100
23
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T38831 |
Endoplasmic reticulum dye 1
|
||
Endoplasmic reticulum dye 1 is a highly effective live cell imaging agent used for detecting exocytotic events occurring at the plasma membrane. This compound exhibits minimal cytotoxicity and is resistant to photobleaching, making it an ideal choice for visualizing both short and long-term processes. | |||
T2654 |
GSK2656157
|
Apoptosis; PERK; Autophagy | Apoptosis; Autophagy |
GSK2656157 是一种ATP 竞争性的PERK 选择性抑制剂,IC50值为 0.9 nM。 | |||
T2614 |
GSK2606414
|
Apoptosis; PERK; Autophagy | Apoptosis; Autophagy |
GSK2606414 是可渗透细胞且有口服活性的蛋白激酶 R 样内质网激酶抑制剂,IC50值为 0.4 nM。 | |||
T8982 |
RH01687
|
Others | Others |
RH01687 是可以保护胰腺 β 细胞免受内质网应激诱导的细胞死亡的化合物。它对糖尿病具有潜在的研究价值。 | |||
T21976 |
ONO-8130
|
Prostaglandin Receptor | GPCR/G Protein; Immunology/Inflammation |
ONO-8130 是前列腺素 EP1 受体选择性拮抗剂,口服有活力,能够阻断 L6 脊髓中ERK 的磷酸化。它可缓解环磷酰胺致膀胱炎小鼠的膀胱疼痛,可用于研究间质性膀胱炎。 | |||
T6183 |
ISRIB (trans-isomer)
ISRIB,ISRIB trans-isomer,trans-isomer,trans-ISRIB |
Apoptosis; PERK; Autophagy | Apoptosis; Autophagy |
ISRIB (trans-isomer) (ISRIB trans-isomer)是一种 PERK 的高效抑制剂,可有效逆转 eIF2α 磷酸化的作用,IC50值为 5 nM。 | |||
T11221 |
ERAP1-IN-1
|
Others | Others |
ERAP1-in-1 是一种内质网氨基肽酶 1 (ERAP1) 抑制剂,能竞争性地抑制 ERAP1 对代表性生物底物九聚物肽的作用。 | |||
T22436 |
Takeda-6d
|
VEGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
Takeda-6d 是一种新型、有效的 DFG-out RAF/血管内皮生长因子受体 2 (VEGFR2) 抑制剂,IC50 分别为 7.0 nM 和 2.2 nM。 | |||
T9110 |
Ceapin-A7
|
Others | Others |
Ceapin-A7 是内质网应激 ATF6α信号的选择性阻断剂(IC50:0.59 μM),可用于探讨 ATF6α 促细胞活化的机制及其在病理环境中的作用。 | |||
T8901 |
YUM70
|
Apoptosis; GPR; HSP | Apoptosis; Cytoskeletal Signaling; Endocrinology/Hormones; GPCR/G Protein; Metabolism |
YUM70 是一种选择性葡萄糖调节蛋白 78 抑制剂,抑制全长蛋白的 GRP78 ATPase 活性的IC50值为 1.5 μM。它在胰腺癌中诱导内质网应激介导的细胞凋亡。 | |||
T9349 |
IXA4
|
IRE1 | Cell Cycle/Checkpoint |
IXA4 是一种高选择性、无毒的 IRE1/XBP1s 激活剂,通过激活 IRE1 来减少 APP 的分泌。它刺激的 IRE1 激活也增强了胰腺功能。 | |||
T13416 |
ZX-29
|
ALK | Angiogenesis; Tyrosine Kinase/Adaptors |
ZX-29 是一种选择性ALK 抑制剂,对ALK、ALK L1196M 和ALK G1202R 的IC50分别为 2.1 nM、1.3 nM 和 3.9 nM。它还可诱导保护性自噬并具有抗肿瘤作用。它通过诱导内质网应激来诱导细胞凋亡,并克服了由ALK 突变引起的细胞抗性。 | |||
T9564 |
IRE1α kinase-IN-1
|
IRE1 | Cell Cycle/Checkpoint |
IRE1α kinase-IN-1 是IRE1α 的选择性抑制剂(IC50为 77 nM),对 IRE1α 的选择性高于 IRE1β 亚型 100 倍。它抑制内质网诱导的 IRE1α 寡聚和自磷酸化,并抑制 IRE1α RNase 活性 (IC50=80 nM)。 | |||
T19663 |
Triheptanoin
UX 007,IND106011,三庚酸甘油脂,UX007,UX-007,IND 106011,IND-106011 |
Others | Others |
Triheptanoin (IND 106011) 是合成的中链甘油三酯 (MCT),由甘油主链上的三个奇数链 7-碳(庚酸)脂肪酸组成,可以用于研究遗传代谢紊乱。 | |||
T0787 |
Butylhydroxyanisole
BHA,丁基羟基茴香醚,丁基大茴香醚,E320,Butylated hydroxyanisole |
Antioxidant; Ferroptosis; Reactive Oxygen Species | Apoptosis; Immunology/Inflammation; Metabolism; NF-κB; oxidation-reduction |
Butylhydroxyanisole (BHA) 是一种抗氧化剂,能介导肝毒性、生殖器官发育和学习迟缓以及睡眠不足,用作食品防腐剂。它也是一种铁死亡诱导剂,能导致大脑和神经发育中断,具有神经毒性。 | |||
T6993 |
Tauroursodeoxycholate sodium
牛磺熊脱氧胆酸钠,Sodium tauroursodeoxycholate,Tauroursodeoxycholic acid sodium salt,TUDC,牛磺熊去氧胆酸钠,Sodium Tauroursodeoxycholate (TUDC) |
Apoptosis; ERK; Caspase | Apoptosis; MAPK; Proteases/Proteasome |
Tauroursodeoxycholate sodium (TUDC) 是一种内质网应激抑制剂。Tauroursodeoxycholate sodium (TUDC) 抑制ERK,显著降低凋亡分子表达,如caspase-3和caspase-12。 | |||
T27579 |
ICL-CCIC-0019
ICL CCIC 0019 |
AChR | Neuroscience |
ICL-CCIC-0019 是胆碱激酶 α (ChoKα) 的抑制剂。 ICL-CCIC-0019 诱导癌细胞系 G1 期阻滞、内质网应激和凋亡。 | |||
T7540 |
2,5-Di-tert-butylhydroquinone
BHQ,2,5-二特丁基对苯二酚 |
Calcium Channel; Lipoxygenase; COX | Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience |
2,5-Di-tert-butylhydroquinone (BHQ) 是一种有效和选择性的内质网 Ca2+-ATPase 抑制剂,可调节5-LO 以及COX-2活性,IC50分别为 1.8 和 14.1 μM。 | |||
T7373 |
CDN1163
|
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
CDN1163 是肌膜/内质网 Ca2+-ATPase (SERCA)的变构激活剂,可改善 Ca2+稳态,可减轻糖尿病和代谢紊乱。 | |||
T16873 |
SERCA2a activator 1
|
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
SERCA2a activator 1 是一种肌肉/内质网 Ca2+ 依赖性 ATPase 2a 激活剂。 SERCA2a activator 1 降低受磷蛋白抑制并增强心脏的收缩和舒张功能。 | |||
T13219 |
TTA-Q6
|
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
TTA-Q6 是一种选择性 T 型 Ca2+ 通道拮抗剂,具有潜在的抗肿瘤和免疫调节活性,可抑制肿瘤细胞摄取细胞外钙离子,诱导细胞内钙缺乏和内质网(ER)应激,用于治疗神经系统疾病。 | |||
T14080 |
AA147
ATF6-activator-147 |
Others | Others |
AA147 (ATF6-activator-147) 是小分子内质网蛋白稳态调节剂,能够选择性激活未折叠蛋白反应的 ATF6臂。 | |||
T6267 |
Lomitapide
AEGR-733,洛美他派,BMS-201038 |
CETP | Metabolism |
Lomitapide (AEGR-733) 是一种高效的微粒体甘油三酯转移蛋白(MTP)抑制剂,体内试验的IC50值为8 nM。 | |||
T61428 |
4-PQBH
|
Others | Others |
4-PQBH 是一种有效的 Nur77 结合剂,具有抗肿瘤活性。4-PQBH通过 Nur77 介导的内质应激和自噬广泛诱导半胱天冬酶非依赖性细胞质空泡化和旁睑下垂,抑制异种移植肿瘤。4-PQBH 可用于研究肝癌。 | |||
T4400 |
DIM-C-pPhOH
CDIM8 |
Apoptosis; Others | Apoptosis; Others |
DIM-C-pPhOH (CDIM8) 是一种核受体 4A1(NR4A1) 拮抗剂,可降低细胞增殖,对 ACHN 细胞和 786-O 细胞的IC50值分别为 13.6 μM 和 13.0 μM。它抑制癌细胞的生长和 mTOR 信号传导,诱导细胞凋亡和细胞应激。 | |||
T16550 |
PKR-IN-C16
|
Others | Others |
PKR-IN-C16 是一种特异性蛋白激酶抑制剂。它能够抑制 PKR 的自磷酸化,解除 PKR 在原代神经元细胞培养中诱导的翻译阻断。 | |||
T6509 |
Galeterone
VN-124-1,TOK-001,VN/124-1,VN 124 |
P450; Androgen Receptor | Endocrinology/Hormones; Metabolism |
Galeterone (VN 124) 是CYP17抑制剂,能够多功能的抗雄激素,在去势抵抗性前列腺癌中,其IC50值为 47 nM。 | |||
T12009 |
Telomerase-IN-1
|
Telomerase | DNA Damage/DNA Repair |
Telomease-IN-1是一种端粒酶抑制剂(IC50:0.19μM)。Telomease-IN-1通过ER 过度反应(EOR)的内质网应激(ERS)激活hTERT 的表达,然后诱导ERS,导致细胞凋亡。Telomease-IN-1通过表达下游信号分子包括CHOP(CAAT /增强子结合蛋白同源蛋白))和线粒体凋亡途径,导致细胞增殖受到抑制。Telomease-IN-1对端粒酶具有较高的抑制活性,对SMMC-7721细胞具有较高的抗增殖能力,对人正常肝细胞无明显毒性作用。Telomease-IN-1 在异种移植肿瘤模型表现出抗肿瘤活性。 | |||
T23709 |
alphaSYN-IN-NAB2
alphaSYN inhibitor NAB2,alphaSYNINNAB2,alphaSYN-IN-NAB2,NAB2,alphaSYN inhibitor-NAB2 |
||
alphaSYN-IN-NAB2 是一种神经元保护剂,是一种由 NAB2基因编码的蛋白质。NAB2 高效且具有选择性地保护多种细胞免受 α-syn 毒性。NAB2 对依赖于 E3 泛素连接酶 Rsp5/Nedd4 的内体转运具有促进作用。NAB2 确定 α-syn 生物学中的一个可活性分子节点,该节点可以纠正其潜在病理学的多个方面,包括功能失调的内体和内质网到高尔基体囊泡的运输。NAB2参与细胞分化、凋亡和应激反应等细胞过程,可用来研究癌症、神经发育和神经元活动。 | |||
T40385 |
Eroonazole
|
||
Eroonazole is a new small molecule disrupter of endoplasmic reticulum structure. | |||
T68268 |
OSL-95II
|
||
OSL-95II is an inhibitor of the glycan-processing enzyme endoplasmic-reticular glucosidase. | |||
T33087 |
Lysyl-aspartyl-glutamyl-leucine
Kdel sequence,Lys-asp-glu-leu |
||
Lysyl-aspartyl-glutamyl-leucine maintains type II surface membrane proteins in the endoplasmic reticulum. | |||
T70516 |
ToP-DNJ
|
||
ToP-DNJ is a selective inhibitor of endoplasmic reticulum α-Glucosidase II, exhibiting antiflaviviral activity. | |||
T15599 |
Istaroxime hydrochloride
PST2744 hydrochloride |
Others | Others |
Istaroxime hydrochloride is an inhibitor of Na+/K+-ATPase (IC50: 0.11 μM). It also is a sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA 2) activator. | |||
T21131 |
NASTRp
Naphthol AS-TR phosphate |
||
NASTRp, an inhibitor of CREB-CBP complex, possesses anti-cancer effects along with cell cycle regulation, autophagy suppression, and endoplasmic reticulum stress. | |||
T19182 |
Afegostat D-Tartrate
Isofagomine D-Tartrate,D-Isofagomine D-Tartrate |
Others | Others |
Afegostat D-Tartrate is a pharmacological chaperone that specifically and reversibly binds acid-β-glucosidase (GCase) in the endoplasmic reticulum with high affinity. | |||
T16998 |
Tauroursodeoxycholate dihydrate
牛磺熊去氧胆酸二水合物,Taurolite dihydrate,TUDCA dihydrate,UR 906 dihydrate |
ERK; Caspase | Apoptosis; MAPK; Proteases/Proteasome |
Tauroursodeoxycholate dihydrate is an endoplasmic reticulum stress inhibitor. Tauroursodeoxycholate also inhibits ERK. Tauroursodeoxycholate significantly decreases the expression of apoptosis molecules, such as caspase-3 and caspase-12. | |||
T32082 |
Histidyl-aspartyl-glutamyl-leucine
His-asp-glu-leu,Hdel sequence |
||
HDEL intracellular distribution is characteristic of plant endoplasmic reticulum (ER). | |||
T19266 |
Ins(1,4,5)-P3 hexapotassium salt
1,4,5-IP3 hexapotassium salt,D-myo-Inositol 1,4,5-trisphosphate hexapotassium salt |
Others | Others |
D-myo-Inositol 1,4,5-trisphosphate hexapotassium salt is promotes endoplasmic The second messenger of net calcium ions. | |||
T31670 |
ER-thermo-Yellow
ER thermo Yellow |
||
ER-thermo-Yellow is the first fluorescent probe for targeted visualization of temperature at the endoplasmic reticulum with the highest sensitivity reported so far (3.9%/°C). | |||
T15218 | EN460 | Others | Others |
EN460 is an inhibitor of endoplasmic reticulum oxidation 1 (ERO1) and interacts selectively (IC50: 1.9 uM) with the reduced, active form of ERO1α and prevents its reoxidation. | |||
T34601 |
Sekdel sequence
Ser-glu-lys-asp-glu-leu |
||
Sekdel sequence, as a signal, leads to retention of at least two proteins in the endoplasmic reticulum of animal cells. | |||
T73536 | QM295 | ||
QM295, 内质网氧化 1(ERO1)的选择性可逆硫醇反应性抑制剂,适用于研究内质网应激。 | |||
T27756 |
KUNG94
KUNG 94,KUNG-94 |
||
KUNG94 is a potent and selective inhibitor of Glucose regulated protein 94 (Grp94) (IC50 = 8 nM), the endoplasmic reticulum resident of the 90 kDa heat shock protein (Hsp90) family. | |||
T19181 |
Afegostat
D-Isofagomine,Isofagomine |
Others | Others |
Afegostat is a pharmacological chaperone that specifically and reversibly binds acid-β-glucosidase (GCase) in the endoplasmic reticulum with high affinity. | |||
T24693 |
QD325
QD 325,QD-325 |
||
QD325 is a potent redox modulator for the Treatment of Pancreatic Ductal Adenocarcinoma. Nascent RNA sequencing following treatments with QD325 revealed induction of stress responses in the nucleus, endoplasmic reticulum, and mitochondria of pancreatic ca | |||
T73096 |
Z-LEVD-FMK
|
||
Z-LEVD-FMK 是一种细胞渗透性的caspase-4抑制剂。 Z-LEVD-FMK 阻断 ER 应激诱导的癌细胞凋亡。 | |||
T15554 | IHVR-19029 | Others | Others |
IHVR-19029 is an effective endoplasmic reticulum (ER) α-glucosidases I and II inhibitor (IC50: 0.48 μM for ER a-glucosidase I). IHVR-19029 efficiently blocks the replication of several hemorrhagic fever viruses, such as Ebola virus, Dengue virus, and Rift | |||
T39264 |
Cyclotriazadisulfonamide
CADA,Cyclotriazadisulfonamide |
||
Cyclotriazadisulfonamide (CADA) is a specific inhibitor of HIV entry that targets CD4. It functions by preventing the co-translational translocation of human CD4 (huCD4) into the endoplasmic reticulum (ER) lumen through a mechanism dependent on the signal peptide (SP). | |||
T36812 |
Linoleic Acid Amide
9,12-Octadecadienamide,Linoleamide,Linoleic Acid Amide |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Linoleic Acid Amide (Linoleamide) 衍生自亚油酸,通过抑制肌肉/内质网 Ca2+-ATP 酶来调节 Ca2+ 通量。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T5A2461 |
Bufotalin
蟾蜍他灵,Bufotaline,蟾毒它灵,蟾蜍他灵 |
Apoptosis; Others; Reactive Oxygen Species | Apoptosis; Immunology/Inflammation; Metabolism; NF-κB; Others |
Bufotalin (Bufotaline) 是一种从蟾酥中分离的类固醇内酯,可诱导癌细胞凋亡,也诱导内质网应激的激活,具有强大的抗肿瘤活性。 | |||
T2532 |
Tauroursodeoxycholate
Taurolite,牛磺熊去氧胆酸,Tauroursodeoxycholic Acid,UR 906,Ursodeoxycholyltaurine,TUDCA |
Apoptosis; ERK; P450; Caspase; Endogenous Metabolite | Apoptosis; MAPK; Metabolism; Proteases/Proteasome |
Tauroursodeoxycholate (UR 906),又称 ursodoxicoltaurine,是一种高度亲水性的三级胆汁酸,在人体内以低浓度产生。Tauroursodeoxycholate 是 ursodeoxycholic acid 更亲水的形式,而 ursodeoxycholic acid 是人类体内自然产生的更丰富的胆汁酸。Tauroursodeoxycholate 正在研究用于几种疾病,如原发性胆汁性肝硬化(PBC)、胰岛素抵抗、淀粉样变性、囊性纤维化、胆汁淤滞和肌萎缩性侧索硬化症。 | |||
T22468 |
1-Deoxymannojirimycin hydrochloride
|
Others; Influenza Virus; HIV Protease | Microbiology/Virology; Others; Proteases/Proteasome |
1-Deoxymannojirimycin hydrochloride 是一种选择性的 α1,2-甘露糖苷酶抑制剂,IC50值为 20 μM。它还抑制 HIV-1 毒株,抗病毒活性较差。 | |||
T0200 |
α-Lipoic Acid
Thioctic acid,DL-α-Lipoic acid,(±)-α-Lipoic acid,α-硫辛酸,硫辛酸 |
Apoptosis; NF-κB; HIV Protease; Mitochondrial Metabolism; Endogenous Metabolite | Apoptosis; Metabolism; Microbiology/Virology; NF-κB; Proteases/Proteasome |
α-Lipoic Acid (DL-α-Lipoic acid) 是线粒体酶复合物的重要辅助因子,是一种抗氧化剂,可抑制NF-κB 依赖性的HIV-1LTR 活化。它还可诱导内质网应激介导的肝癌细胞凋亡。 | |||
TQ0302 |
Thapsigargin
毒胡萝卜素 |
Apoptosis; SARS-CoV; Calcium Channel | Apoptosis; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology |
Thapsigargin 属于天然产物,是一种肌/内质网 Ca2+ ATP 酶 (SERCA) 的抑制剂,也是一种内质网应激诱导剂。Thapsigargin 通过阻断细胞将钙泵入肌浆和内质网的能力来提高胞浆钙浓度。 | |||
T15027 |
Cyclopiazonic acid
环匹阿尼酸,环二氮酸 |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Cyclopiazonic acid 是一种神经毒性次级代谢产物 (SM),源于A. flavus,是一种纳摩尔内质网钙 ATP 酶抑制剂 (Ca2+ATPase; SERCA),是植物细胞死亡的有效诱导剂。 | |||
TN1560 |
Dehydroeffusol
去氢厄弗酚,5-Ethenyl-1-Methylphenanthrene-2,7-Diol,Dehydro Effusol |
MMP; ERK; GPR; Others | Endocrinology/Hormones; GPCR/G Protein; MAPK; Others; Proteases/Proteasome |
Dehydroeffusol (Dehydro Effusol) 通过选择性诱导肿瘤抑制性内质网应激和中度细胞凋亡来抑制胃癌细胞生长和致瘤性,具有抗癌、抗焦虑和镇静作用。 | |||
T2930 |
α-Lipoic Acid
Lipoic acid,Alphalipoic acid,硫辛酸 |
NF-κB; HIV Protease; Mitochondrial Metabolism; Endogenous Metabolite | Metabolism; Microbiology/Virology; NF-κB; Proteases/Proteasome |
α-Lipoic Acid (Alphalipoic acid) 抑制 NF-κB 依赖性 HIV-1 LTR 活化。 α-硫辛酸诱导内质网 (ER) 应激介导的肝癌细胞凋亡。α-硫辛酸是一种抗氧化剂,是线粒体酶复合物的重要辅助因子。 | |||
T5S2343 |
Acetylshikonin
乙酰紫草素,Acetyl shikonin |
Others; P450; AChE | Metabolism; Neuroscience; Others |
Acetylshikonin 来源于紫草根,具有抗癌、抗炎作用。它是一种 AChE 抑制剂,具有很强的抗凋亡活性。它是一种非选择性的细胞色素 P450抑制剂,对所有 P450 亚型抑制的 IC50值范围为 1.4-4.0 μM。 | |||
T11363 |
Ganoderic acid F
|
Others | Others |
Ganoderic acid F 是一种灵芝酸。它具有抗肿瘤和抗转移的活性,与抑制血管生成和涉及细胞增殖和细胞死亡,致癌作用,氧化应激,钙信号传导和内质网应激的蛋白质改变等机制相关。 | |||
T4395 |
Daphylloside
|
Others | Others |
Daphylloside, and asperuloside can be suggested as endoplasmic reticulum stress regulators. | |||
T13430 |
ABTL-0812
α-羟基油酸,α-Hydroxylinoleic acid |
Others | Others |
ABTL-0812 induces endoplasmic reticulum (ER) stress-mediated autophagy, and with anti-cancer activity. | |||
T19253 |
Cyclic ADP-ribose
cADPR |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Cyclic ADP-ribose (cADPR) is an effective calcium mobilization second messenger, which is synthesized from NAD + by ADP-ribosyl cyclase. Cyclic ADP-ribose mainly increases cytosolic calcium through Ryanodine receptor-mediated endoplasmic reticulum release | |||
TN1645 |
Flavokawain C
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NADPH-oxidase; MAPK; AChR | Immunology/Inflammation; MAPK; Neuroscience |
Flavokawain C is a melanogenesis inhibitor, it inhibited melanogenesis with IC50 values of 6.9 μM. Flavokawain C has anti-tumor activity, it inhibited cell cycle and promoted apoptosis, associated with endoplasmic reticulum stress and regulation of MAPKs and Akt signaling pathways in HCT 116 human colon carcinoma cells. | |||
T37687 | Cyclic ADP-ribose ammonium | ||
Cyclic ADP-ribose ammonium (cADPR ammonium) is a powerful calcium mobilization second messenger synthesized from NAD+ by an ADP-ribosyl cyclase. It primarily raises cytosolic calcium levels through Ryanodine receptor-mediated release from the endoplasmic reticulum, while also facilitating extracellular influx through the opening of TRPM2 channels [1][2][3]. | |||
TN5440 |
Catechin-7-O-xyloside
Catechin 7-O-β-D-xylopyranoside |
Others | Others |
Catechin-7-O-xyloside(C7Ox)具有抗癌活性,它通过内质网应激和线粒体功能障碍诱导人非小细胞肺癌H1299细胞凋亡。 | |||
TN3719 |
Cristacarpin
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p38 MAPK; ROS; CDK; Antifection; p53 | Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation; MAPK; Microbiology/Virology |
Cristacarpin exhibits moderate but selective activity towards DNA repair-deficient yeast mutants. It promotes endoplasmic reticulum (ER) stress, leading to sub-lethal reactive oxygen species (ROS) generation and which eventually terminates by triggering s | |||
T75637 | Demethylcantharidate disodium | ||
Demethylcantharidate disodium 是一种内源性代谢产物,能通过诱导内质网应激来促进肝癌细胞的凋亡,并且对多种类型的癌症展现出良好的抗癌活性。 | |||
T39605 |
β-D-Glucopyranosyl abscisate
ABA-GE,β-D-Glucopyranosyl abscisate,(S)-cis,trans-Abscisicacidglucosylester |
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β-D-Glucopyranosyl abscisate (ABA-GE) is a hydrolyzable conjugate of abscisic acid (ABA), which predominantly accumulates in the vacuole and likely in the endoplasmic reticulum. The deconjugation of β-D-Glucopyranosyl abscisate enables a swift release of free ABA in response to abiotic stress factors like dehydration and salt stress. β-D-Glucopyranosyl abscisate plays a crucial role in maintaining ABA homeostasis. | |||
T82753 | Celangulin | ||
Celangulin是一种从Celastrus angulatus中提取的天然杀虫成分,该化合物通过激活细胞质膜上的钙通道来增加细胞内Ca2+浓度,并能激活内质网钙通道。 | |||
T72429 |
α-Lipoic Acid sodium
Thioctic acid sodium,DL-α-Lipoic acid sodium,Thioctic acid sodium ; (±)-α-Lipoic acid sodium ; DL-α-Lipoic acid sodium,(±)-α-Lipoic acid sodium |
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α-Lipoic Acid (Thioctic acid) sodium 是一种抗氧化剂,是线粒体酶复合物的重要辅助因子。α-Lipoic Acid sodium 可抑制NF-κB 依赖性的HIV-1LTR 活化。α-Lipoic Acid sodium 诱导内质网应激 (ERS) 介导的肝癌细胞凋亡 (apoptosis)。α-Lipoic Acid sodium 可与CPUL1 合成自组装的纳米聚合体 CPUL1-LA NA,其抗肿瘤效果优于 CPUL1。 | |||
T75540 |
Ipomoeassin F
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Ipomoeassin F 是一种高效且具有选择性的内质网(ER)蛋白转位抑制剂,它通过作用于ER膜上的Sec61复合物(Sec61α)的成孔亚基来实现其功能。此化合物能特异性抑制SARS-CoV-2蛋白在ER膜上的转位,同时阻碍分泌蛋白和I型跨膜蛋白(TMP)的ER转运,但对III型TMP的转运不产生影响。 | |||
T35577 |
Phosphatidylserines (bovine)
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Phosphatidylserine is a naturally occurring phospholipid that comprises 2-10% of total phospholipids in mammals and is enriched in the central nervous system, particularly the retina. It is anionic and found mainly on the inner leaflet of the cell membrane. It is biosynthesized from phosphatidylcholine or phosphatidylethanolamine by phosphatidyl synthase 1 (PSS1) or PSS2, respectively, in the endoplasmic reticulum and can be reversibly converted back by the same enzymes. It can also be irreversi... |