610
45
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T24797 |
SK609 HCl
SK-609 HCl,SK609 hydrochloride,SK 609 HCl,SK 609 hydrochloride,SK-609 hydrochloride |
||
SK609 HCl is a selective dopamine D3 receptor agonist. It also has atypical signaling properties. | |||
T12928 |
SK33
|
Androgen Receptor | Endocrinology/Hormones |
SK33 是一种有效的组织选择性抗雄激素药物,是一种肌醇类似物,能够降低雄激素受体 (AR) 的转录活性。 | |||
T34650 |
SK&F 107461
SK&F107461,SK&F-107461 |
||
F 107461 is a hydroxyethylene dipeptide isostere. | |||
T24798 |
SK-7041
SK 7041 |
||
SK-7041 is an effective HDAC inhibitor that acts by preferentially inhibiting class I HDAC1 and HDAC2. | |||
T26191 |
SK&F 104976
SK&F104976,Skf104976,Skf 104976,SK&F-104976,Skf-104976 |
||
SK&F 104976 is a 32-carboxylic acid derivative of lanosterol. It was found to be a potent lanosterol 14 alpha-demethylase (14 alpha DM) inhibitor. | |||
T7524 |
Metiamide
甲硫米特,SK&F 92058 |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Metiamide (SK&F 92058) 是一种组胺H2受体拮抗剂。 | |||
T29067 |
Upacicalcet
PLS-240,SK-1403,AJT-240 |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Upacicalcet (AJT-240) 是一种静脉内拟钙剂,是一种可用于人血液透析的 SHPT, 通过直接作用于甲状旁腺细胞膜钙敏感受体来抑制过量的甲状旁腺激素 (PTH) 分泌,从而降低血液中的 PTH 水平。 3 Upacicalcet 是钙敏感受体的正变构调节剂,可预防大鼠腺嘌呤诱导的继发性甲状旁腺功能亢进模型中的血管钙化和骨骼疾病。 | |||
T26644 |
Apomine
SK&F-99085,APB-231-A2,APB-231-A-2,SR-9223i,SK&F-99085,SR-45023A |
HMG-CoA Reductase | Metabolism |
Apomine (SR-9223i) 是一种 HMG-CoA-还原酶抑制剂,可在体外促进骨髓瘤细胞的凋亡,并与体内骨髓瘤的调节有关。 Apomine 加速 3-羟基-3-甲基戊二酰-CoA 还原酶的降解并刺激低密度脂蛋白受体活性。 Apomine 通过下调 3-羟基-3-甲基戊二酰-CoA 还原酶来增强洛伐他汀对骨髓瘤细胞的抗肿瘤作用。 | |||
T7133 |
Anagliptin
SK-0403,阿拉格列汀 |
Proteasome; DPP-4 | Proteases/Proteasome; Ubiquitination |
Anagliptin (SK-0403) 是一种选择性的二肽酰肽酶 4 抑制剂,IC50=3.8 nM,对 DPP-8/9 的选择性相对较弱,IC50分别为 68 和 60 nM。 | |||
T34651 |
SK&F 108361
Skf-108361,SK&F-108361,Skf 108361,SK&F108361,Skf108361 |
||
SK&F 108361 is a symmetric diol that binds HIV-1 protease symmetrically. | |||
T69596 |
SK-575
|
||
SK-575 is a Highly Potent and Efficacious Proteolysis-Targeting Chimera Degrader of PARP1 for Treating Cancers. SK-575 potently inhibits the growth of cancer cells bearing BRCA1/2 mutations and induces potent and specific degradation of PARP1 in various human cancer cells even at low picomolar concentrations. SK-575 achieves durable tumor growth inhibition in mice when used as a single agent or in combination with cytotoxic agents, such as temozolomide and cisplatin. | |||
T20641 |
Propagermanium
Dipropanoic acid germanium sequioxide,SK-818,Ge 132,二羧乙基三氧化二锗,Ge132,SK 818,Ge-132 |
Others | Others |
Propagermanium (Ge132) 是一种锗的有机金属化合物,在日本已被用作治疗慢性乙型肝炎的药物。 | |||
T34652 |
SK&F 39728-A
SK&F39728-A,SK&F 1-39728,SK&F-39728-A,Skf 39728-A |
||
SK&F 39728-A is a bioactive chemical. | |||
T24795 |
SK&F 103784
Skf 103784,Skf-103784,Skf103784 |
||
SK&F 103784 is a vasopressin antagonist. | |||
TQ0126 |
Mirodenafil dihydrochloride
SK-3530 dihydrochloride,米罗那非二盐酸盐 |
PDE | Metabolism |
Mirodenafil dihydrochloride 是一种磷酸二酯酶5(PDE-5)抑制剂,可作用于勃起功能紊乱的研究。 | |||
T28787 |
SK&F-95601
SK&F 95601,SKF95601,SKF 95601,SKF-95601 |
||
F-95601 is a proton pump inhibitor. | |||
T26190 |
SK&F 106760
SK&,F-106760,SKF 106760,SKF-106760,F106760,SKF106760,F 106760 |
||
SKF 106760 is used as a glycoprotein IIb/IIIa antagonist. | |||
T41273 |
Phen Green SK diacetate
|
||
T28788 |
SK-216
SK216.Plasminogen activator inhibitor-1 (PAI-1) inhibitor |
||
SK-216 is a specific PAI-1 inhibitor. SK-216 reduced the extent of angiogenesis in the tumors and inhibited VEGF-induced migration and tube formation by human umbilical vein endothelial cells in vitro. SK-216 reduced the degree of bleomycin-induced pulmon | |||
T24796 |
SK&F 107260
Skf107260,Skf-107260,Skf 107260 |
||
SK&F 107260 is an RGD-containing peptide. It is a potent GP IIb/IIIa antagonist and a vitronectin antagonist. | |||
T23761 |
Atiprimod dimaleate
SK&F-106615,SK&F 106615,SK&F106615 |
||
Atiprimod Dimaleate is a JAK2 inhibitor. | |||
T35203 |
Xylonidine
SK&F-35866,SK&F35866,SK&F 35866 |
||
Xylonidine is a biochemical. | |||
T70618 |
SK609
|
||
SK609 is a selective dopamine D3 receptor agonist which significantly improves the performance of the impaired paw and normalizes the bilateral asymmetry associated with the hemiparkinson rat. | |||
T70283 |
SK 946
|
||
SK 946 is a cognition activator. | |||
T28796 |
SKI2852
SK I2852,SKI-2852 |
||
SKI2852 is a highly Potent, selective, and orally bioavailable inhibitor of 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1). hHSD1 IC50 = 2.9nM; mHSD1 IC50 = 1.6nM. | |||
T33740 |
NSC 157449
SK&F-83589,SK&F 83589,NSC157449,NSC-157449 |
||
NSC 157449 is a bioactive chemical. | |||
T23883 |
Chlorasquin
Ccnsc-529,861,Ccnsc 529,861,SK 29861,Ccnsc529,861,SK-29861 |
||
Chlorasquin is a dihydrofolate reductase inhibitor. | |||
T74558 |
SK-575-NEG
|
||
SK-575-NEG(化合物28)是SK-575的甲基化对应物,通过对SK-575中的哌啶-2,6-二酮氨基进行甲基化合成而得,用作对照化合物。SK-575-NEG强效结合PARP1,IC50值仅为2.64 nM。在1 μM浓度下,SK-575-NEG对MDA-MB-436和Capan-1细胞中PARP1的降解完全无效。 | |||
T81151 |
SK-MLCK M13
|
||
SK-MLCK M13,作为具生物活性的肽类化合物,代表着钙调蛋白(CaM)靶标蛋白的CAM结合域,其中CaM为广泛存在的Ca2+结合蛋白。 | |||
T16079 |
Mirodenafil
米罗那非,SK3530 |
PDE | Metabolism |
Mirodenafil 是一种磷酸二酯酶5(PDE-5)抑制剂,可用于勃起功能紊乱的研究。 | |||
T25453 |
Glaspimod
F 107647,SK&,F-107647,F107647 |
||
Glaspimod is a synthetic hematoregulatory peptide. It shares biological and/or modulatory activities with natural hematopoetic cytokines. | |||
T33787 |
Olaflur
SKF 38095,GA 297,SK&F 38095 |
||
Olaflur is a compound that prevents dental caries. | |||
T31364 |
Dehydelone
KOS1584,SK-10088,KOS-1584,R-1645,SK10088,R1645 |
||
Dehydelone(KOS-1584, R-1645, SK-10088) is a microtubule stabilizer that may be used in the treatment of non-small cell lung cancer. | |||
T32834 |
Lobendazole
SK&F 24529,SKF 24529,NSC-42044,NSC42044,NSC 42044 |
||
Lobendazole is a metabolite of thiophanate. | |||
T28794 |
SKF-97574 HCl
SKF97574,SKF-97574,B-9937-051,BY 574,SKF 97574,SK&F-97574 |
||
SKF-97574 is proton pump inhibitor. | |||
T68818 |
Icotidine
|
||
Icotidine is an antagonist of histamine at both H1 and H2 receptors. | |||
T34653 | SK1071 | ||
SK1071 is a novel migrastatin analogs, which demonstrated improved performance over migrastatin, with nanomolar IC50 values in chamber cell migration assays with tumor cells and human umbilical vein endothelial cells (HUVECs), and in wound healing assays. | |||
T9033 |
BTYNB
MDK6620,BTYNB IMP1 Inhibitor |
Others; c-Myc; NF-κB | Cell Cycle/Checkpoint; NF-κB; Others |
BTYNB (MDK6620) 是IMP1结合 c-Myc mRNA 的有效选择性抑制剂,IC50为 5 μM。它下调 β-TrCP1 mRNA 并减少NF-κB 的激活。它通过损害 IGF2 mRNA 结合蛋白 1 结合来破坏这种增强子功能,可用于癌症研究。 | |||
T71174 |
PBT434 HBr
|
||
PBT434 is a novel, brain-penetrant, small molecule inhibitor of α-synuclein aggregation. In transgenic animal models of Parkinson disease (A53T) and MSA (PLP-α-Syn), PBT434 reduced α-synuclein aggregation, preserved neurons and improved motor function. Glial cell inclusions were also reduced in a murine MSA model. PBT434 is thought to act by redistributing reactive iron across membranes, thereby blocking intracellular protein aggregation and oxidative stress. The affinity of PBT434 for iron is g... | |||
T70282 |
Drofenine
|
||
Drofenin is an anticonvulsant. It is an anticholinergic that acts both at the level of the nerves and the muscle fibers (neurotropic musculotropic effect). Drofenin also acts as FIASMA (functional inhibitor of acid sphingomyelinase ) | |||
T9522 |
Rimtuzalcap
CAD-1883 |
Potassium Channel | Membrane transporter/Ion channel |
Rimtuzalcap (CAD-1883) 是首创的,选择性的小电导钙激活钾通道 (SK 通道) 正变构调节剂。Rimtuzalcap 可用于运动障碍的研究,包括脊髓小脑性共济失调 (SCA)和特发性震颤 (ET)。 | |||
T70616 |
ACT-672125
|
||
ACT-672125 is a Potent CXCR3 Antagonist with Therapeutic Potential in Autoimmune Diseases. ACT-672125 showed good physicochemical properties and safety profile. In a proof-of-mechanism model of lung inflammation, ACT-672125 inhibited the recruitment of CXCR3 expressing T cells into the inflamed lung in a dose-dependent manner. | |||
T68587 | Oxmetidine mesylate | ||
Oxmetidine mesylate is an antagonist to Histamine H2 Receptors | |||
T12927 | SK1-IN-1 | S1P Receptor | GPCR/G Protein |
SK1-IN-1 is a potent inhibitor of sphingosine kinase 1 (SPHK1)(IC50 of 58 nM). | |||
T70252 |
RU1968 bis-TFA salt
|
||
RU1968 bis-TFA salt is an inhibitor of the sperm-specific Ca2+ channel CatSper, thereby inhibiting human Slo3 with about 15-fold lower potency than CatSper. | |||
T60798 |
SK1- I hydrochloride
|
||
SK1-I hydrochloride (BML-258 hydrochloride) 是鞘氨醇类似物,能够增强细胞自噬并显示抗癌活性。SK1-I hydrochloride 是同工酶特异性SPHK1竞争抑制剂 (Ki = 10 μM)。 | |||
T61605 |
SK3 Channel-IN-1
|
||
SK3 Channel-IN-1 (compound 7a) is a powerful and selective modulator of the SK3 channel. It demonstrates significant efficacy in inhibiting breast cancer MDA-MB-435 cell migration while maintaining low cytotoxicity in other cell lines. Furthermore, SK3 Channel-IN-1 exhibits the ability to modulate ion channel activity in cancer cells [1]. | |||
T30485 |
SK1-I
BML 258,BML-258,BML258,BML-258 HCl |
||
BML-258 HCl was removed and discontinued. | |||
T8461 |
SKI V
|
Apoptosis; PI3K; S1P Receptor | Apoptosis; GPCR/G Protein; PI3K/Akt/mTOR signaling |
SKI V 是一种非竞争性非脂质鞘氨醇激酶抑制剂,对 GST-hSK 的IC50为 2 μM。 它减少有丝分裂的第二信使鞘氨醇-1-磷酸的形成,可诱导细胞凋亡并具有抗肿瘤活性。它还抑制PI3K,对 hPI3k 的IC50为 6 μM。 | |||
T6673 |
SKI II
SphK-I2 |
Apoptosis; Wnt/beta-catenin; S1P Receptor | Apoptosis; Cytoskeletal Signaling; GPCR/G Protein; Stem Cells |
SKI II (SphK-I2) 是一种口服有效的合成鞘氨醇激酶 (SK)抑制剂,抑制 SK1 和 SK2,IC50值分别为 78 μM 和 45 μM。它通过诱导溶酶体/蛋白酶体降解,不可逆地抑制SK1。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T2218 |
8-Azaguanine
Azaguanine-8,SK 1150,8-氮鸟嘌呤,NSC-749,SF-337 |
Nucleoside Antimetabolite/Analog; Others; Endogenous Metabolite | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Others |
8-Azaguanine (SK 1150) 是一种具有潜在抗肿瘤活性的嘌呤类似物。它易于掺入核糖核酸中,干扰正常的生物合成途径,从而抑制细胞生长,可作为抗代谢药。 | |||
T75634 | Demycarosyl-3D-β-D-digitoxosylmithramycin SK | ||
Demycarosyl-3D-β-D-digitoxosylmithramycin SK 为Mithramycin类似物,展现出显著的抗肿瘤活性。该化合物通过与DNA结合蛋白结合并抑制其功能,有效阻断肿瘤细胞的增殖与生长。 | |||
TN1520 |
Isoforskolin
Coleonol B |
IL Receptor; TNF | Apoptosis; Immunology/Inflammation |
Isoforskolin 源自毛喉鞘蕊花,可减少人单核白细胞中 TNF-α、IL-1β、IL-6 和 IL-8 的分泌。Isoforskolin 可用于治疗莱姆关节炎的研究。 | |||
TN1040 |
Skullcapflavone II
|
COX; Antibacterial; TGF-beta/Smad | Immunology/Inflammation; Microbiology/Virology; Neuroscience; Stem Cells |
Skullcapflavone II 是从黄芩中提取的黄酮,具有抗炎作用。它对 M. aurum 和 M. bovisBCG 具有较强的抗菌活性。它还调节破骨细胞的分化、存活和功能。 | |||
T2939 |
Forskolin
毛喉素,Coleonol,Colforsin |
FXR; Adenylyl cyclase; AChR; Autophagy | Autophagy; Metabolism; Neuroscience |
Forskolin (Coleonol) 属于天然产物,是一种腺苷酸环化酶激活剂 (EC50=0.5 μM)。Forskolin 可以增加 cAMP 水平,可以激活 PXR 和 FXR,也可以诱导细胞自噬。Forskolin 对心脏产生正性肌力作用,具有血小板抗凝集和降压作用。 | |||
T3869 |
Skimmin
茵芋苷,Skimmine |
Others | Others |
Skimmin (Skimmine) 是一种香豆素类物质。存在于圆锥绣球中,能够抑制免疫复合物的沉积,具有抗炎作用。 | |||
T5654 |
Musk ketone
|
Others | Others |
Musk ketone 可诱导癌细胞生长抑制和凋亡。它增加谷胱甘肽 S-转移酶的活性,因此可能被证明是有用的癌症化学保护剂。 | |||
T2S2109 |
Skimmianine
beta-Fagarine,Skimmianin,茵芋碱,Chloroxylonine,Skimmiamine |
Others | Others |
Skimmianine (Chloroxylonine) 是一种呋喹啉类生物碱,主要存在于芸香科,具有抗炎、抗痉挛和抗血小板聚集活性。它对多种癌细胞系具有细胞毒性和基因毒性。 | |||
T5281 |
Skatole
粪臭素,Scatole,3-Methylindole,3-Methylindole,3-甲基吲哚,3-Methyl-1H-indole,beta-Methylindole |
AhR; p38 MAPK; Aryl Hydrocarbon Receptor; Endogenous Metabolite; Antibacterial; Autophagy; Antifungal | Autophagy; Immunology/Inflammation; MAPK; Metabolism; Microbiology/Virology |
Skatole (3-Methyl-1H-indole) 是由肠道菌群产生的,通过激活芳基烃受体和 p38调节肠上皮细胞功能。 | |||
TN2112 |
Przewalskinic acid A
|
Others | Others |
Przewalskinic acid A is a rare, water-soluble, and highly biologically active ingredient found, thus far, only in the Salvia przewalskii Maxim herb. | |||
TN4827 |
Preskimmianine
|
Others | Others |
Preskimmianine is the biogenetic precursor of skimmianine.It can significantly inhibit nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated BV2 cells. | |||
TN6197 | 8,8''-Biskoenigine | ||
8,8''-Biskoenigine 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN6197,CAS号为 477890-82-7。 | |||
TN4835 |
Przewalskin
|
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Przewalskin A and Przewalskin B showed modest anti-HIV-1 activity with EC50 = 41 and 30 microg/mL, respectively. | |||
TN1001 | Apiosylskimmin | Others | Others |
Apiosylskimmin is a natural product from Angelica gigas. | |||
T16160 |
Musk tibetene
Musk tibetine |
Others | Others |
Musk tibetine reveals no genotoxicity in the micronucleus test with human lymphocytes and human hepatoma cell lines. Musk tibetene is a nitro musk compound with carcinogenic activity. | |||
T75545 | PCSK9-IN-9 | ||
PCSK9-IN-9 是一种天然来源的异香豆素。PCSK9-IN-9 可抑制原蛋白转化酶枯草菌素 kexin 型 9 (PCSK9)、IDOL 和 SREBP2的 mRNA 表达水平。PCSK9-IN-9 抑制 PCSK9的 IC50为 11.9 μM。 | |||
TN4073 | Forskolin G | Others | Others |
Forskolin is known to elevate intracellular cAMP levels. | |||
TN5019 |
Siegeskaurolic acid
|
TNF; NOS; NF-κB; COX; NO Synthase; Prostaglandin Receptor | Apoptosis; GPCR/G Protein; Immunology/Inflammation; Neuroscience; NF-κB |
Siegeskaurolic acid 是一种具有抗炎活性的天然产物。 | |||
TN4074 |
Forskolin J
|
Others | Others |
Forskolin J 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN4074,CAS号为 81873-08-7。 | |||
TN5033 |
Skullcapflavone I
|
IL Receptor; Caspase; Prostaglandin Receptor | Apoptosis; GPCR/G Protein; Immunology/Inflammation; Proteases/Proteasome |
Skullcapflavone I has anti-inflammatory and anti-allergic potential, it can significantly inhibit LPS stimulated NO and PGE(2) release in J774A.1 macrophages and inhibit LPS induced IL-6 production in a concentration dependent manner. Skullcapflavone I se | |||
T3S1589 |
Notoginsenoside Fa
|
Others | Others |
Notoginsenoside Fa 是一种原人参二醇型皂苷,从P. notoginseng 提取出来得到,有激活和恢复退化脑功能的潜能。 | |||
TN2256 |
Taccalonolide B
根薯酮内酯B,根薯酮内酯 B |
Microtubule Associated | Cytoskeletal Signaling |
Taccalonolide B 是从广西裂果薯中分离得到的一种微管稳定剂,具有抗肿瘤活性。它抑制 SK-OV-3 细胞的生长,IC50 为 208 nM,在体外对过表达 P-糖蛋白 (Pgp) 和多药耐药蛋白 (MRP7) 的细胞系有效。 | |||
TN1516 |
Cnidicin
蛇床素,4,9-双[(3-甲基-2-丁烯-1-基)氧基]-7H-呋喃并[3,2-G][1]苯并吡喃-7-酮 |
NOS; NO Synthase | Immunology/Inflammation |
Cnidicin 是一种香豆素,对肥大细胞脱颗粒及 RAW 264.7 细胞产生一氧化氮具有抑制作用。 | |||
TN2097 |
Pomolic acid
坡模酸 |
Apoptosis; Caspase; HIV Protease; AMPK | Apoptosis; Chromatin/Epigenetic; Microbiology/Virology; PI3K/Akt/mTOR signaling; Proteases/Proteasome |
Pomolic acid 是从野鸦椿中分离出来的一种五环三萜烯。它抑制肿瘤细胞的生长,诱导细胞凋亡,有用于前列腺癌的潜力。 | |||
TN2254 |
Taccalonolide A
根薯酮内酯A,根薯酮内酯 A |
Apoptosis; Microtubule Associated | Apoptosis; Cytoskeletal Signaling |
Taccalonolide A 是从水田七根茎中分离得到的一种类固醇,具有细胞毒性和抗疟活性。它在体外对过表达 p 糖蛋白、多药耐药蛋白 7 细胞系有抑制作用,抑制 SK-OV-3 细胞生长的 IC50值为 622 nM。它是微管稳定剂,能引起 G2-M 期滞留、Bcl-2 磷酸化,并引发细胞凋亡。 | |||
T2850 |
Bicuculline
荷包牡丹碱,(+)-Bicuculline,d-Bicuculline |
GABA Receptor | Membrane transporter/Ion channel; Neuroscience |
Bicuculline ((+)-Bicuculline) 是从东北延胡索中提取的一种生物碱,能阻断 Ca2+激活钾 (SK) 通道。它是一种竞争性的神经递质 GABAA 受体拮抗剂,IC50为 2 μM。 | |||
T6S1487 |
Ginsenoside Rg5
人参皂苷Rg5,人参皂甙 Rg5 |
NF-κB; COX; IGF-1R | Immunology/Inflammation; Neuroscience; NF-κB; Tyrosine Kinase/Adaptors |
Ginsenoside Rg5 是红参的主要成分,可阻断IGF-1与其受体的结合,IC50约为90 nM。它还通过抑制NF-κB p65的 DNA 结合活性来抑制COX-2的 mRNA 表达。它可促进血管生成和改善高血压,具有抗炎和治疗阿尔茨海默病的潜力。 | |||
T3932 |
Viscidulin I
|
Others | Others |
Viscidulin I 存在于黄芩中,是一种天然产物。 | |||
TN2666 |
1alpha-Hydroxytorilin
|
Others | Others |
1alpha-Hydroxytorilin exhibits cytotoxicity against human A549, SK-OV-3, SK-MEL-2, and HCT15 tumor cells. | |||
TN4959 | Schizandriside | Prostaglandin Receptor | GPCR/G Protein; Immunology/Inflammation |
Schizandriside may have anti-inflammatory effects, it has inhibitory activities against nitric oxide and prostaglandin E(2) production in IFN-γ- and lipopolysaccharide-stimulated RAW 264.7 cells. It shows significant cytotoxicity against A549, SK-OV-3, SK | |||
TN4373 | Kaempferol tetraacetate | Antifection | Microbiology/Virology |
Kaempferol tetraacetate is a potent antiplatelet agent. It exhibits significant cytotoxicity in vitro against three human cell lines HL-60, U937 and SK-MEL-1. | |||
TN3832 |
Deoxyflindissone
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Others | Others |
Deoxyflindissone exhibits significant cytotoxic activity against the A549, SK-OV-3, SK-MEL-2, and XF498 cell lines. | |||
TN2669 |
1beta-Hydroxytorilin
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Others | Others |
1beta-Hydroxytorilin exhibits cytotoxicity against human A549, SK-OV-3, SK-MEL-2, and HCT15 tumor cells. | |||
T82298 |
Glucozaluzanin C
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Glucozaluzanin C,一种木脂素类化合物,由菊科鸢尾根的MeOH提取物中分离得到,显示出对多种细胞系具有显著的生物活性。具体而言,其在A549、SK-OV-3、SK-MEL-2、XF498和HCT15细胞上的ED50值依次为2.45 μg/mL、1.37 μg/mL、0.40 μg/mL、1.41 μg/mL、1.43 μg/mL。 | |||
TN6014 |
Norcepharadione B
鱼腥草 |
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Norcepharadione B shows good inhibitory activity against the replication of HSV-1, it also shows antimalarial activity with EC50 values of 7.5mug/ml. Norcepharadione B exhibits significant cytotoxicity against five human tumor cell lines (A-549, SK-OV-3, | |||
TN3007 | 4,4'-Dihydroxy-3,3',9-trimethoxy-9,9'-epoxylignan | Others | Others |
4,4'-Dihydroxy-3,3',9-trimethoxy-9,9'-epoxylignan shows cytotoxic activities against four tumor cell lines (A549, SK-OV-3, SKMEL-2 and HCT15). | |||
TN4146 | Glutinol acetate | TNF | Apoptosis |
Glutinol acetate shows significant cytotoxic activity against four human cancer cell lines (HL-60, SK-OV-3, A549, and HT-29), with GI(50) in the range of 11.1-17.9microM; it also has anti-inflammatory effect, exhibits moderate inhibitory activity of TNF-alpha secretion in the lipopolysaccharide (LPS)-stimulated murine RAW264.7 macrophage cell line. | |||
TN3862 | Dihydroprehelminthosporol | Others | Others |
Dihydroprehelminthosporol is a strongly phytotoxic metabolite, it exhibits cytotoxicity towards two human cancer cell lines, A549 and SK-OA-3. | |||
T37543 |
Anhydroepiophiobolin A
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Anhydroepiophiobolin A is a sesterterpenoid fungal metabolite that has been found in B. oryzae. It is cytotoxic to HepG2 and K562 cells (IC50s = 47.1 and 35.6 μM, respectively) as well as A549, SKOV3, SK-MEL-2, XF498, and HCT15 cells (IC50s = 1.6-1.9 μg/ml). Anhydroepiophiobolin A is phytotoxic to S. viridis and D. erucoides in a leaf puncture assay. | |||
T83597 |
(+)-Menthyl acetate
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(+)-Menthyl acetate是一种从Cunila angustifolia Benth精油中分离得到的化学化合物。它对MCF-7细胞株具有较高的选择性,其半抑制浓度(IC50)为34.0 μg/mL,而对SK-Mel-28细胞株的选择性较低,IC50为279.9 μg/mL,并且对A549细胞没有致死作用。 | |||
T35483 |
19,20-Epoxycytochalasin D
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19,20-Epoxycytochalasin D is a fungal metabolite that has been found in the endophytic fungus Nemania sp. UM10M. It is active against the chloroquine-sensitive and -resistant strains of P. falciparum (MIC = 0.4 ng/ml for both) without inducing cytotoxicity in Vero cells. It is cytotoxic to BT-549, LLC-PK11, and P388 cells (IC50s = 7.84, 8.4, and 0.16 µM, respectively) but not SK-MEL, KB, or SKOV3 cells up to a concentration of 10 µM. | |||
TN2977 |
3-O-trans-p-Coumaroyltormentic acid
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Caspase; Antifection | Apoptosis; Microbiology/Virology; Proteases/Proteasome |
3-O-(E)-p-coumaroyl tormentic acid may be promising lead compound for developing an effective drug for treatment of leukemia, it induces apoptotic cell death in human leukemia (HL60) via mainly mitochondrial pathway by, at least in part, Topo I inhibition. 3-O-trans-p-coumaroyltormentic acid shows cytotoxicity against four human tumor cell lines (A549, SK-OV-3, SK-MEL-2, and HCT-15) in vitro, the IC50 values of 13.72, 14.29,14.61, 14.04 uM, respectively. 3beta-O-cis-p-Coumaroyltormentic acid, an... | |||
T37452 |
Stephacidin B
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Stephacidin B is a fungal metabolite that has been found inA. ochraceus.1Dimeric stephacidin B is rapidly converted to a monomer, avrainvillamide ,in vitro.2Stephacidin B is cytotoxic to a variety of cancer cells, including testosterone-independent PC3 and -sensitive LNCaP prostate cancer cells (IC50s = 0.37 and 0.06 μM, respectively) and estradiol-independent SK-BR-3 and -sensitive MCF-7 breast cancer cells (IC50s = 0.32 and 0.27 μM, respectively).1It induces apoptosis in HepG2 and Huh7 hepatoc... | |||
T36749 |
Herboxidiene
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Herboxidiene is a polyketide originally isolated from S. chromofuscus that has diverse biological activities.[1],[2,][3],[4],[5] It inhibits growth of HeLa S3, SK-MEL-2, PC3, A549, and EBC-1 cells with GI50 values ranging from 7.4 to 62 nM.3 Herboxidiene is cytostatic against human umbilical vein endothelial cells (HUVECs; (IC50 = 26 nM)) and inhibits VEGF-induced invasion and tube formation of serum-starved HUVECs in a concentration-dependent manner, indicating antiangiogenic activity.[4] Herbo... | |||
T36954 |
Nemorosone
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Nemorosone is a polycyclic polyprenylated acylphloroglucinol (PPAP) originally isolated from C. rosea that has antiproliferative properties.1 Nemorosone inhibits growth of NB69, Kelly, SK-N-AS, and LAN-1 neuroblastoma cells (IC50s = 3.1-6.3 μM), including several drug-resistant clones, but not MRC-5 human embryonic fibroblasts (IC50 = >40 μM).2 It increases DNA fragmentation in LAN-1 cells in a dose-dependent manner, and decreases N-Myc protein levels and phosphorylation of ERK1/2 by MEK1/2. Nem... |