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Search Results for " anticonvulsant "

179

抑制剂 & 化合物

30

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T73586	Anticonvulsant agent 2	Others	Others
	Anticonvulsant agent 2 是一种有效的口服活性抗惊厥剂，在耐药性癫痫模型中显示出抗癫痫活性。
T10027	Anticonvulsant agent 1 4-(2,2-Difluoroethenyl)-α-ethyl-2-oxo-1-pyrrolidineacetamide	Others	Others
	Anticonvulsant agent 1 is an anticonvulsant compound.
T3563	Lvguidingan	Others	Others
	Lvguidingan 是一种抗惊厥药。
T8588	Buramate	Antibacterial	Microbiology/Virology
	Buramate 是抗精神病药和抗惊厥药。
T15545	ICA-27243	Potassium Channel	Membrane transporter/Ion channel
	ICA-27243 是选择性的，口服有效的 KCNQ2/Q3钾通道开放剂，EC50为 0.38 μM。对 KCNQ4 和 KCNQ3/Q5 的激活效果较差。它具有抗惊厥和抗癫痫作用。
T6259	Dizocilpine 地佐环平,MK-801	NMDAR; iGluR	Membrane transporter/Ion channel; Neuroscience
	Dizocilpine (MK-801) 是一种选择性非竞争性NMDA 受体拮抗剂，Kd=37.2 nM，是一种抗惊厥剂。它通过与 NMDA 相关离子通道内的一个位点结合而起作用，从而阻止 Ca2+的流动。
T0413	Cinromide 醒隆酰胺,trans-3-Bromo-N-ethylcinnamamide	Others	Others
	Cinromide (trans-3-Bromo-N-ethylcinnamamide) 是抗惊厥药，能够抑制上皮中性氨基酸转运蛋白 B0AT1 (SLC6A19)，其 IC50=0.5 μM。
T0600	10,11-Dihydrocarbamazepine 双氢卡马西平,10,11-二氢卡马西平,Dihydrocarbamazepine	Others	Others
	10,11-Dihydrocarbamazepine (Dihydrocarbamazepine) 是一种 Oxcarbazepine 的活性代谢物，也是一种有机中间体。Oxcarbazepine 能够几乎完全的、迅速的转化为 10,11-Dihydrocarbamazepine，可能具有抗惊厥效果。
T7780	Blarcamesine AE-37,AVex-73	AChR	Neuroscience
	Blarcamesine (AVex-73) 是一种毒蕈碱 M1 激动剂，具有抗惊厥、抗失忆、神经保护和抗抑郁的特性，可能用于治疗阿尔茨海默病。
T0440	Oxcarbazepine GP 47680,奥卡西平	Apoptosis; Sodium Channel	Apoptosis; Membrane transporter/Ion channel
	Oxcarbazepine (GP 47680) 是一种钠通道阻滞剂，有效抑制胶质母细胞瘤细胞生长并诱导胶质母细胞瘤细胞凋亡或 G2/M 停滞，具有抗癌和抗惊厥作用。
T4118	SB 271046 hydrochloride SB 271046A	5-HT Receptor	GPCR/G Protein; Neuroscience
	SB 271046 hydrochloride (SB 271046A) 是高效、选择性和具有口服活性的5-HT6受体拮抗剂，对大鼠、猪和人的pKi 分别为 9.02、8.55 和 8.81。它增加额叶皮层中的细胞外天冬氨酸和谷氨酸并表现出抗惊厥活性，EC50为 0.16 μM。它对 5-HT6 受体、结合位点和离子通道的选择性超过 200 倍。
T22675	Co 102862 V 102862	Others; Sodium Channel	Membrane transporter/Ion channel; Others
	Co 102862 是一种电压门控钠通道阻滞剂。 Co 102862 可用于抗惊厥的研究。
T0283	Trimethadione 三甲双酮,3,5,5,-Trimethyloxazolidine-2,4-dione	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Trimethadione (3,5,5,-Trimethyloxazolidine-2,4-dione) 是恶唑烷二酮类抗惊厥剂，也是一种 T 型钙通道阻滞剂，具有抗痛觉过敏作用，可用于研究失神发作。
TP2036L	DPDPE TFA (88373-73-3 free base) DPDPE TFA	Opioid Receptor	Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	DPDPE TFA 是选择性 δ-阿片受体激动剂肽，在体内具有镇痛作用。
T0992	Carbenoxolone disodium Biogastrone,Duogastrone,甘珀酸钠,Bioral	Gap Junction Protein	Cytoskeletal Signaling
	Carbenoxolone disodium (Duogastrone) 是甘草酸的活性代谢物和人11β-HSD 和细菌3α, 20β-HSD 的抑制剂。它是一种缝隙连接的解耦剂，可抑制牛痘病毒生长，用于消化性、食道和口腔溃疡和炎症的相关研究。
T14983	Clomethiazole Distraneurin,Chlormethiazole,氯美噻唑,5-(2-CHLOROETHYL)-4-METHYLTHIAZOLE	P450; GABA Receptor	Membrane transporter/Ion channel; Metabolism; Neuroscience
	Clomethiazole (Distraneurin) 是口服GABAA 激动剂，可抑制人肝微粒体中的细胞色素 P450 异构体，CYP2A6 和 CYP2E1。它有抗惊厥作用，具有治疗惊厥性癫痫持续状态的潜力。
TP2036	DPDPE	Opioid Receptor	Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	DPDPE 是选择性 δ-阿片受体激动剂肽，在体内具有镇痛作用。
T2535	Ivabradine hydrochloride 盐酸伊伐布雷定,S 16257-2,Ivabradine HCl	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Ivabradine hydrochloride (S 16257-2) 是一种可口服的，超极化激活的环核苷酸门控离子通道通道阻滞剂。
T21029	Norfluoxetine Hydrochloride Norfluoxetine HCl,去甲氟西汀	Others	Others
	Norfluoxetine Hydrochloride (Norfluoxetine HCl) 是氟西汀的活性代谢物。氟西汀是一种抗抑郁药。
T7806	Licarbazepine 10,11-hydroxy-10,11 Dihydrocarbamezer,10,11-二氢-10-羟基卡马西平	Others	Others
	Licarbazepine (10,11-hydroxy-10,11 Dihydrocarbamezer) 是一种有效的电压门控钠通道阻滞剂，具有抗惊厥和稳定情绪的功效。
T1602	Valproic acid sodium salt 丙戊酸钠,Sodium Valproate	Mitophagy; Gamma-secretase; HIV Protease; GABA Receptor; HDAC; Autophagy	Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience; Proteases/Proteasome; Stem Cells
	Valproic acid sodium salt (Sodium Valproate) 是一种HDAC 抑制剂，可抑制HDAC1的活性，诱导HDAC2的降解。它激活Notch1信号并抑制小细胞肺癌细胞的增殖。它可研究癫痫、偏头痛和双相情感障碍等。
T8456	GALNON	Neuropeptide Y Receptor	GPCR/G Protein; Neuroscience
	Galnon 是一种甘丙肽受体激动剂，可改善内在的皮质骨组织特性。
T6474	Divalproex Sodium Valproate semisodium,Epival,双丙戊酸钠	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Divalproex Sodium (Valproate semisodium) 结合并抑制 γ-氨基丁酸 (GABA) 转氨酶，其抗惊厥活性可通过增加 GABA 脑浓度和抑制分解 GABA 或阻止 GABA 再摄取到神经胶质和神经末梢的酶来发挥。它也是一种 HDAC 抑制剂。由丙戊酸钠和丙戊酸组成，具有抗惊厥和抗癫痫活性。 Divalproex 还可以通过抑制电压敏感的钠通道来抑制重复的神经元放电。
T8435	YM90K YM90K hydrochloride,6-(1H-imidazol-1-yl)-7-nitro-2,3(1H,4H)-,1,4-二氢-6-(1H-咪唑-1-基)-7-硝基-2,3-喹喔啉二酮单盐酸盐	GluR; iGluR	Membrane transporter/Ion channel; Neuroscience
	YM90K (6-(1H-imidazol-1-yl)-7-nitro-2,3(1H,4H)-) hydrochloride 是一种选择性的、有效的AMPA 受体拮抗剂，Ki=84 nM。YM90K 抑制海藻酸酯 (Ki 为 2.2 μM) 和 NMDA (Ki 为 37 μM) 受体的效力较低，并具有神经保护活性。
T6651	Safinamide mesylate PNU-151774E,FCE28073,PNU-151774E,NW-1015,EMD 1195686 mesylate,沙芬酰胺甲磺酸盐	MAO; Monoamine Oxidase	Metabolism; Neuroscience
	Safinamide mesylate (EMD 1195686 mesylate) 是选择性的、有效的、可逆的单胺氧化酶 B 的抑制剂，对 MAO-A 选择性较低。它能够阻断钠通道和调节谷氨酸释放。它具有神经保护作用，可用于研究帕金森病、缺血脑卒中等疾病。
T3320	Dizocilpine Maleate (+)-Mk-801 Hydrogen Maleate,MK 801,地卓亚平马来酸盐,Dizocilpine hydrogen maleate,地佐环平马来酸盐,(+)-MK 801 maleate,(+)-MK 801 (Maleate)	NMDAR; iGluR	Membrane transporter/Ion channel; Neuroscience
	Dizocilpine Maleate (MK 801) 是一种选择性和非竞争性的 NMDA 受体拮抗剂，Kd 值为 37.2 nM。它用于治疗 NMDA 受体可能发挥重要作用的多种神经退行性疾病或疾病。
T1249	Beclamide N-Benzyl-3-chloropropionamide,Chloracon,Chlorakon,贝克拉胺(INN)	Others	Others
	Beclamide (Chlorakon) 是一种抗惊厥药，具有抗惊厥作用。
T28503	Ralitoline GOE-4942,PD-117818,Ralitolina,CI-946,Ralitolinum
	Ralitoline (Ralitolinum) 是一种抗惊厥剂，具有抗癌活性和钠通道阻断活性。
T14863	Carabersat SB 204269	Others	Others
	Carabersat （SB 204269）是一种新型有效的抗惊厥和抗癫痫试剂。
T40709	3-Diethylamino-1-propanol	Others	Others
	3-Diethylamino-1-propanol 具有抗惊厥作用。
T10774	CFM-2	iGluR	Membrane transporter/Ion channel; Neuroscience
	CFM-2, a potent and selective non-competitive antagonist of AMPAR (AMPAR), exhibits anticonvulsant activity across various seizure models.
T31614	Elpetrigine GW-273293,JZP 4,JZP4,GW273293,JZP-4,GW 273293
	Elpetrigine( GW 273293, JZP-4) is effective calcium and sodium channel blocker and is currently being evaluated in patients as an anticonvulsant and mood stabilizer.
T3562	Valrocemide TV1901,N-丙戊酰基甘氨酰胺,N-Valproylglycinamide,丙戊塞胺	Others	Others
	Valrocemide (TV1901) 是有前景的抗癫痫候选药物，具有广泛的抗惊厥特性。
T5517	(R)-Carisbamate	Others	Others
	(R)-Carisbamate 是 Carisbamate 的 R-异构体。 Carisbamate 是一种实验性抗惊厥药。
T15302	Fluzinamide AHR-8559	Others	Others
	Fluzinamide（AHR-8559）对点燃性杏仁核癫痫发作有抗惊厥作用。
T8604	Fenaclon Fenaclonum	Others	Others
	Fenaclon (Fenaclonum) 是一种抗惊厥药。它适用于治疗癫痫。
T6744	Methylbenactyzium Bromide Noinarin,Paragone,Methylbenactyzine Bromide,溴甲贝那替秦,Semulgin,Gastrimade	AChR	Neuroscience
	Methylbenactyzium Bromide (Semulgin) 是毒蕈碱性乙酰胆碱受体抑制剂，是一种抗惊厥药。
T36839	(R)-Mephenytoin R-Mephenytoin,(R)-Mephenytoin,(–)-Mephenytoin	Others	Others
	(R)-Mephenytoin ((–)-Mephenytoin) 是 Mephenytoin 的 R-对映体，Mephenytoin 是一种抗惊厥药。
T10796	Chlormethiazole hydrochloride 氯美噻唑盐酸盐,Clomethiazole hydrochloride	Others	Others
	Chlormethiazole hydrochloride 是抗惊厥药。它具有神经保护作用，能够阻碍 MDMA 诱导的血清素能神经末梢退化。
T11349	GABAA receptor agent 1	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	GABAA receptor agent 1 是GABAA 受体的高亲和力配体，有抗惊厥活性。
T27047	Clovoxamine fumarate DU23811 fumarate,DU 23811 fumarate,DU-23811 fumarate	5-HT Receptor; Serotonin Transporter; Norepinephrine	GPCR/G Protein; Neuroscience
	Clovoxamine fumarate (DU 23811 fumarate) 是一种 5-羟色胺再摄取、血清素和去甲肾上腺素抑制剂，具有抗抑郁和抗惊厥活性。
T21425	Mephenytoin Mesantoin,Methoin,Insulton,Phenantoin,美芬妥因,Methylphenetoin	P450	Metabolism
	Mephenytoin (Phenantoin) 是 CYP2C19 及 CYP2B6 的底物，是一种抗惊厥剂。
T4688	Pipequaline hydrochloride PK-8165 hydrochloride,盐酸哌夸林	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	Pipequaline hydrochloride (PK-8165 hydrochloride) 是一种苯二氮卓受体部分激动剂，有抗焦虑作用。
T11278	FG8119 NNC13-8119	Others	Others
	FG8119 是一种新型苯二氮卓 (benzodiazepine) 激动剂，具有潜在的抗惊厥和抗癫痫活性，可用于研究神经系统疾病。
T14974	Citenamide Cytenamide,AY-15613	Others	Others
	Citenamide (AY-15613) 具有抗癌和抗惊厥活性，具有促进睡眠的作用，可用于研究神经系统疾病。
T7843	4-phenoxypiperidine	Others	Others
	4-phenoxypiperidine 具有肌肉松弛和抗惊厥活性。
T8594	Pheneturide 2-PHENYLBUTYRYLUREA,S-46,Benuride,苯丁酰脲	Others	Others
	Pheneturide (Benuride) 是Phenobarbita l 脱羧后的产物，可阻止精神运动性癫痫发作。
T27288	Esuprone LU-43839,LU 43839,LU43839	MAO	Metabolism; Neuroscience
	Esuprone (LU-43839) 是一种新型可逆且具有高选择性的MAO-A 抑制剂，具有抗惊厥活性，可用于治疗抑郁症。
T31354	Decimemide V 285,V-285,V285	Others	Others
	Decimemide (V-285)是一种烷氧基苯甲酸衍生物，具有抗癫痫活性和潜在的抗惊厥活性，可用研究神经系统疾病。
T1860	Imepitoin AWD 131-138,ELB-138,伊匹妥英	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	Imepitoin (AWD 131-138) 是一种新型的低亲和力部分苯二氮卓受体激动剂，有抗惊厥和抗焦虑作用。

化合物

Anticonvulsant agent 2

Cat.No: T73586

Target: Others

Anticonvulsant agent 1

Cat.No: T10027

Synonym: 4-(2,2-Difluoroethenyl)-α-ethyl-2-oxo-1-pyrrolidineacetamide

Target: Others

Cat.No: T3563

Target: Others

Cat.No: T8588

Target: Antibacterial

Cat.No: T15545

Target: Potassium Channel

Cat.No: T6259

Synonym: 地佐环平,MK-801

Target: NMDAR, iGluR

Cat.No: T0413

Synonym: 醒隆酰胺,trans-3-Bromo-N-ethylcinnamamide

Target: Others

10,11-Dihydrocarbamazepine

Cat.No: T0600

Synonym: 双氢卡马西平,10,11-二氢卡马西平,Dihydrocarbamazepine

Target: Others

Cat.No: T7780

Synonym: AE-37,AVex-73

Target: AChR

Cat.No: T0440

Synonym: GP 47680,奥卡西平

Target: Apoptosis, Sodium Channel

SB 271046 hydrochloride

Cat.No: T4118

Synonym: SB 271046A

Target: 5-HT Receptor

Cat.No: T22675

Synonym: V 102862

Target: Others, Sodium Channel

Cat.No: T0283

Synonym: 三甲双酮,3,5,5,-Trimethyloxazolidine-2,4-dione

Target: Calcium Channel

DPDPE TFA (88373-73-3 free base)

Cat.No: TP2036L

Synonym: DPDPE TFA

Target: Opioid Receptor

Carbenoxolone disodium

Cat.No: T0992

Synonym: Biogastrone,Duogastrone,甘珀酸钠,Bioral

Target: Gap Junction Protein

Cat.No: T14983

Synonym: Distraneurin,Chlormethiazole,氯美噻唑,5-(2-CHLOROETHYL)-4-METHYLTHIAZOLE

Target: P450, GABA Receptor

Cat.No: TP2036

Target: Opioid Receptor

Ivabradine hydrochloride

Cat.No: T2535

Synonym: 盐酸伊伐布雷定,S 16257-2,Ivabradine HCl

Target: Adrenergic Receptor

Norfluoxetine Hydrochloride

Cat.No: T21029

Synonym: Norfluoxetine HCl,去甲氟西汀

Target: Others

Cat.No: T7806

Synonym: 10,11-hydroxy-10,11 Dihydrocarbamezer,10,11-二氢-10-羟基卡马西平

Target: Others

Valproic acid sodium salt

Cat.No: T1602

Synonym: 丙戊酸钠,Sodium Valproate

Target: Mitophagy, Gamma-secretase, HIV Protease, GABA Receptor, HDAC, Autophagy

Cat.No: T8456

Target: Neuropeptide Y Receptor

Divalproex Sodium

Cat.No: T6474

Synonym: Valproate semisodium,Epival,双丙戊酸钠

Target: HDAC

Cat.No: T8435

Synonym: YM90K hydrochloride,6-(1H-imidazol-1-yl)-7-nitro-2,3(1H,4H)-,1,4-二氢-6-(1H-咪唑-1-基)-7-硝基-2,3-喹喔啉二酮单盐酸盐

Target: GluR, iGluR

Safinamide mesylate

Cat.No: T6651

Synonym: PNU-151774E,FCE28073,PNU-151774E,NW-1015,EMD 1195686 mesylate,沙芬酰胺甲磺酸盐

Target: MAO, Monoamine Oxidase

Dizocilpine Maleate

Cat.No: T3320

Synonym: (+)-Mk-801 Hydrogen Maleate,MK 801,地卓亚平马来酸盐,Dizocilpine hydrogen maleate,地佐环平马来酸盐,(+)-MK 801 maleate,(+)-MK 801 (Maleate)

Target: NMDAR, iGluR

Cat.No: T1249

Synonym: N-Benzyl-3-chloropropionamide,Chloracon,Chlorakon,贝克拉胺(INN)

Target: Others

Cat.No: T28503

Synonym: GOE-4942,PD-117818,Ralitolina,CI-946,Ralitolinum

Cat.No: T14863

Synonym: SB 204269

Target: Others

3-Diethylamino-1-propanol

Cat.No: T40709

Target: Others

Cat.No: T10774

Target: iGluR

Cat.No: T31614

Synonym: GW-273293,JZP 4,JZP4,GW273293,JZP-4,GW 273293

Cat.No: T3562

Synonym: TV1901,N-丙戊酰基甘氨酰胺,N-Valproylglycinamide,丙戊塞胺

Target: Others

(R)-Carisbamate

Cat.No: T5517

Target: Others

Cat.No: T15302

Synonym: AHR-8559

Target: Others

Cat.No: T8604

Synonym: Fenaclonum

Target: Others

Methylbenactyzium Bromide

Cat.No: T6744

Synonym: Noinarin,Paragone,Methylbenactyzine Bromide,溴甲贝那替秦,Semulgin,Gastrimade

Target: AChR

(R)-Mephenytoin

Cat.No: T36839

Synonym: R-Mephenytoin,(R)-Mephenytoin,(–)-Mephenytoin

Target: Others

Chlormethiazole hydrochloride

Cat.No: T10796

Synonym: 氯美噻唑盐酸盐,Clomethiazole hydrochloride

Target: Others

GABAA receptor agent 1

Cat.No: T11349

Target: GABA Receptor

Clovoxamine fumarate

Cat.No: T27047

Synonym: DU23811 fumarate,DU 23811 fumarate,DU-23811 fumarate

Target: 5-HT Receptor, Serotonin Transporter, Norepinephrine

Cat.No: T21425

Synonym: Mesantoin,Methoin,Insulton,Phenantoin,美芬妥因,Methylphenetoin

Target: P450

Pipequaline hydrochloride

Cat.No: T4688

Synonym: PK-8165 hydrochloride,盐酸哌夸林

Target: GABA Receptor

Cat.No: T11278

Synonym: NNC13-8119

Target: Others

Cat.No: T14974

Synonym: Cytenamide,AY-15613

Target: Others

4-phenoxypiperidine

Cat.No: T7843

Target: Others

Cat.No: T8594

Synonym: 2-PHENYLBUTYRYLUREA,S-46,Benuride,苯丁酰脲

Target: Others

Cat.No: T27288

Synonym: LU-43839,LU 43839,LU43839

Target: MAO

Cat.No: T31354

Synonym: V 285,V-285,V285

Target: Others

Cat.No: T1860

Synonym: AWD 131-138,ELB-138,伊匹妥英

Target: GABA Receptor

Cat. No.	Product Name	Target	Signaling Pathways
T5563	Cyclohexanecarboxylic Acid 环己甲酸,环己烷羧酸	Others; Endogenous Metabolite	Metabolism; Others
	Cyclohexanecarboxylic acid 是 Valproate 结构类似物，具有抗惊厥的作用。
T8014	Epoxylinalool 氧化芳樟醇,2-(2-Hydroxy-2-Propyl)-5-Methyl-5-Vinyltetrahydrofuran	Others	Others
	Epoxylinalool (2-(2-Hydroxy-2-Propyl)-5-Methyl-5-Vinyltetrahydrofuran) 是一种天然存在的单萜醇，广泛用于香水和调味品的生产。
T3248	alpha-Boswellic acid α-Boswellic acid,α-乳香酸	Others	Others
	alpha-Boswellic acid (α-Boswellic acid) 是一种从乳香中提取得到的五环三萜类天然产物，具有抗惊厥和抗癌作用。在动物体内，它是预防和减少阿尔茨海默病标志物，可用于阿尔茨海默病的研究。
T7064	Valproic Acid Sodium valproate,2-Propylpentanoic Acid,丙戊酸,VPA,Depakine,2-Propylvaleric Acid	Mitophagy; Gamma-secretase; HIV Protease; GABA Receptor; Sodium Channel; HDAC; Autophagy	Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience; Proteases/Proteasome; Stem Cells
	Valproic Acid (2-Propylpentanoic Acid) 是一种 HDAC 抑制剂，可抑制 HDAC1 活性，诱导 HDAC2 降解，具有口服活性。Valproic Acid 可以用于癫痫和躁郁症的研究。
TN2865	(E)-3,4,5-Trimethoxycinnamic acid O-Methylsinapic acid,3,4,5-三甲氧基肉桂酸,3,4,5-Trimethoxy-trans-cinnamic acid,3,4,5-Trimethoxyphenylacrylic acid	Others	Others
	(E)-3,4,5-Trimethoxycinnamic acid (O-Methylsinapic acid) 是一种来自羌活根和根茎的天然产物。
T65135	Kynurenic acid Fibrostop 2,Quinurenic acid	GPR; GluR; NMDAR	Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	Kynurenic acid (Quinurenic acid) 是一种内源性色氨酸活性代谢物，是一种 NMDA, glutamate, α7 nicotinic acetylcholine receptor 三重拮抗剂，也是 GPR35/CXCR8 激动剂，具有神经保护和抗惊厥特性，可用于研究神经分裂和与代谢相关的疾病。
TN4114	Gardenin A	ERK; LDL; MAPK; PKA; PKC	Chromatin/Epigenetic; Cytoskeletal Signaling; MAPK; Metabolism; Tyrosine Kinase/Adaptors
	Gardenin A 通过激活 MAPK/ERK、PKC 和 PKA 表现出神经营养作用。 Gardenin A 具有抗抑郁、抗惊厥和抗焦虑作用。
T20587	2-Acetonaphthone 2-萘乙酮,beta-Acetylnaphthalene,beta-Acetonaphthalene,2Acetylnaphthalene,2-Acetylnaphthalene,2 Acetylnaphthalene,beta-Naphthyl methyl ketone	Endogenous Metabolite	Metabolism
	2-Acetonaphthone (beta-Naphthyl methyl ketone) 是内源性代谢产物的一种。
T0728	Ethosuximide Zarontin,乙琥胺	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Ethosuximide (Zarontin) 是一种抗癫痫药物，可改善多种神经退行性疾病模型的表型，且阻断低电压激活的 T 型钙通道。
T0361	Isovaleramide 异戊酰胺,3-Methylbutanamide	Dehydrogenase	Metabolism
	Isovaleramide (3-Methylbutanamide) 是抗惊厥剂，能够调节中枢神经系统的活性。
T2S1814	p-Hydroxybenzaldehyde 4-Formylphenol,4-羟基苯甲醛;对羟基苯甲醛,4-hydroxybenzaldehyde,对羟基苯甲醛,p-Oxybenzaldehyde	Transaminase; GABA Receptor; Endogenous Metabolite	Membrane transporter/Ion channel; Metabolism; Neuroscience
	p-Hydroxybenzaldehyde (p-Oxybenzaldehyde) 是从天麻中提取的一种天然产物，对 GABA 转氨酶有抑制作用，有助于抗癫痫和抗惊厥活性。
T4842	1H-pyrazole 1,2-Diazole,Pyrazole,吡唑	Others; Endogenous Metabolite	Metabolism; Others
	1H-pyrazole (1,2-Diazole) 是内源性代谢产物的一种。
T5266	Tricaprilin Glycerol Tri-n-octanoate,三辛酸甘油酯,trioctanoin,tricaprylic glyceride,Glyceryl trioctanoate	Others; Endogenous Metabolite	Metabolism; Others
	Tricaprilin (Glycerol Tri-n-octanoate) 能够用于研究轻度到中度阿尔茨海默病患者，具有抗惊厥和植物代谢产物的活性。
TN7252	Olivetolic acid 2,4-Dihydroxy-6-pentylbenzoic acid	Antibiotic	Microbiology/Virology
	Olivetolic acid (OLA) 是一种来自大麻中大麻素的前体，在Dravet综合征的小鼠模型中显示抗惊厥活性。Olivetolic acid 具有潜在的抗菌活性。
TN5131	Tetrahydrocannabivarin THCV,delta9-Tetrahydrocannabivarin,CRM,Tetrahydrocannavarin	Cannabinoid Receptor	GPCR/G Protein
	Tetrahydrocannabivarin (CRM) 是 cannabinoid type 1 receptor 的中性拮抗剂，对 2 型糖尿病有潜在治疗价值。
T3836	Eudesmin	MAPK; S6 Kinase	MAPK; PI3K/Akt/mTOR signaling
	Eudesmin 通过抑制S6K1信号通路来干扰成脂分化，具有抗肿瘤、抗炎和抗菌活性。
Fr14115	α-Terpineol Terpineol,α-松油醇	IL Receptor; Anti-infection; Antibacterial	Immunology/Inflammation; Microbiology/Virology
	α-Terpineol (Terpineol) 是从蓝桉中分离出来的，对须癣毛癣菌有抗真菌活性，对牙周病和致龋菌有抗菌活性。它还具有抗惊厥和抗炎活性。
TMO2713	4(3H)-Quinazolinone Quinazolin-4-ol,4-Hydroxyquinazoline,4-羟基喹唑啉,4-Quinazolinol,4-Quinazolone,4-Quinazolinone	Antibacterial; Platelet aggregation	Microbiology/Virology; Others
	4(3H)-Quinazolinone (4-Hydroxyquinazoline) 是化学合成中的砌块，是一种生物活性氮杂环化合物。它具有多种生物学特性，如抗菌，抗真菌，抗惊厥，抗炎，抗 HIV，抗癌和缓解疼痛活性。
T5758	sphondin 6-甲氧基当归素,牛防风素,牛防风素	COX; Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Sphondin 具有抗惊厥、抗炎和抗增殖活性，对 IL-1beta 诱导的 A549 细胞中 COX-2 蛋白水平和 PGE(2) 释放的增加具有抑制作用。
T0883	Tramiprosate Homotaurine,3-Amino-1-propanesulfonic acid,Alzhemed,高牛黄酸	Beta Amyloid; GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	Tramiprosate (Alzhemed) 是一种具有口服活性的、可透过血脑屏障的天然氨基酸，存在于各种红色海藻中，能够可溶性 Aβ 结合并以非原纤维形式维持 Aβ。它是一种 GABA 类似物，具有神经保护，抗惊厥和抗高血压的活性。
T5566	Ethyl maltol 2-Ethyl-3-hydroxy-4H-pyran-4-one,乙基麦芽酚,2-Ethyl pyromeconic acid	Others	Others
	Ethyl maltol (2-Ethyl-3-hydroxy-4H-pyran-4-one) 是一种化合物，在食品添加剂中占有重要地位，主要作用于增强食品的香气，具备显著的气味活性。
TN1712	Gossypin	NF-κB; S6 Kinase	MAPK; NF-κB; PI3K/Akt/mTOR signaling
	Gossypin 是一种从Hibiscus vitifolius 中分离得到的黄酮，能够抑制NF-κB 和 NF-κB 的调节基因表达。在小鼠原代骨髓细胞和 RAW264.7 细胞中，它也可抑制 RANKL 诱导的破骨细胞形成。它具有抗氧化、抗炎、抗癌、抗衰老、抗糖尿病和保护肝脏的活性。
T5739	Paederosidic acid 鸡屎藤苷酸,异戊二酸紫草酸	Apoptosis; BCL	Apoptosis
	Paederosidic acid 是从鸡矢藤分离出的一种天然产物，通过诱导线粒体介导的凋亡抑制肺癌细胞，具有显着的抗肿瘤、抗惊厥和镇静作用。
T6S1653	Albiflorin Alibiflorin,芍药内酯苷	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	Albiflorin (Alibiflorin) 是一种牡丹根中的主要成分，是一种单萜糖苷。它具有神经保护、抗炎、抗氧化和缓解疼痛作用。
T37491	11-Oxo etiocholanolone
	11-Ketoetiocholanolone is a metabolite of testosterone's excreted metabolite, etiocholanolone, and exhibits anticonvulsant activity[1][2].
T12373	Paxilline	Others	Others
	Paxilline is an indole alkaloid mycotoxin from Penicillium paxilli, acts as a potent BK channels inhibitor by an almost exclusively closed-channel block mechanism. Paxilline possesses significant anticonvulsant activity.
T11534	Haemanthamine	Others	Others
	Haemanthamine is an alkaloid isolated from the Amaryllidaceae plants with potent anticancer activity. It inhibits protein biosynthesis during the elongation stage of translation. It has antimalarial, pro-apoptotic, antiviral, antioxidant, and anticonvulsa
TN4322	Isopulegol	ATPase; Potassium Channel; GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	Isopulegol presents depressant- and anxiolytic-like effects, it also has anticonvulsant and bioprotective effects against PTZ-induced convulsions are possibly related to positive modulation of benzodiazepine-sensitive GABAA receptors and to antioxidant properties.Isopulegol presents significant gastroprotective effects in both ethanol- and indomethacin-induced ulcer models, which appear to be mediated, at least in part, by endogenous prostaglandins, K(ATP) channel opening, and antioxidant proper...
TN4624	Nantenine	Others	Others
	Nantenine is an acetylcholinesterase inhibitor, it functions as an effective antagonist against a wide range of MDMA-induced effects in mice. Nantenine has anticonvulsant effect, which seems attributable to its stimulation and the resultant decrease of Ca
T73813	Haemanthamine hydrochloride
	Haemanthamine hydrochloride 是从Amaryllidaceae 植物中分离出来的一种蛇毒碱样生物碱，具有强大的抗癌活性。Haemanthamine hydrochloride 靶向核糖体以在翻译的延长阶段抑制蛋白质的生物合成。Haemanthamine hydrochloride 具有促凋亡，抗氧化剂，抗病毒，抗疟疾和抗惊厥活性。

天然产物

Cyclohexanecarboxylic Acid

Cat.No: T5563

Synonym: 环己甲酸,环己烷羧酸

Target: Others, Endogenous Metabolite

Cat.No: T8014

Synonym: 氧化芳樟醇,2-(2-Hydroxy-2-Propyl)-5-Methyl-5-Vinyltetrahydrofuran

Target: Others

alpha-Boswellic acid

Cat.No: T3248

Synonym: α-Boswellic acid,α-乳香酸

Target: Others

Cat.No: T7064

Synonym: Sodium valproate,2-Propylpentanoic Acid,丙戊酸,VPA,Depakine,2-Propylvaleric Acid

Target: Mitophagy, Gamma-secretase, HIV Protease, GABA Receptor, Sodium Channel, HDAC, Autophagy

(E)-3,4,5-Trimethoxycinnamic acid

Cat.No: TN2865

Synonym: O-Methylsinapic acid,3,4,5-三甲氧基肉桂酸,3,4,5-Trimethoxy-trans-cinnamic acid,3,4,5-Trimethoxyphenylacrylic acid

Target: Others

Cat.No: T65135

Synonym: Fibrostop 2,Quinurenic acid

Target: GPR, GluR, NMDAR

Cat.No: TN4114

Target: ERK, LDL, MAPK, PKA, PKC

2-Acetonaphthone

Cat.No: T20587

Synonym: 2-萘乙酮,beta-Acetylnaphthalene,beta-Acetonaphthalene,2Acetylnaphthalene,2-Acetylnaphthalene,2 Acetylnaphthalene,beta-Naphthyl methyl ketone

Target: Endogenous Metabolite

Cat.No: T0728

Synonym: Zarontin,乙琥胺

Target: Calcium Channel

Cat.No: T0361

Synonym: 异戊酰胺,3-Methylbutanamide

Target: Dehydrogenase

p-Hydroxybenzaldehyde

Cat.No: T2S1814

Synonym: 4-Formylphenol,4-羟基苯甲醛;对羟基苯甲醛,4-hydroxybenzaldehyde,对羟基苯甲醛,p-Oxybenzaldehyde

Target: Transaminase, GABA Receptor, Endogenous Metabolite

Cat.No: T4842

Synonym: 1,2-Diazole,Pyrazole,吡唑

Target: Others, Endogenous Metabolite

Cat.No: T5266

Synonym: Glycerol Tri-n-octanoate,三辛酸甘油酯,trioctanoin,tricaprylic glyceride,Glyceryl trioctanoate

Target: Others, Endogenous Metabolite

Olivetolic acid

Cat.No: TN7252

Synonym: 2,4-Dihydroxy-6-pentylbenzoic acid

Target: Antibiotic

Tetrahydrocannabivarin

Cat.No: TN5131

Synonym: THCV,delta9-Tetrahydrocannabivarin,CRM,Tetrahydrocannavarin

Target: Cannabinoid Receptor

Cat.No: T3836

Target: MAPK, S6 Kinase

Cat.No: Fr14115

Synonym: Terpineol,α-松油醇

Target: IL Receptor, Anti-infection, Antibacterial

4(3H)-Quinazolinone

Cat.No: TMO2713

Synonym: Quinazolin-4-ol,4-Hydroxyquinazoline,4-羟基喹唑啉,4-Quinazolinol,4-Quinazolone,4-Quinazolinone

Target: Antibacterial, Platelet aggregation

Cat.No: T5758

Synonym: 6-甲氧基当归素,牛防风素,牛防风素

Target: COX, Prostaglandin Receptor

Cat.No: T0883

Synonym: Homotaurine,3-Amino-1-propanesulfonic acid,Alzhemed,高牛黄酸

Target: Beta Amyloid, GABA Receptor

Cat.No: T5566

Synonym: 2-Ethyl-3-hydroxy-4H-pyran-4-one,乙基麦芽酚,2-Ethyl pyromeconic acid

Target: Others

Cat.No: TN1712

Target: NF-κB, S6 Kinase

Paederosidic acid

Cat.No: T5739

Synonym: 鸡屎藤苷酸,异戊二酸紫草酸

Target: Apoptosis, BCL

Cat.No: T6S1653

Synonym: Alibiflorin,芍药内酯苷

Target: Reactive Oxygen Species

11-Oxo etiocholanolone

Cat.No: T37491

Cat.No: T12373

Target: Others

Cat.No: T11534

Target: Others

Cat.No: TN4322

Target: ATPase, Potassium Channel, GABA Receptor

Cat.No: TN4624

Target: Others

Haemanthamine hydrochloride

Cat.No: T73813

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