Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ononetin (2',4'-Dihydroxy-2-(4-methoxyphenyl)acetophenone) 是天然脱氧安息香素,是有效的TRPM3 通道选择性阻断剂,IC50为 0.3 μM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 218 | 现货 | ||
5 mg | ¥ 497 | 现货 | ||
10 mg | ¥ 747 | 现货 | ||
25 mg | ¥ 1,390 | 现货 | ||
50 mg | ¥ 1,990 | 现货 | ||
100 mg | ¥ 2,990 | 现货 | ||
200 mg | ¥ 4,390 | 现货 | ||
500 mg | ¥ 6,910 | 待询 |
产品描述 | Ononetin (2',4'-Dihydroxy-2-(4-methoxyphenyl)acetophenone) is a TRPM3 channel blocker(IC50: 0.3 μM). |
靶点活性 | TRPM3:0.3 μM |
体外活性 | Administration of 1-10 μM Ononetin completely and reversibly abrogates Ca2+ entry and ionic currents through recombinantly expressed TRPM3α2 and block the pregnenolone sulphate-inducible Ca2+ entry in primary cultures of mouse or rat dorsal root ganglia (DRG) neurones[1]. |
体内活性 | Intraperitoneal injection of 10 mg/kg Ononetin completely reverses established Freund's Complete Adjuvant (FCA)-induced heat hypersensitivity, demonstrating that the loss of hypersensitivity in Trpm3-/- mice is unlikely to be caused by developmental or compensatory mechanisms[2]. |
别名 | 芒柄花酚, 2',4'-Dihydroxy-2-(4-methoxyphenyl)acetophenone |
分子量 | 258.27 |
分子式 | C15H14O4 |
CAS No. | 487-49-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: < 30 mg/mL (116.16 mM)
Ethanol: < 30 mg/mL (116.16 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO / Ethanol | 1 mM | 3.8719 mL | 19.3596 mL | 38.7192 mL | 96.7979 mL |
5 mM | 0.7744 mL | 3.8719 mL | 7.7438 mL | 19.3596 mL | |
10 mM | 0.3872 mL | 1.936 mL | 3.8719 mL | 9.6798 mL | |
20 mM | 0.1936 mL | 0.968 mL | 1.936 mL | 4.8399 mL | |
50 mM | 0.0774 mL | 0.3872 mL | 0.7744 mL | 1.936 mL | |
100 mM | 0.0387 mL | 0.1936 mL | 0.3872 mL | 0.968 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Ononetin 487-49-0 Membrane transporter/Ion channel TRP/TRPV Channel Inhibitor Transient receptor potential channels 芒柄花酚 inhibit Ca2+ TRP Channel 2',4'-Dihydroxy-2-(4-methoxyphenyl)acetophenone TRPM3 deoxybenzoin inhibitor