Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Quinidine sulfate 是一种抗心律失常剂。Quinidine sulfate 是一种口服有效的、选择性的细胞色素 P450db (cytochrome P450db) 抑制剂。Quinidine sulfate 是 K+通道 (K+channel) 的有效阻断剂,IC50值为 19.9 μM。Quinidine sulfate 同时具有抗疟疾的研究潜力。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
25 mg | ¥ 10,600 | 6-8周 | ||
50 mg | ¥ 13,800 | 6-8周 | ||
100 mg | ¥ 17,500 | 6-8周 |
Quinine sulfate 的其他形式现货产品:
产品描述 | Quinidine is an antiarrhythmic agent. Quinidine is a potent, orally active, selective cytochrome P450db inhibitor. Quinidine is also a blocker of K + channel with an IC 50 of 19.9 μM. Quinidine has potential to be used for malaria research [1] [2] [3]. |
体外活性 | Quinidine sulfate is an anti-arrythmic drug which affects ionic currents in heart muscle. Quinidine sulfate has also been shown to be a potent blocker of several classes of K + channel in a variety of cell types [1]. Bath application of quinidine sulfate results in a dose-dependent reduction of the peak amplitude of I k. The K d for blockade of I k at 0 mV is estimated to be 41 μM [1]. Quinidine sulfate elicits a dose-dependent increase of the rate of the decay of I k and this effect is enhanced by membrane depolarization. Quinidine also causes a 5 mV hyperpolarizing shift of the steady-state inactivation curve and increases the half-time for recovery from inactivation. Quinidine does not affect the onset of inactivation measured at -30 mV [1]. |
体内活性 | Quinidine sulfate is rapidly absorbed, with peak plasma concentrations 60-90 min after an oral dose, while other salts (gluconate, polygalacturonate) are more slowly absorbed, with lower peak concentrations [2]. Quinidine sulfate is approximately 70-90 % bound to plasma proteins. It undergoes hepatic oxidative metabolism to form an N-oxide, a 3-hydroxy form, an O-demethyl form and 2'-quinidinone [2]. Quinidine sulfate inhibits metabolism of amphetamine in rats. Quinidine pretreatment results in a significant decrease in the excretion of p-hydroxyamphetamine at 24 and 48 h to 7.2 and 24.1% of the vehicle-control levels, respectively, accompanied by a significant increase in amphetamine excretion between 24 and 48 h to 542% of the control [3]. |
分子量 | 746.92 |
分子式 | C40H50N4O8S |
CAS No. | 804-63-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: Soluble
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Quinine sulfate 804-63-7 Quinine Sulfate Inhibitor inhibitor inhibit