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500

抑制剂 & 化合物

29

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T38766L	Histone H3 (1-35) acetate	Others	Others
	Histone H3 (1-35) acetate 是组蛋白 H3 的 35 个残基肽。组蛋白 H3 是一种重要的蛋白质，在基因的动态和长期调控中发挥作用。
T11563	Histone Acetyltransferase Inhibitor II	Epigenetic Reader Domain; Histone Acetyltransferase	Chromatin/Epigenetic
	Histone Acetyltransferase Inhibitor II 是一种选择性的细胞渗透性 p300 组蛋白乙酰转移酶抑制剂，IC50值为 5 µM。它在哺乳动物细胞中具有抗乙酰化酶活性，可用于癌症研究。
T2157	M344 MS 344,Histone Deacetylase Inhibitor III	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	M344 (Histone Deacetylase Inhibitor III) 是一种组蛋白去乙酰化酶抑制剂，IC50为 100 nM。
T38766	Histone H3 (1-35) Histone H3 (1-35)
	Histone H3 (1-35) is a 35-residue peptide derived from histone H3, which is a key member of the five main histones participating in the formation of chromatin within eukaryotic cells.
T38785	Histone H3 (21-44) Histone H3 (21-44)
	Histone H3 (21-44), derived from a sequence of 21-44 amino acids of histone H3, is commonly employed as a substrate, particularly for protein arginine methyltransferase assays, where methylation activity is being examined.
T41019	Histone H1-derived Peptide Histone H1-derived Peptide
	Histone H1-derived peptide is a phosphopeptide with peptide substrates that consist of a sequence aligned with the optimal recognition motif for cyclin-dependent kinases (CDKs).
T40993	Histone H3 (1-21) Histone H3 (1-21)
	Histone H3 (1-21) is a truncated form of the Histone H3 protein consisting of amino acids 1 to 21. It serves as a common substrate for methyltransferase assays targeting Histone 3 at lysine 4 and lysine 9, as well as for acetyltransferase assays targeting Histone 3 at lysine 9 and lysine 14.
T39580	Histone H3 (23-34) Histone H3 (23-34)
	Histone H3 (23-34) is a peptide consisting of amino acid residues 23 to 34 of the histone H3 protein. This peptide specifically includes lysine residues at positions 23 and 27, which can undergo methylation and acetylation modifications.
T40407	Histone H3 (5-23) Histone H3 (5-23)
	Histone H3 (5-23), a derivative of histone H3 consisting of amino acids 5-23, serves as a substrate for histone acetyltransferase (HAT) assays.
T38784	Histone H3 (1-25), amide Histone H3 (1-25), amide
	Histone H3 (1-25), amide is a N-terminal peptide fragment of histone H3 that serves as a substrate for histone methyltransferases (HMTs). It can be utilized to identify the substrate for HMTs. Compared to histone H3 (15-39) and full-length histone H3, Histone H3 (1-25), amide proves to be more efficient as a substrate for HMT G9a.
T3206	NKL 22 Histone Deacetylase Inhibitor IV,PAOA	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	NKL 22 (Histone Deacetylase Inhibitor IV) 是一种有效的选择性组蛋白脱乙酰基酶(HDAC) 抑制剂，对 HDAC2/4/5/7/8 具有选择性，抑制HDAC1和HDAC3的IC50值分别为 199 和 69 nM。它可改善亨廷顿氏病转基因小鼠的疾病表型和转录异常。
T41061	Histone H3 (116-136), C116-136 Histone H3 (116-136), C116-136
	Histone H3 (116-136), C116-136 is a peptide consisting of amino acids 116 to 136, which spans the C-terminus of histone H3.
T36980	Histone H3K27Me1 (23-34) (trifluoroacetate salt) Histone H3K27Me1 (23-34) (trifluoroacetate salt)
	Histone H3K27Me1 (23-34) is a peptide fragment of histone H3 that corresponds to amino acid residues 24-35 of the human histone H3.1 and H3.2 sequences. Monomethylation of histone H3 at lysine 27 is associated with actively transcribed genes and positively correlates with H3K36 trimethylation. Levels of H3K27Me1 are increased in tumor tissue isolated from patients with metastatic hormone-na ve and castration-resistant prostate cancer. Histone H3K27Me1 (23-34) has been used in epitope mapping of ...
T77560	Histone acetyltransferase p300 Inhibitor 4c	Carbonic Anhydrase; AChE	Metabolism; Neuroscience
	Histone acetyltransferase p300 Inhibitor 4c 是2-氨基噻唑衍生物，Histone acetyltransferase p300 Inhibitor 4c 对 hCA I 、hCA II、AChE 和 BChE 具有抑制作用，Ki 值为 0.008 ± 0.001 、 0.124 ± 0.017、0.129 ± 0.030 和 0.083 ± 0.041 μM。
T36979	Histone H3 (21-44)-GK-biotin amide (trifluoroacetate salt) Histone H3 (21-44)-GK-biotin amide (trifluoroacetate salt)
	Histone H3 (21-44)-GK-biotin is a peptide fragment of histone H3 that corresponds to amino acid residues 22-45 of the human histone H3.3 sequence and is biotinylated via a C-terminal GK linker. Unlike histone H3.1 and H3.2, the histone H3.3 variant contains a serine residue at position 31 that is phosphorylated during late prometaphase and metaphase of mitosis. Histone H3 (21-44) also contains lysine residues at positions 23, 27, and 36 that are subject to methylation and acetylation, all of whi...
T36576	Histone H3 (21-44)-GK-biotin (trifluoroacetate salt) Histone H3 (21-44)-GK-biotin (trifluoroacetate salt)
	Histone H3 (21-44)-GK-biotin is a peptide fragment of histone H3 that corresponds to amino acid residues 22-45 of the human histone H3.1 and 3.2 sequences and is biotinylated via a C-terminal GK linker. Histone H3 (21-44) contains a lysine residue at position 23 that is subject to acetylation, an arginine at position 26 subject to methylation, and a serine at position 28 subject to phosphorylation, as well as lysine residues at positions 27 and 36 that are subject to methylation and acetylation....
T36095	Histone H2BK12ac (1-22)-GGK-biotin amide (trifluoroacetate salt) Histone H2BK12ac (1-22)-GGK-biotin amide (trifluoroacetate salt)
	Histone H2BK12ac (1-22)-GGK-biotin amide (trifluoroacetate salt) 可用于生命科学领域的相关研究，其产品编号为 T36095。
T3193	Pimelic diphenylamide 106 Histone Deacetylase Inhibitor VII,TC-H 106,RGFA-8	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Pimelic diphenylamide 106 (RGFA-8) 是一种缓慢和紧密结合的I 类HDAC 抑制剂，对HDAC1、 2和3的IC50值分别150、760和370 nM。
T36577	K-Biotin-W-Histone H2B (108-125) (trifluoroacetate salt) K-Biotin-W-Histone H2B (108-125) (trifluoroacetate salt)
	Histone H2B (108-125) is a peptide fragment of histone H2B that corresponds to amino acid residues 109-126 of the human histone H2B sequence. It contains an N-terminal biotinylated lysine followed by a tryptophan linker. Histone H2B can be modified by addition of an O-linked N-acetylglucosamine (GlcNAc) moiety to the serine residue at position 112, which promotes monoubiquitination of the lysine at position 120.1 Both of these modifications are associated with active transcription. Histone H2B a...
TP1536	Histone H4 (2-21)
	Histone H4 (2-21) is a pivotal core histone involved in the process of chromatinization specific to the genomes of herpes simplex virus 1 (HSV-1).
TP2257	Histone-H2A-(107-122)-Ac-OH	Others	Others
	Histone-H2A-(107-122)-Ac-OH is a peptide with the sequence Ac-Gly-Val-Leu-Pro-Asn-Ile-Gln-Ala-Val-Leu-Leu-Pro-Lys-Lys-Thr-Glu-OH, MW= 1762.1. Histone H2A is one of the five main histone proteins involved in the structure of chromatin in eukaryotic cells.
T64592	Histone H3 Antibody #9715R
	Histone H3 Antibody #9715R 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T64592。
T16435	PBIT	Histone Demethylase; Histone Methyltransferase	Chromatin/Epigenetic
	PBIT 是一种特异性 Jumonji/AT 富集互作结构域 1 抑制剂，抑制JARID1A 和JARID1C，IC50分别为 6 和 4.9 μM。它抑制JARID1B(KDM5B 或PLU1) 组蛋白去甲基化酶，IC50值约为 3 μM。
T11807	L002	Others; Histone Acetyltransferase; STAT	Chromatin/Epigenetic; JAK/STAT signaling; Others; Stem Cells
	L002 是一种细胞可渗透的，可逆特定性乙酰转移酶 p300(KAT3B)抑制剂，IC50为 1.98 μM。它结合乙酰辅酶 A 口袋并竞争性抑制 FATp300 催化结构域，阻断组蛋白乙酰化和 p53 乙酰化，且抑制 STAT3 激活，有用于高血压引起的心脏肥大和纤维化的研究潜力。
T3499	Remodelin	Histone Acetyltransferase	Chromatin/Epigenetic
	Remodelin 是一种特异性有效的乙酰转移酶蛋白 NAT10 抑制剂。
T9243	PFI-90	Histone Demethylase; Others	Chromatin/Epigenetic; Others
	PFI-90 是组蛋白去甲基化酶 (KDM3B) 的选择性抑制剂，可抑制 PAX3-FOXO1 的作用。它具有抗肿瘤活性的潜力，可诱导细胞凋亡和成肌分化，导致细胞死亡增加。
T8344	CPTH2	Apoptosis; Histone Acetyltransferase	Apoptosis; Chromatin/Epigenetic
	CPTH2 是一种组蛋白乙酰基转移酶抑制剂。它选择性地抑制Gcn5对组蛋白 H3 的乙酰化，通过抑制乙酰转移酶p300 (KAT3B)诱导凋亡并降低透明细胞肾癌细胞系的侵袭性。
T5347	CXD101 CXD-101	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	CXD101 是一种选择性和具有口服活性的 I 类HDAC 抑制剂，有抗肿瘤活性，对HDAC1、HDAC2和HDAC3的IC50分别为 63、570 和 550 nM。
T6327	Tubacin	Virus Protease; HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair; Microbiology/Virology
	Tubacin 是一种高效、选择性、可逆、可渗透细胞的 HDAC6 抑制剂，IC50 为 4 nM，选择性是 HDAC1 的约 350 倍。
T7664	Pyroxamide	Apoptosis; HDAC	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair
	Pyroxamide 是一种组蛋白脱乙酰基酶 1 抑制剂，IC50为 100 nM。它可以诱导白血病细胞凋亡和细胞周期停滞。
T76381	H1-7 (histone H1 phosphorylation site), PKA Substrate
	H1-7 (histone H1 phosphorylation site),PKASubstrate 是一种合成多肽，可作为PKA 底物。
T1819	Nexturastat A	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Nexturastat A 是一种有效且特异性的 HDAC6 抑制剂，IC50: 5 nM。它的选择性是其他 HDAC 的 190 倍以上。
T8778	TTK21	Epigenetic Reader Domain	Chromatin/Epigenetic
	TTK21 是 CBP/p300 组蛋白乙酰转移酶活性的激活剂，与葡萄糖基碳纳米球结合时，可通过血脑屏障，对成人大脑神经发生和长期记忆功能有益。
T6055	Quisinostat 奎诺司他,JNJ-26481585	Apoptosis; HDAC; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair
	Quisinostat (JNJ-26481585) 是一种高效的，具有口服活性的 pan-HDAC 抑制剂，对 HDAC1、HDAC2、HDAC4、HDAC10、HDAC11 作用的 IC50值范围为 0.11-0.64 nM。它在成神经细胞瘤中能诱导自噬，具有广泛的抗肿瘤活性。
T9745	Elevenostat	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Elevenostat 是有效的HDAC11选择性抑制剂 (IC50=0.235 µM)。Elevenostat 具有抗多发性骨髓瘤的活性。
T64611	Acetyl-Histone H3 (Lys9) (C5B11) Rabbit mAb #9649R
	Acetyl-Histone H3 (Lys9) (C5B11) Rabbit mAb #9649R 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T64611。
T5830	SKLB-23bb	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	SKLB-23bb 是一种口服生物可利用的 HDAC6 选择性抑制剂，还具有微管破坏能力，IC50为 17 nM。它比HDAC1和HDAC8选择性分别高 25 倍和 200 倍，IC50为 422 和 3398 nM。
T12098	MOZ-IN-2	Histone Acetyltransferase	Chromatin/Epigenetic
	MOZ-IN-2 是一种MOZ，属于组蛋白乙酰转移酶的抑制剂，IC50值为 125 nM。
T6900	MS023	Histone Methyltransferase	Chromatin/Epigenetic
	MS023 是一种有效的、选择性的、细胞活性的 I 型 PRMT 抑制剂，对 PRMT1、PRMT3、PRMT4、PRMT6和 PRMT8的 IC50分别为 30、119、83、4 和 5 nM。
T7089	SGC2085	Histone Methyltransferase	Chromatin/Epigenetic
	SGC2085是一种高效选择性CARM1抑制剂，IC50值为50 nM。
T15201	MAK683	Histone Methyltransferase	Chromatin/Epigenetic
	MAK683 是胚胎外胚层发育 (EED) 抑制剂。在 EED Alphascreen 结合、LC-MS 和 ELISA 测定中，IC50值为 59、89 和 26 nM。
T10205	A-395	Histone Methyltransferase	Chromatin/Epigenetic
	A-395 是一种多梳抑制复合物 2 (PRC2) 蛋白质-蛋白质相互作用的拮抗剂，可有效抑制三聚体 PRC2 复合物 (EZH2-EED-SUZ12)，IC50为 18 nM。
T3084	SGC707	Histone Methyltransferase	Chromatin/Epigenetic
	SGC707 是 PRMT3化学探针，是一种有效的、选择性的、细胞活性的 PRMT3 变构抑制剂，IC50值为 31 nM。
T5322	BCI-121	Histone Methyltransferase	Chromatin/Epigenetic
	BCI-121是一种底物竞争性 SMYD3 抑制剂，可抑制癌细胞的增殖。
T16129	MPI_5a	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	MPI_5a 是高效的 HDAC6选择性抑制剂，IC50=36 nM，对其他 HDAC 酶几乎无抑制作用。MPI_5a 抑制细胞内酰基微管蛋白积累， IC50为 210 nM。
T1905	EPZ005687	Histone Methyltransferase	Chromatin/Epigenetic
	EPZ005687 是一种选择性EZH2抑制剂，Ki 值为 24 nM，对其选择性是对 EZH1 的 50 倍，对其他 15 种甲基转移酶的 500 倍。
T4021	UNC3866	Histone Methyltransferase	Chromatin/Epigenetic
	UNC3866 CBX7-H3 相互作用的有效拮抗剂，IC50为 66±1.2 nM。
T2435	EPZ011989	Histone Methyltransferase	Chromatin/Epigenetic
	EPZ011989是一种高选择性可口服的 EZH2抑制剂，对wt EZH2以及EZH2突变型Ki 值<3nM。
T9584	UNC6934	Others; Histone Methyltransferase	Chromatin/Epigenetic; Others
	UNC6934 是一种针对 NSD2 的 N 端 PWWP (PWWP1) 结构域的化学探针，可定位核仁。
T1775	GSK503	Histone Methyltransferase	Chromatin/Epigenetic
	GSK503是一种高效特异性EZH2甲基转移酶抑制剂，Ki 值为3到27 nM，具有潜在的抗肿瘤活性。

化合物

Histone H3 (1-35) acetate

Cat.No: T38766L

Target: Others

Histone Acetyltransferase Inhibitor II

Cat.No: T11563

Target: Epigenetic Reader Domain, Histone Acetyltransferase

Cat.No: T2157

Synonym: MS 344,Histone Deacetylase Inhibitor III

Target: HDAC

Histone H3 (1-35)

Cat.No: T38766

Synonym: Histone H3 (1-35)

Histone H3 (21-44)

Cat.No: T38785

Synonym: Histone H3 (21-44)

Histone H1-derived Peptide

Cat.No: T41019

Synonym: Histone H1-derived Peptide

Histone H3 (1-21)

Cat.No: T40993

Synonym: Histone H3 (1-21)

Histone H3 (23-34)

Cat.No: T39580

Synonym: Histone H3 (23-34)

Histone H3 (5-23)

Cat.No: T40407

Synonym: Histone H3 (5-23)

Histone H3 (1-25), amide

Cat.No: T38784

Synonym: Histone H3 (1-25), amide

Cat.No: T3206

Synonym: Histone Deacetylase Inhibitor IV,PAOA

Target: HDAC

Histone H3 (116-136), C116-136

Cat.No: T41061

Synonym: Histone H3 (116-136), C116-136

Histone H3K27Me1 (23-34) (trifluoroacetate salt)

Cat.No: T36980

Synonym: Histone H3K27Me1 (23-34) (trifluoroacetate salt)

Histone acetyltransferase p300 Inhibitor 4c

Cat.No: T77560

Target: Carbonic Anhydrase, AChE

Histone H3 (21-44)-GK-biotin amide (trifluoroacetate salt)

Cat.No: T36979

Synonym: Histone H3 (21-44)-GK-biotin amide (trifluoroacetate salt)

Histone H3 (21-44)-GK-biotin (trifluoroacetate salt)

Cat.No: T36576

Synonym: Histone H3 (21-44)-GK-biotin (trifluoroacetate salt)

Histone H2BK12ac (1-22)-GGK-biotin amide (trifluoroacetate salt)

Cat.No: T36095

Synonym: Histone H2BK12ac (1-22)-GGK-biotin amide (trifluoroacetate salt)

Pimelic diphenylamide 106

Cat.No: T3193

Synonym: Histone Deacetylase Inhibitor VII,TC-H 106,RGFA-8

Target: HDAC

K-Biotin-W-Histone H2B (108-125) (trifluoroacetate salt)

Cat.No: T36577

Synonym: K-Biotin-W-Histone H2B (108-125) (trifluoroacetate salt)

Histone H4 (2-21)

Cat.No: TP1536

Histone-H2A-(107-122)-Ac-OH

Cat.No: TP2257

Target: Others

Histone H3 Antibody #9715R

Cat.No: T64592

Cat.No: T16435

Target: Histone Demethylase, Histone Methyltransferase

Cat.No: T11807

Target: Others, Histone Acetyltransferase, STAT

Cat.No: T3499

Target: Histone Acetyltransferase

Cat.No: T9243

Target: Histone Demethylase, Others

Cat.No: T8344

Target: Apoptosis, Histone Acetyltransferase

Cat.No: T5347

Synonym: CXD-101

Target: HDAC

Cat.No: T6327

Target: Virus Protease, HDAC

Cat.No: T7664

Target: Apoptosis, HDAC

H1-7 (histone H1 phosphorylation site), PKA Substrate

Cat.No: T76381

Cat.No: T1819

Target: HDAC

Cat.No: T8778

Target: Epigenetic Reader Domain

Cat.No: T6055

Synonym: 奎诺司他,JNJ-26481585

Target: Apoptosis, HDAC, Autophagy

Cat.No: T9745

Target: HDAC

Acetyl-Histone H3 (Lys9) (C5B11) Rabbit mAb #9649R

Cat.No: T64611

Cat.No: T5830

Target: HDAC

Cat.No: T12098

Target: Histone Acetyltransferase

Cat.No: T6900

Target: Histone Methyltransferase

Cat.No: T7089

Target: Histone Methyltransferase

Cat.No: T15201

Target: Histone Methyltransferase

Cat.No: T10205

Target: Histone Methyltransferase

Cat.No: T3084

Target: Histone Methyltransferase

Cat.No: T5322

Target: Histone Methyltransferase

Cat.No: T16129

Target: HDAC

Cat.No: T1905

Target: Histone Methyltransferase

Cat.No: T4021

Target: Histone Methyltransferase

Cat.No: T2435

Target: Histone Methyltransferase

Cat.No: T9584

Target: Others, Histone Methyltransferase

Cat.No: T1775

Target: Histone Methyltransferase

Cat. No.	Product Name	Target	Signaling Pathways
T8201	Gambogenic acid	Histone Methyltransferase	Chromatin/Epigenetic
	Gambogenic acid 是黄藤中的一种有效成分，具有抗癌活性。它是特异性EZH2抑制剂，与 EZH2-SET 结构域的 Cys668 位点共价结合，诱导 EZH2 泛素化。
T6803	Chaetocin 毛壳素	Histone Methyltransferase; Antibacterial; Antibiotic	Chromatin/Epigenetic; Microbiology/Virology
	Chaetocin 特异性抑制组蛋白甲基转移酶(HMT) SU(VAR)3-9，IC50值为0.6 μM。它还可抑制硫氧还蛋白还原酶，IC50值为4 μM。
TQ0207	Sulforaphane 萝卜硫素	Apoptosis; Nrf2; HDAC	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Immunology/Inflammation
	Sulforaphane 是存在于多种蔬菜中的一种天然异硫氰酸酯。它可以激活Nrf2，并通过 AMPK 依赖性信号传导抑制高糖诱导的胰腺癌。它增加肿瘤抑制蛋白的转录并抑制组蛋白脱乙酰酶的活性，具有抗癌和抗炎活性。
T3719	Daminozide Succinic Acid,DMASA,Aminozide,丁酰肼	Histone Demethylase	Chromatin/Epigenetic
	Daminozide (Succinic Acid) 是一种植物生长调节剂，选择性地抑制 KDM2/7 JmjC 亚家族，对PHF8、KDM2A 和KIAA1718的IC50值分别为 0.55、1.5 和 2.1 μM。
T2266	SantacruzaMate A CAY-10683	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	SantacruzaMate A (CAY-10683) 是一种高效选择性的HDAC2抑制剂，IC50为 119 pM。
T7052	Gnetol	Tyrosinase; COX; HDAC; AChR	Chromatin/Epigenetic; DNA Damage/DNA Repair; Immunology/Inflammation; Neuroscience; Proteases/Proteasome
	Gnetol 是从买麻藤的根中分离出来的一种酚类。它是酪氨酸酶抑制剂，对鼠酪氨酸酶的 IC50为 4.5 μM，可抑制黑色素的生物合成。它有效抑制 COX-1和 HDAC，具有抗氧化、抗增殖、抗癌和保肝活性，还具有浓度依赖性的 α-淀粉酶、α-葡萄糖苷酶和脂肪形成活性。
T6270	Trichostatin A 曲古柳菌素A,曲古抑菌素A,TSA	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Trichostatin A (TSA) 属于二烯异羟肟酸类的天然衍生物。Trichostatin A 是一种组蛋白去乙酰化酶抑制剂 (IC50=1.8 nM)，具有可逆性和特异性。Trichostatin A 导致核心组蛋白过度乙酰化，从而调节染色质结构。
T11366	Garcinol	Apoptosis; Endogenous Metabolite; Histone Acetyltransferase; AChR; AChE	Apoptosis; Chromatin/Epigenetic; Metabolism; Neuroscience
	Garcinol 是一种从印度藤黄提取的聚异戊二烯基二苯甲酮，对乙酰胆碱酯酶和丁酰胆碱酯酶具有抗胆碱酯酶的特性，IC50分别为 0.66 µM 和 7.39 µM。它还抑制组蛋白乙酰转移酶和 p300/CPB 相关因子，具有抗炎和抗癌活性。
TN1150	Procyanidin B3 原花青素B3,原花青素 B3	Histone Acetyltransferase	Chromatin/Epigenetic
	Procyanidin B3 是从葡萄中提取的一种黄酮类天然产物，是组蛋白乙酰转移酶特异性抑制剂，可与 p300的其他位点而非活性位点结合，选择性抑制 p300 介导的 androgen 受体乙酰化。
T5368	Eicosapentaenoic Acid	Histone Demethylase; Others; Endogenous Metabolite	Chromatin/Epigenetic; Metabolism; Others
	Eicosapentaenoic Acid 是一种 ω-3 脂肪酸。
TN1911	Marein 马里苷,马里甙	transporter; Akt; HDAC; AMPK	Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; Metabolism; PI3K/Akt/mTOR signaling
	Marein 能通过CaMKK/AMPK/GLUT1促进葡萄糖摄取，IRS/Akt/GSK-3β增加糖原合成，并通过Akt/FoxO1减少糖异生，从而改善 HepG2 细胞中高葡萄糖诱导的胰岛素抵抗。它对甲基乙二醛诱导的 PC12 细胞损伤具有神经保护作用，还有抗氧化、降压、降血脂和抗糖尿病作用。
T6389	Anacardic Acid 漆树酸,6-pentadecylsalicylic Acid,Hydroginkgolic acid	Others; Epigenetic Reader Domain; Histone Acetyltransferase; Antibacterial	Chromatin/Epigenetic; Microbiology/Virology; Others
	Anacardic Acid (6-pentadecylsalicylic Acid) 是从腰果壳中提取液中分离到的酸类物质，是一种组蛋白乙酰转移酶抑制剂，对 p300 和 PCAF 的 IC50值分别为 ∼8.5 μM 和 ∼5 μM。
T3753	Sinapinic Acid Sinapic acid,芥子酸,Synapoic acid	Apoptosis; RAAS; Reactive Oxygen Species; HDAC	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Endocrinology/Hormones; Immunology/Inflammation; Metabolism; NF-κB
	Sinapinic Acid (Synapoic acid) 是从 Hydnophytum formicarumJack. 根中分离到的酚类，是HDAC 抑制剂，对ACE-I 的活性也有抑制作用。它有抗肿瘤活性，诱导肿瘤细胞凋亡，具有抗氧化、抗糖尿病的作用。
T6S0033	Crotonoside 巴豆苷；异鸟苷,巴豆苷,Isoguanosine,2-HYDROXYADENOSINE	Others; FLT; HDAC	Angiogenesis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Others; Tyrosine Kinase/Adaptors
	Crotonoside (Isoguanosine) 是从中草药巴豆中分离出来的一种天然产物。它抑制 FLT3 和 HDAC3/6，有治疗急性髓性白血病 (AML)的研究潜力。
T0065	Acetaminophen 对乙酰氨基酚,醋氨酚,4-Acetamidophenol,4'-Hydroxyacetanilide,APAP,Paracetamol	COX; Endogenous Metabolite; Histone Acetyltransferase	Chromatin/Epigenetic; Immunology/Inflammation; Metabolism; Neuroscience
	Acetaminophen (APAP) 是一种 COX 抑制剂，抑制 COX-1 和 COX-2 (IC50=113.7/25.8 μM)。Acetaminophen 具有解热镇痛活性，以及较弱的抗炎活性。
T1516	Curcumin Diferuloylmethane,Natural Yellow 3,姜黄素,Indian Saffron,Turmeric yellow	Mitophagy; Epigenetic Reader Domain; Ferroptosis; Influenza Virus; Nrf2; Histone Acetyltransferase; HDAC; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; Immunology/Inflammation; Microbiology/Virology
	Curcumin (Natural Yellow 3) 属于酚类天然产物，是一种组蛋白乙酰化转移酶 p300/CREB 的抑制剂 (IC50=25 μM)，具有特异性。Curcumin 具有抗肿瘤、抗炎和抗氧化等多种药理活性。
T7064	Valproic Acid Sodium valproate,2-Propylpentanoic Acid,丙戊酸,VPA,Depakine,2-Propylvaleric Acid	Mitophagy; Gamma-secretase; HIV Protease; GABA Receptor; Sodium Channel; HDAC; Autophagy	Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience; Proteases/Proteasome; Stem Cells
	Valproic Acid (2-Propylpentanoic Acid) 是一种 HDAC 抑制剂，可抑制 HDAC1 活性，诱导 HDAC2 降解，具有口服活性。Valproic Acid 可以用于癫痫和躁郁症的研究。
T64353	4-tert-Octylphenol	Endogenous Metabolite	Metabolism
	4-tert-Octylphenol 是一种干扰内分泌的化学物质及雌激素药物，能诱导子代小鼠脑神经元祖细胞的凋亡，并通过减少溴脱氧尿苷（BrdU）、有丝分裂标志物Ki67以及磷酸组蛋白H3（p-Histone-H3）的表达，导致神经元祖细胞的增殖减少。这种物质不仅会干扰小鼠的大脑发育，还会影响其行为。
T3878	Raddeanin A NSC382873,竹节香附素A,Anemodeanin A,Raddeanin R3	Apoptosis; HDAC	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair
	Raddeanin A (NSC-382873) 是竹节香附中的一种天然三萜皂苷，可抑制组蛋白去乙酰化酶，具有很强的抗血管生成能力和抗肿瘤活性。
T14305	Apicidin OSI 2040	Apoptosis; HDAC; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair
	Apicidin (OSI 2040) 是组蛋白去乙酰化酶（HDAC）抑制剂，具有抗寄生虫活性和抗增殖活性。Apicidin 通过减少 APP/PS1 小鼠中的 Abeta 负荷来减轻记忆缺陷，抑制细胞生长增殖，诱导细胞凋亡和自噬，可用于研究白血病。
T37067	9-hydroxy Stearic Acid	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	9-hydroxy Stearic Acid 是一种羟基脂肪酸，是9-PAHSA 的活性代谢物。9-hydroxy Stearic Acid 是由9-PAHSA 通过肝脏和胰腺的羧基酯脂肪酶形成的。9-hydroxy Stearic Acid (5 μM)抑制HT-29结肠癌细胞裂解物中组蛋白去乙酰化酶1 (HDAC1)的表达。3 .当浓度为100 μM.1时，可抑制HT-29细胞的增殖，并诱导细胞周期阻滞于G0/ g1期。
TN1567	Delphinidin chloride	Estrogen Receptor/ERR; VEGFR	Angiogenesis; Endocrinology/Hormones; Tyrosine Kinase/Adaptors
	Delphinidin chloride 是一种花青素，是一种可从浆果和红酒中分离得到的天然植物色素，是某些花青素的前体。Delphinidin chloride 诱导血管内皮释放一氧化氮，引起血管松弛。在1 ~ 40 μM 剂量下，对上皮生长因子受体的信号传导和雌激素受体α的表达有抑制作用，与细胞凋亡和自噬有关。Delphinidin chloride 能调节 JAK/STAT3 和 MAPKinase 信号传导。Delphinidin 还能抑制 p300/CBP 的组蛋白乙酰转移酶活性(IC50 在约为30 μM)
T13749	L-2-Hydroxyglutaric acid (S)-2-Hydroxyglutaric acid	Others	Others
	L-2-Hydroxyglutaric acid, an epigenetic modifier and potential oncometabolite in renal cancer, impedes mitochondrial creatine kinase (Mi-CK) activity, exhibiting Km and Ki values of 2.52 mM and 11.13 mM, respectively. Additionally, it obstructs histone demethylases, thereby encouraging histone methylation.
T70778	Depudecin
	Depudecin is a polyketide obtained from the fungus Alternaria brassicicola and having a highly unusual structure of an 11-carbon chain containing two epoxides and six stereogenic centres. It is an inhibitor of histone deacetylase (HDAC) both in vivo and in vitro and also exhibits anti-angiogenic activity.
T75767	Parasin I TFA
	Parasin I (TFA) 是一种含有19个氨基酸残基的多肽，源自鲶鱼皮肤中分离出的组蛋白H2A，具备抗菌功能。
T36797	1-Alaninechlamydocin
	1-Alaninechalmydocin is a fungal metabolite originally isolated from a Great Lakes-derived Tolypocladium sp. and an inhibitor of histone deacetylases (HDACs). It reduces total HDAC activity in HeLa cell lysates in a concentration-dependent manner. 1-Alaninechlamydocin reduces proliferation of MIA PaCa-2, PANC-1, and hTERT-HPNE cells (GI50s = 5.3, 14, and 2.0 nM, respectively).
TN2646	16-Hydroxycleroda-3,13-dien-15,16-olide	Autophagy	Autophagy
	16-Hydroxycleroda-3,13-dien-15,16-olide, and prodigiosin are presented as candidates for autophagy inducers that can trigger cell death in a supplement or alternative medicine for cancer therapy. 16-Hydroxycleroda-3,13-dien-15,16-olide regulates the expre
TN3070	4beta-Hydroxywithanolide E	PARP; HSP; NF-κB; COX	Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Neuroscience; NF-κB
	4beta-Hydroxywithanolide E(4bHWE) can inhibit the growth of colon cancer monolayer and spheroid cultures, it assert its anti-tumor activity in carcinogenic progression and develop into a dietary chemopreventive agent, it affects alternative splicing by mo
T5066	Nε,Nε,Nε-Trimethyllysine chloride Lys(Me)3-OH Chloride,Nε,Nε,Nε-Trimethyllysine hydrochloride	Others; Endogenous Metabolite	Metabolism; Others
	Nε,Nε,Nε-Trimethyllysine chloride (Lys(Me)3-OH Chloride) 是肠道菌群依赖性形成 N,N,N-trimethyl-5-aminovaleric acid (TMAVA) 的前体。

天然产物

Gambogenic acid

Cat.No: T8201

Target: Histone Methyltransferase

Cat.No: T6803

Synonym: 毛壳素

Target: Histone Methyltransferase, Antibacterial, Antibiotic

Cat.No: TQ0207

Synonym: 萝卜硫素

Target: Apoptosis, Nrf2, HDAC

Cat.No: T3719

Synonym: Succinic Acid,DMASA,Aminozide,丁酰肼

Target: Histone Demethylase

SantacruzaMate A

Cat.No: T2266

Synonym: CAY-10683

Target: HDAC

Cat.No: T7052

Target: Tyrosinase, COX, HDAC, AChR

Cat.No: T6270

Synonym: 曲古柳菌素A,曲古抑菌素A,TSA

Target: HDAC

Cat.No: T11366

Target: Apoptosis, Endogenous Metabolite, Histone Acetyltransferase, AChR, AChE

Cat.No: TN1150

Synonym: 原花青素B3,原花青素 B3

Target: Histone Acetyltransferase

Eicosapentaenoic Acid

Cat.No: T5368

Target: Histone Demethylase, Others, Endogenous Metabolite

Cat.No: TN1911

Synonym: 马里苷,马里甙

Target: transporter, Akt, HDAC, AMPK

Cat.No: T6389

Synonym: 漆树酸,6-pentadecylsalicylic Acid,Hydroginkgolic acid

Target: Others, Epigenetic Reader Domain, Histone Acetyltransferase, Antibacterial

Cat.No: T3753

Synonym: Sinapic acid,芥子酸,Synapoic acid

Target: Apoptosis, RAAS, Reactive Oxygen Species, HDAC

Cat.No: T6S0033

Synonym: 巴豆苷；异鸟苷,巴豆苷,Isoguanosine,2-HYDROXYADENOSINE

Target: Others, FLT, HDAC

Cat.No: T0065

Synonym: 对乙酰氨基酚,醋氨酚,4-Acetamidophenol,4'-Hydroxyacetanilide,APAP,Paracetamol

Target: COX, Endogenous Metabolite, Histone Acetyltransferase

Cat.No: T1516

Synonym: Diferuloylmethane,Natural Yellow 3,姜黄素,Indian Saffron,Turmeric yellow

Target: Mitophagy, Epigenetic Reader Domain, Ferroptosis, Influenza Virus, Nrf2, Histone Acetyltransferase, HDAC, Autophagy

Cat.No: T7064

Synonym: Sodium valproate,2-Propylpentanoic Acid,丙戊酸,VPA,Depakine,2-Propylvaleric Acid

Target: Mitophagy, Gamma-secretase, HIV Protease, GABA Receptor, Sodium Channel, HDAC, Autophagy

4-tert-Octylphenol

Cat.No: T64353

Target: Endogenous Metabolite

Cat.No: T3878

Synonym: NSC382873,竹节香附素A,Anemodeanin A,Raddeanin R3

Target: Apoptosis, HDAC

Cat.No: T14305

Synonym: OSI 2040

Target: Apoptosis, HDAC, Autophagy

9-hydroxy Stearic Acid

Cat.No: T37067

Target: HDAC

Delphinidin chloride

Cat.No: TN1567

Target: Estrogen Receptor/ERR, VEGFR

L-2-Hydroxyglutaric acid

Cat.No: T13749

Synonym: (S)-2-Hydroxyglutaric acid

Target: Others

Cat.No: T70778

Cat.No: T75767

1-Alaninechlamydocin

Cat.No: T36797

16-Hydroxycleroda-3,13-dien-15,16-olide

Cat.No: TN2646

Target: Autophagy

4beta-Hydroxywithanolide E

Cat.No: TN3070

Target: PARP, HSP, NF-κB, COX

Nε,Nε,Nε-Trimethyllysine chloride

Cat.No: T5066

Synonym: Lys(Me)3-OH Chloride,Nε,Nε,Nε-Trimethyllysine hydrochloride

Target: Others, Endogenous Metabolite

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