Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Istaroxime hydrochloride is an inhibitor of Na+/K+-ATPase (IC50: 0.11 μM). It also is a sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA 2) activator.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
2 mg | ¥ 1,060 | 5日内发货 | ||
5 mg | ¥ 1,790 | 5日内发货 | ||
25 mg | ¥ 5,930 | 6-8周 | ||
50 mg | ¥ 7,710 | 6-8周 | ||
100 mg | ¥ 11,600 | 6-8周 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,560 | 5日内发货 |
产品描述 | Istaroxime hydrochloride is an inhibitor of Na+/K+-ATPase (IC50: 0.11 μM). It also is a sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA 2) activator. |
靶点活性 | Na+, K+-ATPase:0.11 μM |
体外活性 | Istaroxime (PST2744) inhibits the Na+/K+-ATPase activity from dog kidney (IC50: 0.43 ± 0.15 μM). Istaroxime hydrochloride acting as a positive inotropic compound through the inhibition of the Na+,K+-ATPase[2]. Inhibition of Na+/K+-ATPase activity in preparations from guinea pig kidney yielded potencies of 8.5 μM for PST2744[3]. |
体内活性 | Istaroxime (PST2744) causes a progressive to enhance in +dP/dtmax throughout the infusion. That reaches 80% (ED80) at the cumulative dose of 1.89±0.37 mg/kg and a peak of 140±3.5% at the dose (EDmax) of 4.88±0.6 mg/kg[3]. |
别名 | PST2744 hydrochloride |
分子量 | 396.96 |
分子式 | C21H33ClN2O3 |
CAS No. | 374559-48-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45 mg/mL (113.36 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.5191 mL | 12.5957 mL | 25.1915 mL | 62.9786 mL |
5 mM | 0.5038 mL | 2.5191 mL | 5.0383 mL | 12.5957 mL | |
10 mM | 0.2519 mL | 1.2596 mL | 2.5191 mL | 6.2979 mL | |
20 mM | 0.126 mL | 0.6298 mL | 1.2596 mL | 3.1489 mL | |
50 mM | 0.0504 mL | 0.2519 mL | 0.5038 mL | 1.2596 mL | |
100 mM | 0.0252 mL | 0.126 mL | 0.2519 mL | 0.6298 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Istaroxime hydrochloride 374559-48-5 Others PST 2744 Hydrochloride PST-2744 Hydrochloride Istaroxime Hydrochloride PST2744 Hydrochloride PST2744 hydrochloride Inhibitor inhibitor inhibit