1218
47
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T17870 |
cIAP1 ligand 1
E3 ligase Ligand 12 |
Others | Others |
cIAP1 ligand 1 (E3 ligase Ligand 12) 是基于 LCL161 衍生物的细胞凋亡蛋白配体,可募集 IAP 泛素连接酶以降解靶蛋白,可用于和雄激素受体配体偶联开发蛋白降解剂,可用于研究前列腺癌。 | |||
TP1484L |
α2β1 Integrin Ligand Peptide acetate
α2β1 Integrin Ligand Peptide acetate (134580-64-6) |
Integrin | Cytoskeletal Signaling |
α2β1 Integrin Ligand Peptide acetate (α2β1 Integrin Ligand Peptide acetate (134580-64-6)) 是 α2β1 整合素受体的潜在拮抗剂。它与细胞膜上的 α2β1 整合素受体相互作用,介导细胞外信号进入细胞。 | |||
T13510 |
Sigma-LIGAND-1
|
Sigma receptor | GPCR/G Protein |
Sigma-LIGAND-1 是一种选择性 sigma 受体配体,在 DTG 和 PPP 位点的 IC50 分别为 16 nM,19 nM。Sigma-LIGAND-1 对多巴胺 D2 受体的 Ki 为 4000 nM。 | |||
T10053 |
5HT6-ligand-1
|
5-HT Receptor | GPCR/G Protein; Neuroscience |
5HT6-ligand-1 是一种具有口服活性的 5-HT6 受体配体 (Ki = 1.43 nM)。 | |||
T5835 |
PROTAC ERRα ligand 2
|
Estrogen Receptor/ERR; Estrogen/progestogen Receptor | Endocrinology/Hormones |
PROTAC ERRα ligand 2 是雌激素相关受体 α (ERRα)反向激动剂。它对 ERRα (IC50=5.67 nM) 的抑制作用比 XCT790 (IC50=61.3 nM) 高效约 11 倍。 | |||
T15191 |
PROTAC ERRα ligand 1
|
Estrogen Receptor/ERR; Estrogen/progestogen Receptor | Endocrinology/Hormones |
PROTAC ERRα ligand 1 是一种雌激素相关受体 α (ERRα) 拮抗剂,能够作用于 ERRα (IC50:0.04 μM)和 ERRγ (IC50:2.8 μM)。 | |||
TP1496L |
p5 Ligand for Dnak and DnaJ acetate
p5 Ligand for Dnak and DnaJ acetate(209518-24-1 free base) |
HSP | Cytoskeletal Signaling; Metabolism |
p5 Ligand for Dnak and DnaJ acetate(209518-24-1 free base) 是一种九肽。它是 DnaK(大肠杆菌 Hsp70)和 DnaJ(大肠杆菌 Hsp40)的高亲和力配体。 | |||
T38476 |
Metallo β-lactamase ligand 1
|
Antibacterial | Microbiology/Virology |
Metallo β-lactamase ligand 1 是B 类β-内酰胺酶的抑制剂,具有抗菌活性。 | |||
T12551 |
PROTAC BRD4 ligand-1
|
Epigenetic Reader Domain; Ligands for Target Protein for PROTAC | Chromatin/Epigenetic; PROTAC |
PROTAC BRD4 ligand-1 是 PROTAC GNE-987 靶向 BRD4 蛋白的配体,也是一种 BET 的抑制剂。 | |||
T60015 |
TSPO ligand-2
Carbonic acid |
AUTACs | PROTAC |
TSPO ligand-2 (Carbonic acid) 是 AUTAC1 的配体,AUTAC1含有一个对氟苄基鸟嘌呤和一个烟曲霉醇部分。 | |||
T17879 |
E3 ligase Ligand 8
|
Others; Ligand for E3 Ligase | Others; PROTAC |
E3 ligase Ligand 8 是 E3 泛素连接酶配体。它能够利用 linker 与靶蛋白配体连接,形成 PROTAC 分子。PROTAC 可诱导促癌蛋白发生泛素化降解。 | |||
TP1704 |
Galanin Receptor Ligand M35 TFA
|
Neuropeptide Y Receptor | GPCR/G Protein; Neuroscience |
Galanin Receptor Ligand M35 TFA(142846-71-7 free base) 是一种高亲和力配体和甘丙肽受体拮抗剂 (Kd=0.1 nM)。 | |||
T9809 |
E3 ligase Ligand 23
|
Ligand for E3 Ligase | PROTAC |
E3 ligase Ligand 23 是一种 cereblon 结合剂,可通过泛素蛋白酶体降解 Ikaros 或 Aiolos。 | |||
T9360 |
CRBN ligand-9
2-(2,6-dioxopiperidin-3-yl)-5-nitroisoindoline-1,3-dione |
Ligand for E3 Ligase | PROTAC |
CRBN ligand-9 (2-(2,6-dioxopiperidin-3-yl)-5-nitroisoindoline-1,3-dione) 表现出对 CRBN 的抑制作用。 | |||
T13848 |
SMARCA-BD ligand 1 for Protac
|
Epigenetic Reader Domain | Chromatin/Epigenetic |
SMARCA-BD ligand 1 for Protac 能够与 BAF ATPase 亚基 SMARCA2 结合,可用于 PROTAC 技术,用于降解 SMARCA2。 | |||
T13890 |
SMARCA-BD ligand 1 for Protac dihydrochloride
|
Epigenetic Reader Domain | Chromatin/Epigenetic |
SMARCA-BD ligand 1 for Protac dihydrochloride 是一种能够与 BAF ATPase 亚基 SMARCA2 结合的化合物,基于 PROTAC 技术,使 SMARCA2 降解。 | |||
T7763 |
Thalidomide-4-OH
Cereblon ligand 2,E3 ligase Ligand 2 |
Ligand for E3 Ligase | PROTAC |
Thalidomide-4-OH (E3 ligase Ligand 2) 是一种基于 Thalidomide 的 Cereblon 配体,可用于募集 CRBN 蛋白。它能够利用 linker 与靶蛋白配体连接,得到 PROTAC 分子。 | |||
T39997 |
PROTAC CDK9 ligand-1
PROTAC CDK9 ligand-1 |
||
PROTAC CDK9 ligand-1 is a CDK9 ligand that can be used in the synthesis of PROTACs. | |||
T7752 |
(S,R,S)-AHPC-Me
VHL ligand 2,E3 ligase Ligand 1A |
Ligand for E3 Ligase | PROTAC |
(S,R,S)-AHPC-Me (E3 ligase Ligand 1A) 是基于 (S,R,S)-AHPC 的的 VHL 配体,可用于募集 von Hippel-Lindau (VHL) 蛋白。它可有效降解去势抵抗性前列腺癌细胞中的 BET 蛋白,DC50<1 nM。它可用于合成 ARV-771。 | |||
T13671 |
(S,R,S)-AHPC-Me hydrochloride
VHL ligand 2 hydrochloride,E3 ligase Ligand 1 |
Others; Ligand for E3 Ligase | Others; PROTAC |
(S,R,S)-AHPC-Me hydrochloride (VHL ligand 2 hydrochloride) is a chemical compound utilized in the synthesis of ARV-771, an exceptionally potent BET protein degrader. This compound selectively degrades BET protein in cells resistant to castration, exhibiting a remarkable DC50 <1 nM. Recognized as VHL ligand 2 hydrochloride, (S,R,S)-AHPC-Me hydrochloride serves as the VHL ligand derived from (S,R,S)-AHPC for the recruitment of von Hippel-Lindau (VHL) protein. | |||
T39628 |
PROTAC BRD4 ligand-2
PROTAC BRD4 ligand-2 |
||
PROTAC BRD4 ligand-2 is a ligand for target BRD4 protein for PROTAC CFT-2718. | |||
T7753 |
Thalidomide-O-COOH
Cereblon ligand 3,E3 ligase Ligand 3,TCE35031 |
Others; Ligand for E3 Ligase | Others; PROTAC |
Thalidomide-O-COOH (Cereblon ligand 3) 是一种基于 Thalidomide 的 Cereblon 配体,可用于募集 CRBN 蛋白。它能够利用 linker 与靶蛋白配体连接,得到 PROTAC 分子。 | |||
T17869 |
cIAP1 ligand 2
E3 ligase Ligand 11 |
Others | Others |
cIAP1 ligand 2, a derivative of LCL161, is an IAP ligand that can be connected to the ABL ligand for protein via a linker, resulting in the formation of SNIPER. | |||
T39629 |
BRD4 ligand-Linker Conjugate 1
BRD4 ligand-Linker Conjugate 1 |
||
BRD4 Ligand-Linker Conjugate 1 is a compound consisting of a ligand and a linker, specifically designed to bind to the target protein BRD4. This conjugate serves as a valuable tool for synthesizing PROTACs, molecules utilized for targeted protein degradation. | |||
T17877 |
VH032-cyclopropane-F
VHL ligand 3,E3 ligase Ligand 19,Phenolic VH101 |
Others; Ligand for E3 Ligase | Others; PROTAC |
VH032-cyclopropane-F (Phenolic VH101) 是基于 VH032 的 VHL 配体。它能够利用 linker 与靶蛋白配体连接,得到 PROTAC 分子,如 PROTAC 1。PROTAC 1 是 SMARCA2 和 SMARCA4 的部分降解剂。 | |||
T17916 |
Pomalidomide-PEG4-C2-NH2
Cereblon Ligand-Linker Conjugates 8,E3 Ligase Ligand-Linker Conjugates 22 |
Others; Ligand for E3 Ligase | Others; PROTAC |
Pomalidomide-PEG4-C2-NH2 (E3 Ligase Ligand-Linker Conjugates 22) 是一种合成的 E3 连接酶配体- linker 偶联物,用于 PROTAC 技术中。 | |||
T73599 |
TSPO ligand-1
|
Autophagy | Autophagy |
TSPO ligand-1 对外周和中枢苯二氮卓受体有亲和力。TSPO ligand-1 是一种线粒体外膜跨膜结构域上与 AUTAC4 结合的蛋白,可诱导线粒体自噬 (autophagy) 促进胞内线粒体更新。TSPO ligand-1 参与胆固醇在胞内的转运,可作为脑损伤和神经变性的生物标志物。 | |||
T39609 |
cIAP1 Ligand-Linker Conjugates 16
cIAP1 Ligand-Linker Conjugates 16 |
||
cIAP1 Ligand-Linker Conjugates 16 refers to a specific type of ligase ligand-linker conjugate, possessing the ability to engage with E3 ligases, which finds application in the synthesis of PROTACs. | |||
T17325 |
Pomalidomide-PEG4-C-COOH
Cereblon Ligand -Linker Conjugates 1,E3 Ligase Ligand-Linker Conjugates 1 |
Others; E3 Ligase Ligand-Linker Conjugate | Others; PROTAC |
Pomalidomide-PEG4-C-COOH (E3 Ligase Ligand-Linker Conjugates 1) 包含基于 Pomalidomide 的 cereblon 配体和 4 个单元 PEG linker,是一种合成的 E3 连接酶配体-linker 偶联物。 | |||
T15189 |
Thalidomide-O-amido-C4-N3
E3 ligase Ligand-Linker Conjugates 18,Cereblon Ligand-Linker Conjugates 4 |
Others; Ligand for E3 Ligase | Others; PROTAC |
Thalidomide-O-amido-C4-N3 (Cereblon Ligand-Linker Conjugates 4) 是一种 E3 连接酶配体- linker 偶联物,包含基于 Thalidomide 的 cereblon 配体和 linker。 | |||
T17919 |
Thalidomide-O-amido-C6-NH2 TFA
E3 Ligase Ligand-Linker Conjugates 25 Trifluoroacetate,Cereblon Ligand-Linker Conjugates 11 TFA,E3 Ligase Ligand-Linker Conjugates 25 TFA |
Others; Ligand for E3 Ligase | Others; PROTAC |
Thalidomide-O-amido-C6-NH2 TFA (Cereblon Ligand-Linker Conjugates 11 TFA) 包含基于 Thalidomide 的 cereblon 配体和 1 个 linker,是一种合成的 E3 连接酶配体-linker 偶联物。可用于 PROTAC 的合成分子。 | |||
T40142 |
Thalidomide-NH-CBP/p300 ligand 2
Thalidomide-NH-CBP/p300 ligand 2 |
||
Thalidomide-NH-CBP/p300 ligand 2 (P-007) is a PROTAC-based compound designed to degrade CBP and p300, acting as a functional antagonist (WO2020173440). | |||
T7760 |
Thalidomide-O-amido-C3-NH2 TFA
Cereblon Ligand-Linker Conjugates 16 TFA,E3 Ligase Ligand-Linker Conjugates 52 TFA |
E3 Ligase Ligand-Linker Conjugate; Ligand for E3 Ligase | PROTAC |
Thalidomide-O-amido-C3-NH2 TFA (Cereblon Ligand-Linker Conjugates 16 TFA) 包含基于 Thalidomide 的 cereblon 配体和 1 个 linker,是一种合成的 E3 连接酶配体-linker 偶联物,。 | |||
T7759 |
Thalidomide-O-amido-C4-NH2 TFA
E3 ligase Ligand-Linker Conjugates 19 TFA,Cereblon Ligand-Linker Conjugates 6 TFA |
E3 Ligase Ligand-Linker Conjugate | PROTAC |
Thalidomide-O-amido-C4-NH2 TFA (E3 ligase Ligand-Linker Conjugates 19 TFA) 包含基于 Thalidomide 的 cereblon 配体和 1 个 linker,是一种合成的 E3 连接酶配体-linker 偶联物。 | |||
T7758 |
Thalidomide-O-amido-PEG3-C2-NH2 TFA
E3 ligase Ligand-Linker Conjugates 14 TFA,Cereblon Ligand-Linker Conjugates 3 (TFA) |
Others; E3 Ligase Ligand-Linker Conjugate; Ligand for E3 Ligase | Others; PROTAC |
Thalidomide-O-amido-PEG3-C2-NH2 TFA (Cereblon Ligand-Linker Conjugates 3 (TFA)) 包含基于 Thalidomide 的 cereblon 配体和 3 个单元的 PEG linker,是一种合成的 E3 连接酶配体-linker 偶联物。 | |||
T17918 |
Thalidomide-O-amido-PEG2-C2-NH2 TFA
E3 Ligase Ligand-Linker Conjugates 24 TFA,Cereblon Ligand-Linker Conjugates 10 TFA |
Others; E3 Ligase Ligand-Linker Conjugate | Others; PROTAC |
Thalidomide-O-amido-PEG2-C2-NH2 TFA (E3 Ligase Ligand-Linker Conjugates 24 TFA) 包含基于 Thalidomide 的 cereblon 配体和 2 个单元的 PEG linker,是一种合成的 E3 连接酶配体-linker 偶联物。 | |||
T17922 |
(S,R,S)-AHPC-PEG3-NH2 hydrochloride
VHL Ligand-Linker Conjugates 1 hydrochloride,E3 ligase Ligand-Linker Conjugates 5,VH032-PEG3-NH2 hydrochloride,VHL Ligand-Linker Conjugates 1 HCl |
Others; E3 Ligase Ligand-Linker Conjugate | Others; PROTAC |
(S,R,S)-AHPC-PEG3-NH2 hydrochloride (E3 ligase Ligand-Linker Conjugates 5) 是一种 E3 ligase ligand-linker conjugate,包含了 (S,R,S)-AHPC-based VHL ligand 和 3-unit PEG linker。 | |||
T82174 |
hRIO2 kinase ligand-1
|
Others | Others |
hRIO2 kinase ligand-1 是一种有效的 hRIO2 激酶的配体(Kd:520 nM)。 | |||
T17921 |
(S,R,S)-AHPC-PEG4-N3
VH032-PEG4-N3,VHL Ligand-Linker Conjugates 5,E3 ligase Ligand-Linker Conjugates 4 |
Others; PROTAC Linker | Others; PROTAC |
(S,R,S)-AHPC-PEG4-N3 (VHL Ligand-Linker Conjugates 5) is a synthesized conjugate that functions as a ligand-linker in E3 ligase-based systems. It is composed of the (S,R,S)-AHPC VHL ligand and a 4-unit PEG linker, both commonly employed in PROTAC technology. | |||
T39440 |
CXCL12 ligand 1
|
||
CXCL12 ligand 1 is the first ligand of the sY12-binding pocket on chemokine CXCL12 . | |||
T17920 |
(S,R,S)-AHPC-PEG1-N3
VHL Ligand-Linker Conjugates 9,VH032-PEG1-N3,E3 ligase Ligand-Linker Conjugates 3 |
Others; Ligand for E3 Ligase | Others; PROTAC |
(S,R,S)-AHPC-PEG1-N3 (E3 ligase Ligand-Linker Conjugates 3) 是 E3 连接酶配体和linker 连接得到的 偶联物,包含基于 (S,R,S)-AHPC 的 VHL 配体和 1 个单元 PEG linker。 | |||
T17909 |
(S,R,S)-AHPC-PEG3-N3
VHL Ligand-Linker Conjugates 8,VH032-PEG3-N3,E3 ligase Ligand-Linker Conjugates 12 |
Others; E3 Ligase Ligand-Linker Conjugate; Ligand for E3 Ligase | Others; PROTAC |
(S,R,S)-AHPC-PEG3-N3 (VHL Ligand-Linker Conjugates 8) 包含基于 (S,R,S)-AHPC 的 VHL 配体和 3 个单元 PEG linker,是一种合成的 E3 连接酶配体-linker 偶联物。 | |||
T17889 |
cIAP1 Ligand-Linker Conjugates 14
E3 ligase Ligand-Linker Conjugates 36 |
Others | Others |
cIAP1 Ligand-Linker Conjugates 14 consist of an IAP ligand that targets the E3 ubiquitin ligase and a PROTAC linker. These conjugates, known as cIAP1 Ligand-Linker Conjugates 14, are used in the development of SNIPERs[1]. | |||
T17896 |
cIAP1 Ligand-Linker Conjugates 4
E3 ligase Ligand-Linker Conjugates 42 |
Others | Others |
cIAP1 Ligand-Linker Conjugates 4 is a chemical compound that comprises an IAP ligand specifically designed for the E3 ubiquitin ligase and a PROTAC linker. This compound, cIAP1 Ligand-Linker Conjugates 4, has the potential to be utilized in the development of SNIPERs[1]. | |||
T17885 |
cIAP1 Ligand-Linker Conjugates 11
E3 ligase Ligand-Linker Conjugates 33 |
Others | Others |
cIAP1 Ligand-Linker Conjugates 11 is a chemical compound that combines an IAP ligand specifically designed for the E3 ubiquitin ligase with a PROTAC linker. This compound, cIAP1 Ligand-Linker Conjugates 11, is useful in the development of SNIPERs[1], allowing for the targeted degradation of proteins. | |||
T17891 |
cIAP1 Ligand-Linker Conjugates 2
E3 ligase Ligand-Linker Conjugates 37 |
Others | Others |
cIAP1 Ligand-Linker Conjugates 2 is a chemical compound that combines an IAP ligand for the E3 ubiquitin ligase with a PROTAC linker. This compound is particularly useful in the design of SNIPERs [1]. | |||
T17893 |
cIAP1 Ligand-Linker Conjugates 5
E3 ligase Ligand-Linker Conjugates 39 |
Others | Others |
cIAP1 Ligand-Linker Conjugates 5 is a chemical compound consisting of an IAP ligand that targets the E3 ubiquitin ligase, and a PROTAC linker. This compound, cIAP1 Ligand-Linker Conjugates 5, is specifically designed for the development of SNIPERs[1]. | |||
T18640 |
(S,R,S)-AHPC-C4-NH2 hydrochloride
VH032-C4-NH2 hydrochloride,E3 ligase Ligand-Linker Conjugates 28,VHL Ligand-Linker Conjugates 13 |
Others; Ligand for E3 Ligase | Others; PROTAC |
(S,R,S)-AHPC-C4-NH2 hydrochloride (E3 ligase Ligand-Linker Conjugates 28) 是一种合成的 E3 连接酶配体- linker 偶联物,包含基于 (S,R,S)-AHPC 的 VHL 配体和 linker。 | |||
T17908 |
VHL Ligand-Linker Conjugates 15
E3 Ligase Ligand-Linker Conjugates 56 |
Others | Others |
VHL Ligand-Linker Conjugates 15 is a chemical compound that combines a VHL ligand, which targets the E3 ubiquitin ligase, with a PROTAC linker. It is specifically designed for the creation of PROTACs[1]. | |||
T15190L |
(S,R,S)-AHPC-PEG4-NH2
VHL Ligand-Linker Conjugates 4,E3 ligase Ligand-Linker Conjugates 7 Free Base,VH032-PEG4-NH2 |
Others; Ligand for E3 Ligase | Others; PROTAC |
(S,R,S)-AHPC-PEG4-NH2 (VHL Ligand-Linker Conjugates 4) 是一种合成的 E3 连接酶配体-接头偶联物,包含基于 (S,R,S)-AHPC 的 VHL 配体和 4 单元 PEG 接头。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T24729 |
Roseoflavin
|
Antibacterial | Microbiology/Virology |
Roseoflavin 是天然色素,起初分离自Streptomyces davawensis。Roseoflavin 是核黄素和黄素单核苷酸的抗代谢类似物,显示出抗菌活性。 | |||
TQ0176 |
(-)-Isocorypalmine
Tetrahydrocolumbamine,(-)-异延胡索单酚碱,(S)-Tetrahydrocolumbamine |
Dopamine Receptor; Antifungal | GPCR/G Protein; Microbiology/Virology; Neuroscience |
(-)-Isocorypalmine ((S)-Tetrahydrocolumbamine) 是一种多巴胺受体配体,从延胡索粗碱中分离得到。重组CYP719A21 对 (-)-Isocorypalmine 具有严格的底物特异性和高亲和力 (Km=4.63 μM)。 | |||
T8097 |
Methyl 3-aminopropanoate hydrochloride
β-Alanine methyl ester hydrochloride,3-氨基丙酸甲酯盐酸盐 |
Others | Others |
Methyl 3-aminopropanoate hydrochloride (β-Alanine methyl ester hydrochloride) 是由 Β-Alanine (I) 酯化得到。它可用于合成双齿吡啶酸配体。 | |||
T14063 |
7α,25-Dihydroxycholesterol
7α,25-OHC |
EBI2/GPR183; Endogenous Metabolite | GPCR/G Protein; Metabolism |
7α,25-Dihydroxycholesterol 是一种孤儿 GPCR 受体EBI2 (GPR183)的内源性配体和有效选择性激动剂。它对激活 EBI2 有很强的作用 (EC50=140 pM;Kd=450 pM)。它能够作为一种趋化因子,指导 B 细胞、T 细胞和树突状细胞的迁移。 | |||
T4S0039 |
Baimaside
白麻苷,Quercetin-3-O-sophoroside,Quercetin 3-beta-D-sophoroside |
Others | Others |
Baimaside (Quercetin-3-O-sophoroside) 是一种超氧阴离子的清除剂,分离自A. venetum 的花中。 | |||
TN1023 |
Miltirone
|
P450; GABA Receptor | Membrane transporter/Ion channel; Metabolism; Neuroscience |
Miltirone 是存在于丹参中的一种天然产物,可作为中枢苯二氮受体部分激动剂,IC50值为 0.3 μM。 | |||
TP1232L |
Amylin, amide, rat acetate(124447-81-0,free base)
|
Amylin Receptor | GPCR/G Protein |
Amylin, amide, rat acetate(124447-81-0,free base) 是 AMY1 和 AMY3 受体以及 AMY2 受体的强效和高亲和力配体。 | |||
TN2077 |
(+/-)-Pinocembrin
NSC 43318,(±)-5,7-Dihydroxyflavanone |
GPR; Others | Endocrinology/Hormones; GPCR/G Protein; Others |
(+/-)-Pinocembrin (NSC-43318) 是一种来自腋松的天然产物,它是一种 GPR120 配体,能促进 HaCaT 细胞系的伤口愈合。 | |||
T3806 |
kaempferide
Kaempferol 4'-O-methyl ether,山奈素,Kaempferol 4'-methyl ether,4'-Methylkaempferol,4'-O-Methylkaempferol |
Estrogen Receptor/ERR; Estrogen/progestogen Receptor; Influenza Virus; Antibacterial; Autophagy | Autophagy; Endocrinology/Hormones; Microbiology/Virology |
kaempferide (4'-Methylkaempferol) 是一种存在于山柰中的O-甲基化黄酮醇,具有抗病毒活性。 | |||
T13815 |
Penicillic acid
|
Apoptosis; Caspase; Antibacterial; Antibiotic | Apoptosis; Microbiology/Virology; Proteases/Proteasome |
Penicillic acid, a polyketide mycotoxin, synthesized by various species of Aspergillus and Penicillium, acts as an inhibitor of Fas ligand-induced apoptosis by impeding self-processing of caspase-8. Additionally, in vitro studies have shown that Penicillic acid displays cytotoxic properties in rat alveolar macrophages. | |||
T8363 |
DL-Serine
|
PKM | Metabolism |
DL-Serine 是 D-丝氨酸和 L-丝氨酸的混合物,是一种基础代谢物。它具有抗病毒作用,能抑制烟草花叶病毒的增殖。 | |||
Fr12596 |
3-Acetylcoumarin
|
Others | Others |
3-Acetylcoumarin 作为室温下铜催化 CN 偶联反应的实用配体。它具有神经保护和杀螨特性。 | |||
T5026 |
Oxytocin
催产素,α-Hypophamine,Oxytocic hormone,Oxytocin (Syntocinon) |
Oxytocin Receptor | Endocrinology/Hormones; GPCR/G Protein |
Oxytocin (Oxytocin (Syntocinon)) 是哺乳动物的神经垂体激素,是多效的下丘脑肽,是催产素受体的配体,有助于分娩、哺乳和亲社会行为。它可作为一种压力应对分子,具有抗炎、抗氧化剂和保护作用。 | |||
TJS1183 |
Cyclen
轮环藤宁,1,4,7,10-tetraazacyclododecane |
Others | Others |
Cyclen (1,4,7,10-tetraazacyclododecane) 是一种氮杂冠醚的类似物,是制备有效的大环螯合物的中间体,是制备磁共振造影剂的前体物质。 | |||
TN3209 |
3′,4′,7-Trihydroxyflavone
|
ATPase; Others; p38 MAPK; NF-κB | MAPK; Membrane transporter/Ion channel; NF-κB; Others |
3',4',7-Trihydroxyflavone 是分离自蚕豆荚的黄酮苷元化合物。 | |||
T5145 |
Oxytocin acetate
Oxytocic hormone acetate,α-Hypophamine acetate,Oxytocin acetate (50-56-6 free base),醋酸催产素 |
Oxytocin Receptor | Endocrinology/Hormones; GPCR/G Protein |
Oxytocin acetate (α-Hypophamine acetate) 是哺乳动物的神经垂体激素,是多效的下丘脑肽,是催产素受体的配体,有助于分娩、哺乳和亲社会行为。它可作为一种压力应对分子,具有抗炎、抗氧化剂和保护作用。 | |||
T3S0738 |
yangonin
Y100550,甲氧醉椒素 |
Cannabinoid Receptor; NF-κB; Autophagy | Autophagy; GPCR/G Protein; NF-κB |
Yangonin (Y100550) 是一种新型 CB1 受体配体,对人重组 CB1 受体具有亲和力。它可能是干预 NF-κB 依赖性病理状况的候选药物。 | |||
T36857 |
Estrone sulfate sodium
雌酮3-硫酸钠,Estrone 3-sulfate (sodium salt),17β-Estrone 3-sulfate |
Endogenous Metabolite | Metabolism |
Estrone sulfate sodium (17β-Estrone 3-sulfate) 是一种主要的循环血浆雌激素,无生物活性,通过类固醇硫酸酯酶(STS) 转化为生物活性雌激素雌酮。 | |||
T15705 |
Laminaran
β-1,3-Glucan |
||
Laminaran 是一种从褐藻中分离出来的 β-1-3-葡聚糖,常作为 Dectin-1 的典型配体,具有抗癌、免疫调节和辐射防护作用。 Laminaran 可被葡糖酶催化。Laminaran 在体内外实验中显示出抗肿瘤活性,可用于预防和治疗癌症。 | |||
T7998 |
1,7-Diaminoheptane
|
Others | Others |
1,7-Diaminoheptane 是一种脂族胺家族的化合物。它可用于合成肽、拟肽和其他化合物,也被用作酶反应中的底物,金属配合物中的配体,以及有机合成中的试剂。 | |||
TN2143 |
3,7,4'-Trihydroxyflavone
Resokaempferol,5-Deoxykampferol |
DNA | DNA Damage/DNA Repair |
3,7,4'-Trihydroxyflavone(5-Deoxykampferol) 是从黄檀心材中分离得到的一种具有 DNA 断链活性的黄酮类化合物,可抑制 NF-κB 配体 (RANKL) 受体激活剂诱导的 RAW 264.7 细胞和骨髓巨噬细胞中的破骨细胞分化、肌动蛋白环形成和骨吸收。 | |||
T4973 |
Paraxanthine
1,7-二甲基黄嘌呤,1,7-DIMETHYLXANTHINE |
Endogenous Metabolite | Metabolism |
Paraxanthine (1,7-dimethylxanthine) 是一种 caffeine 的代谢物,能够刺激Ryanodine 受体通道来抑制多巴胺能细胞的死亡。 | |||
TL0005 |
3,5-O-Dicaffeoylquinic acid
Isochlorogenic Acid A,(-)-3,5-二咖啡酰奎宁酸,(-)-3,5-Dicaffeoyl quinic acid,3,5-Dicaffeoylquinic Acid |
Others | Others |
3,5-O-Dicaffeoylquinic acid (Isochlorogenic Acid A) 能够改善由三甲基锡诱导的学习和记忆缺陷。 | |||
T0034 |
Cortisone acetate
醋酸可的松,Cortisone 21-acetate,NSC 49420 |
Glucocorticoid Receptor; Endogenous Metabolite | Endocrinology/Hormones; Metabolism |
Cortisone acetate (NSC-49420) 是 Cortisol(一种糖皮质激素)的氧化代谢产物。它在高浓度下能够部分干预 Glucocorticoid 与Glucocorticoid-receptor 的结合。它具有免疫抑制和消炎的作用。 | |||
TN6694 |
5,6-Benzoflavone
β-Naphthoflavone,beta-NF |
Antioxidant | oxidation-reduction |
5,6-Benzoflavone (β-Naphthoflavone) 是芳烃受体的外源配体,可破坏人肝癌 HepG2 细胞中的锌稳态。5,6-Benzoflavone (β-Naphthoflavone) 具有抗炎和抗氧化活性,抑制通过 AKT/Nrf-2/HO-1-NF-kappaB 信号转导轴,抑制 LPS 诱导的炎症,抑制TNF-α诱导的ICAM-1和VCAM-1表达,可用于研究神经退行性疾病。 | |||
T2915 |
Bardoxolone
RTA 401,齐墩果烷三萜化合物,CDDO |
Others; Nrf2 | Immunology/Inflammation; Others |
Bardoxolone (CDDO) 是新型核调节因子激活剂。 | |||
T1168 |
Desonide
Tridesilon,地索奈德,Locapred,Prednacinolone |
Glucocorticoid Receptor | Endocrinology/Hormones |
Desonide (Prednacinolone) 是一种非氟化皮质类固醇抗炎剂,能够作用于糖皮质激素受体。 | |||
T4S0498 |
Glaucocalyxin A
蓝萼甲素,Wangzaozin B,Leukamenin F |
Apoptosis; Akt; Caspase; PI3K | Apoptosis; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Proteases/Proteasome |
Glaucocalyxin A (Leukamenin F) 是来自日本黑纹病菌的一种对映型月桂基二萜,具有抗肿瘤作用。它通过调节PI3K/Akt 信号通路抑制 GLI1 的核易位,诱导骨肉瘤凋亡。 | |||
T37974 |
(S)-Coriolic acid
13(S)-HODE |
Lipoxygenase; Mitochondrial Metabolism; PPAR | DNA Damage/DNA Repair; Metabolism |
(S)-Coriolic acid (13(S)-HODE) 是一种重要的细胞内信号剂,是亚油酸与植物和哺乳动物脂氧合酶反应生成的,在各种生物系统中参与细胞增殖和分化。(S)-Coriolic acid 在 1 μM 左右时,它能抑制肿瘤细胞与血管内皮的粘附,能下调 IRGpIIb/IIIa 受体的表达。(S)-Coriolic acid 是15-脂氧合酶 (15-LOX) 代谢产物,常作为内源性配体激活 PPARγ。(S)-Coriolic acid 诱导线粒体功能障碍 和气道上皮损伤。 | |||
T0798 |
Triamcinolone
Fluoxyprednisolone,曲安西龙,Aristocort,Rodinolone |
Glucocorticoid Receptor; COX | Endocrinology/Hormones; Immunology/Inflammation; Neuroscience |
Triamcinolone (Aristocort) 是一种皮质类固醇激素受体激动剂,也是一种合成的长效糖皮质激素,具有抗炎活性。 | |||
T14011 |
2-Arachidonoylglycerol
|
Cannabinoid Receptor; Endogenous Metabolite | GPCR/G Protein; Metabolism |
2-Arachidonoylglycerol 属于人内源性代谢物,是中枢神经系统中的一种内源性大麻素配体。 | |||
T4938 |
Potassium 1H-indol-3-yl sulfate
硫酸吲哚钾盐,Indoxyl sulfate potassium salt,Potassium 3-indoxyl sulfate |
AhR; Endogenous Metabolite | Immunology/Inflammation; Metabolism |
Potassium 1H-indol-3-yl sulfate (Potassium 3-indoxyl sulfate) 是人芳烃受体(AhR)的激动剂。芳烃受体(AhR)最近被发现是免疫炎症条件的病理生理调节剂,Potassium 1H-indol-3-yl sulfate 已被证明是AhR的配体。Potassium 1H-indol-3-yl sulfate 也是膳食蛋白质中色氨酸的代谢物。色氨酸被肠道细菌代谢为吲哚,吲哚被吸收到血液中,然后在肝脏中进一步代谢为硫酸吲哚,通常通过尿液排出体外。在肾功能受损的慢性肾病患者中,Potassium 1H-indol-3-yl sulfate 可作为尿毒症毒素在血清中积累,诱导氧化应激并加速疾病进展。250 μM Potassium 1H-indol-3-yl sulfate 可诱导NF-Κb活化,促进大鼠近端小管细胞TGF-β1和Smad3的表达,与促纤维化活性相关。 | |||
T13735 |
Imidazoleacetic acid
Imidazolyl-4-acetic acid |
Others | Others |
Imidazoleacetic acid, an endogenous ligand, stimulates imidazole receptors. | |||
T38468 |
Glycodeoxycholic acid monohydrate
|
||
Glycodeoxycholic acid monohydrate is a nuclear receptor ligand. | |||
T10821 |
Cirsiliol
|
Lipoxygenase | Metabolism |
Cirsiliol is a selective inhibitor of 5-lipoxygenase and a competitive low-affinity ligand of benzodiazepine receptors. | |||
T16846 |
Sauristolactam
Saurolactam |
Others | Others |
Sauristolactam inhibits the receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclastogenesis and has the potential to inhibit osteoclast differentiation. Sauristolactam, a natural aristolactam isolated from aerial portions of Saururus Chi | |||
TN4628 |
Nelumol A
|
FXR | Metabolism |
Nelumol A, and nelumal A show a potency comparable to the endogenous ligand, they may as a valuable potential novel lead compound in the search for FXR agonists. | |||
TN1484 |
Cheilanthifoline
|
NF-κB; Antifection | Microbiology/Virology; NF-κB |
Cheilanthifoline has anti-osteoclastogenic property, it gives significant inhibitions on receptor activator of nuclear factor-κB ligand-induced differentiation of mouse bone marrow-derived macrophages into multinucleated osteoclasts. | |||
T75682 | Cortisol sulfate | ||
Cortisol sulfate (Cortisol 21-sulfate) 是皮质醇 的一种代谢物。Cortisol sulfate 是细胞内运皮质激素蛋白的一种特异性配体。 | |||
T82578 |
Desacetylxanthanol
|
||
Desacetylxanthanol (Compound 4),源自Xanthium strumarium的倍半萜类化合物,展现出抗肿瘤坏死因子相关凋亡诱导配体(TRAIL)活性。 | |||
T21577 |
Narasin (sodium salt)
Naracin sodium salt,naransin sodium,海南霉素,HainanMycin |
NF-κB | NF-κB |
Narasin (sodium salt) (HainanMycin) 通过神经胶质瘤细胞中的 ER 应激诱导肿瘤坏死因子相关凋亡诱导配体 (TRAIL) 介导的细胞凋亡,并通过抑制 IκBα 的磷酸化来抑制 NF-κB 信号传导。 | |||
TN3537 |
Braylin
|
IL Receptor; TNF; NF-κB | Apoptosis; Immunology/Inflammation; NF-κB |
Braylin has anti-inflammatory, antinociceptive and immunomodulatory effects, which possibly act through the glucocorticoid receptor activation and by inhibition of the transcriptional activity of NF-κB. Braylin is also a phosphodiesterase-4 inhibitor, it could represent an ideal prototype of glucocorticoid receptor ligand, able to induce synergic immunomodulatory effects. | |||
T21500 |
Sphingosine-1-phosphate
S1P |
Endogenous Metabolite; S1P Receptor; LPL Receptor | GPCR/G Protein; Metabolism |
Sphingosine-1-phosphate (S1P) 是 S1P1-5 受体 (S1P1-5 receptors) 的激动剂和 GPR3、GPR6、GPR12 的配体。Sphingosine-1-phosphate 是细胞内的第二信使,动员 Ca2+ 作为 G 蛋白偶联受体的细胞外配体。Sphingosine-1-phosphate 是由鞘磷脂 (HY-113498) 或其他膜磷脂生成的重要脂质介质。 | |||
T82572 |
D-Glucosyl-β-1,1′-N-palmitoylsphingosine
C16 Glucosyl(β) Ceramide (d18:1/16:0) |
||
D-Glucosyl-β-1,1′-N-palmitoylsphingosine (C16 Glucosyl(β) Ceramide (d18:1/16:0)) 是内源性Mincle配体,具免疫刺激活性。 | |||
TN4383 |
Kazinol U
|
IL Receptor; IκB/IKK; NOS; NF-κB | Immunology/Inflammation; NF-κB |
Kazinol U may have therapeutic value in delaying pancreatic β-cell destruction in type 1 diabetes by blocking the NF-κB pathway in pancreatic β-cells reduces cell damage. Kazinol U shows estrogenic activity with ligand-activity of estrogen receptor, transcriptional activity of estrogen -responsive element-reporter genes, it may have beneficial effects in the treatment of menopausal symptoms. | |||
TN3539 | Broussonin A | ERK; IL Receptor; IκB/IKK; NOS; NF-κB; Akt | Cytoskeletal Signaling; Immunology/Inflammation; MAPK; NF-κB; PI3K/Akt/mTOR signaling |
Broussonins A and B, new phytoalexins from diseased paper mulberry. Broussonin A shows estrogenic activity with ligand-binding activity of estrogen receptor, transcriptional activity of estrogen-responsive element-luciferase reporter genes. Broussonin A c | |||
T36563 |
(E)-Guggulsterone
|
||
Bile acids are essential for solubilization and transport of dietary lipids, are the major products of cholesterol catabolism, and are physiological ligands for farnesoid X receptor (FXR), a nuclear receptor that regulates genes involved in lipid metabolism.1They are also inherently cytotoxic, as physiological imbalance contributes to increased oxidative stress.2,3Bile acid-controlled signaling pathways are promising novel targets to treat such metabolic diseases as obesity, type II diabetes, hy... |