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63

抑制剂 & 化合物

41

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T22223	3PO	Glucokinase; Autophagy	Autophagy; Metabolism
	3PO 是一种 PFKFB3 的小分子抑制剂，IC50值为22.9 μM。它抑制几种人类恶性造血和腺癌细胞系的增殖，IC50在1.4到24 μM 之间。它抑制葡萄糖摄取，并降低 Fru-2,6-BP、乳酸、ATP、NAD+ 和 NADH 的细胞内浓度。
T4367	Mycro 3 Mycro-3	c-Myc; Autophagy	Autophagy; Cell Cycle/Checkpoint
	Mycro 3 在全细胞分析中对 c-Myc 具有强效选择性，可用于胰腺癌的研究。
T23372	SMIFH2	Others	Others
	SMIFH2 是formin 特异性抑制剂。它利用 Formins 阻碍肌动蛋白聚合，影响肌动蛋白细胞骨架。
T8796	CAN508	CDK	Cell Cycle/Checkpoint
	CAN508 是一种有效的 ATP 竞争性 CDK9/cyclin T1 抑制剂，IC50 为 0.35 μM。它还是 Cdk2-cyclin E 对 ATP 的竞争性抑制剂，Ki 和 IC50 值分别为 13.3 和 20 µM。它对 CDK9/cyclin T 的选择性是其他 CDK/cyclin 复合物的 38 倍，有抗肿瘤活性。
T8320	J14 J-14	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	J14 是一种可逆的 sulfiredoxin 抑制剂，IC50=8.1 μM。它能够抑制sulfiredoxin 诱导氧化应激，使细胞内ROS 积累，导致细胞毒性和癌细胞死亡。
T6609	NMS-E973	HSP	Cytoskeletal Signaling; Metabolism
	NMS-E973 是一种有效且选择性的 Hsp90 抑制剂，与 Hsp90 结合的 DC50小于 10 nM。它能够穿越血脑屏障，具有抗肿瘤效果。
T8766	GOT1 inhibitor-1 GOT1 inhibitor 2c	Others	Others
	GOT1 inhibitor-1 (GOT1 inhibitor 2c) 是一种新型的、非共价的谷氨酸草酰乙酸转氨酶 1 (GOT1) 抑制剂(IC50:8.2 uM)，是一种戊酸衍生物。它可用于以及胰腺导管腺癌 (PDAC) 。
T9891	PARP1-IN-8 N-(3-chlorophenyl)-3-(1-oxo-4-phenylphthalazin-2(1H)-yl)propanamide	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	PARP1-IN-8 (N-(3-chlorophenyl)-3-(1-oxo-4-phenylphthalazin-2(1H)-yl)propanamide) 是PARP1的有效抑制剂（IC50 = 97 nM）。
T12854	SBI-797812	NAMPT	Metabolism
	SBI-797812 是在结构上类似于活性位点定向的 NAMPT 抑制剂的化合物，能够阻断这些抑制剂与 NAMPT 的结合。它将 NAMPT 反应平衡转向 NMN 形成，提高 NAMPT 对 ATP 的亲和力，稳定 His247 处的磷酸化 NAMPT，增加焦磷酸盐副产物的消耗，并通过 NAD+钝化反馈抑制。
T2613	Almorexant 阿莫伦特,ACT 078573	OX Receptor	GPCR/G Protein; Neuroscience
	Almorexant (ACT 078573) 是一种有效的竞争性食欲素 1 受体 (OX1)/食欲素 2 受体 (OX2) 双重拮抗剂，OX1 和 OX2 的 Ki 值分别为 1.3 和 0.17 nM。
T6155	Almorexant hydrochloride ACT-078573 hydrochloride,Almorexant HCl	OX Receptor	GPCR/G Protein; Neuroscience
	Almorexant hydrochloride (ACT-078573 hydrochloride) 是一种有效的竞争性食欲素 1 受体(OX1)/食欲素 2 受体 (OX2) 双重拮抗剂，OX1 和 OX2 的 Ki 值分别为 1.3 和 0.17 nM。
T13111	Tegadifur 40497S,FD 1	Others	Others
	Tegadifur (40497S) 是一种可口服的抗肿瘤化合物，具有抗新陈代谢作用，常与尿嘧啶林和治疗直肠腺癌。
TNU0031	5-Hydroxyuridine OHUrd	Nucleoside Antimetabolite/Analog	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	5-Hydroxyuridine (OHUrd) 是一种嘌呤核苷类似物，具有潜在的抗肿瘤活性，对人结肠腺癌细胞系显示出细胞毒。
T15558	GSK319347A	IκB/IKK	NF-κB
	GSK319347A 是一种具有选择性和有效性的 TBK1 和 IKKε 的双重抑制剂，具有潜在的抗肿瘤活性，对 IKK2 活性有抑制作用，可用于研究膀胱癌和肺腺癌。
T77522	BCAT-IN-4	Others	Others
	BCAT-IN-4 是一种具有有效性的 BCAT 抑制剂对 hBCATc 的 IC50 值为 2.35 μM。 BCAT-IN-4 具有抗癌活性，可用于研究胰腺导管腺癌。
T79213	AZD4747	Ras	GPCR/G Protein; MAPK
	AZD4747 是一种可透过血脑屏障且具有选择性和有效性的突变GTP酶 KRAS G12C 抑制剂，具有潜在的抗肿瘤活性，可用于研究胰腺癌和结直肠腺癌。
T77685	6-Bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile	PDK	PI3K/Akt/mTOR signaling
	6-Bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile 是一种 PDK1 抑制剂，具有抗癌和抗增殖活性，可用来研究血管肉瘤、腺癌、多骨髓瘤、牛皮癣、前列腺癌和和阿尔茨海默病。
T76856	Andecaliximab GS-5745	MMP; Virus Protease	Microbiology/Virology; Proteases/Proteasome
	Andecaliximab 是一种靶向基质金属蛋白酶 9 (MMP9) 的重组 IgG4 单克隆抗体。Andecaliximab 在特发性肺纤维化小鼠模型中显示出抗纤维化作用。Andecaliximab 可用于研究胃腺癌和特发性肺纤维化 (IPF) 以及登革热病毒。
T60446	LCS3	Apoptosis; Glutathione reductase	Apoptosis; oxidation-reduction
	LCS3是一种可逆和非竞争性的谷胱甘肽二硫化物还原酶（GSR）和硫氧还蛋白还原酶1（TXNRD1）的协同抑制剂，IC50分别为3.3μM 和3.8μM。LCS3具有抗肿瘤活性，可诱导细胞凋亡，可用于研究肺腺癌（LUAD）。
T62281	PARP-1-IN-2	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	PARP-1-IN-2 是一种有效且可透过血脑屏障的 PARP1 抑制剂（IC50： 149 nM）。PARP-1-IN-2 在细胞实验中对人肺腺癌上皮细胞系 A549 显示出显著的抗增殖活性。PARP-1-IN-2 可诱导 A549 细胞凋亡。
T11793	KY-05009	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	KY-05009 是 ATP 竞争性的、有效的 TNIK 抑制剂，Ki 为 100 nM。KY-05009抑制人肺腺癌细胞中 TGF-β1 诱导的上皮-间质转化。KY-05009 还抑制TNIK 的蛋白表达和Wnt 靶基因的转录活性，并诱导癌细胞凋亡，显示抗癌活性。
T76873	Nidanilimab CAN04	IL Receptor	Immunology/Inflammation
	Nidanilimab (CAN04) 是一种完全人源化的 IL1RAP 单克隆抗体，其 Kd 值为 1.10 pM。Nidanilimab 具有抗肿瘤活性，切断 IL1α 和 IL1β 信号通路，并诱导免疫系统破坏肿瘤细胞。Nidanilimab 可用于研究非小细胞肺癌 (NSCLC) 和胰腺导管腺癌 (PDAC) 等实体癌。
T36126	TMP-153
	Acyl-CoA:cholesterol acyltransferase (ACAT) catalyses the esterification of excess cellular cholesterol with fatty acids and is important for intestinal cholesterol absorption, hepatic lipoprotein secretion, and cholesterol accumulation in vascular tissues. ACAT inhibitors improve plasma lipid profile and ameliorate proteinuria in nephrotic animals. TMP-153 is a quinolyl derivative that inhibits ACAT with IC50 values of 5-10 nM in various animals. At 0.5-1.5 mg/kg, TMP-153 dose-dependently reduc...
T60202	MMRi62 7-[(2,3-dichlorophenyl)-(pyridin-2-ylamino)methyl]quinolin-8-ol	Ferroptosis	Apoptosis
	MMRi62 (7-[(2,3-dichlorophenyl)-(pyridin-2-ylamino)methyl]quinolin-8-ol) 是一种铁死亡 (ferroptosis) 诱导剂，靶向 MDM2-MDM4 (抑癌基因 p53 负调控因子)。MMRi62 对胰腺导管腺癌 (PDAC) 细胞显示出 p53 独立的促凋亡 (apoptosis) 活性，并诱导其自噬 (autophagy)。MMRi62 诱导铁死亡，伴随着活性氧增加和铁蛋白重链 (FTH1) 溶酶体降解。MMRi62 还可导致突变型 p53 的蛋白酶体降解，并对具有 KRAS 和 TP53 高频突变特征的原位异种移植 PDAC 小鼠模型具有体内药效。
T36083	DS-7423	PI3K; mTOR	PI3K/Akt/mTOR signaling
	DS-7423 是PI3K 和mTOR 的有效抑制剂，抑制PI3Kα 和 mTOR 的IC50分别为15.6 nM 和 34.9 nM。DS-7423表现出抗癌活性。
T31406	Dezaguanine Dezaguanina,NSC 261726,CI-908,CI 908
	Dezaguanine is a novel antipurine antimetabolite with significant activity against transplantable rodent solid tumors, particularly breast adenocarcinoma.
TP2478	WT-1 A1 Tyr-Met-Phe-Pro-agn-Ala-Pro-Tyr-Leu
	WT-1 A1 is an attractive target for immunotherapy in patients with pancreatic adenocarcinoma.
T83077	Anticancer agent 86
	Anticanceragent 86（compound 6i）对乳腺癌细胞展现出显著的抑制潜力。
T26605	Alyssin
	Alyssin is a sulforaphane homolog and antioxidant. It induces phase II enzymes and increases Nrf2 levels in adenocarcinoma cells. It decreases the metabolism of polycyclic aromatic hydrocarbons, supressing the risk of carcinogenesis in vitro.
T13161	Tin-protoporphyrin IX 锡原卟啉IX,SnPPIX	Others	Others
	Tin-protoporphyrin IX is a potent inhibitor of Heme oxygenase-1 (HO-1). It sensitizes pancreatic ductal adenocarcinoma (PDAC) tumors to chemotherapy in mice models.
T69106	Avarol
	Avarol induces apoptosis in pancreatic ductal adenocarcinoma cells by activating PERK-eIF2α-CHOP signaling. Avarl also acts as a competitive AChE inhibitor which are non-hepatotoxic and neuroprotective agents for Alzheimer's disease.
T24693	QD325 QD 325,QD-325
	QD325 is a potent redox modulator for the Treatment of Pancreatic Ductal Adenocarcinoma. Nascent RNA sequencing following treatments with QD325 revealed induction of stress responses in the nucleus, endoplasmic reticulum, and mitochondria of pancreatic ca
T71060	IST-622
	IST-622 is a unique topoisomerase inhibitor, showing significant growth-inhibitory effects against large-cell lung cancer (Lu-116) and gastric adenocarcinoma (St-4).
T27834	Limonin glucoside CCRIS-6986,CCRIS 6986,CCRIS6986
	Limonin glucoside is a natural product in citrus fruits. It inhibits expression of HIV-1 and HTLV-1 in infected cells, induces apoptosis in colon adenocarcinoma cells, and exhibits larvicidal activity against species of Aedes.
T62079	MEK4 inhibitor-2
	MEK4 inhibitor-2 是一种新型的抗胰腺癌的MEK4抑制剂，其IC50值为 83 nM。
T10588	BPI-9016M	Others	Others
	BPI-9016M is an effective, orally active, and selective dual inhibitor of c-Met and AXL tyrosine kinases. It suppresses tumor cell growth, invasion, and migration of lung adenocarcinoma.
T61806	Antitumor agent-44
	Antitumor agent-44 (Compound 5n) elicits potent antitumor effects by inducing disruption of mitochondrial homeostasis, cell cycle arrest, and apoptosis in human adenocarcinoma cells. Moreover, Antitumor agent-44 demonstrates significant anti-tumor activity in a lung cancer cell xenograft mice model [1].
T40206	MEK4 inhibitor-1 MEK4 inhibitor-1
	MEK4 inhibitor-1 is a newly developed compound specifically designed to inhibit the activity of MEK4, a key enzyme involved in pancreatic adenocarcinoma, with an IC 50 value of 61 nM.
T62748	Nampt-IN-9
	Nampt-IN-9 (Compound 8) 是一种有效的 NAMPT 抑制剂，具有抗癌作用。Nampt-IN-9 能够用于研究胰腺导管腺癌。
T70001	Pyrazinib
	Pyrazinib is a novel inhibitor of angiogenesis and metabolism of oesophageal adenocarcinoma (oac) radioresistance, significantly inhibiting the secretion of il-6, il-4, il-8 and il-13 cytokines from in oac radioresistant cells
T78251	Sotigalimab
	Sotigalimab 是一种CD40激动性单克隆抗体，适用于转移性胰腺癌研究。
T69073	COTC
	COTC is a bacterial metabolite that has anticancer activity and inhibits glyoxalase in the presence of glutathione (GSH) and the proliferation of HeLa cells, as well as reduces tumor growth and improves survival in an Ehrlich murine spontaneous adenocarcinoma model.
T77180	Retifanlimab
	Retifanlimab为一种抗程序性细胞死亡蛋白1(anti-PD-1)单克隆抗体(mAb)，主要用于胃食道腺癌(GEA)的研究。
T76855	Gresonitamab
	Gresonitamab (AMG 910) 是一种半衰期延长 (HLE) 双特异性 T 细胞接合物 (BiTE) 抗体，靶向 CD3阳性 T 细胞和表达 CLDN18.2的肿瘤细胞。Gresonitamab 可用于腺癌的研究。
T38302	Chrysomycin B
	Chrysomycin B 是分离自链霉菌的一种抗生素。Chrysomycin B 能引起人肺腺癌 A549 细胞系的 DNA 损伤，并抑制拓扑异构酶 II。
T78306	Ulenistamab PBP1510
	Ulenistamab (PBP1510)为首创人源化IgG1单克隆抗体，专一靶向胰腺癌上调因子(PAUF)，适用于胰腺癌(PC)的研究。
T70646	Deltarasin HCl
	Deltarasin is a high affinity PDEδ-KRAS interaction inhibitor. Deltarasin can inhibit KRAS-PDEδ interactions by binding to a hydrophobic pocket on PDEδ, resulting in the impairment of cell growth, KRAS activity, and RAS/RAF signaling in human pancreatic ductal adenocarcinoma cell lines. The anti-cancer cell activity of deltarasin can be enhanced by simultaneously blocking tumor protective" autophagy
T82605	DB21, Galectin-1 Antagonist	Galectin	Immunology/Inflammation
	DB21, Galectin-1 Antagonist 是一种用于抑制galectin-1 (GAL1)与细胞表面聚糖结合的二苯并呋喃缀合肽模拟物。在黑色素瘤、肺腺癌和卵巢癌模型中，该化合物能增强血管生成和肿瘤生长的抑制效果。
T69193	SN-28049
	SN-28049 SN is a DNA intercalating drug that binds selectively to GC-rich DNA and shows curative activity against the Colon 38 adenocarcinoma in mice. SN 28049 has a complex action that may involve poisoning of topo IIalpha, suppression of topo I and inhibition of gene transcription from promoters with SP-1 sites. These actions may contribute to the promising experimental solid tumour anticancer activity of SN 28049.
T77450	Vantictumab OMP-18R5
	Vantictumab (OMP-18R5)为全人源IgG2单克隆抗体，针对FZD1/2/5/7/8受体抑制Wnt信号通路。该抗体适用于研究治疗转移性HER2阴性乳腺癌及转移性胰腺腺癌。

化合物

Cat.No: T22223

Target: Glucokinase, Autophagy

Cat.No: T4367

Synonym: Mycro-3

Target: c-Myc, Autophagy

Cat.No: T23372

Target: Others

Cat.No: T8796

Target: CDK

Cat.No: T8320

Synonym: J-14

Target: Reactive Oxygen Species

Cat.No: T6609

Target: HSP

GOT1 inhibitor-1

Cat.No: T8766

Synonym: GOT1 inhibitor 2c

Target: Others

Cat.No: T9891

Synonym: N-(3-chlorophenyl)-3-(1-oxo-4-phenylphthalazin-2(1H)-yl)propanamide

Target: PARP

Cat.No: T12854

Target: NAMPT

Cat.No: T2613

Synonym: 阿莫伦特,ACT 078573

Target: OX Receptor

Almorexant hydrochloride

Cat.No: T6155

Synonym: ACT-078573 hydrochloride,Almorexant HCl

Target: OX Receptor

Cat.No: T13111

Synonym: 40497S,FD 1

Target: Others

5-Hydroxyuridine

Cat.No: TNU0031

Synonym: OHUrd

Target: Nucleoside Antimetabolite/Analog

Cat.No: T15558

Target: IκB/IKK

Cat.No: T77522

Target: Others

Cat.No: T79213

Target: Ras

6-Bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile

Cat.No: T77685

Target: PDK

Cat.No: T76856

Synonym: GS-5745

Target: MMP, Virus Protease

Cat.No: T60446

Target: Apoptosis, Glutathione reductase

Cat.No: T62281

Target: PARP

Cat.No: T11793

Target: Wnt/beta-catenin

Cat.No: T76873

Synonym: CAN04

Target: IL Receptor

Cat.No: T36126

Cat.No: T60202

Synonym: 7-[(2,3-dichlorophenyl)-(pyridin-2-ylamino)methyl]quinolin-8-ol

Target: Ferroptosis

Cat.No: T36083

Target: PI3K, mTOR

Cat.No: T31406

Synonym: Dezaguanina,NSC 261726,CI-908,CI 908

Cat.No: TP2478

Synonym: Tyr-Met-Phe-Pro-agn-Ala-Pro-Tyr-Leu

Anticancer agent 86

Cat.No: T83077

Cat.No: T26605

Tin-protoporphyrin IX

Cat.No: T13161

Synonym: 锡原卟啉IX,SnPPIX

Target: Others

Cat.No: T69106

Cat.No: T24693

Synonym: QD 325,QD-325

Cat.No: T71060

Limonin glucoside

Cat.No: T27834

Synonym: CCRIS-6986,CCRIS 6986,CCRIS6986

MEK4 inhibitor-2

Cat.No: T62079

Cat.No: T10588

Target: Others

Antitumor agent-44

Cat.No: T61806

MEK4 inhibitor-1

Cat.No: T40206

Synonym: MEK4 inhibitor-1

Cat.No: T62748

Cat.No: T70001

Cat.No: T78251

Cat.No: T69073

Cat.No: T77180

Cat.No: T76855

Cat.No: T38302

Cat.No: T78306

Synonym: PBP1510

Cat.No: T70646

DB21, Galectin-1 Antagonist

Cat.No: T82605

Target: Galectin

Cat.No: T69193

Cat.No: T77450

Synonym: OMP-18R5

Cat. No.	Product Name	Target	Signaling Pathways
T1166	Ellipticine 玫瑰树碱,NSC 71795,Elliptisine	Topoisomerase	DNA Damage/DNA Repair
	Ellipticine (Elliptisine) 是一种有效的抗肿瘤剂，抑制 DNA 拓扑异构酶 II 活性，对白血病、神经母细胞瘤和胶质母细胞瘤有部分活性。
TN5086	Syringetin	Others	Others
	Syringetin 是一种存在于葡萄和葡萄酒中的类黄酮衍生物，可促进 B16F10 细胞的黑色素生成，抑制人肺腺癌中成骨细胞介导的破骨细胞生成。
T36115	Colchicoside 3-Demethylcolchicine glucoside	Others	Others
	Colchicoside (3-Demethylcolchicine glucoside) 提取自嘉兰，在胰腺癌小鼠模型中显示出疗效。
TN2430	Glucodigifucoside 洋地黄毒苷元葡萄糖基岩藻糖苷,洋地黄
	Glucodigifucoside 是可从洋地黄种子中分离得到的强心苷，对人肾腺癌细胞有特异性细胞毒性。
T3786	Tomatine lycopersicin,番茄素,番茄碱	Apoptosis; Proteasome	Apoptosis; Proteases/Proteasome; Ubiquitination
	Tomatine (lycopersicin) 是从番茄植物中发现的一种糖苷生物碱。它促进神经母细胞瘤细胞中核凋亡诱导因子的上调，还抑制20S 蛋白酶体活性。它以 RIP1 激酶和 caspase 非依赖性的方式引发神经毒性。
T35673	Stictic Acid Scopularic acid	Others	Others
	Stictic Acid (Scopularic acid) 分离自苏门答腊地衣 Stereocaulon montagneanum，可抑制 HT-29 人结肠腺癌细胞的生长，IC50 为 29.29 μg/ml。
T5753	Flavokawain C 黄卡瓦胡椒素 C,卡瓦胡椒素C	Apoptosis	Apoptosis
	Flavokawain C 是存在卡瓦胡椒根中的一种天然查尔酮，具有发展成为治疗结肠腺癌的化疗药物的潜力。它对 HCT 116 细胞作用的 IC50值为 12.75 μM。
TN2347	Methylsticin 麻醉椒苦素,Methysticin	Others	Others
	Methylsticin (Methysticin) 是一种卡瓦内酯，从卡瓦根中分离得到。它能够抑制破骨细胞形成的活性。
TN1620	Eriocalyxin B 毛萼乙素	Apoptosis; cAMP; NF-κB; STAT	Apoptosis; GPCR/G Protein; JAK/STAT signaling; NF-κB; Stem Cells
	Eriocalyxin B 是从中草药枇杷素中分离得到的一种二萜类天然产物，可诱导细胞凋亡，具有抗癌和抗炎作用。
T36473	trans-Nerolidol
	trans-Nerolidol is a sesquiterpene that has been found in various plants, includingC. sativa, and has diverse biological activities, including antimicrobial, antioxidant, anticancer, and insecticidal properties.1,2,3,4In a disc assay,trans-nerolidol inhibits the growth ofS. aureus,B. subtilis,E. coli, andS. cerevisiaewith zones of inhibition measuring 10, 9, 10, and 4 mm, respectively.2It reduces viability of CaCo-2 adenocarcinoma cells with an IC50value of 28.7 mg/L and reduces production of re...
T4672	Brevilin A	Apoptosis; Anti-infection; JAK; STAT; Autophagy	Angiogenesis; Apoptosis; Autophagy; Chromatin/Epigenetic; JAK/STAT signaling; Microbiology/Virology; Stem Cells
	Brevilin A 是从Centipeda minima 中分离的倍半萜内酯，具有抗癌活性。它通过线粒体途径和 PI3K/AKT/mTOR 失活诱导结肠腺癌细胞 CT26 的凋亡和自噬。它是一种选择性JAK-STAT 信号通路抑制剂，通过减弱 JAK 信号和阻塞 STAT3 信号起作用。
T7033	Rosmanol	Antioxidant; COX	Immunology/Inflammation; Neuroscience; oxidation-reduction
	Rosmanol 能够显著抑制脂多糖诱导的 INOS、COX-2 的表达，抑制低密度脂蛋白的氧化，并具有抗炎作用。
T1660	Silibinin 水飞蓟宾 A,水飞蓟宾,Silibinin A,Silybin,Silymarin I	Reactive Oxygen Species; Autophagy	Autophagy; Immunology/Inflammation; Metabolism; NF-κB
	Silibinin (Silybin) 是水飞蓟的主要活性成分，具有抗癌和化疗预防作用，能抑制细胞增殖和迁移。
TMA1841	Dihydrodaidzin	Others	Others
	Dihydrodaidzin shows cytotoxic activities against human stomach carcinoma (Hs 740.T, Hs 756 T), breast adenocarcinoma (Hs 578 T, Hs 742.T), and prostate carcinoma (DU 145, LNCaP-FGC) cell lines.
T3S2016	Epoxylathyrol	Others	Others
	Epoxylathyrol derivatives have modulation of ABCB1-mediated multidrug resistance in human colon adenocarcinoma and mouse T-Lymphoma cells.
T70955	Vinaxanthone SM-345431	Phospholipase; Antibacterial	Metabolism; Microbiology/Virology
	Vinaxanthone (SM-345431) 是一种从青霉菌中提取的小分子化合物，是一种具有选择性和有效性的 semaphorin3A、phospholipase C (PLC) 和 FabI 抑制剂，抑制semaphorin3A 和 FabI。Vinaxanthone 具有抗菌活性，阻止细胞内脂肪酸合成，抑制金黄色葡萄球菌的生长。
TN5274	Yunnancoronarin A	Others	Others
	Yunnancoronarin A shows cytotoxicity against the lung adenocarcinoma cells A549 and leukemia cells K562, with the IC(50) value of 2.20 microM.
TN1359	Aflatoxin G1 黄曲霉毒素G1,黄曲霉毒素 G1	TNF; NF-κB	Apoptosis; NF-κB
	Aflatoxin G1 (AFG1 ), a member of the AF family with cytotoxic and carcinogenic properties, could cause DNA damage in alveolar type II (AT-II) cells and induce lung adenocarcinoma.
TN1872	Linderone	Others	Others
	Linderone A shows anticancer activity against A549 non-small cell lung cancer cells and PC-3 prostate adenocarcinoma cell line.
TN3605	Casegravol	Others	Others
	Casegravol shows antiproliferative activity against human gastric adenocarcinoma (MK-1), human uterus carcinoma (HeLa), and murine melanoma (B16F10) cells.
TN1523	Conicasterol	Others	Others
	Conicasterol displays marked cytotoxic activity against human breast adenocarcinoma cell line (MCF-7) with the IC50 value of 6.23 ug/mL.
TN3465	Atalantoflavone	Antifection	Microbiology/Virology
	Atalantoflavone shows urease inhibitory potential. It displays weak cytotoxic activity against the human Caucasian prostate adenocarcinoma cell line PC-3.
TN4352	Jatamanvaltrate B	Others	Others
	Jatamanvaltrate B shows cytotoxicity against lung adenocarcinoma (A549), metastatic prostate cancer (PC-3M), colon cancer (HCT-8),and hepatoma (Bel7402) cell lines.
TN1464	Camellianin A	RAAS	Endocrinology/Hormones
	Camellianin A has anticancer activity, it can inhibit the proliferation of the human hepatocellular liver carcinoma Hep G2 and human breast adenocarcinoma MCF-7 cell lines in a dose-dependent manner and induce the significant increase of the G0/G1 cell po
TN2492	1,4,5,6-Tetrahydroxy-7,8-diprenylxanthone	Others	Others
	1,4,5,6-Tetrahydroxy-7,8-diprenylxanthone has moderate cytotoxicities against breast cancer (MDA-MB-435S) and lung adenocarcinoma (A549) cell lines, but lacks antifungal activity against Candida albicans.
TN3870	Iriflophenone 2-O-Rhamnoside Dimethylmatairesinol	Others	Others
	Dimethylmatairesinol can reduce the amount of Immunoglobulin E (IgE) secreted by human myeloma U266 cells, it has potential as an anti-allergic agent. Dimethylmatairesinol also exhibits significant cytotoxicity against three human tumor cells(A-549 lung c
TN2493	1,4,5,6-Tetrahydroxy-7-prenylxanthone	Others	Others
	1,4,5,6-Tetrahydroxy-7-prenylxanthone has anti-cancer activity, it shows moderate cytotoxicities against breast cancer (MDA-MB-435S) and lung adenocarcinoma (A549) cell lines; it also exhibits moderate activities with GI50 (Growth inhibitory) values of 2.
TN4355	Jolkinol A	Others	Others
	Jolkinol A can inhibit both MCF-7 (breast adenocarcinoma), NCI-H460 (non-small cell lung cancer) cell lines, with GI50 values ranging between 40.9 microM and 95.3 microM.
TN2529	1-Decarboxy-3-oxo-ceanothic acid	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	1-Decarboxy-3-oxo-ceanothic acid shows in vitro cytotoxic activity in a human ovarian adenocarcinoma cell line, the cytotoxic effect is mediated, at least in part, by the induction of apoptosis. It shows cytotoxic against OVCAR-3 and HeLa cancer cell line
TN3646	Chlorovaltrate K	Others	Others
	Chlorovaltrate K shows moderate cytotoxicity against lung adenocarcinoma (A 549), metastatic prostate cancer (PC-3M), colon cancer (HCT-8) and hepatoma (Bel 7402) cell lines with IC50 values of 0.89-9.76 uM.
T81452	Pixinol
	Pixinol，天然糖苷，对GLC4人肺癌细胞株和COLO 320腺癌细胞株显示出细胞毒性，IC50值分别为71 µM与43 µM。
TN5249	Volvaltrate B	Others	Others
	Volvaltrate B shows cytotoxic activity against the lung adenocarcinoma (A549), metastatic prostate cancer (PC-3M), colon cancer (HCT-8), and hepatoma (Bel7402) cell lines, with IC50 values of 8.5, 2.0, 3.2, and 6.1 uM, respectively.
TN2945	3-Hydroxybakuchiol	ATPase; Caspase	Apoptosis; Membrane transporter/Ion channel; Proteases/Proteasome
	3-Hydroxybakuchiol exerts cytotoxic and anti-proliferative effects on the TA3/Ha mouse mammary adenocarcinoma cell line and induces a decrease in the mitochondrial transmembrane potential, the activation of caspase-3, the opening of the mitochondrial perm
TN2684	2,3,23-Trihydroxy-12-oleanen-28-oic acid	Others	Others
	2β,3β,23α-Trihydroxy-12-oleanen-28-oic acid shows cytotoxic activities to human lung adenocarcinoma(A-549)cell lines. 2α,3β,23-Trihydroxyolean-12-en-28-oic acid and 2α,3β,23-trihydroxyurs-12-en-28-oic acid exhibit cytotoxicity in vitro against the growth of human cancer cells lines HepG-2,with IC50 values of 16.13 ± 3.83, 15.97 ± 2.47 uM, respectively.
TN3009	4',5,7-Trihydroxy-6-prenylflavone	Others	Others
	6-Prenylapigenin(4',5,7-Trihydroxy-6-prenylflavone) shows potent inhibitory activity on melanin formation, it may be potential sources for skin whitening agents. It also shows moderate cytotoxicities against breast cancer (MDA-MB-435S) and lung adenocarci
TN4716	Oplodiol	Influenza Virus	Microbiology/Virology
	Oplodiol exhibits noteworthy anti-plasmodial activity against Plasmodium falciparum strains. Oplodiol has a stimulative effect on significantly proliferation and differentiation of culture osteoblasts; it also shows moderate cytotoxic effects on the human
TN1646	Flemiphilippinin A	Others	Others
	Flemiphilippin A has antioxidant activity, it shows DPPH radical scavenging activity with effective half maximal concentration (EC50) of 18.36 ug/mL. Flemiphilippinin A (5 ug/mL) exhibits some level of antitumor activity against human hepatocellular carci
TN5264	Xanthoxyletin	TNF; NOS; ROS; COX; Antifection	Apoptosis; Immunology/Inflammation; Microbiology/Virology; Neuroscience
	Xanthoxyletin shows potent antibacterial, fungicidal, and algicidal properties, it also has anticancer, and anti-inflammatory activities. It shows an inhibitory effect on iNOS protein expression at 10 microM, it also can inhibit the synthesis of nitric oxide and the protein expression of tumor necrosis factor-alpha and cyclooxygenase-2. Xanthoxyletin induces S phase arrest and apoptosis in human gastric adenocarcinoma SGC-7901 cells, the effects are associated with the DNA damage, apoptosis thro...
T81201	Sartorypyrone B
	Sartorypyrone B为Chevalone C的2β-乙酰氧基衍生物，由海绵源真菌Neosartorya tsunodae(KUFC 9213)的培养物中乙酸乙酯提取得到。该化合物对MCF-7、NCI-H460和A375-C5细胞系展示出较强的生长抑制活性，GI50s值分别为17.8、20.5和25.0 μM，显示其在乳腺癌、非小细胞肺癌和黑色素瘤研究中的应用潜力。
T83916	Cytogenin
	Cytogenin（一种源自S. eurocidicum的香豆素衍生物）具有多种生物活性。在每日给药25 mg/kg剂量下，能减轻Ehrlich鼠自发性腺癌模型的肿瘤重量。在体内，Cytogenin（每日30和100 mg/kg）可减少链脲佐菌素诱导的体重下降和血浆葡萄糖水平上升，以及小鼠糖尿病模型中巨噬细胞胰腺浸润。同时，在每日100 mg/kg的剂量下，能降低小鼠巨噬细胞中zymosan和LPS诱导的一氧化氮产生，及LPS诱导的Il-6水平增加。
T36179	Aspulvinone O
	Aspulvinone O is a fungal metabolite that has been found in P. variotti and has antioxidant and anticancer activities.1,2 It scavenges 2,2-diphenyl-1-picrylhydrazyl radicals in a cell-free assay (IC50 = 11.6 μM).1 Aspulvinone O inhibits aspartate transaminase 1 (GOT1; Kd = 3.32 μM) and is cytotoxic to PANC-1, AsPC-1, and SW1990 pancreatic cancer cells (IC50s = 20.54-26.8 μM).2 It reduces the oxygen consumption rate (OCR) and induces apoptosis in SW1990 cells. Aspulvinone O (2.5 and 5 mg/kg) redu...

天然产物

Cat.No: T1166

Synonym: 玫瑰树碱,NSC 71795,Elliptisine

Target: Topoisomerase

Cat.No: TN5086

Target: Others

Cat.No: T36115

Synonym: 3-Demethylcolchicine glucoside

Target: Others

Glucodigifucoside

Cat.No: TN2430

Synonym: 洋地黄毒苷元葡萄糖基岩藻糖苷,洋地黄

Cat.No: T3786

Synonym: lycopersicin,番茄素,番茄碱

Target: Apoptosis, Proteasome

Cat.No: T35673

Synonym: Scopularic acid

Target: Others

Cat.No: T5753

Synonym: 黄卡瓦胡椒素 C,卡瓦胡椒素C

Target: Apoptosis

Cat.No: TN2347

Synonym: 麻醉椒苦素,Methysticin

Target: Others

Cat.No: TN1620

Synonym: 毛萼乙素

Target: Apoptosis, cAMP, NF-κB, STAT

trans-Nerolidol

Cat.No: T36473

Cat.No: T4672

Target: Apoptosis, Anti-infection, JAK, STAT, Autophagy

Cat.No: T7033

Target: Antioxidant, COX

Cat.No: T1660

Synonym: 水飞蓟宾 A,水飞蓟宾,Silibinin A,Silybin,Silymarin I

Target: Reactive Oxygen Species, Autophagy

Cat.No: TMA1841

Target: Others

Cat.No: T3S2016

Target: Others

Cat.No: T70955

Synonym: SM-345431

Target: Phospholipase, Antibacterial

Yunnancoronarin A

Cat.No: TN5274

Target: Others

Cat.No: TN1359

Synonym: 黄曲霉毒素G1,黄曲霉毒素 G1

Target: TNF, NF-κB

Cat.No: TN1872

Target: Others

Cat.No: TN3605

Target: Others

Cat.No: TN1523

Target: Others

Atalantoflavone

Cat.No: TN3465

Target: Antifection

Jatamanvaltrate B

Cat.No: TN4352

Target: Others

Cat.No: TN1464

Target: RAAS

1,4,5,6-Tetrahydroxy-7,8-diprenylxanthone

Cat.No: TN2492

Target: Others

Iriflophenone 2-O-Rhamnoside

Cat.No: TN3870

Synonym: Dimethylmatairesinol

Target: Others

1,4,5,6-Tetrahydroxy-7-prenylxanthone

Cat.No: TN2493

Target: Others

Cat.No: TN4355

Target: Others

1-Decarboxy-3-oxo-ceanothic acid

Cat.No: TN2529

Target: DNA/RNA Synthesis

Chlorovaltrate K

Cat.No: TN3646

Target: Others

Cat.No: T81452

Cat.No: TN5249

Target: Others

3-Hydroxybakuchiol

Cat.No: TN2945

Target: ATPase, Caspase

2,3,23-Trihydroxy-12-oleanen-28-oic acid

Cat.No: TN2684

Target: Others

4',5,7-Trihydroxy-6-prenylflavone

Cat.No: TN3009

Target: Others

Cat.No: TN4716

Target: Influenza Virus

Flemiphilippinin A

Cat.No: TN1646

Target: Others

Cat.No: TN5264

Target: TNF, NOS, ROS, COX, Antifection

Sartorypyrone B

Cat.No: T81201

Cat.No: T83916

Cat.No: T36179

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