Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Quinine hydrochloride dihydrate (Quinine HCl Dihydrate) 是一种白色结晶 K+ 通道阻滞剂,用于治疗疟疾,具有退热,抗疟,止痛,抗炎等特性。
产品描述 | Quinine hydrochloride dihydrate (Quinine HCl Dihydrate) is a white crystalline K+ channel blocker, used to treat malaria. |
体外活性 | Quinine blocks Cx36 and Cx50 junctional currents in a reversible and concentration-dependent manner with half maximal blocking concentrations of 32 mM and 73 mM, respectively. Quinine induces slow transitions between open and fully closed states that decreased open probability of the channel. Quinine thus offers a potentially useful method to block certain types of gap junction channels, including those between neurons that are formed by Cx36. [1] Quinine, a K+ channel blocker, prevents formation of tumor necrosis factor (TNF) as well as the subsequent hepatic DNA fragmentation and liver enzyme leakage. [2] Quinine elicits Fos-like immunoreactivity (FLI) concentrated in the medial third of the nucleus; acid elicited more broadly distributed FLI concentrated farther laterally. [3] Quinine has a relatively weak effect on doxorubicin accumulation but was able to completely restore doxorubicin sensitivity in the resistant cells. Quinine also modifies the intracellular tolerance to doxorubicin, which suggests that it is able to modify drug distribution within the cells. [4] Quinine primarily blocks the whole cell potassium currents (IK) in a voltage-dependent manner. Quinine also reduces the size of sodium currents (INa) in a use-dependent manner, while leaving calcium currents (ICa) relatively unaffected. [5] |
别名 | 奎宁单盐酸盐二水合物, Quinine HCl Dihydrate, 奎宁盐酸盐二水合物 |
分子量 | 396.91 |
分子式 | C20H24N2O2·HCl·2H2O |
CAS No. | 6119-47-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (125.97 mM)
Ethanol: 79 mg/mL (199.03 mM)
H2O: 43 mg/mL (108.33 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO / Ethanol / H2O | 1 mM | 2.5195 mL | 12.5973 mL | 25.1946 mL | 62.9866 mL |
5 mM | 0.5039 mL | 2.5195 mL | 5.0389 mL | 12.5973 mL | |
10 mM | 0.2519 mL | 1.2597 mL | 2.5195 mL | 6.2987 mL | |
20 mM | 0.126 mL | 0.6299 mL | 1.2597 mL | 3.1493 mL | |
50 mM | 0.0504 mL | 0.2519 mL | 0.5039 mL | 1.2597 mL | |
100 mM | 0.0252 mL | 0.126 mL | 0.2519 mL | 0.6299 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Quinine hydrochloride dihydrate 6119-47-7 Membrane transporter/Ion channel Microbiology/Virology Potassium Channel Parasite Quinine Hydrochloride Quinine HCl inhibit anti-malarial cinchonaine Inhibitor 奎宁单盐酸盐二水合物 Quinine hydrochloride Dihydrate Quinine Quinine HCl Dihydrate 奎宁盐酸盐二水合物 KcsA inhibitor