Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ONO-8130 是前列腺素 EP1 受体选择性拮抗剂,口服有活力,能够阻断 L6 脊髓中ERK 的磷酸化。它可缓解环磷酰胺致膀胱炎小鼠的膀胱疼痛,可用于研究间质性膀胱炎。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 1,560 | 现货 | ||
5 mg | ¥ 3,480 | 现货 | ||
10 mg | ¥ 4,950 | 现货 | ||
25 mg | ¥ 7,880 | 现货 | ||
50 mg | ¥ 10,600 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 4,470 | 现货 |
产品描述 | ONO-8130 is an orally available antagonist of EP1 receptor. |
体内活性 | Oral preadministration of ONO-8130 at 0.3-30 mg/kg strongly prevented both the bladder pain-like behavior and referred hyperalgesia in a dose-dependent manner, but had slight effect on the increased bladder weight and vascular permeability.?Oral ONO-8130 at 30 mg/kg also reversed the established cystitis-related bladder pain.?Intravesical administration of prostaglandin E2 caused prompt phosphorylation of ERK in the L6 spinal cord, an effect blocked by ONO-8130.?The prostaglandin E2/EP1 system participates in processing of cystitis-related bladder pain, and that EP1 antagonists including ONO-8130 are useful for treatment of bladder pain, particularly in interstitial cystitis.?Prostaglandin E2 contributes to cystitis-related bladder pain via EP1 receptors in mice, indicating possible therapeutic usefulness of selective EP1 antagonists[1]. |
分子量 | 500.63 |
分子式 | C25H28N2O5S2 |
CAS No. | 459841-96-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 5 mg/mL (10 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.9975 mL | 9.9874 mL | 19.9748 mL | 49.9371 mL |
5 mM | 0.3995 mL | 1.9975 mL | 3.995 mL | 9.9874 mL | |
10 mM | 0.1997 mL | 0.9987 mL | 1.9975 mL | 4.9937 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
ONO-8130 459841-96-4 GPCR/G Protein Immunology/Inflammation Prostaglandin Receptor Orally active Inhibitor inhibit Bladder pain Interstitial cystitis PKR-like endoplasmic reticulum kinase PERK Hyperalgesia Protein kinase R-like endoplasmic reticulum kinase ONO8130 ONO 8130 inhibitor