2157
129
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T60063 |
Fluorogen binding modulator-1
Fluorogen binding modulator-1 |
Others | Others |
Fluorogen binding modulator-1 (Fluorogen binding modulator-1)是一种氟-氟激活蛋白结合对的非荧光抑制剂。 | |||
T67737 |
gp120-α4β7 binding inhibitor 11
|
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
gp120-α4β7 binding inhibitor 11是一种抗HIV 药物。gp120-α4β7 binding inhibitor 11干扰HIV 相关糖蛋白gp12G 与整合素α4β7的结合(IC50=1.64nM)。 | |||
TP1736L |
Fibrinogen-Binding Peptide 137235-80-4(fb-acetate)
|
Others | Others |
Fibrinogen-Binding Peptide 137235-80-4(fb-acetate) 是纤维蛋白原受体上玻连蛋白结合位点的推定肽模拟物。它结合纤维蛋白原并抑制血小板与纤维蛋白原的粘附和血小板聚集,还抑制血小板与玻连蛋白的粘附 | |||
T40361 |
Integrin Binding Peptide
|
||
Integrin Binding Peptide, derived from fibronectin, holds the potential as an essential component for preparing PEG hydrogels. | |||
T18595 |
Dasatinib carbaldehyde
PROTAC ABL binding moiety 4,BMS-354825 carbaldehyde |
Others; Ligands for Target Protein for PROTAC | Others; PROTAC |
Dasatinib carbaldehyde (PROTAC ABL binding moiety 4) 基于 ABL 抑制剂达沙替尼,通过接头与 IAP 配体结合,形成 SNIPER [1]。 | |||
TP2360 |
A2-Binding peptide
|
||
A2-Binding peptide has involved in the assembly of MHC Class I molecules. | |||
TP1120 |
Interphotoreceptor Retinoid Binding Protein Fragment (IRBP)
IRBP,Interphotoreceptor Retinoid Binding Protein Fragment IRBP |
||
Interphotoreceptor Retinoid Binding Protein Fragment (IRBP) is a 20-residue peptide, which is a major pathogenic epitope. It exists in the first homologous repeat of interstitial visual pigment Binding Protein peptide (IRBP 161-180) and can induce post-uv | |||
TP1736 |
Fibrinogen-Binding Peptide
|
||
Fibrinogen-Binding Peptide (designed by anticomplementarity hypothesis) is a presumptive peptide mimic of the vitronectin binding site on the fibrinogen receptor. Fibrinogen, a soluble plasma protein, is a cofactor in platelet activation. It is converted | |||
T13915L |
PROTAC BRD9-binding moiety 1 hydrochloride
PROTAC BRD9-binding moiety 1 hydrochloride (2097512-23-5 free base) |
Others | Others |
PROTAC BRD9-binding moiety 1 hydrochloride binds to BRD9, and used for inhibiting BRD9 activity, based on PROTAC. | |||
TP1710 |
Calmodulin Binding Peptide 1
|
||
Calmodulin Binding Peptide 1, a potent CaM-binding peptide with picomolar (pM) affinity, originates from smooth muscle myosin light-chain kinase (MLCK peptide). It effectively blocks inositol trisphosphate (IP3)-induced calcium (Ca2+) release [1]. | |||
TP1120L |
IRBP acetate(211426-18-5 free base)
Interphotoreceptor Retinoid Binding Protein Fragment IRBP |
Others | Others |
IRBP acetate(211426-18-5 free base) (Interphotoreceptor Retinoid Binding Protein Fragment IRBP) 是一种含有 20 个残基的肽,是一种主要的致病表位。它存在于间质视觉色素结合蛋白肽(IRBP 161-180)的第一个同源重复序列中,可诱导葡萄膜炎后(EAU)。 | |||
TP1778 |
Fibrinogen Binding Inhibitor Peptide
|
||
Fibrinogen Binding Inhibitor Peptide, a synthetic dodecapeptide, represents the specific platelet receptor recognition site of the human fibrinogen g-chain (residues 400-411). | |||
T13841 |
PROTAC Her3-binding moiety 1
|
Others | Others |
PROTAC Her3-binding moiety 1 is a Her3 Ligand for PROTAC. | |||
T13915 |
PROTAC BRD9-binding moiety 1
|
Epigenetic Reader Domain | Chromatin/Epigenetic |
PROTAC BRD9-binding moiety 1 that binds to BRD9, and used for inhibiting BRD9 activity, based on PROTAC. | |||
T18599 |
PROTAC BRD4-binding moiety 1
|
Others | Others |
PROTAC BRD4-binding moiety 1 is a BRD4 ligand that binds to the cereblon ligand through a linker, enabling the formation of a PROTAC complex. This complex efficiently degrades BRD4[1]. | |||
T12557 |
PROTAC BET-binding moiety 1
|
Others | Others |
PROTAC BET-binding moiety 1 is a key intermediate in the synthesis of high affinity BET inhibitors | |||
T12558 | PROTAC BET-binding moiety 2 | Others | Others |
PROTAC BET-binding moiety 2 is an BET bromodomain inhibitor. | |||
TP1153L |
Fibronectin Adhesion-promoting Peptide acetate
Fibronectin Adhesion-promoting Peptide acetate(125720-21-0 free base),Heparin Binding Peptide acetate |
Others | Others |
Fibronectin Adhesion-promoting Peptide acetate (Heparin Binding Peptide acetate)(125720-21-0 free base) 是在纤连蛋白的羧基末端肝素结合结构域中发现的肝素结合氨基酸序列之一。 | |||
TP2254 |
GTP-Binding Protein Fragment, G alpha
|
Others | Others |
Using specific antisera raised against synthetic peptides, we find that three distinct GTP-binding protein alpha subunits remain bound to the plasma membrane even after activation with nonhydrolyzable GTP analog. Trypsin cleaves each alpha subunit at a si | |||
TP1119 |
Interphotoreceptor retinoid-binding protein(668-687)
IRBP(668-687) |
||
Interphotoreceptor retinoid-binding protein(668-687)is an amino acid residue of human retinoid-binding protein(IRBP) 668-687, which can induce uveitis. | |||
T76542 |
ErbB-2-binding peptide
|
||
ErbB-2-binding peptide (HER2-binding peptide)为具结合肿瘤功能的肽类,其在癌症研究中显示出应用潜力。 | |||
TP2302 |
vitamin D binding protein precursor (353-363) [Homo sapiens]
|
Others | Others |
Human vitamin D-binding protein (hDBP) is an abundant, multifunctional, and highly polymorphic serum glycoprotein synthesized by the liver1. | |||
T82151 |
Hyaluronan-binding peptide, biotin labeled
|
||
Hyaluronan-binding peptide, biotin labeled 是通过 C 端 GGGSK 残基生物素化的透明质酸结合肽,能够干预 HA 与 CD44 受体的作用,并阻碍 T 细胞增殖。 HA 在细胞外基质和细胞表面广泛表达,参与多种生物过程,包括受精、胚胎发育、伤口修复、血管新生、炎症反应和肿瘤转移。 | |||
T76527 |
Hepatitis B Virus Receptor Binding Fragment
|
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Hepatitis B Virus Receptor Binding Fragment(hepatitis B peptide 4980)为一合成肽类似物,特异性结合Hep G2细胞。基于病毒中和粘附阻断理念,此Fragment可望激发保护性抗体生成,展现作为免疫原的巨大潜力。 | |||
TP2299 |
tumor protein p53 binding protein fragment [Homo sapiens]/[Mus musculus]
|
Others | Others |
Tumor protein p53 binding protein (53BP1) has been identified in a yeast two-hybrid screen as a protein that interacts with the central DNA–binding domain of p532. Similar to breast cancer susceptibility gene 13, 4 (BRCA1; 53BP1 enhances p53-dependent tra | |||
T74256 | PROTAC BRD9-binding moiety 5 | ||
PROTACBRD9-binding moiety 5 是一种选择性 BRD9结合剂,IC50为 4.20 μM,可用于合成 PROTACs。PROTACBRD9-binding moiety 5 对癌细胞具有抗增殖活性。 | |||
TP2190 |
vitamin D binding protein precrusor (208-218) [Homo sapiens]/[Oryctolagus cuniculus]
|
Others | Others |
Vitamin D-binding protein is a multifunctional, highly expressed, polymorphic serum protein. These range from the transport of vitamin D metabolites to possible roles in the immune system and host defense. The molecular weight range, the time course of ap | |||
TP1153 |
Fibronectin Adhesion-promoting Peptide
Heparin Binding Peptide |
||
Fibronectin Adhesion-promoting Peptide (Heparin Binding Peptide) is one of the heparin-binding amino acid sequences found in the carboxy-terminal heparin-binding domain of fibronectin. | |||
T80233 |
p53 CBS
p53 Consensus binding sequence |
||
p53 CBS(p53共有DNA结合位点)是一种具备生物活性的肽类化合物。 | |||
T82059 |
Interphotoreceptor retinoid-binding protein(668-687) TFA
IRBP(668-687) TFA |
||
Interphotoreceptor retinoid-binding protein(668-687) TFA 为光受体视黄醇结合蛋白的668至687氨基酸片段,具有诱发葡萄膜炎的能力。 | |||
T80992 |
Thrombospondin (TSP-1)-derived CD36 binding motif
|
||
Thrombospondin (TSP-1)-derived CD36 binding motif 是一种源自基质结合糖蛋白TSP-1的生物活性肽,具备与CD36相互作用的关键结合基序。该肽通过二硫键形成环状结构,与癌症转移、肿瘤粘附和新血管形成等过程相关。研究表明,它能竞争性抑制血小板聚集和肿瘤转移。 | |||
T83742 |
SBP1 TFA
Spike Binding Peptide 1 |
||
Spike binding peptide 1 (SBP1) 为对应于血管紧张素转换酶2 (ACE2) 的第21至43位氨基酸的肽。已将脂质纳米粒子 (LNPs) 包裹的抗病毒化合物奥司他韦磷酸盐与SBP1结合并通过体外研究评估其控制释放奥司他韦磷酸盐的长期潜力。SBP1 (2%) 固定于交联的羟基丙烯酸酯和乙基黄原酸乙酯网络,提高了对严重急性呼吸系统冠状病毒2(SARS-CoV-2)刺突糖蛋白,亦称表面糖蛋白,的网络捕获效率。 | |||
T18612 |
Bestatin-amido-Me
PROTAC IAP binding moiety 1 |
Others | Others |
Bestatin-amido-Me, a derivative of Bestatin, acts as an IAP ligand and interacts with ABL inhibitor through a linker to produce SNIPER[1]. | |||
T18641 |
SirReal1-O-propargyl
PROTAC Sirt2-binding moiety 1 |
Others | Others |
SirReal1-O-propargyl is a selective and highly potent Sirtuin 2 (Sirt2) inhibitor, with an IC50 of 2.4 μM. SirReal1-O-propargyl, the SirReal1-based moiety, binds to the cereblon ligand via a linker to form PROTAC to degrade Sirt2[1]. | |||
T76566 |
Fsh receptor-binding inhibitor fragment(bi-10)
|
||
FSHreceptor-binding inhibitor fragment(bi-10) 是一种有效的 FSH 拮抗剂。FSHreceptor-binding inhibitor fragment(bi-10) 阻断 FSH 与 FSHR 的结合,并在受体水平上改变 FSH 的作用。FSHreceptor-binding inhibitor fragment(bi-10) 导致小鼠排卵抑制和卵泡闭锁。FSHreceptor-binding inhibitor fragment(bi-10) 通过下调卵巢中 FSHR 和 ERβ的过度表达来抑制卵巢癌发生。 | |||
T83756 |
S1H TFA
Site 1-binding Helix |
||
S1H是一种人造肽类模拟物,模仿人类生长激素的第36至51个氨基酸,且为生长激素受体的拮抗剂。在溶液中呈现α-螺旋结构,并在100和200纳摩尔(nM)的浓度下,能降低SK-MEL-28和MALME-3M黑色素瘤细胞系以及IM-9 B细胞淋巴细胞中,由人类生长激素及泌乳素诱导的STAT5磷酸化。 | |||
TP1152 |
Fibronectin Adhesion-promoting Peptide TFA
Heparin Binding Peptide TFA |
||
Fibronectin Adhesion-promoting Peptide (Heparin Binding Peptide) is one of the heparin-binding amino acid sequences found in the carboxy-terminal heparin-binding domain of fibronectin. It promotes assembly of mesenchymal stem cell (MSC) spheroids into lar | |||
T19172 |
A-1210477-piperazinyl
PROTAC Mcl1-binding moiety 1 |
Others | Others |
A-1210477-piperazinyl is a compound that specifically targets and binds to the protein myeloid cell leukemia 1 (MCL1). This compound is utilized in PROTAC technology, which harnesses the ability to selectively degrade target proteins. | |||
T18601 |
Desmethyl-QCA276
PROTAC BRD4-binding moiety 4 |
Others | Others |
Desmethyl-QCA276, the QCA276-based moiety, binds to cereblon ligand via a linker to form PROTAC to degrade BET. QCA276 is a BET inhibitor with an IC50 of 10 nM, and with a Ki of 2.3 nM[1]. | |||
T13914 |
SLF-amido-C2-COOH
PROTAC FKBP12-binding moiety 1 |
Others | Others |
SLF-amido-C2-COOH is a synthetic ligand for FKBP (SLF), and can be used in the synthesis of PROTACs. | |||
T18613 |
MV-1-NH-Me
PROTAC IAP binding moiety 2 |
Others | Others |
MV-1-NH-Me, an MV-1-derived IAP ligand, connects to an ABL inhibitor through a linker, resulting in the formation of SNIPER[1]. | |||
T18594 |
HG-7-85-01-Decyclopropane
PROTAC ABL binding moiety 3 |
Others | Others |
Decyclopropane, also known as HG-7-85-01, is a chemical compound with ABL inhibitor properties. It binds to the IAP ligand through a linker, resulting in the formation of SNIPER [1]. | |||
T81356 |
PTBP1-RNA-binding inhibitor P6 TFA
PTBP1 α3-helix derived peptide P6 TFA |
||
PTBP1-RNA-binding inhibitor P6 (PTBP1 α3-helix derived peptide P6) TFA 为剪接因子PTBP1的特定钉合肽抑制剂,用于抑制PTBP1调控的RNA选择性剪接事件。该抑制剂通过与PTBP1的RNA识别基序相结合,从而发挥其作用。 | |||
T18593 |
GNF5-amido-Me
PROTAC ABL binding moiety 2 |
Others | Others |
GNF5-amido-Me, the moiety based on GNF5 (ABL inhibitor),binds through a linker to the IAP ligand forming SNIPER[1]. | |||
T18611 |
AP1867-2-(carboxymethoxy)
PROTAC FKBP12-binding moiety 2 |
Others | Others |
AP1867-2-(carboxymethoxy), a moiety based on the synthetic FKBP12F36V-directed ligand AP1867, connects to the CRBN ligand through a linker to generate dTAG molecules[1]. | |||
T83729 |
Tat-CIRP TFA
Tat-Cold-inducible RNA Binding Protein |
||
Tat-CIRP是一种肽类抑制剂,用于抑制髓样分化2蛋白(MD-2,亦称淋巴细胞抗原96 [LY96])与寒冷诱导的RNA结合蛋白(CIRP)之间的蛋白-蛋白相互作用。它通过与MD-2结合,干扰MD-2与CIRP之间的相互作用,这一作用在共免疫沉淀实验中得到证实。在体内实验中,Tat-CIRP (10及20 mg/kg) 能够减少由中脑动脉闭塞(MCAO)引发的小鼠脑梗死体积。同样,在通过血栓引发脑梗死的恒河猴模型中,Tat-CIRP同样能减少脑梗死体积,并缩短患中风一侧手臂抓取并放下食物的时间。 | |||
T37473 |
SBFI AM
Sodium-binding Benzofuran Isophthalate Acetoxymethyl ester |
||
SBFI AM is a membrane-permeant, fluorescent Na+ indicator dye. It is selective for Na+ over K+ with Kd values of 20 and 120 mM for these ions, respectively. [1]Increasing concentration of Na+ increases the ratio of excitation efficiency at 330-345 nm to that at 370-390 nm with emission collected at 450-550 nm. [1] Therefore, ratio fluorometry and imaging can be performed with the same wavelengths. SBF AM is suitable for single intracellular dye injection and is typically used for high-resolutio... | |||
T15585 |
IRBP(668-687) (TFA)
Interphotoreceptor retinoid-binding protein(668-687) TFA |
Others | Others |
Interphotoreceptor retinoid-binding protein TFA is the amino acid residue 668 to 687 of human interphotoreceptor retinoid-binding protein (IRBP). It also induces uveitis. | |||
T14298 |
Rimiducid
|
Apoptosis; Others; Fatty Acid Synthase | Apoptosis; Metabolism; Others |
Rimiducid 是一种可渗透脂质的他克莫司类似物,是一种二聚剂,通过交联 FKBP 结构域起作用。它将 Caspase 9 自杀开关二聚化并迅速诱导细胞凋亡。 | |||
T83193 |
Acetyl-Heme-Binding Protein 1 (1-21) (human)
|
||
Acetyl-Heme-Binding Protein 1 (1-21) (human)为一种由Acetyl-Heme-Binding Protein 1前21个氨基酸组成的短肽。该肽具有与血红素结合的能力,参与血红素代谢及血红蛋白释放过程。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TWS1977 |
Kamebakaurin
尾叶香茶菜丙素,Kamebakaurine |
NF-κB | NF-κB |
Kamebakaurin (Kamebakaurine) 是一种提取自Isodon japonicus 中的天然产物,是一种NF-κB 的抑制剂,能够抑制 p50 的 DNA 结合活性。 | |||
T6995 |
Ochromycinone
STA 21,STA21,STA-21 |
Antibacterial; STAT | JAK/STAT signaling; Microbiology/Virology; Stem Cells |
Ochromycinone (STA 21) 是一种天然抗生素,也是一种 STAT3抑制剂。它可抑制 STAT3DNA 结合活性,STAT3二聚化。它具有抗癌和抗菌活性。 | |||
T2144 |
Tacrolimus
他克莫司,Fujimycin,FK506,FR900506 |
Phosphatase; Others; Antibacterial; Antibiotic; mTOR; Autophagy | Autophagy; Metabolism; Microbiology/Virology; Others; PI3K/Akt/mTOR signaling |
Tacrolimus (Fujimycin) 可与 FKBP12 结合形成高亲和力复合物 (Ki: 0.2 nM),抑制钙/钙调蛋白依赖性蛋白磷酸酶的活性。 | |||
T6569 |
Mimosine
Leucenine,NSC 69188,含羞草素,Leucenol,L-Mimosine |
Others | Others |
Mimosine (Leucenol) 是一种酪氨酸类似物,具有抗癌和抗炎等活性。它可通过其强大的铁结合活性作为抗氧化剂,是一种 Fe(III) 螯合剂。它作用于人类白血病细胞,通过金属离子螯合、线粒体激活和诱导活性氧产生来诱导细胞凋亡。 | |||
T2481 |
Ascomycin
FK520,Immunomycin,子囊霉素,FR-900520 |
Phosphatase; Others; Antibiotic; Parasite; Antifungal | Metabolism; Microbiology/Virology; Others |
Ascomycin (Immunomycin) 是 Tacrolimus 的乙基类似物,具有免疫抑制特性。它也是一种大环聚酮类抗生素,具有抗疟疾、抗真菌和抗痉挛等多种生物活性。它可防止移植排斥,并具有用于各种皮肤病研究的潜力。 | |||
T1537 |
Rapamycin
Sirolimus,AY 22989,雷帕霉素,NSC-2260804 |
Others; Endogenous Metabolite; Antibiotic; mTOR; Autophagy; Antifungal | Autophagy; Metabolism; Microbiology/Virology; Others; PI3K/Akt/mTOR signaling |
Rapamycin (AY 22989) 属于大环内酯类天然产物,是一种 mTOR 抑制剂,具有特异性(HEK293 细胞:IC50=0.1 nM)。Rapamycin 具有免疫抑制活性,并能诱导自噬。 | |||
T20879 |
Tacrolimus monohydrate
FK-506,FR 900506,Prograf,FR900506,Tacrolimus hydrate,LCP-Tacro,他克莫司一水合物,FK 506 |
Phosphatase; Others; Antibacterial; Antibiotic; Autophagy | Autophagy; Metabolism; Microbiology/Virology; Others |
Tacrolimus monohydrate (LCP-Tacro) 是大环内酯类化合物,它与 FK506 结合蛋白 (FKBP) 结合形成复合物并抑制钙调神经磷酸酶,从而抑制 T 淋巴细胞信号转导和 IL-2 转录。具有强免疫抑制特性。 | |||
TN1653 |
Fustin
|
ERK; Beta Amyloid; AChR | MAPK; Neuroscience |
Fustin 是植物漆树 (Rhus verniciflua Stokes) 的植物性黄烷醇成分。 Fustin 对 6-羟基多巴胺诱导的神经元细胞死亡具有保护作用。 | |||
T5S0273 |
Hypaphorine
Lenticin,Glyyunnanenine,Tryptophan Betaine,刺桐碱 |
Others | Others |
Hypaphorine (Lenticin) 是一种提取自 Pisolithus tinctorius 中的吲哚类生物碱,对啮齿动物具有有神经学影响降糖活性。 | |||
T21351 |
Maytansine
NSC-153858,NSC153858,Maitansina,NSC 153858,Maitansine,美坦新 |
Microtubule Associated; Antibiotic | Cytoskeletal Signaling; Microbiology/Virology |
Maytansine (NSC-153858) 是从变叶美登木中分离的一种高效微管靶向天然产物,可诱导有丝分裂阻滞并在亚纳摩尔浓度杀死肿瘤细胞。 | |||
TN6722 |
Terminolic acid
2α,6β,23-trihydroxyl oleanolic acid |
Antibacterial | Microbiology/Virology |
Terminolic acid (2α,6β,23-trihydroxyl oleanolic acid) 是一种从 Combretum racemosum 中分离得到的五环三萜糖苷,可通过与 IL-1β 和 IL-6 的受体活性位点结合抑制促炎细胞因子,并通过与 IL-4 受体结合位点结合增强抗炎细胞因子。它还表现出适度的抗菌活性。 | |||
T7097 |
Cytochalasin B
Phomin,细胞松弛素 B,细胞松弛素B |
Arp2/3 Complex | Cytoskeletal Signaling |
Cytochalasin B is a mycotoxin binding to the barbed end of actin filaments. It can disrupt the formation of actin polymers (Kd: 1.4-2.2 nM for F-actin). | |||
T4839 |
Ac-Ala-OH
N-Acetylalanine,N-Acetyl-L-alanine,N-乙酰-L-丙氨酸 |
Others; Endogenous Metabolite | Metabolism; Others |
Ac-Ala-OH (N-Acetyl-L-alanine) 是鸟嘌呤核苷酸结合蛋白G(I)/G(S)/G(O) γ -2亚基、髓鞘碱性蛋白、GTP-结合核蛋白 Ran、原肌球蛋白 α - 4链、HIV-1 Rev 结合蛋白2、Xaa-Pro 二肽酶、胸腺酶 β -10、肌动蛋白样蛋白3、丙氨酸转氨酶、丝氨酸/苏氨酸蛋白磷酸酶PP1 - β催化亚基、10 kda 热休克蛋白(线粒体)、钙调蛋白和 β -1-syntrophin 的底物。 | |||
T13592 |
Calf thymus DNA
DNA from calf thymus, Thymonucleic acid |
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
Calf thymus DNA (DNA from calf thymus, Thymonucleic acid) 是一种从牛胸腺中提取出来的高质量双链模板DNA,可广泛应用于DNA 结合抗癌剂和调节DNA 结构和功能的DNA 结合剂的研究。 | |||
TN1202 |
(-)-α-Pinene
左旋-α-蒎烯,左旋-alpha-蒎烯,(1S)-(-)-Alpha-Pinene |
Virus Protease; GABA Receptor; Endogenous Metabolite; Antibacterial | Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience |
(-)-α-Pinene ((1S)-(-)-Alpha-Pinene) 是一种单萜类化合物,通过延长 GABAergic 突触传递、作为 GABAA-BZD 受体的部分调节剂并直接与 GABAA 受体的 BZD 结合位点结合来增强 NREMS 的数量而不影响 NREMS 的强度。 | |||
T0912L |
Tetracycline
Deschlorobiomycin,Tetracyclinum,Tetracyclin,四环素 |
Others; ribosome; Antibacterial; Antibiotic | Microbiology/Virology; Others |
Tetracycline (Tetracyclin) 是一种对多种革兰氏阳性和革兰氏阴性细菌有抑制活性的广谱抗生素。 | |||
T30086 |
Anthragallol
Anthragallic acid,1,2,3-Trihydroxyanthraquinone |
Others | Others |
Anthragallol(1,2,3-Trihydroxyanthraquinone) 通过与 DNA 结合而显示出细胞毒性。Anthragallol 可作为分析试剂,可用于生产棕色酸洗色料。 | |||
T16552 |
Pleuromutilin
Mutilin 14-glycolate,Drosophilin B,截短侧耳素 |
Antibacterial; Antibiotic | Microbiology/Virology |
Pleuromutilin (Drosophilin B) 通过与细菌的 50S 核糖体亚基结合来抑制细菌蛋白质的合成。 | |||
T1653 |
Liothyronine
Tresitope,O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine,碘噻罗宁,Triiodothyronine,三碘甲状腺原氨酸,L-3,3',5-Triiodothyronine,3,3',5-Triiodo-L-thyronine,Lyothyronine |
Thyroid hormone receptor(THR); Endogenous Metabolite | Endocrinology/Hormones; Metabolism |
Liothyronine (Tresitope) 是一种有效的甲状腺激素,能够激活 β1 甲状腺激素受体 (TRβ1)。 | |||
T5855 |
Edrophonium chloride
|
AChE | Neuroscience |
Edrophonium chloride 是一种乙酰胆碱酯酶抑制剂,可通过特异性结合其催化位点来防止神经递质乙酰胆碱的分解。 | |||
T3806 |
kaempferide
Kaempferol 4'-O-methyl ether,山奈素,Kaempferol 4'-methyl ether,4'-Methylkaempferol,4'-O-Methylkaempferol |
Estrogen Receptor/ERR; Estrogen/progestogen Receptor; Influenza Virus; Antibacterial; Autophagy | Autophagy; Endocrinology/Hormones; Microbiology/Virology |
kaempferide (4'-Methylkaempferol) 是一种存在于山柰中的O-甲基化黄酮醇,具有抗病毒活性。 | |||
T4727 |
Taurolithocholic acid sodium salt
牛磺石胆酸钠,Sodium taurolithocholate |
Others; Calcium Channel | Membrane transporter/Ion channel; Metabolism; Others |
Taurolithocholic acid sodium salt (Sodium taurolithocholate) 是抑胆剂和 Ca2+激动剂,可抑制放射性配体与毒蕈碱 M1 结合。 | |||
T5081 |
Adenine monohydrochloride hemihydrate
腺嘌呤盐酸盐,Adenine hydrochloride hydrate,6-Aminopurine hydrochloride hydrate |
Endogenous Metabolite; Adenosine Receptor | GPCR/G Protein; Metabolism; Neuroscience |
Adenine monohydrochloride hemihydrate 是内源性代谢产物的一种。 | |||
TJS1183 |
Cyclen
轮环藤宁,1,4,7,10-tetraazacyclododecane |
Others | Others |
Cyclen (1,4,7,10-tetraazacyclododecane) 是一种氮杂冠醚的类似物,是制备有效的大环螯合物的中间体,是制备磁共振造影剂的前体物质。 | |||
TN6779 |
Clausine E
|
Others | Others |
Clausine E 是脂肪量和肥胖相关蛋白 (FTO) 脱甲基酶活性的抑制剂。 Clausine E 与 FTO 的结合是由正熵和负焓变化驱动的。 | |||
T2219 |
Puromycin dihydrochloride
CL13900 dihydrochloride,Puromycin 2HCl,嘌呤霉素二盐酸盐水合物,嘌呤霉素二盐酸盐 |
ribosome; DNA/RNA Synthesis; Antibacterial; Antibiotic | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology |
Puromycin dihydrochloride (CL13900 dihydrochloride) 属于肉桂酰胺腺苷抗生素,是一种蛋白质合成的抑制剂。Puromycin dihydrochloride 通过与 RNA 结合来抑制蛋白质合成,具有抗肿瘤和抗锥虫活性。 | |||
T13502 |
3-Oxo-5β-cholanoic acid
3-氧代-5β-胆烷酸,Dehydrolithocholic acid |
ROR | Metabolism |
3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid) 是胆汁酸的一种代谢产物。3-Oxo-5β-cholanoic acid 直接与关键转录因子RORγt(Kd=1.13 μM) 结合抑制TH17细胞分化。 | |||
TN2165 |
Rubrofusarin gentiobioside
Rubrofusarin-6-O-beta-D-gentiobioside,红链霉素-龙胆二糖苷,芸苔红素龙胆苷 |
ERK; NF-κB; TGF-beta/Smad | MAPK; NF-κB; Stem Cells |
Rubrofusarin gentiobioside (Rubrofusarin-6-O-beta-D-gentiobioside) 一种分离自决明子的、具有清除自由基作用的化合物。 | |||
T3810 |
Saikosaponin B2
柴胡皂苷 B2,柴胡皂甙 B2 |
Others; HCV Protease | Microbiology/Virology; Others; Proteases/Proteasome |
Saikosaponin B2 是从柴胡根中分离得到的一种活性成分,可抑制 HCV 病毒感染的侵入,有抗癌作用。 | |||
TN2030 |
P-Hydroxyphenethyl trans-ferulate
反式-阿魏酸对羟基苯乙酯 |
5-HT Receptor | GPCR/G Protein; Neuroscience |
p-Hydroxyphenethyl trans-ferulate 具有抗高血糖 (酵母α-葡萄糖苷酶,IC5019.24 ± 1.73 µmol L-1),抗氧化,抗炎活性,也具有抗癌特性和血清素能特性。 | |||
T3829 |
Ginsenoside F3
人参皂苷F3 |
Others; IFNAR; Interleukin | Immunology/Inflammation; Others |
Ginsenoside F3 是一种皂苷,提取自Panax ginseng 叶片。它能够调节1 型 (IL-2, IFN-γ) 及 2 型细胞因子(IL-4 and IL-10) 的产生和表达,有免疫增强的作用。 | |||
TN2269 |
Tetramethylcurcumin
|
Apoptosis; STAT | Apoptosis; JAK/STAT signaling; Stem Cells |
Tetramethylcurcumin 是一种新型姜黄素类似物,是一种有效的 STAT3 磷酸化、DNA 结合活性和体外反式激活抑制剂。它具有抗炎和抗癌作用。 | |||
T21430 |
Oxytetracycline Hydrochloride
Biosolvomycin,盐酸土霉素,Oxytetracycline HCl,Oxytetracycline.HCl,Dalimycin,Oxytetracycline, Sodium Salt,Dalinmycin |
Antiviral; Endogenous Metabolite; Antibacterial; HSV | Immunology/Inflammation; Metabolism; Microbiology/Virology |
Oxytetracycline Hydrochloride (Dalimycin) 是由 Streptomyces rimosus 生产的,一种具有抗菌活性的四环素衍生物。它干扰氨酰-tRNA 与 mRNA-核糖体复合物的结合,从而阻止肽延伸并抑制蛋白质合成。 | |||
T65128 |
Tartaric acid disodium dihydrate
Disodium L-(+)-Tartrate Dihydrate |
Phosphatase; Endogenous Metabolite | Metabolism |
Tartaric acid disodium dihydrate (Disodium L-(+)-Tartrate Dihydrate) 常用来制作分子生物学和细胞培养中的缓冲液,。Tartaric acid disodium dihydrate 是酸性磷酸酶抑制剂, 可增加秋水仙碱结合 tubulin1的概率。 | |||
T7054 |
N-Benzoyl-(2R,3S)-3-phenylisoserine
N-苯甲酰基-(2R,3S)-3-苯基异丝氨酸,taxol side chain |
Antiviral | Immunology/Inflammation |
N-Benzoyl-(2R,3S)-3-phenylisoserine (taxol side chain) 是一种制备用于研究结合位点位置的强效抗癌药物紫杉醇的中间体。 它显示出细胞毒性、抗病毒和免疫调节活性。 | |||
TN1325 |
(2S)-6-Prenylnaringenin
(2S)-6-异戊烯基柚皮素,6-异戊二烯基柚皮素,6-Prenylnaringenin,6-PN |
GABA Receptor | Membrane transporter/Ion channel; Neuroscience |
(2S)-6-Prenylnaringenin (6-Prenylnaringenin) 是强效植物雌激素 8-prenylnaringenin 的异构体,是前脑中最有效的化合物,在 α+β 结合位点上起GABAA 正变构调节剂的作用。 | |||
T6389 |
Anacardic Acid
漆树酸,6-pentadecylsalicylic Acid,Hydroginkgolic acid |
Others; Epigenetic Reader Domain; Histone Acetyltransferase; Antibacterial | Chromatin/Epigenetic; Microbiology/Virology; Others |
Anacardic Acid (6-pentadecylsalicylic Acid) 是从腰果壳中提取液中分离到的酸类物质,是一种组蛋白乙酰转移酶抑制剂,对 p300 和 PCAF 的 IC50值分别为 ∼8.5 μM 和 ∼5 μM。 | |||
T4717 |
25-Hydroxycholesterol
25-羟基胆固醇,25-羟基胆甾醇 |
Others; Endogenous Metabolite; HMG-CoA Reductase | Metabolism; Others |
25-Hydroxycholesterol 是胆固醇的代谢产物,由巨噬细胞响应 Toll 样受体激活而分泌。它有效抑制 B 细胞产生 IgA,EC50约为 65 nM。 | |||
T2S0633 |
Raspberry ketone
Oxyphenalon,Rasketone,Aloenin,4-(4-Hydroxyphenyl)-2-butanone,p-Hydroxybenzyl acetone,Frambinone,覆盆子酮 |
PPAR | DNA Damage/DNA Repair; Metabolism |
Raspberry ketone (p-Hydroxybenzyl acetone) 是覆盆子中主要的芳香族天然产物,主要用作化妆品的香料和食品增味剂,也可作 PPAR-α激动剂。 | |||
TN7235 |
4-methoxylonchocarpin
|
TNF; NF-κB | Apoptosis; NF-κB |
4-methoxylonchocarpin 是从Abrus precatorius 的根中分离出来的以一种有效的抗炎化合物。4-methoxylonchocarpin 通过抑制LPS 与巨噬细胞的TLR4结合来抑制NF-κB 激活TNF 表达,抑制TNBS 引起的小鼠结肠炎。 | |||
T20939 |
Bimatoprost acid
17-phenyl trinor PGF2α,17-phenyl trinor Prostaglandin F2α |
GPR | Endocrinology/Hormones; GPCR/G Protein |
Bimatoprost acid (17-phenyl trinor PGF2α) 是一种代谢稳定的 PGF2α 类似物,对 FP 受体具有潜在的拮抗活性。与 PGF2α 相比,它与绵羊黄体细胞上的 FP 受体结合的相对效力为 756%。 | |||
T6228 |
Irinotecan
CPT-11,Topotecin,伊立替康,(+)-Irinotecan |
Topoisomerase; Autophagy | Autophagy; DNA Damage/DNA Repair |
Irinotecan (CPT-11) 是喜树碱的衍生物,是一种 DNA 拓扑异构酶 I (Topo I) 的抑制剂。Irinotecan 通过与 Topo I 复合物结合来阻止 DNA 链的重新连接,并导致双链 DNA 断裂和细胞死亡,具有抗肿瘤活性。 | |||
T1304 |
Chlortetracycline hydrochloride
Isphamycin,Chlortetracycline HCl,7-Chlorotetracycline hydrochloride,盐酸金霉素 |
ribosome; Antibacterial; Antibiotic | Microbiology/Virology |
Chlortetracycline hydrochloride (Isphamycin) 是一种特异性钙离子载体抗生素, 抑制氨酰 tRNA 结合到核糖体。 | |||
T5530 |
Mithramycin A
Plicamycin |
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
Mithramycin A (Plicamycin) 是一种dna 结合的抗肿瘤抗生素,选择性特异性蛋白1 (Sp1)抑制剂,通过降低Sp1蛋白抑制多种肿瘤的生长。特异性蛋白1 (Sp1)是一种锌指转录因子,调节多种细胞功能,促进肿瘤进展。 | |||
T4893 |
Spermidine
N-(3-Aminopropyl)-1,4-diaminobutane,亚精胺,N-(4-Aminobutyl)-1,3-diaminopropane |
Endogenous Metabolite | Metabolism |
Spermidine (N-(3-Aminopropyl)-1,4-diaminobutane) 能够维持细胞膜稳定性,提高抗氧化酶活性,改善光系统 II 以及相关基因表达。它结合并激活 NMDA,并已显示以浓度依赖性方式增强 NMDA 诱导的电流。 | |||
T3862 |
Irigenin
|
NF-κB; Integrin | Cytoskeletal Signaling; NF-κB |
Irigenin 可通过特异性和选择性地阻断 Extra Domain A 域的 C-C 环上α9β1和α4β1整合素结合位点,介导其抗转移作用。可通过增强胃癌细胞中促凋亡分子的表达来敏化 TRAIL 诱导的凋亡,具有抗癌作用。 | |||
T0912 |
Tetracycline hydrochloride
NCI-c55561,盐酸四环素,Tetracycline HCl |
ribosome; Antibacterial; Antibiotic | Microbiology/Virology |
Tetracycline hydrochloride (NCI-c55561) 是一种广谱抗生素,抑制多种革兰氏阳性和革兰氏阴性细菌。 | |||
T5244 |
Aminomalonic acid
2-Aminopropanedioic Acid,氨基丙二酸,Aminomalonate |
Others; Endogenous Metabolite | Metabolism; Others |
Aminomalonic acid (Aminomalonate) 是氨基内源性代谢产物,在体外能作为来源 Leukemia 5178Y/AR 和小鼠胰腺的 L- 天冬酰胺合成酶的高效抑制剂 (Leukemia 5178Y/AR:Ki= 0.0023 M,小鼠胰腺:Ki= 0.0015 M)。它有潜力用作区分黑素瘤转移的不同阶段生物标志物。 | |||
T5S0994 |
N-Methylcytisine
N-甲基野靛碱,Caulophylline |
Others; AChR | Neuroscience; Others |
N-Methylcytisine (Caulophylline) 是苦参中的一种三环喹啉类生物碱,具有降血糖、缓解疼痛和抗炎活性。它是中枢神经系统中乙酰胆碱烟碱受体的选择性配体,对鱿鱼视神经节中的烟碱乙酰胆碱受体具有很高的亲和力,Kd 为 50 nM。 | |||
T2220 |
2-Methoxyestradiol
2-甲氧雌二醇,二甲氧基雌二醇,NSC-659853,2-MeOE2,2-ME2 |
Apoptosis; Reactive Oxygen Species; Microtubule Associated; Endogenous Metabolite; HIF; Autophagy | Angiogenesis; Apoptosis; Autophagy; Chromatin/Epigenetic; Cytoskeletal Signaling; Immunology/Inflammation; Metabolism; NF-κB |
2-Methoxyestradiol (2-ME2) 是一种口服生物可利用的雌二醇代谢物,具有抗肿瘤活性。它通过减少内皮细胞增殖和诱导内皮细胞凋亡来抑制血管生成,也可破坏微管的稳定。它可诱导半胱天冬酶活化,导致细胞周期停滞在 G2 期、DNA 断裂和细胞凋亡。 | |||
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