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134

抑制剂 & 化合物

17

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T39009	CAP18 (rabbit) CAP18 (rabbit)
	CAP18 (rabbit) is a 37 amino acid antimicrobial peptide derived from rabbit granulocytes. It exhibits extensive antimicrobial activity against both Gram-positive (IC50, 130-200 nM) and Gram-negative (IC50, 20-100 nM) bacteria. Thus, CAP18 (rabbit) holds promise for the study and advancement of bacterial sepsis research.
TP1175	Endothelin-3, human, mouse, rabbit, rat Endothelin 3 (Rat,Human)
	Endothelin-3, human, mouse, rabbit, rat , is a cyclic 21 amino acid peptide. It is an endogenous neuropeptide and potent vasoconstrictor.
TP1173	Endothelin 3 (Rat,Human) (TFA) Endothelin-3, human, mouse, rabbit, rat TFA
	Endothelin-3, human, mouse, rabbit, rat TFA is a 21-amino acid vasoactive peptide that specifically interacts with G-protein-linked transmembrane receptors, ET-RA and ET-RB.
T34862	Thromboxane A2 Rabbit aorta contracting substance,TXA-2,TXA2,TXA 2
	Thromboxane A2, as an unstable intermediate between the prostaglandin endoperoxides and thromboxane B2, is a potent inducer of platelet aggregation and causes vasoconstriction.
T16420	P-1075	Potassium Channel	Membrane transporter/Ion channel
	P-1075 是磺酰脲受体2相关的 ATP 敏感性的钾通道(SUR2-KIR6)的激活剂，EC50为 45 nM。它在兔子中通过打开线粒体 K (ATP) 通道产生活性氧，产生保护心脏的功效。
TP1016	Aviptadil Vasoactive Intestinal Peptide (human, rat, mouse, rabbit, canine, porcine),阿肽地尔
	Aviptadil (INN) is an analog of vasoactive intestinal polypeptide (VIP) for the treatment of erectile dysfunction.
T81316	Rabbit neutrophil peptide 3b
	Rabbit Neutrophil Peptide 3b，一种源自兔腹膜中性粒细胞的抗菌肽。
T1736	Apixaban 阿哌沙班,BMS-562247-01	Factor Xa	Metabolism
	Apixaban (BMS-562247-01) 是一种高度选择性，可逆的、口服具有活力的凝血因子 Xa (Factor Xa) 抑制剂，抑制人和兔凝血因子 Xa 的 Ki 分别为 0.08 nM 和 0.17 nM。它可以用于研究各种血栓栓塞疾病。
T81317	Rabbit IgG1 kappa, Isotype Control
	RabbitIgG1kappa, Isotype Control为兔源IgG1κ同型对照单克隆抗体，用于科研中作为Rabbit IgG1κ抗体的实验对照。
T7530	PD146176 NSC168807	Ferroptosis; Lipoxygenase; Autophagy	Apoptosis; Autophagy; Metabolism
	PD146176 (NSC-168807) 是一种 15-脂氧合酶(15-LO)抑制剂，抑制兔网织红细胞 15-LO，Ki 为 197 nM，IC50 为 0.54 μM。它通过刺激老年三重转基因小鼠的自噬来逆转认知障碍、脑淀粉样变性和 tau 病理学。
T76500	ACTH (3-24) (human, bovine, mouse, ovine, porcine, rabbit, rat)
	ACTH (3-24) (human, bovine, mouse, ovine, porcine, rabbit, rat) 是ACTH的3-24片段，适用于癌症、免疫疾病、心血管疾病等多种疾病的研究。
T64611	Acetyl-Histone H3 (Lys9) (C5B11) Rabbit mAb #9649R
	Acetyl-Histone H3 (Lys9) (C5B11) Rabbit mAb #9649R 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T64611。
T64587	p44/42 MAPK (Erk1/2) (137F5) Rabbit mAb #4695R
	p44/42 MAPK (Erk1/2) (137F5) Rabbit mAb #4695R 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T64587。
T81591	Osteostatin (1-5) amide (human, bovine, dog, horse, mouse, rabbit, rat) Human PTHrP(107-111) amide
	Osteostatin (1-5) amide (human, bovine, dog, horse, mouse, rabbit, rat) (Human PTHrP (107-111) amide) 是一段具有抑制骨吸收作用的C端甲状旁腺激素相关蛋白片段。
T64608	Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (20G11) Rabbit mAb #4376R
	Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (20G11) Rabbit mAb #4376R 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T64608。
TP1016L	Aviptadil Acetate 醋酸阿肽地尔,阿肽地尔,Vasoactive Intestinal Peptide acetate salt	RAAS; SARS-CoV	Endocrinology/Hormones; Microbiology/Virology
	Aviptadil Acetate (Vasoactive Intestinal Peptide acetate salt) 是模拟血管活性肠多肽类似物，具有血管舒张效应。它可诱导肺血管舒张并抑制血管 SMC 的增殖和血小板聚集。它可用于研究 SARS-CoV-2 引起的肺纤维化、肺动脉高压和呼吸衰竭。
T17196	UC-1728 t-TUCB	Epoxide Hydrolase	Metabolism
	UC-1728 (t-TUCB) 是一种兔子可溶性环氧化物水解酶抑制剂，兔子肝脏中测得其IC50=2 nM。
T13373	YM17E	Acyltransferase; AChR	Metabolism; Neuroscience
	YM17E 是一种 ACAT 抑制剂，在体外兔肝微粒体中的 IC50 为 44 nM。
T3757	NQ301	Thrombin; Platelet aggregation	Others; Proteases/Proteasome
	NQ301 是一种抗血栓剂，能够抑制胶原蛋白激发的兔血小板聚集，IC50=10 mg/mL。
T16411	Otenzepad AF-DX 116	AChR	Neuroscience
	Otenzepad (AF-DX 116) 是 M2 mAChR 的特异性拮抗剂，对大鼠心脏和兔外周肺的 IC50 分别为 386 nM 和 640 nM。
T12767	RP 70676	Acyltransferase	Metabolism
	RP 70676 是ACAT 抑制剂，抑制大鼠和兔子中 ACAT 的IC50分别为 25 和 44 nM。
T16394	ONO-5334	Cysteine Protease	Proteases/Proteasome
	ONO-5334 is an effective and selective cathepsin K inhibitor (Ki: 0.10 nM, 0.049 nM, and 0.85 nM for human, rabbit, and rat cathepsin K, respectively). ONO-5334 has the potential for the study of osteoporosis.
T14953	Chloroquinoxaline sulfonamide NSC-339004,Chloroquinoxaline	Topoisomerase	DNA Damage/DNA Repair
	Chloroquinoxaline sulfonamide is a topoisomerase II alpha/beta poison. It is used to control coccidiosis in poultry, rabbit, sheep, and cattle.
T67805	Oxepinac
	oxepinac 是一种治疗疼痛性骨关节炎的有效且耐受性良好的化合物。oxepinac 在动物实验中对小鼠和家兔胎儿无致畸作用。
TQ0038	Brensocatib AZD7986,INS 1007	Proteasome	Proteases/Proteasome; Ubiquitination
	Brensocatib (AZD7986) 是一种二肽基肽酶 1 (DPP1) 抑制剂，在人，小鼠，大鼠，狗和兔中的pIC50分别为 6.85, 7.6, 7.7, 7.8 和 7.8。
TP1917L1	Sar-[D-Phe8]-des-Arg9-Bradykinin acetate Sar-[D-Phe8]-des-Arg9-Bradykinin acetate(126959-88-4 free base)	Bradykinin Receptor	GPCR/G Protein
	Sar-[D-Phe8]-des-Arg9-Bradykinin acetate(126959-88-4 free base) 是一种有效的选择性缓激肽 B1 受体激动剂（兔主动脉中的 EC50 = 9.02 nM），对氨肽酶、激肽酶 I 和 II (ACE) 以及中性内肽酶切割具有抗性。在体内表现出降血压和血管生成活性。
T15338	Foropafant SR27417,福罗帕泛	Others; Platelet aggregation	Others
	Foropafant (SR27417) 是一种高效和特异性的血小板活化因子 (PAF) 受体拮抗剂 (Ki: 57 pM)。 Foropafant 有效抑制 PAF 诱导的兔和人血小板聚集。
T31597	Ecabapide DQ2511,DQ 2511,DQ-2511	Others	Others
	Ecabapide (DQ-2511) 是一种新型促胃肠蠕动剂，能显著增强SHRSP的胃排空能力。Ecabapide 可激活的兔胃壁细胞中的环状 GMP 依赖性管家 Cl- 通道。
T22964	Glemanserin MDL11939	5-HT Receptor	GPCR/G Protein; Neuroscience
	Glemanserin (MDL11939) 是一种特异性 5-HT2A 拮抗剂，对兔、人和大鼠 5-HT2A 的 Ki 值为 0.54 nM、2.5 nM 和 2.89 nM。
T14506	BAY 60-6583	Others; Adenosine Receptor	GPCR/G Protein; Neuroscience; Others
	BAY 60-6583 是一种强效、高亲和力的腺苷 A2B 受体激动剂（EC50 = 3 nM），对A2B 受体的亲和力超过对 A1、A2A 和 A3 受体的亲和力。BAY 60-6583 在心肌缺血模型中具有心脏保护作用。BAY 60-6583 与小鼠、兔子和狗 A2BAR 的结合 Ki 值分别为 750 nM、340 nM 和 330 nM。
T16865	SCH28080	ATPase; Proton pump	Membrane transporter/Ion channel
	SCH28080 是一种可逆且具有 K+ 竞争性的胃 H+/K+-ATP 酶 (H+/K+-ATPase) 抑制剂，IC50 值为 20 nM (家兔微粒体膜)。SCH28080 在体内是有效的酸分泌抑制剂，具有抗溃疡活性、抗分泌和细胞保护活性。
T6236	Ozagrel 奥扎格雷,OKY-046,Domenan	Thrombin; Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation; Proteases/Proteasome
	Ozagrel (Domenan) 是血栓烷 A2(TXA2) 合酶抑制剂，可抑制哮喘。它也是一种抗血小板剂，可选择性抑制人血小板聚集，IC50为 53.12 μM。
T30249	AZD 7009 AZD-7009,AZD7009	Sodium Channel	Membrane transporter/Ion channel
	AZD 7009是一种新型抗心律失常化合物，对CHO K1细胞中 hNav1.5的钠电流具有抑制作用，IC50为11 uM。AZD 7009 对离体兔心房和心室肌细胞的晚期钠电流具有抑制作用，对e -4031诱导的动作电位持续时间延长具有抑制作用，促使浦肯野纤维的早期后去极化(EADs)。
T11918L	Lysipressin acetate(50-57-7(fb_acetate)) Lysine vasopressin acetate,[Lys8]-Vasopressin acetate	Others	Others
	Lysipressin acetate(50-57-7(fb_acetate)) ([Lys8]-Vasopressin acetate) 诱导兔膀胱平滑肌收缩，激活腺苷酸环化酶。 Lysipressin 是一种抗利尿激素，已在猪和一些有袋动物家族中发现。
T22530	6-Chloromelatonin	Melatonin Receptor; Dopamine Receptor	GPCR/G Protein; Neuroscience
	6-Chloromelatonin 是一种有效的褪黑素受体 (melatonin receptor) 激动剂，是一种5-甲氧基吲哚化合物，可竞争兔视网膜中相同的突触前褪黑激素受体位点，可抑制[3H]多巴胺的钙依赖性释放具有比褪黑素更高的代谢稳定性。6-Chloromelatonin 竞争 [3H] 褪黑素与 MT2 受体结合 (pKi=9.77)，可能用于研究与抑郁症相关的失眠和睡眠障碍。
T21871	MMPSI Caspase-3/7 Inhibitor I	Apoptosis; Caspase	Apoptosis; Proteases/Proteasome
	MMPSI (Caspase-3/7 Inhibitor I) 是一种新型的、非肽类的小分子 caspase 3 和 caspase 7 抑制剂，可减少离体兔心脏或心肌细胞缺血性损伤的作用，以浓度依赖性方式抑制 H16c2 细胞凋亡。MMPSI 可用于研究心脏保护和心肌损伤。
T60536	Terodiline
	Terodiline 是一种钙通道阻滞剂和 M1 选择性毒蕈碱受体 (mAChR) 拮抗剂，在在兔输精管 (M1)、心房 (M2)、膀胱 (M3) 和回肠肌肉中的 Kb 分别为 15、160、280 和 198 nM。 Terodiline 具有治疗尿频和急迫性尿失禁的潜力 [1]。
T16240	N,N'-Diacetyl-L-cystine (Ac-Cys-OH)2,DiNAC	Others	Others
	N,N'-Diacetyl-L-cystine (DiNAC) 是一种具有免疫调节特性的 N-乙酰基半胱氨酸的二硫二聚体。它在高脂血症兔中也具有抗动脉粥样硬化的作用。它是啮齿类动物中接触敏感/迟发型超敏反应的有效口服活性调节剂。
T35841	5-Benzyloxygramine	Dopamine Receptor; 5-HT Receptor	GPCR/G Protein; Neuroscience
	5-Benzyloxygramine 是一种 N 蛋白、蛋白互作的原位稳定剂，具有抗病毒和稳定 N-NTD 蛋白的作用。它能够阻断多巴胺受体，可拮抗 5-HT 对大鼠子宫和兔耳的作用。
TP1937L1	RFRP-1 (human) acetate(311309-25-8 free base)	Neuropeptide Y Receptor	GPCR/G Protein; Neuroscience
	RFRP-1 (human) acetate(311309-25-8 free base) 是一种有效的内源性 NPFF 受体激动剂（NPFF2 和 NPFF1 的 EC50 值分别为 0.0011 和 29 nM）。它减弱离体大鼠和兔心肌细胞的收缩功能。降低心率、每搏输出量、射血分数和心输出量，并增加大鼠的血浆催乳素水平。 GnIH 同系物。
T10421	AVE5688	Phosphorylase	Metabolism
	AVE5688 是糖原磷酸化酶 (glycogen phosphorylase (GP)) 抑制剂，抑制兔肌肉糖原磷酸化酶 rmGPb 和 rmGPa 的活性，IC50 值分别为 430 nM 和 915 nM，Kd 值分别为 170 nM 和 530 nM；AVE5688 可用于二型糖尿病的研究。
T24906L	Tuna AI acetate	Angiotensin-converting Enzyme (ACE)	Metabolism
	Tuna AI acetate 是一种源自金枪鱼肌肉的非竞争性血管紧张素转换酶 (ACE) 抑制剂。
T6035	Odanacatib 奥达卡替,奥当卡替,MK-0822	Cysteine Protease	Proteases/Proteasome
	Odanacatib 是组织蛋白酶K（人/兔）的选择性抑制剂，IC50分别为0.2 nM 和 1 nM。
T13369	YM-264	Others	Others
	YM-264 is a selective and orally active antagonist of platelet-activating factor (PAF) (pKi value of 8.85 for rabbit platelet membranes).
T13160	Timegadine 替美加定,SR1368	COX	Immunology/Inflammation; Neuroscience
	Timegadine is a competitive inhibitor of COX and lipo-oxygenase, with IC50s ranging from 5 nM (washed rabbit platelets) to 20 μM (rat brain) for COX and 100 μM for lipo-oxygenase both in the cytosol fraction of horse platelet homogenates and in washed rabbit platelets.
T20697	Robenidine Chimcoccide,Khimcoccid
	Robenidine, an anticoccidial guanidine, is used as an additive in rabbit fodder.
T39223	Milvexian JNJ-70033093,BMS-986177
	Milvexian (BMS-986177) is a potent antithrombotic compound that inhibits human and rabbit factor XIa (FXIa) directly and reversibly. It is orally-bioavailable and exhibits a K i of 0.11 nM and 0.38 nM against human and rabbit FXIa, respectively.
T27574	ZM 169369 ICI169369,ICI-169369
	ICI 169369, a 5-HT2/5-HT1C antagonist, can evoke endothelium-dependent relaxation in rabbit aorta.
T37210	5-hydroxy Indomethacin
	5-hydroxy Indomethacin is a metabolite of indomethacin .1It is formed from indomethacin in rabbit hepatic microsomes. 1.Evans, M.A., Papazafiratou, C., Bhat, R., et al.Indomethacin metabolism in isolated neonatal and fetal rabbit hepatocytesPediatr. Res.15(11)1406-1410(1981)
T26621	AMP-579 RPR100579,RPR 100579,AMP 579,RPR-100579
	AMP-579 is an adenosine A1 receptor agonist. AMP-579 also acts as a A2b-adenosine receptor agonist in human 293 cells and rabbit hearts.

化合物

CAP18 (rabbit)

Cat.No: T39009

Synonym: CAP18 (rabbit)

Endothelin-3, human, mouse, rabbit, rat

Cat.No: TP1175

Synonym: Endothelin 3 (Rat,Human)

Endothelin 3 (Rat,Human) (TFA)

Cat.No: TP1173

Synonym: Endothelin-3, human, mouse, rabbit, rat TFA

Cat.No: T34862

Synonym: Rabbit aorta contracting substance,TXA-2,TXA2,TXA 2

Cat.No: T16420

Target: Potassium Channel

Cat.No: TP1016

Synonym: Vasoactive Intestinal Peptide (human, rat, mouse, rabbit, canine, porcine),阿肽地尔

Rabbit neutrophil peptide 3b

Cat.No: T81316

Cat.No: T1736

Synonym: 阿哌沙班,BMS-562247-01

Target: Factor Xa

Rabbit IgG1 kappa, Isotype Control

Cat.No: T81317

Cat.No: T7530

Synonym: NSC168807

Target: Ferroptosis, Lipoxygenase, Autophagy

ACTH (3-24) (human, bovine, mouse, ovine, porcine, rabbit, rat)

Cat.No: T76500

Acetyl-Histone H3 (Lys9) (C5B11) Rabbit mAb #9649R

Cat.No: T64611

p44/42 MAPK (Erk1/2) (137F5) Rabbit mAb #4695R

Cat.No: T64587

Osteostatin (1-5) amide (human, bovine, dog, horse, mouse, rabbit, rat)

Cat.No: T81591

Synonym: Human PTHrP(107-111) amide

Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (20G11) Rabbit mAb #4376R

Cat.No: T64608

Aviptadil Acetate

Cat.No: TP1016L

Synonym: 醋酸阿肽地尔,阿肽地尔,Vasoactive Intestinal Peptide acetate salt

Target: RAAS, SARS-CoV

Cat.No: T17196

Synonym: t-TUCB

Target: Epoxide Hydrolase

Cat.No: T13373

Target: Acyltransferase, AChR

Cat.No: T3757

Target: Thrombin, Platelet aggregation

Cat.No: T16411

Synonym: AF-DX 116

Target: AChR

Cat.No: T12767

Target: Acyltransferase

Cat.No: T16394

Target: Cysteine Protease

Chloroquinoxaline sulfonamide

Cat.No: T14953

Synonym: NSC-339004,Chloroquinoxaline

Target: Topoisomerase

Cat.No: T67805

Cat.No: TQ0038

Synonym: AZD7986,INS 1007

Target: Proteasome

Sar-[D-Phe8]-des-Arg9-Bradykinin acetate

Cat.No: TP1917L1

Synonym: Sar-[D-Phe8]-des-Arg9-Bradykinin acetate(126959-88-4 free base)

Target: Bradykinin Receptor

Cat.No: T15338

Synonym: SR27417,福罗帕泛

Target: Others, Platelet aggregation

Cat.No: T31597

Synonym: DQ2511,DQ 2511,DQ-2511

Target: Others

Cat.No: T22964

Synonym: MDL11939

Target: 5-HT Receptor

Cat.No: T14506

Target: Others, Adenosine Receptor

Cat.No: T16865

Target: ATPase, Proton pump

Cat.No: T6236

Synonym: 奥扎格雷,OKY-046,Domenan

Target: Thrombin, Prostaglandin Receptor

Cat.No: T30249

Synonym: AZD-7009,AZD7009

Target: Sodium Channel

Lysipressin acetate(50-57-7(fb_acetate))

Cat.No: T11918L

Synonym: Lysine vasopressin acetate,[Lys8]-Vasopressin acetate

Target: Others

6-Chloromelatonin

Cat.No: T22530

Target: Melatonin Receptor, Dopamine Receptor

Cat.No: T21871

Synonym: Caspase-3/7 Inhibitor I

Target: Apoptosis, Caspase

Cat.No: T60536

N,N'-Diacetyl-L-cystine

Cat.No: T16240

Synonym: (Ac-Cys-OH)2,DiNAC

Target: Others

5-Benzyloxygramine

Cat.No: T35841

Target: Dopamine Receptor, 5-HT Receptor

RFRP-1 (human) acetate(311309-25-8 free base)

Cat.No: TP1937L1

Target: Neuropeptide Y Receptor

Cat.No: T10421

Target: Phosphorylase

Tuna AI acetate

Cat.No: T24906L

Target: Angiotensin-converting Enzyme (ACE)

Cat.No: T6035

Synonym: 奥达卡替,奥当卡替,MK-0822

Target: Cysteine Protease

Cat.No: T13369

Target: Others

Cat.No: T13160

Synonym: 替美加定,SR1368

Target: COX

Cat.No: T20697

Synonym: Chimcoccide,Khimcoccid

Cat.No: T39223

Synonym: JNJ-70033093,BMS-986177

Cat.No: T27574

Synonym: ICI169369,ICI-169369

5-hydroxy Indomethacin

Cat.No: T37210

Cat.No: T26621

Synonym: RPR100579,RPR 100579,AMP 579,RPR-100579

Cat. No.	Product Name	Target	Signaling Pathways
T4850	PCL 016 2-吡啶甲酸,2-Picolinic acid	Virus Protease; Endogenous Metabolite	Metabolism; Microbiology/Virology
	PCL 016 (2-Picolinic acid) 是一种局部抗病毒剂，可抑制兔体内的腺病毒复制。
TN1528	Cotoin	AChE	Neuroscience
	Cotoin 是从 Garcinia virgate 茎皮中分离出的一种天然产物。Cotoin 具有解痉活性，可降低孤立的兔肠的音调和收缩。它部分抑制乙酰胆碱、毛果芸香碱和 BaCl 对分离肠的影响。
T7030	anemarsaponin B 知母皂苷B,知母皂苷 B	p38 MAPK; NF-κB; MEK; COX; NO Synthase	Immunology/Inflammation; MAPK; Neuroscience; NF-κB
	Anemarsaponin B 是一种甾体皂苷，可降低iNOS 和COX-2的蛋白和 mRNA 水平，减少促炎细胞因子的表达和产生。它通过阻断 IκBα 的磷酸化来抑制NF-κB 的 p65 亚基的核转位，还抑制 MAP 激酶激酶 3/6 (MKK3/6) 和混合谱系激酶 3 的磷酸化。
T3S1967	(S)-Indoximod N-ME-Tryptophan,Abrine,相思豆碱,L-Abrine	Others; Indoleamine 2,3-Dioxygenase (IDO)	Metabolism; Others
	(S)-Indoximod (L-Abrine) 是一种吲哚胺-2,3-双加氧酶 (IDO) 抑制剂，可用于研究癌症。
T6S0033	Crotonoside 巴豆苷；异鸟苷,巴豆苷,Isoguanosine,2-HYDROXYADENOSINE	Others; FLT; HDAC	Angiogenesis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Others; Tyrosine Kinase/Adaptors
	Crotonoside (Isoguanosine) 是从中草药巴豆中分离出来的一种天然产物。它抑制 FLT3 和 HDAC3/6，有治疗急性髓性白血病 (AML)的研究潜力。
TN6575	Pilosidine
	Pilosidine has vasoconstrictor activity, it showed facilitating effect on adrenaline evoked contractions in rabbit aorta isolated preparations.
T27436	GS 389 GS-389,GS389
	GS 389 is a novel tetrahydroisoquinoline analog with vasorelaxant properties. GS-389 significantly inhibited cGMP phosphodiesterase from the rabbit brain and increased cGMP levels in the rat aorta.
T10913	Cyclobuxine D	Others	Others
	Cyclobuxine D is a steroidal alkaloid extracted from Buxus microphylla. Cyclostatin D has obvious bradycardia effect on rat heart, and inhibits acetylcholine and Ba ++ induced longitudinal muscle contraction isolated from rabbit jejunum.
TN1980	Neocryptotanshinone	Others	Others
	Neocryptotanshinone inhibits rabbit platelet aggregation induced by arachidonic acid.
TN4794	Pinusolidic acid	PAFR	GPCR/G Protein
	Pinusolidic acid shows a potent inhibitory effect on platelet activating factor (PAF) binding to rabbit platelets (IC50 = 2.3 x 10(-5) M, 7.48 +/- 2.11 micrograms/ml).
T75570	Justicidin C
	Justicidin C 是一种抗病毒木脂素，对水泡性口炎病毒展现了较强的抗病毒活性，同时在兔肺细胞(RL-33)中显示较低的细胞毒性。
T79950	Piperulin A
	Piperulin A，作为一种有效的PAFR抑制剂，其通过抑制兔血小板质膜上PAFR的特异性结合，展现出其功能，IC50值为7.3 μM。
TN3568	Calceolarioside A	Calcium Channel; Antifection	Membrane transporter/Ion channel; Metabolism; Microbiology/Virology
	Calceolarioside A shows potent activity against visceral leishmaniasis. It can induce a dose-related aggregant effect on rabbit platelets, which may be partly related to a calcium-dependent mechanism. Calceolarioside A also has potent antioxidative activi
T83460	11-O-β-D-glucopyranosyl thamnosmonin
	11-O-β-D-glucopyranosyl thamnosmonin是一种香豆素苷，能够从Angelica apaensis根部提取。该化合物对PAF、AA和ADP诱发的兔血小板聚集表现出轻度的抑制效果。
TN4937	Sambutoxin	Others	Others
	Sambutoxin, a new mycotoxin produced by toxic Fusarium isolates obtained from rotted potato tubers, it can cause toxic effects in rats, including body weight loss, feed refusal, hemorrhage in the stomach and intestines, and, finally, death when rats were
T38330	Collinin
	Collinin is a coumarin that has been found in Z. schinifolium and has diverse biological activities.1,2,3,4 It is active against drug-susceptible and -resistant strains of M. tuberculosis (MIC50s = 3.13-6.25 μg/ml).1 Collinin inhibits LPS-induced nitric oxide (NO) production (IC50 = 5.9 μM) and reduces COX-2 protein levels in RAW 264.7 cells.2 It completely inhibits aggregation of isolated rabbit platelets induced by arachidonic acid , collagen, or platelet activating factor (PAF) when used at a...
T83915	Norbixin hydrate
	Norbixin是一种在B. orellana中发现的类胡萝卜素，具有多样的生物活性。在无细胞测试中，它与过氧化物酶体增殖物激活受体γ (PPARγ)结合（Ki = 1.15 µM）。在心脑血管代谢综合征大鼠模型中，Norbixin (47.7 mg/kg) 能够减轻高血糖、高胰岛素血症和胰岛素抗性，降低血清脂质水平及心脏中硫代巴比妥酸反应性物质（TBARS）和谷胱甘肽（GSH）的水平。在胆固醇诱导的动脉粥样硬化兔模型中，它降低氧化型LDL和主动脉蛋白氧化水平，并减少动脉粥样硬化面积。Norbixin（每天0.1和1 mg/kg）减少汞诱导的大鼠肝细胞和白细胞DNA损伤。此外，它还能预防与年龄相关的黄斑变性（AMD）Abca4-/- Rdh8-/-小鼠模型中的光感受器退化。

天然产物

Cat.No: T4850

Synonym: 2-吡啶甲酸,2-Picolinic acid

Target: Virus Protease, Endogenous Metabolite

Cat.No: TN1528

Target: AChE

anemarsaponin B

Cat.No: T7030

Synonym: 知母皂苷B,知母皂苷 B

Target: p38 MAPK, NF-κB, MEK, COX, NO Synthase

Cat.No: T3S1967

Synonym: N-ME-Tryptophan,Abrine,相思豆碱,L-Abrine

Target: Others, Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: T6S0033

Synonym: 巴豆苷；异鸟苷,巴豆苷,Isoguanosine,2-HYDROXYADENOSINE

Target: Others, FLT, HDAC

Cat.No: TN6575

Cat.No: T27436

Synonym: GS-389,GS389

Cat.No: T10913

Target: Others

Neocryptotanshinone

Cat.No: TN1980

Target: Others

Pinusolidic acid

Cat.No: TN4794

Target: PAFR

Cat.No: T75570

Cat.No: T79950

Calceolarioside A

Cat.No: TN3568

Target: Calcium Channel, Antifection

11-O-β-D-glucopyranosyl thamnosmonin

Cat.No: T83460

Cat.No: TN4937

Target: Others

Cat.No: T38330

Norbixin hydrate

Cat.No: T83915

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