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Search Results for " lipid peroxidation "

72

抑制剂 & 化合物

43

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T10166	Lipid peroxidation inhibitor 1	Others	Others
	Lipid peroxidation inhibitor 1 is an inhibitor of lipid peroxidation (IC50: 0.07 μM).
T0342	Carvedilol phosphate hemihydrate Carvedilol phosphate,BM 14190 (phosphate hemihydrate),卡维地洛磷酸盐	VEGFR; Others; Potassium Channel; LDL; Integrin; Gap Junction Protein; NADPH; Adrenergic Receptor; Autophagy	Angiogenesis; Autophagy; Cytoskeletal Signaling; GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Neuroscience; Others; Tyrosine Kinase/Adaptors
	Carvedilol phosphate hemihydrate (BM 14190 phosphate hemihydrate) 是一种外消旋混合物，是一种非选择性β/α-1受体阻断剂，具有抗高血压活性且缺乏内在拟交感神经活性。
T60084	FINO2	Ferroptosis	Apoptosis
	FINO2 is a potent ferroptosis-inducing compound that inhibits GPX4 activity. It functions as a stable oxidant, effectively oxidizing ferrous iron and demonstrating stability across varying pH levels. Furthermore, FINO2 induces widespread lipid peroxidation.
T9956	VK-28	Mitochondrial Metabolism; Lipid	Metabolism
	VK-28 是一种具有神经保护作用的脑渗透性铁螯合剂。 VK-28 抑制基础以及铁诱导的线粒体脂质过氧化。
T77288	KKII5	Lipoxygenase	Metabolism
	KKII5 是一种有效的脂氧合酶 LOX-1 抑制剂，IC50 为 19 μM。KKII5 抑制脂质过氧化，增强部分化合物活性中心接收电子的能力。
T5523	Imidazole ketone erastin IKE	Ferroptosis	Apoptosis
	Imidazole ketone erastin (IKE) 是一种铁死亡诱导剂，对 system Xc-胱氨酸/谷氨酸转运蛋白具有抑制作用。Imidazole ketone erastin 具有抗肿瘤活性，可以诱导谷胱甘肽耗竭和脂质过氧化。
T28978	Tirilazad mesylate U-74006 mesylate,U74006 mesylate,U 74006 mesylate,U 74006F mesylate,U-74006F mesylate,U74006F mesylate	Antiviral	Immunology/Inflammation
	Tirilazad mesylate (U 74006F) 是一种非糖皮质激素，是一种脂质过氧化抑制剂，具有抗病毒活性和神经保护活性。Tirilazad mesylate 能使细胞膜内病灶局限化，可减轻创伤、中风、缺血再灌注损伤引起的脊髓损伤，抑制狗体内毒素的作用，降低了内毒素诱导的肠系膜和肾脏 DO2 比容升高。Tirilazad mesylate 可用于研究神经系统疾病。
T4313	Tinoridine hydrochloride 盐酸替诺立定,Nonflamin,Y-3642 hydrochloride	COX; Glutathione Peroxidase	Immunology/Inflammation; Metabolism; Neuroscience
	Tinoridine hydrochloride (Y-3642 hydrochloride) 是非甾体抗炎药，具有显著的自由基清除和抗过氧化物特性。
T63081	KS106
	KS106 是一种 ALDH 的有效抑制剂，能够作用于 ALDH1A1 (IC50: 334 nM)、ALDH2 (IC50: 2137 nM) 和 ALDH3A1 (IC50: 360 nM)。KS106 具有抗增殖和抗癌作用，且毒性较低。KS106 可将细胞周期阻滞在G2/M 期，饼诱导细胞凋亡。KS106 能够明显提高 ROS 活性、脂质过氧化和有毒醛的积累。
T63992	KS100
	KS100 是 ALDH 的有效抑制剂，能够作用于 ALDH1A1 (IC50: 334 nM)、ALDH2 (IC50: 2137 nM) 和 ALDH3A1 (IC50: 360 nM)。KS100 能够明显提高 ROS 活性、脂质过氧化和有毒醛的积累，且具有低毒性的抗增殖和抗癌活性。KS100 能够将细胞周期阻滞在 G2/M 期，并诱导细胞凋亡 (apoptosis)。
T25829	Mopidamol RA233,RA 233,RA-233,Rapenton,OLX 102	PDE	Metabolism
	Mopidamol (RA 233) 是一种磷酸二酯酶抑制剂，是 dipyridamole 衍生物，具有抗癌活性，可预防实验性糖尿病的视网膜血管缺陷。
T35689	MTP 131 acetate	Others	Others
	MTP 131 acetate 是一种小的线粒体靶向四肽。
T23853	Carazostatin
	Carazostatin is an antioxidant, free radical scavenger, and potent lipid peroxidation inhibitor.
T28673	SB 209995 SB-209995,SB209995
	SB 209995, a potent antioxidant, inhibits oxygen-radical-mediated lipid peroxidation and cytotoxicity.
T30863	CH 402 CH-402,CH402
	CH 402 inhibits lipid peroxidation.
T69427	Peridinin
	Peridinin is an exceptionally potent and membrane-embedded inhibitor of bilayer lipid peroxidation.
T24255	KB 5666 KB-5666,KB5666
	KB 5666, a quinazoline derivative, is a lipid peroxidation inhibitor. It protects the brain from both cellular and functional consequences of ischemia.
T69462	Deulinoleic acid
	Deulinoleic acid is a lipid peroxidation inhibitor and antioxidant.
T36002	4-hydroxy Hexenal 4-HHE,4-hydroxy Hexenal
	4-hydroxy Hexenal is a lipid peroxidation product derived from oxidized ω-3 fatty acids such as DHA. [1][2]
T70947	U-78517F
	U-78517F is a potent inhibitor of lipid peroxidation.
T19465	N6-Etheno 2'-deoxyadenosine	Others	Others
	N6-Etheno 2'-deoxyadenosine is used as a biomarker to evaluate chronic inflammation and lipid peroxidation in animal or human tissues.
T28082	Mollugogenol A
	Mollugogenol A is a Gammacerane from Mollugo pentaphylla. It is an antifungal saponin with spermatocidal activity. Mollugogenol A also involves sperm membrane damage by increased lipid peroxidation.
T70708	U 92032
	U 92032 is a T-channel antagonist and antioxidant that inhibits lipid peroxidation.
T35963	MitoPerOx
	MitoPerOx is a ratiometric fluorescent probe that can be used to assess changes in lipid peroxidation within mitochondria. It is composed of a BODIPY fluorophore conjugated via a dienyl link to a triphenylphosphonium cation component that drives its accumulation in mitochondria. MitoPerOx displays an excitation maximum of 495 nm and exhibits a shift in emission maxima from 590 to 520 nm upon mitochondrial lipid peroxidation, enabling determination of ratiometric measurements of lipid peroxidatio...
T69867	BN80933
	BN80933 is a dual inhibitor of lipid peroxidation and neuronal nitric oxide synthase; Neuroprotectant.
T35646	4-oxo-2-Nonenal 4-oxo-2-Nonenal,4-ONE
	4-hydroxy Nonenal is a lipid peroxidation product derived from oxidized ω-6 polyunsaturated fatty acids such as arachidonic acid and linoleic acid. [1] [2] It exhibits various biological activities such as cytotoxicity, growth inhibiting activity, genotoxicity, and chemotactic activity and has been widely used as a marker of lipid peroxidation.[1][2][3] 4-oxo-2-Nonenal is a more recently identified product of lipid peroxidation.[4][5][6] It actively modifies histidine and lysine residues on prot...
T36509	U-74389G U-74389G,Methylated Tirilazad
	U-74389G is an antioxidant which prevents iron-dependent lipid peroxidation. It protects against ischemia-reperfusion injury in animal heart, liver, and kidney models.[1],[2],[3],[4]
T22370	Mitoquinol mesylate	Others	Others
	Mitoquinol, a ubiquinone derivative, specifically accumulates in mitochondria due to the covalent attachment of the cation triphenylphosphonium. Mitoquinol is an antioxidant, protecting mitochondria from oxidative damage and preventing lipid peroxidation-
T36175	AAPH
	AAPH is a water-soluble azo compound which is used extensively as a free radical generator, often in the study of lipid peroxidation and the characterization of antioxidants.[1],[2],[3],[4] Decomposition of AAPH produces molecular nitrogen and 2 carbon radicals. The carbon radicals may combine to produce stable products or react with molecular oxygen to give peroxyl radicals. The half-life of AAPH is about 175 hours (37°C at neutral pH), making the rate of free radical generation essentially con...
T39652	BODIPY 581/591 C11 BODIPY 581/591 C11
	C11-BODIPY581/591 is a fluorescent ratio-probe of lipid oxidation . C11-BODIPY581/591 is often used for indexing lipid peroxidation and antioxidant efficacy in model membrane systems and living cells. C11-BODIPY581/591 is applied in the quantitation of ferroptosis.
T35846	13(R)-HODE cholesteryl ester
	13(R)-HODE cholesteryl ester was originally extracted from atherosclerotic lesions. It remains uncertain whether the oxidized fatty acid portion of the molecule results from enzymatic lipoxygenation or from random lipid peroxidation. 13(R)-HODE cholesteryl ester can be used as a standard for analysis of chiral HODE cholesteryl esters.
T36168	8-iso-16-cyclohexyl-tetranor Prostaglandin E2 8-iso-16-cyclohexyl-tetranor Prostaglandin E2
	8-iso Prostaglandin E2 (8-iso PGE2) is one of several isoprostanes produced from polyunsaturated fatty acids during lipid peroxidation. 8-iso-16-cyclohexyl-tetranor PGE2 is a synthetic analog of 8-iso PGE2. There are no published studies on the pharmacological properties of 8-iso-16-cyclohexyl-tetranor PGE2.
T35853	9(S)-HODE cholesteryl ester
	9(S)-HODE cholesteryl ester was originally extracted from atherosclerotic lesions. It remains uncertain whether the oxidized fatty acid portion of the molecule results from enzymatic lipoxygenation or from random lipid peroxidation. 9(S)-HODE cholesteryl ester can be used as a standard for analysis of chiral HODE cholesteryl esters.
T35843	9(R)-HODE cholesteryl ester
	9(R)-HODE cholesteryl ester was originally extracted from atherosclerotic lesions. It remains uncertain whether the oxidized fatty acid portion of the molecule results from enzymatic lipoxygenation or from random lipid peroxidation. 9(R)-HODE cholesteryl ester can be used as a standard for analysis of chiral HODE cholesteryl esters.
T68948	Detorubicin HCl
	Detorubicin is a semi-synthetic derivative of the anthracycline antineoplastic antibiotic daunorubicin. Detorubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. This agent also produces toxic free-radical intermediates and interacts with cell membrane lipids causing lipid peroxidation. Detorubicin is less toxic than daunorubicin.
T36169	15-LOX-1 inhibitor 1
	9c(i472) is an inhibitor of 15-lipoxygenase-1 (15-LO-1; IC50 = 0.19 μM).1 It decreases LPS- and IFN-γ-induced NF- B activity in RAW-Blue cells when used at concentrations of 0.2, 1, and 5 μM. 9c(i472) reduces LPS- and IFN-γ-induced increases in Nos2 expression and lipid peroxidation in RAW 264.7 cells when used at a concentration of 5 μM.
T67870	DKI5 (E)-N'-benzylidenehydrazinecarbothiohydrazide	Lipoxygenase	Metabolism
	DKI5 ((E)-N'-benzylidenehydrazinecarbothiohydrazide) 是一种 LOX-1 抑制剂，IC50 值为 22.5 μM。DKI5 可能具有抗炎和抗氧化活性，在体外生物测定中显示出抗脂质过氧化活性。
T35462	(±)11-HETE
	(±)11-HETE is one of the six monohydroxy fatty acids produced by the non-enzymatic oxidation of arachidonic acid . The individual R and S isomers of racemic HETEs have been separated and identified using chiral phase HPLC. The racemic HETEs have been quantified as an index of lipid peroxidation using GC/MS.
T68909	Detorubicin Free Base
	Detorubicin Free Base is a semi-synthetic derivative of the anthracycline antineoplastic antibiotic daunorubicin. Detorubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. This agent also produces toxic free-radical intermediates and interacts with cell membrane lipids causing lipid peroxidation. Detorubicin is less toxic than daunorubicin.
T36558	(±)9-HETE
	(±)9-HETE is one of the six monohydroxy fatty acids produced by the non-enzymatic oxidation of arachidonic acid. The individual R and S isomers of racemic HETEs have been separated and identified using chiral phase HPLC. The racemic HETEs have been quantified as an index of lipid peroxidation using GC/MS.
T25943	Phenazoviridin
	Phenazoviridin 是一种新发现的微生物自由基清除剂，从链霉菌 HR04的培养基中分离得到。它是一种抗低氧化合物，对大鼠脑匀浆中的脂质过氧化具有较强的抑制活性，对小鼠具有抗缺氧活性。
T78548	3-Hydroxyxanthone 3-Hydroxy-xanthen-9-one	Integrin	Cytoskeletal Signaling
	3-Hydroxyxanthone (3-Hydroxy-xanthen-9-one) 是一种具有抗炎活性的氧杂蒽酮化合物。它能抑制人脐静脉内皮细胞（HUVEC）中NADPH催化的脂质过氧化，并且阻止TNF-α所诱导的ICAM-1表达。
T36160	8-iso Prostaglandin E2 8-iso Prostaglandin E2
	8-iso PGE2 is one of several isoprostanes produced from arachidonic acid during lipid peroxidation. It is a potent renal vasoconstrictor in the rat. 8-iso PGE2 inhibits U-46619 or I-BOP-induced platelet aggregation with IC50 values of 0.5 and 5 μM, respectively. When infused into the renal artery of the rat at a concentration of 4 μg/kg/min, 8-iso PGE2 decreases the GFR and renal plasma flow by 80% without affecting blood pressure.
T36003	1(R)-(Trifluoromethyl)oleyl alcohol
	1(R)-(Trifluoromethyl)oleyl alcohol is an analog of oleic acid .1It inhibits ferroptosis induced by erastin in primary fibroblasts isolated from patients with Friedreich ataxia, a neuro- and cardiodegenerative disorder characterized by loss or impaired activity of frataxin (FXN), when used at concentrations of 5, 10, or 20 μM. 1(R)-(Trifluoromethyl)oleyl alcohol (5 μM) reduces lipid peroxidation induced byFXNsiRNA knockdown in NBT human myoblasts. 1.Cotticelli, M.G., Forestieri, R., Xia, S., et ...
T71326	1,3,7-Trimethyluric Acid-d9
	1,3,7-Trimethyluric acid-d9 is intended for use as an internal standard for the quantification of 1,3,7-trimethyluric acid by GC- or LC-MS. 1,3,7-Trimethyluric acid is a derivative of uric acid and a metabolite of caffeine. It is formed from caffeine by the cytochrome P450 isoform CYP3A4. 1,3,7-Trimethyluric acid scavenges hydroxyl radicals in a cell-free assay and inhibits t-butyl hydroperoxide-induced lipid peroxidation by 56.5% in isolated human erythrocyte membranes.
T35993	Epitalon (acetate)
	Epitalon is a synthetic tetrapeptide with anti-aging properties.1,2,3,4 Dietary administration of epitalon (0.00001% w/w) reduces levels of lipid peroxidation products in aged D. melanogaster tissue homogenates.1 Epitalon (1 μg/animal) delays age-related estrous shutdown and decreases the frequency of bone marrow cell chromosomal aberrations in female mice.2 It decreases spontaneous mammary gland and ovarian tumor development and metastasis in aged female mice.3 Epitalon also stimulates melatoni...
T82408	Ferroptosis-IN-3	Ferroptosis	Apoptosis
	Ferroptosis-IN-3（Compound 25）是一款抑制RSL3引起的铁死亡（HT-1080细胞中EC50为8.6nM）的铁死亡抑制剂。此外，Ferroptosis-IN-3能有效清除DPPH和ABTS自由基（EC50分别为3.94μM与6.3μM），并且能降低脂质过氧化水平。
T81120	SP4f	PPAR	DNA Damage/DNA Repair; Metabolism
	SP4f为PPAR-γ激活剂，其在HK-2细胞中EC50值为826 nM。在瑞士白化病小鼠中，SP4f能够降低血糖和脂质过氧化水平，同时提升谷胱甘肽含量和过氧化氢酶活性。
T81121	SP4e	PPAR	DNA Damage/DNA Repair; Metabolism
	SP4e是一种PPAR-γ激活剂，其在HK-2细胞中展现出的EC50为739 nM。在瑞士白化病小鼠模型中，SP4e能有效降低血糖和脂质过氧化水平，并提升谷胱甘肽含量及过氧化氢酶的活性。
T36001	4-hydroperoxy 2-Nonenal
	4-hydroxy Nonenal is a lipid peroxidation product derived from oxidized ω-6 polyunsaturated fatty acids, such as linoleic acid and arachidonic acid, that is widely used as a marker of oxidative stress. 4-HNE exhibits various biological activities such as cytotoxicity, growth inhibiting activity, genotoxicity, and chemotactic activity. 4-hydroperoxy 2-Nonenal is the immediate precursor of 4-HNE formed from the cleavage of ω-6 hydroperoxides. Analogous reactions are expected to occur with hydroper...

化合物

Lipid peroxidation inhibitor 1

Cat.No: T10166

Target: Others

Carvedilol phosphate hemihydrate

Cat.No: T0342

Synonym: Carvedilol phosphate,BM 14190 (phosphate hemihydrate),卡维地洛磷酸盐

Target: VEGFR, Others, Potassium Channel, LDL, Integrin, Gap Junction Protein, NADPH, Adrenergic Receptor, Autophagy

Cat.No: T60084

Target: Ferroptosis

Cat.No: T9956

Target: Mitochondrial Metabolism, Lipid

Cat.No: T77288

Target: Lipoxygenase

Imidazole ketone erastin

Cat.No: T5523

Synonym: IKE

Target: Ferroptosis

Tirilazad mesylate

Cat.No: T28978

Synonym: U-74006 mesylate,U74006 mesylate,U 74006 mesylate,U 74006F mesylate,U-74006F mesylate,U74006F mesylate

Target: Antiviral

Tinoridine hydrochloride

Cat.No: T4313

Synonym: 盐酸替诺立定,Nonflamin,Y-3642 hydrochloride

Target: COX, Glutathione Peroxidase

Cat.No: T63081

Cat.No: T63992

Cat.No: T25829

Synonym: RA233,RA 233,RA-233,Rapenton,OLX 102

Target: PDE

MTP 131 acetate

Cat.No: T35689

Target: Others

Cat.No: T23853

Cat.No: T28673

Synonym: SB-209995,SB209995

Cat.No: T30863

Synonym: CH-402,CH402

Cat.No: T69427

Cat.No: T24255

Synonym: KB-5666,KB5666

Deulinoleic acid

Cat.No: T69462

4-hydroxy Hexenal

Cat.No: T36002

Synonym: 4-HHE,4-hydroxy Hexenal

Cat.No: T70947

N6-Etheno 2'-deoxyadenosine

Cat.No: T19465

Target: Others

Cat.No: T28082

Cat.No: T70708

Cat.No: T35963

Cat.No: T69867

4-oxo-2-Nonenal

Cat.No: T35646

Synonym: 4-oxo-2-Nonenal,4-ONE

Cat.No: T36509

Synonym: U-74389G,Methylated Tirilazad

Mitoquinol mesylate

Cat.No: T22370

Target: Others

Cat.No: T36175

BODIPY 581/591 C11

Cat.No: T39652

Synonym: BODIPY 581/591 C11

13(R)-HODE cholesteryl ester

Cat.No: T35846

8-iso-16-cyclohexyl-tetranor Prostaglandin E2

Cat.No: T36168

Synonym: 8-iso-16-cyclohexyl-tetranor Prostaglandin E2

9(S)-HODE cholesteryl ester

Cat.No: T35853

9(R)-HODE cholesteryl ester

Cat.No: T35843

Detorubicin HCl

Cat.No: T68948

15-LOX-1 inhibitor 1

Cat.No: T36169

Cat.No: T67870

Synonym: (E)-N'-benzylidenehydrazinecarbothiohydrazide

Target: Lipoxygenase

Cat.No: T35462

Detorubicin Free Base

Cat.No: T68909

Cat.No: T36558

Cat.No: T25943

3-Hydroxyxanthone

Cat.No: T78548

Synonym: 3-Hydroxy-xanthen-9-one

Target: Integrin

8-iso Prostaglandin E2

Cat.No: T36160

Synonym: 8-iso Prostaglandin E2

1(R)-(Trifluoromethyl)oleyl alcohol

Cat.No: T36003

1,3,7-Trimethyluric Acid-d9

Cat.No: T71326

Epitalon (acetate)

Cat.No: T35993

Ferroptosis-IN-3

Cat.No: T82408

Target: Ferroptosis

Cat.No: T81120

Target: PPAR

Cat.No: T81121

Target: PPAR

4-hydroperoxy 2-Nonenal

Cat.No: T36001

Cat. No.	Product Name	Target	Signaling Pathways
T19161	7α-Hydroxycholesterol	Others	Others
	7α-Hydroxycholesterol 是一种由酶促氧化和非酶促氧化形成的胆固醇氧化物，可用作脂质过氧化的生物标志物。
T7982	3,6-Dihydroxyflavone	Others	Others
	3,6-Dihydroxyflavone 是一种抗癌剂。它能够提高细胞内氧化应激和脂质过氧化。它是能够根据剂量和时间依赖性地降低细胞活力，并活化半胱天冬酶级联、切割聚 (ADP-核糖) 聚合酶 (PARP) 诱导细胞凋亡。
T0626	Uric Acid 尿酸,2,6,8-Trioxopurine,2,6,8-Trioxypurine,2,6,8-Trihydroxypurine,Lithic acid,Urate	Reactive Oxygen Species; Endogenous Metabolite; Phosphorylase	Immunology/Inflammation; Metabolism; NF-κB
	Uric Acid (Lithic acid) 是一种重要的抗氧化剂。Uric acid 能清除活性氧(ROS) ，如单线态氧和过氧亚硝酸盐，抑制脂质过氧化。Uric acid 有助于维持血压的稳定和抗氧化应激。
TN2158	Robinetin 3,3',4',5',7-Pentahydroxyflavone,洋槐黄素	Anti-infection; HIV Protease; Antibacterial	Microbiology/Virology; Proteases/Proteasome
	Robinetin (3,3',4',5',7-Pentahydroxyflavone) 是一种天然黄酮，具有显著的“两种颜色”固有荧光特性。它具有抗真菌、抗病毒、抗菌、抗突变、抗氧化和抗自由基活性，高效抑制 EYPC 膜脂质过氧化和 HbA 糖基化。
T37710	5-Hydroxyoxindole	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	5-Hydroxyoxindole 是尿酸的一种结构类似物，具有脂质过氧化抑制活性和自由基 DPPH 清除活性，可用于氧化应激介导的疾病的研究。
TN4973	Sculponeatin O	Others	Others
	Sculponeatin O 是一种 ent-kaurane 二萜衍生物，分离自 Isodon sculponeata 植物。
TN4972	Sculponeatin N	Others	Others
	Sculponeatin N 是一种 ent-kaurane 二萜衍生物，分离自 Isodon sculponeata 植物。
TN1644	Flavanomarein	Others	Others
	Flavanomarein 是Coreopsis tinctoria Nutt 的主要黄酮类化合物，对糖尿病性肾病具有保护作用。它具有很好的抗氧化，降糖，降压和降血脂作用。
TN3120	5-Hydroxy-7-acetoxy-8-methoxyflavone	Histone Demethylase; Antiviral	Chromatin/Epigenetic; Immunology/Inflammation
	5-Hydroxy-7-acetoxy-8-methoxyflavone 是一种类黄酮化合物，可以抑制脂质过氧化，可能具有抗流感病毒活性。
TN1863	Licoisoflavone A Phaseoluteone	MRP	Immunology/Inflammation
	Licoisoflavone A (Phaseoluteone) 是一种 MRP 抑制剂，可抑制脂质过氧化，IC50 为 7.2 μM。
T4241	Rubiadin 1,3-Dihydroxy-2-Methylanthracene-9,10-Dione,茜根定,茜草素	Free radical scavengers; PARP; Caspase	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; oxidation-reduction; Proteases/Proteasome
	Rubiadin (1,3-Dihydroxy-2-Methylanthracene-9,10-Dione) 是一种二羟基蒽醌，提取自茜草，具有抗氧化剂作用。
T19792	1,3,7-Trimethyluric acid	Others	Others
	1,3,7-Trimethyluric acid 是咖啡因的代谢产物。其与咖啡因的代谢比可以反映 CYP3A 活性的变化情况。
TN1962	Myricetin 3-O-galactoside Myricetin 3-O-beta-D-galactopyranoside	NOS; Xanthine Oxidase	Immunology/Inflammation; Metabolism
	Myricetin 3-O-galactoside (Myricetin 3-O-beta-D-galactopyranoside) 可抑制黄嘌呤氧化酶 (xanthine oxidase; XO) 活性，脂质过氧化并清除自由基。杨梅素3- o -半乳糖苷具有很多作用包括细胞毒性、抗氧化、抗基因毒性、抗感染性、抗炎作用和抗氧化活性，其主要作用是抑制诱导型一氧化氮合酶(iNOS)的合成。Myricetin 3-O-galactoside 抑制脂质过氧化的 IC50 为 160 μg/mL。
T0131	Cepharanthine NSC-623442,千金藤碱,千金藤素	Apoptosis; TNF; HIV Protease; Autophagy	Apoptosis; Autophagy; Microbiology/Virology; Proteases/Proteasome
	Cepharanthine (NSC-623442) 是从Stephania cepharanthaHayata 中提取的一种生物碱，具有抗炎、抗氧化作用。它可抑制肿瘤坏死因子 (TNF)-α 介导的 NFκB 刺激、质膜脂质过氧化和血小板聚集，并抑制细胞因子的产生。
T5S0636	Citric acid 柠檬酸,Citro,Citretten	Apoptosis; Others; Endogenous Metabolite; Antibacterial; Antibiotic	Apoptosis; Metabolism; Microbiology/Virology; Others
	Citric acid (Citro) 是柑橘类水果中发现的弱有机三羧酸。柠檬酸是食品添加剂和天然防腐剂。
T5S1285	(+)-(3R,8S)-Falcarindiol Falcarindiol,镰叶芹二醇	Others	Others
	(+)-(3R,8S)-Falcarindiol 是一种从胡萝卜中得到的聚乙炔，有抗炎、抗肿瘤和抗脂质过氧化活性。它具有抗分歧杆菌作用，对Mycobacterium tuberculosisH37Ra 的 MIC 和 IC50值分别为 24 μM 和 6 μM。
T2O2741	Thiamine monochloride Thiamine chloride,Vitamin B1	Others; Antioxidant; Endogenous Metabolite; Antibacterial	Metabolism; Microbiology/Virology; Others; oxidation-reduction
	Thiamine monochloride (Vitamin B1) 是人体必不可少的维生素，具有促红细胞生成、调节血糖、抗氧化和调节情绪的作用。Thiamine monochloride 抑制铅引起的脂质过氧化反应，从而防止铅中毒。Thiamine monochloride 在摄入食物的细胞产生能量中起重要作用，并能增强正常的神经元活性。
TN1624	Ethyl cinnamate	Calcium Channel; ROS; NO Synthase	Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism
	Ethyl cinnamate 是食品香料和化妆品添加剂，也是哺乳动物组织的优良清除剂。
TN1725	Hederacolchiside E 革叶常春藤皂苷E	Beta Amyloid; ROS	Immunology/Inflammation; Neuroscience
	Hederacolchiside E 具有抗氧化活性，并通过调节氧化应激在阿尔茨海默病 (AD) 模型中显示神经保护作用。 Hederacolchiside E 对亚油酸乳液的脂质过氧化具有抑制作用。 Hederacolchiside E 可能通过阻断缓激肽或其他炎症介质发挥其抗炎作用。
TJS0315	4-Methyldaphnetin 7,8-Dihydroxy-4-methylcoumarin,4-甲基瑞香素,DHMC,7,8-二羟基-4-甲基香豆素	Apoptosis; Lipoxygenase	Apoptosis; Metabolism
	4-Methyldaphnetin (DHMC) 是一种合成 4-甲基香豆素衍生物的前体。它对几种肿瘤细胞株具有选择性的抗增殖和诱导凋亡的作用。它能够清除自由基，显著抑制膜脂过氧化。
T4868	gamma-Linolenic acid gamolenic acid,γ-Linolenic acid,γ-亚麻酸	Endogenous Metabolite	Metabolism
	gamma-Linolenic acid (gamolenic acid) 是一种 omega-6 (n-6)，18 碳 (18C-) 多不饱和脂肪酸 (PUFA)，可以从人乳和植物种子油中提取。
T41242	Uric acid sodium	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	Uric acid sodium 是氧自由基 (oxygen radical) 的清除剂，是一种有效的、常见的抗氧化剂，有助于维持机体血压稳定和抗氧化应激。Uric acid sodium 能清除活性氧 (ROS)，如单线态氧和过氧亚硝酸盐，对脂质过氧化有抑制作用，与痛风性关节病的发病机理和草酸钙结石的形成有关。
T5S1097	Neferine (R)-1,2-Dimethoxyaporphine,(-)-Neferine,甲基莲心碱	Apoptosis; NF-κB; Autophagy	Apoptosis; Autophagy; NF-κB
	Neferine ((-)-Neferine) 是一种双苄基异喹啉类生物碱，可强效抑制NF-κB 激活，具有抗肿瘤活性。
T2924	Phloretin 根皮素,Dihydronaringenin,NSC 407292,RJC 02792	SGLT; transporter; Endogenous Metabolite	GPCR/G Protein; Metabolism
	Phloretin (NSC-407292) 是从苹果树叶中提取的一种查耳酮，具有抗炎、抗氧化和抗癌活性。它是真核尿素转运蛋白抑制剂，可阻断 VacA 介导的尿素和离子转运，有潜力用于类风湿性关节炎和过敏性气道炎症的相关研究。
T5S0106	Peimisine 贝母辛,Ebeiensine	RAAS; AChR	Endocrinology/Hormones; Neuroscience
	Peimisine (Ebeiensine) 非竞争性拮抗气管平滑肌 M 受体，抑制 Ach 引起的平滑肌收缩。它兴奋 β 受体和拮抗内钙释放，促进一氧化氮释放，可舒张气管平滑肌，有平喘作用。
T31102	Cryptopine NSC32984,Kryptocavin,Cryptocavine,Kryptopine,Cryptopin
	Cryptopine in vivo disturbs the cellular defense system, so that it tips in the direction of autoxidative lipid peroxidation, producing cytotoxicity.
T13521	6"-O-Acetyldaidzin	Others	Others
	6-O-Acetyldaidzin is an isoflavone glycoside isolated from soybeans. It significantly inhibits lipid peroxidation in rat liver microsome (IC50: 8.2 μM).
TN4406	Lamiide
	Lamiide has anti-inflammatory activity in carrageenin-induced paw edema test. It shows lipid peroxidation inhibition on rat-brain phospholipid peroxidation.
T74202	Hispaglabridin A
	Hispaglabridin A 是一种抗氧化剂，可有效防止脂质过氧化。
TN3069	4beta-Carboxy-19-nortotarol	NADPH-oxidase	Immunology/Inflammation
	4 beta-Carboxy-19-nortotarol can inhibit microsomal lipid peroxidation induced by Fe(III)-ADP/NADPH and mitochondrial lipid peroxidation induced by Fe(III)-ADP/ NADH, it inhibits linoleic acid autoxidation but not generation of superoxide anion.
TN1896	Luteolin 5-O-glucoside 藤黄菌素,Luteollin 5-glucoside,木犀草素-5-O-葡萄糖苷	Others	Others
	Luteolin 5-O-α2-glucopyranoside has antioxidant activity, it can inhibit lipid peroxidation, and has DPPH radical-scavenging activity.
T3S2210	Lancerin	Others	Others
	Lancerin 是提取自 Cudraniu cochinchinensis 的根皮中，有抗脂质过氧化活性。
TN4770	Phyllostadimer A	Others	Others
	Phyllostadimer A can significantly inhibit liposomal lipid peroxidation.
T14062	6"-O-Acetylgenistin	Others	Others
	6-O-Acetylgenistin is an isoflavone glycoside isolated from soybeans. 6-O-Acetylgenistin significantly inhibits lipid peroxidation in rat liver microsome with an IC50 of 10.6 μM[1][2].
TN1588	Dihydroisotanshinone I 二氢异丹参酮I,二氢丹参酮	ATPase; Potassium Channel; Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Dihydroisotanshinone I has protective action against menadione-induced hepatotoxicity, attributed to its antioxidant properties including the free radical scavenging activity and inhibition of lipid peroxidation.
T40368	4-Ethylresorcinol
	4-Ethylresorcinol, a derivative of resorcinol, functions as a tyrosinase substrate, possesses hypopigmentary effects, attenuates mRNA and protein expression of tyrosinase-related protein-2 (TRP-2), and exhibits antioxidative properties through inhibition of lipid peroxidation.
TN4388	Kielcorin	Antifection	Microbiology/Virology
	Kielcorin shows antibacterial activity against strain EMRSA-16. It also shows in vitro anti-inflammatory (respiratory burst) inhibiting activities using isolated human neutrophils (IC (50) = 965.21 ± 65.80 uM). trans-Kielcorin has hepatoprotective activity, it can prevent tert-butylhydroperoxide-induced lipid peroxidation and cell death in freshly isolated rat hepatocytes.
T81325	Quercetin 3-O-rutinoside-7-O-glucoside
	Quercetin 3-O-rutinoside-7-O-glucoside（化合物 8）为一抗氧化剂，源自Hemerocallis fulva，展现出显著抑制脂质过氧化的活性。
TN4877	Quercetin 3,4'-dimethyl ether	ERK; BCL; MAPK; Caspase; JNK	Apoptosis; MAPK; Proteases/Proteasome
	Quercetin 3,4'-dimethyl ether shows anti-lipid peroxidation activity (IC 50 values of 0.3 uM), it also shows anti-inflammatory activity. Quercetin 3,4'-dimethyl ether could be useful in the development of novel anticancer agents, it has high cytotoxic aga
TN4212	Hirsutanonol	COX; Antifection	Immunology/Inflammation; Microbiology/Virology; Neuroscience
	Hirsutanonol 是来自桤木树皮的次生代谢物。 Hirsutanonol 具有有效的抗氧化和自由基清除活性，并对线粒体脂质过氧化具有抑制作用。 Hirsutanonol 可用于治疗特应性皮炎的研究。
TN2876	3,4-Dihydroxy-2-methoxyxanthone	Antibacterial; Antifection	Microbiology/Virology
	3,4-Dihydroxy-2-methoxyxanthone 显示出抗菌和保肝活性，它能防止叔丁基过氧化氢诱导的新鲜离体大鼠肝细胞的脂质过氧化和细胞死亡，并在一定程度上有效防止细胞谷胱甘肽平衡的扰乱。
T82278	Glyurallin B
	Glyurallin B, 一种黄酮类化合物，可从Glycyrrhiza infata和Glycyrrhiza uralensis中提取。该化合物展现出ABTS+自由基清除活性与脂质过氧化抑制活性，其EC50值分别为11.9 ± 0.58 μM和15.3 ± 1.26 μM。
T72594	Broussochalcone A
	Broussochalcone A 是一种具有抗氧化和抑制黄嘌呤氧化酶（IC50=2.21 μM）功能的化合物，能清除自由基，抑制铁诱导的脂质过氧化和脂多糖（LPS）激活的巨噬细胞中一氧化氮（NO）的合成。此外，Broussochalcone A 通过增加ROS水平和激活FOXO3信号通路，诱导人肾癌细胞的凋亡（Apoptosis）。

天然产物

7α-Hydroxycholesterol

Cat.No: T19161

Target: Others

3,6-Dihydroxyflavone

Cat.No: T7982

Target: Others

Cat.No: T0626

Synonym: 尿酸,2,6,8-Trioxopurine,2,6,8-Trioxypurine,2,6,8-Trihydroxypurine,Lithic acid,Urate

Target: Reactive Oxygen Species, Endogenous Metabolite, Phosphorylase

Cat.No: TN2158

Synonym: 3,3',4',5',7-Pentahydroxyflavone,洋槐黄素

Target: Anti-infection, HIV Protease, Antibacterial

5-Hydroxyoxindole

Cat.No: T37710

Target: Reactive Oxygen Species

Cat.No: TN4973

Target: Others

Cat.No: TN4972

Target: Others

Cat.No: TN1644

Target: Others

5-Hydroxy-7-acetoxy-8-methoxyflavone

Cat.No: TN3120

Target: Histone Demethylase, Antiviral

Licoisoflavone A

Cat.No: TN1863

Synonym: Phaseoluteone

Target: MRP

Cat.No: T4241

Synonym: 1,3-Dihydroxy-2-Methylanthracene-9,10-Dione,茜根定,茜草素

Target: Free radical scavengers, PARP, Caspase

1,3,7-Trimethyluric acid

Cat.No: T19792

Target: Others

Myricetin 3-O-galactoside

Cat.No: TN1962

Synonym: Myricetin 3-O-beta-D-galactopyranoside

Target: NOS, Xanthine Oxidase

Cat.No: T0131

Synonym: NSC-623442,千金藤碱,千金藤素

Target: Apoptosis, TNF, HIV Protease, Autophagy

Cat.No: T5S0636

Synonym: 柠檬酸,Citro,Citretten

Target: Apoptosis, Others, Endogenous Metabolite, Antibacterial, Antibiotic

(+)-(3R,8S)-Falcarindiol

Cat.No: T5S1285

Synonym: Falcarindiol,镰叶芹二醇

Target: Others

Thiamine monochloride

Cat.No: T2O2741

Synonym: Thiamine chloride,Vitamin B1

Target: Others, Antioxidant, Endogenous Metabolite, Antibacterial

Ethyl cinnamate

Cat.No: TN1624

Target: Calcium Channel, ROS, NO Synthase

Hederacolchiside E

Cat.No: TN1725

Synonym: 革叶常春藤皂苷E

Target: Beta Amyloid, ROS

4-Methyldaphnetin

Cat.No: TJS0315

Synonym: 7,8-Dihydroxy-4-methylcoumarin,4-甲基瑞香素,DHMC,7,8-二羟基-4-甲基香豆素

Target: Apoptosis, Lipoxygenase

gamma-Linolenic acid

Cat.No: T4868

Synonym: gamolenic acid,γ-Linolenic acid,γ-亚麻酸

Target: Endogenous Metabolite

Uric acid sodium

Cat.No: T41242

Target: Reactive Oxygen Species

Cat.No: T5S1097

Synonym: (R)-1,2-Dimethoxyaporphine,(-)-Neferine,甲基莲心碱

Target: Apoptosis, NF-κB, Autophagy

Cat.No: T2924

Synonym: 根皮素,Dihydronaringenin,NSC 407292,RJC 02792

Target: SGLT, transporter, Endogenous Metabolite

Cat.No: T5S0106

Synonym: 贝母辛,Ebeiensine

Target: RAAS, AChR

Cat.No: T31102

Synonym: NSC32984,Kryptocavin,Cryptocavine,Kryptopine,Cryptopin

6"-O-Acetyldaidzin

Cat.No: T13521

Target: Others

Cat.No: TN4406

Hispaglabridin A

Cat.No: T74202

4beta-Carboxy-19-nortotarol

Cat.No: TN3069

Target: NADPH-oxidase

Luteolin 5-O-glucoside

Cat.No: TN1896

Synonym: 藤黄菌素,Luteollin 5-glucoside,木犀草素-5-O-葡萄糖苷

Target: Others

Cat.No: T3S2210

Target: Others

Phyllostadimer A

Cat.No: TN4770

Target: Others

6"-O-Acetylgenistin

Cat.No: T14062

Target: Others

Dihydroisotanshinone I

Cat.No: TN1588

Synonym: 二氢异丹参酮I,二氢丹参酮

Target: ATPase, Potassium Channel, Calcium Channel

4-Ethylresorcinol

Cat.No: T40368

Cat.No: TN4388

Target: Antifection

Quercetin 3-O-rutinoside-7-O-glucoside

Cat.No: T81325

Quercetin 3,4'-dimethyl ether

Cat.No: TN4877

Target: ERK, BCL, MAPK, Caspase, JNK

Cat.No: TN4212

Target: COX, Antifection

3,4-Dihydroxy-2-methoxyxanthone

Cat.No: TN2876

Target: Antibacterial, Antifection

Cat.No: T82278

Broussochalcone A

Cat.No: T72594

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