230
52
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T9882 |
RUVBL1/2 ATPase-IN-1
|
Others | Others |
RUVBL1/2 ATPase-IN-1 是一种有效的 RUVBL1/2 ATPase 抑制剂,IC50 值分别为 6.0 和 7.7 μM。 RUVBL1/2 ATPase-IN-1 可用于癌症疾病的研究。 | |||
T83967 |
ATPase-IN-3
|
ATPase | Membrane transporter/Ion channel |
ATPase-IN-3 是一种 ATP 酶 (ATPase) 抑制剂,可用于研究与代谢相关的疾病。 | |||
T61553 |
ATPase-IN-2
|
||
ATPase-IN-2 is a compound that acts as an inhibitor of ATPase, with an IC50 value of 0.9 μM. It also inhibits the glycohydrolase activity of C. difficile toxin B (TcdB) with an AC50 value of 30.91 μM. ATPase-IN-2 is commonly utilized in ATP-related research [1]. | |||
T0712 |
Suloctidil
|
ATPase; Platelet aggregation | Membrane transporter/Ion channel; Others |
Suloctidil 是一种外周血管扩张剂,作用于大鼠脑突触, 影响Na+/ K+ ATP 酶活性和膜流动性,可治疗痴呆和血栓形成病症。 | |||
T6443 |
Chloroprocaine hydrochloride
盐酸氯普鲁卡因,Chloroprocaine HCl |
ATPase; Others | Membrane transporter/Ion channel; Others |
Chloroprocaine hydrochloride (Chloroprocaine HCl) 是一种 Na/K-ATPase 活性抑制剂,IC50为 13 mM,可阻断外周神经。 | |||
T20626 |
Esomeprazole
|
Proton pump; Cysteine Protease | Membrane transporter/Ion channel; Proteases/Proteasome |
Esomeprazole 是奥美拉唑(omeprazole) 的S-异构体,抑制溶酶体半胱氨酸蛋白酶legumain,防止癌症转移。它是一种质子泵抑制剂(PPI)。 | |||
T0490 |
Chlorpropamide
Diabinese,氯磺丙脲 |
ATPase; ABC | Membrane transporter/Ion channel |
Chlorpropamide (Diabinese) 是口服降糖剂,可用于研究非胰岛素依赖型糖尿病。 | |||
T9008 |
NPD8733
|
Others | Others |
NPD8733 是癌细胞增强的成纤维细胞迁移抑制剂。它是与多种细胞活动 (AAA+) 蛋白家族相关的 ATP 酶的成员,能够与含 valosin 的蛋白 (VCP)/p97特异性结合,对癌症疾病具有潜在的研究价值。 | |||
T2176 |
2,3-Butanedione 2-Monoxime
Diacetyl monoxime,2,3-Butanedione-2-monoxime |
Akt | Cytoskeletal Signaling; PI3K/Akt/mTOR signaling |
2,3-Butanedione 2-Monoxime (Diacetyl monoxime) 是一种肌球蛋白 ATP 酶(myosin ATPase) 抑制剂。它诱导肌质网 Ca2+释放,能够有效抑制骨骼肌和心肌收缩。 | |||
T9230 |
KM 91104
|
ATPase | Membrane transporter/Ion channel |
KM 91104 是一种细胞通透性 V-ATPase 抑制剂,选择性作用于 V-ATPase 的 a3-b2 亚单位。 | |||
T3293 |
Apoptozole
Apoptosis Activator VII |
Apoptosis; HSP | Apoptosis; Cytoskeletal Signaling; Metabolism |
Apoptozole (Apoptosis Activator VII) 是一种Hsc70和Hsp70的 ATPase 结构域抑制剂,可诱导凋亡,Kd 值分别为 0.21 和 0.14 μM。 | |||
T6796 |
CB-5083
CB5083,CB 5083 |
p97 | Ubiquitination |
CB-5083 是一种有效的、选择性的、可口服的 p97 AAA ATPase 抑制剂,IC50为 11 nM。 | |||
T9168 |
NSC 617145
NSC617145,NSC-617145 |
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
NSC 617145 (NSC617145) 是一种 WRN 解旋酶抑制剂,IC50值为 230 nM。它以浓度依赖性方式抑制 WRN 解旋酶的 ATP 酶,并诱导双链断裂和染色体异常。 | |||
T36816 |
S-trityl-L-Cysteine
STLC |
Kinesin | Cytoskeletal Signaling |
S-Trityl-L-cysteine 是别构驱动蛋白Eg5的选择性抑制剂。rityl-L-cysteine 抑制基础 ATPase 活性的IC50为 1 μM,抑制微管激活的 ATPase 活性的IC50为 140 nM。S-Trityl-L-cysteine 显示出抗肿瘤活性。 | |||
T6700 |
Tenatoprazole
泰妥拉唑,TU-199 |
Proton pump | Membrane transporter/Ion channel |
Tenatoprazole (TU-199) 是一种口服有效的,基于咪唑吡啶的质子泵抑制剂。它抑制猪胃H+/K+-ATP 酶活性,IC50为6.2 μM。它阻断泛素与 ESCRT-1 因子 Tsg101 的相互作用,抑制几种包膜病毒的产生,包括 EBV。 | |||
T6953 |
Prilocaine
Citanest,丙胺卡因,Propitocaine,NSC 40027 |
ATPase; Sodium Channel | Membrane transporter/Ion channel |
Prilocaine (NSC-40027) 是一种氨基酰胺类局部麻醉剂,作用于神经元膜上的钠通道并限制癫痫发作的扩散。它是Na/K-ATPase 抑制剂,具有神经毒性作用。 | |||
T2686L |
Esomeprazole Sodium
埃索美拉唑钠,(S)-Omeprazole sodium |
ATPase; Proton pump | Membrane transporter/Ion channel |
Esomeprazole Sodium ((S)-Omeprazole sodium) 是一种口服有效的活性质子泵抑制剂。Esomeprazole sodium 通过抑制胃壁细胞中的 H+, K+-ATPase 来降低酸分泌,在胃食管反流疾病中有研究价值。Esomeprazole 是一种外泌体抑制剂,通过抑制 V-H+-ATPases 来阻断外泌体的释放。 | |||
T2621 |
Rostafuroxin
PST 2238 |
ATPase; RSV | Membrane transporter/Ion channel; Microbiology/Virology |
Rostafuroxin (PST 2238) 是洋地黄毒苷衍生物,是一种口服有效的 Na+,K+-ATPase 抑制剂,具有抗高血压和抗 RSV 活性,用于研究治疗原发性高血压的试验。 | |||
T0796 |
Prilocaine hydrochloride
Prilocaine HCl,Propitocaine hydrochloride,Xylonest,盐酸丙胺卡因 |
ATPase; Sodium Channel | Membrane transporter/Ion channel |
Prilocaine hydrochloride (Prilocaine HCl) 是一种氨基酰胺类局部麻醉剂,作用于神经元膜上的钠通道并限制癫痫发作的扩散。它是Na/K-ATPase 抑制剂,具有神经毒性作用。 | |||
T1734 |
Rabeprazole Sulfide
雷贝拉唑相关物质E,Rabeprazole Related Compound E |
Proton pump; Antibacterial | Membrane transporter/Ion channel; Microbiology/Virology |
Rabeprazole Sulfide (Rabeprazole Related Compound E) 是 Rabeprazole 的活性代谢产物。Rabeprazole 是一种质子泵抑制剂类的抗溃疡药物,有效抑制幽门螺旋杆菌的活性,可通过与胃壁细胞中的(H+/K+)-ATPase 相互作用来抑制胃酸分泌,可研究各种消化系统疾病。 | |||
T10616 |
BRM/BRG1 ATP Inhibitor-1
|
Epigenetic Reader Domain | Chromatin/Epigenetic |
BRM/BRG1 ATP Inhibitor-1 是变构双 Brahma 同源物 (BRM)/SWI/SNF 相关的基质相关肌动蛋白依赖性调节剂,染色质亚家族 A 成员 2 和 BRG1/SMARCA4 ATP 酶活性抑制剂,IC50值低于 0.005 μM。 | |||
T7144 |
BTS
N-Tosylbenzylamine,N-苄基-对甲苯磺酸胺,N-Benzyl-p-toluenesulfonamide |
ATPase; Myosin | Cytoskeletal Signaling; Membrane transporter/Ion channel |
BTS (N-Tosylbenzylamine) 是一种选择性骨骼肌肌球蛋白 II 亚片段 1 (S1) ATPase 活性抑制剂,可特异性抑制骨骼肌快速纤维的收缩。它对肌动蛋白和 Ca2+刺激的肌球蛋白 S1 ATPase 的 IC50值约为 5 µM。 | |||
T2686 |
Esomeprazole Magnesium
(S)-Omeprazole magnesium,NEXIUM,埃索美拉唑镁,(-)-Omeprazole magnesium |
ATPase; Proton pump | Membrane transporter/Ion channel |
Esomeprazole Magnesium (NEXIUM) 是一种口服有效的 H+, K+-ATPase 抑制剂,在上消化道疾病和胃食管反流疾病中具有研究价值。Esomeprazole magnesium 是一种外泌体抑制剂,通过抑制 V-H+-ATPases 来阻断外泌体的释放。 | |||
T6928 |
Pantoprazole
SKF96022,泮托拉唑,BY1023 |
Apoptosis; Proton pump; Autophagy | Apoptosis; Autophagy; Membrane transporter/Ion channel |
Pantoprazole (BY1023) 是一种质子泵抑制剂,用于短期治疗由胃食管反流病引起的食管糜烂和溃疡。它联合阿霉素可显著增加肿瘤生长延迟。它是一种取代的苯并咪唑,是H+/K+-ATPase 抑制剂,可改善 pH 值稳定性,具有抗分泌和抗溃疡的作用。 | |||
T8386 |
Esomeprazole Magnesium trihydrate
埃索美拉唑镁三水合物,埃索美拉唑镁(三水),(S)-Omeprazole magnesium trihydrate |
Proton pump | Membrane transporter/Ion channel |
Esomeprazole Magnesium trihydrate ((S)-Omeprazole magnesium trihydrate) 是一种口服有效的H+, K+-ATPase 抑制剂,在上消化道疾病和胃食管反流疾病的研究中具有价值。它是一种外泌体抑制剂,通过抑制 V-H+-ATPases 来阻断外泌体的释放。 | |||
T1651 |
Rabeprazole sodium
Dexrabeprazole Sodium,LY307640 sodium,Habeprazole Sodium,雷贝拉唑钠,Rebeprazole sodium,Aciphex Sodium |
Apoptosis; Proton pump | Apoptosis; Membrane transporter/Ion channel |
Rabeprazole sodium (Habeprazole Sodium) 是一种质子泵抑制剂,不可逆地抑制胃 H+/K+-ATPase,可研究胃溃疡和胃食管反流。它诱导细胞凋亡,也抑制尿苷核苷核糖水解酶 ,IC50为 0.3 μM。 | |||
T0161 |
Pantoprazole Sodium Hydrate
SKF96022 sodium hydrate,泮托拉唑钠水合物,BY1023 (sodium hydrate),SKF96022 (sodium hydrate) |
Apoptosis; Potassium Channel; Proton pump; Autophagy | Apoptosis; Autophagy; Membrane transporter/Ion channel |
Pantoprazole Sodium Hydrate (BY1023 (sodium hydrate)) 是一种具有口服活性的质子泵抑制剂。它是取代的苯并咪唑,是H+/K+-ATPase 抑制剂。它可改善 pH 值稳定性,具有抗分泌和抗溃疡的作用。它联合阿霉素可显著增加肿瘤生长延迟。 | |||
T6929 |
Pantoprazole sodium
Pantecta,泮托拉唑钠盐,SKF96022 sodium,SKF96022 (sodium),BY1023 (sodium),泮托拉唑钠,BY-1023 sodium,Pantoloc |
Apoptosis; Others; Proton pump; HIF; Autophagy | Angiogenesis; Apoptosis; Autophagy; Chromatin/Epigenetic; Membrane transporter/Ion channel; Others |
Pantoprazole sodium (Pantecta) 是一种具有口服活性的质子泵抑制剂,是一种取代的苯并咪唑,是H+/K+-ATPase 抑制剂,IC50为 6.8 μM。它可以改善 pH 值稳定性,具有抗分泌和抗溃疡的作用。它联合阿霉素可显著增加肿瘤生长延迟。 | |||
T27812 |
Leminoprazole
|
ATPase | Membrane transporter/Ion channel |
Leminoprazole 是一种可口服的 H+,K(+)-ATPase 抑制剂,可保护胃黏膜细胞免受各种细胞损伤,可用于治疗胃溃疡。 | |||
T7540 |
2,5-Di-tert-butylhydroquinone
BHQ,2,5-二特丁基对苯二酚 |
Calcium Channel; Lipoxygenase; COX | Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience |
2,5-Di-tert-butylhydroquinone (BHQ) 是一种有效和选择性的内质网 Ca2+-ATPase 抑制剂,可调节5-LO 以及COX-2活性,IC50分别为 1.8 和 14.1 μM。 | |||
T22280 |
BRITE-338733
BRITE338733 |
ATPase; Antibacterial | Membrane transporter/Ion channel; Microbiology/Virology |
BRITE-338733 是一种新型ATPase 抑制剂,抑制 RecA 在细菌中的表达,IC50 值为 4.7 µM,用于治疗细菌感染。 | |||
T2404 |
Vonoprazan fumarate
富马酸沃诺拉赞,TAK-438 |
ATPase | Membrane transporter/Ion channel |
Vonoprazan fumarate (TAK-438) 是一种新型 P-CAB(钾竞争性酸阻滞剂),可可逆地抑制 H+/K+、ATP 酶。 | |||
T7134 |
Mavacamten
MYK-461,SAR439152 |
Myosin | Cytoskeletal Signaling |
Mavacamten (MYK-461) 是一种可口服的心肌肌球蛋白 ATP 酶抑制剂,在牛心脏和人心脏中的IC50值分别为 490和711 nM。 | |||
T21254 |
Vonoprazan Fumarate
TAK-438,TAK 438,Vonoprazan Fumurate,TAK438,富马酸沃诺拉赞 |
Proton pump | Membrane transporter/Ion channel |
Vonoprazan Fumarate (TAK438) 是质子泵的有效抑制剂,是口服有效的高效钾竞争性酸阻断剂,具有抗分泌活性。在 pH 为 6.5 时,它抑制猪胃微粒体中的 H+,K+-ATPase 酶活性,IC50为 19 nM。它被开发用于研究酸相关疾病,如消化性溃疡和胃食管反流病。 | |||
T17030 |
Tegoprazan
|
ATPase; Proton pump | Membrane transporter/Ion channel |
Tegoprazan 是一种口服有效的、高选择性胃 H+/K+-ATP 酶 (H+/K+-ATPase) 抑制剂,能够控制胃酸分泌和运动,在体外检测的对猪、犬、人的 H+/K+-ATP 酶的 IC50为0.29-0.52 μM。 | |||
T9553 |
8-[(2,6-dimethylbenzyl)amino]-2,3-dimethylimidazo[1,2-a]pyridine-6-carboxylic acid
|
Others | Others |
8-[(2,6-dimethylbenzyl)amino]-2,3-dimethylimidazo[1,2-a]pyridine-6-car 是一种 H+/K+ ATPase 抑制剂,IC50=0.38μM。 | |||
T2189 |
Sodium orthovanadate
Sodium vanadate,钒酸钠,Trisodium vanadate,Sodium pervanadate |
ATPase; Phosphatase | Membrane transporter/Ion channel; Metabolism |
Sodium orthovanadate 是一种蛋白酪氨酸磷酸酶,碱性磷酸酶和一些ATP 酶的抑制剂,有可能充当磷酸盐类似物。它具有胰岛素样作用、对心室肌的正性肌力作用和其他代谢作用。 | |||
T16865 |
SCH28080
|
ATPase; Proton pump | Membrane transporter/Ion channel |
SCH28080 是一种可逆且具有 K+ 竞争性的胃 H+/K+-ATP 酶 (H+/K+-ATPase) 抑制剂,IC50 值为 20 nM (家兔微粒体膜)。SCH28080 在体内是有效的酸分泌抑制剂,具有抗溃疡活性、抗分泌和细胞保护活性。 | |||
T12503 |
(+)-Blebbistatin
|
Others | Others |
(+)-Blebbistatin 是 (–)-Blebbistatin 的非活性对映异构体。 (–)-Blebbistatin 是一种选择性肌球蛋白 II ATPase 抑制剂。 | |||
T7373 |
CDN1163
|
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
CDN1163 是肌膜/内质网 Ca2+-ATPase (SERCA)的变构激活剂,可改善 Ca2+稳态,可减轻糖尿病和代谢紊乱。 | |||
T60032 |
BRM/BRG1 ATP Inhibitor-2
|
Epigenetic Reader Domain | Chromatin/Epigenetic |
BRM/BRG1 ATP Inhibitor-2 是 BRG1/BRM ATPase 的抑制剂,可用于治疗 BAF 相关疾病的研究。 | |||
T17313 |
(+)-SJ733
SJ000557733 |
ATPase; Parasite | Membrane transporter/Ion channel; Microbiology/Virology |
(+)-SJ733 (SJ000557733) 是一种有效的 Na+-ATPase PfATP4 抑制剂,具有抗疟活性,可用于研究疟疾。 | |||
T67763 |
PK095
|
ATPase | Membrane transporter/Ion channel |
PK095是一个基于胍的F1F0-ATPase 抑制剂家族。 | |||
T2039 |
GSK-923295
|
Apoptosis; Kinesin | Apoptosis; Cytoskeletal Signaling |
GSK923295 是一种特异性的变构着丝粒相关蛋白-E 驱动蛋白 ATPase 活性抑制剂,作用于人类和犬类此酶,Ki 分别为 3.2±0.2 nM 和 1.6±0.1 nM。 | |||
T13848 |
SMARCA-BD ligand 1 for Protac
|
Epigenetic Reader Domain | Chromatin/Epigenetic |
SMARCA-BD ligand 1 for Protac 能够与 BAF ATPase 亚基 SMARCA2 结合,可用于 PROTAC 技术,用于降解 SMARCA2。 | |||
T28136 |
NC-1300-B
NC1300B,NC 1300 B |
ATPase | Membrane transporter/Ion channel |
NC-1300-B 抑制 H(+)-K(+)-ATP 酶,可用于研究胃溃疡。 | |||
T14965 |
Ciliobrevin D
|
ATPase; Hedgehog/Smoothened | GPCR/G Protein; Membrane transporter/Ion channel; Stem Cells |
Ciliobrevin D 是细胞渗透性,可逆和特异性的 AAA + ATPase 运动细胞质动力蛋白抑制剂。它在体外抑制依赖于动力蛋白的微管滑动和 ATPase 活性。它抑制Hedgehog 信号和初级纤毛形成。 | |||
T20436 |
DHQ
2,3-dihydroxy-quinoxalin,2,3-二羟基喹喔啉 |
ATPase | Membrane transporter/Ion channel |
DHQ (2,3-dihydroxy-quinoxalin) 是单纯疱疹病毒胸苷激酶的 ATPase 活性诱导剂。 | |||
T10435 |
Linaprazan
利那拉生,AZD0865 |
Potassium Channel | Membrane transporter/Ion channel |
Linaprazan (AZD0865) 通过K+竞争抑制胃中的H+,K+ -ATPase. (IC 50: 1.0 ± 0.2 μM)。Linaprazan 对酸有很强的抑制作用。 | |||
T27303 |
Farglitazar
GI-262570,GI 262570,GI262570 |
||
Farglitazar is a PPAR-γ agonist. GI262570 stimulates the ENaC and Na,K-ATPase system resulting in the increasing of water and sodium reabsorption in distal nephron. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T1719 |
Bufalin
|
ATPase | Membrane transporter/Ion channel |
Bufalin 是蟾酥中的一种成分,是Na+/K+-ATPase 抑制剂,具有抗肿瘤活性,可与其基 α1、α2 和 α3 结合,Kd 值分别为 42.5、45 和 40 nM。 | |||
TJP2872 |
Acevaltrate
Acevaltratum,乙酰缬草三酯,Acetoxyvaltrate |
ATPase; Others | Membrane transporter/Ion channel; Others |
Acevaltrate (Acevaltratum) 对人小细胞肺癌细胞系 GLC(4) 和人结肠直肠癌细胞系 COLO 320 具有高细胞毒性,IC50 值为 1-6 uM。它抑制大鼠肾和脑半球中 Na+/K+-ATP 酶活性,IC50分别为 22.8 和 42.3 μM。 | |||
T5S0890 |
Oleandrin
Neriostene,Folinerin,Foliandrin,欧夹竹桃苷 |
Apoptosis; ATPase; Potassium Channel; Sodium Channel | Apoptosis; Membrane transporter/Ion channel |
Oleandrin (Folinerin) 是夹竹桃属中的一种类固醇,可抑制Na+/K+-ATPase 活性,IC50为 620 nM。 | |||
T0295 |
Digitoxin
Digitoxoside,洋地黄毒苷,Unidigin,洋地黄毒甙,Digitoxinum,洋地黄 |
ATPase; Others | Membrane transporter/Ion channel; Others |
Digitoxin (Digitoxinum) 是Na+/K+-ATPase 有效抑制剂, EC50 值为0.78 μM。 | |||
TN5073 |
Strophanthidin
毒毛旋花子甙元,Strophanthidine,葡萄球菌素 |
ATPase; Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Strophanthidin (Strophanthidine) 是黄花夹竹桃中的一种类固醇,可增加舒张期和收缩期胞内 Ca2+浓度。它在 0.1 和 1 nmol/L 增加Na+/K+-ATPase 活性,1到100 μ mol/L 抑制Na+/K+-ATPase 活性,10 和 100 nmol/L 对Na+/K+-ATPase 活性无影响。 | |||
T2922 |
Phlorizin
Floridzin,根皮甙,根皮苷,NSC 2833,Phloridzin |
ATPase; SGLT | GPCR/G Protein; Membrane transporter/Ion channel |
Phlorizin (Phloridzin) 是非选择性的SGLT 抑制剂,也是Na+/K+-ATPase 抑制剂,对于hSGLT1和hSGLT2的Ki 值分别为 300 和 39 nM。 | |||
T8183 |
Deslanoside
洋地黄,去乙酰西地兰,Desacetyllanatoside C,Deacetyllanatoside C |
ATPase; Drug Metabolite | Membrane transporter/Ion channel; Metabolism |
Deslanoside (Desacetyllanatoside C) 是一种快速作用的强心苷,可抑制Na-K-ATPase 膜泵,导致细胞内钠和钙浓度增加。它用于研究充血性心力衰竭和因折返机制引起的室上性心律失常,并在研究慢性心房颤动时控制心室率。 | |||
T2O2668 |
Oleic acid
Elaidoic acid,9Z-Octadecenoic acid,Oleate,9-Octadecenoic Acid,Glycon Wo,9-cis-Octadecenoic acid,油酸 |
Apoptosis; ATPase; Others; Endogenous Metabolite | Apoptosis; Membrane transporter/Ion channel; Metabolism; Others |
Oleic acid (Glycon Wo) 属于天然产物,是一种常见的饱和脂肪酸,在存在于多种动物、植物的脂肪和油脂中。Palmitic acid 是一种 Na+/K+ATP 酶激活剂。 | |||
T6368 |
Abscisic Acid
Abscisin II,Dormin,(+)-脱落酸,(+)-ABA,Abscisic Acid (Dormin) |
Others; Proton pump; Endogenous Metabolite | Membrane transporter/Ion channel; Metabolism; Others |
Abscisic Acid (Dormin) 是具有口服活性的植物激素,存在于蔬菜和水果中,也是内源性的哺乳动物激素。它是生长抑制剂,可以调节植物生长发育。他抑制质子泵,并导致 Ca2+依赖性的质膜去极化。它是 LANCL2 的天然配体,属于胰岛素敏感化合物,在糖尿病前期,2 型糖尿病和代谢综合征的研究中具有价值。 | |||
T2822 |
Ginsenoside Rb1
Gypenoside Ⅲ,人参皂苷Rb1,人参皂苷 Rb1,Gypenoside III |
ATPase; Mitophagy; IRAK; NF-κB; Autophagy; HSV | Autophagy; Immunology/Inflammation; Membrane transporter/Ion channel; Microbiology/Virology; NF-κB |
Ginsenoside Rb1 (Gypenoside Ⅲ) 是中药人参的成分,可能具有抑制或阻止肿瘤生长的特性。 | |||
T6062 |
Brefeldin A
BFA,布雷非德菌素 A,Ascotoxin,Cyanein,Decumbin |
ATPase; Mitophagy; Antibiotic; Autophagy; HSV; CRISPR/Cas9 | Autophagy; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Microbiology/Virology |
Brefeldin A (Cyanein) 属于大环内酯类抗生素,是一种 ATPase 抑制剂 (IC50=0.2 μM)。Brefeldin A 可以诱导肿瘤细胞分化和凋亡,也具有抑制自噬的活性。 | |||
TN1860 |
Licoflavone B
甘草黄酮 B,甘草黄酮B |
ATPase; Anti-infection; Parasite | Membrane transporter/Ion channel; Microbiology/Virology |
Licoflavone B 是从甘草中得到的一种类黄酮,抑制曼氏血吸虫 ATPase 和 ADPase 的活性,IC50值分别为 23.78 µM 和 31.50 µM。 | |||
TN1103 |
Diphyllin
山荷叶素,二叶草素 |
ATPase; Proton pump; Influenza Virus; HIV Protease | Membrane transporter/Ion channel; Microbiology/Virology; Proteases/Proteasome |
Diphyllin 是一种从Justicia procumbens 中分离的芳基萘木脂素,是HIV-1的有效抑制剂,IC50 为 0.38 μM。它是V-ATPase 抑制剂,IC50值为 17 nM,可抑制人破骨细胞中的溶酶体酸化。它抑制NO 产生,IC50值为 50 μM ,具有抗癌和抗炎活性。 | |||
T3432 |
Cinobufagin
华蟾蜍精,华蟾酥毒基,Cinobufagine |
Apoptosis; ATPase; Autophagy | Apoptosis; Autophagy; Membrane transporter/Ion channel |
Cinobufagin (Cinobufagine) 是一种具有抗肿瘤功效的天然产物。 | |||
T15027 |
Cyclopiazonic acid
环匹阿尼酸,环二氮酸 |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Cyclopiazonic acid 是一种神经毒性次级代谢产物 (SM),源于A. flavus,是一种纳摩尔内质网钙 ATP 酶抑制剂 (Ca2+ATPase; SERCA),是植物细胞死亡的有效诱导剂。 | |||
TQ0184 |
Chebulinic acid
|
ATPase; Proton pump; DNA/RNA Synthesis; Antibacterial; TGF-beta/Smad | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Microbiology/Virology; Stem Cells |
Chebulinic acid 是从诃子果中提取的一种天然产物,结核分枝杆菌 DNA 促旋酶的有效抑制剂。它也能抑制 SMAD-3 phosphorylation 和 H+ K+-ATPase 的活性。 | |||
T6323 |
Oligomycin A
MCH 32,寡霉素A |
ATPase; Antibiotic; Antifungal | Membrane transporter/Ion channel; Microbiology/Virology |
Oligomycin A (MCH 32) 是从链霉菌属中得到的一种线粒体F0F1-ATPase 抑制剂,抑制氧化磷酸化和线粒体偶联膜上发生的所有 ATP 依赖性过程。 | |||
T6740 |
Bafilomycin A1
巴佛洛霉素A1,巴佛洛霉素 A1 |
Apoptosis; Proton pump; Antibacterial; Antibiotic; Autophagy | Apoptosis; Autophagy; Membrane transporter/Ion channel; Microbiology/Virology |
Bafilomycin A1 属于大环内酯类抗生素,是一种 V-ATPase (IC50=0.44 nM),具有特异性和可逆性。Bafilomycin A1 是自噬晚期阶段抑制剂,阻断自噬体与溶酶体的融合。Bafilomycin A1 也诱导凋亡。 | |||
T3926 |
Echinatin
刺甘草查尔酮,Retrochalcone |
Free radical scavengers | oxidation-reduction |
Echinatin (Retrochalcone) 是分离自中草药甘草中,具有保肝和抗炎活性。在大鼠中,它可以被快速吸收和消除,并广泛分布,绝对生物利用度约为 6.81%。 | |||
T36390 |
Sodium oleate
Oleic acid sodium salt,Sodium oleate,cis-9-Octadecenoic acid sodium salt |
ATPase | Membrane transporter/Ion channel |
Sodium oleate (cis-9-Octadecenoic acid sodium salt) (Oleic acid sodium) 是人脂肪细胞和其他组织中最常见的单不饱和脂肪酸钠盐。Sodium oleate 是一种 Na+/K+ ATP 酶激活剂。 | |||
T0974 |
Novobiocin Sodium
Albamycinsodium,新生霉素钠,Cathomycin,Albamycin |
Potassium Channel; DNA gyrase; Topoisomerase; Antibacterial; Antibiotic; ABC; Autophagy | Autophagy; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Microbiology/Virology |
Novobiocin Sodium (Albamycinsodium) 是源自 Streptomyces niveus 的抗生素。 它的化学结构类似于香豆素。Novobiocin 与 DNA 促旋酶结合并阻断三磷酸腺苷活性。 | |||
T3868 |
Agnuside
牡荆油,穗花牡荆苷,chasteberry oil |
COX; Prostaglandin Receptor; P-gp | GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel; Neuroscience |
Agnuside (chasteberry oil) 是从黄荆中分离得到的一种天然产物,可下调炎性介质PGE2和LTB4,减少细胞因子的表达,具有抗关节炎活性。 | |||
T4897 |
Inosine-5'-triphosphate trisodium salt
ITP,肌苷-5'-三磷酸三钠盐,三磷酸肌苷三钠盐,Inosine 5'-triphosphate trisodium salt |
Others; Endogenous Metabolite | Metabolism; Others |
Inosine-5'-triphosphate trisodium salt (ITP) 是三磷酸核苷,能够作为 ATPases 和 GTPases 的底物。 | |||
TQ0302 |
Thapsigargin
毒胡萝卜素 |
Apoptosis; SARS-CoV; Calcium Channel | Apoptosis; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology |
Thapsigargin 属于天然产物,是一种肌/内质网 Ca2+ ATP 酶 (SERCA) 的抑制剂,也是一种内质网应激诱导剂。Thapsigargin 通过阻断细胞将钙泵入肌浆和内质网的能力来提高胞浆钙浓度。 | |||
T5079 |
Adenosine 5'-diphosphate sodium salt
腺苷-5‘-二磷酸钠盐,Adenosine-5'-diphosphate trisodium salt,ADP sodium salt |
Others; Endogenous Metabolite | Metabolism; Others |
Adenosine 5'-diphosphate sodium salt (ADP sodium salt) 是一种核苷二磷酸,是一种 ATP 酶对 ATP 去磷酸化的产物。它通过在 P2T-嘌呤受体上的作用诱导人血小板聚集并抑制刺激的腺苷酸环化酶。 | |||
T10662L |
Calcimycin
Antibiotic A-23187,离子载体(钙镁盐混合物),A-23187 |
Apoptosis; Antibacterial; Antibiotic; Autophagy; Antifungal | Apoptosis; Autophagy; Microbiology/Virology |
Calcimycin (A-23187) 是抗生素和二价阳离子离子载体。它抑制革兰氏阳性细菌和一些真菌生长,也抑制 ATP 酶的活性并解耦哺乳动物细胞的氧化磷酸化。它通过增加细胞内钙浓度诱导 Ca2+依赖性细胞死亡。 | |||
T4973 |
Paraxanthine
1,7-二甲基黄嘌呤,1,7-DIMETHYLXANTHINE |
Endogenous Metabolite | Metabolism |
Paraxanthine (1,7-dimethylxanthine) 是一种 caffeine 的代谢物,能够刺激Ryanodine 受体通道来抑制多巴胺能细胞的死亡。 | |||
T6S1049 |
Wilforine
|
ATPase | Membrane transporter/Ion channel |
Wilforine 是一倍半萜吡啶化合物,T. wilfordii 植物中的重要生物活性化合物,可有效治疗特发性肺纤维化。它具有抗炎和杀虫活性。 | |||
T5075 |
Phytic acid potassium
植酸二钾盐,Inositol hexakisphosphate dipotassium salt,Phytic acid dipotassium salt,Fytic Acid dipotassium salt,Inositol polyphosphate dipotassium salt |
Others; Endogenous Metabolite | Metabolism; Others |
Phytic acid potassium (Inositol polyphosphate dipotassium salt) 是内源性代谢产物的一种。 | |||
T7190 |
Actein
|
Apoptosis; Akt; JNK; Autophagy | Apoptosis; Autophagy; Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling |
Actein 是从升麻的根茎中分离的一种三萜糖苷,通过促进ROS/JNK 活化和钝化人膀胱癌中的AKT 途径来抑制细胞增殖,诱导自噬和凋亡。 | |||
T5S1982 |
Periplocin
Periplocoside,杠柳毒苷 |
Apoptosis; Others | Apoptosis; Others |
Periplocin (Periplocoside) 是从黑龙骨中分离出的一种强心类固醇。它可促进肿瘤细胞凋亡并抑制肿瘤生长。它通过激活 Na/K-ATPase 介导的 Src/ERK 和 PI3K/Akt 途径,具有促进伤口愈合的潜力。 | |||
T13618 |
Citreoviridin
|
Others | Others |
Citreoviridin, a toxin from Penicillium citreoviride NRRL 2579, inhibits brain synaptosomal Na+/K+-ATPase whereas, in microsomes, both Na+/K+-ATPase and Mg2+-ATPase activities are significantly stimulated in a dose-dependent manner. | |||
T38609 | Mycalolide B | ||
Mycalolide-B is a marine sponge-derived compound that functions as a selective inhibitor of actomyosin ATPase. It effectively hinders ATP-induced contraction and Mg2+-ATPase activity in the absence of Ca2+. | |||
T14995 |
Concanamycin A
X 4357B,刀豆素A,Antibiotic X 4357B,Concanamycin |
Others | Others |
Concanamycin A is a macrolide antibiotic. It also is a specific inhibitor of vacuolar-type H+-ATPase (V-ATPase). | |||
TN6631 |
Chamigrenol
|
||
Chamigrenol is a promising candidate for the development of potent Na+/K+ ATPase inhibitors and antimicrobial agents. It inhibited the activities of Na+/K+-ATPase, with the IC50 value of 15.9 ± 0.54 μg/mL. | |||
T25211 |
CC 1014
CC1014,CC-1014,NSC-356885,NSC356885,NSC 356885 |
||
CC 1014 is a polypeptide antibiotic isolated from Penicillium lilacinum that inhibits phosphorylation of ADP, Mg ATPase. | |||
TN5141 |
Thevetin B
|
ATPase; Potassium Channel; Sodium Channel | Membrane transporter/Ion channel |
Thevetin B 是一种强心苷,是Na+-, K+-依赖性腺苷三磷酸酶 (Na+,K+-ATPase) 的抑制剂,来自 Thevetia peruviana。 | |||
TN4697 |
Odoroside H
|
ATPase; Potassium Channel; Sodium Channel | Membrane transporter/Ion channel |
Odoroside H has anticancer activities, the cytotoxic effects are induced by the inhibition of the plasma membrane bound Na(+)/K(+)-ATPase. | |||
TN3914 | Echinatine | ATPase; IL Receptor; TNF | Apoptosis; Immunology/Inflammation; Membrane transporter/Ion channel |
Echinatin exerts a protective effect against ischemia/reperfusion (I/R)-induced myocardial injury on hearts, this effect may be attributed to the antioxidant and anti-inflammatory activities of this compound. Echinatin can inhibit DNP-ATPase activity whil | |||
T10455 |
Bafilomycin B1
巴佛洛霉素 B1 |
Others | Others |
Bafilomycin B1, a macrolide antibiotic isolated from Streptomyces sp, acts as an inhibitor of K+-dependent ATPase of E. coli. It also inhibits Gram-positive bacteria and fungi. | |||
T14293 |
Annonacin
|
Others | Others |
Annonacin is an Acetogenin and promotes cytotoxicity via a pathway inhibiting the mitochondrial complex and it is the active agent found in Graviola leaf extract to act as an inhibitor of sodium/potassium (NKA) and sarcoplasmic reticulum (SERCA) ATPase pu | |||
TN2306 | Wilfordine | ATPase; Potassium Channel; Sodium Channel | Membrane transporter/Ion channel |
Wilfordine is an insecticidally active alkaloid, Na+-K+-ATPase may be an acting target of wilfordine against some larvae of insect. | |||
T16719 |
Radicicol
根赤壳菌素,Monorden |
HSP | Cytoskeletal Signaling; Metabolism |
Radicicol is an antifungal antibiotic, impairs mitochondrial replication by targeting P. falciparum topoisomerase VIB. Radicicol is an inhibitor of Hsp90 (IC50: 1 μM). Radicicol binds to the ATPase domain of Hsp90 and prevents maturation of Hsp90 clients, | |||
TN5060 |
Stauntosaponin A
|
ATPase; Potassium Channel; Sodium Channel | Membrane transporter/Ion channel |
Stauntosaponin A and stauntosaponin B show moderate inhibitory activities against Na+/K+-ATPase with IC50 values of 21 and 29 uM, respectively. | |||
T23610 |
Acerinol
|
||
Acerinol is an active ingredient from traditional Chinese medicinal herbs. It could be used as a cancer multidrug resistance reversal agent. Acerinol can significantly stimulate the activity of ABCB1 ATPase without affecting the expression of ABCB1 on nei | |||
TN3075 | 5,2',6'-Trihydroxy-6,7,8-trimethoxyflavone | ATPase | Membrane transporter/Ion channel |
5,2',6'-Trihydroxy-6,7,8-trimethoxyflavone (ED 50 =4.5 ug/ml ) shows cytotoxicity against L1210 cell and has inhibiting effects on ATPase from the cell. | |||
T35605 |
Apoptolidin
|
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Apoptolidin is an apoptosis inducer originally isolated from Nocardiopsis bacteria. It inhibits the mitochondrial F1FO ATPase (Ki = 4-5 μM). Apoptolidin selectively kills transformed glial cells without significantly affecting untransformed cells. It also has antibiotic and antifungal actions. | |||
T27977 |
Manzamine A
Keramamine A |
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Manzamine A is a GSK-3 inhibitor and vacuolar ATPase uncoupler found in marine sponges. It inhibits autophagy and tumor growth in cancer models, suppresses foam cell formation in macrophages, prevents growth of gram negative and gram positive bacteria, an | |||
T38069 |
Aquastatin A
|
||
Aquastatin A is a fungal metabolite originally isolated fromF. aquaeductuumthat has diverse biological activities.1It is active againstS. aureus(MIC = 32 μg/ml) and inhibits enoyl-acyl carrier protein reductase (Fabl; IC50= 3.2 μM) andS. aureusfatty acid synthesis (IC50= 3.5 μM).2Aquastatin A also inhibits the Na+/K+-ATPase and H+/K+-ATPase (IC50s = 7.1 and 6.2 μM, respectively), as well as protein tyrosine phosphatase 1B (PTP1B; IC50= 0.19 μM).1,3 1.Hamano, K., Kinoshita-Okami, M., Minagawa, K.... | |||
T72645 |
Norbatzelladine L
|
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Norbatzelladine L 是一种 Pdr5p 转运蛋白催化活性和功能活性的抑制剂。Norbatzelladine L 抑制 Pdr5p ATPase 活性,IC50值为 3.8 µM。Norbatzelladine L 具有抗真菌 (antifungal)、抗寄生虫 (antiparasitic)、抗病毒 (antiviral)、抗细菌 (antibacterial) 和抗肿瘤活性。 | |||
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