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Search Results for " dna polymerase "

134

抑制剂 & 化合物

23

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T80644	DNA polymerase-IN-1	Antiviral; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Immunology/Inflammation
	DNA polymerase-IN-1 作为DNA聚合酶抑制剂，展现出对肿瘤细胞的抗增殖活性，其半抑制浓度（IC50）为20.7 μM。DNA polymerase-IN-1 抑制 Taq DNA 聚合酶，IC 值低于 250μM。DNA polymerase-IN-1 通过RT-PCR检测在体外显示出抗逆转录病毒活性，可用于研究氧化损伤和结直肠癌。
T1767	BMH-21 BMH21	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	BMH-21 是一种小分子 DNA 嵌入剂，可结合核糖体 DNA 并抑制 RNA 聚合酶 I (Pol I) 转录，具有抗癌活性。
T9165	AZD5305	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	AZD5305 是一种强效、选择性和口服活性 PARP 抑制剂，可用于肿瘤异体移植模型研究。
T0220	Foscarnet sodium Phosphonoformate,膦甲酸钠	Virus Protease; Reverse Transcriptase; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Foscarnet sodium (Phosphonoformate) 是一种病毒 DNA 聚合酶活性抑制剂，可逆地抑制病毒复制。它是一种用于治疗巨细胞病毒性视网膜炎的抗病毒剂。
T79922	Taq DNA polymerase	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Taq DNA 聚合酶是一种在PCR过程中广泛使用的耐热性酶，由Thermus aquaticus细菌产生，其功能是在高温下合成DNA链。
T8972	FIT-039	Others; DNA/RNA Synthesis; CDK; HSV	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Others
	FIT-039 是一种选择性和 ATP 竞争性的口服活性 CDK9 抑制剂，对CKD9/cyclin T1的IC50为 5.8 μM。它抑制HSV-1(IC50为 0.69 μM)，HSV-2，人腺病毒和人CMV 的复制。它可抑制耐药性HSV 和其他 DNA 病毒，是有前途的抗病毒药物。
T5399	GeA-69	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	GeA-69 是一种选择性变构 PARP14 大结构域 2 (MD2) 抑制剂，Kd 值为 2.1 µM。
T82536	DNA polymerase-IN-4
	DNA polymerase-IN-4 (Compd 5c)，香豆素衍生物，显示出抗逆转录病毒活性，IC50为134.22 μM。
T79308	DNA polymerase-IN-3	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	DNA polymerase-IN-3 (Compd 5b) 为香豆素衍生物，对 Taq DNA聚合酶具有抑制活性，适用于增值性疾病研究。
T79307	DNA polymerase-IN-2	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	DNA polymerase-IN-2 (Compd 3c)为香豆素衍生物，对Taq DNA聚合酶具有抑制作用，IC50为48.25 μM，适用于增殖性疾病研究。
T10104	3,4-Dihydroxybenzylamine hydrobromide NSC 263475 hydrobromide,3,4-二羟基苄胺·氢溴酸	Others; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Others
	3,4-Dihydroxybenzylamine hydrobromide (NSC-263475 hydrobromide) 抑制黑色素瘤细胞中的 DNA 聚合酶活性，并在具有不同程度酪氨酸酶活性的黑色素瘤细胞系中显示出生长抑制活性。
T1454	Acyclovir Aciclovir,Acycloguanosine,阿昔洛韦	Apoptosis; DNA/RNA Synthesis; Antibacterial; Antibiotic; HSV	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Acyclovir (Aciclovir) 是鸟嘌呤类似物和具有口服活性的抗病毒剂。它对HSV-1(IC50为 0.85 μM)，HSV-2(IC50为 0.86 μM) 和水痘带状疱疹病毒有活性。
T9497	Niraparib tosylate monohyrate	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Niraparib tosylate monohyrate 也称为 MK-4827，是一种聚 (ADP-核糖) 聚合酶 (PARP) 抑制剂，具有潜在的抗肿瘤活性。 MK4827 抑制 PARP 活性，增强 DNA 链断裂的积累，促进基因组不稳定性和细胞凋亡。 PARP 蛋白家族通过碱基切除修复 (BER) 途径检测和修复单链 DNA 断裂。
T6446	Clevudine L-FMAU,克拉夫定,Levovir	HBV; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Clevudine (Levovir) 是一种非自然 L-构型的核苷类似物，是一种与聚合酶结合的非竞争性抑制剂，具有较强的抗 HBV 活性，半衰期长，毒性低的特点。
T6912	NU1025 NSC 696807	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	NU1025 (NSC-696807) 是一种PARP 的有效抑制剂，IC50为 400 nM，Ki 为 48 nM。它可增强电离辐射和抗癌药物的细胞毒性，有抗癌和神经保护的作用。
T3231	Niraparib 尼拉帕尼,MK-4827	Apoptosis; Others; PARP	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Others
	Niraparib (MK-4827) 是一种 PARP 抑制剂，可以抑制 PARP1 和 PARP2 (IC50=3.8/2.1 nM)，具有选择性。Niraparib 具有抗肿瘤活性，可以抑制 DNA 损伤修复、诱导细胞凋亡。
T3489	Dasabuvir ABT-333,达塞布韦	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	Dasabuvir (ABT-333) 是丙型肝炎病毒非结构蛋白 5B 的非核苷抑制剂，是一种 RNA 依赖性 RNA 聚合酶，具有抗 HCV 的潜在活性。
T9024	OUL35 NSC39047	Others; PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair; Others
	OUL35 (NSC-39047) 是一种选择性 PARP-10 抑制剂和小分子 ARTD10 抑制剂，其 IC50值为 329 nM。
T6729	Lomibuvir VX-222,VCH-222	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	Lomibuvir (VCH-222) (VX-222) 是丙型肝炎病毒 NS5B 聚合酶的一种非核苷变构抑制剂，Kd 值为 17 nM，已证明具有临床疗效。Lomibuvir 抑制 1b/Con1 型 HCV 亚基因组复制子，EC50为 5.2 nM。Lomibuvir 优先抑制延长的 RNA 合成，而非从头合成的 RNA。
T0863	Idoxuridine IDU,碘苷,SKF 14287,5-Iodo-2′-deoxyuridine,NSC 39661,5-IUdR,Dendrid	Antifection; HSV	Microbiology/Virology
	Idoxuridine (Dendrid) 是一种抑制病毒 DNA 合成的脱氧尿苷类似物，用作抗病毒剂。
T0964	Floxuridine 氟尿苷,5-Fluorouracil 2'-deoxyriboside,FUDR,Deoxyfluorouridine,NSC 27640	Apoptosis; Nucleoside Antimetabolite/Analog; Others; DNA/RNA Synthesis; Antibacterial; HSV	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Others
	Floxuridine (FUDR) 是一种嘧啶类似物，也是一种抗肿瘤代谢物。它抑制胸苷酸合成酶，导致 DNA 合成中断和细胞毒性。它是一种可诱导细胞凋亡的金黄色葡萄球菌感染抑制剂，具有抗HSV 和CMV 病毒的作用。
T4686	Simeprevir TMC435,西咪匹韦,TMC-435350,Olysio	HCV Protease; SARS-CoV	Microbiology/Virology; Proteases/Proteasome
	Simeprevir (TMC435) 是一种有效的 HCV NS3/4A 蛋白酶抑制剂，抑制 HCV 复制，EC50 为 7.8 nM。它也是 SARS-CoV-2 3CLpro 抑制剂。
T3353	Niraparib hydrochloride 尼拉帕利盐酸盐,MK-4827 hydrochloride,MK-4827 (hydrochloride)	Apoptosis; Others; PARP	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Others
	Niraparib hydrochloride (MK-4827 hydrochloride) 是一种具有口服活性的PARP1和PARP2抑制剂，IC50值分别为 3.8 nM 和 2.1 nM。它抑制 DNA 损伤修复，诱导凋亡并具有抗肿瘤活性。
T0688	Ganciclovir BW 759,更昔洛韦,RS-21592,2'-Nor-2'-deoxyguanosine	Nucleoside Antimetabolite/Analog; Others; Antibiotic; Antifection; HSV	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Others
	Ganciclovir (2'-Nor-2'-deoxyguanosine) 是核苷类似物和口服抗病毒药物，对CMV 具有抗病毒活性。它用于治疗与艾滋病相关的巨细胞病毒感染的并发症。
T8842	IMT1B 3-Piperidinecarboxylic acid, 1-[(2R)-2-[[4-(2-chloro-4-fluorophenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-1-oxopropyl]-, (3S)-,LDC203974	Others; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Others
	IMT1B (LDC203974) 是一种特异性的、具有口服活性的、非竞争性的线粒体 RNA 聚合酶 (POLRMT) 别构抑制剂，能够抑制线粒体 DNA (mtDNA) 的表达，具有抗肿瘤活性。
T8841	IMT1 Propanamide, N,N-dimethyl-2-[[4-(2-methylphenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-,LDC195943(IMT1)	Others; DNA/RNA Synthesis; Mitochondrial Metabolism	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Others
	IMT1 (Propanamide, N,N-dimethyl-2-[[4-(2-methylphenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-) 是一种非竞争特异性人类线粒体 RNA 聚合酶(POLRMT) 抑制剂，可引起 POLRMT 的构象变化，以剂量依赖性方式阻断底物结合和转录。它可降低脱氧核苷三磷酸水平和柠檬酸循环中间体，导致细胞氨基酸水平显著消耗，有用于线粒体转录等相关疾病的研究潜力。
T6892	Niraparib tosylate 尼拉帕利,MK-4827 (tosylate),MK 4827 tosylate,Niraparib (MK-4827) tosylate,尼拉帕尼对苯甲磺酸盐	Apoptosis; PARP	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair
	Niraparib tosylate (MK-4827(tosylate)) 是一种高效的，具有生物口服利用度的PARP1和PARP2抑制剂，IC50分别为 3.8 和 2.1 nM。它抑制 DNA 损伤修复，诱导凋亡并具有抗肿瘤活性。
T22337	Ganciclovir sodium RS-21592 sodium,Cytovene IV sodium,2'-Nor-2'-deoxyguanosine sodium,BW 759 sodium,更昔洛韦钠	Nucleoside Antimetabolite/Analog; Others; Antifection; HSV	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Others
	Ganciclovir sodium (Cytovene IV sodium) 是核苷类似物和口服抗病毒药物，具有抗病毒活性，尤其是针对巨细胞病毒和单纯疱疹病毒 1 型。
T6501	Fludarabine Phosphate NSC 312887 Phosphate,fludara Phosphate,F-ara-A (NSC 312887) Phosphate,F-ara-AMP,磷酸氟达拉滨	Apoptosis; Nucleoside Antimetabolite/Analog; DNA/RNA Synthesis	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Fludarabine Phosphate (NSC 312887 Phosphate) 是一种腺苷和脱氧腺苷类似物，与 dATP 竞争，并入到 DNA，可以抑制 DNA 聚合酶 α、核糖核苷酸还原酶和 DNA 引发酶，从而中断 DNA 合成并抑制肿瘤细胞生长。
T1646	Famciclovir 泛昔洛韦,BRL 42810	DNA/RNA Synthesis; HSV	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Famciclovir (BRL 42810) 是一种单纯疱疹病毒核苷类似物 DNA 聚合酶抑制剂。
T26726	AzddMeC Az-Dcme,Azidodideoxymethylcytidine,CS-92
	Az-Dcme, a RNA-directed DNA polymerase inhibitor, is used potentially for the treatment of HIV infection.
T40236	ART812 ART812	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	ART812 is an orally active inhibitor of DNA polymerase Polθ, possessing an IC50 value of 7.6 nM. Additionally, ART812 exhibits a cell-based microhomology-mediated end joining (MMEJ) IC50 value of 240 nM.
T1643	Penciclovir 喷昔洛韦,BRL 39123,VSA 671	HCV Protease; Antifection; HSV	Microbiology/Virology; Proteases/Proteasome
	Penciclovir (BRL 39123) 是一种疱疹病毒核苷类似物 DNA 聚合酶抑制剂。它作用于HSV1 和 2，IC50分别为 0.04-1.8 μg/mL 和 0.06-4.4 μg/mL。
T1416	Zidovudine Azidothymidine,NSC 602670,ZDV,齐多夫定,AZT,叠氮胸苷	HIV Protease; Reverse Transcriptase; Telomerase; CRISPR/Cas9	DNA Damage/DNA Repair; Microbiology/Virology; Proteases/Proteasome
	Zidovudine (ZDV) 是一种核苷逆转录酶抑制剂，有潜力研究 HIV 感染。
T7655	Fialuridine DRG-0098,FIAU,非阿尿苷	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Fialuridine (DRG-0098) 是一种 DNA 导向的 DNA 聚合酶抑制剂，可能用于治疗 HBV 感染，在体外和体内对乙型肝炎病毒具有有效的活性。
T9275	ART558	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	ART558 是一种高效的、选择性的、变构 DNA 聚合酶活性的 Polθ 抑制剂，IC50为7.9 nM。ART558 可用于癌症研究。
T1533	Valganciclovir hydrochloride Valganciclovir HCl,Valcyt,缬更昔洛韦盐酸盐,Valcyte	Others; Antiviral	Immunology/Inflammation; Others
	Valganciclovir hydrochloride (Valganciclovir HCl) 是 ganciclovir 的原药，具有抗巨细胞病毒活性，可抑制病毒 DNA 聚合酶和病毒复制。
T35719	T2AA T2AA,4-[4-[(2S)-2-amino-3-hydroxypropyl]-2,6-diiodophenoxy]phenol,ZINC95605533	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	T2AA (4-[4-[(2S)-2-amino-3-hydroxypropyl]-2,6-diiodophenoxy]phenol) 是一种增殖细胞核抗原 (PCNA) 抑制剂，对 PCNA/PIP-box 肽相互作用的 IC50 为 1 μM。 T2AA 通过停止 DNA 复制叉和抑制 PCNA 与 DNA 聚合酶 δ 的相互作用来引起 DNA 复制压力并抑制癌细胞生长。
T36688	Deoxyguanosine triphosphate trisodium salt Deoxyguanosine 5-triphosphate,2'-Deoxyguanosine-5'-triphosphate trisodium salt,dGTP trisodium salt	Nucleoside Antimetabolite/Analog	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Deoxyguanosine triphosphate trisodium salt (2'-Deoxyguanosine-5'-triphosphate trisodium salt) 是细胞中用于 DNA 合成的核苷酸前体，可用于逆转录聚合酶链反应 (RT-PCR) 中以进行 DNA 扩增。
T1272L	Cytarabine hydrochloride Ara-C hydrochloride,Cytosine Arabinoside hydrochloride	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Cytarabine hydrochloride (Ara-C hydrochloride) 是一种核苷类似物，可导致 S 期细胞周期停滞并抑制DNA 聚合酶。Cytarabine 抑制DNA 合成，IC50为 16 nM。Cytarabine hydrochloride 对HSV 具有抗病毒作用。
T77520	AOH1996	Apoptosis; DNA/RNA Synthesis	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	AOH1996 是一种具有口服活性的复制体组分 PCNA (增殖细胞核抗原) 配体，靶向转录-复制冲突 (TRC)。AOH1996 可干扰 PCNA 与其结合蛋白的相互作用，导致 DNA 复制应激，诱导细胞凋亡 (apoptosis)。AOH1996 通过稳定 PCNA 和 RNA 聚合酶 II 的相互作用从而导致蛋白酶体依赖的 rpb1 降解和致命的 DNA 损伤。AOH1996 与 DNA 损伤剂具有协同作用，可抑制肿瘤细胞生长。
T0297	Clofarabine Clofarex,氯法拉滨,克罗拉滨,Evoltra,Clolar	Apoptosis; Nucleoside Antimetabolite/Analog; DNA/RNA Synthesis; Autophagy	Apoptosis; Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Clofarabine (Clofarex) 是一种核糖核苷酸还原酶抑制剂，IC50值为65 nM。它是核苷类似物，可用于癌症研究。
T1501	Rifabutin LM-427,Ansamycin,利福布汀,利福布丁	HSP; DNA/RNA Synthesis; Antibacterial; Antibiotic	Cell Cycle/Checkpoint; Cytoskeletal Signaling; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology
	Rifabutin (LM-427) 是半合成的安莎霉素抗生素，抑制 DNA 依赖性 RNA 聚合酶，有抗分枝杆菌作用。
T60187	RP-6685	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	RP-6685, a highly potent and selective inhibitor of DNA polymerase theta (Polθ), manifests remarkable oral activity. With an IC 50 value of 5.8 nM in the PicoGreen assay, RP-6685 effectively hinders the enzymatic activity of Polθ. In addition, it demonstrates significant antitumor efficacy as observed in a mouse tumor xenograft model [1].
T28918	Talviraline Bay 10-8979,HBY 097,Bay10-8979,Bay-108979,Bay108979,Bay 108979,Bay-10-8979	HIV Protease; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Proteases/Proteasome
	Talviraline (Bay 10-8979) 是一种 RNA 引导的 DNA 聚合酶抑制剂。Talviraline 对多种人类细胞系以及新鲜人类外周血淋巴细胞和巨噬细胞中的 HIV-1 诱导的细胞杀伤和 HIV-1 复制具有很强的抑制作用。
T8736	Cidofovir dihydrate HPMPC,(S)-HPMPC,GS 0504,西多福韦二水合物	Others	Others
	Cidofovir dihydrate (HPMPC) 是注射型巨细胞病毒 DNA 聚合酶抑制剂，通过选择性抑制病毒 DNA 聚合酶来抑制 CMV 复制，从而阻止病毒复制和转录。
T1154	Rifaximin	DNA/RNA Synthesis; Antibacterial; Antibiotic	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Rifaximin 是一种胃肠道选择性抗生素，与细菌 DNA 依赖性 RNA 聚合酶的 β 亚基结合，抑制细菌 RNA 合成。与革兰氏阴性菌（MIC：8-50 毫克/毫升）相比，它对革兰氏阳性菌株（MIC：0.03-5 毫克/毫升）的敏感性更高。
T67509	Cholesteryl Hemisuccinate Cholesterol hydrogen succinate	Apoptosis; DNA/RNA Synthesis; Topoisomerase	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Cholesteryl Hemisuccinate (Cholesterol hydrogen succinate) 是一种经常使用在极性溶液中具有高溶解度的胆固醇类似物，具有保肝、抗癌和抑制肿瘤生长的作用。Cholesteryl Hemisuccinate 抑制对乙酰氨基酚的肝毒性，并防止 AAP 诱导的肝细胞凋亡和坏死。Cholesteryl Hemisuccinate 抑制 DNA 聚合酶和 DNA 拓扑异构酶，从而抑制 DNA 复制和修复以及细胞分裂。
T14313	Apricitabine AVX754,SPD754	HIV Protease; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Proteases/Proteasome
	Apricitabine (SPD754) 是一种具有高选择性和口服活性的HIV-1逆转录酶抑制剂(Ki=0.08μM)，是2′-脱氧-3′-氧-4′-硫代胞苷(dOTC)的(-)对映体。 Apricitabine 对DNA 聚合酶α、β和γ具有抑制作用，Ki 值分别为300μM、12μM 和112.25μM。Apricitabine 在抗逆转录病毒HIV 感染者中显示出良好的抗逆转录病毒治疗效果，具有良好的耐受性和较低的选择性抗性。
T3157	COH29 RNR Inhibitor COH29	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	COH29 (RNR Inhibitor COH29) 是一种口服可用的芳香族取代噻唑，是人类核糖核苷酸还原酶 (RNR) 的抑制剂，具有潜在的抗肿瘤活性。它抑制核糖核苷酸还原酶的IC50为 16 μM。

化合物

DNA polymerase-IN-1

Cat.No: T80644

Target: Antiviral, DNA/RNA Synthesis

Cat.No: T1767

Synonym: BMH21

Target: DNA/RNA Synthesis

Cat.No: T9165

Target: PARP

Foscarnet sodium

Cat.No: T0220

Synonym: Phosphonoformate,膦甲酸钠

Target: Virus Protease, Reverse Transcriptase, DNA/RNA Synthesis

Taq DNA polymerase

Cat.No: T79922

Target: DNA/RNA Synthesis

Cat.No: T8972

Target: Others, DNA/RNA Synthesis, CDK, HSV

Cat.No: T5399

Target: PARP

DNA polymerase-IN-4

Cat.No: T82536

DNA polymerase-IN-3

Cat.No: T79308

Target: DNA/RNA Synthesis

DNA polymerase-IN-2

Cat.No: T79307

Target: DNA/RNA Synthesis

3,4-Dihydroxybenzylamine hydrobromide

Cat.No: T10104

Synonym: NSC 263475 hydrobromide,3,4-二羟基苄胺·氢溴酸

Target: Others, DNA/RNA Synthesis

Cat.No: T1454

Synonym: Aciclovir,Acycloguanosine,阿昔洛韦

Target: Apoptosis, DNA/RNA Synthesis, Antibacterial, Antibiotic, HSV

Niraparib tosylate monohyrate

Cat.No: T9497

Target: PARP

Cat.No: T6446

Synonym: L-FMAU,克拉夫定,Levovir

Target: HBV, DNA/RNA Synthesis

Cat.No: T6912

Synonym: NSC 696807

Target: PARP

Cat.No: T3231

Synonym: 尼拉帕尼,MK-4827

Target: Apoptosis, Others, PARP

Cat.No: T3489

Synonym: ABT-333,达塞布韦

Target: HCV Protease

Cat.No: T9024

Synonym: NSC39047

Target: Others, PARP

Cat.No: T6729

Synonym: VX-222,VCH-222

Target: HCV Protease

Cat.No: T0863

Synonym: IDU,碘苷,SKF 14287,5-Iodo-2′-deoxyuridine,NSC 39661,5-IUdR,Dendrid

Target: Antifection, HSV

Cat.No: T0964

Synonym: 氟尿苷,5-Fluorouracil 2'-deoxyriboside,FUDR,Deoxyfluorouridine,NSC 27640

Target: Apoptosis, Nucleoside Antimetabolite/Analog, Others, DNA/RNA Synthesis, Antibacterial, HSV

Cat.No: T4686

Synonym: TMC435,西咪匹韦,TMC-435350,Olysio

Target: HCV Protease, SARS-CoV

Niraparib hydrochloride

Cat.No: T3353

Synonym: 尼拉帕利盐酸盐,MK-4827 hydrochloride,MK-4827 (hydrochloride)

Target: Apoptosis, Others, PARP

Cat.No: T0688

Synonym: BW 759,更昔洛韦,RS-21592,2'-Nor-2'-deoxyguanosine

Target: Nucleoside Antimetabolite/Analog, Others, Antibiotic, Antifection, HSV

Cat.No: T8842

Synonym: 3-Piperidinecarboxylic acid, 1-[(2R)-2-[[4-(2-chloro-4-fluorophenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-1-oxopropyl]-, (3S)-,LDC203974

Target: Others, DNA/RNA Synthesis

Cat.No: T8841

Synonym: Propanamide, N,N-dimethyl-2-[[4-(2-methylphenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-,LDC195943(IMT1)

Target: Others, DNA/RNA Synthesis, Mitochondrial Metabolism

Niraparib tosylate

Cat.No: T6892

Synonym: 尼拉帕利,MK-4827 (tosylate),MK 4827 tosylate,Niraparib (MK-4827) tosylate,尼拉帕尼对苯甲磺酸盐

Target: Apoptosis, PARP

Ganciclovir sodium

Cat.No: T22337

Synonym: RS-21592 sodium,Cytovene IV sodium,2'-Nor-2'-deoxyguanosine sodium,BW 759 sodium,更昔洛韦钠

Target: Nucleoside Antimetabolite/Analog, Others, Antifection, HSV

Fludarabine Phosphate

Cat.No: T6501

Synonym: NSC 312887 Phosphate,fludara Phosphate,F-ara-A (NSC 312887) Phosphate,F-ara-AMP,磷酸氟达拉滨

Target: Apoptosis, Nucleoside Antimetabolite/Analog, DNA/RNA Synthesis

Cat.No: T1646

Synonym: 泛昔洛韦,BRL 42810

Target: DNA/RNA Synthesis, HSV

Cat.No: T26726

Synonym: Az-Dcme,Azidodideoxymethylcytidine,CS-92

Cat.No: T40236

Synonym: ART812

Target: DNA/RNA Synthesis

Cat.No: T1643

Synonym: 喷昔洛韦,BRL 39123,VSA 671

Target: HCV Protease, Antifection, HSV

Cat.No: T1416

Synonym: Azidothymidine,NSC 602670,ZDV,齐多夫定,AZT,叠氮胸苷

Target: HIV Protease, Reverse Transcriptase, Telomerase, CRISPR/Cas9

Cat.No: T7655

Synonym: DRG-0098,FIAU,非阿尿苷

Target: DNA/RNA Synthesis

Cat.No: T9275

Target: DNA/RNA Synthesis

Valganciclovir hydrochloride

Cat.No: T1533

Synonym: Valganciclovir HCl,Valcyt,缬更昔洛韦盐酸盐,Valcyte

Target: Others, Antiviral

Cat.No: T35719

Synonym: T2AA,4-[4-[(2S)-2-amino-3-hydroxypropyl]-2,6-diiodophenoxy]phenol,ZINC95605533

Target: DNA/RNA Synthesis

Deoxyguanosine triphosphate trisodium salt

Cat.No: T36688

Synonym: Deoxyguanosine 5-triphosphate,2'-Deoxyguanosine-5'-triphosphate trisodium salt,dGTP trisodium salt

Target: Nucleoside Antimetabolite/Analog

Cytarabine hydrochloride

Cat.No: T1272L

Synonym: Ara-C hydrochloride,Cytosine Arabinoside hydrochloride

Target: DNA/RNA Synthesis

Cat.No: T77520

Target: Apoptosis, DNA/RNA Synthesis

Cat.No: T0297

Synonym: Clofarex,氯法拉滨,克罗拉滨,Evoltra,Clolar

Target: Apoptosis, Nucleoside Antimetabolite/Analog, DNA/RNA Synthesis, Autophagy

Cat.No: T1501

Synonym: LM-427,Ansamycin,利福布汀,利福布丁

Target: HSP, DNA/RNA Synthesis, Antibacterial, Antibiotic

Cat.No: T60187

Target: DNA/RNA Synthesis

Cat.No: T28918

Synonym: Bay 10-8979,HBY 097,Bay10-8979,Bay-108979,Bay108979,Bay 108979,Bay-10-8979

Target: HIV Protease, DNA/RNA Synthesis

Cidofovir dihydrate

Cat.No: T8736

Synonym: HPMPC,(S)-HPMPC,GS 0504,西多福韦二水合物

Target: Others

Cat.No: T1154

Target: DNA/RNA Synthesis, Antibacterial, Antibiotic

Cholesteryl Hemisuccinate

Cat.No: T67509

Synonym: Cholesterol hydrogen succinate

Target: Apoptosis, DNA/RNA Synthesis, Topoisomerase

Cat.No: T14313

Synonym: AVX754,SPD754

Target: HIV Protease, DNA/RNA Synthesis

Cat.No: T3157

Synonym: RNR Inhibitor COH29

Target: DNA/RNA Synthesis

Cat. No.	Product Name	Target	Signaling Pathways
T6S0139	Neobavaisoflavone	Apoptosis; DNA/RNA Synthesis	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Neobavaisoflavone 是一种从Psoralea corylifolia 的种子中分离出来的类黄酮。它具有抗炎，抗癌和抗氧化的作用。它在中至高浓度下可抑制 DNA 聚合酶，也可抑制血小板聚集。
T3332	Isosteviol 异甜菊醇,(-)-Isosteviol	IL Receptor; Potassium Channel; TNF; NF-κB; Reactive Oxygen Species; COX; Topoisomerase	Apoptosis; DNA Damage/DNA Repair; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience; NF-κB
	Isosteviol ((-)-Isosteviol) 是一种常见的天然甜味剂，属于四环二萜糖苷，是甜菊糖苷通过酸催化水解产生的。它抑制 DNA 聚合酶和 DNA 拓扑异构酶，具有抗菌、抗癌和抗结核作用。
T6194	Fidaxomicin 非达米星,Tiacumicin B,OPT-80,Clostomicin B1,PAR-101	Apoptosis; DNA/RNA Synthesis; Antibacterial; Antibiotic	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Fidaxomicin (Tiacumicin B) 是一种大环RNA 聚合酶抑制剂，具有窄谱活性。它选择性地根除致病性艰难梭菌，对构成正常健康肠道菌群的多种细菌影响很小。
T3376	Cynaroside 朝蓟糖甙,Luteoloside,Luteolin 7-β-D-Glucopyranoside,Luteolin 7-O-Glucoside,Luteolin 7-O-β-D-glucoside,木犀草苷,Luteolin 7-glucoside	Others; Influenza Virus; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Others
	Cynaroside (Luteolin 7-O-Glucoside) 是一个抗氧化类黄酮。它还是一种流感依赖 RNA 的RNA 聚合酶抑制剂，IC50为 32 nM。
T14304	Aphidicolin	Others	Others
	Aphidicolin is a potent inhibitor of cellular deoxyribonucleic acid synthesis and inhibits the growth of herpes simplex virus[2]. Aphidicolin is an inhibitor of DNA polymerase α and δ, prevents mitotic cell division by interfering with the activity of DNA
T3772	Maslinic acid 2α-Hydroxyoleanoic Acid,山楂酸,2α-Hydroxyoleanolic acid,Crategolic acid	NF-κB; HIV Protease; DNA/RNA Synthesis; Antibacterial	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; NF-κB; Proteases/Proteasome
	Maslinic acid (Crategolic acid) 是一种 DNA 聚合酶 B 抑制剂，抑制 NF-κB p65的 DNA 结合活性并消除 IκB-α磷酸化。
T37635	2'-Deoxyadenosine-5'-triphosphate trisodium dATP trisodium	DNA/RNA Synthesis; Endogenous Metabolite	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism
	2'-Deoxyadenosine-5'-triphosphate trisodium (dATP trisodium) 是一种核苷酸，是 DNA 聚合酶的底物，在细胞中用于 DNA 合成或复制。
T1272	Cytarabine 阿糖胞苷,Ara-C,Cytosine Arabinoside,Cytosine β-D-arabinofuranoside,Arabinocytidine	Apoptosis; Nucleoside Antimetabolite/Analog; DNA/RNA Synthesis; Endogenous Metabolite; Autophagy; HSV	Apoptosis; Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology
	Cytarabine (Ara-C) 是一种核苷类似物，一种 DNA 合成抑制剂 (IC50=16 nM)。Cytarabine 可以抑制 DNA 聚合酶，诱导细胞周期阻滞、细胞自噬和凋亡。Cytarabine 具有抗肿瘤活性。
T9086	Deoxythymidine-5'-triphosphate trisodium dTTP trisodium salt,thymidine 5'-(trisodium hydrogen triphosphate),胸苷-5'-三磷酸三钠盐,脱氧胸苷三磷酸三钠盐,Deoxythymidine-5'-triphosphate (dTTP) trisodium salt	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Deoxythymidine-5'-triphosphate trisodium (Deoxythymidine-5'-triphosphate(dTTP) trisodium salt) 是四种天然脱氧核苷酸之一，用于通过 DNA 聚合酶和逆转录酶生物合成脱氧核糖核酸。
T5003	Rifamycin sodium Rifamycin sodium salt,利福霉素钠	Antibacterial; Antibiotic	Microbiology/Virology
	Rifamycin sodium (Rifamycin sodium salt) salt 是从地中海曲霉或其突变体的发酵中分离出来的一种安沙霉素抗生素家族。它对革兰氏阳性菌和某些革兰氏阴性菌有抗生素活性。
T8347	Rifamycin S	Reactive Oxygen Species; ROS; Antibacterial; Antibiotic	Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB
	Rifamycin S 是一种 DNA 依赖性 RNA 聚合酶抑制剂，是一种醌和一种针对革兰氏阳性细菌的抗生素试剂。它是涉及两个电子的可逆氧化还原系统的氧化形式。它能产生活性氧并抑制微粒体脂质过氧化，可研究肺结核和麻风病。
T1086	Vitamin D2 Calciferol,Ergocalciferol,Ercalciol,维生素D2	DNA/RNA Synthesis; Endogenous Metabolite	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism
	Vitamin D2 (Calciferol) 来源于植物或膳食补充剂，能够用作维生素 D 的补充剂。
T40834	5-Hydroxymethyl-2'-deoxycytidine 5hmdC,2'-脱氧-5-(羟甲基)胞啶	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	5-Hydroxymethyl-2'-deoxycytidine 是 DNA 中 5-methyl-2'-deoxycytidine (5-mdC) 的氧化衍生物，引起DNA损伤反应，染色体畸变，复制叉损伤和细胞活力丧失。5-Hydroxymethyl-2’-deoxycytidine 复制叉不稳定性与染色质上聚（ADP-核糖）聚合酶1（PARP1）的存在有关。
T1591	Ancitabine hydrochloride NSC 145668 HCl,盐酸环胞苷,Cyclocytidine hydrochloride,Cyclo-CMP hydrochloride,Cyclocytidine HCl,Cyclo-C	Others; DNA/RNA Synthesis; Autophagy	Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Others
	Ancitabine hydrochloride (NSC 145668 HCl) 是一种天然的抗白血病药物。
T7961	N4-Benzoyl-2′-deoxycytidine N-苯甲酰-2'-脱氧胞苷	Others	Others
	N4-Benzoyl-2′-deoxycytidine 是天然核苷脱氧胞苷（dC）的合成核苷类似物，是一种DNA 聚合酶的竞争性抑制剂。体外研究表明，它可以抑制病毒、细菌和真核细胞的复制。在动物模型中，它也被证明可以抑制肿瘤细胞的生长。
TN1134	Euscaphic acid	Apoptosis; LDL; PI3K; DNA/RNA Synthesis; NO Synthase; Prostaglandin Receptor	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; GPCR/G Protein; Immunology/Inflammation; Metabolism; PI3K/Akt/mTOR signaling
	Euscaphic acid 是来源于枣的一种三萜，是DNA 聚合酶抑制剂，可诱导细胞凋亡。它抑制小牛 DNA 聚合酶 α 和大鼠 DNA 聚合酶 β 的IC50值分别为 61 和 108 μM。
T1558	Resveratrol 白藜芦醇,trans-Resveratrol,SRT 501	Apoptosis; Mitophagy; IκB/IKK; Lipoxygenase; Sirtuin; COX; NADPH; DNA/RNA Synthesis; Nrf2; Antibacterial; Antibiotic; Autophagy; Antifungal	Apoptosis; Autophagy; Cell Cycle/Checkpoint; Chromatin/Epigenetic; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Microbiology/Virology; Neuroscience; NF-κB
	Resveratrol (SRT 501) 属于多酚类天然产物，是一种植物抗毒素，具有抗氧化和化学预防活性。Resveratrol 的靶点广泛，包括 COX、SIRT、LOC 等。Resveratrol 可以诱导细胞自噬和凋亡。
T15094	Dehydroaltenusin	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Dehydroaltenusin is a selective eukaryotic DNA polymerase α inhibitor and a type of antibiotic produced by a fungus (IC50: 0.68 μM). Dehydroaltenusin inhibits mammalian pol α activity.
TN5879	Edgeworin
	Edgeworin is a DNA polymerase beta (pol beta) inhibitor, it inhibits both the lyase and polymerase activities of DNA polymerase beta; it can potentiate the inhibitory action of the anticancer drug bleomycin in cultured A549 cells via an inhibition of DNA
TN6148	3-O-trans-p-Coumaroylmaslinic acid
	3-beta-O-(trans-p-Coumaroyl)maslinic acid is a DNA polymerase B" inhibitor. It shows antimicrobial activity on Gram-positive bacteria and yeasts.
TMA0984	Cerevisterol	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Cerevisterol 是一种细胞毒性类固醇，提取于Agaricus blazei 子实体，对 DNA 聚合酶 α 的活性具有抑制作用。
T36667	2'-Deoxyadenosine-5'-triphosphate dATP,Deoxyadenosine 5-triphosphate	DNA/RNA Synthesis; Endogenous Metabolite	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism
	2'-Deoxyadenosine-5'-triphosphate (Deoxyadenosine 5-triphosphate) (dATP) 是一种天然存在的小分子核苷酸，在细胞中用于DNA合成或复制。2'-Deoxyadenosine-5'-triphosphate (dATP) 是 DNA 聚合酶的底物。2'-Deoxyadenosine-5'-triphosphate 通过无活性的 α4beta4 四级结构抑制RNA。2'-Deoxyadenosine-5'-triphosphate 与心肌细胞生长有关。
T35779	Oosporein
	Oosporein is a mycotoxin that has been found inBeauveriaand has diverse biological activities.1,2It is cytotoxic to Sf9 and Sf21 insect cells with 50% cytotoxic concentration (CC50) values of 4.23 and 10.43 μM, respectively.3Oosporin induces lethality in day-old cockerels (LD50= 6.12 mg/kg).4It inhibits Na+/K+-, Ca2+-, and Mg2+-ATPase activities by 27, 52, and 100%, respectively, in equine erythrocyte ghosts when used at a concentration of 200 μg/ml.2Oosporein inhibits herpes simplex 1 (HSV-1), ...

天然产物

Neobavaisoflavone

Cat.No: T6S0139

Target: Apoptosis, DNA/RNA Synthesis

Cat.No: T3332

Synonym: 异甜菊醇,(-)-Isosteviol

Target: IL Receptor, Potassium Channel, TNF, NF-κB, Reactive Oxygen Species, COX, Topoisomerase

Cat.No: T6194

Synonym: 非达米星,Tiacumicin B,OPT-80,Clostomicin B1,PAR-101

Target: Apoptosis, DNA/RNA Synthesis, Antibacterial, Antibiotic

Cat.No: T3376

Synonym: 朝蓟糖甙,Luteoloside,Luteolin 7-β-D-Glucopyranoside,Luteolin 7-O-Glucoside,Luteolin 7-O-β-D-glucoside,木犀草苷,Luteolin 7-glucoside

Target: Others, Influenza Virus, DNA/RNA Synthesis

Cat.No: T14304

Target: Others

Cat.No: T3772

Synonym: 2α-Hydroxyoleanoic Acid,山楂酸,2α-Hydroxyoleanolic acid,Crategolic acid

Target: NF-κB, HIV Protease, DNA/RNA Synthesis, Antibacterial

2'-Deoxyadenosine-5'-triphosphate trisodium

Cat.No: T37635

Synonym: dATP trisodium

Target: DNA/RNA Synthesis, Endogenous Metabolite

Cat.No: T1272

Synonym: 阿糖胞苷,Ara-C,Cytosine Arabinoside,Cytosine β-D-arabinofuranoside,Arabinocytidine

Target: Apoptosis, Nucleoside Antimetabolite/Analog, DNA/RNA Synthesis, Endogenous Metabolite, Autophagy, HSV

Deoxythymidine-5'-triphosphate trisodium

Cat.No: T9086

Synonym: dTTP trisodium salt,thymidine 5'-(trisodium hydrogen triphosphate),胸苷-5'-三磷酸三钠盐,脱氧胸苷三磷酸三钠盐,Deoxythymidine-5'-triphosphate (dTTP) trisodium salt

Target: DNA/RNA Synthesis

Rifamycin sodium

Cat.No: T5003

Synonym: Rifamycin sodium salt,利福霉素钠

Target: Antibacterial, Antibiotic

Cat.No: T8347

Target: Reactive Oxygen Species, ROS, Antibacterial, Antibiotic

Cat.No: T1086

Synonym: Calciferol,Ergocalciferol,Ercalciol,维生素D2

Target: DNA/RNA Synthesis, Endogenous Metabolite

5-Hydroxymethyl-2'-deoxycytidine

Cat.No: T40834

Synonym: 5hmdC,2'-脱氧-5-(羟甲基)胞啶

Target: PARP

Ancitabine hydrochloride

Cat.No: T1591

Synonym: NSC 145668 HCl,盐酸环胞苷,Cyclocytidine hydrochloride,Cyclo-CMP hydrochloride,Cyclocytidine HCl,Cyclo-C

Target: Others, DNA/RNA Synthesis, Autophagy

N4-Benzoyl-2′-deoxycytidine

Cat.No: T7961

Synonym: N-苯甲酰-2'-脱氧胞苷

Target: Others

Cat.No: TN1134

Target: Apoptosis, LDL, PI3K, DNA/RNA Synthesis, NO Synthase, Prostaglandin Receptor

Cat.No: T1558

Synonym: 白藜芦醇,trans-Resveratrol,SRT 501

Target: Apoptosis, Mitophagy, IκB/IKK, Lipoxygenase, Sirtuin, COX, NADPH, DNA/RNA Synthesis, Nrf2, Antibacterial, Antibiotic, Autophagy, Antifungal

Dehydroaltenusin

Cat.No: T15094

Target: DNA/RNA Synthesis

Cat.No: TN5879

3-O-trans-p-Coumaroylmaslinic acid

Cat.No: TN6148

Cat.No: TMA0984

Target: DNA/RNA Synthesis

2'-Deoxyadenosine-5'-triphosphate

Cat.No: T36667

Synonym: dATP,Deoxyadenosine 5-triphosphate

Target: DNA/RNA Synthesis, Endogenous Metabolite

Cat.No: T35779

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