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611

抑制剂 & 化合物

21

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T11063	DMT1 blocker 1	Others	Others
	DMT1 blocker 1 是二价金属转运蛋白1 (DMT1) 的阻断剂，IC50 为 0.64 μM，可以阻断体内肠细胞的铁摄取。
T12504	(+)-KCC2 blocker 1	Potassium Channel	Membrane transporter/Ion channel
	(+)-KCC2 blocker 1 是 KCC2 的选择性阻断剂 (IC50 = 0.4 μM)。
T11064	DMT1 blocker 2	Others	Others
	DMT1 blocker 2 是一种二价金属转运蛋白 1 的直接抑制剂(IC50:0.83 μM)。它可以阻断体内肠细胞的铁摄取。
T10690	Cav 2.2 blocker 1	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Cav 2.2 blocker 1 是一种N 型钙离子通道 (Cav 2.2) 的阻断剂，IC50值为 1 nM，可用于治疗疼痛。
T39717	VGSC blocker-1
	VGSC blocker-1 is a powerful small molecule that serves as a blocker for the neonatal isoform of the VGSC subtype known as Nav1.5 (nNav1.5). It effectively blocks INa peak currents by 34.9% at a concentration of 1 μM, and demonstrates a 0.3% inhibition of cell invasion at the same concentration in the MDA-MB-231 human breast cancer cell line, without compromising cell viability.
T28132	NaV1.7 Blocker-801
	NaV1.7 Blocker-801 is a potent NaV1.7 blocker.
T72170	NaV1.2/1.6 channel blocker-1	Sodium Channel	Membrane transporter/Ion channel
	NaV1.2/1.6 channel blocker-1 是一种有效的 NaV1.2/1.6 channel 阻滞剂，对 rNaV1.6 和 hNaV1.2 有抑制作用。NaV1.2/1.6 channel blocker-1 可用于研究全身性癫痫和运动障碍。
T69387	NMO-IgG blocker A-01
	NMO-IgG blocker A-01 is a idiotype-specific blocker of neuromyelitis opticaimmunoglobulin g (nmo-igg) binding to aquaporin-4 (aqp4)
T11927	M2 ion channel blocker	Others	Others
	M2 ion channel blocker ,Antiviral agent, is capable of inhibiting and blocking the activity of M2 ion channel.
T12153	N-type calcium channel blocker-1	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	N-type calcium channel blocker-1 is an orally active analgesic agent,shows high affinity to functionally block N-type calcium channels.
T62586	Cav 2.2/3.2 blocker 1
	Cav 2.2/3.2 blocker 1 (Compound 9e) 是一种神经钙离子通道 (neuronal calcium channel) 阻断剂，能够作用于 Cav2.2 (IC50: 1.22 μM) 和 Cav3.2 (IC50: 80 μM)。Cav 2.2/3.2 blocker 1 可以穿透中枢神经系统。
T26817	Bim-BLK-A Bim Blocker A,Compound A,Bim BLK A,BimBLKA
	Bim-BLK-A efficiently blocks Bim-induced apoptosis after Bax is activated on the mitochondria. The cellular target of Bim-BLK-A was identified to be the succinate dehydrogenase subunit B (SDHB) protein of complex II of the mitochondrial electron transfer
T80930	TRPV2-selective blocker 1
	TRPV2-selective blocker 1 (compound IV2-1) 为选择性TRPV2通道阻断剂，具有6.3 μM IC50，不对TRPV1、TRPV3和TRPV4通道产生影响。该化合物能够抑制巨噬细胞中TRPV2介导的Ca2+流入，进而抑制其吞噬功能。
T83705	BING TFA Blocker of Inter-membrane Stress Responses of Gram-negative Bacteria
	BING是一种来源于日本稻田鱼(O. laptipes)的抗菌肽，由液泡蛋白质分选相关蛋白13D样(Vps13D)衍生而来。对包括耐甲氧西林的金黄色葡萄球菌(MRSA; MICs = 4-64 µg/ml)在内的各种革兰氏阴性和革兰氏阳性细菌都有活性。与氨苄西林、阿莫西林和新霉素共同使用时，对抗铜绿假单胞菌(P. aeruginosa)表现出协同效应，并能抑制大肠杆菌(E. coli)对卡那霉素和氨苄西林的抗药性发展。在体内，BING提高了被鳗弧菌(E. tarda)感染的O. laptipes的生存率。
T15385	Glibornuride	Potassium Channel	Membrane transporter/Ion channel
	Glibornuride 是对 ATP 敏感的 K+通道 (KATP 通道) 阻滞剂，pKi 为 5.75。Glibornuride 显示抗糖尿病活性。
T0440	Oxcarbazepine GP 47680,奥卡西平	Apoptosis; Sodium Channel	Apoptosis; Membrane transporter/Ion channel
	Oxcarbazepine (GP 47680) 是一种钠通道阻滞剂，有效抑制胶质母细胞瘤细胞生长并诱导胶质母细胞瘤细胞凋亡或 G2/M 停滞，具有抗癌和抗惊厥作用。
T21454	Nicardipine Cardene,Dagan,尼卡地平,Antagonil,Flusemide	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Nicardipine (Cardene) 是一种二氢吡啶类钙通道阻滞剂，可阻断心脏钙通道，IC50为 1 μM，可用于治疗心绞痛和高血压。
T7806	Licarbazepine 10,11-hydroxy-10,11 Dihydrocarbamezer,10,11-二氢-10-羟基卡马西平	Others	Others
	Licarbazepine (10,11-hydroxy-10,11 Dihydrocarbamezer) 是一种有效的电压门控钠通道阻滞剂，具有抗惊厥和稳定情绪的功效。
T3574	Sematilide hydrochloride 司美利特,CK-1752A,CK-1752,Sematilide HCl	Potassium Channel	Membrane transporter/Ion channel
	Sematilide hydrochloride (CK-1752) 是一种选择性的 IKr 通道阻滞剂。Sematilide 以浓度依赖性抑制延迟整流钾通道 (K+current)，IC50为 25 μM。Sematilide 是一种 III 类抗心律不齐剂。
T8388	Vonoprazan TAK-438 (free base),沃诺拉赞	Proton pump	Membrane transporter/Ion channel
	Vonoprazan (TAK-438 (free base)) 是一种质子泵抑制剂，是口服活性钾竞争性酸阻断剂，有抗分泌作用。在 pH 为 6.5 时，它抑制猪胃微粒体中的 H+,K+-ATPase 酶活性，IC50值为 19 nM。它可用于研究胃酸相关疾病。
T0866	Propafenone Rythmol,普罗帕酮,Propafenonum	Potassium Channel; MRP; Sodium Channel	Immunology/Inflammation; Membrane transporter/Ion channel
	Propafenone (Propafenonum) 是钠通道阻滞剂，它对 β 受体具有高亲和力 (IC50=32 nM)。它能够阻断瞬时外向钾电流 (Ito) (IC50: 4.9 nM) 和持续延迟整流器K+电流 (Isus) (IC50: 8.6 nM) ，具有抗心律失常的作用。它能够诱导线粒体功能障碍及诱导细胞凋亡，从而抑制食管癌增殖。
T21254	Vonoprazan Fumarate TAK-438,TAK 438,Vonoprazan Fumurate,TAK438,富马酸沃诺拉赞	Proton pump	Membrane transporter/Ion channel
	Vonoprazan Fumarate (TAK438) 是质子泵的有效抑制剂，是口服有效的高效钾竞争性酸阻断剂，具有抗分泌活性。在 pH 为 6.5 时，它抑制猪胃微粒体中的 H+,K+-ATPase 酶活性，IC50为 19 nM。它被开发用于研究酸相关疾病，如消化性溃疡和胃食管反流病。
T0342	Carvedilol phosphate hemihydrate Carvedilol phosphate,BM 14190 (phosphate hemihydrate),卡维地洛磷酸盐	VEGFR; Others; Potassium Channel; LDL; Integrin; Gap Junction Protein; NADPH; Adrenergic Receptor; Autophagy	Angiogenesis; Autophagy; Cytoskeletal Signaling; GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Neuroscience; Others; Tyrosine Kinase/Adaptors
	Carvedilol phosphate hemihydrate (BM 14190 phosphate hemihydrate) 是一种外消旋混合物，是一种非选择性β/α-1受体阻断剂，具有抗高血压活性且缺乏内在拟交感神经活性。
T1615	Irbesartan 厄贝沙坦,SR-47436,BMS-186295	Apoptosis; RAAS	Apoptosis; Endocrinology/Hormones
	Irbesartan (SR-47436) 是一种 1 型血管紧张素 II 受体拮抗剂，IC50为1.3 nM。
T1215	Nicardipine hydrochloride 盐酸尼卡地平,RS-69216,Nicardipine HCl,YC-93 Hydrochloride	Calcium Channel; Adrenergic Receptor; AChR; Autophagy	Autophagy; GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Neuroscience
	Nicardipine hydrochloride (YC-93 Hydrochloride) 是一种钙通道阻滞剂，IC50为 1 μM。它可阻断某些细胞壁中的钙离子并抑制冠状动脉和外周动脉的收缩，从而降低对氧气的需求心肌和减少动脉收缩和痉挛。它在临床上用作脑和冠状血管扩张剂。
T3280	Clodronate disodium tetrahydrate clodronic acid disodium tetrahydrate,Disodium clodronate tetrahydrate,Clastoban,氯屈膦酸二钠(四水合物),Clodronate disodium	IL Receptor; TNF	Apoptosis; Immunology/Inflammation
	Clodronate disodium tetrahydrate (Clastoban) 是一种选择性、高效的，可逆、Cl-竞争性的囊泡核苷酸转运体阻滞剂(IC50:15.6 nM)。是一种双膦酸盐，具有抗骨质疏松、抗炎作用，可用于缓解疼痛的研究。它可抑制神经元释放囊泡 ATP，缓解慢性神经病理性疼痛和炎症性疼痛。
T6666	Sevelamer Carbonate	Others	Others
	Sevelamer carbonate 是一种口服具有活力的非钙基磷酸盐结合剂，能有效降低体内血清磷水平，但对体内血清钙、氯水平影响极小，可用于研究慢性肾脏病的高磷血症。它被认为是七氟乙烯的一种改进的缓冲形式。
T22330	Fenamic acid N-苯基邻氨基苯甲酸,2-Anilinobenzoic acid,Diphenylamine-2-carboxylic acid,2-(Phenylamino)benzoic acid,N-Phenylanthranilic acid	Chloride channel	Membrane transporter/Ion channel
	Fenamic acid (N-Phenylanthranilic acid) 是氯通道阻滞剂。
T23301	(S)-(+)-Niguldipine hydrochloride	Others	Others
	L-type Ca2+ channel blocker and α1A-adrenoceptor antagonist
T26689	AVE-0118 AVE 0118,AVE0118	Potassium Channel	Membrane transporter/Ion channel
	AVE-0118 是一种钾通道阻滞剂，可抑制持续性心房颤动。
T29050	UK 66914 UK66914,UK-66914	Potassium Channel	Membrane transporter/Ion channel
	UK 66914 是一种 K（+）通道阻断剂，可用于研究心律失常。
T11979	McN5691 RWJ26240	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	McN5691 is a voltage sensitive calcium channel blocker.
T10813	Cilobradine hydrochloride DK-AH 269	HCN Channel	Membrane transporter/Ion channel
	Cilobradine hydrochloride (DK-AH 269) 是一种 HCN 通道阻断剂。
T60010	BTT-266	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	BTT-266 是一种电压门控钙通道阻滞剂，用于疼痛管理。
T79835	Aneratrigine hydrochloride	Sodium Channel	Membrane transporter/Ion channel
	Aneratrigine hydrochloride 是一种钠通道蛋白9型亚基阻断剂，可用于预防或治疗钠通道阻断剂相关疾病。
T22745	DPO-1	Potassium Channel	Membrane transporter/Ion channel
	DPO-1 可以高效抑制电压门控钾离子通道Kv1.5，也可以阻断超快速延迟整流钾电流。它能够预防房性心律失常。
T3557	GAL-021 GAL 021	Potassium Channel	Membrane transporter/Ion channel
	GAL-021新型静脉内BKCa-channel 阻滞剂。
T7638	NPPB	Chloride channel	Membrane transporter/Ion channel
	NPPB 是外向整流氯化物通道阻断剂，IC50 为 80 nM。
T20341	DNDS	CFTR	Membrane transporter/Ion channel
	DNDS 是电压依赖性囊性纤维化跨膜电导调节剂 (CFTR) 的通道阻滞剂。
T31614	Elpetrigine GW-273293,JZP 4,JZP4,GW273293,JZP-4,GW 273293
	Elpetrigine( GW 273293, JZP-4) is effective calcium and sodium channel blocker and is currently being evaluated in patients as an anticonvulsant and mood stabilizer.
T3703	ABT-639 ABT 639	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	ABT-639 是一种有效的选择性 T 型钙通道阻滞剂。
T0327	Fendiline hydrochloride Fendiline HCl,盐酸芬他林	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Fendiline hydrochloride (Fendiline HCl) 是一种非选择性钙通道抑制剂。
T15143	DMP-543 XR-543	Others; Potassium Channel	Membrane transporter/Ion channel; Others
	DMP-543 (XR-543) 是一种钾离子通道 (KV7 channel) 阻滞剂。DMP-543可以增强神经递质的释放。
T22675	Co 102862 V 102862	Others; Sodium Channel	Membrane transporter/Ion channel; Others
	Co 102862 是一种电压门控钠通道阻滞剂。 Co 102862 可用于抗惊厥的研究。
T5640	GSK2193874	TRP/TRPV Channel	Membrane transporter/Ion channel
	GSK2193874 是口服有效的TRPV4选择性拮抗剂，作用于rTRPV4和hTRPV4的IC50分别为 2 nM 和 40 nM。
T0121	Azelnidipine CS 905,阿折地平,UR-12592	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Azelnidipine (UR-12592) 是二氢吡啶衍生物，是 L 型钙离子通道阻断剂，有抗高血压作用。
T6577	Manidipine Iperten,Franidipine,Artedil,马尼地平	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Manidipine (Iperten) 是一种二氢吡啶类钙通道阻滞剂，有降压作用。
T12385	PD0176078 PD176078	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	PD0176078 () 是一种新型的 N 型钙通道 (Calcium channel) 阻滞剂。
T31716	Etidocaine Hydrochloride W-19053,Duranest,W19053,W 19053	Sodium Channel	Membrane transporter/Ion channel
	Etidocaine Hydrochloride (W19053) 是一种长效麻醉剂和电压门控钠通道阻滞剂。
T23471	TRAM 39 2-Chloro-alpha,alpha-diphenylbenzeneacetonitrile,TRAM-39,ZINC27105797,2-(2-chlorophenyl)-2,2-diphenylacetonitrile	Potassium Channel	Membrane transporter/Ion channel
	TRAM 39 (2-Chloro-α,α-diphenylbenzeneacetonitrile)是一种选择性的中间传导性钙离子激活的K+通道的阻断剂。

化合物

DMT1 blocker 1

Cat.No: T11063

Target: Others

(+)-KCC2 blocker 1

Cat.No: T12504

Target: Potassium Channel

DMT1 blocker 2

Cat.No: T11064

Target: Others

Cav 2.2 blocker 1

Cat.No: T10690

Target: Calcium Channel

VGSC blocker-1

Cat.No: T39717

NaV1.7 Blocker-801

Cat.No: T28132

NaV1.2/1.6 channel blocker-1

Cat.No: T72170

Target: Sodium Channel

NMO-IgG blocker A-01

Cat.No: T69387

M2 ion channel blocker

Cat.No: T11927

Target: Others

N-type calcium channel blocker-1

Cat.No: T12153

Target: Calcium Channel

Cav 2.2/3.2 blocker 1

Cat.No: T62586

Cat.No: T26817

Synonym: Bim Blocker A,Compound A,Bim BLK A,BimBLKA

TRPV2-selective blocker 1

Cat.No: T80930

Cat.No: T83705

Synonym: Blocker of Inter-membrane Stress Responses of Gram-negative Bacteria

Cat.No: T15385

Target: Potassium Channel

Cat.No: T0440

Synonym: GP 47680,奥卡西平

Target: Apoptosis, Sodium Channel

Cat.No: T21454

Synonym: Cardene,Dagan,尼卡地平,Antagonil,Flusemide

Target: Calcium Channel

Cat.No: T7806

Synonym: 10,11-hydroxy-10,11 Dihydrocarbamezer,10,11-二氢-10-羟基卡马西平

Target: Others

Sematilide hydrochloride

Cat.No: T3574

Synonym: 司美利特,CK-1752A,CK-1752,Sematilide HCl

Target: Potassium Channel

Cat.No: T8388

Synonym: TAK-438 (free base),沃诺拉赞

Target: Proton pump

Cat.No: T0866

Synonym: Rythmol,普罗帕酮,Propafenonum

Target: Potassium Channel, MRP, Sodium Channel

Vonoprazan Fumarate

Cat.No: T21254

Synonym: TAK-438,TAK 438,Vonoprazan Fumurate,TAK438,富马酸沃诺拉赞

Target: Proton pump

Carvedilol phosphate hemihydrate

Cat.No: T0342

Synonym: Carvedilol phosphate,BM 14190 (phosphate hemihydrate),卡维地洛磷酸盐

Target: VEGFR, Others, Potassium Channel, LDL, Integrin, Gap Junction Protein, NADPH, Adrenergic Receptor, Autophagy

Cat.No: T1615

Synonym: 厄贝沙坦,SR-47436,BMS-186295

Target: Apoptosis, RAAS

Nicardipine hydrochloride

Cat.No: T1215

Synonym: 盐酸尼卡地平,RS-69216,Nicardipine HCl,YC-93 Hydrochloride

Target: Calcium Channel, Adrenergic Receptor, AChR, Autophagy

Clodronate disodium tetrahydrate

Cat.No: T3280

Synonym: clodronic acid disodium tetrahydrate,Disodium clodronate tetrahydrate,Clastoban,氯屈膦酸二钠(四水合物),Clodronate disodium

Target: IL Receptor, TNF

Sevelamer Carbonate

Cat.No: T6666

Target: Others

Cat.No: T22330

Synonym: N-苯基邻氨基苯甲酸,2-Anilinobenzoic acid,Diphenylamine-2-carboxylic acid,2-(Phenylamino)benzoic acid,N-Phenylanthranilic acid

Target: Chloride channel

(S)-(+)-Niguldipine hydrochloride

Cat.No: T23301

Target: Others

Cat.No: T26689

Synonym: AVE 0118,AVE0118

Target: Potassium Channel

Cat.No: T29050

Synonym: UK66914,UK-66914

Target: Potassium Channel

Cat.No: T11979

Synonym: RWJ26240

Target: Calcium Channel

Cilobradine hydrochloride

Cat.No: T10813

Synonym: DK-AH 269

Target: HCN Channel

Cat.No: T60010

Target: Calcium Channel

Aneratrigine hydrochloride

Cat.No: T79835

Target: Sodium Channel

Cat.No: T22745

Target: Potassium Channel

Cat.No: T3557

Synonym: GAL 021

Target: Potassium Channel

Cat.No: T7638

Target: Chloride channel

Cat.No: T20341

Target: CFTR

Cat.No: T31614

Synonym: GW-273293,JZP 4,JZP4,GW273293,JZP-4,GW 273293

Cat.No: T3703

Synonym: ABT 639

Target: Calcium Channel

Fendiline hydrochloride

Cat.No: T0327

Synonym: Fendiline HCl,盐酸芬他林

Target: Calcium Channel

Cat.No: T15143

Synonym: XR-543

Target: Others, Potassium Channel

Cat.No: T22675

Synonym: V 102862

Target: Others, Sodium Channel

Cat.No: T5640

Target: TRP/TRPV Channel

Cat.No: T0121

Synonym: CS 905,阿折地平,UR-12592

Target: Calcium Channel

Cat.No: T6577

Synonym: Iperten,Franidipine,Artedil,马尼地平

Target: Calcium Channel

Cat.No: T12385

Synonym: PD176078

Target: Calcium Channel

Etidocaine Hydrochloride

Cat.No: T31716

Synonym: W-19053,Duranest,W19053,W 19053

Target: Sodium Channel

Cat.No: T23471

Synonym: 2-Chloro-alpha,alpha-diphenylbenzeneacetonitrile,TRAM-39,ZINC27105797,2-(2-chlorophenyl)-2,2-diphenylacetonitrile

Target: Potassium Channel

Cat. No.	Product Name	Target	Signaling Pathways
T3S0081	Oxypeucedanin (+-)-Oxypeucedanin,氧化前胡素,Oxypeucadanin	Potassium Channel	Membrane transporter/Ion channel
	Oxypeucedanin ((+-)-Oxypeucedanin) 是呋喃香豆素衍生物，分离自Angelica dahurica。它是选择性开放通道阻滞剂，可抑制hKv1.5通道电流，IC50值为 76 nM。它延长心脏动作电位持续时间，是潜在的抗心律失常试剂。它通过抑制癌细胞迁移来诱导细胞凋亡。
T0801	Tannic acid 单宁酸,Gallotannic acid	Potassium Channel; HER; CXCR	Angiogenesis; Autophagy; GPCR/G Protein; Immunology/Inflammation; JAK/STAT signaling; Membrane transporter/Ion channel; Tyrosine Kinase/Adaptors
	Tannic acid (Gallotannic acid) 是新型hERG 通道阻塞剂，IC50为 3.4 μM。
T3054	Daurisoline 蝙蝠葛苏林碱,(R,R)-Daurisoline	Others; Potassium Channel; Autophagy	Autophagy; Membrane transporter/Ion channel; Others
	Daurisoline ((R,R)-Daurisoline) 是一种 hERG 抑制剂，也是一种自噬阻滞剂。
T23107	Ononetin 芒柄花酚,2',4'-Dihydroxy-2-(4-methoxyphenyl)acetophenone	TRP/TRPV Channel	Membrane transporter/Ion channel
	Ononetin (2',4'-Dihydroxy-2-(4-methoxyphenyl)acetophenone) 是天然脱氧安息香素，是有效的TRPM3 通道选择性阻断剂，IC50为 0.3 μM。
T6S0084	Tuberostemonine 对叶百部碱,Tuberstemonine	Parasite	Microbiology/Virology
	Tuberostemonine (Tuberstemonine) 是一种生物碱，可作为抗疟疾剂，有较高的肠道通透性。
T6631	Quinine hydrochloride dihydrate 奎宁单盐酸盐二水合物,Quinine HCl Dihydrate,奎宁盐酸盐二水合物	Potassium Channel; Parasite	Membrane transporter/Ion channel; Microbiology/Virology
	Quinine hydrochloride dihydrate (Quinine HCl Dihydrate) 是一种白色结晶 K+ 通道阻滞剂，用于治疗疟疾，具有退热，抗疟，止痛，抗炎等特性。
T0792	(-)-Sparteine sulfate pentahydrate (-)-Sparteine Sulfate,Lupinidine sulfate pentahydrate,(-)-Sparteine sulfate salt,sulfate pentahydrate,五水合硫酸司巴丁	Sodium Channel	Membrane transporter/Ion channel
	(-)-Sparteine sulfate pentahydrate ((-)-Sparteine Sulfate) 是一种生物碱，是钠通道抑制剂，属于1a 类抗心律失常药。
T16535	Picrotoxinin	Chloride channel; GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	Picrotoxinin 是一种氯离子通道阻断剂和 GABAA 的非竞争性拮抗剂，对 α1β2γ2L GABAA 的 IC50 为 1.15 μM。 Picrotoxinin 具有惊厥作用。
T3S0807	Berbamine	CaMK; NF-κB; Autophagy	Autophagy; Neuroscience; NF-κB
	Berbamine 是从黄柏中提取的一种天然产物，是钙通道阻滞剂，具有抗肿瘤、免疫调节和心血管作用。
T7853	(+)-Sparteine 鹰爪豆碱,(+)-鹰爪豆碱,Pachycarpine	AChR	Neuroscience
	(+)-Sparteine (Pachycarpine) 是从苏格兰扫帚中提取的一种生物碱，是钠通道阻滞剂和 1a 类抗心律失常剂。它在神经细胞中竞争性地抑制烟碱型乙酰胆碱受体活性，是神经节阻滞剂。
T8716	physalin F 酸浆苦味素F,酸浆苦素 F	Apoptosis	Apoptosis
	Physalin F 是一种分泌型甾体，诱导人外周血单个核细胞凋亡，降低人 T 淋巴细胞 1 型病毒感染后的自发增殖和细胞因子的产生，具有强烈抗炎和免疫调节作用。
TMA2106	(-)-Sparteine	P450	Metabolism
	Sparteine is a class 1a antiarrhythmic agent, a sodium channel blocker. The deficient debrisoquine hydroxylation of Sparteine is due to the absence of P-450IID1 protein in the livers of poor metabolizers.
T3029	Sparteine sulfate 硫酸司巴丁,Depasan,Tocosimplex,Actospar	Others; Sodium Channel	Membrane transporter/Ion channel; Others
	Sparteine sulfate (Tocosimplex) 是一种 1a 类抗心律失常药和钠通道阻滞剂。它可以螯合二价钙和镁。
T27191	D-Mannuronic Acid
	D-Mannuronic Acid is a blocker of the TLR2 and TLR4 downstream signaling pathway. D-Mannuronic Acid effectively inhibits mRNA expression of MyD88 and p65, major subunit of nuclear factor-kappaB.
T62265	(+)-Sparteine sulfate pentahydrate
	(+)-sparteine (sulfate pentahydrate) 是一种神经节阻断剂，可以竞争性阻断神经元中烟碱乙酰胆碱受体。
TN3636	Chlorahololide C	Potassium Channel	Membrane transporter/Ion channel
	Chlorahololide C is a potent and selective potassium channel blocker, it exerts potent and selective inhibition on the delayed rectifier (I(K)) K(+) current with the IC(50) value of 3.6 +/- 10.1 mu M.
T75722	Chlorotoxin TFA
	Chlorotoxin TFA，一种从蝎子毒液中分离出的多肽，作为氯离子通道 (chloride channel) 的阻断剂，具备抗癌活性。
T21266	Quinine sulfate
	Quinidine sulfate 是一种抗心律失常剂。Quinidine sulfate 是一种口服有效的、选择性的细胞色素 P450db (cytochrome P450db) 抑制剂。Quinidine sulfate 是 K+通道 (K+channel) 的有效阻断剂，IC50值为 19.9 μM。Quinidine sulfate 同时具有抗疟疾的研究潜力。
TN3587	Capillarisin	MMP; ERK; IL Receptor; BCL; VEGFR; TNF; NOS; NF-κB; TLR; MAPK; COX; DNA/RNA Synthesis; Prostaglandin Receptor; JNK; STAT	Angiogenesis; Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; GPCR/G Protein; Immunology/Inflammation; JAK/STAT signaling; MAPK; Neuroscience; NF-κB; Proteases/Proteasome; Stem Cells; Tyrosine Kinase/Adaptors
	Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cells, it inhibits cancer cell growth of osteosarcoma cells by inducing apoptosis accompanied with
TN5061	Stephanine	Adrenergic Receptor; Antifection	GPCR/G Protein; Microbiology/Virology; Neuroscience
	l-Stephanine is a potent and highly selective alpha 1 adrenoceptor blocker, inhibits anococcygeus muscle contraction induced by phenylephrine with pA2 values of 6.76. Stephanine shows significant antiplasmodial activities with IC(50) ranged from 1.2 uM to 52.3 uM. Stephanine and crebanine have high inhibitory activity against gram-positive animal pathogenic bacteria, with MIC values of 0.078-0.312g/l, but low inhibitory activity against gram-negative animal pathogenic bacteria, they also inhibit...
T75697	1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone
	1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone，为喹诺酮类生物碱，作用为二酰基甘油酰基转移酶抑制剂与血管紧张素II受体阻断剂，其IC50值依次为20.1 μM与34.1 μM。此化合物亦展现对幽门螺杆菌的有效抗活性，MIC值达10 μg/mL。

天然产物

Cat.No: T3S0081

Synonym: (+-)-Oxypeucedanin,氧化前胡素,Oxypeucadanin

Target: Potassium Channel

Cat.No: T0801

Synonym: 单宁酸,Gallotannic acid

Target: Potassium Channel, HER, CXCR

Cat.No: T3054

Synonym: 蝙蝠葛苏林碱,(R,R)-Daurisoline

Target: Others, Potassium Channel, Autophagy

Cat.No: T23107

Synonym: 芒柄花酚,2',4'-Dihydroxy-2-(4-methoxyphenyl)acetophenone

Target: TRP/TRPV Channel

Tuberostemonine

Cat.No: T6S0084

Synonym: 对叶百部碱,Tuberstemonine

Target: Parasite

Quinine hydrochloride dihydrate

Cat.No: T6631

Synonym: 奎宁单盐酸盐二水合物,Quinine HCl Dihydrate,奎宁盐酸盐二水合物

Target: Potassium Channel, Parasite

(-)-Sparteine sulfate pentahydrate

Cat.No: T0792

Synonym: (-)-Sparteine Sulfate,Lupinidine sulfate pentahydrate,(-)-Sparteine sulfate salt,sulfate pentahydrate,五水合硫酸司巴丁

Target: Sodium Channel

Cat.No: T16535

Target: Chloride channel, GABA Receptor

Cat.No: T3S0807

Target: CaMK, NF-κB, Autophagy

Cat.No: T7853

Synonym: 鹰爪豆碱,(+)-鹰爪豆碱,Pachycarpine

Target: AChR

Cat.No: T8716

Synonym: 酸浆苦味素F,酸浆苦素 F

Target: Apoptosis

Cat.No: TMA2106

Target: P450

Sparteine sulfate

Cat.No: T3029

Synonym: 硫酸司巴丁,Depasan,Tocosimplex,Actospar

Target: Others, Sodium Channel

D-Mannuronic Acid

Cat.No: T27191

(+)-Sparteine sulfate pentahydrate

Cat.No: T62265

Chlorahololide C

Cat.No: TN3636

Target: Potassium Channel

Chlorotoxin TFA

Cat.No: T75722

Quinine sulfate

Cat.No: T21266

Cat.No: TN3587

Target: MMP, ERK, IL Receptor, BCL, VEGFR, TNF, NOS, NF-κB, TLR, MAPK, COX, DNA/RNA Synthesis, Prostaglandin Receptor, JNK, STAT

Cat.No: TN5061

Target: Adrenergic Receptor, Antifection

1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone

Cat.No: T75697

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