首页工具

登录

搜索结果

Search Results for " pro-inflammatory cytokines "

43

抑制剂 & 化合物

23

天然产物

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
T21729	(±)-Lisofylline	Others	Others
	(±)-Lisofylline 是一种对映异构体特异性、烷基取代的甲基黄嘌呤，在下调白细胞活化方面具有特异性和有效的活性。它是一种抗炎剂。
T38361	GSK717	IL Receptor; NOD	Immunology/Inflammation; NF-κB
	GSK717 是 NOD2(核苷酸结合寡聚结构域 2) 的选择性抑制剂。它抑制壁酰二肽 (MDP) 诱导的 NOD2 介导的信号转导，抑制 MDP 刺激的 HEK293/hNOD2 细胞分泌 IL-8 (IC50为 400 nM)。
T38423	CL097 CL097	Reactive Oxygen Species; TLR	Immunology/Inflammation; Metabolism; NF-κB
	CL097 是 TLR7 和 TLR8 的有效激动剂。 CL097 诱导巨噬细胞中的促炎细胞因子和 NADPH 氧化酶引发，从而增加 fMLF 刺激的 ROS 产生。
T20763	Betamethasone disodium phosphate Vista-Methasone,NSC90616,Betamethasone 21-phosphate disodium salt,NSC-90616	Others	Others
	Betamethasone disodium phosphate (Betamethasone 21-phosphate disodium salt) 是一种具有抗炎活性的皮质类固醇，通过减少促炎细胞因子的分泌促进 M1 至 M2 巨噬细胞极化，可用于研究瘢痕疙瘩和类风湿性关节炎。
T7872	Monolaurin	Others	Others
	Monolaurin 是椰子油中的一种表面活性剂和乳化剂。它抑制葡萄球菌、链球菌、加德纳菌、念珠菌和嗜血杆菌的生长，并减少促炎细胞因子的产生。
T0468	Lidocaine Lignocaine,Alphacaine,Xylocaine,利多卡因	Apoptosis; ERK; NF-κB; MEK; Sodium Channel; Histamine Receptor	Apoptosis; GPCR/G Protein; Immunology/Inflammation; MAPK; Membrane transporter/Ion channel; Neuroscience; NF-κB
	Lidocaine (Alphacaine) 是一种酰胺衍生物，抑制涉及复杂电压和依赖性的钠通道，可用于研究室性心律失常。它通过调节 miR-145 表达和进一步抑制 MEK/ERK 和 NF-κB 信号通路来减少胃癌细胞的生长，迁移和侵袭。
T67896	CB2R/FAAH modulator-1	Cannabinoid Receptor; FAAH	GPCR/G Protein; Metabolism; Neuroscience
	CB2R/FAAH modulator-1是一种大麻素2型受体(CB2R)激动剂，同时也是脂肪酸酰胺水解酶(FAAH)抑制剂（IC50=4 μM），可减少促炎和增加抗炎细胞因子的产生，常用于炎症研究。对 CB2R 和 CB1R 的Kis 分别为14.8 nM 和241.3 nM。
T67924	ABzOH
	ABzOH 是一种苯甲酸衍生物，结构类似于阿司匹林等非甾体抗炎药，具有抗炎、抗肿瘤和抗增殖作用。ABzOH 不仅可以抑制肿瘤坏死因子- α (TNF-a)、白细胞介素-1β (IL-1β)和白细胞介素-6 (IL-6)等促炎细胞因子的表达还对乳腺癌、肺癌和胰腺癌具有抑制作用。
T76781	Itolizumab EQ-001	Others	Others
	Itolizumab (Anti-Human CD6 Recombinant Antibody) 是一种人源化针对 CD6 的细胞外 SRCR 远端结构域 1的重组抗 CD6 单克隆抗体。Itolizumab 可减缓 T 细胞增殖并抑制促炎细胞因子的产生。Itolizumab 可用于研究银屑病、类风湿性关节炎 (RA)和 COVID-19 疾病等多种疾病。
T61025	GSK-1482160	P2X Receptor	Membrane transporter/Ion channel; Neuroscience
	GSK-1482160是一种CNS-渗透的P2X7受体负变构调节剂，具有口服活性。P2X7受体参与中枢和外周免疫细胞产生促炎细胞因子，因此GSK-1482160具有研究炎症性疾病的潜力。GSK-1482160具有出色的体外效价(在包括人类在内的多种物种的重组和初始P2X7受体的功能和电生理测试中)和交叉靶标选择性。
T2548	Diflorasone	Glucocorticoid Receptor	Endocrinology/Hormones
	Diflorasone 是一种皮质类固醇激素受体激动剂，具有抗炎和免疫抑制作用。它可通过细胞膜扩散进入细胞，并与细胞质中的糖皮质激素受体结合。它用于研究湿疹、牛皮癣等皮肤病。
T30831	Cgp 43182 Cgp-43182,Cgp43182
	CGP 43182 is an effective inhibitor of group IIA secretory phospholipase A2 (Group IIA sPLA2) activity in vitro, which can be used to prevent the synergistic effect of pro-inflammatory genes stimulated by cytokines mediated by NFkappaB.
T70367	SNU-BP
	SNU-BP is an agonist of PPAR-gamma, inhibiting lipopolysaccharide (LPS)-induced NO production and pro-inflammatory cytokines. SNU-BP potentiates interleukin-4-induced arginase-1 expression, and promotes microglial polarization toward an M2 anti-inflammatory phenotype.
T41086	IDR-1
	IDR-1 is an antimicrobial peptide with activity against both Gram-positive and Gram-negative bacteria. This compound modulates innate immunity to counter infections while avoiding evident toxicities. Additionally, IDR-1 exhibits anti-inflammatory and anti-infective properties, increases the levels of monocyte chemokines, and reduces the release of pro-inflammatory cytokines.
T26776	Berteroin OR-009512,KB-47947,LP-088984,KB47947,LP088984
	Berteroin is an erucin homolog and potential antioxidant. It is present in cruciferous vegetables, including rucola salad leaves, Chinese cabbage and mustard oil. It decreases the release of pro-inflammatory cytokines in LPS-stimulated macrophages. It als
T11357	Gamma-glutamylcysteine TFA γ-glutamylcysteine (TFA),Gamma-glutamylcysteine (TFA)	IL Receptor	Immunology/Inflammation
	Gamma-glutamylcysteine (TFA) also upregulates the level of the anti-inflammatory cytokine IL-10 and reduces the levels of the pro-inflammatory cytokines (TNF-α, IL-6, and IL-1β) and attenuates the changes in metalloproteinase activity in oligomeric Aβ40-treated astrocytes. Gamma-glutamylcysteine (TFA) ((γ-glutamylcysteine (TFA)), an intermediate in glutathione (GSH) synthesis, is a dipeptide served as an essential cofactor for the antioxidant enzyme glutathione peroxidase (GPx).
TP2035	FSL-1 FSL 1
	TLR2/6 agonist (also a putative TLR10 ligand). Activates NF-κB. Induces pro-inflammatory cytokines including IL-8, IL-1β, CCL20 and TNF-α in vitro. Synergizes with IFNγ to induce CXCL10 release from melanoma cells.
T60517	CL097 hydrochloride
	CL097 hydrochloride 是一种有效的 TLR7和 TLR8激动剂。CL097 hydrochloride 可在巨噬细胞中诱导促炎细胞因子和 NADPH 氧化酶启动活性，从而增加 fMLF 刺激的ROS 产生。
T78782	PROTAC BTK Degrader-6	BTK	Angiogenesis; Tyrosine Kinase/Adaptors
	PROTACBTK Degrader-6 (Compound 15) 为PROTACBTK类降解剂，其DC50为3.18 nM。该化合物展现出抗炎特性，能够抑制NF-κB的激活，并降低促炎细胞因子（如IL-1β、IL-6）的表达。
T30511	BMS-279700
	BMS-279700 is a potent oral activity inhibitor that is part of a new family of aniline 5-azimidazolaquoxaline analogs and has excellent anti-inflammatory activity in vivo, as well as in vitro activity against p56LCK and T cell proliferation, blocking the
T73424	GA-O-06
	GA-O-06是一种18β-Glycyrrhetinic acid衍生物，有效的抗菌及抗炎剂。它通过抑制NO、促炎细胞因子以及趋化因子来发挥抗炎效果，并对革兰氏阳性菌展现出高度的抗菌活性。
T73423	GA-O-02
	GA-O-02，一种18β-Glycyrrhetinic acid衍生物，具有显著的抗菌和抗炎效果。该化合物通过抑制NO、促炎细胞因子及趋化因子来发挥其抗炎作用，并对革兰氏阳性菌显示出高度的抗菌活性。
T79362	COX-2/15-LOX-IN-4	Lipoxygenase	Metabolism
	COX-2/15-LOX-IN-4（compound 5i）是一种针对COX-2和15-LOX的双重抑制剂，其IC50值分别为0.075 μM和1.97 μM。该化合物能有效地阻止LPS诱发的细胞内促炎细胞因子（IL-6, ROS）的产生，表现出明确的抗炎活性。
T38047	Maresin 1	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Maresin 1 是由巨噬细胞 (MΦ) 生物合成的小分子化合物，具有显著的抗炎活性，可通过抑制中性粒细胞粘附和降低促炎细胞因子水平来减轻LPS诱导的小鼠肺损伤，可以刺激胞内 Ca2+ 产生和分泌。
T68182	3-Hydroxykynurenamine
	3-Hydroxykynurenamine, also known as 3-Hydroxy-L-kynurenamine or 3-HKA, is a biogenic amine produced via an alternative pathway of tryptophan metabolism. In vitro, 3-HKA has an anti-inflammatory profile by inhibiting the IFN-γ mediated STAT1/NF-κΒ pathway in both mouse and human dendritic cells (DCs) with a consequent decrease in the release of pro-inflammatory chemokines and cytokines, most notably TNF, IL-6, and IL12p70. 3-HKA has protective effects in an experimental mouse model of psoriasis ...
T72849	CB2R agonist 1
	CB2R agonist 1 是一种大麻素受体亚型 2 (CB2R) 的选择性配体，EC50值为 0.56 µM。CB2R agonist 1 对人CB2R 和CB1R 分别具有高亲和力及优异选择性。CB2R agonist 1 调节促炎细胞因子和抗炎细胞因子的产生，发挥免疫调节作用。
T73326	CB2R-IN-3
	CB2R-IN-3 是大麻素 2 型受体 (CB2R) 的一种选择性拮抗剂。CB2R-IN-3 对人 CB2R 具有高亲和力，对 CB1R 具有特异选择性。CB2R-IN-3 可与 CB2R 的激活剂 CB65 联用。CB2R-IN-3 有效上调抗炎细胞因子的表达，下调促炎细胞因子的表达。
T79361	COX-2/15-LOX-IN-3	Lipoxygenase	Metabolism
	COX-2/15-LOX-IN-3 (compound 5k) 为COX-2/15-LOX的一种双重抑制剂，具有分别为0.075 μM和1.97 μM的IC50值。该化合物能显著抑制LPS诱导的细胞产生促炎细胞因子（IL-6, ROS和NO），表明其具备显著的抗炎活性。
T62640	FPR2 agonist 2
	FPR2 agonist 2 是一种具有血脑屏障通透性的、有效的 FPR2 激动剂 (EC50: 0.13 nM)。FPR2 agonist 2 对促炎细胞因子的产生和 caspase-3 的活性具有抑制作用，抵消线粒体功能的变化。
TP2195	Nitric Oxide Synthase (599-613) Blocking Peptide, Bovine Endothelial Cell	Others	Others
	Nitric Oxide Synthase (599-613) Blocking Peptide, Bovine Endothelial Cell (Ac-Pro-Tyr-Asn-Ser-Ser-Pro-Arg-Pro-Glu-Gln-His-Lys-Ser-Tyr-Lys-Cys) is a peptide that inhibits the function of NOSs as a result it blocks the production of NO. Because of the invol
T82233	HCAR2 agonist 1
	HCAR2 agonist 1 (Compound 9n) 是一种偏向Gi蛋白的变构调节剂，能够激活Gi蛋白相关的信号传导通路。该化合物展现了明显的抗炎效果，能够显著降低促炎细胞因子（TNF-α、IL-1β、IL-6 和 MCP-1）的mRNA表达水平，并在结肠炎小鼠模型中增强正位激动剂的抗炎作用。
T64017	RORγt agonist 3
	RORγt agonist 3 是 RORγt 的有效激动剂。RORγt agonist 3 能够促使 Th17 细胞分化，增加促炎细胞因子水平，进而提高淋巴细胞的细胞毒性。RORγt agonist 3 能够阻碍调节性 T 细胞的产生，并免疫反应产生抑制作用。
T64140	RORγt agonist 2
	RORγt agonist 2 是 RORγt 的有效的激动剂。RORγt agonist 2 能够诱导 Th17 细胞分化，增加促炎细胞因子水平，进而增强淋巴细胞的细胞毒性。RORγt agonist 2 对调节性 T 细胞的产生表现出抑制作用，能够抑制免疫反应。
T80469	Citrullinated LL-37 1cit
	Citrullinated LL-37 1cit 是一种Citrullinated形式的 LL-37 肽，保持了针对 human rhinovirus 的抗病毒 (antiviral) 功能，同时对S. aureus 表现出抗菌 (antibacterial) 活性。此外，Citrullinated LL-37 1cit 能够降低 RV1B 诱导的 IL-8、CCL5 和 IL-6mRNA 水平。
T79619	Anti-inflammatory agent 54
	Anti-inflammatory agent 54 (compound 9c)，作为薏苡醇 (Coixol) 的衍生物，显示出显著的抗炎效果。它通过抑制NF-κB通路，降低iNOS、TNF-α、IL-6和IL-1β的表达，进而在LPS诱导的RAW264.7巨噬细胞中降低一氧化氮 (NO) 生成（IC50: 2.4 μM）。此外，该化合物在小鼠耳廓水肿模型中表现出了体内抗炎活性。
T65390	Fluvoxketone
	Fluvoxketone is trifluoromethyl-substituted aryl ketone compound useful as an intermediate in the synthesis of Fluvoxamine, which is a selective serotonin reuptake inhibitor. In the synthesis of Fluvoxamine, the ketone carbonyl of Fluvoxketone is elaborated to an oxime.In vitro，the inhibitory effect of fluvoxamine on actin polymerization was concentration dependent, and its IC50 was approximately 30 μM.In vivo，fluvoxamine treated EAE rats showed a decrease in IFN-γ serum levels and an increase i...
T77089	Mirococept
	Mirococept (APT070) 是一种抗体，靶向补体系统 (complement system) 的 C3b/C4b，也是一种膜定位的 C3转化酶抑制剂。Mirococept 减少 C 肽和促炎细胞因子的释放，并减少炎症细胞的浸润。Mirococept 减少胰岛内炎症，有利于胰岛移植。Mirococept 还抑制增加的肠和肺血管通透性以减少中性粒细胞流入。
T78698	Aβ-IN-6
	Aβ-IN-6降低小胶质细胞释放的促炎细胞因子，能有效促进Nrf2核转位并抑制Aβ寡聚体的形成。通过调节体内氧化应激的氧化还原敏感信号通路，Aβ-IN-6展现出一致的神经保护效应。具有口服活性的Aβ-IN-6表现出抗炎、抗氧化和抗寡聚特性，并显示出作为阿尔茨海默病(AD)治疗研究潜力。
T80470	Citrullinated LL-37 2cit
	Citrullinated LL-37 2cit是瓜氨酸化的LL-37肽，在10 μg/mL浓度下可减弱LL-37对HRV活性的抑制，并降低LL-37的抗菌效果。此外，Citrullinated LL-37 2cit能显著降低RV1B诱导的IL-8、CCL5和IL-6 mRNA水平，并对HRV诱导的CCL5分泌能力有中度抑制作用。
T81423	Polzastobart JTX 8064
	Polzastobart (JTX-8064) 为一种人源化IgG4单克隆抗体，特异性与LILRB2结合，阻断其与配体及MHC I分子（经典与非经典）的相互作用。此抗体通过抑制LILRB2与HLA-A/B和/或HLA-G（癌细胞免疫耐受的标志）的结合，可增强巨噬细胞产生促炎细胞因子。Polzastobart 作为巨噬细胞免疫检查点抑制剂发挥作用。
T38394L	PSMα3 acetate(1001405-52-2 Free base)
	PSMα3 acetate(1001405-52-2 Free base) 是一种肽化合物，可用于诱导树突状细胞 (DC) 对 DC 疫苗接种策略的耐受性。PSMα3 acetate 通过改变 TLR2 或 TLR4 诱导的成熟过程，有效渗透和调节人类单核细胞衍生的 DC。此外，PSMα3 acetate 可抑制促炎细胞因子和抗炎细胞因子的产生，并减少抗原摄取。 PSMα3 acetate 是大多数致病性耐甲氧西林金黄色葡萄球菌 (MRSA) 菌株释放的重要毒力因子。
T36401	DCVC
	DCVC inhibits pathogen-stimulated TNF-α in human extra placental membranes in vitro.Target: TNF-αin vitro: DCVC inhibits pathogen stimulated cytokine release from tissue punch cultures. DCVC (5-50 μM) significantly inhibits LTA-, LPS-, and GBS-stimulated cytokine release from tissue cultures as early as 4 h (P ≤ 0.05). In contrast, TCA (up to 500 μM) does not inhibit LTA-stimulated cytokine release from tissue punches. DCVC effects on LTA-stimulated and LPS-stimulated TNF-α release from tissue p...
T36629	Givinostat
	Givinostat (ITF-2357) is a HDAC inhibitor with an IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively. Givinostat (ITF2357) suppresses total LPS-induced IL-1β production robustly compared with the reduction by ITF3056. At 25, 50, and 100 nM, Givinostat reduced IL-1β secretion more than 70%. Givinostat (ITF-2357) suppresses the production of IL-6 in PBMCs stimulated with TLR agonists as well as the combination of IL-12 plus IL-18. IL-6 secretion decreases to 50% at 50 nM Givinostat, but at 1...

化合物

(±)-Lisofylline

Cat.No: T21729

Target: Others

Cat.No: T38361

Target: IL Receptor, NOD

Cat.No: T38423

Synonym: CL097

Target: Reactive Oxygen Species, TLR

Betamethasone disodium phosphate

Cat.No: T20763

Synonym: Vista-Methasone,NSC90616,Betamethasone 21-phosphate disodium salt,NSC-90616

Target: Others

Cat.No: T7872

Target: Others

Cat.No: T0468

Synonym: Lignocaine,Alphacaine,Xylocaine,利多卡因

Target: Apoptosis, ERK, NF-κB, MEK, Sodium Channel, Histamine Receptor

CB2R/FAAH modulator-1

Cat.No: T67896

Target: Cannabinoid Receptor, FAAH

Cat.No: T67924

Cat.No: T76781

Synonym: EQ-001

Target: Others

Cat.No: T61025

Target: P2X Receptor

Cat.No: T2548

Target: Glucocorticoid Receptor

Cat.No: T30831

Synonym: Cgp-43182,Cgp43182

Cat.No: T70367

Cat.No: T41086

Cat.No: T26776

Synonym: OR-009512,KB-47947,LP-088984,KB47947,LP088984

Gamma-glutamylcysteine TFA

Cat.No: T11357

Synonym: γ-glutamylcysteine (TFA),Gamma-glutamylcysteine (TFA)

Target: IL Receptor

Cat.No: TP2035

Synonym: FSL 1

CL097 hydrochloride

Cat.No: T60517

PROTAC BTK Degrader-6

Cat.No: T78782

Target: BTK

Cat.No: T30511

Cat.No: T73424

Cat.No: T73423

COX-2/15-LOX-IN-4

Cat.No: T79362

Target: Lipoxygenase

Cat.No: T38047

Target: Calcium Channel

3-Hydroxykynurenamine

Cat.No: T68182

Cat.No: T72849

Cat.No: T73326

COX-2/15-LOX-IN-3

Cat.No: T79361

Target: Lipoxygenase

Cat.No: T62640

Nitric Oxide Synthase (599-613) Blocking Peptide, Bovine Endothelial Cell

Cat.No: TP2195

Target: Others

HCAR2 agonist 1

Cat.No: T82233

RORγt agonist 3

Cat.No: T64017

RORγt agonist 2

Cat.No: T64140

Citrullinated LL-37 1cit

Cat.No: T80469

Anti-inflammatory agent 54

Cat.No: T79619

Cat.No: T65390

Cat.No: T77089

Cat.No: T78698

Citrullinated LL-37 2cit

Cat.No: T80470

Cat.No: T81423

Synonym: JTX 8064

PSMα3 acetate(1001405-52-2 Free base)

Cat.No: T38394L

Cat.No: T36401

Cat.No: T36629

Cat. No.	Product Name	Target	Signaling Pathways
T9862	Pseudocoptisine chloride 盐酸异黄连碱,Isocoptisine chloride	AChE	Neuroscience
	Pseudocoptisine chloride (Isocoptisine chloride) 是从 Corydalis Tuber 中分离出来的，具有抗炎和抗健忘的作用。 Pseudocoptisine chloride 抑制乙酰胆碱酯酶 (AChE) 活性 (IC50 = 12.8 μM)。
TN1291	7,3',4'-Tri-O-methylluteolin 5-Hydroxy-3',4',7-trimethoxyflavone,木犀草素-7,3',4'-三甲醚	TNF; COX; Interleukin	Apoptosis; Immunology/Inflammation; Neuroscience
	7,3',4'-Tri-O-methylluteolin (5-Hydroxy-3',4',7-trimethoxyflavone) 是来自草药马鞭草科的一种类黄酮，具有抗炎，解热，镇咳，抗糖尿病、抗癌和抗黑素生成特性。它以浓度依赖方式明显抑制促炎细胞因子，可显著降低在转录水平的诱导型一氧化氮合酶和环加氧酶-2 的 mRNA 表达。
T14149	AICAR phosphate AICA Riboside phosphate,Acadesine phosphate	Mitophagy; NOS; YAP; AMPK	Autophagy; Chromatin/Epigenetic; Immunology/Inflammation; PI3K/Akt/mTOR signaling; Stem Cells
	AICAR phosphate (Acadesine phosphate) 是 AMPK 激活剂且是自噬、YAP 和 mitophagy 抑制剂，也是一种腺苷类似物，可调节糖代谢和脂代谢，抑制促炎细胞因子和 iNOS 的产生。
TN6722	Terminolic acid 2α,6β,23-trihydroxyl oleanolic acid	Antibacterial	Microbiology/Virology
	Terminolic acid (2α,6β,23-trihydroxyl oleanolic acid) 是一种从 Combretum racemosum 中分离得到的五环三萜糖苷，可通过与 IL-1β 和 IL-6 的受体活性位点结合抑制促炎细胞因子，并通过与 IL-4 受体结合位点结合增强抗炎细胞因子。它还表现出适度的抗菌活性。
T5S0167	Atractylenolide I 白术内酯 I,白术内酯I；苍术内酯I	IL Receptor; TNF; TLR; JAK; STAT	Angiogenesis; Apoptosis; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; Stem Cells
	Atractylenolide I 是从白术根中得到的一种倍半萜烯，具有神经保护、抗过敏、抗炎和抗癌等多种生物活性。它是一种TLR4拮抗剂，在 A375 细胞中，能够降低JAK2和STAT3的磷酸化水平。
TN2091	Polygalacin D	Apoptosis; IAP	Apoptosis
	Polygalacin D 是从桔梗中分离的一种天然产物，具有抗癌和抗增殖特性。它通过 PI3K/Akt 途径诱导凋亡。它抑制 IAP 蛋白家族的表达，并通过抑制 GSK3β，Akt 的磷酸化和 PI3K 的表达来阻断 PI3K/Akt 途径。
T5S1895	Norisoboldine Laurelliptine,去甲异波尔定,(+)-Laurelliptine	MAPK; Adenosine Receptor	GPCR/G Protein; MAPK; Neuroscience
	Norisoboldine ((+)-Laurelliptine) 是一种可口服的芳基烃受体激动剂，是乌药中主要的异喹啉类生物碱，可用于类风湿性关节炎和溃疡性结肠炎的研究。
T5S0045	Isofraxidin 6,8-Dimethoxyumbelliferone,异秦皮啶,Phytodolor,异嗪皮啶	MMP; ERK; p38 MAPK; TLR; COX	Immunology/Inflammation; MAPK; Neuroscience; Proteases/Proteasome
	Isofraxidin (Phytodolor) 是来自刺五加的香豆素成分，抑制MMP-7表达和人肝癌细胞侵袭。它作用于肝癌细胞，抑制ERK1/2磷酸化。它减弱iNOS 和COX-2表达，还抑制TLR4/髓样分化蛋白 2 复合物的形成。
TN1831	Macranthoside A Kalopanaxsaponin H	Antioxidant	oxidation-reduction
	Macranthoside A (Kalopanaxsaponin H) 是一种从地黄中提取的三萜糖苷，属于环烯醚萜类化合。Macranthoside A 具有抗炎、抗氧化、抗菌和神经保护活性，抑制促炎细胞因子的产生和抑制炎症信号通路的激活，有助于中和有害的自由基，保护细胞免受氧化损伤，可以促进神经元的存活和生长，并防止氧化应激或神经毒性化合物引起的神经元细胞死亡，具有治疗神经退行性疾病、心血管疾病和肝损伤的潜力。
T2S2264	Linalool Linalol,(±)-Linalool,Phantol,沉香醇	Apoptosis; IL Receptor; TNF; Endogenous Metabolite; iGluR	Apoptosis; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience
	Linalool (Linalol) 是存在芫荽等植物中的单萜类天然产物，是竞争性NMDA 受体拮抗剂，具有抗肿瘤和抗心脏毒性的作用。它通过激活 Nrf2 诱导抗氧化防御和通过抑制 NF-κB 减少炎症反应来保护其免受 LPS/GalN 诱导的肝损伤，具有镇痛、抗菌和抗炎的特性。
T2563	Acetyl-L-carnitine hydrochloride Acetyl L-carnitine hydrochloride,O-Acetylcarnitine,乙酰-L-肉(毒)碱盐酸盐,O-acetyl-L-carnitine,O-Acetyl-L-carnitine hydrochloride	Others; Endogenous Metabolite	Metabolism; Others
	Acetyl-L-carnitine hydrochloride (Acetyl L-carnitine hydrochloride) 是一种由内源性左旋肉碱的乙酰化形式的盐酸盐组成的营养补充剂，具有潜在的神经保护、认知增强、抗抑郁和免疫调节活性。还可缓解化疗、糖尿病或其他疾病引起的周围神经病变。此外，乙酰左旋肉碱可能通过增加T淋巴细胞成熟来调节免疫反应，并可能下调促炎细胞因子对病毒(如SARS-CoV-2)的反应。它还可能破坏ACE2信号通路并抑制活性氧(ROS)的产生。
T3S2259	Methyl eugenol 4-allylveratrole,eugenyl methyl ether,O-methyleugenol,Eugenol Methyl ether,丁香酚甲醚,丁子香酚甲醚	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	Methyl eugenol (4-allylveratrole) 是一种苯丙类化合物，存在于植物叶子、果实、根茎中，当植物相应的部位因食草动物进食而受损时，就会释放。它可用于消灭雄性东方果蝇。
T6677	Sophocarpine	ERK; p38 MAPK; NF-κB; TLR; COX; HER; JNK; STAT	Angiogenesis; Immunology/Inflammation; JAK/STAT signaling; MAPK; Neuroscience; NF-κB; Stem Cells; Tyrosine Kinase/Adaptors
	Sophocarpine 是一种从传统草药苦参中提取的重要生物碱。苦参具有抗病毒、抗肿瘤和抗炎等多种药理作用。它通过多种机制显著抑制癌细胞的生长，具有抗肿瘤活性。
TMA2576	Episappanol	IL Receptor; TNF	Apoptosis; Immunology/Inflammation
	Episappanol has anti-inflammatory activity , it can significantly inhibit the secretion of the pro-inflammatory cytokines interleukin (IL-6) and tumor necrosis factor-alpha (TNF-α).
TN6566	Licoflavanone
	Licoflavanone exhibits antioxidant and anti-inflammatory activities,it markedly decreases pro-inflammatory cytokines and cyclooxygenase 2/inducible nitric oxide synthase (COX-2/iNOS) expression levels.
TN6366	Lupinalbin A 鲁冰花
	Lupinalbin A as the most potent estrogen receptor α- and aryl hydrocarbon receptor agonist in Eriosema laurentii de Wild. (Leguminosae). It exerts anti-inflammatory effects via the inhibition of pro-inflammatory cytokines and blocking of IFN-β/STAT1 pathw
TN4879	Questinol	IL Receptor; TNF; COX; Prostaglandin Receptor	Apoptosis; GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Questinol exhibits significant anti-obesity activity. It shows anti-inflammatory effect in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells, it can inhibit the production of pro-inflammatory cytokines, including TNF-α, IL-1β, and IL-6 and inhibit NO an
T81408	Preleoheterin
	Preleoheterin（化合物3）为一类从L. japonicus分离得到的拉丹烷二萜。
TN5912	Macluraxanthone 3-Hydroxyblancoxanthone	Antioxidant; TNF	Apoptosis; oxidation-reduction
	Macluraxanthone (3-Hydroxyblancoxanthone) 具有许多生物活性，包括抗胆碱酯酶、抗氧化、抗癌、抗疟疾、抗炎和免疫调节作用。Macluraxanthone 通过增加表达CD86的巨噬细胞的百分比，同时减少其CD14、CD11b 和CD80的表达，来促进M1类促炎症巨噬细胞的极化。Macluraxanthone 在促炎症刺激物脂多糖的存在下明显减少了TNF-α和IL-10细胞因子的产生。
T38394	PSMα3
	PSMα3 is a peptide compound that can be utilized to induce tolerance in dendritic cells (DCs) for DC vaccination strategies. It effectively penetrates and modulates human monocyte-derived DCs by modifying the maturation process induced by TLR2 or TLR4. Additionally, PSMα3 inhibits the production of both pro- and anti-inflammatory cytokines and decreases antigen uptake. Notably, PSMα3 is a significant virulence factor released by the most pathogenic strains of methicillin-resistant Staphylococcus...
T4S0083	Protostemonine	Others	Others
	Protostemonine 是一种主要从 Stemona sesslifolia 根中分离得到的生物碱，对哮喘及革兰氏阴性菌所致急性肺损伤有抗炎作用。
TN3779	De-O-methyllasiodiplodin	IL Receptor; TNF; ROS; Antifection	Apoptosis; Immunology/Inflammation; Microbiology/Virology
	De-O-methyllasiodiplodin exhibits radical scavenging, moderate antibacterial, and potential anti-inflammatory effects, it shows moderate suppression effects on induced NO production. De-O-methyllasiodiplodin effectively lowers the blood glucose level in d
TN3983	Ergosta-7,22-dien-3-one	NO Synthase; LTR	Immunology/Inflammation
	Ergosta-7,22-dien-3-one 是一种羊毛甾烷，能够从台湾灵芝的子实体中分离得到。Ergosta-7,22-dien-3-one 具有促炎特性，它能刺激一氧化氮的产生，诱导基因的表达，并诱导 J774A.1 细胞产生 TLRs、细胞因子、趋化因子和细胞粘附分子。

天然产物

Pseudocoptisine chloride

Cat.No: T9862

Synonym: 盐酸异黄连碱,Isocoptisine chloride

Target: AChE

7,3',4'-Tri-O-methylluteolin

Cat.No: TN1291

Synonym: 5-Hydroxy-3',4',7-trimethoxyflavone,木犀草素-7,3',4'-三甲醚

Target: TNF, COX, Interleukin

AICAR phosphate

Cat.No: T14149

Synonym: AICA Riboside phosphate,Acadesine phosphate

Target: Mitophagy, NOS, YAP, AMPK

Terminolic acid

Cat.No: TN6722

Synonym: 2α,6β,23-trihydroxyl oleanolic acid

Target: Antibacterial

Atractylenolide I

Cat.No: T5S0167

Synonym: 白术内酯 I,白术内酯I；苍术内酯I

Target: IL Receptor, TNF, TLR, JAK, STAT

Cat.No: TN2091

Target: Apoptosis, IAP

Cat.No: T5S1895

Synonym: Laurelliptine,去甲异波尔定,(+)-Laurelliptine

Target: MAPK, Adenosine Receptor

Cat.No: T5S0045

Synonym: 6,8-Dimethoxyumbelliferone,异秦皮啶,Phytodolor,异嗪皮啶

Target: MMP, ERK, p38 MAPK, TLR, COX

Macranthoside A

Cat.No: TN1831

Synonym: Kalopanaxsaponin H

Target: Antioxidant

Cat.No: T2S2264

Synonym: Linalol,(±)-Linalool,Phantol,沉香醇

Target: Apoptosis, IL Receptor, TNF, Endogenous Metabolite, iGluR

Acetyl-L-carnitine hydrochloride

Cat.No: T2563

Synonym: Acetyl L-carnitine hydrochloride,O-Acetylcarnitine,乙酰-L-肉(毒)碱盐酸盐,O-acetyl-L-carnitine,O-Acetyl-L-carnitine hydrochloride

Target: Others, Endogenous Metabolite

Cat.No: T3S2259

Synonym: 4-allylveratrole,eugenyl methyl ether,O-methyleugenol,Eugenol Methyl ether,丁香酚甲醚,丁子香酚甲醚

Target: GABA Receptor

Cat.No: T6677

Target: ERK, p38 MAPK, NF-κB, TLR, COX, HER, JNK, STAT

Cat.No: TMA2576

Target: IL Receptor, TNF

Cat.No: TN6566

Cat.No: TN6366

Synonym: 鲁冰花

Cat.No: TN4879

Target: IL Receptor, TNF, COX, Prostaglandin Receptor

Cat.No: T81408

Macluraxanthone

Cat.No: TN5912

Synonym: 3-Hydroxyblancoxanthone

Target: Antioxidant, TNF

Cat.No: T38394

Protostemonine

Cat.No: T4S0083

Target: Others

De-O-methyllasiodiplodin

Cat.No: TN3779

Target: IL Receptor, TNF, ROS, Antifection

Ergosta-7,22-dien-3-one

Cat.No: TN3983

Target: NO Synthase, LTR

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼