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Search Results for " osteoclast "

41

抑制剂 & 化合物

23

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T16159	Muramyl dipeptide MDP	NOD	Immunology/Inflammation; NF-κB
	Muramyl dipeptide (MDP) 是合成的免疫反应肽，由 N-乙酰壁酸与 L-Ala-D-isoGln 的短氨基酸链相连。它通过MAPK 途径上调 Runx2 基因表达，直接促进成骨细胞分化，通过降低 RANKL/OPG 比值间接抑制破骨细胞分化。它是通过Runx2诱导骨形成的诱导因子，也是NLRP1激动剂。
T13324	VUF11207 fumarate	CXCR; Arrestin	Autophagy; GPCR/G Protein; Immunology/Inflammation
	VUF11207 fumarate 是一种 CXCR7激动剂和高效CXCR7配体，pKi 为 8.1。它可诱导CXCR7的β-arrestin2募集和随后的内在化，pEC50分别为 8.8 和 7.9。
T6739	Zoledronic Acid CGP-4244,CGP42446A,唑来膦酸,Zoledronate,CGP 42446,ZOL 446,Zometa	Apoptosis; Rho; Autophagy	Apoptosis; Autophagy; Cell Cycle/Checkpoint
	Zoledronic Acid (ZOL 446) 是一种含氮二磷酸盐，能抑制破骨细胞的分化和凋亡，具有高效的抗骨质再吸收活性，也有抗癌作用。
T21299	Zoledronic acid monohydrate 唑来膦酸一水合物,zoledronate,ZOL 446,CGP 42446,CGP42446A,Zoledronic acid hydrate	Apoptosis; Others; Autophagy	Apoptosis; Autophagy; Others
	Zoledronic acid monohydrate (CGP 42446) 是一种含氮二磷酸盐，具有高效的抗骨质再吸收活性。它能抑制破骨细胞的分化和凋亡，有抗癌作用。
T1925	PLX647	c-Fms; c-Kit	Tyrosine Kinase/Adaptors
	PLX647 是具有口服活性的、高效的、特异性的FMS 和KIT 双激酶抑制剂，IC50分别为 28 和 16 nM。它 (1 μM) 在 400 个激酶组中显示出对 FMS 和 KIT 有选择性，但 FLT3 和 KDR 除外 (IC50=91 和 130 nM)。
T61531	NFATc1-IN-1	RANKL/RANK	NF-κB
	NFATc1-IN-1 (also known as compound A04) is a highly effective inhibitor of osteoclast formation induced by RANKL, with an IC50 of 1.57 μM. It exerts its anti-osteoclastogenic effects by attenuating the RANKL-induced nuclear translocation of NFATc1. Due to its remarkable properties, NFATc1-IN-1 holds significant potential for advancing research related to osteoclastic diseases [1].
T0379	Risedronic Acid Risedronate,利塞膦酸	Others; Transferase	Metabolism; Others
	Risedronic Acid (Risedronate) 具有抑制破骨细胞介导的骨重吸收的作用。
T9823	WAY-325398	Others	Others
	WAY-325398是一种呋喃衍生物。WAY-325398抑制破骨细胞形成，10μM 时抑制率为14.11%。
T13159	Tiludronate disodium Tiludronic Acid disodium,Tiludronic acid disodium	ATPase	Membrane transporter/Ion channel
	Tiludronate disodium (Tiludronic acid disodium) 是一种破骨细胞液泡 H(+)-ATPase 抑制剂，具有抗骨吸收和抗炎特性。 Tiludronate disodium 可用于有关代谢性骨病的研究。
T9917	Denosumab	RANKL/RANK	NF-κB
	Denosumab 是能够结合并抑制RANKL 受体激活因子的人单克隆抗体。它具有抗癌活性，可降髋部、低椎骨以及非椎骨骨折的风险。
T77567	BCPA	Others	Others
	BCPA 是一种无细胞毒性的 Pin1 调节剂。BCPA 可调节破骨细胞活化，减弱 Pin1 蛋白的减少，从而抑制 RANKL 诱导的破骨细胞发生的受体激活物。BCPA 用于研究骨质疏松。
T27371	FR-167356 FR167356,FR 167356	ATPase	Membrane transporter/Ion channel
	FR-167356 是 a3 异构体液泡型 H+-ATPase 的特异性抑制剂，对破骨细胞质膜、肾刷状缘膜和巨噬细胞微粒体的 IC50 分别为 170 nM、370 nM 和 220 nM。 FR-167356 减少 B16-F10 细胞的骨转移。
T2188	Thonzonium Bromide 嘧苯十六铵,通佐溴胺	Proton pump; Antibacterial; Autophagy	Autophagy; Membrane transporter/Ion channel; Microbiology/Virology
	Thonzonium bromide 是一种单阳离子表面活性剂，在结构上与 Farnesol 相似的抗菌剂。它以剂量依赖的方式抑制质子转运 (EC50=69 μM)。在体外可抑制 RANKL 诱导的破骨细胞形成和骨吸收，并在体内阻止 LPS 诱导的骨丢失。
T26514	ABD56 ABD-56,ABD 56
	ABD56 inhibits osteoclast formation and activity in vitro and in vivo.
T69656	E197
	E197 is a DOCK5 inhibitor. E197 can inhibit both mouse and human osteoclast activity. In particular, E197 prevented pathological bone loss in mice. Most interestingly, treatment with E197 did not affect osteoclast and osteoblast numbers and hence did not impair bone formation. E197 could represent a lead molecule to develop new antiosteoporotic drugs targeting the mechanism of osteoclast adhesion onto the bone.
T29109	VPC12249 VPC-12249,VPC 12249
	VPC12249, a lysophosphatidic acid receptor type 1 (LPA1) antagonist, plays a functional role in osteoclast differentiation and bone resorption activity.
T30089	AP-22161 AP22161,G7VE62573J,UNII-G7VE62573J,SCHEMBL7243003,AP 22161
	AP-22161 selectively binds the Src SH2 domain by targeting highly conserved phosphotyrosine binding to cysteine residues in the pocket. AP-22161 selectively inhibits Src SH2 binding and can be used to inhibit osteoclast absorption.
T40328	Betulinic acid derivative-1
	Betulinic acid derivative-1 demonstrates potent inhibition of osteoclast (OC) differentiation, achieving an IC50 value of 1.86 μM.
T26512	ABD-295
	ABD-295 is an antiresorptive agent, osteoclast inhibitor, and biphenylsulfide derivative. ABD-295 has potent inhibitory effects on osteoclastic bone resorption in vitro. ABD-295 prevents ovariectomy-induced bone loss in vivo.
T61764	Zoledronic acid disodium tetrahydrate
	Zoledronic Acid (Zoledronate) disodium tetrahydrate is a potent third-generation bisphosphonate (BP), exhibiting strong anti-resorptive activity. It effectively inhibits osteoclast differentiation and apoptosis, while also demonstrating anti-cancer properties [1].
T72008	E09241
	E09241 is a novel OPG/RANKL upregulator, increasing OPG expression without affecting RANKL expression, promoting osteoblast differentiation while inhibiting osteoclast differentiation, regulating OPG expression through canonical Wnt/β-catenin signaling.
T83032	Anti-osteoporosis agent-7
	Anti-osteoporosis agent-7 (Compound 133) 作为一种潜在的抗骨质疏松剂，对破骨细胞的形成展示了高度的抑制效果。
T82359	G-{d-Arg}-GDSP
	G-{d-Arg}-GDSP为RGD多肽类似物，具有与整合素粘附受体结合的能力，能够抑制细胞对纤维连接蛋白的附着及破骨细胞的重吸收。
T39037	Tiludronate disodium hemihydrate Tiludronic acid disodium hemihydrate,替鲁膦酸二钠半水合物
	Tiludronate (Tiludronic Acid) disodium hemihydrate is an orally active bisphosphonate compound that functions as an osteoregulator. It is primarily utilized in metabolic bone disorder research. This compound acts as a potent inhibitor of the osteoclast vacuolar H+ -ATPase and possesses antiresorptive and anti-inflammatory properties[4].
T71479	Kahweol oleate
	Kahweol oleate is emi-syntetic derivative of kahweol, a natural product found in coffee beans. It exhibits a wide variety of biological activities, including inhibiting RANKL-induced osteoclast generation, inducing cell cycle arrest and apoptosis in oral squamous cell carcinoma cells, preventing aflatoxin B1 induced DNA adduct formation, and suppressing H2O2-induced DNA damage and oxidative stress.
T73056	Tiludronate Tiludronic acid
	Tiludronate (Tiludronic Acid) 是一种口服活性双膦酸盐，可以起到骨调节作用。Tiludronate 用于代谢性骨疾病的研究。Tiludronate 是破骨细胞空泡 H(+)-ATP 酶的有效抑制剂。
T79472	CSF1R-IN-17	c-Fms	Tyrosine Kinase/Adaptors
	CSF1R-IN-17（compound 9）是一种选择性高的CSF1R拮抗剂，表现出0.2 nM的低IC50值，并能有效抑制破骨细胞的分化。
T68642	Kahweol palmitate
	Kahweol palmitate is a semi-synthetic derivative of kahweol, a natural product found in coffee beans. It exhibits a wide variety of biological activities, including inhibiting RANKL-induced osteoclast generation, inducing cell cycle arrest and apoptosis in oral squamous cell carcinoma cells, preventing aflatoxin B1-induced DNA adduct formation, and suppressing H2O2-induced DNA damage and oxidative stress.
T71480	Kahweol linoleate
	Kahweol linoleate is a semi-syntetic derivative of kahweol, a natural product found in coffee beans. It exhibits a wide variety of biological activities, including inhibiting RANKL-induced osteoclast generation, inducing cell cycle arrest and apoptosis in oral squamous cell carcinoma cells, preventing aflatoxin B1 induced DNA adduct formation, and suppressing H2O2-induced DNA damage and oxidative stress.
T71478	Kahweol stearate
	Kahweol stearate is a semi-synthetic derivative of kahweol, a natural product found in coffee beans. It exhibits a wide variety of biological activities, including inhibiting RANKL-induced osteoclast generation, inducing cell cycle arrest and apoptosis in oral squamous cell carcinoma cells, preventing aflatoxin B1-induced DNA adduct formation, and suppressing H2O2-induced DNA damage and oxidative stress.
T68641	Kahweol Acetate
	Kahweol Acetate is a semi-synthetic derivative of kahweol, a natural product found in coffee beans. It exhibits a wide variety of biological activities, including inhibiting RANKL-induced osteoclast generation, inducing cell cycle arrest and apoptosis in oral squamous cell carcinoma cells, preventing aflatoxin B1 induced DNA adduct formation, and suppressing H2O2-induced DNA damage and oxidative stress.
T78208	Leramistat HMC-C-01-A,MBS2320	Mitochondrial Metabolism	Metabolism
	Leramistat (HMC-C-01-A; MBS2320)为线粒体复合物1抑制剂，关与调控细胞代谢及免疫代谢。该化合物被用于抑制诸如特应性皮炎的皮肤病、自身免疫性与炎症性疾病和癌症，以及破骨细胞介导的疾病。
T37409	DPC-AJ1951 (trifluoroacetate salt) DPC-AJ1951 (trifluoroacetate salt)
	DPC-AJ1951 is a peptide agonist of the parathyroid hormone (PTH)/PTH-related peptide receptor (PPR; EC50 = 0.15 nM in HEK293 cells expressing human PPR). It induces cAMP production in SAOS-2 and UMR106 cells that endogenously express human and rat PPR, respectively (EC50s = 2.2 and 1.1 nM, respectively). DPC-AJ1915 stimulates osteoclast-mediated bone resorption in fetal rat long-bone explant cultures and increases collagen synthesis and cell proliferation in neonatal mouse parietal bone explants...
T78037	Hepcidin-1 (mouse) TFA
	Hepcidin-1 (mouse) TFA是调控铁代谢平衡的肽类激素。该化合物通过提高TRAP、组织蛋白酶K及MMP-9的mRNA水平并促进TRAP-5b蛋白的分泌，同时降低FPN1蛋白表达，导致细胞内铁含量上升。此外，Hepcidin-1 (mouse) TFA还有助于破骨细胞的分化。
T81171	SH491
	SH491（Compound 33）是一款抗骨质疏松药物。该化合物能够抑制RANKL诱导的骨髓源性单核细胞（BMM）分化为破骨细胞（IC50: 11.8 nM）。同时，SH491降低了破骨细胞形成的相关标记基因（TRAP、CTSK、MMP-9和ATPase v0d2）以及相应蛋白（TRAP、CTSK、MMP-9）的表达。
T80108	Hepcidin-1 (mouse)
	Hepcidin-1 (mouse) 是调控铁平衡的内源性多肽激素，通过上调TRAP、组织蛋白酶K和MMP-9的mRNA水平及增强TRAP-5b蛋白的分泌作用。此外，Hepcidin-1 (mouse) 降低FPN1蛋白水平并提升细胞内铁含量，且促进破骨细胞的分化。
T73885	Methyl gerfelin
	Methyl gerfelin通过与三种关键细胞蛋白乙二醛酶 1 (GLO1)、固醇结合蛋白 2 (SCP2) 和富含谷氨酰胺的四肽重复蛋白 A (SGTA) 结合，抑制破骨细胞的分化。研究表明，Methyl gerfelin是一种与类黄酮相关的强效GLO1抑制剂。
T40463	Relacatib SB-462795
	Relacatib (SB-462795) is a novel, potent, and orally active inhibitor of human cathepsins K, L, and V. It exhibits high affinity for these enzymes, with Ki values of 41 pM, 68 pM, and 53 pM, respectively. Moreover, Relacatib effectively inhibits endogenous cathepsin K in situ in human osteoclasts, as well as human osteoclast-mediated bone resorption, with IC 50 values of 45 nM and 70 nM, respectively. Additionally, in vitro studies demonstrate Relacatib's inhibitory effect on bone resorption in ...
T76786	Cabiralizumab
	Cabiralizumab (FPA 008) 是一种抗 CSF1R 单克隆抗体 (MAb)。Cabiralizumab 可增强 T 细胞浸润和抗肿瘤 T 细胞免疫反应。Cabiralizumab 抑制破骨细胞的活化并阻止骨质破坏，可用于类风湿性关节炎 (RA) 的研究。Cabiralizumab 可与 Nivolumab 结合用于肺癌研究。
T78816	Anti-osteoporosis agent-4	NF-κB	NF-κB
	Anti-osteoporosis agent-4 (Compound 11h) 在生物医学领域中表现为有效抑制原代破骨细胞的分化，减弱RANKL诱导的破骨细胞生成，并展示出强抑制作用，具有 IC50 值为358.29 nM。此外，该化合物还能抑制关键的 PI3K/AKT 和 IκBα/NF-κB 信号通路激活，表明其在防治骨质疏松症中的潜在应用价值。
T83848	VnP-16 TFA
	VnP-16是一种合成肽段，对应vitronectin的氨基酸270-281，vitronectin是一种具有细胞附着、迁移和扩散等多功能作用的糖蛋白。该肽段在9.1 µg/cm2浓度下应用于细胞板时，能促进人类成骨细胞的附着和扩散，此效应可通过β1整合素的siRNA敲除被逆转。VnP-16诱导人类皮肤来源的间充质前体细胞和MC3T3-E1小鼠颅骨成骨前体细胞的成骨作用。在体内，VnP-16减少IL-1α诱导的骨质流失并减少小鼠颅骨中破骨细胞的数量。它还在卵巢切除引起的骨质疏失小鼠模型中增加骨矿物质密度并减少松质骨流失。

化合物

Muramyl dipeptide

Cat.No: T16159

Synonym: MDP

Target: NOD

VUF11207 fumarate

Cat.No: T13324

Target: CXCR, Arrestin

Zoledronic Acid

Cat.No: T6739

Synonym: CGP-4244,CGP42446A,唑来膦酸,Zoledronate,CGP 42446,ZOL 446,Zometa

Target: Apoptosis, Rho, Autophagy

Zoledronic acid monohydrate

Cat.No: T21299

Synonym: 唑来膦酸一水合物,zoledronate,ZOL 446,CGP 42446,CGP42446A,Zoledronic acid hydrate

Target: Apoptosis, Others, Autophagy

Cat.No: T1925

Target: c-Fms, c-Kit

Cat.No: T61531

Target: RANKL/RANK

Risedronic Acid

Cat.No: T0379

Synonym: Risedronate,利塞膦酸

Target: Others, Transferase

Cat.No: T9823

Target: Others

Tiludronate disodium

Cat.No: T13159

Synonym: Tiludronic Acid disodium,Tiludronic acid disodium

Target: ATPase

Cat.No: T9917

Target: RANKL/RANK

Cat.No: T77567

Target: Others

Cat.No: T27371

Synonym: FR167356,FR 167356

Target: ATPase

Thonzonium Bromide

Cat.No: T2188

Synonym: 嘧苯十六铵,通佐溴胺

Target: Proton pump, Antibacterial, Autophagy

Cat.No: T26514

Synonym: ABD-56,ABD 56

Cat.No: T69656

Cat.No: T29109

Synonym: VPC-12249,VPC 12249

Cat.No: T30089

Synonym: AP22161,G7VE62573J,UNII-G7VE62573J,SCHEMBL7243003,AP 22161

Betulinic acid derivative-1

Cat.No: T40328

Cat.No: T26512

Zoledronic acid disodium tetrahydrate

Cat.No: T61764

Cat.No: T72008

Anti-osteoporosis agent-7

Cat.No: T83032

Cat.No: T82359

Tiludronate disodium hemihydrate

Cat.No: T39037

Synonym: Tiludronic acid disodium hemihydrate,替鲁膦酸二钠半水合物

Cat.No: T71479

Cat.No: T73056

Synonym: Tiludronic acid

Cat.No: T79472

Target: c-Fms

Kahweol palmitate

Cat.No: T68642

Kahweol linoleate

Cat.No: T71480

Kahweol stearate

Cat.No: T71478

Kahweol Acetate

Cat.No: T68641

Cat.No: T78208

Synonym: HMC-C-01-A,MBS2320

Target: Mitochondrial Metabolism

DPC-AJ1951 (trifluoroacetate salt)

Cat.No: T37409

Synonym: DPC-AJ1951 (trifluoroacetate salt)

Hepcidin-1 (mouse) TFA

Cat.No: T78037

Cat.No: T81171

Hepcidin-1 (mouse)

Cat.No: T80108

Methyl gerfelin

Cat.No: T73885

Cat.No: T40463

Synonym: SB-462795

Cat.No: T76786

Anti-osteoporosis agent-4

Cat.No: T78816

Target: NF-κB

Cat.No: T83848

Cat. No.	Product Name	Target	Signaling Pathways
T3816	Velutin	NF-κB; HIF/HIF Prolyl-Hydroxylase	Chromatin/Epigenetic; Metabolism; NF-κB
	Velutin 是一种苷元，提取自槲寄生中，能够抑制黑色素生物合成。它利用 NF-κB 途径减少破骨细胞分化和下调 HIF-1α。
TN5888	Toddaculin	Others	Others
	Toddaculin 是一种天然香豆素，抑制过度的破骨细胞活性并增强成骨细胞分化和矿化。它可诱导白血病细胞分化和凋亡，具有抗炎活性。
TN1040	Skullcapflavone II	COX; Antibacterial; TGF-beta/Smad	Immunology/Inflammation; Microbiology/Virology; Neuroscience; Stem Cells
	Skullcapflavone II 是从黄芩中提取的黄酮，具有抗炎作用。它对 M. aurum 和 M. bovisBCG 具有较强的抗菌活性。它还调节破骨细胞的分化、存活和功能。
TN2347	Methylsticin 麻醉椒苦素,Methysticin	Others	Others
	Methylsticin (Methysticin) 是一种卡瓦内酯，从卡瓦根中分离得到。它能够抑制破骨细胞形成的活性。
T2731	Usnic Acid Usniacin,松萝酸,地衣酸	Antibacterial; Autophagy	Autophagy; Microbiology/Virology
	Usnic Acid (Usniacin) 是地衣次生代谢产物，具有独特的二苯并呋喃骨架。它是一种抗菌剂、抗肿瘤剂和酶抑制剂。
T3384	Wedelolactone 蟛蜞菊内酯,IKK Inhibitor II	Apoptosis; NF-κB; Lipoxygenase; Caspase	Apoptosis; Metabolism; NF-κB; Proteases/Proteasome
	Wedelolactone (IKK Inhibitor II) 是来自旱莲草的一种天然产物，通过阻断 IκBα 的磷酸化和降解来抑制细胞中 NF-κB 介导的基因转录，具有抗癌，抗炎和抗氧化活性。
TN1149	6''-O-acetylsaikosaponin A	Others	Others
	6''-O-Acetylsaikosaponin A 是一种分离自柴胡根中的乙酰柴胡皂苷，表现出一定的破骨细胞抑制活性。
T3804	Neomangiferin Mangiferin 7-glucoside,新芒果苷	Phosphatase	Metabolism
	Neomangiferin (Mangiferin 7-glucoside) 是一种天然的 C-glucosyl xanthone，分离自干燥的Anemarrhena asphodeloides 的根茎中。它能够减轻大鼠高脂饮食诱导的非酒精性脂肪性肝病 (NAFLD)。
T3488	Tectorigenin 4',5,7-Trihydroxy-6-methoxyisoflavone,Tectorigenine,鸢尾黄酮,鸢尾黄素	Apoptosis	Apoptosis
	Tectorigenin (4',5,7-Trihydroxy-6-methoxyisoflavone) 是一种从葛根汤干燥的花中分离出来的植物异黄酮。
TN2143	3,7,4'-Trihydroxyflavone Resokaempferol,5-Deoxykampferol	DNA	DNA Damage/DNA Repair
	3,7,4'-Trihydroxyflavone(5-Deoxykampferol) 是从黄檀心材中分离得到的一种具有 DNA 断链活性的黄酮类化合物，可抑制 NF-κB 配体（RANKL）受体激活剂诱导的 RAW 264.7 细胞和骨髓巨噬细胞中的破骨细胞分化、肌动蛋白环形成和骨吸收。
T6S2099	Geraniin	Antioxidant; TNF	Apoptosis; oxidation-reduction
	Geraniin 是一种肿瘤坏死因子α释放抑制剂，其IC50值为 43 μM，具有抗肿瘤、抗炎和抗高血糖活性。
T6677	Sophocarpine	ERK; p38 MAPK; NF-κB; TLR; COX; HER; JNK; STAT	Angiogenesis; Immunology/Inflammation; JAK/STAT signaling; MAPK; Neuroscience; NF-κB; Stem Cells; Tyrosine Kinase/Adaptors
	Sophocarpine 是一种从传统草药苦参中提取的重要生物碱。苦参具有抗病毒、抗肿瘤和抗炎等多种药理作用。它通过多种机制显著抑制癌细胞的生长，具有抗肿瘤活性。
T16846	Sauristolactam Saurolactam	Others	Others
	Sauristolactam inhibits the receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclastogenesis and has the potential to inhibit osteoclast differentiation. Sauristolactam, a natural aristolactam isolated from aerial portions of Saururus Chi
TN4785	Picrasidine I	NF-κB; ROS; MAPK	Immunology/Inflammation; MAPK; NF-κB
	Picrasidine I has antiosteoclastogenic effect by inhibiting inflammation induced activation of MAPKs, NF-ÎºB and ROS generation followed by suppressing the gene expression of c-Fos and NFATc1 in osteoclast precursors.
T83033	Anti-osteoporosis agent-2
	Anti-osteoporosis agent-2 (Compound 10)为抗骨质疏松剂，能抑制RANKL诱导的破骨细胞分化。
TMA1743	Ergosterol peroxide	ERK; VEGFR; p38 MAPK; Wnt/beta-catenin; Akt; JAK; CDK; JNK; STAT; Antifection	Angiogenesis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; JAK/STAT signaling; MAPK; Microbiology/Virology; PI3K/Akt/mTOR signaling; Stem Cells; Tyrosine Kinase/Adaptors
	Ergosterol peroxide is an inhibitor of osteoclast differentiation, which has antiviral, trypanocidal, antitumor, and antiangiogenic actions, it can stimulate Foxo3a activity by inhibiting pAKT and c-Myc and activating pro-apoptotic protein Puma and Bax to
T27711	Kahweol Eicosanate J002075,J 002075,J-002075
	Kahweol Eicosanate is a semi-syntetic derivative of kahweol. Kahweol Eicosanate exhibits a wide variety of biological activities, including inducing cell cycle arrest and apoptosis in oral squamous cell carcinoma cells, inhibiting RANKL-induced osteoclast
TN3802	Dehydrodiconiferyl alcohol	Estrogen/progestogen Receptor	Endocrinology/Hormones
	Dehydrodiconiferyl alcohol （DHCA）是一种从葫芦中分离出来的木脂素，通过作为雌激素受体激动剂抑制破骨细胞分化和卵巢切除术诱导的骨质流失。
T79932	Eudebeiolide B Plebeiolide D	NF-κB	NF-κB
	Eudebeiolide B，一种自荔枝草分离得的化合物，能通过调控RANKL诱导的NF-κB、c-Fos及钙信号来抑制破骨细胞的生成，适用于研究与破骨细胞相关的疾病。
TN1663	Ganoderic acid DM 灵芝酸DM,灵芝酸 DM	PARP; Androgen Receptor; CDK	Cell Cycle/Checkpoint; Chromatin/Epigenetic; DNA Damage/DNA Repair; Endocrinology/Hormones
	Ganoderic acid DM is an antiandrogenic osteoclastogenesis inhibitor, it especially suppresses the expression of c-Fos and nuclear factor of activated T cells c1 (NFATc1), this suppression leads to the inhibition of dendritic cell-specific transmembrane pr
TN2533	1-Hydroxy-2,3,4,7-tetramethoxyxanthone	5-HT Receptor	GPCR/G Protein; Neuroscience
	1-Hydroxy-2,3,4,7-tetramethoxy-xanthone has vasodilatory action, it can cause vasodilation in the coronary artery pre-contracted with 1uM 5-hydroxytryptamine (5-HT), with the EC 50 value of 6.6±1.4 uM. 1-Hydroxy-2,3,4,7-tetramethoxyxanthone can effectivel
TN4094	Gallocatechin gallate	IL Receptor; NF-κB; ROS; MAPK; PPAR; Fatty Acid Synthase	DNA Damage/DNA Repair; Immunology/Inflammation; MAPK; Metabolism; NF-κB
	Gallocatechin gallate has strong antioxidative, and anti-obesity activities, it inhibits 3T3-L1 differentiation and lipopolysaccharide induced inflammation through MAPK and NF-ÎºB signaling; it also may have anti-diabetic effects by increasing sensitivity
TN2534	1-Hydroxy-2,3,5-trimethoxyxanthone	IκB/IKK; Calcium Channel; NOS; 5-HT Receptor; COX	GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience; NF-κB
	1-Hydroxy-2,3,5-trimethoxyxanthone (HM-1) has vasodilator action ,which involves both an endothelium-dependent mechanism involving NO and an endothelium-independent mechanism by inhibiting Ca(2+) influx through L-type voltage-operated Ca(2+) channels; a minor contribution to the effects of HM-1 may be related to inhibition of the protein kinase C-mediated release of intracellular Ca(2+) stores. HM-1,at the concentration of 1 ug/mL, can effectively inhibit the osteoclast differentiation in a co-c...

天然产物

Cat.No: T3816

Target: NF-κB, HIF/HIF Prolyl-Hydroxylase

Cat.No: TN5888

Target: Others

Skullcapflavone II

Cat.No: TN1040

Target: COX, Antibacterial, TGF-beta/Smad

Cat.No: TN2347

Synonym: 麻醉椒苦素,Methysticin

Target: Others

Cat.No: T2731

Synonym: Usniacin,松萝酸,地衣酸

Target: Antibacterial, Autophagy

Cat.No: T3384

Synonym: 蟛蜞菊内酯,IKK Inhibitor II

Target: Apoptosis, NF-κB, Lipoxygenase, Caspase

6''-O-acetylsaikosaponin A

Cat.No: TN1149

Target: Others

Cat.No: T3804

Synonym: Mangiferin 7-glucoside,新芒果苷

Target: Phosphatase

Cat.No: T3488

Synonym: 4',5,7-Trihydroxy-6-methoxyisoflavone,Tectorigenine,鸢尾黄酮,鸢尾黄素

Target: Apoptosis

3,7,4'-Trihydroxyflavone

Cat.No: TN2143

Synonym: Resokaempferol,5-Deoxykampferol

Target: DNA

Cat.No: T6S2099

Target: Antioxidant, TNF

Cat.No: T6677

Target: ERK, p38 MAPK, NF-κB, TLR, COX, HER, JNK, STAT

Cat.No: T16846

Synonym: Saurolactam

Target: Others

Cat.No: TN4785

Target: NF-κB, ROS, MAPK

Anti-osteoporosis agent-2

Cat.No: T83033

Ergosterol peroxide

Cat.No: TMA1743

Target: ERK, VEGFR, p38 MAPK, Wnt/beta-catenin, Akt, JAK, CDK, JNK, STAT, Antifection

Kahweol Eicosanate

Cat.No: T27711

Synonym: J002075,J 002075,J-002075

Dehydrodiconiferyl alcohol

Cat.No: TN3802

Target: Estrogen/progestogen Receptor

Cat.No: T79932

Synonym: Plebeiolide D

Target: NF-κB

Ganoderic acid DM

Cat.No: TN1663

Synonym: 灵芝酸DM,灵芝酸 DM

Target: PARP, Androgen Receptor, CDK

1-Hydroxy-2,3,4,7-tetramethoxyxanthone

Cat.No: TN2533

Target: 5-HT Receptor

Gallocatechin gallate

Cat.No: TN4094

Target: IL Receptor, NF-κB, ROS, MAPK, PPAR, Fatty Acid Synthase

1-Hydroxy-2,3,5-trimethoxyxanthone

Cat.No: TN2534

Target: IκB/IKK, Calcium Channel, NOS, 5-HT Receptor, COX

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