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181

抑制剂 & 化合物

32

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T8391	Cesium chloride 氯化铯,CsCl	Potassium Channel	Membrane transporter/Ion channel
	Cesium chloride (CsCl) 是一种钾通道抑制剂，可以防止 Alloxan 引起的 Na+转运减少。Cesium chloride 可以诱发心律失常。
T19031	NBD-F 4-Fluoro-7-nitrobenzofurazan	Others	Others
	NBD-F (4-Fluoro-7-nitrobenzofurazan) 是一种用于氨基酸分析 (amino acid analysis) 的前荧光试剂。它能与一级或二级胺反应生成荧光产物，从而分析氨基酸和低分子量胺。
TP1299L1	Melittin Acetate Melittin Acetate(20449-79-0 Free base),Forapin Acetate	Phospholipase	Metabolism
	Melittin Acetate (Forapin Acetate) 是一种PLA2激活剂。Melittin Acetate 低分子量 PLA2 的活性具有刺激，而不会增加高分子量 PLA2 的活性。
T21644L	AF 12198 Acetate AF 12198 Acetate (185413-30-3 Free base)	IL Receptor	Immunology/Inflammation
	AF 12198 Acetate 是一种新型的低分子量 IL-1 拮抗剂。
T26986	Cevoglitazar LBM-642,LBM 642,LBM642	PPAR	DNA Damage/DNA Repair; Metabolism
	Cevoglitazar (LBM-642) 是一种 PPARɑ 激动剂和 PPARγ激动剂。Cevoglitazar 能有效减少肥胖小鼠和猴的食物摄入量和体重。
T1856	TPT-260 Dihydrochloride TPT-260,TPT 260,NSC55712,TPT260,TPU-260 Dihydrochloride	Others	Others
	TPT-260 Dihydrochloride (NSC55712) 是一种噻吩硫脲衍生物。
TP1299	Melittin 蜂毒素,蜂毒肽	Phospholipase	Metabolism
	Melittin 是 PLA2激活剂，能够刺激低分子量 PLA2的活性，而不刺激高分子量 PLA2的活性。
T6572	Lorcaserin HCl	5-HT Receptor	GPCR/G Protein; Neuroscience
	Lorcaserin HCl 是一种选择性血清素激动剂，被批准为减肥药。
T21955	GQ-16	PPAR	DNA Damage/DNA Repair; Metabolism
	GQ-16 是 PPARγ 的部分激动剂，Ki 为 160 nM。 GQ-16 可减少脂肪生成作用并促进胰岛素敏化而不会增加体重。
T24121	GW438014A GW 438014 A,GW-438014-A	Neuropeptide Y Receptor	GPCR/G Protein; Neuroscience
	GW438014A 是一种有效且具有选择性的 NPY-Y5 受体拮抗剂。GW438014A 对食物摄入并减少肥胖啮齿动物的体重增加具有抑制作用。
T28232	Oleoylestrone Estrone 3-oleate,MP 101,MP-101,MP101	Antioxidant	oxidation-reduction
	Oleoylestrone (MP-101) 存在于血浆和脂肪组织中，具有潜在的抗氧化作用，可诱导大鼠体内脂肪的流失，可用于减肥。
TP1299L	Melittin TFA(20449-79-0(free base))	Phospholipase	Metabolism
	Melittin TFA(20449-79-0(free base)) 是一种含有 26 个氨基酸残基的小蛋白质，是蜂毒的主要毒性成分。它是一种 PLA2 活化剂，可刺激低分子量 PLA2 的活性，而不会增加高分子量 PLA2 的活性。
T1230	Pamabrom 巴马溴,帕马溴	Others	Others
	Pamabrom 是一种利尿剂，有效成分为8-bromotheophylline，能够缓解月经相关症状。
T20511	6-Thioguanosine 6-Mercaptoguanosine,NSC29422,NSC 29422,NSC-29422	Others	Others
	6-Thioguanosine (6-Mercaptoguanosine) 是一种活性核苷，是 Azathioprine 的代谢物，是低分子量凝胶剂。6-Thioguanosine 具有免疫抑制作用，可用于研究RNA 双螺旋结构的形成。
T72947	JBSNF-000028 JBSNF-000028 free base	Others	Others
	JBSNF-000028 是一种具有口服活性和有效性的烟酰胺 N-甲基转移酶 (NNMT) 抑制剂，对人 NNMT (hNNMT)、猴 NNMT (mkNNMT) 和小鼠 NNMT (mNNMT) 具有抑制作用， IC50 分别为 0.033 μM、0.19 μM 和 0.21 μM。JBSNF-000028 可驱动胰岛素敏化、葡萄糖调节和体重减，可用于研究代谢紊乱。
T9275	ART558	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	ART558 是一种高效的、选择性的、变构 DNA 聚合酶活性的 Polθ 抑制剂，IC50为7.9 nM。ART558 可用于癌症研究。
T7340	5'-N-Ethylcarboxamidoadenosine NECA,5'-N-乙基酰胺基腺苷	Adenosine Receptor	GPCR/G Protein; Neuroscience
	5'-N-Ethylcarboxamidoadenosine (NECA) 是腺苷受体的激动剂，可增加荧光素和低分子量葡聚糖的脑外渗，与血脑屏障调节无关。
T15006	Dirlotapide CP742033,Slentrol	Others; CETP	Metabolism; Others
	Dirlotapide (CP742033) 是一种肠道选择性微粒体甘油三酯转移蛋白(MTP)抑制剂。它可以减轻糖尿病狗的体重。Dirlotapide 以剂量依赖性方式减少食物摄入量，可能是通过增加肽YY 释放到循环中。
T37891L	GLP-1(32-36)amide acetate GLP-1(32-36)amide 醋酸盐,GLP-1(32-36)amide acetate(1417302-71-6 Free base)	Others	Others
	GLP-1(32-36)amide acetate 是一种五肽，衍生自糖调节激素 GLP-1 的 C 末端。GLP-1(32-36)amide acetate 可抑制糖尿病小鼠的体重增加并调节全身葡萄糖代谢。
T41298	LMPTP INHIBITOR 1 dihydrochloride	Phosphatase	Metabolism
	LMPTP INHIBITOR 1 dihydrochloride 是选择性的低分子量蛋白酪氨酸磷酸酶（LMPTP）抑制剂，抑制 LMPTP-A 活性的IC50为 0.8 μM。
T4491	LMPTP INHIBITOR 1 hydrochloride LMPTP INHIBITOR 1 hydrochloride (1908414-82-3(free base))	Phosphatase	Metabolism
	LMPTP INHIBITOR 1 hydrochloride 是一种高选择性的低分子量蛋白酪氨酸磷酸酶 (LMPTP) 抑制剂。LMPTP INHIBITOR 1 (hydrochloride) 能够抑制 LMPTP-A 的活性，IC50值为 0.8 μM。
T76559	Survodutide BI 456906	Glucagon Receptor	GPCR/G Protein
	Survodutide (BI 456906) 是一种胰高血糖素和胰高血糖素样肽 1 (GLP-1) 受体 (GLP Receptor) 双重激动剂,可降低 HbA1c16 型糖尿病的体重。
T9950	ElteN378	mTOR	PI3K/Akt/mTOR signaling
	Elte N378 是一种高效的合成 FKBP12 抑制剂，Ki 为 0.5 nM，是一种低原子量配体，其亲和力与大环内酯类雷帕霉素相当。
T15679	L 152804	Neuropeptide Y Receptor	GPCR/G Protein; Neuroscience
	L 152804 是神经肽 Y Y5 受体的特异性拮抗剂，可调节食物摄入和能量消耗，从而导致饮食诱导的肥胖小鼠体重减轻。
T83972	NOX-6-18 GPR132 antagonist 1,GPR132-B-160	GPR	Endocrinology/Hormones; GPCR/G Protein
	NOX-6-18 (GPR132-B-160) 是一种具有高效性和选择性的 GPR132 拮抗剂，具有促进胰岛素分泌活性，可以调节胰岛内的巨噬细胞重编程，减少体重增加。
T77781	Lotiglipron PF-07081532	Glucagon Receptor	GPCR/G Protein
	Lotiglipron (PF-07081532) 是一种具有口服活性和有效性的 GLP-1R 激动剂，能够降低血糖和体重，可用于研究 2 型糖尿病 (T2DM) 和过度肥胖。
TP2047L	CRF (6-33) acetate(120066-38-8 free base)	CRFR	GPCR/G Protein
	CRF (6-33) acetate(120066-38-8 free base) 是促肾上腺皮质激素释放因子结合蛋白 (CRFBP) 抑制肽；从 CRFBP 中替换 CRF。在体内抑制肥胖大鼠的体重增加并增加运动活动。
T26240	Surfen dihydrochloride Aminokinuride dihydrochloride,Aminoquinuride dihydrochloride,NSC-12155,Aminokinuride 2HCl,Aminoquinuride 2HCl	FGFR; Antiviral; Antibiotic	Angiogenesis; Immunology/Inflammation; Microbiology/Virology; Tyrosine Kinase/Adaptors
	Surfen dihydrochloride (Aminoquinuride dihydrochloride) 是一种有效的硫酸肝素小分子拮抗剂，具有抗菌和抗病毒活性，抑制炭疽致死因子、凝血因子 X 和致死因子。Surfen dihydrochloride 可抑制普通肝素和低分子量肝素的抗凝活性，抑制肝素的硫酸化和肝素裂解酶的降解。Surfen dihydrochloridn 抑制阻断硫酸乙酰肝素介导的 FGF2 结合和信号转导。Surfen 抑制 SEVI 和精液介导的 HIV 1 型感染增强。
TP2279L	Obestatin (rat) acetate	GHSR	GPCR/G Protein
	Obestatin (rat) acetate 是 G 蛋白偶联受体 39 (GPR39) 的内源性配体。它具有抗炎、抗心肌梗塞和抗氧化特性。它抑制食物摄入，抑制空肠收缩，并减少体重增加。
T10820L1	Ciraparantag acetate Ciraparantag acetate(1438492-26-2 Free base)	Others	Others
	Ciraparantag acetate 是一种抗凝逆转剂，是一种小分子，专门设计用于通过电荷-电荷相互作用与普通肝素和低分子量肝素非共价结合。它显示出与直接口服抗凝剂 (DOAC) 相似的结合特性。
T18911	Acriflavine Acriflavinium chloride 3,6-Acridinediamine mix	SARS-CoV; Antibacterial	Microbiology/Virology
	Acriflavine (Acriflavinium chloride 3,6-Acridinediamine mix) 是木瓜蛋白酶样蛋白酶（PL（pro））抑制剂，是一种用于标记高分子量 RNA 的荧光染料，具有抗菌抗癌活性，抑制 SARS-CoV-2 和其他 β 冠状病毒，可用于研究白血病。
T4681	T863 DGAT-3,DGAT-1 inhibitor	Acyltransferase; Transferase	Metabolism
	T863 (DGAT-3) 是口服有效的二酰基甘油酰基转移酶1 选择性抑制剂。T863结合DGAT1的酰基辅酶A 结合位点，抑制三酰甘油在细胞内的合成。
T3142	Drostanolone Propionate	Others	Others
	Dromostanolone propionate (Drostanolone propionate) 是一种具有抗乳腺癌活性的化合物。Dromostanolone propionate 抑制肿瘤对雌二醇 -17 的摄取，但对正常乳腺组织的摄取没有明显影响。Dromostanolone propionate 植入颗粒可使动物的体重增加，并抑制雌性动物的发情。
T38074	Thiodigalactoside	Galectin	Immunology/Inflammation
	Thiodigalactoside 是一种具有口服活性的，有效的半乳凝素 (GAL) 抑制剂，对于 GAL-1 和 GAL-3 的 Kd 值分别为 24 μM，49 μM。Thiodigalactoside 是一种不可代谢的二糖，具有抗炎和抗癌活性。Thiodigalactoside 可显着降低饮食诱发的肥胖大鼠的体重增加。
T8720	PRX-07034 hydrochloride PRX-07034	5-HT Receptor	GPCR/G Protein; Neuroscience
	PRX-07034 hydrochloride 是一种有效的高度选择性5-HT6受体拮抗剂，Ki 为 4-8 nM，IC50为 19 nM，可用于增强工作记忆和认知灵活性的研究。
T22323	Enoxaparin sodium	Thrombin	Proteases/Proteasome
	Enoxaparin sodium 是一种低分子量肝素 (LMWH)，已获得美国 FDA 批准，可用于医疗管理的 ST 段心肌梗死 (STEMI) 或 STEMI 及随后的经皮冠状动脉介入治疗 (PCI) 患者。它与抗凝血酶结合并增强其作用，并抑制凝血因子 XIa、IXa、Xa 和 IIa（凝血酶），从而防止血栓形成。
T0976	Propoxur 残杀威,Aprocarb,Propoxure,Baygon	AChR; Antifungal	Microbiology/Virology; Neuroscience
	Propoxur (Propoxure) 是一种氨基甲酸酯类杀虫剂，用于控制蟑螂、苍蝇、蚊子以及草坪和草坪昆虫。
T13647	Dextran sulfate sodium salt (MW 4500-5500) DSS,Dextran sulfate sodium salt (MW 4500-5500),硫酸葡聚糖钠盐	Apoptosis; HIV Protease	Apoptosis; Microbiology/Virology; Proteases/Proteasome
	Dextran sulfate sodium salt (MW 4500-5500) 是一种脱水葡萄糖的聚合物，分子量范围是4500-5500。Dextran sulfate sodium salt (MW 4500-5500) 通过阻止病毒吸附到宿主细胞中来抑制人免疫缺陷病毒的复制。Dextran sulfate sodium salt (MW 4500-5500) 是常用的炎症性肠病造模药物，可通过硫酸基团引起的高负电荷破坏肠黏膜屏障完整性，从而导致肠屏障受损，巨噬细胞功能失调以及菌群紊乱等现象。
T61268	Vutiglabridin HSG4112	Phosphatase	Metabolism
	Vutiglabridin (HSG4112) 是一种新型且安全的PON2调节剂，是一个外消旋化合物。Vutiglabridin 是Glabridin 的优化结构类似物，比Glabridin 在减重效果和化学稳定性方面更加优越。Vutiglabridin 通过靶向线粒体对氧磷酶-2改善mptp 诱导的帕金森病小鼠的神经变性。Vutiglabridin 是一种治疗肥胖的临床2期药物，在PD 模型中对对线粒体PON2具有治疗作用。Vutiglabridin 渗透到大脑，结合PON2，恢复1-甲基-4-苯基吡啶(MPP*)诱导的SH-SY5Y 神经母细胞瘤细胞线粒体功能障碍。Vutiglabridin 在小鼠实验中显著减轻了1-甲基-4苯基-1,2,3,6-四氢吡啶(MPTP)诱导的PD 模型小鼠的运动障碍和多巴胺能神经元损伤。
T31847	Forfenimex BF 121,BF-121,BF121
	Forfenimex is a newly discovered low molecular weight immunomodulator.
T25293	DCFBC
	DCFBC is a low-molecular-weight radiotracer. It targets prostate-specific membrane antigen (PSMA).
T12331	OT-R antagonist 2 Oxytocin receptor antagonist 2	Others	Others
	OT-R antagonist 2 is a nonpeptide low molecular weight antagonist of OT-R .
T70417	XR 1853
	XR 1853 is a low molecular weight modulator of human plasminogen activator inhibitor-1 activity.
T30268	AZD9291-345 AZD-9291345,AZD 9291345,AZD9291345
	AZD9291-345 is a compound which has a molecule weight 345, and structurally related to AZD9291.
T20274	Dibenzyl phthalate AI300364,AI3-00364
	Dibenzyl phthalate is an endocrine-disrupting chemical. It also interferes with different cell signaling pathways involved in weight and glucose homeostasis.
T10506	PPAR agonist 1	PPAR	DNA Damage/DNA Repair; Metabolism
	PPAR agonist 1 is an agonist of PPAR α/γ, used for reducing blood glucose, lipid levels, reducing body weight, and lowering cholesterol.
T75741	Melittin TFA
	Melittin TFA 是一种PLA2激活剂，可刺激低分子量 PLA2的活性，而不会提高高分子量 PLA2的活性。
T26495	AA560 AA 560,AA-560
	AA560 is a nonsteroidal antiandrogen. AA560 decreases the uptake of 3H-androgens in the ventral prostate and decreases the weight of accessory organs.
T33006	LY-104119 LY 104119,LY104119
	LY-104119 is a thermogenic weight loss compound that rapidly reduces noradrenaline concentrations in brown adipose tissue between the scapulas, the heart, and the liver.
TP2279	Obestatin(rat) Obestatin (rat)	Others	Others
	Endogenous peptide that suppresses food intake and body weight-gain

化合物

Cesium chloride

Cat.No: T8391

Synonym: 氯化铯,CsCl

Target: Potassium Channel

Cat.No: T19031

Synonym: 4-Fluoro-7-nitrobenzofurazan

Target: Others

Melittin Acetate

Cat.No: TP1299L1

Synonym: Melittin Acetate(20449-79-0 Free base),Forapin Acetate

Target: Phospholipase

AF 12198 Acetate

Cat.No: T21644L

Synonym: AF 12198 Acetate (185413-30-3 Free base)

Target: IL Receptor

Cat.No: T26986

Synonym: LBM-642,LBM 642,LBM642

Target: PPAR

TPT-260 Dihydrochloride

Cat.No: T1856

Synonym: TPT-260,TPT 260,NSC55712,TPT260,TPU-260 Dihydrochloride

Target: Others

Cat.No: TP1299

Synonym: 蜂毒素,蜂毒肽

Target: Phospholipase

Cat.No: T6572

Target: 5-HT Receptor

Cat.No: T21955

Target: PPAR

Cat.No: T24121

Synonym: GW 438014 A,GW-438014-A

Target: Neuropeptide Y Receptor

Cat.No: T28232

Synonym: Estrone 3-oleate,MP 101,MP-101,MP101

Target: Antioxidant

Melittin TFA(20449-79-0(free base))

Cat.No: TP1299L

Target: Phospholipase

Cat.No: T1230

Synonym: 巴马溴,帕马溴

Target: Others

6-Thioguanosine

Cat.No: T20511

Synonym: 6-Mercaptoguanosine,NSC29422,NSC 29422,NSC-29422

Target: Others

Cat.No: T72947

Synonym: JBSNF-000028 free base

Target: Others

Cat.No: T9275

Target: DNA/RNA Synthesis

5'-N-Ethylcarboxamidoadenosine

Cat.No: T7340

Synonym: NECA,5'-N-乙基酰胺基腺苷

Target: Adenosine Receptor

Cat.No: T15006

Synonym: CP742033,Slentrol

Target: Others, CETP

GLP-1(32-36)amide acetate

Cat.No: T37891L

Synonym: GLP-1(32-36)amide 醋酸盐,GLP-1(32-36)amide acetate(1417302-71-6 Free base)

Target: Others

LMPTP INHIBITOR 1 dihydrochloride

Cat.No: T41298

Target: Phosphatase

LMPTP INHIBITOR 1 hydrochloride

Cat.No: T4491

Synonym: LMPTP INHIBITOR 1 hydrochloride (1908414-82-3(free base))

Target: Phosphatase

Cat.No: T76559

Synonym: BI 456906

Target: Glucagon Receptor

Cat.No: T9950

Target: mTOR

Cat.No: T15679

Target: Neuropeptide Y Receptor

Cat.No: T83972

Synonym: GPR132 antagonist 1,GPR132-B-160

Target: GPR

Cat.No: T77781

Synonym: PF-07081532

Target: Glucagon Receptor

CRF (6-33) acetate(120066-38-8 free base)

Cat.No: TP2047L

Target: CRFR

Surfen dihydrochloride

Cat.No: T26240

Synonym: Aminokinuride dihydrochloride,Aminoquinuride dihydrochloride,NSC-12155,Aminokinuride 2HCl,Aminoquinuride 2HCl

Target: FGFR, Antiviral, Antibiotic

Obestatin (rat) acetate

Cat.No: TP2279L

Target: GHSR

Ciraparantag acetate

Cat.No: T10820L1

Synonym: Ciraparantag acetate(1438492-26-2 Free base)

Target: Others

Cat.No: T18911

Synonym: Acriflavinium chloride 3,6-Acridinediamine mix

Target: SARS-CoV, Antibacterial

Cat.No: T4681

Synonym: DGAT-3,DGAT-1 inhibitor

Target: Acyltransferase, Transferase

Drostanolone Propionate

Cat.No: T3142

Target: Others

Thiodigalactoside

Cat.No: T38074

Target: Galectin

PRX-07034 hydrochloride

Cat.No: T8720

Synonym: PRX-07034

Target: 5-HT Receptor

Enoxaparin sodium

Cat.No: T22323

Target: Thrombin

Cat.No: T0976

Synonym: 残杀威,Aprocarb,Propoxure,Baygon

Target: AChR, Antifungal

Dextran sulfate sodium salt (MW 4500-5500)

Cat.No: T13647

Synonym: DSS,Dextran sulfate sodium salt (MW 4500-5500),硫酸葡聚糖钠盐

Target: Apoptosis, HIV Protease

Cat.No: T61268

Synonym: HSG4112

Target: Phosphatase

Cat.No: T31847

Synonym: BF 121,BF-121,BF121

Cat.No: T25293

OT-R antagonist 2

Cat.No: T12331

Synonym: Oxytocin receptor antagonist 2

Target: Others

Cat.No: T70417

Cat.No: T30268

Synonym: AZD-9291345,AZD 9291345,AZD9291345

Dibenzyl phthalate

Cat.No: T20274

Synonym: AI300364,AI3-00364

Cat.No: T10506

Target: PPAR

Cat.No: T75741

Cat.No: T26495

Synonym: AA 560,AA-560

Cat.No: T33006

Synonym: LY 104119,LY104119

Cat.No: TP2279

Synonym: Obestatin (rat)

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T1287	Synephrine 辛弗林,Oxedrine	Endogenous Metabolite; Adrenergic Receptor	GPCR/G Protein; Metabolism; Neuroscience
	Synephrine (Oxedrine) 是来自 Citrus aurantium 的α-adrenergic 和β-adrenergic 激动剂，是一种生物碱。它也是一种拟交感神经化合物，能够用于减肥。
T12045	(-)-Hydroxycitric acid lactone 藤黄内酯,Garcinia lactone	ATP Citrate Lyase	Metabolism
	(-)-Hydroxycitric acid lactone (Garcinia lactone) 是一种有效的 ATP-柠檬酸裂解酶抑制剂，能够催化柠檬酸盐线粒体外裂解为草酰乙酸和乙酰辅酶 A，限制了脂肪酸合成所需乙酰辅酶 A 单位的可用性。它是一种减肥药，是一种广受欢迎的减肥食品补充剂。
T6688	Synephrine hydrochloride 辛弗林盐酸盐,Oxedrine hydrochloride,Synephrine HCl	Endogenous Metabolite; Adrenergic Receptor	GPCR/G Protein; Metabolism; Neuroscience
	Synephrine hydrochloride (Oxedrine hydrochloride) 是一种来自Citrus aurantium 的α-adrenergic 和β-adrenergic 激动剂的生物碱，也是一种拟交感神经化合物，能够用于减肥。
T14961	Chrysene 䓛,屈	Others	Others
	Chrysene 是高分子量 (HMW) 多环芳烃，有极强的顽固性和致癌性。
T17303	α-Cyclodextrin Alfadex,NSC269470,α-环糊精,NSC 269470,NSC-269470	Others	Others
	α-Cyclodextrin (Alfadex) 是一种多功能可溶性膳食纤维，可作为纤维原料销售。
TN6764	Simmondsin	Others	Others
	Simmondsin 是一种来自Simmondsia chinensis——荷荷巴的天然产物。它减少了大鼠的食物摄入量和体重，而没有明显的负面影响。
T19924	Rhododendrol Betuligenol,Frambinol,杜鹃醇	Others	Others
	Rhododendrol (Frambinol) 是一种黑色素合成物，防止雄性小鼠高脂饮食引起的体重升高和增加雄性小鼠白色脂肪细胞的脂肪分解。Rhododendrol 可用作美白/美白化妆品抑制剂。
T3343	5-methoxyflavone 5-methoxy-2-phenylchromen-4-one,5-甲氧基黄酮	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	5-methoxyflavone (5-methoxy-2-phenylchromen-4-one) 是一种类黄酮，是DNA 聚合酶 β 的抑制剂和 β-淀粉样蛋白毒性的神经保护剂。它通过调控嗜离子 GABAA 受体，起到镇静中枢神经系统的作用。
T3121	Betulin Trochol,betulinic alcohol,betuline,betulinol,桦木醇,Betulol,白桦脂醇	Apoptosis; Endogenous Metabolite; Lipid; Fatty Acid Synthase	Apoptosis; Metabolism
	Betulin (betulinol) 是从桦树树皮中分离出来的一种天然三萜，是 SREBP 抑制剂。
TN7079	coreopsin Butein-4-O-β-D-glucopyranoside,金鸡菊苷	Others	Others
	Coreopsin(Butein-4-O-β-D-glucopyranoside) 是金鸡菊的主要成分之一。在中国传统上被用于治疗高血压和糖尿病以及降低体重和血脂。
T8262	Fosfomycin sodium Fosfomycin Disodium,磷霉素钠	Antibacterial; Antibiotic	Microbiology/Virology
	Fosfomycin sodium 是一种能透过血脑屏障的广谱抗生素，不可逆地抑制细胞壁合成的早期阶段。它对多种细菌具有杀菌活性，包括耐多药、广泛耐药和耐全药的细菌。
T11590	(-)-Hydroxycitric acid Garcinia acid,(-)-羟基柠檬酸	ATP Citrate Lyase	Metabolism
	(-)-Hydroxycitric acid (Garcinia acid) 是Garcinia cambogia 果皮中的主要酸。它是 ATP 柠檬酸裂解酶的竞争性抑制剂，能够抑制脂肪酸的合成，减少脂肪生成，控制食物摄入，从而减轻体重。
TWS1563	Incensole	Others	Others
	Incensole 是一种 14-membered 二萜类化合物，分离自烯属植物的香精油和乳香树脂中。它能够激活脑中离子通道，并可以缓解焦虑或抑郁，从而显示出抗炎和抗抑郁的特性。
T3727	Methyl syringate Syringic Acid Methyl Ester,丁香酸甲酯	TRP/TRPV Channel	Membrane transporter/Ion channel
	Methyl syringate (Syringic Acid Methyl Ester) 是水仙花蜜的化学标记物，是有效的细菌和真菌漆酶酚介质。它也是TRPA1激动剂。
T6S0071	Fraxinellone	HIF/HIF Prolyl-Hydroxylase; STAT; PD-1/PD-L1	Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; Metabolism; Stem Cells
	Fraxinellone 是从白鲜的根皮中分离出来的一种天然产物，是PD-L1抑制剂，可抑制HIF-1α蛋白质合成。它通过靶向 PD-L1，有用于癌症免疫的潜力。
TWO2727	Propane-1,2,3-triyl tripalmitate Palmitic Triglyceride,Tripalmitin,Tripalmitoylglycerol,Glycerol Tripalmitate,三棕榈酸甘油酯	Others; Endogenous Metabolite	Metabolism; Others
	Propane-1,2,3-triyl tripalmitate (Glycerol Tripalmitate) 是内源性代谢产物的一种。
T5236	N-Methylhydantoin 甲酰乙内脲,Dioxy-creatinine,1-Methyl-hydantoin	Others; Endogenous Metabolite	Metabolism; Others
	N-Methylhydantoin (1-Methyl-hydantoin) 是一种小分子量极性物质，是细菌降解肌酐的产物。在哺乳动物中，N-Methylhydantoin 的代谢是通过 5-hydroxy-1-methylhydantoin 进行的。在一个报告的人类病例中，N-Methylhydantoin 被发现是影响智力的物质dupracetam的代谢物。
T5004	Hyaluronic acid sodium 透明质酸钠,Sodium Hyaluronate	Others	Others
	Hyaluronic acid sodium (Sodium Hyaluronate) 是一种生物聚合物，由二糖的重复单元组成，应用领域广泛。
T11589	Hydroxycitric acid tripotassium hydrate 柠檬酸钾一水合物,三水合钾柠檬酸,Potassium citrate monohydrate	ATP Citrate Lyase; HIF/HIF Prolyl-Hydroxylase; HIF	Angiogenesis; Chromatin/Epigenetic; Metabolism
	Hydroxycitric acid tripotassium hydrate (Potassium citrate monohydrate) 是一种藤黄果的主要活性成分，也是一种柠檬酸的衍生物。它可竞争性抑制柠檬酸裂解酶 (ATP citrate lyase) ，并具有减肥作用。它有效抑制结石形成，并抑制HIF，具有抗氧化，抗炎和抗肿瘤活性。
T2P2923	Stearic acid 硬脂酸,Isostearic acid,Octadecanoic acid,Cetylacetic acid	Phosphatase; Endogenous Metabolite	Metabolism
	Stearic acid (Cetylacetic acid) 是长链饱和脂肪酸，存在于许多动植物油脂中。
TN1448	(-)-Bornyl acetate L-(-)-Bornyl acetate,左旋乙酸冰片酯,Bornyl acetate,(-)-乙酸龙脑酯	p38 MAPK; NF-κB; JNK; Antifungal	MAPK; Microbiology/Virology; NF-κB
	(-)-Bornyl acetate (L-(-)-Bornyl acetate) 是存在于牛膝草油中的一种具有抗真菌活性的 (+)-Bornyl acetate 低活性异构体。
T4723	D-Tagatose 塔格糖,D-(-)-Tagatose,D-塔格糖,d-tagatos	Others; Endogenous Metabolite	Metabolism; Others
	D-Tagatose (D-(-)-Tagatose) 是自然界中发现的一种罕见的单糖，具有益生元特性。它是研究II 型糖尿病的潜在抗糖尿病药物，也是帮助提升结肠有益细菌、预防结肠癌和抑制胆固醇的益生元。它是蔗糖的替代品，也是口香糖、果汁和饮料等食品中的低热量甜味剂。
TN3989	Erycibelline	LDL; PPAR	DNA Damage/DNA Repair; Metabolism
	Erycibelline has antiobesity activity, it may be a useful therapeutic agent for body weight control by downregulating adipogenesis and lipogenesis.
T31135	Cycloechinulin
	Cycloechinulin is a diketopiperazine fungal metabolite originally isolated from A. ochraceus. It reduces weight gain of corn earworms by 33% compared to controls when used at a dose of 100 ppm in the diet.
T36348	Cerebroside C
	Cerebroside C is a fungal metabolite and glycosphingolipid that has been found in the rice pathogenic fungusM. grisea.1It induces production of the phytoalexin momilactone A when applied to wounded rice leaves, indicating that cerebroside C is an elicitor of the hypersensitive response in rice. Cerebroside C increases germination rate and reduces germination time in wheat seeds in a concentration-dependent manner at 4°C.2It also increases root length, fresh weight, and dry weight of wheat seedli...
TMA0127	Ficusin A	transporter; PPAR	DNA Damage/DNA Repair; Metabolism
	Ficusin has antioxidant, antilipidemic and antidiabetic effects, it can lower the levels of fasting blood glucose, plasma insulin, body weight gain in HFD-STZ induced diabetic rats, and can significantly enhance the PPARγ expression and improve the transl
T75425	Synephrine hemitartrate
	Synephrine (Oxedrine) hemitartrate，一种生物碱，是一种来自Citrus aurantium 的α-adrenergic 和β-adrenergic 激动剂。Synephrine hemitartrate 是一种拟交感神经化合物，可用于减肥。
T35532	Galegine hydrochloride
	Galegine hydrochloride, a guanidine derivative derived from G. officinalis, plays a role in inducing weight loss in mice and has contributed to the development of biguanides, including metformin and phenformin. This compound stimulates AMPK activation in 3T3-L1 adipocytes, L6 myotubes, H4IIE rat hepatoma, and HEK293 human kidney cell lines. Additionally, galegine hydrochloride exhibits antibacterial properties, particularly demonstrating a minimum inhibitory concentration of 4 mg/L against Staph...
TN4937	Sambutoxin	Others	Others
	Sambutoxin, a new mycotoxin produced by toxic Fusarium isolates obtained from rotted potato tubers, it can cause toxic effects in rats, including body weight loss, feed refusal, hemorrhage in the stomach and intestines, and, finally, death when rats were
T83916	Cytogenin
	Cytogenin（一种源自S. eurocidicum的香豆素衍生物）具有多种生物活性。在每日给药25 mg/kg剂量下，能减轻Ehrlich鼠自发性腺癌模型的肿瘤重量。在体内，Cytogenin（每日30和100 mg/kg）可减少链脲佐菌素诱导的体重下降和血浆葡萄糖水平上升，以及小鼠糖尿病模型中巨噬细胞胰腺浸润。同时，在每日100 mg/kg的剂量下，能降低小鼠巨噬细胞中zymosan和LPS诱导的一氧化氮产生，及LPS诱导的Il-6水平增加。
T37770	Taurohyodeoxycholic acid
	Taurohyodeoxycholic acid (THDCA) is a taurine-conjugated form of the secondary bile acid hyodeoxycholic acid .1THDCA decreases the size and weight of human gallstonesin vitro. It increases bile flow, biliary cholesterol secretion, and biliary lipid secretion in rats.2Co-administration of THDCA with taurochenodeoxycholic acid prevents TCDCA-induced hepatotoxicity, increasing bile flow as well as biliary acid and phospholipid secretion in rats.3THDCA also reduces myeloperoxidase activity, expressi...
T35741	Gliovirin
	Gliovirin is a fungal metabolite that has been found inT. harzianumand has fungicidal, antimicrobial and anti-inflammatory activities.1It is active against the plant pathogenic fungusP. ultimum(MIC = 60 ng/ml) and the parasiteT. brucei brucei(IC50= 90 ng/ml), but has no effect on the plant pathogenic fungiR. solani,P. omnivorum,T. basicola,R. arrhizus, andV. dahliaeor the bacteriaB. thuringiensis,P. fluorescens, andX. malvacearumwhen used at concentrations up to 1,000 ng/ml.2,3Gliovirin decrease...

天然产物

Cat.No: T1287

Synonym: 辛弗林,Oxedrine

Target: Endogenous Metabolite, Adrenergic Receptor

(-)-Hydroxycitric acid lactone

Cat.No: T12045

Synonym: 藤黄内酯,Garcinia lactone

Target: ATP Citrate Lyase

Synephrine hydrochloride

Cat.No: T6688

Synonym: 辛弗林盐酸盐,Oxedrine hydrochloride,Synephrine HCl

Target: Endogenous Metabolite, Adrenergic Receptor

Cat.No: T14961

Synonym: 䓛,屈

Target: Others

α-Cyclodextrin

Cat.No: T17303

Synonym: Alfadex,NSC269470,α-环糊精,NSC 269470,NSC-269470

Target: Others

Cat.No: TN6764

Target: Others

Cat.No: T19924

Synonym: Betuligenol,Frambinol,杜鹃醇

Target: Others

5-methoxyflavone

Cat.No: T3343

Synonym: 5-methoxy-2-phenylchromen-4-one,5-甲氧基黄酮

Target: DNA/RNA Synthesis

Cat.No: T3121

Synonym: Trochol,betulinic alcohol,betuline,betulinol,桦木醇,Betulol,白桦脂醇

Target: Apoptosis, Endogenous Metabolite, Lipid, Fatty Acid Synthase

Cat.No: TN7079

Synonym: Butein-4-O-β-D-glucopyranoside,金鸡菊苷

Target: Others

Fosfomycin sodium

Cat.No: T8262

Synonym: Fosfomycin Disodium,磷霉素钠

Target: Antibacterial, Antibiotic

(-)-Hydroxycitric acid

Cat.No: T11590

Synonym: Garcinia acid,(-)-羟基柠檬酸

Target: ATP Citrate Lyase

Cat.No: TWS1563

Target: Others

Methyl syringate

Cat.No: T3727

Synonym: Syringic Acid Methyl Ester,丁香酸甲酯

Target: TRP/TRPV Channel

Cat.No: T6S0071

Target: HIF/HIF Prolyl-Hydroxylase, STAT, PD-1/PD-L1

Propane-1,2,3-triyl tripalmitate

Cat.No: TWO2727

Synonym: Palmitic Triglyceride,Tripalmitin,Tripalmitoylglycerol,Glycerol Tripalmitate,三棕榈酸甘油酯

Target: Others, Endogenous Metabolite

N-Methylhydantoin

Cat.No: T5236

Synonym: 甲酰乙内脲,Dioxy-creatinine,1-Methyl-hydantoin

Target: Others, Endogenous Metabolite

Hyaluronic acid sodium

Cat.No: T5004

Synonym: 透明质酸钠,Sodium Hyaluronate

Target: Others

Hydroxycitric acid tripotassium hydrate

Cat.No: T11589

Synonym: 柠檬酸钾一水合物,三水合钾柠檬酸,Potassium citrate monohydrate

Target: ATP Citrate Lyase, HIF/HIF Prolyl-Hydroxylase, HIF

Cat.No: T2P2923

Synonym: 硬脂酸,Isostearic acid,Octadecanoic acid,Cetylacetic acid

Target: Phosphatase, Endogenous Metabolite

(-)-Bornyl acetate

Cat.No: TN1448

Synonym: L-(-)-Bornyl acetate,左旋乙酸冰片酯,Bornyl acetate,(-)-乙酸龙脑酯

Target: p38 MAPK, NF-κB, JNK, Antifungal

Cat.No: T4723

Synonym: 塔格糖,D-(-)-Tagatose,D-塔格糖,d-tagatos

Target: Others, Endogenous Metabolite

Cat.No: TN3989

Target: LDL, PPAR

Cat.No: T31135

Cat.No: T36348

Cat.No: TMA0127

Target: transporter, PPAR

Synephrine hemitartrate

Cat.No: T75425

Galegine hydrochloride

Cat.No: T35532

Cat.No: TN4937

Target: Others

Cat.No: T83916

Taurohyodeoxycholic acid

Cat.No: T37770

Cat.No: T35741

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