucocorticoid Receptor; Endogenous Metabolite	Endocrinology/Hormones; Metabolism
	Cortisone acetate (NSC-49420) 是 Cortisol(一种糖皮质激素)的氧化代谢产物。它在高浓度下能够部分干预 Glucocorticoid 与Glucocorticoid-receptor 的结合。它具有免疫抑制和消炎的作用。
T2884	Cortisone Kendall's compound E,17-Hydroxy-11-dehydrocorticosterone,可的松	Glucocorticoid Receptor; Endogenous Metabolite	Endocrinology/Hormones; Metabolism
	Cortisone (17-Hydroxy-11-dehydrocorticosterone) 是 Cortisol(一种糖皮质激素)的氧化代谢产物。Cortisone 具有消炎和免疫抑制的作用。Cortisone 在高浓度下对 Glucocorticoid 与Glucocorticoid-receptor 的结合具有部分干预作用。
T1243	Hydrocortisone acetate Cortisol 21-acetate,Hydrocortisone 21-acetate,醋酸氢化可的松	Glucocorticoid Receptor; Annexin A; Endogenous Metabolite	Endocrinology/Hormones; GPCR/G Protein; Metabolism
	Hydrocortisone acetate (Cortisol 21-acetate) 是皮质类固醇，能够减少轻微皮肤刺激或痔疮引起的肿胀、搔痒和疼痛。
T19117	3-Deoxyglucosone 3-Deoxy-D-glucosone,2-keto-3-Deoxyglucose	GPX; Glucagon Receptor	GPCR/G Protein; oxidation-reduction
	3-Deoxyglucosone(3-Deoxy-D-glucosone) 是美拉德反应和多元醇反应的中间体途径合成。3-Deoxyglucosone 与蛋白质氨基快速反应形成晚期糖基化末端蛋白 (AGEs)。3-Deoxyglucosone 可使谷胱甘肽过氧化物酶失活，可与低葡萄糖协同作用以增强 GLP-1 分泌，可以作为糖尿病生物学检测的标志物。
TN7253	Torachrysone gentiobioside
	Torachrysone gentiobioside 是一种从决明子中分离出来的酚苷类化合物。
T3246	Tabersonine (-)-Tabersonine,Tabersonin,水甘草碱,它勃宁, 柳叶水甘草碱	Others	Others
	Tabersonine (Tabersonin) 是从蔷薇中分离出的吲哚类生物碱。它能破坏 Aβ(1-42) 的聚合，并改善 Aβ 聚合诱导的细胞毒性。它具有抗炎作用，可用于研究 ALI/ARDS。
T2881	Crustecdysone Commisterone,B-ecdysone,Commisterone,20-Hydroxyecdysone,Ecdysterone,B-ecdysone,β-蜕皮甾酮,Hydroxyecdysone,羟基蜕皮激素	Others; Caspase; Endogenous Metabolite; Autophagy	Apoptosis; Autophagy; Metabolism; Others; Proteases/Proteasome
	Crustecdysone (Hydroxyecdysone) 是来源于露水草的一种蜕皮激素，可调节昆虫的蜕皮或蜕皮过程。它是 Ecdysone 的活性代谢物，通过 20E 核受体复合物 EcR-USP 抑制半胱天冬酶活性并诱导自噬，在心血管系统中具有调节或保护作用。
T1168	Desonide Tridesilon,地索奈德,Locapred,Prednacinolone	Glucocorticoid Receptor	Endocrinology/Hormones
	Desonide (Prednacinolone) 是一种非氟化皮质类固醇抗炎剂，能够作用于糖皮质激素受体。
T13500	3-O-Acetyl-20-Hydroxyecdysone	Others	Others
	3-O-Acetyl-20-Hydroxyecdysone 是分离自Cyanotis arachnoidea C.B.Clark 根中的类固醇。
T5810	TABERSONINE HYDROCHLORIDE 水甘草碱盐酸盐,它波宁盐酸盐	Beta Amyloid	Neuroscience
	Tabersonine hydrochloride 是分离自蔷薇中的一种吲哚类生物碱，具有抗炎活性，可用于 ALI/ARDS 的研究。Tabersonine 能破坏 Aβ(1-42) 的聚合和改善 Aβ 聚集诱导的细胞毒性。
T3901	Solasonine	Others	Others
	Solasonine 是一种甾体糖苷生物碱，从龙葵中分离获得，对人胃癌细胞有细胞毒性。
T1614	Hydrocortisone 氢化可的松,Cortisol	Glucocorticoid Receptor; Endogenous Metabolite	Endocrinology/Hormones; Metabolism
	Hydrocortisone (Cortisol) 是一种糖皮质激素，由肾上腺素皮质分泌。Hydrocortisone 激动糖皮质激素受体，可促进蛋白质分解代谢、糖异生、毛细血管壁稳定性、肾脏钙排泄，并抑制免疫和炎症反应。
T82692	Comosone II
	Comosone II (化合物4)，一种从姜黄(Curcuma zedoaria)分离的化合物，展现中度抗增殖活性。对于Ca Ski癌细胞，其IC50值为76 μg/mL，显示其对癌细胞生长的抑制作用。
T39219	Ficusonolide
	Ficusonolide exhibits significant antidiabetic activity through its interactions with dipeptidyl peptidase-IV (DPP-IV), protein tyrosine phosphatase 1B (PTP-1B), α-glucosidase, and α-amylase.
TN2278	Torachrysone 决明柯酮	Antifection	Microbiology/Virology
	Torachrysone shows promising antioxidant activity. Torachrysone, toralactone , aloe-emodin, rhein and emodin show noticeable antibacterial effects on four strains of methicillin-resistant Staphylococcus aureus with a minimum inhibitory concentration of 2-
T25775	Mansonone E
	Mansonone E is a topoisomerase II inhibitor with cytotoxic and topo inhibitory potencies.
TN4504	Massoniresinol	Others	Others
	Massoniresinol是一种天然产物，属于八角科八角属，其产品编号为 TN4504，CAS号为 96087-10-4。Massoniresinol可用作对照参考。
T36954	Nemorosone
	Nemorosone is a polycyclic polyprenylated acylphloroglucinol (PPAP) originally isolated from C. rosea that has antiproliferative properties.1 Nemorosone inhibits growth of NB69, Kelly, SK-N-AS, and LAN-1 neuroblastoma cells (IC50s = 3.1-6.3 μM), including several drug-resistant clones, but not MRC-5 human embryonic fibroblasts (IC50 = >40 μM).2 It increases DNA fragmentation in LAN-1 cells in a dose-dependent manner, and decreases N-Myc protein levels and phosphorylation of ERK1/2 by MEK1/2. Nem...
T38477	Isonaringin
	Isonaringin shows anti-Alzheimer’s activity by inhibiting AChE.
T19116	3-Deoxy-galactosone	Others	Others
	3-Deoxy-galactosone is a 1,2-dicarbonyl compound from the degradation of galactose. It is formed in food during Maillard and caramelization reactions.
TN6221	Sonderianol
	Sonderianol 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN6221，CAS号为 85563-65-1。
TN2188	Schisanwilsonin B Schisanwilsonin I,鹤庆五味子素 B	Others	Others
	Schisanwilsonin D, and schisantherin C show anti-HBV activity.
TN6173	Rhodomyrtosone I
	Rhodomyrtosone I 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN6173，CAS号为 1402725-98-7。
TN2187	Schisanwilsonin C Schisanwilsonin H,鹤庆五味子素 C	Others	Others
	Schisanwilsonin H is a natural product
TN3887	Dodovisone B	Others	Others
	Dodovisone B is a natural product from Dodonaea viscosa.
TN5734	Sampsone B
	Sampsone B 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN5734，CAS号为 1309125-17-4。
TN3539	Broussonin A	ERK; IL Receptor; IκB/IKK; NOS; NF-κB; Akt	Cytoskeletal Signaling; Immunology/Inflammation; MAPK; NF-κB; PI3K/Akt/mTOR signaling
	Broussonins A and B, new phytoalexins from diseased paper mulberry. Broussonin A shows estrogenic activity with ligand-binding activity of estrogen receptor, transcriptional activity of estrogen-responsive element-luciferase reporter genes. Broussonin A c
TN5655	Broussonin B
	Broussonins A and B, new phytoalexins from diseased paper mulberry. Broussonin B can induce neurite outgrowth in PC-12 cells at concentration of 50 microg/ml, and show moderate inhibitory activities against a chymotrypsin-like activity of the proteasome.B
TN3832	Deoxyflindissone	Others	Others
	Deoxyflindissone exhibits significant cytotoxic activity against the A549, SK-OV-3, SK-MEL-2, and XF498 cell lines.
TN3541	Broussonin E	ERK; p38 MAPK; TNF; JAK; STAT	Angiogenesis; Apoptosis; Chromatin/Epigenetic; JAK/STAT signaling; MAPK; Stem Cells
	Broussonin E could suppress inflammation by modulating macrophages activation state via inhibiting the ERK and p38 MAPK and enhancing JAK2-STAT3 signaling pathway, and can be further developed as a promising drug for the treatment of inflammation-related
TN2344	Swainsonine Tridolgosir	Apoptosis; Others; Antibiotic	Apoptosis; Microbiology/Virology; Others
	Swainsonine (Tridolgosir) 是一种从黄芪中分离出来的一种生物碱，是一种强效和可逆的α-甘露糖苷酶抑制剂。Swainsonine 具有抗肿瘤活性，可诱导细胞凋亡和细胞周期停滞在 G2/M 期。
TN4314	Isonardoperoxide	Antifection	Microbiology/Virology
	Isonardoperoxide shows strong antimalarial activity against Plasmodium falciparum malaria (6.0 × 10-7 M).
TN1250	3-Epiwilsonine	Others	Others
	3-Epiwilsonine是一种天然产物，属于三尖杉科三尖杉属，其产品编号为 TN1250，CAS号为 39024-15-2。3-Epiwilsonine可用作对照参考。
T40796	5β-Dihydrocortisone
	5β-Dihydrocortisone is a sterol metabolite of cortisone by 5β-reductase (AKR1D1) in liver.
TN4395	Kobusone	Others	Others
	Kobusone是一种天然产物，属于莎草科莎草属，其产品编号为 TN4395，CAS号为 24173-71-5。Kobusone可用作对照参考。
TN5378	Axinysone A (-)-Axinysone A
	Axinysone A 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN5378，CAS号为 1114491-57-4。
TN4316	Isonormangostin	Others	Others
	Isonormangostin是一种天然产物，属于藤黄科藤黄属，其产品编号为 TN4316，CAS号为 15404-80-5。Isonormangostin可用作对照参考。
T2969	Lawsone Hennotannic acid,指甲花醌,2-hydroxy-1,4-naphthoquinone	Others; Antifungal	Microbiology/Virology; Others
	Lawsone (Hennotannic acid) 是一种从Lawsonia inermis 的叶片中分离得到的萘醌染料，具有抗菌和抗氧化活性。
TN6592	Isonemerosin
	Isonemerosin 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN6592，CAS号为 181524-79-8。
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天然产物

Cat.No: T13822

Target: Others

Torachrysone-8-O-b-D-glucoside

Cat.No: TN2277

Synonym: 芦荟大黄素 8-葡萄糖甙,Torachrysone 8-O-glucoside

Target: Antifection

Isoneochamaejasmin A

Cat.No: TN6797

Target: Others

Isonicotinic acid

Cat.No: Fr13756

Target: Endogenous Metabolite, Drug Metabolite

Dichlorisone Acetate

Cat.No: T0269

Synonym: 糊状叶绿素,Diloderm,醋酸二氯松

Target: Endogenous Metabolite, AChE

2-O-Acetyl-20-hydroxyecdysone

Cat.No: TN1216

Synonym: 20-Hydroxyeedysone 2-acetate

Target: Beta Amyloid, Others

Torachrysone Triglucoside

Cat.No: TN7250

Synonym: 1-[8-[(O-β-D-Glucopyranosyl-(1→3)-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl)oxy]-1-hydroxy-6-methoxy-3-methyl-2-naphthalenyl]ethanone

Target: Others

Torachrysone tetraglucoside

Cat.No: TN7248

Target: Antioxidant, Antifungal

Lawsone methyl ether

Cat.No: T3008

Synonym: 2-Methoxy-1,4-naphthoquinone,2-Methoxy-p-naphthoquinone,2-Methoxynaphthoquinone,2-甲氧基-1,4-萘并醌

Target: Apoptosis, Antibacterial, Antifungal

Cat.No: T3323

Synonym: CCRIS 7123,NSC4060,熊果酮酸,Prunol,3-Ketoursolic acid,Malol,TOS-BB-0966

Target: Apoptosis, HIV Protease, Endogenous Metabolite

Cat.No: T5S1882

Synonym: 准葛尔乌头碱,Napellonine,Zongorine,Bullatine G

Target: Others, GABA Receptor

Cortisone acetate

Cat.No: T0034

Synonym: 醋酸可的松,Cortisone 21-acetate,NSC 49420

Target: Glucocorticoid Receptor, Endogenous Metabolite

Cat.No: T2884

Synonym: Kendall's compound E,17-Hydroxy-11-dehydrocorticosterone,可的松

Target: Glucocorticoid Receptor, Endogenous Metabolite

Hydrocortisone acetate

Cat.No: T1243

Synonym: Cortisol 21-acetate,Hydrocortisone 21-acetate,醋酸氢化可的松

Target: Glucocorticoid Receptor, Annexin A, Endogenous Metabolite

3-Deoxyglucosone

Cat.No: T19117

Synonym: 3-Deoxy-D-glucosone,2-keto-3-Deoxyglucose

Target: GPX, Glucagon Receptor

Torachrysone gentiobioside

Cat.No: TN7253

Cat.No: T3246

Synonym: (-)-Tabersonine,Tabersonin,水甘草碱,它勃宁, 柳叶水甘草碱

Target: Others

Cat.No: T2881

Synonym: Commisterone,B-ecdysone,Commisterone,20-Hydroxyecdysone,Ecdysterone,B-ecdysone,β-蜕皮甾酮,Hydroxyecdysone,羟基蜕皮激素

Target: Others, Caspase, Endogenous Metabolite, Autophagy

Cat.No: T1168

Synonym: Tridesilon,地索奈德,Locapred,Prednacinolone

Target: Glucocorticoid Receptor

3-O-Acetyl-20-Hydroxyecdysone

Cat.No: T13500

Target: Others

TABERSONINE HYDROCHLORIDE

Cat.No: T5810

Synonym: 水甘草碱盐酸盐,它波宁盐酸盐

Target: Beta Amyloid

Cat.No: T3901

Target: Others

Cat.No: T1614

Synonym: 氢化可的松,Cortisol

Target: Glucocorticoid Receptor, Endogenous Metabolite

Cat.No: T82692

Cat.No: T39219

Cat.No: TN2278

Synonym: 决明柯酮

Target: Antifection

Cat.No: T25775

Cat.No: TN4504

Target: Others

Cat.No: T36954

Cat.No: T38477

3-Deoxy-galactosone

Cat.No: T19116

Target: Others

Cat.No: TN6221

Schisanwilsonin B

Cat.No: TN2188

Synonym: Schisanwilsonin I,鹤庆五味子素 B

Target: Others

Rhodomyrtosone I

Cat.No: TN6173

Schisanwilsonin C

Cat.No: TN2187

Synonym: Schisanwilsonin H,鹤庆五味子素 C

Target: Others

Cat.No: TN3887

Target: Others

Cat.No: TN5734

Cat.No: TN3539

Target: ERK, IL Receptor, IκB/IKK, NOS, NF-κB, Akt

Cat.No: TN5655

Deoxyflindissone

Cat.No: TN3832

Target: Others

Cat.No: TN3541

Target: ERK, p38 MAPK, TNF, JAK, STAT

Cat.No: TN2344

Synonym: Tridolgosir

Target: Apoptosis, Others, Antibiotic

Isonardoperoxide

Cat.No: TN4314

Target: Antifection

Cat.No: TN1250

Target: Others

5β-Dihydrocortisone

Cat.No: T40796

Cat.No: TN4395

Target: Others

Cat.No: TN5378

Synonym: (-)-Axinysone A

Isonormangostin

Cat.No: TN4316

Target: Others

Cat.No: T2969

Synonym: Hennotannic acid,指甲花醌,2-hydroxy-1,4-naphthoquinone

Target: Others, Antifungal

Cat.No: TN6592

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