首页工具

3-Deoxyglucosone

产品编号 T19117 CAS 4084-27-9

别名: 3-Deoxy-D-glucosone, 2-keto-3-Deoxyglucose

3-Deoxyglucosone(3-Deoxy-D-glucosone) 是美拉德反应和多元醇反应的中间体途径合成。3-Deoxyglucosone 与蛋白质氨基快速反应形成晚期糖基化末端蛋白 (AGEs)。3-Deoxyglucosone 可使谷胱甘肽过氧化物酶失活，可与低葡萄糖协同作用以增强 GLP-1 分泌，可以作为糖尿病生物学检测的标志物。

TargetMol的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

3-Deoxyglucosone, CAS 4084-27-9

规格	价格/CNY	货期
1 mg	￥ 1,930	现货
5 mg	￥ 4,820	现货
10 mg	￥ 6,690	现货
50 mg	特惠询价	待询

大包装超大折扣，点击咨询

选择批次

更多批次查询请联系客服

生物活性

化学信息

存储 & 溶解度

参考文献

相关产品

产品描述	3-Deoxyglucosone(3-Deoxy-D-glucosone) is synthesized by the intermediate pathway of the melad and polyol reactions.3-Deoxyglucosone reacts rapidly with protein amino groups to form advanced glycosylated end proteins (AGEs).3-Deoxyglucosone inactivates glutathione peroxidase and synergizes with low glucose to enhance GLP-1 secretion.3-Deoxyglucosone is used as a biomarker for diabetes mellitus.3-Deoxyglucosone has been shown to be an inhibitor of GLP-1 secretion in the presence of low glucose. 3-Deoxyglucosone inactivates glutathione oxidase, synergizes with low glucose to enhance GLP-1 secretion, and can be used as a biologic marker for diabetes.
体外活性	3-Deoxyglucosone (80 ng/ml-1000 ng/ml; 1 hour; STC-1 cells) induces a noteworthy 1.23-fold increase in GLP-1 secretion specifically in the 300 ng/ml and 1000 ng/ml 3DG-treated groups. However, at a lower concentration of 80 ng/ml, no discernible effects are observed. Notably, 3-Deoxyglucosone at 300 ng/ml significantly elevates intracellular Ca2+ levels, as determined by Fluo-3/AM (2.5 μM for 30 mins). In contrast, 3DG does not impact intracellular cAMP levels in a cAMP Elisa assay. Furthermore, at a concentration of 300 ng/ml, 3-Deoxyglucosone significantly enhances the protein expression levels of TAS1R2, TAS1R3, and TRPM5 under both glucose-free and high conditions.[1]
体内活性	3-Deoxyglucosone (20 mg/kg; intragastric administration; single dose) induces a deterioration in glucose tolerance, as evidenced by an increased Area Under the Curve (AUC). Plasma glucagon levels do not show significant differences. The administration of 3-Deoxyglucosone leads to the development of impaired glucose regulation (IGR) accompanied by evident dysfunction of pancreatic islet cells in both Kunming mice and SD rats.[2] 3-deoxyglucosone (5-50 mg/kg; gastric gavage; once daily; 2 weeks; SD rats) exhibits significant increases in the upper small intestine (1.4-fold), lower small intestine (1.4-fold), ileum (1.4-fold), and colon (two-fold) compared to basal levels in their respective control groups. Additionally, there is a noteworthy decrease in the protein expressions of TAS1R2, TAS1R3, and TRPM5 observed in both the duodenum and colon.[3]
细胞实验	Cell Line: STC-1 cells. Concentration: 300?ng/ml. Incubation Time: 1 hour [1]
动物实验	Animal Model: SD rats. Dosage: 5, 20 and 50 mg/kg. Administration: oral administration; once daily; 2 weeks [3]

别名	3-Deoxy-D-glucosone, 2-keto-3-Deoxyglucose
分子量	162.14
分子式	C6H10O5
CAS No.	4084-27-9

存储

store at low temperature　|　Powder: -20°C for 3 years | In solvent: -80°C for 1 year

计算器

摩尔浓度计算器

稀释计算器

配液计算器

分子量计算器

质量

浓度

容积

分子量

浓度 (起始)

容积 (起始)

浓度 (终)

容积 (终)

溶液体积

质量

配液浓度

参考文献

1. Song X, et al. 3-Deoxyglucosone Induces Glucagon-Like Peptide-1 Secretion from STC-1 Cells via Upregulating Sweet Taste Receptor Expression under Basal Conditions.Int J Endocrinol. 2019 Oct 23;2019:4959646. 2. Wang F, et al. Acute Reduction of Incretin Effect and Glucose Intolerance in Rats by Single Intragastric Administration of 3-deoxyglucosone. Exp Clin Endocrinol Diabetes. 2017 Jan;125(1):4-11. 3. Zhang L, et al. Accumulation of intestinal tissue 3-deoxyglucosone attenuated GLP-1 secretion and its insulinotropic effect in rats. Diabetol Metab Syndr. 2016 Nov 29;8:78. 4. Niwa T, et al. 3-Deoxyglucosone: metabolism, analysis, biological activity, and clinical implication.J Chromatogr B Biomed Sci Appl. 1999 Aug 6;731(1):23-36.

剂量换算

对于不同动物的给药剂量换算，您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10 只，您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL)，如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法：取 50 μL DMSO 主液，加入 300 μL PEG300，混匀澄清，再加 50 μL Tween 80，混匀澄清，再加 600 μL ddH2O, 混匀澄清。

第一步：请输入动物实验的基本信息

剂量

mg/kg

每只动物体重

给药体积

μL

动物数量

第二步：请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。

% DMSO+

% +