46
24
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T12579 |
RAMB4
PTP1B-IN-9 |
Proteasome | Proteases/Proteasome; Ubiquitination |
RAMB4 (PTP1B-IN-9) 是一种泛素-蛋白酶体系统(UPS)应激源,是通过抑制 20S 蛋白酶体催化活性物质上游泛素介导的蛋白质降解而产生。它能够在不影响 20S 蛋白酶体催化活性的情况下触发泛素蛋白酶体系统 (UPS) 应激反应。 | |||
T0023 |
Valethamate bromide
Ediposin,Epidozin,戊沙溴铵,Epidosin,Resitan |
Others | Others |
Valethamate bromide (Resitan) 是快速作用的抗胆碱能解痉和肌萎缩剂,是一种酯,能够改善宫颈扩张加速分娩。 | |||
T20029 |
Buformin hydrochloride
NSC528218,NSC-528218,盐酸丁双胍,NSC 528218 |
AMPK | Chromatin/Epigenetic; PI3K/Akt/mTOR signaling |
Buformin hydrochloride (NSC-528218) 是一种有效的 AMPK 激活剂,是一种双胍类的口服抗糖尿病药物。Buformin 延缓胃肠道对葡萄糖的吸收,增加胰岛素敏感性和葡萄糖对细胞的吸收,并抑制肝脏对葡萄糖的合成。Buformin 也具有抗癌活性,可用于各种癌症研究。 | |||
T22450 |
Tyrphostin B44, (+) enantiomer
酪氨酸磷酸化抑制剂AG 835 |
EGFR | Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
Tyrphostin B44, (+) enantiomer 是一种表皮生长因子受体 (EGFR) 激酶抑制剂,IC50 为 0.86 μM,活性低于 (-) 对映体。 | |||
TP1554L |
HPV16 E7 (86-93) acetate
HPV16 E7 (86-93) acetate(160212-93-1 Free base) |
Others | Others |
HPV16 E7 (86-93) acetate 是人源白细胞抗原 A2.1 限制性 HPV16 E7 的衍生肽,在宫颈癌中具有免疫原性。 | |||
T23867 |
Cdc7-IN-7c
Cdc7 inhibitor-7c,Cdc7 inhibitor 7c,Cdc7 IN 7c |
CDK | Cell Cycle/Checkpoint |
Cdc7-IN-7c (Cdc7 inhibitor-7c) 具有抗肿瘤活性,对肝癌,肺癌,肾癌,脑癌,宫颈癌有抑制作用。 | |||
T27612 |
INI-43
INI 43,INI43 |
Others | Others |
INI-43 是Nuclear Import-43 的抑制剂,通过靶向 Kpnβ1 对各种宫颈和食管癌细胞系显示出显着的细胞毒性作用,并干扰 Kpnβ1 和已知的 Kpnβ1 cargo 蛋白、NFAT、NFκB、AP-1和NFY 的核定位。 | |||
T20742 |
TG-89
|
FLT; c-RET; JAK | Angiogenesis; Apoptosis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors |
TG-89是 JAK2、JAK3、RET 和 FLT3的抑制剂,对 JAK2的 IC50值为11.2 μM,在卵巢癌和宫颈癌的治疗中显示出抗癌活性。 | |||
T6858 |
Hydroxyprogesterone caproate
Primolut Depot,Delalutin,Hormofort,己酸孕酮,17α-Hydroxyprogesterone hexanoate,17α-Hydroxyprogesterone caproate |
Autophagy | Autophagy |
Hydroxyprogesterone caproate (Delalutin) 是一种甾体,是一种人工合成的孕激素。 | |||
TP1283L |
VIP(6-28)(human, rat, porcine, bovine) acetate
|
Others | Others |
VIP(6-28)(human, rat, porcine, bovine) acetate 是外源性血管活性肠肽 (VIP) 受体对颈上神经节 (SCG) 中 cAMP 作用的拮抗剂。 | |||
T9939 |
JMJD6 inhibitor WL12
2H-1-Benzopyran-2-one, 3-(3H-imidazo[4,5-c]pyridin-2-yl)-6-methyl-,ZINC6733033 |
Others | Others |
JMJD6 inhibitor WL12 (ZINC6733033) 是一种JMJD6 抑制剂,能够抑制JMJD6依赖的癌细胞增殖,包括宫颈癌细胞和肝癌细胞,为研究JMJD6在癌症发展中的生物学功能提供了一个小分子探针。 | |||
T67786 |
ABI-1968 PM
|
||
ABI-1968 PM 是ABI-1968的一种衍生物。ABI-1968是一种细胞凋亡刺激剂,是一种病毒复制抑制剂。ABI-1968可用于研究宫颈上皮内瘤样病变、乳头状瘤病毒感染和鳞状上皮内病变。 | |||
T60485 |
DIF-3
|
||
DIF-3 is a chemical compound that acts by activating GSK-3β to facilitate the degradation of cyclin D1 and c-Myc, resulting in reduced expression levels of these proteins. In addition, DIF-3 inhibits Wnt/β-catenin signaling pathway-related proteins in DLD-1 cells. This compound exerts a potent antiproliferative effect on the HeLa human cervical cancer cell line by inducing cyclin D1 degradation and inhibiting cyclin D1 mRNA expression [1]. | |||
T16773 |
Ro 90-7501
RO-90-7501 |
Apoptosis; Phosphatase; ATM/ATR; Gamma-secretase | Apoptosis; DNA Damage/DNA Repair; Metabolism; Neuroscience; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Stem Cells |
Ro 90-7501 是一种淀粉样 β42 (Aβ42) 原纤维和 TPR 依赖性 PP5 抑制剂,是一种新型宫颈癌细胞放射增敏剂,可抑制 ATM 磷酸化 ,促进细胞凋亡,诱导细胞周期停滞。Ro 90-7501 具有抗病毒活性和潜在的抗癌活性,抑制 ATM 磷酸化和 DNA 修复,抑制HCMV。 | |||
T23888 |
CID-5056270
|
ROCK | Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells |
CID-5056270具有抗癌活性,对肺癌肛门癌、膀胱癌、宫颈癌、外阴癌、阴茎癌、伯基特淋巴瘤乳腺癌和骨癌具有抑制作用,可用来研究高血压、老年痴呆症度、阿尔茨海默病和动脉硬化。 | |||
T2597 |
Norgestrel
甲基炔诺酮,SH-850,FH 122-A,炔诺孕酮,WY-3707,SH-70850 |
Estrogen/progestogen Receptor; Reactive Oxygen Species | Endocrinology/Hormones; Immunology/Inflammation; Metabolism; NF-κB |
Norgestrel (WY-3707) 是一种孕酮的合成类似物,是一种口服避孕药中常见的化合物,也是一种神经保护性强抗氧化剂,能够防止光诱导的感光细胞中的ROS 的生成以及细胞死亡。 | |||
T77423 |
Lirilumab
ONO-4483,IPH2102 |
Virus Protease | Microbiology/Virology |
Lirilumab (IPH2102) 是一种针对杀伤性免疫球蛋白样受体抗体 KIR2D 的抗体,具有抗肿瘤活性,通过 Vav1 依赖性 NF-κB 去抑制增强自然杀伤细胞的抗 HPV+ 宫颈癌活性,可用于研究白血病、头颈部鳞状细胞癌 (SCCHN)。 | |||
T17228 |
Sabizabulin
ABI-231,VERU-111 |
Microtubule Associated | Cytoskeletal Signaling |
Sabizabulin (ABI-231) 是一种有效且具有口服生物利用度的 α 和 β 微管蛋白抑制剂,可对抗黑色素瘤和前列腺癌细胞系。 Sabizabulin 通过靶向 HPV E6 和 E7 抑制宫颈癌细胞的肿瘤生长和转移表型。 Sabizabulin 显示出抗增殖活性,可用于前列腺癌研究。 | |||
T76863 |
Elezanumab
AE12-1Y-QL,ABT-555 |
TGF-beta/Smad | Stem Cells |
Elezanumab(ABT-555) 是一种有效的人抗 RGMa 单克隆抗体。Elezanumab 通过 SMAD1/5/8 通路发挥对 RGMa 介导的 BMP 信号传导的抑制作用,IC50 约为 97 pM。在神经元损伤和脱髓鞘模型中,Elezanumab 促进神经再生、神经保护和神经恢复。Elezanumab 促进皮质脊髓轴突生长为脊髓灰质,并增强腹角的血清素能神经支配,形成颈部病变尾部的突触连接。 | |||
T34508 |
Sanazole
AK2123,AK-2123,AK 2123 |
||
Sanazole is a 3-nitrotriazole cpd. It can affect the human cervical cancer cell line. | |||
T26601 |
ALRT 1550
LG-1550,LGD-1550,ALRT-1550,LG1550,ALRT-550,ALRT1550 |
||
ALRT 1550, a retinoic acid agent (RAR) agonist, is used potentially for the treatment of cervical carcinoma. | |||
T29202 |
Zalypsis
PM00104,PM 10450,PM-00104,PM 00104,PM10450,PM-10450 |
||
Zalypsis, a transcription factor inhibitor, is used potentially for the treatment of lymphoma, and cervical carcinoma. | |||
T70594 |
Gliotoxin monoacetate
|
||
Gliotoxin monoacetate is a toxin found in Aspergillus. It induces apoptosis in cervical cancer cells and chondrosarcoma cells, suppresses the adaptive immune response in leukocytes, and inhibits the proteasome in Plasmodium falciparum. | |||
T76716 | Cadonilimab | ||
Cadonilimab (AK104) 为一种IgG1支架Fc工程化的人源化抗体,针对PD1/CTLA4。适用于转移性宫颈癌研究。 | |||
T76015 |
HPV16 E7 (86-93) (TFA)
|
||
HPV16 E7 (86-93) TFA,一种HLA-A2.1限制的HPV16 E7衍生肽,在宫颈癌中显示出免疫原性。 | |||
T25912 |
Oxypyrronium bromide
L.D. 3055,Immetropan,LD 3055,LD3055,LD-3055 |
||
Oxypyrronium bromide 一种含有季铵的抗胆碱能和解痉剂。在动物模型中,它抑制胃运动、迷走神经刺激或乙酰胆碱静脉注射引起的低血压;鼓索神经刺激引起的流涎和节前颈交感神经刺激引起收缩。 | |||
T81732 |
Myosin light chain kinase fragment 11-19 amide
MLCK(11-19) amide |
||
Myosinlight chain kinase fragment 11-19 amide (MLCK(11-19) amide) 为MLCK专一性多肽抑制剂,具抑制低渗透压刺激下Ca2+入细胞的能力,并可应用于人类宫颈癌研究。 | |||
T60544 |
HPV18-IN-1
|
||
HPV18-IN-1 (Compound H1) 是有效的HPV18抑制剂,可防止宫颈癌细胞的过早和异常细胞增殖。它可抑制 E7-Rb-E2F 细胞通路和 DNA 甲基化, 具有癌症研究的潜力。 | |||
T76709 | Zimberelimab | ||
Zimberelimab 是一种全人源IgG4抗PD-1单克隆抗体,具有很高的亲和力和选择性。 Zimberelimab 具有抗肿瘤活性,可用于各种癌症研究,包括宫颈癌、非小细胞肺癌和霍奇金淋巴瘤。 | |||
T81400 |
Pritumumab
|
||
Pritumumab是一种自然源的人类IgG1kappa单克隆抗体,其最初源于一位宫颈癌患者的区域淋巴结分离得到。该单抗特异性地识别波形蛋白,该蛋白在多种恶性肿瘤细胞表面展现。Pritumumab在胶质母细胞瘤的科研应用中具有潜在价值。 | |||
T60421 |
Antitumor agent-68
|
||
Antitumor agent-68 是一种有效的微管蛋白抑制剂,具有良好的抗肿瘤活性,对宫颈癌细胞系 HeLa 和乳腺癌细胞系 MCF-7 细胞的IC50值分别为 3.6 和 3.8 μM。Antitumor agent-68 以剂量依赖的方式表现出良好的 ROS 和DPPH 自由基的清除活性。 | |||
T68667 |
Oxanosine
|
||
Oxanosine is an analog of guanosine that has been found in S. capreolus and has diverse biological activities, including antibacterial, antiviral, and anticancer properties. It is active against a variety of bacteria, including S. flexneri, P. mirabilis, and E. coli (MICs = 6.25, 12.5, 25 µg/ml, respectively, on peptone, but not nutrient, agar). Oxanosine inhibits replication of the HIV-1 strain IIIb in infected CEM and U937, but not H9, cells (EC50s = 7, 27, and >500 µg/ml, respectively). It al... | |||
T83741 |
S7 TFA
Leu-Ser-Leu-Iso-Thr-Arg-Leu-OH |
||
S7是一种IL-6受体的肽类拮抗剂,能够浓度依赖性地抑制IL-6与IL-6受体的结合。在C-33 A宫颈癌细胞和RPMI-8226 B细胞淋巴细胞中,S7 (50 µM) 能抑制IL-6诱导的VEGF水平增加。在每两天给药一次,剂量为50 mg/kg的条件下,S7能减少IL-6过表达的C-33 A宫颈癌小鼠异种移植模型中的肿瘤体积。当S7与半胱氨酸结合,并连接到包裹多柔比星的脂质纳米粒子(LNPs)表面时,能增强LNPs对胶质瘤的靶向性,并在U251胶质母细胞瘤小鼠异种移植模型中提高生存率。 | |||
T26366L |
Prasterone sulfate sodium hydrate
Sodium dehydroepiandrosterone sulfate,Prasterone sulfate sodium salt dihydrate,5-Androsten-3β-ol-17-one sulfate sodium salt dihydrate |
||
Prasterone is an endogenous steroid hormone. Prasterone acts as an agonist at ERβ, NMDA, and σ1 receptors, a partial agonist at ERα and AR, and antagonist at GABA-A receptors. It displays a variety of biologocial activities, including enhancing working me | |||
T37435 | PACAP-related Peptide (rat) (trifluoroacetate salt) | PACAP | GPCR/G Protein |
PACAP-related peptide (PRP) is an endogenous 29-amino acid peptide that belongs to the secretin/glucagon superfamily of peptides, which includes secretin , glucagon , glucagon-like peptide-1 , GLP-2 , and pituitary adenylate cyclase-activating polypeptide . It is expressed in rat hypothalamus as well as within the nerves of the median eminence, the anterior pituitary, bed nucleus of the stria terminalis, cerebellum, cerebral cortex, and amygdala. PRP is also expressed in vaginal, uterine cervica... | |||
TP1554 |
HPV16 E7 (86-93)
|
||
This is amino acids 86 to 93 fragment of the human papilloma virus (HPV) type 16 oncoprotein E7. This HPV16-encoded peptide has very high affinity of binding to the HLA-A*0201 molecule.This immunogenic fragment may be used in vaccines for the prevention a | |||
T76997 | Socazolimab | ||
Socazolimab (ZKAB001) 是一种针对PD-L1的单克隆抗体,在治疗复发或转移性宫颈癌方面展现了持久的安全性和有效性。此外,Socazolimab 也被认为在小细胞肺癌、食管鳞状细胞癌 (ESCC)、晚期尿路上皮癌及骨肉瘤治疗中具有潜在应用价值。 | |||
T36195 |
CAY10744
|
||
CAY10744 is a topoisomerase II-α poison.1 It inhibits topoisomerase II-α by 78.9% when used at a concentration of 20 μM. CAY10744 is selective for topoisomerase II-α over topoisomerase I providing 100 and 0% inhibition, respectively, at 100 μM. It inhibits proliferation of HCT15 colon, T47D breast, DU145 prostate, and HeLa cervical cancer cells (IC50s = 0.014, 0.00267, 0.072, and 2.46 μM, respectively). CAY10744 induces apoptosis in T47D cells when used at concentrations of 10 and 30 μM. CAY1074... | |||
T60933 |
B-Raf IN 7
|
||
B-Raf IN 7 (compound 6a) 是 B-Raf 的有效抑制剂,IC50值为 110.23 nM。B-Raf IN 7 对结肠癌细胞(HCT-116)、乳腺癌细胞 (MCF-7)、肝癌细胞 (HEPG-2)、人宫颈癌细胞 (Hela) 和人前列腺癌细胞 (PC-3) 具有抗肿瘤活性。其 IC50值分别为 7.50、9.87、10.57、11.63 和 12.83 μM。 | |||
T36404 |
PRLX-93936
|
||
PRLX-93936 is an analog of erastin that has antitumor activity. It inhibits the hypoxia-inducible factor 1 (HIF-1) signaling pathway under hypoxic conditions (IC50 = 0.09 μM in a cell-based reporter assay). PRLX-93936 (1 μM) also inhibits hypoxia-induced increases in HIF-1α expression in ME-180 cervical cancer cells. It inhibits the growth of HT-1080 fibrosarcoma, OVCAR-5 ovarian cancer, BJELR tumorigenic primary fibroblast, and PANC-1 pancreatic cancer cells with IC50 values of less than 100 nM... | |||
T71279 |
BPR1K653
|
||
BPR1K653 is a potent Aurora kinase inhibitor with potential anticancder activity. BPR1K653 specifically inhibited the activity of Aurora-A and Aurora-B kinase at low nano-molar concentrations in vitro. BPR1K653 was potent in targeting a variety of cancer cell lines regardless of the tissue origin, p53 status, or expression of MDR1. At the cellular level, BPR1K653 induced endo-replication and subsequent apoptosis in both MDR1-negative and MDR1-positive cancer cells. Importantly, it showed potent ... | |||
T68249 |
IRC-083927 HCl
|
||
IRC-083927 HCl is novel and potent microtubule inhibitor with potential anticancer activity. IRC-083927 inhibits the tubulin polymerization by a binding to the colchicine site. IRC-083927 inhibits in vitro cell growth of human cancer cell lines in the low nanomolar range. More interesting, it remains highly active against cell lines resistant to microtubule-interacting agents (taxanes, Vinca alkaloids, or epothilones). Chronic oral treatment with IRC-083927 (5 mg/kg) inhibits the growth of two h... | |||
T35687 |
Collismycin A
|
||
Collismycin A is a bacterial metabolite originally isolated from Streptomyces that has diverse biological activities, including antibacterial, antiproliferative, and neuroprotective properties. It is active against a variety of bacteria (MICs = 6.25 and 100 μg/ml) and fungi (MICs = 12.5-100 μg/ml). It inhibits proliferation of A549 lung, HCT116 colon, and HeLa cervical cancer cells (IC50s = 0.3, 0.6, and 0.3 μM, respectively) and NIH373 fibroblasts (IC50 = 56.6 μM) but not MDA-MD-231 breast canc... | |||
T83854 |
BRC4wt TFA
|
||
BRC4wt是一种从人类BRCA2的BRC4重复区(1521-1536)衍生而来的乙酰化肽,并且是BRCA2与RAD51之间的蛋白质-蛋白质相互作用的抑制剂。当与阳离子穿膜肽(Arg)9结合时,BRC4wt缩短了体外DNA复制轨迹长度,并降低了由DNA拓扑异构酶I抑制剂坎普特西汀引起的DNA损伤的同源修复频率,同时也增强了聚(ADP-核糖)聚合酶(PARP)抑制剂奥拉帕尼在HeLa人类宫颈癌细胞和U2OS人类骨肉瘤细胞中诱导的细胞死亡,但在非癌症细胞hTERT RPE-1、MRC-5或MCF-10A中则不然。 | |||
T83910 |
S1PL-IN-31
Sphingosine-1-Phosphate Lyase Inhibitor 31,S1PL Inhibitor 31,S1P Lyase Inhibitor 31 |
||
S1PL-IN-31是一种鞘氨醇-1-磷酸(S1P)裂解酶的抑制剂(IC50 = 210 nM),同时也是Smoothened(Smo)受体的对抗剂(IC50 = 440 nM)。在体内,S1PL-IN-31 (每天2 mg/kg)能够防止实验性自身免疫性脑炎(EAE)模型大鼠中,由髓鞘少突胶质细胞糖蛋白(MOG)肽段MOG29-152诱发的颈部及胸部淋巴细胞渗透和神经肌肉虚弱。该化合物降低了大鼠的淋巴细胞总数及CD4+ T细胞、CD8+ T细胞和B细胞的水平。S1PL-IN-31 (每天3及10 mg/kg剂量)在雄性和雌性大鼠心脏和淋巴结中增加了S1P水平,并且在雌性大鼠中降低了心率。 | |||
T36346 |
Ac-VEID-AMC (ammonium acetate salt)
|
||
Ac-VEID-AMC is a fluorogenic substrate based on the caspase-6 cleavage site in lamin A at amino acids VEID during apoptosis.1It has also been reported to be cleaved by related proteases, including caspase-8.2Caspase activity can be quantified by fluorescent detection of free AMC (also known as 7-amino-4-methylcoumarin), which is excited at 340-360 nm and emits at 440-460 nm. 1.Talanian, R.V., Quinlan, C., Trautz, S., et al.Substrate specificities of caspase family proteasesJ. Biol. Chem.272(15)9... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T11363 |
Ganoderic acid F
|
Others | Others |
Ganoderic acid F 是一种灵芝酸。它具有抗肿瘤和抗转移的活性,与抑制血管生成和涉及细胞增殖和细胞死亡,致癌作用,氧化应激,钙信号传导和内质网应激的蛋白质改变等机制相关。 | |||
T5S1133 |
Ganoderic acid D
灵芝酸D,灵芝酸 D |
Apoptosis; Sirtuin | Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair |
Ganoderic acid D 是高度氧化的四环三萜,是灵芝的主要活性成分,可诱导 HeLa 人宫颈癌细胞凋亡。它上调 SIRT3的蛋白质表达并通过 SIRT3 诱导脱乙酰化的亲环蛋白 D 。它抑制结肠癌细胞的能量重编程,包括结肠癌细胞中的葡萄糖摄取,乳酸、丙酮酸和乙酰辅酶的产生。 | |||
T13475 |
β-Aminopropionitrile
3-氨基丙腈,3-Aminopropionitrile,BAPN |
Others; Endogenous Metabolite | Metabolism; Others |
β-Aminopropionitrile (3-Aminopropionitrile) 是赖氨酰氧化酶的特异性抑制剂。 | |||
T14046 |
Anandamide
花生四烯酸乙醇胺,(5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide |
Cannabinoid Receptor; Endogenous Metabolite | GPCR/G Protein; Metabolism |
Anandamide ((5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide) 是一种免疫调节剂,通过大麻素受体 CB1 和 CB2 起作用,还通过中枢神经系统中的其他靶点起作用,如 GPR18/GPR55。 | |||
TN6730 |
Epoxyazadiradione
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NF-κB | NF-κB |
Epoxyazadiradione 是从印楝果实中得到的柠檬苦素。它能够可逆的、非竞争性的抑制人类、约氏疟原虫、疟原虫的互变异构酶活性。它具有抗疟原虫和人类 MIF 诱导的促炎反应的潜力。 | |||
T4036 |
Solasodine
Solancarpidine,Purapuridine,澳洲茄铵,Solasodin |
Apoptosis; Others; E1/E2/E3 Enzyme; Antifungal | Apoptosis; Microbiology/Virology; Others; Ubiquitination |
Solasodine (Purapuridine) 是存在于茄科植物中的一种类固醇生物碱。它具有神经保护、降压、抗真菌、抗癌、抗动脉粥样硬化、抗雄激素和抗炎活性。 | |||
T8787 |
Drotaverine hydrochloride
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PDE | Metabolism |
Drotaverine hydrochloride 是磷酸二酯酶 4 (PDE4)的抑制剂,也是 L 型电压依赖钙通道(L-VDCC)的阻滞剂,可阻断3',5'-环腺苷单磷酸的降解。它在体内有抗痉挛效果,但无抗胆碱能的效果。 | |||
TN1393 |
(-)-Anonaine
番荔枝碱 |
Apoptosis; Antioxidant; Parasite; Antifungal | Apoptosis; Microbiology/Virology; oxidation-reduction |
(-)-Anonaine 可从木兰科和安妮科的几个物种中提取出来,具有抗疟、抗菌、抗真菌、抗氧化、抗癌、抗抑郁和血管舒张的活性。(-)-Anonaine 通过 Bax 和 caspase 依赖性途径诱导人类宫颈癌(HeLa)细胞的凋亡,诱导 DNA 损伤并抑制人类肺癌 h1299细胞的生长和迁移。 | |||
T0122 |
Bergenin
Cuscutin,Bengenin,岩白菜素 |
Apoptosis; IL Receptor; Virus Protease; TNF; NF-κB; Antibacterial; NOD; Autophagy; Antifungal | Apoptosis; Autophagy; Immunology/Inflammation; Microbiology/Virology; NF-κB |
Bergenin (Bengenin) 是一种在许多药用植物中发现的多酚,有细胞保护和抗氧化作用。它还具有广泛的保肝、抗炎、抗肿瘤、抗病毒、抗真菌以及免疫调节作用。 | |||
TN6010 |
Picrasidine S
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Picrasidine S shows the potent cytotoxicity against human HeLa cervical, gastric MKN-28, and mouse melanoma B-16 cancer cells, it also shows the potent antibacterial activity against two strains of pathogenic bacteria methicillin-resistant Staphylococcus | |||
TN4109 |
Ganolucidic acid A
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HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Ganolucidic acid A exhibits cytotoxicity, has inhibitory activities against human HeLa cervical cancer cell lines. It shows significant anti-human immunodeficiency virus (anti-HIV)-1 protease activity with IC50 values of 20-90 microM. | |||
TN4102 | Ganoderic acid AM1 | Others | Others |
Ganoderic acid AM1 treatment for 48 h inhibited the proliferation of HeLa human cervical carcinoma cells with IC(50) values of 19.8+/-0.7 microM. | |||
T69368 |
GKK1032B
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GKK1032B is a fungal metabolite that has antiproliferative and antibacterial activities. GKK1032B inhibits the growth of HeLa S3 cervical and MCF-7 breast cancer cells and Vero cells. It also inhibits the growth of B. subtilis and M. tuberculosis. | |||
T3425 |
Polyphyllin G
重楼皂苷VII,Polyphyllin VII,Polyphyllin VII,Y-0166,重楼皂苷G |
Others | Others |
Polyphyllin G (Polyphyllin VII) 是从Paris yunnanensis 的根茎中分离出来的,具有抗菌活性,抑制革兰氏阳性和革兰氏阴性细菌的生长。它是polyphyllin 家族的主要成员,对肺癌、乳腺癌、结直肠癌、宫颈癌、肝细胞癌和骨肉瘤等多种癌症具有很强的抗癌活性。 | |||
T80019 |
17-Hydroxyneomatrine
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17-Hydroxyneomatrine 是一种从苦参 (Sophora flavescens) 提取的化合物,有效抑制人宫颈癌Hela细胞生长,并展现抗菌、抗过敏、抗肿瘤、抗心律失常、消肿、利尿、免疫调节等多种生物活性。 | |||
TN2328 |
Zeylenone
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Apoptosis; ERK; MAPK; Akt; PI3K; mTOR | Apoptosis; Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling |
Zeylenone 是一种来自 Uvaria grandiflora的环己烯氧化物,具有抗肿瘤和抗癌细胞增殖活性,通过 PI3K/AKT/mTOR 和 MAPK/ERK 信号通路抑制宫颈癌细胞增殖,诱导细胞凋亡 (apoptosis)。 | |||
T35609 |
19-O-Acetylchaetoglobosin A
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19-O-Acetylchaetoglobosin A is a fungal metabolite originally isolated fromC. globosumthat has actin polymerization inhibitory and cytotoxic activities.1,2It inhibits actin polymerization in a cell-free assay when used at a concentration of 2 μM.219-O-Acetylchaetoglobosin A (3.2, 10, and 32 μg/ml) is cytotoxic to HeLa cervical cancer cells.1 1.Umeda, M., Ohtsubo, K., Saito, M., et al.Cytotoxicity of new cytochalasans from Chaetomium globosumExperientia31(4)435-438(1975) 2.Sekita, S., Yoshihira, ... | |||
TN4194 |
Heliangin
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IL Receptor; TNF; NF-κB; MAPK; Prostaglandin Receptor | Apoptosis; GPCR/G Protein; Immunology/Inflammation; MAPK; NF-κB |
Heliangin shows anti-inflammatory effects, it can inhibit lipopolysaccharide-induced inflammation through signaling NF-κB pathway on LPS-induced RAW 264.7 cells. Heliangin has anti-cancer activity, it exhibits cytotoxicity against human oral epidermoid ( | |||
TMA1008 |
Ganoderic acid S
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Others | Others |
A novel combination of triterpenoids includes at least ganoderic acid S (GAS), ganoderic acid T (GAT), ganoderic acid Me (GAMe), ganoderic acid R (GAR), and ganodermic acid S (GMAS), the composition is suitable for the treatment or prophylaxis of colon ca | |||
T75629 | Ganoderic acid Mk | ||
Ganoderic acid Mk (GA-Mk)为来源于灵芝菌丝的三萜酸类化合物,能有效抑制细胞增殖,并通过线粒体途径诱导HeLa细胞的细胞凋亡(apoptosis),在宫颈癌研究中具有应用价值。 | |||
TN3968 | Epifriedelanol acetate | Others | Others |
Epifriedelanol exhibits antibacterial activities. It also can reduce cellular senescence in human primary cells and may be used to develop dietary supplements or cosmetics that modulate tissue aging or aging-associated diseases. Epifriedelanol and friedel | |||
T79941 |
Antimycin A2c
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Apoptosis | Apoptosis |
Anticanceragent 141(compound AE)是一种针对HPV感染宫颈癌具有抑制作用的抗霉素生物碱。该化合物能够抑制宫颈癌HeLa细胞的增殖并导致细胞周期在S期停滞。Anticanceragent 141破坏线粒体功能,诱导caspase依赖性细胞凋亡,并激活ROS介导的泛素依赖性蛋白酶体系统,进而引起E6/E7癌蛋白的降解。 | |||
T36448 |
(E)-Ajoene
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(E)-Ajoene is a disulfide that has been found inA. sativumand has diverse biological activities.1,2,3,4It is active against Gram-positive and Gram-negative bacteria (MICs = 10-250 and 150->500 μg/ml, respectively) and fungi (MICs = 15-50 μg/ml).1(E)-Ajoene inhibits proliferation of a variety of cancer cells, including MDA-MB-231 breast, HeLa cervical, and WHCO1 esophageal cancer cells (IC50s = 18.6, 61, and 39.2 μM, respectively).2It also inhibits human glutathione reductase andT. cruzitrypanoth... | |||
T36000 |
3-Hydroxyterphenyllin
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3-Hydroxyterphenyllin is a p-terphenyl fungal metabolite originally isolated from A. candidus that has diverse biological activities, including antioxidant, antiproliferative, antibacterial, and antiviral properties.1,2,3,4 It has a 96% scavenging effect on 2,2-diphenyl-1-picrylhydrazyl radicals when used at a concentration of 100 μg/ml.2 3-Hydroxyterphenyllin inhibits the growth of HeLa cervical, A549 lung, and HepG2 liver cancer cells (IC50s = 23, 36, and 32 μM, respectively), as well as methi... |