338
42
18
36
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TP2146 |
JTP10-△-TATi TFA
|
JNK | MAPK |
JTP10-△-TATi TFA is a selective inhibitor of JNK2 peptide (IC50: 92 nM), exhibiting 10-fold selectivity for JNK2 over JNK1 and JNK3. | |||
TP1035L |
Cyclic somatostatin Acetate(38916-34-6(free base))
Somatostatin (sheep), monoacetate (salt),Somatostatin-14,SRIF-14,monoacetate (salt) |
Others | Others |
Cyclic somatostatin Acetate(38916-34-6(free base)) (Somatostatin-14) 是一种环状十四肽,可调节许多内分泌和神经系统功能。 | |||
T36848 |
Combretastatin A-1
Combretastatin A1 |
Akt; Microtubule Associated | Cytoskeletal Signaling; PI3K/Akt/mTOR signaling |
Combretastatin A-1 是一种有效的微管抑制剂,具有抗肿瘤和抗血管活性,通过微管蛋白解聚介导的 AKT 失活抑制 Wnt/β-catenin 通路发挥作用,可用于研究肝癌。 | |||
T7504 |
Necrostatin 2 racemate
5-[(7-氯-1H-吲哚-3-基)甲基]-3-甲基-2,4-咪唑烷二酮,Necrostatin-2 racemate |
RIP kinase | Apoptosis; NF-κB |
Necrostatin 2 racemate (Necrostatin-2 racemate) 是一种特异性的RIPK1抑制剂,是一种稳定型 Nec-1。 | |||
T25276 |
Crilvastatin
PMD387,PMD 387,PMD-387 |
HMG-CoA Reductase | Metabolism |
Crilvastatin (PMD 387) 是一种新型非竞争性羟甲基戊二酰辅酶 A 还原酶抑制剂,具有降胆固醇活性,可抑制遗传性高胆固醇血症大鼠的胆固醇吸收。 | |||
T1676 |
Rosuvastatin
罗伐他汀,ZD 4522,瑞舒伐他汀 |
Potassium Channel; HMG-CoA Reductase; Autophagy | Autophagy; Membrane transporter/Ion channel; Metabolism |
Rosuvastatin (ZD 4522) 是一种抗血脂药,可竞争性抑制羟甲基戊二酰辅酶 A 还原酶,用于降低血浆胆固醇水平和预防心血管疾病。它降低低密度脂蛋白胆固醇、甘油三酯和 C-反应蛋白水平。它阻断人类醚-a-go-go 相关基因电流,IC50为 195 nM,延迟心脏复极化,延长动作电位持续时间和校正 QT 间期间隔。 | |||
T3116 |
Atorvastatin hemicalcium salt
Lipitor,Atorvastatin hemicalcium,Atorvastatin Calcium,CI-981,阿托伐他汀钙,Sortis |
Ferroptosis; HMG-CoA Reductase; Autophagy | Apoptosis; Autophagy; Metabolism |
Atorvastatin hemicalcium salt (Atorvastatin Calcium) 是一种口服有效的 HMG-CoA 还原酶抑制剂 ,可用作降低胆固醇的药物。它抑制人 SV-SMC 增殖和侵袭,IC50分别为 0.39 μM 和 2.39 μM。 | |||
TP2180L |
Compstatin control peptide acetate
|
Complement System | Immunology/Inflammation |
Compstatin control peptide acetate 是补体蛋白 C3 的抑制剂,通过结合和抑制补体 C3 的切割。 | |||
T11013L1 |
Dextrorotation nimorazole phosphate ester TFA
|
Others | Others |
Dextrorotation nimorazole phosphate ester TFA 是一种抗厌氧菌和抗原虫感染的试剂。 | |||
T67735 |
Auristatin23
|
Others | Others |
Auristatin23是一种抗肿瘤试剂。Auristatin23对肿瘤细胞系具有抗增殖活性。 | |||
TP1571L |
Allatostatin II acetate(123374-34-5 free base)
|
Others | Others |
Allatostatin II acetate(123374-34-5 free base) 用于昆虫保幼激素合成抑制剂。 | |||
TP2057L |
Camstatin acetate
|
NO Synthase | Immunology/Inflammation |
Camstatin acetate 结合钙调蛋白并抑制神经元一氧化氮合酶。它是 PEP-19 的单一钙调蛋白结合 IQ 基序的具有功能活性的 25 个残基片段。 | |||
T71812 |
Protonstatin-1
|
||
Protonstatin-1可用作降糖剂和治疗阿尔茨海默病的化合物,可抑制IGFIR 激酶的活性,可用于研究癌症。 | |||
T21550 |
Blebbistatin
(±)-Blebbistatin |
ATPase; Myosin | Cytoskeletal Signaling; Membrane transporter/Ion channel |
Blebbistatin ((±)-Blebbistatin) 是一种选择性的非肌肉肌球蛋白 II 抑制剂,可促进角膜内皮细胞 (CEC) 的定向迁移并加速伤口愈合,并保留了细胞连接的完整性和屏障功能。 | |||
T6500 |
Ferrostatin-1
Ferrostatin 1,Ferrostatin-1 (Fer-1) |
Ferroptosis; Antifungal | Apoptosis; Microbiology/Virology |
Ferrostatin-1 (Fer-1) 是一种铁死亡抑制剂,具有强效性和选择性。Ferrostatin-1 有效抑制 Erastin 诱导的 HT-1080 细胞铁死亡 (EC50=60 nM)。Ferrostatin-1 还具抗氧化和抗真菌活性。 | |||
T77841 |
Duostatin 5
|
Others | Others |
Duostatin 5 (Duo-5)是一种海兔毒素类似物,常用于合成 ADC 化合物。 | |||
T12490 |
Pitavastatin lactone
|
Others | Others |
Pitavastatin lactone 是 Pitavastatin 在人体中的主要代谢产物。Pitavastatin 是 HMG-CoA 还原酶竞争性抑制剂。 | |||
T2164 |
Wiskostatin
|
Others | Others |
Wiskostatin 是神经元 Wiskott-Aldrich 综合征蛋白介导的肌动蛋白聚合的选择性抑制剂,能够不可逆的使细胞 ATP 水平快速下降。 | |||
T6161 |
Tubastatin A Hydrochloride
TSA HCl,Tubastatin A HCl |
Apoptosis; HDAC; Autophagy | Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair |
Tubastatin A Hydrochloride (TSA HCl) 是一种选择性的 HDAC6抑制剂,IC50值为 15 nM,对其选择性是 HDAC8 外的其他亚型的 1000 多倍。 | |||
T30745L |
Carboxy-pyridostatin 2HCl
Carboxy-pyridostatin 2HCl(1417638-60-8 Free base) |
DNA | DNA Damage/DNA Repair |
Carboxy-pyridostatin 2HCl 具有潜在的抗肿瘤活性,在 DNA G4s 上对 DNA 具有很高的亲和力。 | |||
T4457 |
Pyridostatin Trihydrochloride
Pyridostatin Trihydrochloride(free base 1085412-37-8 ),RR-82 Trihydrochloride |
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
Pyridostatin Trihydrochloride (RR-82 Trihydrochloride) 是一种 G-四链体稳定剂,Kd 为 490 nM。 | |||
TP1570L |
Cortistatin-14 acetate
Cortistatin-14 acetate(186901-48-4 Free base) |
Somatostatin | GPCR/G Protein |
Cortistatin-14 acetate 是一种与生长抑素-14结构相似的神经肽,通过生长抑素受体 (sst1-sst5) 结合并发挥作用。Cortistatin-14 acetate 具有抗惊厥、神经保护作用和显著的抗炎作用。 | |||
T20887 |
Atorvastatin Sodium
Lipitor |
LDL; Aquaporin; HMG-CoA Reductase | Membrane transporter/Ion channel; Metabolism |
Atorvastatin Sodium (Lipitor) 是一种HMG-CoA 还原酶的竞争性抑制剂,增加肝细胞上低密度脂蛋白(LDL)受体的表达。Atorvastatin sodium 处理抑制水汽蛋白4来减轻缺血性脑水肿。 | |||
T27240 |
Eeyarestatin I
|
Apoptosis | Apoptosis |
Eeyarestatin I 是具有抑制内质网相关蛋白质降解和蛋白易位的抑制剂。Eeyarestatin I 与p97去泛素过程相关,抑制atx3的去泛素化。Eeyarestatin I 通过诱导蛋白质使细胞死亡,具有抗癌作用。 | |||
T10324 |
Anhydrosimvastatin
Dehydro simvastatin,脱水辛伐他汀 |
HMG-CoA Reductase | Metabolism |
Anhydrosimvastatin (Dehydro simvastatin) 是 Simvastatin 的一种杂质。其中Simvastatin 是竞争性的 HMG-CoA 还原酶抑制剂。 | |||
TP1741L |
Histatin 5 acetate
Histatin 5 acetate (115966-68-2 Free base) |
MMP | Proteases/Proteasome |
Histatin 5 acetate 抑制宿主基质金属蛋白酶 MMP-2 和 MMP-9 的活性,IC50 分别为 0.57 和 0.25 μM。 | |||
T9268 |
Ulinastatin
|
Others | Others |
Ulinastatin 是一种多价 Kunitz 型丝氨酸蛋白酶抑制剂,具有抗炎特性。 | |||
T3695 |
Pepstatin
抑肽素,Pepstatin A,Pepsin Inhibitor S 735A,Ahpatinin C |
Amino Acids and Derivatives; Proteasome; HIV Protease; Autophagy | Autophagy; Metabolism; Microbiology/Virology; Proteases/Proteasome; Ubiquitination |
Pepstatin (Pepsin Inhibitor S 735A) 是由放线菌类产生的特异性天冬氨酸蛋白酶抑制剂,可抑制 HIV 蛋白酶的活性。 | |||
T6040 |
Aloxistatin
E64d,Loxistatin,阿洛司他丁,E64c ethyl ester |
SARS-CoV; Cysteine Protease | Microbiology/Virology; Proteases/Proteasome |
Aloxistatin (E64d) 是一种不可逆的、可透过膜的溶酶体和细胞溶质半胱氨酸蛋白酶抑制剂,能够抑制完整血小板中的钙蛋白酶活性。它是一种半胱氨酸蛋白酶抑制剂,具有血小板聚集抑制活性。 | |||
T38470 |
Obestatin (human)
|
||
Obestatin (human) 是一种由 preproghrelin 经过剪切形成的G蛋白欧联实体39的内源性配体,可以剂量依赖的方式抑制进食,可用于研究肥胖。 | |||
T9079 |
Apostatin-1
Apt-1 |
Others | Others |
Apostatin-1 (Apt-1) 是一种新型 TRADD 抑制剂。 Apostatin-1 可以与 TRADD 的 N 末端 TRAF2 结合域上的口袋结合。 | |||
T5195 |
Alrestatin
阿瑞司他丁,AY-22284 |
Reductase | Endocrinology/Hormones; Metabolism |
Alrestatin (AY-22284) 是醛糖还原酶的特异性抑制剂,能够在体外减弱大鼠血管平滑肌中葡萄糖诱导的血管紧张素 II 的产生。 | |||
TP1304 |
Compstatin
坎普他汀 |
Complement System | Immunology/Inflammation |
Compstatin 是一种环状十三肽,是补体系统 C3的特异性抑制剂。它只抑制灵长类补体系统的激活,可结合到狒狒的 C3,并对狒狒血液中的蛋白水解裂解具有抗性。它对补体经典途径和旁路途径的 IC50值分别为 63 和 12 μM。 | |||
T9266 |
Fatostatin
|
Lipid; Fatty Acid Synthase | Metabolism |
Fatostatin A 是一种SREBP 活化的特异性抑制剂,能够抑制 SREBP-1 和 SREBP-2 的活化。它与 SCAP (SREBP 裂解激活蛋白) 结合,抑制 SREBPs 的 ER-Golgi 易位。它具有抗肿瘤活性,能抑制ob/ob 小鼠的高血糖。它抑制细胞中成脂基因的转录。 | |||
T1875 |
Atglistatin
|
Lipase | Metabolism |
Atglistatin 是脂肪甘油三酯脂酶的选择性抑制剂(IC50:0.7 μM),在体外具有抑制脂解的功能。 | |||
T2583 |
Cilastatin
西司他丁,MK0791 |
Proteasome; Antibacterial; Antibiotic | Microbiology/Virology; Proteases/Proteasome; Ubiquitination |
Cilastatin (MK0791) 是一种可逆的竞争性的肾脏脱氢肽酶 I 抑制剂,IC50为 0.1 μM。它抑制细菌金属叶内酰胺酶CphA 的IC50为 178 μM,可用作抗菌辅助剂。 | |||
TP1790L |
Tyr-Somatostatin-14 acetate(58100-03-1 free base)
|
Others | Others |
Tyr-Somatostatin-14 acetate(58100-03-1 free base) 是一种定制肽,可在 Somatostatin-14 中添加酪氨酸氨基酸。 | |||
T11013L2 |
Levorotation nimorazole phosphate ester TFA
|
Others | Others |
Levorotation nimorazole phosphate ester TFA 是一种抗厌氧菌和抗原虫感染的试剂。 | |||
TP2056L |
Acetyl-Calpastatin (184-210)(human) acetate
Acetyl-Calpastatin (184-210) (human) acetate(123714-50-1 Free base ) |
Cysteine Protease | Proteases/Proteasome |
Acetyl-Calpastatin (184-210)(human) acetate 是一种有效,选择性和可逆的钙蛋白酶 (calpain) 抑制剂,对 μ-钙蛋白酶和组织蛋白酶 L 的 Ki 值分别为 0.2 nM 和 6 μM。 | |||
TP1658L |
Type A Allatostatin I acetate
Type A Allatostatin I acetate(123209-95-0 free base) |
Others | Others |
Type A Allatostatin I acetate(123209-95-0 free base) 是一种十三肽。 Allatostatin 是多效性神经肽,用于抑制昆虫保幼激素的合成。 | |||
T8536 |
Filastatin
|
Antifungal | Microbiology/Virology |
Filastatin 是一种长效的白色念珠菌丝状体抑制剂,具有强大的抗真菌作用。它抑制真菌与聚苯乙烯和人类细胞的粘附,从酵母到菌丝的形态转变,抑制菌丝特异性 HWP1 启动子。 | |||
T9095 |
Necrostatin-34
2-{[3-cyano-4-(4-methylphenyl)-6-oxo-1,4 |
RIP kinase | Apoptosis; NF-κB |
Necrostatin-34 (2-{[3-cyano-4-(4-methylphenyl)-6-oxo-1,4) 是一种 RIPK1 激酶抑制剂,通过在激酶结构域中占据一个独特的结合口袋,将 RIPK1 激酶稳定在非活性构象中。 | |||
TP1035 |
Cyclic somatostatin
SRIF-14,合成生长抑素,环状生长激素抑制素,Somatostatin-14 |
Others | Others |
Cyclic somatostatin (SRIF-14) 是生长激素释放抑制因子,可用于研究胃十二指肠溃疡出血。 | |||
T25859 |
Necrostatin-7
Necrostatin 7,Necrostatin7,Nec 7,Nec-7,Nec7 |
Apoptosis | Apoptosis |
Necrostatin-7 (Necrostatin 7) 是一种坏死性凋亡抑制剂,具有心脏保护作用,可抑制 RANK-NFATc1 信号传导并减弱巨噬细胞向破骨细胞的分化。 | |||
T20736 |
Cryptating agent 222
Cryptate 222,NSC 264495,NSC-264495,NSC264495 |
Others | Others |
Cryptating agent 222 (NSC-264495) 是穴状配体,与钾镜一起使用以将受阻二锡烯还原为结晶自由基阴离子并与金属阳离子形成配体。 | |||
T12503 |
(+)-Blebbistatin
|
Others | Others |
(+)-Blebbistatin 是 (–)-Blebbistatin 的非活性对映异构体。 (–)-Blebbistatin 是一种选择性肌球蛋白 II ATPase 抑制剂。 | |||
T8823 |
Locostatin
|
Raf | MAPK |
Locostatin 是一种有效的细胞渗透性 Raf 激酶抑制剂蛋白 (RKIP)/Raf1 激酶相互作用抑制剂和细胞迁移抑制剂。 | |||
TQ0045 |
2-Hydroxy atorvastatin calcium salt
|
Drug Metabolite | Metabolism |
2-Hydroxy atorvastatin calcium salt 是 Atorvastatin 钙盐的羟基代谢物,Atorvastatin 是一种有效的 HMG-CoA 还原酶抑制剂 (IC50 = 8 nM)。 | |||
T12652 |
(Rac)-5-Keto Fluvastatin
5-Ketofluvastatin,3-Hydroxy-5-Keto Fluvastatin,rac 5-Keto Fluvastatin |
Others | Others |
(Rac)-5-Keto Fluvastatin (rac 5-Keto Fluvastatin) 是 Fluvastatin 的杂质,Fluvastatin 是一种 HMG-CoA 还原酶的抑制剂。 | |||
TP2236L |
Cortistatin-8 acetate
Cortistatin-8 acetate(485803-62-1 Free base) |
GHSR | GPCR/G Protein |
Cortistatin-8 acetate 是一种皮质抑素类似物,是一种GHS-R拮抗剂,对生长激素促分泌素受体有抑制作用。Cortistatin-8 acetate 是一种合成皮质抑素衍生的生长素释放肽受体配体,不会改变人类对酰化生长素释放肽或海沙瑞林的内分泌反应。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T0687 |
Simvastatin
辛伐他汀,MK-0733,MK 733 |
Apoptosis; Mitophagy; Ferroptosis; HMG-CoA Reductase; Autophagy | Apoptosis; Autophagy; Metabolism |
Simvastatin (MK 733) 是一种 HMG-CoA 还原酶抑制剂 (Ki=0.2 nM),具有口服活性。Simvastatin 具有降血脂活性,可以抑制肝脏产生胆固醇,还可以用于预防心血管疾病。 | |||
T1678 |
Nystatin
Stamycin,Fungicidin,制霉菌素,Nystavescent |
Apoptosis; Antibiotic; Antifungal | Apoptosis; Microbiology/Virology |
Nystatin (Fungicidin) 是一种口服对酵母和支原体有效的多烯类抗真菌抗生素。它能增加质膜对包括氯离子等小单价离子的通透性。它可部分阻止 Oxaliplatin 诱导的脂筏聚集、DR4 和 DR5 聚集的胆固醇隔离试剂,减少细胞凋亡。 | |||
T0672 |
Pravastatin sodium
CS-514 Sodium,普伐他汀钠,CS-514 (sodium) |
Ferroptosis; HMG-CoA Reductase; Autophagy | Apoptosis; Autophagy; Metabolism |
Pravastatin sodium (CS-514 (sodium)) 是一种 HMG-CoA 还原酶抑制剂,抑制甾醇合成,IC50 为 5.6 μM。 | |||
T1207 |
Lovastatin
MK-803,洛伐他汀,Mevinolin |
Ferroptosis; HMG-CoA Reductase; Autophagy | Apoptosis; Autophagy; Metabolism |
Lovastatin (MK-803) 是一种 HMG-CoA 还原酶抑制剂,用于降低胆固醇。 | |||
T1257 |
Bestatin
Ubenimex,乌苯美司 |
Others; Aminopeptidase; Antibacterial; Antibiotic; LTR | Immunology/Inflammation; Metabolism; Microbiology/Virology; Others |
Bestatin (Ubenimex) 是 CD13 (Aminopeptidase N)/APN 和 leukotriene A4 hydrolase 抑制剂,可用于癌症研究。 | |||
T3529 |
Bestatin hydrochloride
盐酸乌苯美司,Ubenimex hydrochloride,苯丁抑制素 |
Integrin; Aminopeptidase; Antibacterial; Antibiotic | Cytoskeletal Signaling; Metabolism; Microbiology/Virology |
Bestatin hydrochloride (Ubenimex hydrochloride) 是CD13(Aminopeptidase N)/APN 和leukotriene A4 hydrolase 抑制剂,可研究癌症。 | |||
T6270 |
Trichostatin A
曲古柳菌素A,曲古抑菌素A,TSA |
HDAC | Chromatin/Epigenetic; DNA Damage/DNA Repair |
Trichostatin A (TSA) 属于二烯异羟肟酸类的天然衍生物。Trichostatin A 是一种组蛋白去乙酰化酶抑制剂 (IC50=1.8 nM),具有可逆性和特异性。Trichostatin A 导致核心组蛋白过度乙酰化,从而调节染色质结构。 | |||
TP1180 |
Dolastatin 10
尾海兔素10,NSC 376128,DLS 10 |
Microtubule Associated | Cytoskeletal Signaling |
Dolastatin 10 (DLS 10) 是一种多肽,可以抑制微管蛋白聚合,显示除抗有丝分裂的活性。 | |||
T6212 |
Combretastatin A4
CA4,康普瑞汀,Z)-3,4,5,4',-四甲氧基-3'-羟基二苯乙烯,CRC 87-09 |
Microtubule Associated | Cytoskeletal Signaling |
Combretastatin A4 (CA4) 是一种微管靶向剂,可结合 β-tubulin,Kd 值为 0.4 μM。 | |||
T0683 |
Mevastatin
Compactin,ML236B,美伐他汀 |
Apoptosis; Antibacterial; Antibiotic; HMG-CoA Reductase; Autophagy; Lipid | Apoptosis; Autophagy; Metabolism; Microbiology/Virology |
Mevastatin (ML236B) 是他汀类 HMG-CoA 还原酶抑制剂。它是一种降脂药,可诱导细胞凋亡,将癌细胞阻滞在 G0/G1期。它还可增加内皮型一氧化氮合酶的 mRNA 和蛋白质水平。它有抗肿瘤活性,用于心血管疾病的研究。 | |||
T16885 |
Simvastatin acid ammonium
辛伐他汀铵盐,Tenivastatin ammonium |
Others | Others |
Simvastatin ammonium is an active metabolite of simvastatin lactone mediated. Simvastatin ammonium reduces indoxyl sulfate-mediated reactive oxygen species and modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 ge | |||
T75638 | Himastatin | ||
Himastatin 是一种具有抗肿瘤活性的抗生素,由S. hygroscopicus sp 菌株产生。Himastatin 是一种二聚环六肽,含有哌嗪酸和一个独特的芳香族中心。 | |||
T26358 |
(-)-Agelastatin A
|
||
(-)-Agelastatin A inhibits osteopontin-mediated adhesion, invasion, and colony formation. | |||
TN6085 |
6-Methoxyspirotryprostatin B
Spirotryprostatin G |
||
6-Methoxyspirotryprostatin B 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN6085,CAS号为 1031727-28-2。 | |||
TN6083 |
Spirotryprostatin A
|
||
Spirotryprostatin A 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN6083,CAS号为 182234-25-9。 | |||
T39071 |
Thailanstatin D
|
||
Thailanstatin D, an analogue of Thailanstatin A, inhibits AR-V7 gene splicing by disrupting the interaction between U2AF65 and SAP155, hindering their binding to the polypyrimidine tract situated between the branch point and the 3' splice site. This compound displays potent tumor inhibitory properties in human castration-resistant prostate cancer (CRPC) xenografts, resulting in cellular apoptosis. | |||
T83158 |
Agistatin D
|
||
Agistatin D,一种从镰刀菌属分离得到的吡喃缩醛类化合物,具有抑制胆固醇生物合成(cholesterolbiosynthesis)的功能。 | |||
TN5190 |
Tryprostatin A
|
Topoisomerase; Antifection | DNA Damage/DNA Repair; Microbiology/Virology |
Tryprostatin A is an inhibitor of breast cancer resistance protein. Tryprostatin A and tryprostatin B are indole alkaloid-based fungal products that inhibit mammalian cell cycle at the G2/M phase. | |||
TN3290 |
8-O-Demethyl-7-O-methyl-3,9-dihydropunctatin
|
Others | Others |
8-O-Demethyl-7-O-methyl-3,9-dihydropunctatin 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN3290,CAS号为 93078-83-2。 | |||
T83157 |
Agistatin E
|
||
Agistatin E是镰刀菌属分离得到的一种吡喃缩醛类化合物,具有抑制胆固醇生物合成(cholesterolbiosynthesis)的功能。 | |||
T83606 |
(-)-β-Peltatin-5-O-beta-D-glucopyranoside
|
||
(-)-β-Peltatin-5-O-beta-D-glucopyranoside为自P. peltatum L中分离出的活性化合物。 | |||
T83864 |
Plipastatin A1
SNA-60-367-3,Fengycin IX |
||
Plipastatin A1是一种在B. cereus中发现的脂肽类化合物,具有酶抑制活性和免疫抑制活性。它能抑制磷脂酶A2(PLA2)、PLC和PLD(IC50分别为2.9、1.3和1.4 µM)。Plipastatin A1(100 µg/ml)能抑制LPS诱导的B细胞爆发生成和Concanavalin A诱导的T细胞爆发生成。在体内,Plipastatin A1(0.1 mg/动物)能抑制小鼠的迟发型超敏反应。 | |||
T73954 | Leucinostatin (mixture of A&B) | ||
Leucinostatin (mixture of A&B) 是来自Paecilomyces lilacinus 的九肽类复合物,具有抗生素活性。 | |||
T38890 |
Thailanstatin C
|
||
Thailanstatin C, an antiproliferative agent derived from Burkholderia thailandensis MSMB43, functions as a potent inhibitor of pre-mRNA splicing (IC50 = 6.84 μM). | |||
T62258 |
Bestatin trifluoroacetate
|
||
Bestatin trifluoroacetate (Ubenimex trifluoroacetate) 是一种 CD13 (Aminopeptidase N)/APN 和 leukotriene A4 hydrolase 抑制剂,经常用于研究癌症。 | |||
T20441 |
Lipstatin
|
||
Lipstatin is a potent inhibitor of the pancreas lipase. It is reported to be useful in the treatment and/or prevention of obesity and related diseases. | |||
T37055 |
Cytostatin
|
||
Cytostatin is a natural antitumor inhibitor of cell adhesion to extracellular matrix, blocking adhesion of B16 melanoma cells to laminin and collagen type IV in vitro (IC50s = 1.3 and 1.4 μg/ml, respectively) and B16 cells metastatic activity in mice. It induces apoptosis of FS3 mouse fibrosarcoma cells (IC50 = 3.1 μg/ml). Cytostatin potently and selectively inhibits protein phosphatase 2A (PP2A; IC50 = 29 nM against the catalytic subunit), while having no effect against PP1, PP2B, or PP5. | |||
T73640 |
Pancratistatin
|
||
Pancratistatin 是一种异喹啉生物碱,可以从蜘蛛兰 Hymenocallis littoralis 中分离。Pancratistatin 诱导人黑素瘤细胞凋亡。Pancratistatin 可用于神经母细胞瘤、白血病、和乳腺癌的研究。 | |||
T36295 | Echistatin TFA | ||
Echistatin TFA, the smallest active RGD protein belonging to the family of disintegrins that are derived from snake venoms, is a potent inhibitor of platelet aggregation. Echistatin is a potent inhibitor of bone resorption in culture. Echistatin is a potent antagonist of αIIbβ3, αvβ3 and α5β1[1][2][3][4]. [1]. J Musial, et al. Inhibition of platelet adhesion to surfaces of extracorporeal circuits by disintegrins. RGD-containing peptides from viper venoms. Circulation. 1990 Jul;82(1):261-73.[2]. ... | |||
T83159 |
Agistatin B
|
||
Agistatin B是从真菌中分离出的霉菌毒素,能够抑制胆固醇合成(cholesterolsynthesis)。 | |||
T75705 |
Pepstatin Trifluoroacetate
|
||
Pepstatin (Pepstatin A) Trifluoroacetate 是一种由放线菌产生的特异性天冬氨酸蛋白酶(aspartic proteases)抑制剂,口服活性强。该化合物能有效抑制hemoglobin-pepsin、hemoglobin-proctase、casein-pepsin、casein-proctase、casein-acid protease和hemoglobin-acid protease的活性,其IC50值分别为4.5 nM、6.2 nM、150 nM、290 nM、520 nM和260 nM。此外,对HIV protease也有抑制作用。 | |||
T6913 |
Nystatin A3
制霉菌素 A3,制霉菌素,Fungicidin,Nystatin |
Others | Others |
Nystatin A3 (Fungicidin) 是从Streptomyces noursei 中产生的一种多烯类抗真菌药,用作治疗口咽念珠菌病的外用剂。 | |||
TN3390 |
alpha-Peltatin
|
Others | Others |
alpha-Peltatin 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN3390,CAS号为 568-53-6。 | |||
T38069 |
Aquastatin A
|
||
Aquastatin A is a fungal metabolite originally isolated fromF. aquaeductuumthat has diverse biological activities.1It is active againstS. aureus(MIC = 32 μg/ml) and inhibits enoyl-acyl carrier protein reductase (Fabl; IC50= 3.2 μM) andS. aureusfatty acid synthesis (IC50= 3.5 μM).2Aquastatin A also inhibits the Na+/K+-ATPase and H+/K+-ATPase (IC50s = 7.1 and 6.2 μM, respectively), as well as protein tyrosine phosphatase 1B (PTP1B; IC50= 0.19 μM).1,3 1.Hamano, K., Kinoshita-Okami, M., Minagawa, K.... | |||
T72964 |
Dictyostatin
Dictyostatin 1,(-)-Dictyostatin ; Dictyostatin 1,(-)-Dictyostatin |
||
Dictyostatin ((-)-Dictyostatin ; Dictyostatin 1) 是一种有效的微管稳定剂。 Dictyostatin 也是一种抗癌剂。 Dictyostatin 具有抗增殖活性。Dictyostatin 具有研究 tauopathies 的潜力。 | |||
TN3794 |
Dehydroaglaiastatin
|
Others | Others |
Dehydroaglaiastatin是一种天然产物,属于楝科米仔兰属,其产品编号为 TN3794,CAS号为 155595-93-0。Dehydroaglaiastatin可用作对照参考。 | |||
TN2948 |
3'-Hydroxydehydroaglaiastatin
|
Others | Others |
3'-Hydroxydehydroaglaiastatin 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN2948,CAS号为 259143-58-3。 | |||
T26167 |
Rubropunctatin
Rubropunctamine |
||
Rubropunctatin is a monascus pigment with very potent cancer cell proliferation inhibitory effects. | |||
T14831 |
Bryostatin 1
|
HIV Protease; PKC | Chromatin/Epigenetic; Cytoskeletal Signaling; Microbiology/Virology; Proteases/Proteasome |
Bryostatin 1 is a natural macrolide isolated from the bryozoan Bugula neritina and is a CNS)permeable PKC modulator. Bryostatin 1 binds to the isolated C1 domain of Munc13-1 and the full-length Munc13-1 protein (Kis: 8.07 nM and 0.45 nM). | |||
TN4747 |
(-)-beta-Peltatin
|
Others | Others |
(-)-beta-Peltatin has antimitotic, and antineoplastic activities. | |||
T32774 |
Linustatin
|
||
Linustatin is a cyanogenic glucoside isolated from linseed oil. | |||
T83863 |
Fluostatin A sodium
|
||
Fluostatin A是一种最初从链霉菌中分离出的荧光酮类化合物。它对二肽基肽酶3(DPP-3)的选择性抑制作用优于对DPP-1、DPP-2和DPP-4的抑制作用(IC50s分别为0.44, >100, >100, 和 >100 µg/ml)。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-00733 |
SPINK1 Protein, Human, Recombinant (His)
PSTI,Pancreatic Secretory Trypsin Inhibitor,TATI,Se... |
Human | HEK293 Cells |
Serine Protease Inhibitor Kazal-Type 1 (SPINK1) is a trypsin inhibitor that prevent the trypsin-catalyzed premature activation of zymogens within the pancreas. Defects in SPINK1 are a cause of pancreatitis (PCTT). A disease characterized by the presence of calculi in pancreatic ducts. It causes severe abdominal pain attacks. Defects in SPINK1 are the cause of susceptibility to tropical calcific pancreatitis (TCP). Recombinant SPINK1 protein (rSPINK1) stimulated cell proliferation in benign RWPE ... | |||
TMPY-00767 |
Cystatin C Protein, Human, Recombinant (His)
ARMD11,cystatin C |
Human | HEK293 Cells |
Cystatin C Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 14.8 kDa and the accession number is A0A0K0K1J1. | |||
TMPJ-01467 |
Oncostatin M/OSM Protein, Human, Recombinant (E. coli, His)
Oncostatin-M,OSM |
Human | E. coli |
Oncostatin M (OSM) is a glycoprotein belonging to the interleukin-6 family of cytokines that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. OSM encodes a growth regulator, which Inhibits the proliferation of a number of tumor cell lines. It stimulates proliferation of AIDS-KS cells. OSM regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. OSM is considered as a pleiotropic cytokine that initiates its biological ac... | |||
TMPY-01368 |
Cystatin F/CST7 Protein, Human, Recombinant (His)
CMAP,cystatin F (leukocystatin) |
Human | HEK293 Cells |
Cystatin F/CST7 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 16.1 kDa and the accession number is O76096. | |||
TMPY-00770 |
Cystatin F/CST7 Protein, Human, Recombinant
cystatin F (leukocystatin),CMAP |
Human | HEK293 Cells |
Cystatin F/CST7 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 15.2 kDa and the accession number is O76096. | |||
TMPY-00640 |
Cystatin C Protein, Human, Recombinant
ARMD11,cystatin C |
Human | HEK293 Cells |
Cystatin C Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 13.3 kDa and the accession number is AAA52164.1. | |||
TMPY-02070 |
Cystatin SN Protein, Human, Recombinant (His)
CST1,cystatin SN |
Human | HEK293 Cells |
Cystatin-SN, also known as Cystain-SA-I, Cystatin-1, Salivary cystatin-SA-1 and CST1, is a secreted protein which belongs to thecystatin family. The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. Cystatin-SN / CST1 is expressed in submandibular and sublingual saliva but not in parotid saliva (at protein level). Cy... | |||
TMPJ-00948 |
Endostatin Protein, Mouse, Recombinant (His)
antiangiogenic agent,type XVIII,collagen α-1(XVIII)chain,col... |
Mouse | HEK293 Cells |
Endostatin, an endogenous non‑glycosylated inhibitor of endothelial cell proliferation and angiogenesis. It is produced and/or trimmed by metalloproteinases such as MMP‑2 and MMP‑9, and cathepsins S, B and L. The N‑terminal ~27 aa of Endostatin appear to contain the majority of its activity. This region contains zinc binding sites that are thought to be critical for its anti‑endothelial and anti‑tumor effects, as well as multiple cleavage sites that, when used, can modify its activity. Mouse End... | |||
TMPH-03345 |
Oncostatin M/OSM Protein, Rat, Recombinant (His)
|
Rat | HEK293 Cells |
Growth regulator. Inhibits the proliferation of a number of tumor cell lines. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses only type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration. Oncostatin M/OSM Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with N-10xHis tag. The predicted molecular weight is 24.2 kDa and ... | |||
TMPY-00283 |
Oncostatin M/OSM Protein, Human, Recombinant
oncostatin M |
Human | HEK293 Cells |
Oncostatin M/OSM Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 22.16 kDa and the accession number is P13725. | |||
TMPY-01644 |
Cystatin S Protein, Human, Recombinant (His)
MGC71923,cystatin S,CST4 |
Human | HEK293 Cells |
Cystatin-S, also known as Cystatin-4, Salivary acidic protein 1, Cystatin-SA-III and CST4, is a secreted protein which belongs to thecystatin family. Cystatin-4 / CST4 is expressed in submandibular and sublingual saliva but not in parotid saliva (at protein level). It is also expressed in saliva, tears, urine and seminal fluid. The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while oth... | |||
TMPY-02056 |
Cystatin C Protein, Rat, Recombinant (His)
cystatin C |
Rat | HEK293 Cells |
Cystatin C Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 14.7 kDa and the accession number is P14841-1. | |||
TMPK-00576 |
Oncostatin M/OSM Protein, Canine, Recombinant (His)
Oncostatin M,OSM,MGC20461 |
Canine | HEK293 Cells |
Oncostatin M/OSM Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 21.65 kDa and the accession number is A0A8I3Q5M1. | |||
TMPY-01370 |
Cystatin C Protein, Mouse, Recombinant (His)
cystatin C,CysC |
Mouse | HEK293 Cells |
Cystatin C Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15 kDa and the accession number is P21460. | |||
TMPY-02364 |
Oncostatin M/OSM Protein, Human, Recombinant (His)
oncostatin M |
Human | HEK293 Cells |
Oncostatin M/OSM Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 23.6 kDa and the accession number is P13725. | |||
TMPH-00213 |
Disintegrin batroxostatin Protein, Bothrops atrox, Recombinant (His & Myc)
Platelet aggregation activation inhibitor,Disintegrin colomb... |
Bothrops atrox | E. coli |
Inhibits fibrinogen interaction with platelets. Acts by binding to the glycoprotein IIb-IIIa receptor (ITGA2B/ITGB3) on the platelet surface and inhibits aggregation induced by ADP, thrombin, platelet-activating factor and collagen. Also inhibits T24 and SK-Mel-28 cell adhesion to fibronectin with IC(50) of 4.4 uM and 33 nM, respectively. Disintegrin batroxostatin Protein, Bothrops atrox, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted... | |||
TMPY-02077 |
Cystatin A Protein, Human, Recombinant (His)
STFA,STF1,cystatin A,AREI |
Human | E. coli |
Cystatin-A, also known as Cystatin-AS, Stefin-A and CSTA, is a cytoplasm protein which belongs to thecystatin family. Cystatin-A / CSTA is a cysteine proteinase inhibitor with a molecular mass of 11 kDa, and is located mainly in the keratohyaline granules of the stratum granulosum and the cornified envelope of the stratum corneum in the epidermis. The cystatins are a family of cysteine protease inhibitors with homology to chicken cystatin. Cystatins are physiological inhibitors of cystein... | |||
TMPY-02212 |
Follistatin Protein, Human, Recombinant (hFc)
follistatin,FS |
Human | HEK293 Cells |
Follistatin Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 61.7 kDa and the accession number is NP_037541.1. | |||
TMPY-02672 |
Prostatic Acid Phosphatase Protein, Mouse, Recombinant (His)
5'-NT,9.104100899-104272570.1,Ppal,A030005E02Rik,PAP,Lap,aci... |
Mouse | HEK293 Cells |
Prostatic Acid Phosphatase Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42 kDa and the accession number is Q8CE08-1. | |||
TMPY-04062 |
Oncostatin M/OSM Protein, Mouse, Recombinant
oncostatin M,OncoM |
Mouse | E. coli |
Oncostatin M/OSM Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 20.7 kDa and the accession number is P53347. | |||
TMPY-02359 |
Follistatin Protein, Mouse, Recombinant (His)
FS,follistatin,AL033346 |
Mouse | HEK293 Cells |
Follistatin Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36.1 kDa and the accession number is P47931. | |||
TMPY-02090 |
Cystatin B Protein, Human, Recombinant (His)
PME,EPM1A,STFB,ULD,cystatin B (stefin B),EPM1,CST6 |
Human | E. coli |
Cystatin-B, also known as CPI-B, Liver thiol proteinase inhibitor, Stefin-B, CSTB and CST6, is a cytoplasm and nucleus protein which belongs to thecystatin family. Cystatin-B / CSTB is an intracellular thiol proteinase inhibitor. Tightly binding reversible inhibitor of cathepsins L, H and B. Cystatin-B / CSTB is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. Cystatin-B / CSTB is also thought to play a role in protecting against the prot... | |||
TMPH-02910 |
Somatostatin Protein, Mouse, Recombinant (His & KSI)
|
Mouse | E. coli |
Somatostatin Protein, Mouse, Recombinant (His & KSI) is expressed in E. coli expression system with N-6xHis-KSI tag. The predicted molecular weight is 18.5 kDa and the accession number is P60041. | |||
TMPK-00146 |
Oncostatin M/OSM Protein, Human, Recombinant (His & Avi), Biotinylated
OSM,MGC20461,Oncostatin M |
Human | HEK293 Cells |
Oncostatin M/OSM Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 25.1 kDa and the accession number is P13725. | |||
TMPH-02445 |
Oncostatin M/OSM Protein, Rhesus macaque, Recombinant (His)
|
Rhesus | Baculovirus Insect Cells |
Oncostatin M/OSM Protein, Rhesus macaque, Recombinant (His) is expressed in Baculovirus insect cells with N-10xHis tag. The predicted molecular weight is 28.8 kDa and the accession number is F7GF43. | |||
TMPY-02256 |
Follistatin Protein, Human, Recombinant (His)
FS,follistatin |
Human | HEK293 Cells |
Follistatin Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 33 kDa and the accession number is P19883-2. | |||
TMPY-00769 |
Cystatin F/CST7 Protein, Human, Recombinant (hFc)
cystatin F (leukocystatin),CMAP |
Human | HEK293 Cells |
Cystatin F/CST7 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 41.3 kDa and the accession number is O76096. | |||
TMPY-02856 |
Cystatin F/CST7 Protein, Mouse, Recombinant (hFc)
Cmap,cystatin F (leukocystatin) |
Mouse | HEK293 Cells |
Cystatin F/CST7 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 41.4 kDa and the accession number is O89098. | |||
TMPJ-01174 |
Cystatin B Protein, Mouse, Recombinant (His)
PME,CST6cystatin B (liver thiol proteinase inhibito... |
Mouse | E. coli |
Cystatin B, also called stefin B or liver thiol proteinase inhibitor, is a member of family 1 of the cystatin superfamily. Like Cystatin A, it is an intracellular inhibitor regulating the activities of cysteine proteases of the papain family such as cathepsins B, H and L. Defects in Cystatin-B / CSTB are the cause of progressive myoclonic epilepsy type 1 (EPM1) which is an autosomal recessive disorder characterized by severe, stimulus-sensitive myoclonus and tonic-clonic seizures. | |||
TMPY-02155 |
Prostatic Acid Phosphatase Protein, Human, Recombinant (His)
5'-NT,acid phosphatase, prostate,PAP,ACP-3,ACP3 |
Human | HEK293 Cells |
Prostatic Acid Phosphatase Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42 kDa and the accession number is P15309-2. | |||
TMPY-01645 |
Cystatin SA Protein, Human, Recombinant (His)
CST2,MGC71924,cystatin SA |
Human | HEK293 Cells |
Cystatin-SA, also known as Cystatin-2, Cystatin-S5 and CST2, is a secreted protein which belongs to thecystatin family. Cystatin-2 / CST2 is expressed in submandibular and sublingual saliva but not in parotid saliva (at protein level). It is also expressed in submandibular gland and parotid gland. The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never ... | |||
TMPY-00729 |
Cystatin D Protein, Human, Recombinant (His)
CST5,MGC71922,cystatin D |
Human | HEK293 Cells |
Cystatins are natural inhibitors of papain-like (family C1) and legumain-related (family C13) cysteine peptidases. The mammalian cystatin superfamily members are of three major types, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. As a member of type 2 cystatin, cystatin D is a single-domain protein and also has cysteine residues that form disulfide bridges. In contrast with the wider distribution of all the other family 2 cystatins, cystatin D is tissue-restricte... | |||
TMPK-00145 |
Oncostatin M/OSM Protein, Human, Recombinant (His & Avi)
Oncostatin M,OSM,MGC20461 |
Human | HEK293 Cells |
Oncostatin M/OSM Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 25.1 kDa and the accession number is P13725. | |||
TMPJ-00227 |
Follistatin 288 Protein, Human, Recombinant (His)
FSActivin-binding protein,Follistatin,follistat... |
Human | HEK293 Cells |
Follistatin 288 is a secreted glycoprotein that was first identified as a follicle-stimulating hormone inhibiting substance in ovarian follicular fluid . Human follistatin 288 cDNA encodes a 317 amino acid (aa) protein with a 29 aa signal sequence, and a 288 aa mature region. Follistatin shows the highest affinity for activins due to its extended configuration. Genetic deletion of follistatin in mice, or expression of only the Follistatin form, is perinatally lethal due to defects of lung, skin ... | |||
TMPY-03368 |
Follistatin Protein, Mouse, Recombinant (hFc)
follistatin,FS,AL033346 |
Mouse | CHO Cells |
Follistatin Protein, Mouse, Recombinant (hFc) is expressed in CHO mammalian cells with hFc tag. The predicted molecular weight is 58.4 kDa and the accession number is P47931. | |||
TMPY-02627 |
Oncostatin M/OSM Protein, Mouse, Recombinant (His)
OncoM,oncostatin M |
Mouse | HEK293 Cells |
Oncostatin M/OSM Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 22 kDa and the accession number is P53347. |