首页工具

登录

搜索结果

Search Results for " stabilizing "

60

抑制剂 & 化合物

15

天然产物

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
T79508	Microtubule stabilizing agent-1
	Microtubule stabilizing agent-1 (compound 3l)，作为一种紫杉醇衍生物，能够有效地促进微管蛋白聚合 (tubulin polymerization)，并且展现了显著的抗肿瘤效能。
T7806	Licarbazepine 10,11-hydroxy-10,11 Dihydrocarbamezer,10,11-二氢-10-羟基卡马西平	Others	Others
	Licarbazepine (10,11-hydroxy-10,11 Dihydrocarbamezer) 是一种有效的电压门控钠通道阻滞剂，具有抗惊厥和稳定情绪的功效。
T9409	Mesdopetam hemitartrate IRL790 hemitartrate,1-Propanamine, N-[2-[3-fluoro-5-(methylsulfonyl)phenoxy]ethyl]-, (2R,3R)-2,3-dihydroxybutanedioate (2:1)	Dopamine Receptor	GPCR/G Protein; Neuroscience
	Mesdopetam hemitartrate (IRL790 hemitartrate) 是一种多巴胺D3受体拮抗剂 (Ki=90 nM;IC50=9.8 μM)，具有稳定精神运动的作用，可用于帕金森病的运动和精神并发症的研究。
T74166	Microtubule destabilizing agent-1
	Microtubule destabilizing agent-1 (Compound 12b)为基于异羟肟酸的微管去稳定剂(MDA)。该化合物表现出良好的代谢稳定性、高生物利用度及有效的抗肿瘤活性。
TQ0013	BTTAA	Others	Others
	BTTAA 是 Cu(I)-稳定配体，能够的有效与泛素 Glu18AzF 反应。
T5938	4-Phenoxybenzylamine	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	4-Phenoxybenzylamine 通过稳定无活性构象来抑制NS3蛋白的功能，对 HCV NS3/4a 的 IC50 约为 500 μM。
T7409	360A 3,3'-[2,6-吡啶二基二(羰基亚氨基)]二[1-甲基喹啉鎓]	DNA/RNA Synthesis; Telomerase	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	360A 是一种稳定的G-四链体配体，还抑制 TRAP-G4 试验中端粒酶的端粒酶活性，IC50值为 300 nM。
T11147	EC5026 BPN-19186	Epoxide Hydrolase	Metabolism
	EC5026 (BPN-19186) 是首创的，非阿片类的，可溶性环氧水解酶 (sEH) 抑制剂，它可有效缓解发炎性和神经性疼痛。
T24239	K201 K-201,JTV 519,JTV-519,K 201	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	K201 (JTV-519) 是一种 Ca2+ 依赖性阻滞剂，通过稳定兰尼碱受体来防止缺血性心脏和骨骼肌 (SkM) 中的肌质网异常 Ca(2+) 泄漏。
T65287	MES monohydrate	Others	Others
	MES monohydrate 是一种两性离子缓冲液，是一种 PH 稳定试剂，可用于蛋白质纯化和酶测定。
T1170	Olopatadine hydrochloride 盐酸奥洛他定,Olopatadine HCl,KW4679,ALO4943A	5-HT Receptor; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Olopatadine hydrochloride (ALO4943A) 是一种抗组胺药，具有稳定肥大细胞的特性，用作治疗过敏性结膜炎的滴眼液。
T77516	SARS-CoV-2-IN-39	Antiviral; SARS-CoV	Immunology/Inflammation; Microbiology/Virology
	SARS-CoV-2-IN-39是一种 SARS-CoV-2 抑制剂，EC50 为 1 μM。 SARS-CoV-2-IN-39 具有抗病毒活性，通过抑制 SKP2 蛋白并稳定 BECN1 来抑制 SARS-CoV-2。
T9095	Necrostatin-34 2-{[3-cyano-4-(4-methylphenyl)-6-oxo-1,4	RIP kinase	Apoptosis; NF-κB
	Necrostatin-34 (2-{[3-cyano-4-(4-methylphenyl)-6-oxo-1,4) 是一种 RIPK1 激酶抑制剂，通过在激酶结构域中占据一个独特的结合口袋，将 RIPK1 激酶稳定在非活性构象中。
T13951	UCB-9260	TNF	Apoptosis
	UCB-9260 是口服活性小分子，通过稳定三聚体的不对称形式抑制肿瘤坏死因子信号传导。它对肿瘤坏死因子的选择性高于其他超家族成员，并与肿瘤坏死因子结合，其Kd 值为 13 nM。
T21470L	Davunetide acetate Davunetide acetate(211439-12-2 Free base)	Beta Amyloid; Microtubule Associated	Cytoskeletal Signaling; Neuroscience
	Davunetide acetate 源自哺乳动物 CNS 中存在的活性依赖性神经保护蛋白。 Davunetide acetate 是一种微管稳定肽，可抑制 Aβ 聚集和 Aβ 诱导的神经毒性。 Davunetide acetate 具有神经保护、神经营养和认知保护特性。
T26360	Benperidol R4584,R-4584,Anquil,McN-JR-4584,R 4584
	Benperidol (Anquil)是一种具有抗精神病和安定作用的丁酮类化合物，在阻断 D2 受体方面具有很好的疗效。Benperidol可用于正电子发射断层扫描(PET)测量体内 D(2)类多巴胺受体的结合情况。
T1320	Disopyramide Triombrin,Hypaque sodium,amidotrizoate sodium,达舒平	Potassium Channel; Sodium Channel; AChR	Membrane transporter/Ion channel; Neuroscience
	Disopyramide (Triombrin) 是用于研究房性和室性心律失常的 IA 类抗心律失常试剂。它阻断心肌快速内向钠电流，延长心肌动作电位持续时间。它抑制 HERG 编码的钾通道。它也表现出复杂的蛋白质结合，并具有强大的负性肌力作用。
T15713	Larotaxel XRP9881	P-gp	Membrane transporter/Ion channel; Neuroscience
	Larotaxel (XRP9881) 是一种紫杉烷类似物，具有抗癌活性，通过促进微管蛋白装配和稳定微管发挥其细胞毒性作用，并通过细胞凋亡诱导细胞死亡。Larotaxel (XRP9881) 是一种可穿过血脑屏障的化合物，对 Docetaxel 的亲和力比 P-糖蛋白 1 高，可用于研究乳腺癌和膀胱癌。
T0939	Phenytoin 苯妥英,Diphenylhydantoin,5,5-Diphenylhydantoin	Virus Protease; Sodium Channel	Membrane transporter/Ion channel; Microbiology/Virology
	Phenytoin (5,5-Diphenylhydantoin) 是一种有效的电压门控钠离子通道阻滞剂，可减少小鼠乳腺肿瘤的生长和转移，具有抗癫痫活性。
T1282	Carteolol hydrochloride Arteoptic,Abbott-43326,OPC-1085 hydrochloride,盐酸卡替洛尔,Carteolol HCl,Mikelan	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Carteolol hydrochloride (Abbott-43326) 是一种非选择性的β肾上腺素受体阻断剂。
T77520	AOH1996	Apoptosis; DNA/RNA Synthesis	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	AOH1996 是一种具有口服活性的复制体组分 PCNA (增殖细胞核抗原) 配体，靶向转录-复制冲突 (TRC)。AOH1996 可干扰 PCNA 与其结合蛋白的相互作用，导致 DNA 复制应激，诱导细胞凋亡 (apoptosis)。AOH1996 通过稳定 PCNA 和 RNA 聚合酶 II 的相互作用从而导致蛋白酶体依赖的 rpb1 降解和致命的 DNA 损伤。AOH1996 与 DNA 损伤剂具有协同作用，可抑制肿瘤细胞生长。
T14687	Deucravacitinib BMS-986165	Tyrosine Kinases; JAK; IFNAR; Interleukin	Angiogenesis; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
	Deucravacitinib (BMS-986165) 是一种高选择性、口服生物可利用的变构 TYK2 抑制剂，用于治疗自身免疫性疾病。它通过稳定调节 JH2 结构域来阻断受体介导的 Tyk2 激活，可抑制IL-12/23和 I 型IFN 途径。它选择性结合 TYK2 假激酶 (JH2) 结构域，IC50为1.0 nM。
T1012	Acebutolol hydrochloride 盐酸醋丁洛尔,Acebutolol HCl	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Acebutolol hydrochloride (Acebutolol HCl) 是一种 β-肾上腺素受体拮抗剂，用于研究高血压、心绞痛和心律失常。
T1602	Valproic acid sodium salt 丙戊酸钠,Sodium Valproate	Mitophagy; Gamma-secretase; HIV Protease; GABA Receptor; HDAC; Autophagy	Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience; Proteases/Proteasome; Stem Cells
	Valproic acid sodium salt (Sodium Valproate) 是一种HDAC 抑制剂，可抑制HDAC1的活性，诱导HDAC2的降解。它激活Notch1信号并抑制小细胞肺癌细胞的增殖。它可研究癫痫、偏头痛和双相情感障碍等。
T37807	JTV 519 fumarate
	Ryanodine receptor (RyR) inhibitor; stabilizes RyR2 in a closed conformation. Exhibits antiarrhythmic and cardioprotective properties in vivo. Hunt et al (2007) K201 (JTV519) suppresses spontaneous Ca2+ release and [3H]ryanodine binding to RyR2 irrespective of FKBP12.6 association. Biochem.J. 404 431 PMID:17313373 \|Chen et al (2008) Effect of K201, a novel antiarrhythmic drug on calcium handling and arrhythmogenic activity of pulmonary vein cardiomyocytes. Br.J.Pharmacol. 153 915 PMID:17994112 \|...
T35841	5-Benzyloxygramine	Dopamine Receptor; 5-HT Receptor	GPCR/G Protein; Neuroscience
	5-Benzyloxygramine 是一种 N 蛋白、蛋白互作的原位稳定剂，具有抗病毒和稳定 N-NTD 蛋白的作用。它能够阻断多巴胺受体，可拮抗 5-HT 对大鼠子宫和兔耳的作用。
T24788	Shield-2
	Shield-2 is a potent FKBP-derived destabilizing domain stabilizing ligand.
T32146	IMC-48 NSC 138948,NSC-138948,IMC48,NSC138948
	IMC-48, as a BCL2 i-motif-interactive compound, can act by stabilizing or facilitating the folding of the i-motif.
T17001	Tazanolast 他扎司特,Tazalest,TO 188,Tazanol	Others	Others
	Tazanolast is a selective mast-cell-stabilizing drug.
T35879	Octyl glucose neopentyl glycol
	Octyl glucose neopentyl glycol (OGNG) is a detergent derived from neopentyl glycol, intended for stabilizing membrane proteins [1].
T70983	Zoledronate disodium
	Zoledronate disodium is an inhibitor of osteoclastogenesis and macrophage recruitment, decreasing bone turnover and stabilizing the bone matrix, exhibiting diverse anti-tumor effects in osteosarcoma.
T70878	P516-0475
	P516-0475 is a novel chemical inducer of Streptococcus quorum sensing acts by inhibiting the pheromone-degrading endopeptidase PepO. This compound induces quorum sensing by stabilizing SHP pheromones in culture.
T27521	GX-936 GX 936,PF 05196233,PF05196233,GX936,PF-05196233
	GX-936, a Nav1.7 inhibitor, inhibits Nav1.7 through a voltage-sensor trapping mechanism, likely by stabilizing inactivated states of the channel.
T40558	Triclosan-methyl
	Triclosan-methyl is a derivative of triclosan, which functions as a bactericide in various personal care products including toothpaste, shampoos, and soaps. Additionally, triclosan serves as a stabilizing agent in numerous detergents and cosmetics.
T5450	DL-071-IT Afurolol Hydrochloride,DL 071 IT	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	DL-071-IT (Afurolol Hydrochloride) 是一种有效的非选择性β-肾上腺素受体拮抗剂。 DL-071-IT 表现出内在的拟交感神经活性和弱的膜稳定活性。
T76054	SAHM1 TFA
	SAHM1 TFA is a chemical compound that acts as a Notch pathway inhibitor by stabilizing a hydrocarbon-stapled alpha helical peptide. It specifically targets the protein-protein interface, effectively preventing the assembly of the Notch complex.
T38439	DC-Srci-6649
	DC-Srci-6649 is a potent and selective inhibitor of c-Src kinase, effectively blocking its phosphorylation and stabilizing it in an inactive conformation.
TP1977	187-1, N-WASP inhibitor
	Inhibits neural Wiskott-Aldrich syndrome protein (N-WASP) by stabilizing the autoinhibited state of the protein. Blocks phosphatidylinositol 4,5-bisphosphate (PIP2)-stimulated actin assembly (IC50 ~ 2 μM) but does not directly inhibit actin polymerization
T21191	Phosphonic acid, P-decyl- 1-Decanephosphonic acid,Decanephosphonic acid,Decylphosphonic acid
	Phosphonic acid, P-decyl- is used as an important raw material and intermediate in organic synthesis, agrochemicals, dyestuff, and pharmaceuticals. It is also used in stabilizing dye-sensitized solar cells.
T67809	simotaxel
	Simotaxel 是一种半合成的、口服生物可利用的第三代紫杉烷衍生物和微管稳定剂，具有潜在的抗肿瘤活性。
T31530	Disoxaril BRN 3626820,WIN51711,WIN-51711,BRN-3626820,WIN 51711,WIN-51,711
	Disoxaril (BRN 3626820, WIN 51711) is an anti-picornavirus agent that inhibits enterovirus replication by binding to a hydrophobic bag within the VP1 coat protein, thereby stabilizing virions and preventing their uncoating. When used in combination with A
T37063	Laulimalide
	Microtubule stabilizing agent. Potent inhibitor of cellular proliferation in cancer cell lines (IC50 reported to be 3-30 nM, dependent on cell line used). Causes cells to arrest in the prometaphase of the cell cycle, prevents formation of bipolar spindle and increases kinetochore tension in preformed spindles. Pryor et al (2002) The microtubule stabilizing agent laulimalide does not bind in the taxoid site, kills cells resistant to PacT. and epothilones, and may not require its epoxide moiety fo...
T69880	YW2065
	YW2065 has excellent anti-colorectal cancer effects in vitro and in vivo. YW2065 achieves its inhibitory activity for Wnt signaling by stabilizing Axin-1, a scaffolding protein that regulates proteasome degradation of β-catenin. Simultaneously, YW2065 also led to the activation of the tumor suppressor AMPK, providing an additional anticancer mechanism. In addition, YW2065 showed favorable pharmacokinetic properties without obvious toxicity.
T38828	Mesdopetam IRL790
	Mesdopetam (IRL790) is a dopamine D3 receptor antagonist with a Ki of 90 nM and an IC50 of 9.8 μM for the human recombinant D3 receptor. It exhibits psychomotor stabilizing properties and is utilized in the study of motor and psychiatric complications associated with Parkinson's disease.
T71785	GUN35758
	GUN35758, also known as 4'-Carboxybenzo-18C6, is a novel transthyretin (ttr) amyloidogenesis inhibitor, stabilizing the ttr tetramer by binding to the allosteric sites on the molecular surface of the ttr tetramer. This product has no formal name at the moment. For the convenience of communication, a temporary code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming).
T74961	Anticancer agent 84
	Anticancer agent 84 是抗癌剂。Anticancer agent 84 通过稳定 G-四链体 (G4) 结构来抑制c-MYC 的转录。Anticancer agent 84 可用于癌症研究。
T36485	Becatecarin
	Becatecarin is a water-soluble, diethylaminoethyl analog of the antineoplastic antibiotic rebeccamycin. It intercalates into DNA, stabilizing the DNA-topoisomerase complex. This results in the potent catalytic inhibition of both topoisomerases I and II, initiating DNA cleavage and apoptosis. Becatecarin, alone or in combination with other compounds, has anti-cancer as well as myelosuppressive effects in vivo. It is also a transport substrate of the ATP-binding cassette (ABC) transporter ABCG2.
T37846	Taurohyocholic Acid (sodium salt)
	Taurohyocholic acid (THCA) is a taurine-conjugated form of the porcine-specific primary bile acid hyocholic acid .1THCA inhibits precipitation of cholesterol crystals by stabilizing cholesterol in the liquid-crystalline phase.2It prevents cholestasis and cellular necrosis induced by taurolithocholic acid in isolated rat livers.3THCA levels are increased in the urine of patients with hepatitis B-induced cirrhosis.4
T73674	Poly (I:C):Kanamycin (1:1)
	Poly (I:C):Kanamycin (1:1) 是一种 Poly (I:C) 与卡那霉素 (kanamycin) 以 1:1 比例混合得到的化合物。Poly (I:C) 为双链 RNA 的合成模拟物，充当 TLR3 受体的激动剂，而卡那霉素则能够增强 Poly (I:C) 的稳定性。
T72201	Pyridostatin hydrochloride RR82 hydrochloride
	Pyridostatin (RR82) hydrochloride 是一种高选择性的 G-quadruplexDNA 稳定剂 (Kd=490 nM)。Pyridostatin hydrochloride 通过诱导复制和转录依赖的 DNA 损伤促进人类癌细胞生长停滞。Pyridostatin hydrochloride 靶向原癌基因 Src。Pyridostatin hydrochloride 降低人乳腺癌细胞 SRC 蛋白水平和 SRC 依赖的细胞运动。

化合物

Microtubule stabilizing agent-1

Cat.No: T79508

Cat.No: T7806

Synonym: 10,11-hydroxy-10,11 Dihydrocarbamezer,10,11-二氢-10-羟基卡马西平

Target: Others

Mesdopetam hemitartrate

Cat.No: T9409

Synonym: IRL790 hemitartrate,1-Propanamine, N-[2-[3-fluoro-5-(methylsulfonyl)phenoxy]ethyl]-, (2R,3R)-2,3-dihydroxybutanedioate (2:1)

Target: Dopamine Receptor

Microtubule destabilizing agent-1

Cat.No: T74166

Cat.No: TQ0013

Target: Others

4-Phenoxybenzylamine

Cat.No: T5938

Target: HCV Protease

Cat.No: T7409

Synonym: 3,3'-[2,6-吡啶二基二(羰基亚氨基)]二[1-甲基喹啉鎓]

Target: DNA/RNA Synthesis, Telomerase

Cat.No: T11147

Synonym: BPN-19186

Target: Epoxide Hydrolase

Cat.No: T24239

Synonym: K-201,JTV 519,JTV-519,K 201

Target: Calcium Channel

MES monohydrate

Cat.No: T65287

Target: Others

Olopatadine hydrochloride

Cat.No: T1170

Synonym: 盐酸奥洛他定,Olopatadine HCl,KW4679,ALO4943A

Target: 5-HT Receptor, Histamine Receptor

SARS-CoV-2-IN-39

Cat.No: T77516

Target: Antiviral, SARS-CoV

Cat.No: T9095

Synonym: 2-{[3-cyano-4-(4-methylphenyl)-6-oxo-1,4

Target: RIP kinase

Cat.No: T13951

Target: TNF

Davunetide acetate

Cat.No: T21470L

Synonym: Davunetide acetate(211439-12-2 Free base)

Target: Beta Amyloid, Microtubule Associated

Cat.No: T26360

Synonym: R4584,R-4584,Anquil,McN-JR-4584,R 4584

Cat.No: T1320

Synonym: Triombrin,Hypaque sodium,amidotrizoate sodium,达舒平

Target: Potassium Channel, Sodium Channel, AChR

Cat.No: T15713

Synonym: XRP9881

Target: P-gp

Cat.No: T0939

Synonym: 苯妥英,Diphenylhydantoin,5,5-Diphenylhydantoin

Target: Virus Protease, Sodium Channel

Carteolol hydrochloride

Cat.No: T1282

Synonym: Arteoptic,Abbott-43326,OPC-1085 hydrochloride,盐酸卡替洛尔,Carteolol HCl,Mikelan

Target: Adrenergic Receptor

Cat.No: T77520

Target: Apoptosis, DNA/RNA Synthesis

Deucravacitinib

Cat.No: T14687

Synonym: BMS-986165

Target: Tyrosine Kinases, JAK, IFNAR, Interleukin

Acebutolol hydrochloride

Cat.No: T1012

Synonym: 盐酸醋丁洛尔,Acebutolol HCl

Target: Adrenergic Receptor

Valproic acid sodium salt

Cat.No: T1602

Synonym: 丙戊酸钠,Sodium Valproate

Target: Mitophagy, Gamma-secretase, HIV Protease, GABA Receptor, HDAC, Autophagy

JTV 519 fumarate

Cat.No: T37807

5-Benzyloxygramine

Cat.No: T35841

Target: Dopamine Receptor, 5-HT Receptor

Cat.No: T24788

Cat.No: T32146

Synonym: NSC 138948,NSC-138948,IMC48,NSC138948

Cat.No: T17001

Synonym: 他扎司特,Tazalest,TO 188,Tazanol

Target: Others

Octyl glucose neopentyl glycol

Cat.No: T35879

Zoledronate disodium

Cat.No: T70983

Cat.No: T70878

Cat.No: T27521

Synonym: GX 936,PF 05196233,PF05196233,GX936,PF-05196233

Triclosan-methyl

Cat.No: T40558

Cat.No: T5450

Synonym: Afurolol Hydrochloride,DL 071 IT

Target: Adrenergic Receptor

Cat.No: T76054

Cat.No: T38439

187-1, N-WASP inhibitor

Cat.No: TP1977

Phosphonic acid, P-decyl-

Cat.No: T21191

Synonym: 1-Decanephosphonic acid,Decanephosphonic acid,Decylphosphonic acid

Cat.No: T67809

Cat.No: T31530

Synonym: BRN 3626820,WIN51711,WIN-51711,BRN-3626820,WIN 51711,WIN-51,711

Cat.No: T37063

Cat.No: T69880

Cat.No: T38828

Synonym: IRL790

Cat.No: T71785

Anticancer agent 84

Cat.No: T74961

Cat.No: T36485

Taurohyocholic Acid (sodium salt)

Cat.No: T37846

Poly (I:C):Kanamycin (1:1)

Cat.No: T73674

Pyridostatin hydrochloride

Cat.No: T72201

Synonym: RR82 hydrochloride

Cat. No.	Product Name	Target	Signaling Pathways
T7964	Isomalt 异麦芽酮糖醇,Palatinitol,Palatinit	Others; Dehydrogenase	Metabolism; Others
	Isomalt (Palatinitol) 是无毒的、具有良好耐受性的多元醇和蛋白质稳定的赋形剂，在冷冻干燥过程中可适度稳定乳酸脱氢酶(LDH)，并在储存期间表现更好。它传统上在食品工业中用作甜味剂，也在制药中用作压片赋形剂。
T3253	Castor oil Ricinus Oil,蓖麻油,Xenaderm,Venelex	Others	Others
	Castor oil (Xenaderm) 是天然甘油三酯和溶剂。它可用作形成聚合物-纳米颗粒复合材料的溶剂、助溶剂、稳定剂和多元醇。它具有缓泻作用，可诱导怀孕女性分娩。
T6490	Epothilone A 埃博霉素 A,epothile,Epo A	Apoptosis; Microtubule Associated	Apoptosis; Cytoskeletal Signaling
	Epothilone A (Epo A) 是紫杉醇和管蛋白聚合物结合的一种竞争性抑制剂，其Ki 值为 0.6-1.4 μM。
T16674	Pseudouridine	Endogenous Metabolite	Metabolism
	Pseudouridine 是非编码 RNA 中丰富的修饰核苷，通过稳定 RNA 结构增强核糖体 RNA 和的转移 RNA 功能。
T5S1989	Apiin Apioside,芹菜苷	Others	Others
	Apiin (Apioside) 是Apium graveolens 叶片的一种主要成分，具有抗炎作用。它在体外抑制亚硝酸盐产生的IC50值为0.08 mg/mL，在 LPS 激活的 J774.A1 细胞中抑制 iNOS 的表达的IC50值为0.049 mg/ mL。
TWO2759	Thymine 胸腺嘧啶,5-methyluracil	Others; Endogenous Metabolite	Metabolism; Others
	Thymine (5-methyluracil) 是 DNA 的四个碱基之一，在动物癌症模型中，能够作为5-氟尿嘧啶的靶标，其 Km=2.3 μM。
T0486L	Irinotecan Hydrochloride 盐酸伊立替康,伊立替康盐酸盐,Camptothecin 11 hydrochloride,CPT-11 hydrochloride	Topoisomerase; Autophagy	Autophagy; DNA Damage/DNA Repair
	Irinotecan Hydrochloride (CPT-11 hydrochloride) 是喜树碱半合成衍生物的盐酸盐，是一种拓扑异构酶 I 抑制剂，可研究结肠癌和直肠癌。
TN2254	Taccalonolide A 根薯酮内酯A,根薯酮内酯 A	Apoptosis; Microtubule Associated	Apoptosis; Cytoskeletal Signaling
	Taccalonolide A 是从水田七根茎中分离得到的一种类固醇，具有细胞毒性和抗疟活性。它在体外对过表达 p 糖蛋白、多药耐药蛋白 7 细胞系有抑制作用，抑制 SK-OV-3 细胞生长的 IC50值为 622 nM。它是微管稳定剂，能引起 G2-M 期滞留、Bcl-2 磷酸化，并引发细胞凋亡。
T21027	Guar gum Guaran,Gum cyamopsis,Gum guar,Guar flour
	Guar gum is a galactomannan polysaccharide extracted from guar beans, it has stabilizing and thickening properties useful in food, feed, and industrial applications.
T10763	Ceratamine A	Others	Others
	Ceratamine A is an antimitotic heterocyclic alkaloid isolated from the marine sponge Pseudoceratina sp., acts as a microtubule-stabilizing agent with cytotoxicity against human cancer cell lines.
T28122	Myrtenal NSC-54384,NSC 54384,NSC54384,Benihinal
	Myrtenal is a natural monoterpene. It is found to attenuate diethylnitrosamine-induced hepatocellular carcinoma in rats by stabilizing intrinsic antioxidants and modulating apoptotic and anti-apoptotic cascades. Myrtenal also inhibits acetylcholinesterase
TN3931	ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid	ERK; BCL; p38 MAPK; NF-κB; Caspase; JNK; p53	Apoptosis; MAPK; NF-κB; Proteases/Proteasome
	Ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid has anti-cancer activity, it induces apoptosis of human malignant cancer cells, it also inhibits hepatocellular carcinoma in vitro and in vivo via stabilizing IkBα.
T72964	Dictyostatin Dictyostatin 1,(-)-Dictyostatin ; Dictyostatin 1,(-)-Dictyostatin
	Dictyostatin ((-)-Dictyostatin ; Dictyostatin 1) 是一种有效的微管稳定剂。 Dictyostatin 也是一种抗癌剂。 Dictyostatin 具有抗增殖活性。Dictyostatin 具有研究 tauopathies 的潜力。
T83405	2,3-Diphosphoglyceric acid 2,3-DPG
	2,3-Diphosphoglyceric acid (2,3-DPG) 是一种糖酵解途径的中间产物，能够通过变构作用结合并稳定脱氧血红蛋白，从而促进氧气在组织部位的释放。此外，2,3-Diphosphoglyceric acid 与血红蛋白结合，有效降低了其对氧的亲和力。
T73402	Flavipin
	Flavipin 是一种芳香烃受体(Ahr)激动剂，可诱导小鼠 CD4+T 细胞和 CD11b+巨噬细胞表达 Ahr 下游基因。Flavipin 抑制 Arid5a 在 Il23a3'UTR 上的稳定功能，这是一种新发现的靶 mRNA。Flavipin 具有清除 DPPH 自由基的能力，IC50值为7.2 μM，对α-葡萄糖苷酶具有较强的抑制作用，IC50值为 33.8 μM。

天然产物

Cat.No: T7964

Synonym: 异麦芽酮糖醇,Palatinitol,Palatinit

Target: Others, Dehydrogenase

Cat.No: T3253

Synonym: Ricinus Oil,蓖麻油,Xenaderm,Venelex

Target: Others

Cat.No: T6490

Synonym: 埃博霉素 A,epothile,Epo A

Target: Apoptosis, Microtubule Associated

Cat.No: T16674

Target: Endogenous Metabolite

Cat.No: T5S1989

Synonym: Apioside,芹菜苷

Target: Others

Cat.No: TWO2759

Synonym: 胸腺嘧啶,5-methyluracil

Target: Others, Endogenous Metabolite

Irinotecan Hydrochloride

Cat.No: T0486L

Synonym: 盐酸伊立替康,伊立替康盐酸盐,Camptothecin 11 hydrochloride,CPT-11 hydrochloride

Target: Topoisomerase, Autophagy

Taccalonolide A

Cat.No: TN2254

Synonym: 根薯酮内酯A,根薯酮内酯 A

Target: Apoptosis, Microtubule Associated

Cat.No: T21027

Synonym: Guaran,Gum cyamopsis,Gum guar,Guar flour

Cat.No: T10763

Target: Others

Cat.No: T28122

Synonym: NSC-54384,NSC 54384,NSC54384,Benihinal

ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid

Cat.No: TN3931

Target: ERK, BCL, p38 MAPK, NF-κB, Caspase, JNK, p53

Cat.No: T72964

Synonym: Dictyostatin 1,(-)-Dictyostatin ; Dictyostatin 1,(-)-Dictyostatin

2,3-Diphosphoglyceric acid

Cat.No: T83405

Synonym: 2,3-DPG

Cat.No: T73402

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼