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47

抑制剂 & 化合物

24

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T22223	3PO	Glucokinase; Autophagy	Autophagy; Metabolism
	3PO 是一种 PFKFB3 的小分子抑制剂，IC50值为22.9 μM。它抑制几种人类恶性造血和腺癌细胞系的增殖，IC50在1.4到24 μM 之间。它抑制葡萄糖摄取，并降低 Fru-2,6-BP、乳酸、ATP、NAD+ 和 NADH 的细胞内浓度。
T20137	Dimethoate Rogor,Phosphamid,Lurgo,L395,乐果,L 395,L-395	Others	Others
	Dimethoate (L-395) 是一种系统性和接触性杀虫剂，用于控制牛蛴螬和农场动物的某些其他害虫。
T21435	Sulfamoxole 磺胺二甲唑,NSC 683535,Oxasulfa,Sulfamoxol,NSC683535,Oxazole,NSC-683535	Antibacterial	Microbiology/Virology
	Sulfamoxole (Sulfamoxol) 是一种广谱化疗抗菌剂，可用于小儿感染的相关研究。
T16045	Methotrexate metabolite DAMPA,甲喋呤杂质E	Antifolate; Drug Metabolite	Cell Cycle/Checkpoint; Metabolism
	Methotrexate metabolite (DAMPA) (DAMPA)是 Methotrexate 的活性代谢物。Methotrexate 具有拮抗叶酸 (folic acid) 的作用，被用作免疫抑制剂。
T1892	Kobe2602	Raf; Ras	GPCR/G Protein; MAPK
	Kobe2602 是 Ras-Raf 相互作用抑制剂，具有抗癌化疗活性。它抑制 H-Ras·GTP 与 c-Raf-1 RBD 结合的Ki 值为 149 μM。
T11373	GCN2-IN-1 A-92	Others	Others
	GCN2-IN-1 (A-92) 是一种有效的一般性调控阻遏蛋白激酶 2 抑制剂，可作为化疗药物用于癌症治疗的研究。
T16349	NSC-60339	Others; Antibacterial	Microbiology/Virology; Others
	NSC-60339 是一种外排泵抑制剂和 AcrAB-TolC 的底物，是聚对苯二甲酸衍生物，对癌症化疗有潜在作用。
T2158	Nutlin-3 Nutlin3	E1/E2/E3 Enzyme	Ubiquitination
	Nutlin-3 是一种 MDM2 拮抗剂，抑制 MDM2-p53 相互作用，Ki 为 90 nM，并激活 p53。
T0951	Hydroxychloroquine sulfate Acidum iopanoicum,硫酸羟基氯喹,硫酸羟氯喹,HCQ sulfate	DNA; SARS-CoV; TLR; Parasite; Autophagy	Autophagy; DNA Damage/DNA Repair; Immunology/Inflammation; Microbiology/Virology
	Hydroxychloroquine sulfate (Acidum iopanoicum) 抑制疟原虫血红素聚合酶。它还可抑制 Toll 样受体 7/9 信号传导和 SARS-CoV-2 感染。
TP1792L	KKI-5 acetate(97145-43-2 free base)	Serine Protease	Proteases/Proteasome
	KKI-5 acetate(97145-43-2 free base) 是一种丝氨酸蛋白酶抑制剂，可抑制激肽释放酶和纤溶酶。 KKI 5 可能表现出抗癌化疗益处，也可用作血管性水肿的治疗方法。
T8979	AEM1	Nrf2	Immunology/Inflammation
	AEM1 是 Nrf2抑制剂，能够降低 A549 细胞中 Nrf2 依赖基因的表达，并在体外和体内抑制 A549 细胞的生长。
T72024	ZIM
	ZIM，一种从4-Aminoantipyrine衍生的降冰片烯，有效诱导DNA损伤，造成基因组及染色体损害，进而引发细胞死亡和激活吞噬。其化疗潜力适用于癌症研究。
T15771	Lobaplatin D-19466,络铂	DNA Alkylation	DNA Damage/DNA Repair
	Lobaplatin (D-19466) 是一种铂 (II) 复合物的非对映混合物，是一种有前途的抗肿瘤化疗药物，在多种肿瘤类型的患者中具有活性。
T26911	Bromotetrandrine 5-Bromotetrandrine,W-198,BrTet,W 198,W198
	Bromotetrandrine is an P-glycoprotein inhibitor, which were developed and coadministered with chemotherapeutic drugs to overcome the effect of efflux pumps thus enhancing the chemosensitivity of therapeutics.
T31918	GCNU NSC 114460,NSC114460,NSC-114460
	GCNU has chemotherapeutic effects on the LSA lymphoma ascites tumor.
TP1792	KKI-5
	KKI 5 is a serine protease inhibitor that inhibits kallikrein and plasmin. KKI 5 may exhibit anticancer chemotherapeutic benefit and may also be used as a treatment for angioedema.
T25021	Alafosfalin Alaphosphin
	Alafosfalin is a Chemotherapeutic agent.
T33872	Pam 1392 AI3 52841,AI352841,AI3-52841
	Pam 1392 is a chemotherapeutic agent.
T34841	Thiacetarsamide
	Thiacetarsamide is a proposed chemotherapeutic agent against filaria and trichomonas.
T25723	L-Ifosfamide (+)-Ifosfamide
	L-Ifosfamide is nitrogen mustard, a chemotherapeutic antineoplastic, and more precisely an alkylating agent structural analog of cyclophosphamide with respect to which presents some differences regard to the antitumor activity and spectrum.
T27217	Duazomycin Duazomycin A,Acetyl-don,Diazomycin A,NSC 51097
	Duazomycin, an antitumor substance and glutamine antagonist, is used as a chemotherapeutic agent.
T38679	DODAP
	DODAP, an ionizable cationic lipid, serves as a vital component in liposome formation. Its applications encompass the capability to encapsulate siRNA, immunostimulatory chemotherapeutic agents for in vitro and in vivo delivery, among others.
T68781	3Ac-SL0101
	3Ac-SL0101 is a potent RSK-specific inhibitor. It facilitates the development of RSK inhibitors as anti-cancer chemotherapeutic agents.
T69005	CEP-6800
	CEP-6800 is a potent PARP inhibitor with potential anticancer activity. CEP-6800 could be used as a chemopotentiating agent with a variety of clinically effective chemotherapeutic agents.
T61033	S07-2001
	S07-2001 增强Doxorubicin 抗癌细胞的活性，可作为耐药癌症的化疗增强剂。S07-2001 是有效的醛酮还原酶 1C3 (AKR1C3)的选择性抑制剂，IC50值为 2.08 μM。
T15180	Duocarmycin A	Caspase	Apoptosis; Proteases/Proteasome
	Duocarmycin A, an antitumor antibiotic, is a DNA alkylator and efficiently alkylates adenine N3 at the 3′ end of AT-rich sequences in the DNA. Duocarmycin A, as a chemotherapeutic agent, results in HLC-2 cells typically apoptotic changes.
T31215	DB-766 DB766
	DB-766 is a potential chemotherapeutic candidate for Chagas' disease treatment. DB-766 exhibits strong trypanocidal activity and excellent selectivity for bloodstream trypomastigotes and intracellular amastigotes (Y strain), giving IC(50)s of 60 and 25 nM
T69162	Ki23057
	Ki23057 is a a FGFR2 inhibitor, which enhances the chemosensitivity of drug-resistant gastric cancer cell lines when used in combination with chemotherapeutic drugs. Ki23057 might be therapeutically promising for treating drug-resistant gastric cancer cells, especially when used in combination with SN38, PTX, or VP16. The apoptosis process might be the main mechanism underlying the synergistic effect of these combinations. The ERCC1 and p53 genes may play an integral role in the synergism betwee...
T18278	Mal-PEG2-VCP-Eribulin	Others	Others
	Mal-PEG2-VCP-Eribulin is a chemotherapeutic compound comprising an antibody-drug conjugate (ADC) linker (Mal-PEG2-VCP) and the microtubule inhibitor Eribulin[1]. This compound uniquely targets microtubules, offering a novel approach to cancer treatment. Eribulin is specifically utilized in creating targeted Eribulin-based drugs for antibody conjugates[1].
T38607	Etoposide phosphate disodium BMY-40481 disodium,Etoposide phosphate disodium
	Etoposide phosphate disodium (BMY-40481 disodium), a phosphate ester prodrug of etoposide, functions as a potent chemotherapeutic agent by selectively inhibiting topoisomerase II, hindering the re-ligation of DNA strands. It is regarded as the active equivalent of etoposide, effectively inducing cell cycle arrest, apoptosis, and autophagy in cancer cells.
T77855	Mal-PEG8-Val-Ala-PAB-Exatecan
	Mal-PEG8-Val-Ala-PAB-Exatecan（化合物9b）是一种用于连接抗体与Nectin-4多肽结合的化疗活性分子的ADC linker，适用于癌症研究。
T71011	Perfluorinated SAHA
	Perfluorinated SAHA is an HDAC inhibitor for use in cancer treatment regimens, with demonstrated greater antiproliferative properties than SAHA . PFSAHA has also been shown to have higher selectivity for PA3774, an HDAC-like enzyme from P. aeruginosa, as well as other HDACs, which may prove beneficial for developing novel chemotherapeutic treatments for cancer.
T69993	BIM-46068
	BIM-46068 is a potent and specific inhibitor of human farnesyltransferase. In regard to a panel of cell lines, using the Compare analysis to determine the Pearson coefficient correlation, the anti-proliferative spectrum of BIM-46068 has been shown to be distinct from the profile of typical chemotherapeutic agents.
T36470	Biotinyl hexylamine
	Biotinyl hexylamine is a synthetic intermediate.1,2It has been used in the synthesis of avidin nucleic acid nano assemblies (ANANAS) and chemotherapeutic conjugates for the diagnosis of, and drug delivery to, tumors. 1.Sabatino, G., Chinol, M., Paganelli, G., et al.A new biotin derivative-DOTA conjugate as a candidate for pretargeted diagnosis and therapy of tumorsJ. Med. Chem.46(14)3170-3173(2003) 2.Bigini, P., Previdi, S., Casarin, E., et al.In vivo fate of avidin-nucleic acid nanoassemblies a...
T61511	S07-2005 (racemic)
	S07-2005 racemic is a chemically potent and selective inhibitor of aldo-keto reductase 1C3 (AKR1C3), with an IC50 value of 0.13 μM and 0.75 μM for AKR1C3 and AKR1C4, respectively. Due to its inhibitory properties, it exhibits potential as a chemotherapeutic potentiator, specifically in the context of overcoming drug resistance in cancer [1].
T61485	S07-2010
	S07-2010 is a potent pan-AKR1C inhibitor, effectively inhibiting AKR1C3, AKR1C4, AKR1C1, and AKR1C2 with IC50 values of 0.19, 0.36, 0.47, and 0.73 μM, respectively. This compound induces apoptosis in A549/DDP cells and enhances the cytotoxicity of chemotherapeutic agents in drug-resistant cells, making it a viable option for combating drug resistance. Furthermore, S07-2010 significantly inhibits the proliferation of drug-resistant cells [1].
T38946	C8 Dihydroceramide C8 Dihydroceramide
	C8 Dihydroceramide acts as a negative control for C8 Ceramide, a cell-permeable analog of natural ceramides. C8 Ceramide, also known as N-Octanoyl-D-erythro-sphingosine, exhibits potent chemotherapeutic properties and anti-proliferation effects. Additionally, it stimulates dendritic cells to enhance T cell responses during viral infections. In vitro studies have also shown that C8 Ceramide induces a slight activation of protein kinase (PKC) [4].
T35439	(E)-5-(2-Bromovinyl)uracil
	(E)-5-(2-Bromovinyl)uracil (BVU) is a pyrimidine base and an inactive metabolite of the antiviral agents sorivudine and (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) that may be regenerated to BVDU in vivo. BVU irreversibly inactivates dihydropyrimidine dehydrogenase (DPD) in an NADPH-dependent manner. It enhances the efficacy of the chemotherapeutic agent and DPD substrate 5-fluorouracil in a P388 murine leukemia model when administered at a dose of 200 μmol/kg, increasing survival time.
T72522	Aurora kinase-IN-1
	Aurora kinase-IN-1 是aurora kinase 的有效抑制剂。Aurora kinase-IN-1 上调 G1 细胞周期抑制蛋白 (包括 p21 和 p27) 以及 G1 进行性细胞周期蛋白 D1 的表达，并下调 G1-to-S 进行性细胞周期蛋白，导致细胞周期停滞在 G1/S 边界。Aurora 激酶-IN-1 还诱导细胞凋亡 (apoptosis）。Aurora 激酶-IN-1 是化疗药物的先导化合物。
T36385	Ansatrienin A
	Ansatrienin A is an ansamycin antibiotic and antifungal agent first isolated from S. collinus and S. rishiriensis. In fetal rat long bones, it is an inhibitor of parathyroid hormone-induced calcium release (IC50 = 64 nM), which is a measure of bone resorption, and pp60c-srcM kinase (IC50 = 100 nM). It also inhibits TNF-α-induced expression of intercellular adhesion molecule-1 (ICAM-1; IC50 = 570 nM). Early in vitro studies showed that ansatrienin A potentiates the chemotherapeutic action of 5-fl...
T74691	Aprinocarsen sodium
	Aprinocarsen (ISIS 3521) sodium，是针对蛋白激酶C-α（PKC-α）的特异性反义寡核苷酸抑制剂，为一种20-mer寡核苷酸，通过调节细胞分化和增殖来发挥作用。其能有效抑制人类肿瘤细胞系在裸鼠体内的生长，展示了作为人类癌症化疗化合物的潜力。
T78841	Nrf2-IN-3
	Nrf2-IN-3 (Compound R16) 为Nrf2抑制剂，与KEAP1突变体 (G333C mKEAP1) 结合，能够恢复受损的KEAP1/NRF2相互作用。该化合物通过修复mKEAP1/NRF2复合物，增加KEAP1突变癌细胞对Cisplatin和Gefitinib的敏感性。
T36650	Ansatrienin B
	Ansatrienin B is an ansamycin antibiotic and antifungal agent first isolated from S. collinus and S. rishiriensis., In fetal rat long bones, it is an inhibitor of parathyroid hormone-induced calcium release (IC50 = 21 nM), which is a measure of bone resorption, and pp60c-src kinase (IC50 = 50 nM). It is an inhibitor of translation at the protein synthesis stage by specific inhibition of L-leucine incorporation (IC50 = 58 nM in A549 cells). It also inhibits TNF-α-induced expression of intercellul...
T38503	(2-pyridyldithio)-PEG1-hydrazine (2-pyridyldithio)-PEG1-hydrazine
	(2-Pyridyldithio)-PEG1-hydrazine is a one-unit cleavable polyethylene glycol (PEG) linker specifically designed for the synthesis of antibody-drug conjugates (ADCs). This linker offers the advantage of controlled release of the drug payload from the ADC construct. It is utilized in the conjugation process between the antibody and the cytotoxic drug, enabling the targeted delivery of the drug to cancer cells. The (2-pyridyldithio) group of this linker provides stability during circulation in the ...
T71279	BPR1K653
	BPR1K653 is a potent Aurora kinase inhibitor with potential anticancder activity. BPR1K653 specifically inhibited the activity of Aurora-A and Aurora-B kinase at low nano-molar concentrations in vitro. BPR1K653 was potent in targeting a variety of cancer cell lines regardless of the tissue origin, p53 status, or expression of MDR1. At the cellular level, BPR1K653 induced endo-replication and subsequent apoptosis in both MDR1-negative and MDR1-positive cancer cells. Importantly, it showed potent ...
T36195	CAY10744
	CAY10744 is a topoisomerase II-α poison.1 It inhibits topoisomerase II-α by 78.9% when used at a concentration of 20 μM. CAY10744 is selective for topoisomerase II-α over topoisomerase I providing 100 and 0% inhibition, respectively, at 100 μM. It inhibits proliferation of HCT15 colon, T47D breast, DU145 prostate, and HeLa cervical cancer cells (IC50s = 0.014, 0.00267, 0.072, and 2.46 μM, respectively). CAY10744 induces apoptosis in T47D cells when used at concentrations of 10 and 30 μM. CAY1074...
T35683	2-deoxy-D-Glucose-13C6 2-deoxy-D-Glucose-13C6
	2-deoxy-D-Glucose-13C6is intended for use as an internal standard for the quantification of 2-deoxy-D-glucose by GC- or LC-MS. 2-deoxy-D-Glucose is a glucose antimetabolite and an inhibitor of glycolysis.1,2It inhibits hexokinase, the enzyme that converts glucose to glucose-6-phosphate, as well as phosphoglucose isomerase, the enzyme that converts glucose-6-phosphate to fructose-6-phosphate.32-deoxy-D-Glucose (16 mM) induces apoptosis in SK-BR-3 cells, as well as inhibits the growth of 143B oste...

化合物

Cat.No: T22223

Target: Glucokinase, Autophagy

Cat.No: T20137

Synonym: Rogor,Phosphamid,Lurgo,L395,乐果,L 395,L-395

Target: Others

Cat.No: T21435

Synonym: 磺胺二甲唑,NSC 683535,Oxasulfa,Sulfamoxol,NSC683535,Oxazole,NSC-683535

Target: Antibacterial

Methotrexate metabolite

Cat.No: T16045

Synonym: DAMPA,甲喋呤杂质E

Target: Antifolate, Drug Metabolite

Cat.No: T1892

Target: Raf, Ras

Cat.No: T11373

Synonym: A-92

Target: Others

Cat.No: T16349

Target: Others, Antibacterial

Cat.No: T2158

Synonym: Nutlin3

Target: E1/E2/E3 Enzyme

Hydroxychloroquine sulfate

Cat.No: T0951

Synonym: Acidum iopanoicum,硫酸羟基氯喹,硫酸羟氯喹,HCQ sulfate

Target: DNA, SARS-CoV, TLR, Parasite, Autophagy

KKI-5 acetate(97145-43-2 free base)

Cat.No: TP1792L

Target: Serine Protease

Cat.No: T8979

Target: Nrf2

Cat.No: T72024

Cat.No: T15771

Synonym: D-19466,络铂

Target: DNA Alkylation

Bromotetrandrine

Cat.No: T26911

Synonym: 5-Bromotetrandrine,W-198,BrTet,W 198,W198

Cat.No: T31918

Synonym: NSC 114460,NSC114460,NSC-114460

Cat.No: TP1792

Cat.No: T25021

Synonym: Alaphosphin

Cat.No: T33872

Synonym: AI3 52841,AI352841,AI3-52841

Thiacetarsamide

Cat.No: T34841

Cat.No: T25723

Synonym: (+)-Ifosfamide

Cat.No: T27217

Synonym: Duazomycin A,Acetyl-don,Diazomycin A,NSC 51097

Cat.No: T38679

Cat.No: T68781

Cat.No: T69005

Cat.No: T61033

Cat.No: T15180

Target: Caspase

Cat.No: T31215

Synonym: DB766

Cat.No: T69162

Mal-PEG2-VCP-Eribulin

Cat.No: T18278

Target: Others

Etoposide phosphate disodium

Cat.No: T38607

Synonym: BMY-40481 disodium,Etoposide phosphate disodium

Mal-PEG8-Val-Ala-PAB-Exatecan

Cat.No: T77855

Perfluorinated SAHA

Cat.No: T71011

Cat.No: T69993

Biotinyl hexylamine

Cat.No: T36470

S07-2005 (racemic)

Cat.No: T61511

Cat.No: T61485

C8 Dihydroceramide

Cat.No: T38946

Synonym: C8 Dihydroceramide

(E)-5-(2-Bromovinyl)uracil

Cat.No: T35439

Aurora kinase-IN-1

Cat.No: T72522

Cat.No: T36385

Aprinocarsen sodium

Cat.No: T74691

Cat.No: T78841

Cat.No: T36650

(2-pyridyldithio)-PEG1-hydrazine

Cat.No: T38503

Synonym: (2-pyridyldithio)-PEG1-hydrazine

Cat.No: T71279

Cat.No: T36195

2-deoxy-D-Glucose-13C6

Cat.No: T35683

Synonym: 2-deoxy-D-Glucose-13C6

Cat. No.	Product Name	Target	Signaling Pathways
TN2264	Terpinen-4-ol Terpinine-4-ol,4-萜烯醇,4-Carvomenthenol	Others; Endogenous Metabolite	Metabolism; Others
	Terpinen-4-ol (4-Carvomenthenol) 是天然单萜，是茶树油的主要生物活性成分。它通过激活的人单核细胞抑制炎症介质的产生，能显著增强多种化疗和生物制剂的疗效。
TMS0484	Episyringaresinol 4'-O-β-D-glncopyranoside (-)-丁香树脂酚-4-O-β-D-葡萄糖苷,(-)-Syringaresinol 4-O-β-D-glucopyranosi	Others	Others
	Episyringaresinol 4'-O-β-D-glncopyranoside ((-)-Syringaresinol 4-O-β-D-glucopyranosi) 是一种天然的潜在神经炎症抑制剂，分离自鼠尾草 (Alhagi sparsifoliaShap) 。
T2788	Baccatin III 巴卡亭 Ⅲ,浆果赤霉素III,Baccatin Ⅲ	Others	Others
	Baccatin III (Baccatin Ⅲ) 是一种分离自太平洋紫杉树和其近缘种中的天然产物，能够减少 MDSCs 积累并抑制其功能，延缓肿瘤发展进程。
T5753	Flavokawain C 黄卡瓦胡椒素 C,卡瓦胡椒素C	Apoptosis	Apoptosis
	Flavokawain C 是存在卡瓦胡椒根中的一种天然查尔酮，具有发展成为治疗结肠腺癌的化疗药物的潜力。它对 HCT 116 细胞作用的 IC50值为 12.75 μM。
T1082	Benzyl isothiocyanate Benzoylthiocarbimide,苄基异硫氰酸酯,异硫氰酸苯甲酯,Isothiocyanic Acid Benzoyl Ester	Apoptosis; Antibacterial; Antibiotic	Apoptosis; Microbiology/Virology
	Benzyl isothiocyanate (Benzoylthiocarbimide) 是一种具有杀菌活性的天然异硫氰酸酯，最初存在于十字花科蔬菜中。它显示出免疫调节、抗寄生虫、抗生素、抗氧化、抗动脉粥样硬化、抗血管生成、抗转移、抗癌化疗和化学预防活性。
T6S1683	Demethoxycurcumin Curcumin II,去甲氧基姜黄素,Desmethoxycurcumin,脱甲氧姜黄,Monodemethoxycurcumin	Apoptosis; Antioxidant; Antibacterial; Autophagy	Apoptosis; Autophagy; Microbiology/Virology; oxidation-reduction
	Demethoxycurcumin (Desmethoxycurcumin) 是姜黄素的主要活性成分，有抗炎和抗癌作用。
T3867	Alpinetin 山姜素,(-)-alpinetin	BCL; PPAR	Apoptosis; DNA Damage/DNA Repair; Metabolism
	Alpinetin ((-)-alpinetin) 是从草豆蔻中分离得到的一种黄酮类天然产物，能够活化PPAR-γ，具有抗炎、抗菌活性。它通过抑制增殖、调节 Bcl-2 家族和 XIAP 表达、释放细胞色素 c 和激活 caspase 具有很强的抗肝癌和胰腺癌细胞作用。
T5S0661	Koumine	Others	Others
	Koumine 是一种从钩吻中得到的生物碱，具有高效抗肿瘤活性，在肿瘤细胞中能够提高 Bax/Bcl-2 的蛋白比例和 caspase-3 的表达。在类风湿性关节炎动物模型中，它能够预防关节炎的发展。它具有抗焦虑、抗应激、抗银屑病作用，也可用于缓解疼痛的研究。
T6S1027	Tussilagone	Others	Others
	Tussilagone 是Tussilago farfara 的主要活性成分，具有抗炎作用。它抑制盲肠结扎和穿刺导致脓毒症的小鼠的炎症反应，提高其生存率。它改善葡聚糖硫酸钠诱导的小鼠结肠炎的炎症反应。
TN5263	1-[2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one Xanthohumol,黄腐酚	Apoptosis; BCL; PARP; HCV Protease; IAP; Caspase; HIV Protease; NMDAR; p53	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Microbiology/Virology; Neuroscience; Proteases/Proteasome
	1-[2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one (Xanthohumol) 是一种从蛇麻草中提纯的具有多种生物功能的天然产物。黄腐酚对 HIV-1 有效，可能是一种有趣的先导化合物。它可能代表一种用于 HIV-1 感染的新型化疗药物。
T3673	Mollugin 大叶茜草素,Rubimaillin	HER; JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
	Mollugin (Rubimaillin) 是Rubia cordifolia L.中主要的生物活性成分。它能通过 p38-Smad 信号通路增强 BMP-2 的成骨作用。它通过抑制 TNF-α 诱导的 NF-κB 激活起抗癌疗效。
T4S2126	Ginkgetin 银杏双黄酮,银杏素	Apoptosis; Wnt/beta-catenin; COX; STAT; Autophagy	Apoptosis; Autophagy; Cytoskeletal Signaling; Immunology/Inflammation; JAK/STAT signaling; Neuroscience; Stem Cells
	Ginkgetin 是从银杏叶中分离得到的一种双黄酮，具有抗肿瘤、抗炎、神经保护、抗真菌的作用。它也是 Wnt 信号抑制剂，IC50值为 5.92 μM。
T4S1551	Cinnamaldehyde Cinnamic Aldehyde,肉桂醛	HIF	Angiogenesis; Chromatin/Epigenetic
	Cinnamaldehyde (Cinnamic Aldehyde) 具有解热作用。它是镇静剂。它抑制MDA-MB-435S 细胞的侵袭能力与下调miR-27a 的表达有关。它诱导活性氧的产生，发挥血管扩张和抗癌作用。它似乎是一种有希望的候选药物，可作为与 5-氟尿嘧啶 (5-FU) 和奥沙利铂 (OXA) 这两种用于 CRC 治疗的化疗药物联合治疗的辅助剂。其作用的可能机制可能涉及药物代谢基因的调节。它在抑制黑色素瘤的发生和发展方面具有一定的作用，其作用机制可能表现为抑制VEGF 和HIF-α的表达，从而使血管模拟和黑色素瘤细胞新生血管的形成，促进肿瘤的生长。
TN6651	Picrasidine Q
	Picrasidine Q has the capacity of anti-cell transformation and anti-cancer, it might be a chemopreventive and chemotherapeutic agent by direct targeting FGFR2 and inhibiting cell proliferation of ESCC cells.
TN1538	Curzerenone 莪术呋喃烯酮,莪术酮	Caspase; Antifection	Apoptosis; Microbiology/Virology; Proteases/Proteasome
	Curzerenone holds great promise for use in chemopreventive and chemotherapeutic strategies, it has slightly effective against E. coli (IZ = 10.8 ± 0.52).
T40939	Ginger extract
	Ginger extract demonstrates (exhibits) anti-cancer, anti-inflammatory, and chemotherapeutic properties in living organisms (in vivo).
TN4341	IVHD-valtrate	Mdm2; BCL; PARP; Caspase; p53	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Proteases/Proteasome
	VHD-valtrate has anticancer effects against human ovarian cancer cells in vitro and in vivo, it is a potential therapeutic agent for ovarian cancer, providing a basis for development of the compound as a novel chemotherapeutic agent.
TN3446	Aristolactam FI	Others	Others
	Aristolactam FI shows platelet aggregation inhibitory activity.It is a potential cancer chemotherapeutic and chemopreventive agent.
TN3468	Atractylochromene	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	Atractylochromene is an inhibitor of β-catenin dependent Wnt pathway, it may be a potential chemotherapeutic agent for the prevention and treatment of human colon cancer.
TN2118	Lup-20(29)-en-28-oic acid Pulsatilla saponin D,白头翁皂苷D	ERK; mTOR; Autophagy	Autophagy; MAPK; PI3K/Akt/mTOR signaling
	Lup-20(29)-en-28-oic acid exhibits anticancer activities in various cancer types, it Inhibits autophagic flux and synergistically enhances the anticancer activity of chemotherapeutic agents against HeLa cells.Pulsatilla saponin D has strong haemolytic act
TN3348	(+)-Acuminatin Acuminatin	PAFR	GPCR/G Protein
	(+)-Acuminatin exerts hepatoprotective activities, perhaps by serving as a potent antioxidant. (+)-trans-Acuminatin, and (+)-cis-acuminatin show weak activity against platelet aggregation with IC50 values of 108.5 and 90.02 uM, respectively. (+)-Acuminatin, and machilin G show dose-dependent potent inhibitory activities against PLCgamma1 in vitro with IC50 values ranging from 8.8 to 26.0 microM, the inhibition of PLCgamma1 may be an important mechanism for an antiproliferative effect on the huma...
TN2177	Sanggenol L	c-Myc; NF-κB	Cell Cycle/Checkpoint; NF-κB
	Sanggenol L shows higher cytotoxicity against human oral tumor cell lines (HSC-2 and HSG) than against normal human gingival fibroblasts (HGF), it induces apoptosis via caspase activation and inhibition of NF-κB/IκBα± phosphorylation as a potent chemother
TN4046	Excisanin A	MMP; FAK; PARP; GSK-3; NF-κB; Wnt/beta-catenin; Akt; Caspase; PI3K; Prostaglandin Receptor; JNK	Angiogenesis; Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; GPCR/G Protein; Immunology/Inflammation; MAPK; NF-κB; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Stem Cells; Tyrosine Kinase/Adaptors
	ExcisaninA may be a potent inhibitor of AKT signaling pathway in tumor cells, it can inhibit invasion by suppressing MMP-2 and MMP-9 expression, it may be a potential anti-metastatic chemotherapeutic agent for the treatment of breast cancer. Excisanin A shows comparable inhibitory effects on the LPS-induced production of NO and PGE2, and activation of NF-kappaB without affecting cell viability.Excisanin A induces apoptosis in colon cancer cell line SW620 as determined by Annexin V staining, the ...
TN3152	6-Acetonyldihydrochelerythrine	ERK; BCL; Akt; HIV Protease; PPAR; p53	Apoptosis; Cytoskeletal Signaling; DNA Damage/DNA Repair; MAPK; Metabolism; Microbiology/Virology; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	6-Acetonyldihydrochelerythrine exhibits significant antioxidant activities, it exhibits significant anti-HIV activity in H9 lymphocytes with EC50 and TI (Therapeutic Index) values of 1.77 microg/mL and 14.6, respectively. 6-Acetonyldihydrochelerythrine is

天然产物

Cat.No: TN2264

Synonym: Terpinine-4-ol,4-萜烯醇,4-Carvomenthenol

Target: Others, Endogenous Metabolite

Episyringaresinol 4'-O-β-D-glncopyranoside

Cat.No: TMS0484

Synonym: (-)-丁香树脂酚-4-O-β-D-葡萄糖苷,(-)-Syringaresinol 4-O-β-D-glucopyranosi

Target: Others

Cat.No: T2788

Synonym: 巴卡亭 Ⅲ,浆果赤霉素III,Baccatin Ⅲ

Target: Others

Cat.No: T5753

Synonym: 黄卡瓦胡椒素 C,卡瓦胡椒素C

Target: Apoptosis

Benzyl isothiocyanate

Cat.No: T1082

Synonym: Benzoylthiocarbimide,苄基异硫氰酸酯,异硫氰酸苯甲酯,Isothiocyanic Acid Benzoyl Ester

Target: Apoptosis, Antibacterial, Antibiotic

Demethoxycurcumin

Cat.No: T6S1683

Synonym: Curcumin II,去甲氧基姜黄素,Desmethoxycurcumin,脱甲氧姜黄,Monodemethoxycurcumin

Target: Apoptosis, Antioxidant, Antibacterial, Autophagy

Cat.No: T3867

Synonym: 山姜素,(-)-alpinetin

Target: BCL, PPAR

Cat.No: T5S0661

Target: Others

Cat.No: T6S1027

Target: Others

1-[2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one

Cat.No: TN5263

Synonym: Xanthohumol,黄腐酚

Target: Apoptosis, BCL, PARP, HCV Protease, IAP, Caspase, HIV Protease, NMDAR, p53

Cat.No: T3673

Synonym: 大叶茜草素,Rubimaillin

Target: HER, JAK

Cat.No: T4S2126

Synonym: 银杏双黄酮,银杏素

Target: Apoptosis, Wnt/beta-catenin, COX, STAT, Autophagy

Cat.No: T4S1551

Synonym: Cinnamic Aldehyde,肉桂醛

Target: HIF

Cat.No: TN6651

Cat.No: TN1538

Synonym: 莪术呋喃烯酮,莪术酮

Target: Caspase, Antifection

Cat.No: T40939

Cat.No: TN4341

Target: Mdm2, BCL, PARP, Caspase, p53

Aristolactam FI

Cat.No: TN3446

Target: Others

Atractylochromene

Cat.No: TN3468

Target: Wnt/beta-catenin

Lup-20(29)-en-28-oic acid

Cat.No: TN2118

Synonym: Pulsatilla saponin D,白头翁皂苷D

Target: ERK, mTOR, Autophagy

Cat.No: TN3348

Synonym: Acuminatin

Target: PAFR

Cat.No: TN2177

Target: c-Myc, NF-κB

Cat.No: TN4046

Target: MMP, FAK, PARP, GSK-3, NF-κB, Wnt/beta-catenin, Akt, Caspase, PI3K, Prostaglandin Receptor, JNK

6-Acetonyldihydrochelerythrine

Cat.No: TN3152

Target: ERK, BCL, Akt, HIV Protease, PPAR, p53

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