307
210
1
16
Cat. No. | Product Name | ||
---|---|---|---|
L1200 | 表观遗传库 | 953 compounds | |
953 种表观遗传学研究相关的生物活性小分子的特有集合,用于表观遗传学研究及其相关的检测和高通量、高内涵筛选; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T6829 |
EPI-001
EPI001,EPI 001 |
Apoptosis; Androgen Receptor; PPAR | Apoptosis; DNA Damage/DNA Repair; Endocrinology/Hormones; Metabolism |
EPI-001 是一种选择性雄激素受体 (AR) 的抑制剂,靶向 AR 的反式激活单元 5,可抑制 AR 氨基末端结构域的反式激活,IC50值约为 6 μM。它也是一种选择性的PPARγ调节剂,对去势抵抗性前列腺癌具有活性。 | |||
T28502 |
Ralaniten
EPI-002 |
Androgen Receptor | Endocrinology/Hormones |
Ralaniten (EPI-002) 是一种具有有效性、特异性和口服活性的雄激素受体 N 端结构域 (AR-NTD) 拮抗剂。Ralaniten 对 AR 转录活性有抑制作用,IC50 值为 7.4 μM。Ralanites 具有抗癌活性,可用于研究去势抵抗性前列腺癌 (CRPC) 。 | |||
T60507 |
Utreloxastat
EPI 857,PTC857 |
Lipoxygenase | Metabolism |
Utreloxastat (PTC857) 是一种新型 15-脂氧合酶抑制剂,可用于研究肌萎缩侧索硬化症 。 | |||
T37970 |
12-epi Leukotriene B4
12-epi Leukotriene B4 |
||
Leukotriene B4 (LTB4) compounds are produced by both enzymatic and non-enzymatic processes. The products of enzymatic origin, via Leukotriene A4 (LTA4) hydrolase, are stereospecifically 12(R). Non-enzymatic hydrolysis products are 50:50 mixtures at C-12, but are almost exclusively trans at C-6. Thus, the non-enzymatic hydrolysis product of LTA4 is 6-trans-12-epi LTB4. 12-epi LTB4 is an isomer which would not be expected to occur in either non-enzymatic hydrolysis products, or in the enzymatic pr... | |||
T36375 |
Ralaniten triacetate
EPI-506 |
Androgen Receptor | Endocrinology/Hormones |
Ralaniten triacetate (EPI-506) 是 Ralaniten 的前体,是一种具有口服活性的雄激素受体 N 端结构域 (AR-NTD) 抑制剂,具有抗癌活性,可用于研究前列腺癌和乳腺癌。 | |||
T36919 |
1α-Hydroxy-3-epi-vitamin D3
1α-Hydroxy-3-epi-vitamin D3 |
||
1α-Hydroxy-3-epi-vitamin D3, a natural metabolite derived from 1alpha,25-dihydroxyvitamin D3, effectively suppresses parathyroid hormone (PTH) secretion[1]. | |||
TQ0247 |
7-Epi-docetaxel
7-Epidocetaxel,7-表多西他赛,4-epi-Docetaxel,7-Epitaxotere |
Others | Others |
7-Epi-10-oxo-docetaxel (7-Epitaxotere) is a impurity of docetaxel. | |||
T35500 |
3-epi-25-hydroxy Vitamin D3
3-epi-25-hydroxy Vitamin D3 |
||
3-epi-25-hydroxy Vitamin D3is the C-3 epimer of 25-hydroxy vitamin D3.1Dietary administration of 3-epi-25-hydroxy vitamin D3(0.5 and 1 IU/g) decreases levels of serum parathyroid hormone (PTH) in male, but not female, weanling rats. 1.Djekic-Ivankovic, M., Lavery, P., Agellon, S., et al.The C-3α epimer of 25-hydroxycholecalciferol from endogenous and exogenous sources supports normal growth and bone mineral density in weanling ratsJ. Nutr.147(2)141-151(2017) | |||
T11214 |
EPI-589
|
Others | Others |
EPI-589, a quinone derivative and oxidoreductase enzyme inhibitor, is considered safe and well tolerated, showing promise for the treatment of amyotrophic lateral sclerosis (ALS). | |||
T37001 |
7-epi Maresin 1
|
||
7-epi Maresin 1 is the inactive 7(S) epimer of Maresin 1 , which contains a 7(R) hydroxyl group. It can be used as an experimental negative control. | |||
T36595 |
4-epi-Chlortetracycline (hydrochloride)
|
||
Chlortetracycline is an analog of tetracycline , a broad spectrum antibiotic. In addition to its actions against microorganisms, chlortetracycline suppresses inflammation by inhibiting neutrophil action and other aspects of the innate immune response. 4-epi-Chlortetracycline is an epimer of chlortetracycline. | |||
T72726 |
3-epi-Vitamin D3
Epicholecalciferol |
||
3-epi-Vitamin D3 (Epicholecalciferol) 是维生素 D3 类似物,是一种Hedgehogpathway 抑制剂,在U87MG 细胞中测定的IC50为 39.2 μM。 | |||
T37396 |
13-epi-12-oxo Phytodienoic Acid
|
||
13-epi-12-oxo Phytodienoic acid (13-epi-12-oxo PDA) is a lipoxygenase metabolite of α-linolenic acid in the leaves of green plants such as corn. ω-3 and ω-6 polyunsaturated fatty acids in plants are substrates for plant lipoxygenases. 12-oxo PDA is one of the best studied end metabolites of this enzymatic pathway. While the initial enzymatic product and major isomer of 12-oxo PDA contains side chains in the cis position, both being β to the ring, the upper side chain attached at C-13, can and fr... | |||
T19163 |
7-Epi-10-oxo-docetaxel
Docetaxel Impurity 2 |
Others | Others |
7-Epi-10-oxo-docetaxel (Docetaxel Impurity 2) is an impurity of docetaxel detected by HPLC. | |||
T33536 |
Mycarose
3-Epi-axenose |
||
Mycarose is a sugar epi-axenose to lyxo configeration. | |||
T72998 |
L-Afegostat
5-epi-Isofagomine |
||
L-Afegostat (5-epi-Isofagomine) 是一种糖苷酶 (glycosidase)抑制剂。L-Afegostat 是一种亚糖,可用于碳水化合物的合成。L-Afegostat 对 β-葡萄糖苷酶具有抑制作用,Ki 值为 30 μM。 | |||
T126054 |
Epi-Cryptoacetalide
|
||
Epi-Cryptoacetalide 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T126054。 | |||
T35040 |
Vatiquinone
EPI-743,EPI743,alpha-Tocotrienol quinone. ATQ3,EPI 743 |
||
Vatiquinone, also known as EPI 743, is an orally bioavailable para-benzoquinone being developed for inherited mitochondrial diseases. The mechanism of action of EPI-743 involves augmenting the synthesis of glutathione, optimizing metabolic control, enhanc | |||
T63811 |
EPI-7170
|
||
EPI-7170 是一种 ralaniten 类似物,是雄激素受体 N 端结构域 (androgen receptor N-terminal structural domain) 的有效拮抗剂,能够阻断全长 AR (FL-AR) 和 AR 剪接变体 (AR-Vs) 的转录活性。 EPI-7170 对 enzalutamide 耐药的去势抵抗性前列腺癌 (CRPC) 表现出抗肿瘤活性。 | |||
T32848 |
Lokysterolamine B
N-Acetyl-4beta-hydroxy-epi-plakinamine A |
||
Lokysterolamine B is a steroidal alkaloid isolated from a sponge, Corticium sp. | |||
T125334 | 15-Epi-Danshenol-A | ||
15-Epi-Danshenol-A 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T125334。 | |||
T77294 |
1-epi-Regadenoson
|
||
1-epi-Regadenoson为Regadenoson的α异构体杂质,后者是具有高选择性的腺苷A2A受体(adenosine A2A receptor)拮抗剂。 | |||
T36164 |
8-iso Prostaglandin F3α
8-iso Prostaglandin F3α,8-epi PGF3α |
||
8-iso PGF3α is an isoprostane produced from the free-radical peroxidation of EPA. Little is known about the biological activity of 8-iso PGF3α. There is one report that it is inactive in a TP receptor mediated assay of human platelet shape change, where 8-iso PGF2α has an ED50 value of 1 uM. [1] | |||
T131516 | Isopropyl-epi-isoobacunoate | ||
Isopropyl-epi-isoobacunoate 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T131516。 | |||
T131585 |
7-Epi-paradisiol
|
||
7-Epi-paradisiol 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T131585。 | |||
T75496 | 19-epi-Scholaricine | ||
19-epi-Scholaricine为一种口服活性吲哚生物碱,具备下调胶原纤维表达和增加超氧化物歧化酶(SOD)活性的特性。 | |||
T83763 |
EPI-X4 TFA
Endogenous Peptide Inhibitor of CXCR4 |
||
EPI-X4是一种源于人血清白蛋白408-423氨基酸的内源性肽段,是趋化因子(C-X-C基序)受体4 (CXCR4)的拮抗剂。在0.8至1,000µM的浓度范围内,EPI-X4能抑制表达CXCR4的HEK293细胞中由趋化因子(C-X-C基序)配体12 (CXCL12)诱发的钙离子动员和受体内化。EPI-X4还能抑制CXCL12诱导的Jurkat T细胞和人类CD34+造血干细胞的迁移。体内实验中,EPI-X4(16µmol/kg)在急性过敏性气道高嗜酸性粒细胞疾病的小鼠模型中减少了Cxcr4依赖的炎症细胞气道浸润。慢性肾脏病患者尿液中EPI-X4的水平增高,并与肾小球滤过率(GFR)成反比。 | |||
T69093 |
Epirubicin
IMI-28,表柔比星,4-epi DX,4'-Epidoxorubicin,IMI 28,4-epidoxorubicin,epi DX,4-epiadriamycin |
||
Epirubicin (4'-Epidoxorubicin) 是阿霉素的半合成的 L-阿拉伯糖衍生物,能够抑制 Topoisomerase,起到抗肿瘤的作用。Epirubicin 抑制 DNA 和 RNA 合成。Epirubicin 是一种 Forkhead box 蛋白 p3 (Foxp3) 抑制剂,可抑制调节性 T 细胞活性。 | |||
T75535 |
5-epi-Arvestonate A
|
||
5-epi-Arvestonate A是一种从(Seriphidium transiliense)绢毛菊中提取的倍半萜化合物,能够通过激活(MITF)小眼相关转录因子和酪氨酸酶家族基因来促进黑色素的产生。此外,5-epi-Arvestonate A还能通过JAK/STAT信号通路,抑制永生化人角化细胞(HaCaT)中IFN-γ趋化因子的表达。 | |||
T73671 |
7β-Hydroxy-epi-androsterone
|
||
7β-Hydroxy-epi-androsterone (7β-Hydroxy-EpiA) 是一种与ERβ结合的内源性雄激素衍生物,具有抗炎和神经保护特性。该化合物来源于dehydroepiandrosterone。 | |||
T124591 |
3-Epi-alpha-amyrin
|
||
3-Epi-alpha-amyrin 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T124591,CAS号为 5937-48-4。 | |||
T124075 |
8-epi-Chlorajapolide F
|
||
8-epi-Chlorajapolide F 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T124075。 | |||
T124413 |
3-Epi-beta-amyrin
|
||
3-Epi-beta-amyrin 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T124413,CAS号为 6811-63-8。 | |||
T72144 |
6-trans-12-epi-Leukotriene B4
|
||
6-trans-12-epi-Leukotriene B4 是一种花生四烯酸代谢物,是一种有效的抗炎剂。 | |||
T124173 |
18-Beta-hydroxy-3-epi-alpha-yohimbine
|
||
18-Beta-hydroxy-3-epi-alpha-yohimbine 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T124173。 | |||
TNU0789 |
3-epi-Azido-3-deoxythymidine
|
||
3’-N-modified nucleoside; Azido-nucleoside | |||
T71606 | RO5073012 | ||
RO5073012 is a novel potent and selective TAAR1 partial agonist. | |||
T71046 |
FK-1052
|
||
FK-1052 is a serotonin 3 & 4 dual receptor antagonist. | |||
T0264 |
Zomepirac sodium salt
Zomepirac Sodium,佐美酸钠,McN-2783-21-98 |
PGE Synthase; PDE | Immunology/Inflammation; Metabolism |
Zomepirac sodium salt (McN-2783-21-98) 是前列腺素合成酶抑制剂。它是一种非甾体抗炎药,但能够导致免疫介导的肝损伤。 | |||
T50083 |
12-oxo-N-[1-(propan-2-yl)piperidin-4-yl]-6H,7H,8H,9H,10H,12H-azepino[2,1-b]quinazoline-3-carboxamide
|
Others | Others |
12-oxo-N-[1-(propan-2-yl)piperidin-4-yl]-6H,7H,8H,9H,10H,12H-azepino[2,1-b]quinazoline-3-carboxamide 可用作分子结构单元,用于多种化合物的合成。 | |||
T0946 |
Mepivacaine hydrochloride
Mepivacaine HCl,盐酸甲哌卡因 |
Sodium Channel | Membrane transporter/Ion channel |
Mepivacaine hydrochloride (Mepivacaine HCl) 是具有局部麻醉特性的酰胺衍生物。Mepivacaine hydrochloride 与神经元细胞膜上特定的电压门控钠离子通道结合,抑制钠离子内流和膜去极化。 | |||
T19917 |
Gepirone
|
5-HT Receptor | GPCR/G Protein; Neuroscience |
Gepirone 属于丁螺环酮家族的 5-HT1A 受体激动剂。它对 5-HT1A 受体的选择性高于 SSRIs。 | |||
T1743 |
Aprepitant
MK-869,MK-0869,阿瑞匹坦,L-754030,Aprepitant` |
HIV Protease; Antibacterial; Antibiotic; Neurokinin receptor | GPCR/G Protein; Microbiology/Virology; Neuroscience; Proteases/Proteasome |
Aprepitant (Aprepitant`) 是选择性和高亲和力的神经激肽1受体拮抗剂,Kd 值为86 pM。 | |||
T61934 |
Repinotan
BAY x 3702 free base |
5-HT Receptor | GPCR/G Protein; Neuroscience |
Repinotan (BAY x 3702 free base) 是一种可透过血脑屏障(BBB)且具有口服活性和选择的 5-HT1A 受体激动剂,具有神经保护活性,可拮抗吗啡诱导的麻醉大鼠通气抑制,可用于研究急性缺血性中风和创伤性脑损伤。 | |||
T0943 |
Carbamazepine
卡马西平,NSC 169864 |
Mitophagy; Sodium Channel; Autophagy | Autophagy; Membrane transporter/Ion channel |
Carbamazepine (NSC-169864) 是与三环抗抑郁药化学相关的三环化合物,具有抗惊厥和镇痛特性。它通过减少多突触反应和阻断强直后增强发挥其抗惊厥活性。 它通常用于治疗与三叉神经痛相关的疼痛。 | |||
T1540 |
Doxepin hydrochloride
Toruan,Doxepin HCl,Aponal,Novoxapin,盐酸多塞平 |
P450; Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor; AChR; Norepinephrine; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Metabolism; Neuroscience |
Doxepin hydrochloride (Aponal) 是一种可口服的三环抗抑郁剂,是选择性组胺受体 H1拮抗剂。它也是 CYP450抑制剂,抑制 CYP450 2C19和 CYP450 1A2。 | |||
T1542 |
Pirenzepine dihydrochloride
Pirenzepine HCl,Bisvanil,Tabe,盐酸哌仑西平,LS519 |
AChR | Neuroscience |
Pirenzepine dihydrochloride (LS519) 是一种选择性 M1 毒蕈碱受体拮抗剂,可抑制胃液分泌。 | |||
T50048 |
4,4-dimethyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-one
|
Others | Others |
4,4-dimethyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-one 是一种苯二氮卓类衍生物,GABAA 受体的正变构调节剂,选择性地与 GABAA 受体的苯二氮卓类位点结合,具有抗焦虑、抗惊厥和镇静的活性。 | |||
T21723L |
Epidermal Growth Factor Receptor Peptide Acetate
Epidermal Growth Factor Receptor Peptide Acetate(96249-43-3 Free base) |
Others | Others |
Epidermal Growth Factor Receptor Peptide Acetate (Epidermal Growth Factor Receptor Peptide Acetate (96249-43-3 Free base)) 存在于细胞表面,通过与其特异性配体的结合而被激活。EGFR 属于受体酪氨酸激酶(RTK) 的 ErbB 家族。 | |||
TP2189L |
V5 Epitope Tag Peptide acetate
|
Others | Others |
V5 Epitope Tag Peptide acetate 是一种肽 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3S2372 |
7-epi-Taxol
7-Epitaxol,7-表紫杉醇,7-epi-Paclitaxel |
Others; Microtubule Associated | Cytoskeletal Signaling; Others |
7-epi-Taxol (7-Epitaxol) 是在细胞中发现的紫杉醇的主要衍生物,在抑制细胞增殖、微管解离和诱导微管聚合等方面与紫杉醇作用相当。 | |||
T13681 |
Epi-galantamine
|
AChE | Neuroscience |
Epi-galantamine 是 Galantamine 的非对映异构体,是从高加索雪花莲的鳞茎和花朵中分离出来的生物碱。它能够抑制AChE,EC50=45.7 μM 。 | |||
T5738 |
7-Epi 10-desacetyl paclitaxel
10-Deacetyl-7-epipaclitaxel,7-Epi-10-deacetyltaxol,7-表-10-去乙酰基云南紫杉宁A |
Others | Others |
7-Epi 10-desacetyl paclitaxel (10-Deacetyl-7-epipaclitaxel) 是紫杉醇衍生物,对 HeLa 细胞具有细胞毒性(IC50:85 μM)。 | |||
TN2755 |
2-Desoxy-4-epi-pulchellin
|
Anti-infection | Microbiology/Virology |
2-Desoxy-4-epi-pulchellin 是分离自 Polygonum hydropiper 的二氯甲烷可溶部分的一种化合物。 | |||
T40200 |
5-epi-Jinkoheremol
|
||
5-epi-Jinkoheremol exhibits more potent fungicidal activity than validamycin. | |||
TN3962 |
epi-Eudesmol
|
Others | Others |
epi-Eudesmol is a natural product from Laggera alata var. montana C. D. Adams. | |||
TN2368 |
8-Epiloganic acid
8-表马钱子苷酸,8-Epi-Loganic acid |
Others | Others |
8-Epiloganic acid 是一种从 Linaria cymbalaria(玄参科) 中分离得到的环烯醚萜苷。 | |||
T19882 |
Bryonolic acid
UNII-J7YR6A878I,20-epi-Bryonolic acid |
Apoptosis; Antioxidant; Calcium Channel | Apoptosis; Membrane transporter/Ion channel; Metabolism; oxidation-reduction |
Bryonolic acid (20-epi-Bryonolic acid) 是一种从 Sandoricum indicum 提取的三萜类化合物,具有免疫调节、抗炎,抗氧化和抗癌等活性,通过抑制Ca2+内流和调节Ca2+-CaMKII-CREB信号通路中的基因表达来避免PC12细胞免受NMDA诱导的细胞凋亡反应。 | |||
TN3025 |
4-Epi-curcumenol
|
Others | Others |
4-Epi-curcumenol是一种天然产物,属于姜科姜黄属,其产品编号为 TN3025,CAS号为 350602-21-0。4-Epi-curcumenol可用作对照参考。 | |||
TN3163 | 6-epi-Albrassitriol | Others | Others |
6-epi-Albrassitriol is a natural product from A spergillussp. | |||
TN3026 |
4-Epi-isoinuviscolide
|
Others | Others |
4-Epi-isoinuviscolide是一种天然产物,属于菊科旋覆花属,其产品编号为 TN3026,CAS号为 68832-39-3。4-Epi-isoinuviscolide可用作对照参考。 | |||
TN6388 |
Methyl epi-dihydrophaseate
|
||
Methyl epi-dihydrophaseate 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN6388,CAS号为 57761-30-5。 | |||
TN1222 |
26-Deoxyactein
27-Deoxyactein,脱氧升麻烃,23-epi-26-Deoxyactein,27-脱氧升麻亭 |
NOS; CDK; NO Synthase | Cell Cycle/Checkpoint; Immunology/Inflammation |
23-epi-26-Deoxyactein (27-Deoxyactein) 是一种黑升麻中的主要成分,能够阻止 TCDD 诱导的成骨细胞的损伤。它对 AhR,CYP1A1 和 ERK 的水平升高具有抑制作用。 | |||
TN3164 |
6-epi-Augustifolin
|
Others | Others |
6-epi-Augustifolin 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN3164,CAS号为 369390-94-3。 | |||
TSP-40962761 |
3-epi Caryoptin
|
||
3-epi Caryoptin 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 TSP-40962761。 | |||
T39613 |
11-epi-mogroside V
|
||
11-epi-mogroside V, a compound found in the fruit of Siraitia grosvenori, possesses significant bioactivity by enhancing glucose uptake in vitro, specifically in human HepG2 cells. | |||
TN5605 |
7-Epi-10-deacetylcephalomannine
|
||
7-Epi-10-deacetylcephalomannine is a natural product from Taxus sumatrana. | |||
TN5972 |
3-epi-Isocucurbitacin B
|
||
3-epi-Isocucurbitacin B 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN5972,CAS号为 89647-62-1。 | |||
TN2756 | 2-Epi-3a-epiburchellin | Others | Others |
2-Epi-3a-epiburchellin 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN2756,CAS号为 57457-99-5。 | |||
TN3162 | 6-Epi-8-O-acetylharpagide | Others | Others |
6-Epi-8-O-acetylharpagide是一种天然产物,属于玄参科玄参属,其产品编号为 TN3162,CAS号为 97169-44-3。6-Epi-8-O-acetylharpagide可用作对照参考。 | |||
TN5394 |
3-epi-Dihydroscandenolide
15,6-diolide,3β-Acetoxy-1,10-epoxy-4-germacrene-12,8;15,6-diolide,3β-Acetoxy-1,10-epoxy-4-germacrene-12,8 |
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3-epi-Dihydroscandenolide 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN5394,CAS号为 1137951-08-6。 | |||
TN2597 |
12-Hydroxy-6-epi-albrassitriol
|
Others | Others |
12-Hydroxy-6-epi-albrassitriol 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN2597,CAS号为 178330-78-4。 | |||
TN3258 |
(7R)-Methoxy-8-epi-matairesinol
|
Others | Others |
(7R)-Methoxy-8-epi-matairesinol 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN3258,CAS号为 198827-23-5。 | |||
TN2895 |
3,5-Dicaffeoyl-epi-quinic acid
金银花 |
IL Receptor; p38 MAPK; TNF; Caspase; JNK; Histamine Receptor | Apoptosis; GPCR/G Protein; Immunology/Inflammation; MAPK; Neuroscience; Proteases/Proteasome |
3,5-Dicaffeoyl-epi-quinic acid shows anti-inflammatory activity, it may improve mast cell-mediated inflammatory diseases. | |||
T78480 |
24-Epicastasterone
24-epi-Castasterone |
||
24-Epicastasterone (24-epi-Castasterone) 是从 Hydrodictyon reticulatum 中提取的天然油菜素内酯类化合物。 | |||
T17198 |
UCN-02
7-epi-Hydroxystaurosporine |
Others | Others |
UCN-02 is a selective protein kinase C inhibitor produced by Streptomyces strain N-12 (IC50s: 62 nM and 250 nM for PKC and protein kinase A (PKA), respectively). | |||
TN3224 |
7-Epi-5-eudesmene-1beta,11-diol
|
Others | Others |
7-Epi-5-eudesmene-1beta,11-diol 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN3224,CAS号为 87261-77-6。 | |||
TN6799 |
Epiprogoitrin
表原告依春,epi-Progoitrin |
Others | Others |
Epiprogoitrin (epi-Progoitrin) 是一种硫代葡萄糖苷,来自于Crambe abyssinica 种子。 | |||
T74056 |
epi-Aszonalenin A
|
||
epi-Aszonalenin A 是一种苯二氮卓类真菌代谢物,从Aspergillus novofumigatus 中分离得到。epi-Aszonalenin A 可影响精神活动。 | |||
T83362 |
3-epi-Bufalin
|
||
3-epi-Bufalin (化合物2a) 是一种从蟾蜍二烯内酯通过微生物转化得到的产物。 | |||
T81701 |
Nardoguaianone K
10-epi-Nardoguaianone J |
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Nardoguaianone K,一种从Nardostachys chinensis根中分离得到的愈创木脂类化合物,用于胰腺癌研究。 | |||
TN6049 |
Rauvovertine A
2055073-71-5,17-epi-Rauvovertine A |
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Rauvovertine A shows cytotoxicity in vitro against human tumor cell lines. | |||
T83361 |
3-epi-Digitoxigenin
|
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3-epi-Digitoxigenin为三萜类化合物,源自鸡蛋花叶及茎部的提取物。 | |||
T83591 |
(±)-7-epi-Kadsurenone
|
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(±)-7-epi-Kadsurenone 是一种新型木脂素,具备氢苯并呋喃结构以及双环[3.2.1]辛烷骨架。 | |||
T83359 |
3-epi-Tilifodiolide
|
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3-epi-Tilifodiolide为一种与新氯烷有关的二萜类化合物,可从丹参(Salvia leucantha)地上部提取。 | |||
TN1614 |
Episyringaresinol
(+)-epi-syringaresinol,ZINC5665087,(+)-Lirioresinol A,表丁香脂素 |
Others | Others |
Episyringaresinol ((+)-epi-syringaresinol) 是一种从 Kalimeris indica 中分离出来的天然木脂素。 | |||
T83360 |
3-epi-Padmatin
|
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3-epi-Padmatin是从Inula graveolens中提取的一种天然产物。 | |||
T75609 | 7-epi-Isogarcinol | ||
7-epi-Isogarcinol 是一种PPAP(多环聚异戊二烯酰基间苯三酚),显示出适度的抗增殖活性。它通过阻断STAT3信号通路,诱导apoptosis(细胞凋亡)并抑制细胞迁移作用。 | |||
T83319 |
4-epi-Withaferin A
|
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4-epi-Withaferin A(化合物28)是Withaferin A的一个类似物,它增强了细胞毒性及细胞保护性热休克诱导活性(HSA)。此外,4-epi-Withaferin A还展现了通过激活细胞防御机制来研究蛋白质聚集相关疾病的潜力。 | |||
T75453 | 11-epi-Chaetomugilin I | ||
11-epi-Chaetomugilin I 是一种在Chaetomium globosum 中发现的代谢物。11-epi-Chaetomugilin I 对小鼠 P388 白血病细胞系、人类 HL-60 白血病细胞系、小鼠 L1210 白血病细胞系和人类 KB 表皮样癌细胞系具有显著的细胞毒性活性。 | |||
T74133 | 23-epi-26-Deoxyactein | ||
23-epi-26-Deoxyactein 是天然的、具有口服活性的抗肥胖和抗肿瘤作用的化合物。 | |||
T83397 |
23-Epi-26-deoxycimicifugoside
|
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23-Epi-26-deoxycimicifugoside是源自Cimicifuga racemosa的一种三萜木糖。 | |||
T19880 |
Friedelinol
Friedelan-3alpha-ol,Friedelan-3-ol,NSC 407041,epi-Friedelinol,Epifriedelanol |
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Friedelinol is a pentacyclic trierpene plant as the free acid or the aglycone for many saponins. Friedelinol can rearrange to the isomer, ursolic acid, or be oxidized to taraxasterol and amyrin. | |||
TN2461 |
Loganic acid 6′-O-β-D-glucoside
8-Epi-Loganic acid-6'-O-β-D-glucoside |
Others | Others |
Loganic acid 6′-O-β-D-glucoside (8-Epi-Loganic acid-6'-O-β-D-glucoside) 是 Cistanche deserticola 的天然产物,可抑制 LPS 诱导的 NO 和 TNF-α 的产生。 | |||
T83436 |
18β-Hydroxy-3-epi-α-yohimbine
|
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18β-Hydroxy-3-epi-α-yohimbine为育亨宾衍生物,该天然产物主要存在于Rauvolfia vomitoria中。 | |||
T79982 |
2'-epi-2'-O-Acetylthevetin B
GHSC-74 |
Apoptosis | Apoptosis |
2'-epi-2'-O-Acetylthevetin B (GHSC-74) 为源自Cerbera manghas L种子的强心苷,其抑制HepG2细胞增殖并诱导细胞凋亡(apoptosis)及线粒体膜电位降低。 | |||
TN3967 |
Epieriocalyxin A
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ERK; BCL; ROS; Caspase; DNA/RNA Synthesis; JNK | Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Immunology/Inflammation; MAPK; Proteases/Proteasome |
Epieriocalyxin A 可以抑制 Caco-2 结肠癌细胞的生长。它可能是未来结肠癌治疗的潜在药物。 | |||
T2856 |
(-)-Epicatechin
L-Epicatechin,表儿茶素,Epicatechin,(-)-Epicatechol,表儿茶精 |
Ferroptosis; COX; Endogenous Metabolite | Apoptosis; Immunology/Inflammation; Metabolism; Neuroscience |
(-)-Epicatechin (Epicatechin) 是一种 COX-1 的抑制剂,通过阻断 NF-κB 的 p65 亚基的核定位来抑制 IL-1β 诱导的 iNOS 表达。 | |||
T7177 |
Capsazepine
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Apoptosis; TRP/TRPV Channel | Apoptosis; Membrane transporter/Ion channel |
Capsazepine 是一种 TRPV1 受体的拮抗剂, IC50值为 562 nM。 它可阻断由激活 TRPV1 离子通道的辣椒素引起的热痛感,是辣椒素拮抗剂。 | |||
TN1608 |
(-)-Epigallocatechin-3-(3''-O-methyl) gallate
(-)-EGCG-3''-O-ME |
Antioxidant; Antibacterial | Microbiology/Virology; oxidation-reduction |
(-)-Epigallocatechin-3-(3''-O-methyl) gallate ((-)-EGCG-3''-O-ME) 是从茶叶中分离出的一种天然产物,具有很强的抗氧化、细胞毒性和抗菌活性,可增强蚀刻漂洗粘合剂与牙本质的粘合稳定性。 | |||
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Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-01030 |
TFPI Protein, Human, Recombinant (His)
TFPI1,tissue factor pathway inhibitor (lipoprotein-associate... |
Human | HEK293 Cells |
TFPI Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 30.6 kDa and the accession number is P10646-1. | |||
TMPK-00194 |
TFPI Protein, Human, Recombinant (His & Avi)
LACI,EPI,TFPI,convertin,TFI,TFPI1 |
Human | HEK293 Cells |
Oestrogens influence the pathophysiology and development of hormone-sensitive cancers, such as breast cancer. Tissue factor pathway inhibitor (TFPI) is a serine protease inhibitor of the extrinsic coagulation pathway and has recently been associated with breast cancer cell development. TFPI Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 32.1 kDa and the accession number is P10646-1. | |||
TMPK-00195 |
TFPI Protein, Human, Recombinant (His & Avi), Biotinylated
convertin,TFI,LACI,EPI,TFPI,TFPI1 |
Human | HEK293 Cells |
Oestrogens influence the pathophysiology and development of hormone-sensitive cancers, such as breast cancer. Tissue factor pathway inhibitor (TFPI) is a serine protease inhibitor of the extrinsic coagulation pathway and has recently been associated with breast cancer cell development. TFPI Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 32.1 kDa and the accession number is P10646-1. | |||
TMPY-00928 |
TFPI Protein, Mouse, Recombinant (His)
AW552122,A630013F22Rik,tissue factor pathway inhibitor (lipo... |
Mouse | HEK293 Cells |
TFPI Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 31 kDa and the accession number is O54819-1. | |||
TMPY-05179 |
TFPI Protein, Human, Recombinant (His), Biotinylated
TFI,TFPI1,EPI,LACI,tissue factor pathway inhibitor ... |
Human | HEK293 Cells |
TFPI Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 30.6 kDa and the accession number is P10646-1. | |||
TMPH-03583 |
Extracellular elastase Protein, S. epidermidis, Recombinant (His & Myc)
|
Staphylococcus epidermidis | E. coli |
Protease that has a low substrate specificity. Glucagon is preferentially cleaved between aromatic (Phe) and hydrophobic (Val) amino acids. Hydrolyzes casein and elastin. Extracellular elastase Protein, S. epidermidis, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 37.7 kDa and the accession number is P0C0Q4. | |||
TMPK-01416 |
HLA-B*15:01&B2M&SARS-CoV-2 epitope (NQKLIANQF) Monomer Protein, Human, MHC (His & Avi), Biotinylated
MHC,SARS-CoV-2 epitope |
Human | HEK293 Cells |
HLA-B*15:01 is strongly associated with asymptomatic infection with SARS-CoV-2 and is likely to be involved in the mechanism underlying early viral clearance. T cells from pre-pandemic individuals carrying HLA-B*15:01 were reactive to the immunodominant SARS-CoV-2 S-derived peptide NQKLIANQF, and 100% of the reactive cells displayed memory phenotype. | |||
TMPK-01412 |
HLA-B*15:01&B2M&SARS-CoV-2 epitope (NQKLIANQF) Monomer Protein, Human, MHC (His & Avi)
SARS-CoV-2 epitope,MHC |
Human | HEK293 Cells |
HLA-B*15:01 is strongly associated with asymptomatic infection with SARS-CoV-2 and is likely to be involved in the mechanism underlying early viral clearance. T cells from pre-pandemic individuals carrying HLA-B*15:01 were reactive to the immunodominant SARS-CoV-2 S-derived peptide NQKLIANQF, and 100% of the reactive cells displayed memory phenotype. | |||
TMPY-00023 |
Epiphycan Protein, Human, Recombinant (His)
epiphycan,DSPG3,Pg-Lb,PGLB,SLRR3B |
Human | HEK293 Cells |
Epiphycan Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36.1 kDa and the accession number is AAH30958.1. | |||
TMPY-02169 |
Epiregulin Protein, Human, Recombinant (hFc)
ER,epiregulin |
Human | HEK293 Cells |
Epiregulin Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 33.8 kDa and the accession number is O14944. | |||
TMPH-03075 |
3FTx-Oxy6 Protein, Oxyuranus microlepidotus, Recombinant (His & Myc & SUMO)
Three-finger toxin 3FTx-Oxy6 |
Oxyuranus microlepidotus | E. coli |
3FTx-Oxy6 Protein, Oxyuranus microlepidotus, Recombinant (His & Myc & SUMO) is expressed in E. coli. | |||
TMPH-03582 |
MazF Protein, S. epidermidis, Recombinant (His)
|
Staphylococcus epidermidis | E. coli |
Toxic component of a type II toxin-antitoxin (TA) system. Ribosome-independent, sequence-specific endoribonuclease that cleaves mRNA, thus inhibiting protein synthesis and inducing bacterial stasis. It cuts between the first and nucleotides of 5'-UACAU-3' in single-stranded RNA. Neutralized by coexpression with cognate antitoxin MazE. MazF Protein, S. epidermidis, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 19.0 kDa and the acce... | |||
TMPH-03581 |
Dihydrofolate reductase Protein, S. epidermidis, Recombinant (His)
dfrC,folA1,Dihydrofolate reductase,folA,DHFR |
Staphylococcus epidermidis | E. coli |
Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Dihydrofolate reductase Protein, S. epidermidis, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 22.0 kDa and the accession number is P0C0P1. | |||
TMPY-02166 |
Epiregulin Protein, Mouse, Recombinant (hFc)
epiregulin,EPR |
Mouse | HEK293 Cells |
Epiregulin Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 33.8 kDa and the accession number is Q61521. | |||
TMPH-00398 |
PPK2 Protein, Chlorobium tepidum, Recombinant (His & Myc)
|
Chlorobaculum tepidum | E. coli |
Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). PPK2 Protein, Chlorobium tepidum, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 34.4 kDa and the accession number is O68984. | |||
TMPH-03584 |
Shikimate dehydrogenase Protein, S. epidermidis, Recombinant (His & Myc)
|
Staphylococcus epidermidis | E. coli |
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). It can also use NAD to oxidize shikimate. Shikimate dehydrogenase Protein, S. epidermidis, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 37.4 kDa and the accession number is Q5HNV1. |