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35

抑制剂 & 化合物

40

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T7704	KY-226	Phosphatase	Metabolism
	KY-226 是选择性的，口服活性的和变构蛋白酪氨酸磷酸酶 1B 抑制剂，IC50=0.25 μM，且不激活 PPARγ 。它可以保护神经元免受脑缺血损伤。它通过增强胰岛素和瘦素信号传导发挥抗糖尿病和抗肥胖作用。
T8476	RSVA405 RSVA 405	AMPK; STAT; Autophagy	Autophagy; Chromatin/Epigenetic; JAK/STAT signaling; PI3K/Akt/mTOR signaling; Stem Cells
	RSVA405 是一种具有口服活性的AMPK 激活剂，EC50值为 1 μM。它也是一种 STAT3 抑制剂，具有抗炎作用，可研究肥胖症。它通过促进 CaMKKβ 依赖的 AMPK 活化，从而抑制mTOR，并促进自噬以增加 Aβ 的降解。
T3283	Cetilistat 新利司他,ATL-962	Lipid	Metabolism
	Cetilistat (ATL-962) 是胰腺脂肪酶 (pancreatic lipase) 抑制剂，能够抑制大鼠脂肪酶(IC50:54.8 nM)和人胰脂肪酶(IC50:5.95 nM)的活性，可用作有效的抗肥胖药。
T0839	Ketoprofen 酮基布洛芬,RP-19583,酮洛芬	Apoptosis; COX; MRP	Apoptosis; Immunology/Inflammation; Neuroscience
	Ketoprofen (RP-19583) 是一种非甾体抗炎剂，能够有效地抑制COX 的活性，在人血单核细胞中，对 COX-1 和 COX-2 的IC50值分别为 2 nM 和 26 nM。
T0686	Orlistat Ro-18-0647,奥利司他,Tetrahydrolipstatin	Apoptosis; Others; Fatty Acid Synthase	Apoptosis; Metabolism; Others
	Orlistat (Tetrahydrolipstatin) 是一种不可逆的胰腺和胃脂肪酶抑制剂，也是一种脂肪酸合成酶抑制剂，可研究肥胖症，具有抗动脉粥样硬化作用。
T1824	TGR5 Receptor Agonist	GPCR19	GPCR/G Protein
	TGR5 Receptor Agonist 是一种TGR5(GPCR19)激动剂。
T11990	Meclofenamic acid 甲氯芬那酸,Meclofenamate	Others; Gap Junction Protein	Cytoskeletal Signaling; Others
	Meclofenamic acid (Meclofenamate) 是一种非特异性 gap-junction 阻滞剂和特异性脂肪量和肥胖相关 (FTO) 酶抑制剂。 Meclofenamic acid 具有抗炎活性。
T39189	3,4,5-Trihydroxycinnamic acid decyl ester
	3,4,5-Trihydroxycinnamic acid decyl ester, an effective inhibitor of lipid absorption and accumulation, exhibits anti-obesity properties. Additionally, this compound acts as a pancreatic lipase inhibitor, with an EC 50 of around 0.9 μM.
T7815L	AOD9604 acetate(221231-10-3 free base) AOD-9604 acetate,AOD9604 acetate,AOD 9604 acetate	Others	Others
	AOD9604 acetate(221231-10-3 free base) 是一种基于人类生长激素的潜在抗肥胖肽。
T13169	TM-25659	Others	Others
	TM-25659是一种具有 PDZ 结合图案的转录协同激活剂（TAZ）的调节剂，具有抗骨质疏松和抗肥胖的活性。
T12400	Peliglitazar racemate (Rac)-Peliglitazar,(Rac)-BMS 426707-01,BMS 426707-01 racemate	PPAR	DNA Damage/DNA Repair; Metabolism
	Peliglitazar racemate(BMS 426707-01 racemate) 是 Peliglitazar 的外消旋体。Peliglitazar racemate 可作为潜在的抗糖尿病和抗肥胖剂。
T11016	DGAT-1 inhibitor 2	Transferase	Metabolism
	DGAT-1 inhibitor 2是有效的DGAT-1抑制剂，具有减肥功效。
T13332	(Rac)-WAY-161503	5-HT Receptor	GPCR/G Protein; Neuroscience
	(Rac)-WAY-161503 是一种有效的，选择性的，高亲和力的 5-HT2C 受体激动剂，Ki 为 4 nM，EC50 为 12 nM。(Rac)-WAY-161503 对 HT2C 的亲和力分别比 5-HT2A 和 5-HT2B 受体高。(Rac)-WAY-161503 具有抗肥胖和抗抑郁的作用。
T30140	Arotinolol hydrochloride Arotinolol HCl	5-HT Receptor; Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Arotinolol hydrochloride（Arotinolol HCl）是一种非选择性的 α/β-肾上腺素受体 (α/β-adrenergic receptor ) 阻滞剂。Arotinolol hydrochloride 对放射性配体 125I-ICYP 与 5HT1B-羟色胺受体能结合有抑制作用。Arotinolol hydrochloride 是一种抗高血压和抗肥胖试剂，可改善大鼠主动脉僵硬，研究肥胖相关疾病。
T13289	EHP-101 VCE-004.8	Cannabinoid Receptor; HIF/HIF Prolyl-Hydroxylase; PPAR	Chromatin/Epigenetic; DNA Damage/DNA Repair; GPCR/G Protein; Metabolism
	EHP-101 (VCE-004.8) 是一种口服有效的特异性PPARγ和CB2受体双重激动剂，可抑制脯氨酰-羟化酶(PHDs) 并激活HIF 通路。它是一种半合成的多靶点大麻喹啉，可减弱脂肪生成并防止饮食诱导的肥胖，具有抗炎活性。
T1519L	Rimonabant SR141716,利莫那班	Cannabinoid Receptor; Antibacterial; Acyltransferase	GPCR/G Protein; Metabolism; Microbiology/Virology
	Rimonabant (SR141716) 是一种选择性的、能透过血脑屏障的中心大麻素受体 1 拮抗剂， Ki 值为 1.8 nM。它也能够抑制分枝杆菌膜蛋白 3。
T8732	CTPI-2	Others; Mitochondrial Metabolism	Metabolism; Others
	CTPI-2 是一种特异性线粒体柠檬酸盐载体SLC25A1抑制剂，KD=3.5 μM，具有抗肿瘤作用。它能够抑制糖酵解、PPARγ 及其下游靶点葡萄糖转运蛋白 GLUT4。它阻断非酒精性脂肪性肝炎逆转脂肪变性的显著改变，防止演变为脂肪性肝炎，减少肝脏和脂肪组织中炎性巨噬细胞的浸润，并显著减轻由高脂肪饮食引起的肥胖。
T25108	ARL 15849XX ARL15849XX,FPL15849,FPL-15849,FPL 15849,ARL-15849XX
	ARL 15849XX, a CCK-8 analog, is a novel anti-obesity agent.
T31060	CP-472555 UNII-6T0KV7024R,CP 472555,CP472555
	CP-472555 is a selective nonsteroidal glucocorticoid receptor antagonist with anti-GR and anti-obesity activity in animal models.
T33019	LY-79771 free base LY 79771,LY79771,LY-79771
	LY-79771 is a phenylethanolamine anti-obesity agent, which can effectively prevent fat recovery after energy deprivation.
T71859	Amidinomalonamide hydrochloride
	Amidinomalonamide hydrochloride is a chemical reagent used in the preparation of pyrimidooxazines used as DGAT1 inhibitors. This drug has potential use as an anti-obesity treatment.
T63213	Human enteropeptidase-IN-2
	Human enteropeptidase-IN-2 是肠肽酶 (enteropeptidase) 的高效抑制剂，能够用于研究抗肥胖。
T61152	FTO-IN-8
	FTO-IN-8, also known as FTO-43, is an inhibitor of N6-methyladenosine demethylase FTO (fat mass- and obesity-associated protein). It exhibits an IC50 value of 5.5 μM and displays anti-cancer cell proliferative activity [1].
T16565	Ppc-1	Others	Others
	Ppc-1 is a chemical compound known for its inhibitory effects on the Gram-negative periodontopathogen Porphyromonas gingivalis. It acts as a mitochondrial uncoupler, enhancing mitochondrial oxygen consumption without affecting ATP production. Additionally, Ppc-1 serves as a cell-permeate inhibitor of interleukin-2 (IL-2). This compound exhibits various beneficial activities, including anti-obesity, antibacterial, and anti-inflammatory properties.
T73227	SH-BC-893
	SH-BC-893是一种具有口服活性的抗肿瘤鞘脂类似物，能够防止神经酰胺引起的线粒体功能障碍并纠正饮食引起的肥胖。适用于癌症和肥胖症的研究。
T77610	WAY-339495	Others	Others
	WAY-339495 可能具有抗肿瘤抗炎和镇痛活性，可用来研究肥胖、心血管疾病、糖尿病、神经退行性疾病、阿尔茨海默病和中风。
T70838	RO27-3225 TFA
	RO27-3225, also known as RO273225 is a melanocortin type 4 receptor agonist with EC50 = 1 nM. It may alleviate intestinal dysfuntion and brain damage. It has been investigated for an anti-obesity medication. Ro 27-3225 shows some activity at the MC1 receptor. Ro 27-3225 reverses hemorrhagic shock, reduces multiple organ damage, and improves survival.
T70660	Azalanstat HCl
	Azalanstat is an anti-obesity drug acting as a lanosterol 14α-demethylase inhibitor. Azalanstat has been shown to inhibit cholesterol synthesis in HepG2 cells, human fibroblasts, hamster hepatocytes and hamster liver, by inhibiting the cytochrome P450 enzyme lanosterol 14 alpha-demethylase. When administered orally to hamsters fed regular chow, RS-21607 (50 mg/kg/day) lowered serum cholesterol in a dose-dependent manner (ED50 = 62 mg/kg) in a period of 1 week. It preferentially lowered low densi...
T76315	HKPao
	HKPao (Hunter-killer peptide ao) 是一种具有抗肥胖和抗肿瘤促凋亡活性的生物活性肽，能够促使细胞释放囊泡中的细胞色素 c。
T70661	Azalanstat mesylate
	Azalanstat is an anti-obesity drug acting as a lanosterol 14α-demethylase inhibitor. Azalanstat has been shown to inhibit cholesterol synthesis in HepG2 cells, human fibroblasts, hamster hepatocytes and hamster liver, by inhibiting the cytochrome P450 enzyme lanosterol 14 alpha-demethylase. When administered orally to hamsters fed regular chow, RS-21607 (50 mg/kg/day) lowered serum cholesterol in a dose-dependent manner (ED50 = 62 mg/kg) in a period of 1 week. It preferentially lowered low densi...
T35448	10-Thiastearic Acid
	Heteroatom-substituted fatty acids have been observed to modulate the extension and desaturating of fatty acids, and to influence their distribution within phospholipids pools. 10-Thiastearic acid inhibits desaturation of radiolabeled stearate to oleate in rat hepatocytes and hepatoma cells by more than 80% at a concentration of 25 μM. This activity is associated with a hypolipidemic effect, making this 10-thiastearic acid a useful tool for evaluating new anti-obesity therapeutics.
T60655	Resomelagon
	Resomelagon (AP1189) 是具有口服活性的有效黑素皮质素受体 (MR) 激动剂，可诱导Ca2+流动和 ERK1/2 磷酸化。Resomelagon 显示出抗炎活性，可用于研究肥胖和慢性炎症。
T62306	Human enteropeptidase-IN-1
	Human enteropeptidase-IN-1 (compound 6b) 是一种口服具有活力的、高效的、全身暴露量低的肠肽酶 (enteropeptidase) 抑制剂。Human enteropeptidase-IN-1 在饮食诱导肥胖 (DIO) 大鼠模型中具有促进粪便蛋白质输出的增加的作用，并且有效减轻体重。Human enteropeptidase-IN-1 能够用于研究抗肥胖。
T75893	CRF(6-33)(human) TFA
	CRF(6-33)(human) TFA 是一种 CRF 结合蛋白配体 (CRF-BP) 抑制剂，与CRF-BP 竞争性结合，但不与突触后 CRF 受体结合。CRF(6-33)(human) TFA 具有抗肥胖作用。
T35812	CAY10591 CAY10591
	Sirtuins (SIRTs) represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs). Human SIRT1 is the homolog of yeast silent information regulator 2 (Sir2) and has been shown to regulate the activity of the p53 tumor suppressor and inhibit apoptosis. Small molecule activators of SIRT1, such as resveratrol, extend lifespan in yeast and C. elegans in a manner that resembles caloric restriction. CAY10591 has been identified as an activator of the enzyme SIRT1. This com...

化合物

Cat.No: T7704

Target: Phosphatase

Cat.No: T8476

Synonym: RSVA 405

Target: AMPK, STAT, Autophagy

Cat.No: T3283

Synonym: 新利司他,ATL-962

Target: Lipid

Cat.No: T0839

Synonym: 酮基布洛芬,RP-19583,酮洛芬

Target: Apoptosis, COX, MRP

Cat.No: T0686

Synonym: Ro-18-0647,奥利司他,Tetrahydrolipstatin

Target: Apoptosis, Others, Fatty Acid Synthase

TGR5 Receptor Agonist

Cat.No: T1824

Target: GPCR19

Meclofenamic acid

Cat.No: T11990

Synonym: 甲氯芬那酸,Meclofenamate

Target: Others, Gap Junction Protein

3,4,5-Trihydroxycinnamic acid decyl ester

Cat.No: T39189

AOD9604 acetate(221231-10-3 free base)

Cat.No: T7815L

Synonym: AOD-9604 acetate,AOD9604 acetate,AOD 9604 acetate

Target: Others

Cat.No: T13169

Target: Others

Peliglitazar racemate

Cat.No: T12400

Synonym: (Rac)-Peliglitazar,(Rac)-BMS 426707-01,BMS 426707-01 racemate

Target: PPAR

DGAT-1 inhibitor 2

Cat.No: T11016

Target: Transferase

(Rac)-WAY-161503

Cat.No: T13332

Target: 5-HT Receptor

Arotinolol hydrochloride

Cat.No: T30140

Synonym: Arotinolol HCl

Target: 5-HT Receptor, Adrenergic Receptor

Cat.No: T13289

Synonym: VCE-004.8

Target: Cannabinoid Receptor, HIF/HIF Prolyl-Hydroxylase, PPAR

Cat.No: T1519L

Synonym: SR141716,利莫那班

Target: Cannabinoid Receptor, Antibacterial, Acyltransferase

Cat.No: T8732

Target: Others, Mitochondrial Metabolism

Cat.No: T25108

Synonym: ARL15849XX,FPL15849,FPL-15849,FPL 15849,ARL-15849XX

Cat.No: T31060

Synonym: UNII-6T0KV7024R,CP 472555,CP472555

LY-79771 free base

Cat.No: T33019

Synonym: LY 79771,LY79771,LY-79771

Amidinomalonamide hydrochloride

Cat.No: T71859

Human enteropeptidase-IN-2

Cat.No: T63213

Cat.No: T61152

Cat.No: T16565

Target: Others

Cat.No: T73227

Cat.No: T77610

Target: Others

Cat.No: T70838

Cat.No: T70660

Cat.No: T76315

Azalanstat mesylate

Cat.No: T70661

10-Thiastearic Acid

Cat.No: T35448

Cat.No: T60655

Human enteropeptidase-IN-1

Cat.No: T62306

CRF(6-33)(human) TFA

Cat.No: T75893

Cat.No: T35812

Synonym: CAY10591

Cat. No.	Product Name	Target	Signaling Pathways
T3672	Nomilin	MAPK	MAPK
	Nomilin 是一种柠檬苦素类化合物，从柑桔类提取物中获得，是抗肥胖症和降糖药。
T5751	Tigogenin	Others	Others
	Tigogenin 是甾体皂甙元，普遍用于甾体类药物的合成。它能够阻碍小鼠骨髓基质细胞脂肪细胞分化，促使成骨细胞的分化。
T5778	5,7-DIMETHOXYFLAVONE	Anti-infection; P450	Metabolism; Microbiology/Virology
	5,7-Dimethoxyflavone 是一种 Kaempferia parviflora 的主要成分，具有抗肿瘤、抗肥胖及抗炎活性。它对细胞色素 P450 (CYP) 3As 具有抑制作用，也是抗乳腺癌蛋白 (BCRP) 抑制剂。
T5583	Turanose 松二糖,D-(+)-Turanose	Endogenous Metabolite	Metabolism
	Turanose (D-(+)-Turanose) 是天然存在于蜂蜜中的蔗糖异构体。它具有抗炎和调节脂肪形成的活性。它具有肥胖症和相关慢性病的研究潜力。
T3675	1-Deoxynojirimycin Duvoglustat,Moranoline,1-脱氧野尻霉素,moranolin	PI3K; Glucosidase	Metabolism; PI3K/Akt/mTOR signaling
	1-Deoxynojirimycin (Moranoline) 是一种口服具有活性的 α-葡萄糖苷酶抑制剂。它具有降血糖、减肥和抗病毒的活性。它抑制餐后血糖，预防糖尿病。
TN3500	beta-Amyrone β-Amyron,β-香树脂酮	COX; AChR; PPAR; Antifection	DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Microbiology/Virology; Neuroscience
	beta-Amyrone (β-Amyron) 对基孔肯雅病毒复制具有抗真菌活性，EC50 为 86 uM。 beta-Amyrone 通过抑制 COX-2 的表达而具有抗炎活性。 beta-Amyrone 表现出抗α-葡萄糖苷酶抑制活性和中等 AChE 活性。 β-Amyrone 可用于炎症、感染和肥胖等疾病的研究。
T4S1173	Agrimol B 仙鹤草酚B,仙鹤草酚 B	Sirtuin; PPAR	Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism
	Agrimol B 是从仙鹤草中分离得到的一种多酚衍生物，可抑制脂肪形成，降低PPARγ的表达，诱导SIRT1易位和表达。
TN2121	3,5,7,3′,4′-Pentamethoxyflavone 栎精-3,5,7,3',4'-五甲醚,槲皮素3,5,7,3',4'-五甲基醚,Quercetin 3,5,7,3,4-pentamethyl ether	Others	Others
	3,5,7,3′,4′-Pentamethoxyflavone (Quercetin 3,5,7,3,4-pentamethyl ether) 是一种分离自小花山奈中的多甲氧基黄酮。在分化早期，它可以调控转录因子，促进 3T3-L1 前脂肪细胞形成脂肪。
T21344	1-Deoxynojirimycin hydrochloride Moranoline,去氧野艽霉素盐酸盐,AT2220,Duvoglustat hydrochloride,1-Deoxynojirimycin,DNJ,deoxynojirimycin	PI3K; Antibacterial; Antibiotic; Glucosidase	Metabolism; Microbiology/Virology; PI3K/Akt/mTOR signaling
	1-Deoxynojirimycin hydrochloride (Moranoline) 是一种口服有效的 α-葡萄糖苷酶抑制剂，具有降血糖、减肥和抗病毒的作用，可抑制餐后血糖，预防糖尿病。
T8292	(-)-Cedrene α-柏木烯,Alpha-Cedrene	Others; Antibacterial	Microbiology/Virology; Others
	(-)-Cedrene (Alpha-Cedrene) 是一种来自雪松油中的倍半萜烯，有抗白血病、抗菌和抗肥胖作用。
TN1803	Isoscoparin	Antioxidant; TNF; NO Synthase; Fatty Acid Synthase	Apoptosis; Immunology/Inflammation; Metabolism; oxidation-reduction
	Isoscoparin 源自 Gentiana algida Pall，具有抗氧化和抗脂肪生成活性。Isoscoparin 可用于预防和治疗肥胖的研究。
T7600	Fucoxanthin all-trans-Fucoxanthin	Others	Others
	Fucoxanthin (all-trans-Fucoxanthin) 是海洋类胡萝卜素，具有抗肥胖，抗糖尿病，抗炎，抗氧化，抗癌等作用。
T2868	Evodiamine d-Evodiamine,Isoevodiamine,(+)-Evodiamine,吴茱萸碱	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	Evodiamine (d-Evodiamine) 是一种生物碱，从萱草的果实中分离得到，具有多种生物活性，包括抗炎，抗肥胖和抗肿瘤。
TN1189	13-Methylberberine chloride 13-甲基小檗碱,13-Methylberberine	Others	Others
	13-Methylberberine chloride 是一种黄连素类似物，可增加 IL-12 的产生，并在 LPS 激活的巨噬细胞转录后抑制 iNOS 的表达，具有抗脂肪和抗肿瘤作用。
T10584	Bovinic acid (9Z,11E)-Octadecadienoic acid,Rumenic acid	Endogenous Metabolite	Metabolism
	Bovinic acid ((9Z,11E)-Octadecadienoic acid) 是一种具有抗癌和抗动脉硬化的活性的共轭亚油酸，可用于研究老年冠心病和肥胖。
TN1824	Kaempferol 3-sophoroside-7-glucoside	Antioxidant	oxidation-reduction
	Kaempferol 3-sophoroside-7-glucoside 是一种龙脷叶中的生物活性成分，属于黄酮类，具有抗氧化和抗肥胖活性。
T5240	Cholestenone 胆甾烯酮,4-胆甾烯-3-酮,(+)-4-Cholesten-3-one	Others; Endogenous Metabolite	Metabolism; Others
	Cholestenone ((+)-4-Cholesten-3-one) 是胆固醇的中间氧化产物，主要在肝脏中代谢。它能够会导致细胞长期功能缺陷。它在膜中具有很高的流动性，会影响胆固醇的翻转和外排。
T2P2919	(2S,3R,4S)-4-Hydroxyisoleucine (4S)-4-Hydroxy-L-isoleucine,(4S)4-羟基异亮氨酸,Hydroxyisoleucine	PI3K	PI3K/Akt/mTOR signaling
	(2S,3R,4S)-4-Hydroxyisoleucine (Hydroxyisoleucine) 是分离自胡芦巴中的一种可口服的有效成分，具有抗糖尿病、抗糖尿病肾病的作用。
T2854	Phillyrin Forsythin,连翘苷	P450; Influenza Virus; AMPK	Chromatin/Epigenetic; Metabolism; Microbiology/Virology; PI3K/Akt/mTOR signaling
	Phillyrin (Forsythin) 是从连翘中分离出来的一种天然产物，具有抗甲型流感病毒的活性，以及抗菌和消炎作用。
T3S0195	Nootkatone 诺卡酮,努特卡酮,诺卡酮	AMPK	Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
	Nootkatone 是一种神经保护剂，来自于Alpiniae OxyphyllaeFructus ，具有抗氧化和抗炎活性。它能够改善脂多糖诱导的阿尔茨海默氏病小鼠模型的认知障碍。
TN2019	Orobol 3'-Hydroxygenistein,3’,4’,5,7-tetrahydroxy-isoflavon,3',4',5,7-四羟基异黄酮	BCL; Caspase; PI3K	Apoptosis; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Orobol (3’,4’,5,7-tetrahydroxy-isoflavon) 是酪氨酸特异性蛋白激酶和磷脂酰肌醇转换的抑制剂。Orobol 抑制 PI3K，对 PI3K α/β/γ/K/δ 的 IC50 为 3.46-5.27 μM。 Orobol 具有抗皮肤老化和抗肥胖的作用。
TCS1772	Dehydroabietic acid Dehydroabietate,脱氢松香酸	Antifection	Microbiology/Virology
	Dehydroabietic acid (Dehydroabietate) 是 EBV-EA 活化抑制剂。它是食物衍生化合物，可通过降低血浆葡萄糖、胰岛素水平、血浆甘油三酯 (TG) 和肝 TG 水平来治疗肥胖相关疾病。它的衍生物在动物模型中表现出抗分泌和抗胃蛋白酶作用。
T3921	Punicalagin 安石榴甙,安石榴苷	SARS-CoV; HBV	Microbiology/Virology
	Punicalagin 是一种在石榴中发现的主要鞣花单宁，是可逆且非竞争性的3CLpro 抑制剂，有抗氧化、抗炎和抗癌作用。它有潜力研究 COVID-19 。
T7984	2-Hydroxyflavanone	Others	Others
	2-Hydroxyflavanone 是一种天然存在的黄酮类化合物，存在于许多植物和水果中。它具有抗氧化、抗炎和抗肿瘤的活性，可以清除自由基，减少炎症，并抑制肿瘤细胞的生长，还具有治疗糖尿病、肥胖症、心血管疾病和神经系统疾病等多种疾病的潜力。
T8072	S-Methyl-L-cysteine S-甲基-L-半胱氨酸,S-Methylcysteine	Antioxidant; Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB; oxidation-reduction
	S-Methyl-L-cysteine (S-Methylcysteine) 是一种催化抗氧化系统中甲硫氨酸硫氧化物还原酶 A 的作用底物，是一种天然产物，具有抗氧化、神经保护及减肥的功效。
T12045	(-)-Hydroxycitric acid lactone 藤黄内酯,Garcinia lactone	ATP Citrate Lyase	Metabolism
	(-)-Hydroxycitric acid lactone (Garcinia lactone) 是一种有效的 ATP-柠檬酸裂解酶抑制剂，能够催化柠檬酸盐线粒体外裂解为草酰乙酸和乙酰辅酶 A，限制了脂肪酸合成所需乙酰辅酶 A 单位的可用性。它是一种减肥药，是一种广受欢迎的减肥食品补充剂。
T4S0878	Prunetin 樱黄素,Prunusetin	ERK; Dehydrogenase; NF-κB	MAPK; Metabolism; NF-κB
	Prunetin (Prunusetin) 是一种O-甲基化异黄酮，具有抗炎的作用。它是人醛脱氢酶的有效抑制剂。
T3S1513	(20R)-Protopanaxadiol Protopanaxadiol,20R-Protopanaxadiol,(20R)-原人参二醇,(20R)-Protopanaxdiol	Others; Antibacterial	Microbiology/Virology; Others
	(20R)-Protopanaxadiol ((20R)-Protopanaxdiol) 是黑参中20(R)-人参皂甙 Rg3的一种三萜皂苷代谢物。它抑制幽门螺杆菌的生长，有抗肿瘤活性和细胞毒性。
T4723	D-Tagatose 塔格糖,D-(-)-Tagatose,D-塔格糖,d-tagatos	Others; Endogenous Metabolite	Metabolism; Others
	D-Tagatose (D-(-)-Tagatose) 是自然界中发现的一种罕见的单糖，具有益生元特性。它是研究II 型糖尿病的潜在抗糖尿病药物，也是帮助提升结肠有益细菌、预防结肠癌和抑制胆固醇的益生元。它是蔗糖的替代品，也是口香糖、果汁和饮料等食品中的低热量甜味剂。
T5S1172	Tiliroside 银椴甙,Tribuloside,银椴苷；椴树苷	Antioxidant	oxidation-reduction
	Tiliroside (Tribuloside) 是糖苷类黄酮，是 α-淀粉酶的非竞争性抑制剂(Ki:84.2 μM)。它抑制胃肠道中碳水化合物的消化和葡萄糖的吸收，具有抗糖尿病作用。
TN1206	2,4,6-Trihydroxybenzaldehyde	Others	Others
	2,4,6-Trihydroxybenzaldehyde 是一种天然产物。 2,4,6-三羟基苯甲醛是一种潜在的抗肥胖治疗药物，可抑制 C57BL/6 小鼠的 3T3-L1 细胞中的脂肪细胞分化和高脂饮食诱导的脂肪积累。它也是一种有效的抗糖尿病药物。 2,4,6-三羟基苯甲醛具有潜在的抗癌活性。
TN4879	Questinol	IL Receptor; TNF; COX; Prostaglandin Receptor	Apoptosis; GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Questinol exhibits significant anti-obesity activity. It shows anti-inflammatory effect in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells, it can inhibit the production of pro-inflammatory cytokines, including TNF-α, IL-1β, and IL-6 and inhibit NO an
T74133	23-epi-26-Deoxyactein
	23-epi-26-Deoxyactein 是天然的、具有口服活性的抗肥胖和抗肿瘤作用的化合物。
TN6613	Delphinidin-3-O-galactoside chloride
	Delphinidin-3-O-galactoside chloride has anti-obesity and hypolipidemic effects. Delphinidin-3-O-galactoside (D3G) is a water-soluble anthocyanin with antioxidant activity. D3G is capable of masking the EGCG-induced cytotoxicity and ER stress, presumably
TMA0291	Dehydroglyasperin D	GSK-3; p38 MAPK; ROS; Akt; COX; PI3K; DNA/RNA Synthesis; Prostaglandin Receptor; JNK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; DNA Damage/DNA Repair; GPCR/G Protein; Immunology/Inflammation; MAPK; Neuroscience; PI3K/Akt/mTOR signaling; Stem Cells
	Dehydroglyasperin D exhibits anticancer, anti-inflammatory, anti-obesity, antioxidant and anti-aldose reductase effects, it inhibits the proliferation of HT-29 human colorectal cancer cells through direct interaction with phosphatidylinositol 3-kinase; it also mediates suppression of both COX-2 expression and the MLK3 signalling pathway through direct binding and inhibition of MLK3. Dehydroglyasperin D shows strong ferric reducing activities and effectively scavenged DPPH, ABTS(+), and singlet o...
TN4094	Gallocatechin gallate	IL Receptor; NF-κB; ROS; MAPK; PPAR; Fatty Acid Synthase	DNA Damage/DNA Repair; Immunology/Inflammation; MAPK; Metabolism; NF-κB
	Gallocatechin gallate has strong antioxidative, and anti-obesity activities, it inhibits 3T3-L1 differentiation and lipopolysaccharide induced inflammation through MAPK and NF-ÎºB signaling; it also may have anti-diabetic effects by increasing sensitivity
TN4092	Galanolactone	5-HT Receptor	GPCR/G Protein; Neuroscience
	Galanolactone has anti-5-HT effect, a diterpenoid isolated from ginger, is related to antagonism of 5-HT3 receptors, it has inhibit nitric oxide production with IC(50) values ranging from 5.5 to 28.5 μM. Galanolactone exerts anti-obesity effect through do
TN4213	Hirsutenone	ERK; EGFR; IL Receptor; NF-κB; Akt; PI3K; Antifection; mTOR; p53; Autophagy	Angiogenesis; Apoptosis; Autophagy; Cytoskeletal Signaling; Immunology/Inflammation; JAK/STAT signaling; MAPK; Microbiology/Virology; NF-κB; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	Hirsutenone has potent antioxidant activity, it shows significant free radical scavenging activity and exhibits inhibition effect on the mitochondrial lipid peroxidation.Hirsutenone exhibits anti-cancer, and anti-filarial effects, it may exert a preventive effect against microbial endotoxin lipopolysaccharide-induced inflammatory skin diseases through inhibition of ERK pathway-mediated NF-kappaB activation. Hirsutenone attenuates adipogenesis by directly targeting PI3K and ERK during MCE in 3T3-...
TN3070	4beta-Hydroxywithanolide E	PARP; HSP; NF-κB; COX	Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Neuroscience; NF-κB
	4beta-Hydroxywithanolide E(4bHWE) can inhibit the growth of colon cancer monolayer and spheroid cultures, it assert its anti-tumor activity in carcinogenic progression and develop into a dietary chemopreventive agent, it affects alternative splicing by mo
TN3779	De-O-methyllasiodiplodin	IL Receptor; TNF; ROS; Antifection	Apoptosis; Immunology/Inflammation; Microbiology/Virology
	De-O-methyllasiodiplodin exhibits radical scavenging, moderate antibacterial, and potential anti-inflammatory effects, it shows moderate suppression effects on induced NO production. De-O-methyllasiodiplodin effectively lowers the blood glucose level in d

天然产物

Cat.No: T3672

Target: MAPK

Cat.No: T5751

Target: Others

5,7-DIMETHOXYFLAVONE

Cat.No: T5778

Target: Anti-infection, P450

Cat.No: T5583

Synonym: 松二糖,D-(+)-Turanose

Target: Endogenous Metabolite

1-Deoxynojirimycin

Cat.No: T3675

Synonym: Duvoglustat,Moranoline,1-脱氧野尻霉素,moranolin

Target: PI3K, Glucosidase

Cat.No: TN3500

Synonym: β-Amyron,β-香树脂酮

Target: COX, AChR, PPAR, Antifection

Cat.No: T4S1173

Synonym: 仙鹤草酚B,仙鹤草酚 B

Target: Sirtuin, PPAR

3,5,7,3′,4′-Pentamethoxyflavone

Cat.No: TN2121

Synonym: 栎精-3,5,7,3',4'-五甲醚,槲皮素3,5,7,3',4'-五甲基醚,Quercetin 3,5,7,3,4-pentamethyl ether

Target: Others

1-Deoxynojirimycin hydrochloride

Cat.No: T21344

Synonym: Moranoline,去氧野艽霉素盐酸盐,AT2220,Duvoglustat hydrochloride,1-Deoxynojirimycin,DNJ,deoxynojirimycin

Target: PI3K, Antibacterial, Antibiotic, Glucosidase

Cat.No: T8292

Synonym: α-柏木烯,Alpha-Cedrene

Target: Others, Antibacterial

Cat.No: TN1803

Target: Antioxidant, TNF, NO Synthase, Fatty Acid Synthase

Cat.No: T7600

Synonym: all-trans-Fucoxanthin

Target: Others

Cat.No: T2868

Synonym: d-Evodiamine,Isoevodiamine,(+)-Evodiamine,吴茱萸碱

Target: Prostaglandin Receptor

13-Methylberberine chloride

Cat.No: TN1189

Synonym: 13-甲基小檗碱,13-Methylberberine

Target: Others

Cat.No: T10584

Synonym: (9Z,11E)-Octadecadienoic acid,Rumenic acid

Target: Endogenous Metabolite

Kaempferol 3-sophoroside-7-glucoside

Cat.No: TN1824

Target: Antioxidant

Cat.No: T5240

Synonym: 胆甾烯酮,4-胆甾烯-3-酮,(+)-4-Cholesten-3-one

Target: Others, Endogenous Metabolite

(2S,3R,4S)-4-Hydroxyisoleucine

Cat.No: T2P2919

Synonym: (4S)-4-Hydroxy-L-isoleucine,(4S)4-羟基异亮氨酸,Hydroxyisoleucine

Target: PI3K

Cat.No: T2854

Synonym: Forsythin,连翘苷

Target: P450, Influenza Virus, AMPK

Cat.No: T3S0195

Synonym: 诺卡酮,努特卡酮,诺卡酮

Target: AMPK

Cat.No: TN2019

Synonym: 3'-Hydroxygenistein,3’,4’,5,7-tetrahydroxy-isoflavon,3',4',5,7-四羟基异黄酮

Target: BCL, Caspase, PI3K

Dehydroabietic acid

Cat.No: TCS1772

Synonym: Dehydroabietate,脱氢松香酸

Target: Antifection

Cat.No: T3921

Synonym: 安石榴甙,安石榴苷

Target: SARS-CoV, HBV

2-Hydroxyflavanone

Cat.No: T7984

Target: Others

S-Methyl-L-cysteine

Cat.No: T8072

Synonym: S-甲基-L-半胱氨酸,S-Methylcysteine

Target: Antioxidant, Reactive Oxygen Species

(-)-Hydroxycitric acid lactone

Cat.No: T12045

Synonym: 藤黄内酯,Garcinia lactone

Target: ATP Citrate Lyase

Cat.No: T4S0878

Synonym: 樱黄素,Prunusetin

Target: ERK, Dehydrogenase, NF-κB

(20R)-Protopanaxadiol

Cat.No: T3S1513

Synonym: Protopanaxadiol,20R-Protopanaxadiol,(20R)-原人参二醇,(20R)-Protopanaxdiol

Target: Others, Antibacterial

Cat.No: T4723

Synonym: 塔格糖,D-(-)-Tagatose,D-塔格糖,d-tagatos

Target: Others, Endogenous Metabolite

Cat.No: T5S1172

Synonym: 银椴甙,Tribuloside,银椴苷；椴树苷

Target: Antioxidant

2,4,6-Trihydroxybenzaldehyde

Cat.No: TN1206

Target: Others

Cat.No: TN4879

Target: IL Receptor, TNF, COX, Prostaglandin Receptor

23-epi-26-Deoxyactein

Cat.No: T74133

Delphinidin-3-O-galactoside chloride

Cat.No: TN6613

Dehydroglyasperin D

Cat.No: TMA0291

Target: GSK-3, p38 MAPK, ROS, Akt, COX, PI3K, DNA/RNA Synthesis, Prostaglandin Receptor, JNK

Gallocatechin gallate

Cat.No: TN4094

Target: IL Receptor, NF-κB, ROS, MAPK, PPAR, Fatty Acid Synthase

Cat.No: TN4092

Target: 5-HT Receptor

Cat.No: TN4213

Target: ERK, EGFR, IL Receptor, NF-κB, Akt, PI3K, Antifection, mTOR, p53, Autophagy

4beta-Hydroxywithanolide E

Cat.No: TN3070

Target: PARP, HSP, NF-κB, COX

De-O-methyllasiodiplodin

Cat.No: TN3779

Target: IL Receptor, TNF, ROS, Antifection

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