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48

抑制剂 & 化合物

17

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T17208	USL311	CXCR	Autophagy; GPCR/G Protein; Immunology/Inflammation
	USL311 是选择性 CXCR4拮抗剂，可防止基质细胞衍生因子 1（SDF-1 或 CXCL12）与 CXCR4 结合。它抑制 CXCR4 活化并减少表达 CXCR4 的肿瘤细胞的增殖和迁移，具有抗肿瘤活性。
T17158	trans-AUCB t-AUCB	Epoxide Hydrolase	Metabolism
	trans-AUCB (t-AUCB) 是口服具有活力的、选择性的可溶性环氧水解酶 (sEH) 抑制剂，对人，小鼠和大鼠的 sEH 的IC50分别为 1.3 nM，8 nM，8 nM。它具有抗神经胶质瘤特性。
T14214	AMG 511	PI3K	PI3K/Akt/mTOR signaling
	AMG 511 是一种高效的、口服有效的 I 类 pan-PI3K 抑制剂，对 PI3Kα, β, δ 和 γ 作用的 Ki 值分别为 4 nM, 6 nM, 2 nM 和 1 nM。它它显著抑制了 PI3K 信号，减少 p-Akt (Ser473)。它在小鼠胶质母细胞瘤移植瘤模型中具有抗肿瘤作用。
T8742	G5-7 JAK2 inhibitor G5-7	Apoptosis; JAK	Angiogenesis; Apoptosis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	JAK2 inhibitor G5-7 (JAK2 inhibitor G5-7) 是具有口服活性的JAK2变构抑制剂，可通过结合到 JAK2，选择性的抑制JAK2介导的 EGFR 和 STAT3 的磷酸化和激活。它诱导细胞周阻滞和诱导凋亡、具有抗血管生成活性。它有用于胶质瘤研究的潜能。
T3213	Hematoporphyrin dihydrochloride 血卟啉二盐酸盐,Hematoporphyrin IX dihydrochloride	Apoptosis; Others; Endogenous Metabolite	Apoptosis; Metabolism; Others
	Hematoporphyrin dihydrochloride (Hematoporphyrin IX dihydrochloride) 是一种光敏剂，是血红素结合蛋白亲和色谱底物。它暴露在红光下时，可诱导 U87 胶质瘤细胞凋亡，并降低体内肿瘤的生长。
T6920	ON123300	FGFR; c-RET; JAK; CDK; PDGFR; Src; AMPK	Angiogenesis; Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; JAK/STAT signaling; PI3K/Akt/mTOR signaling; Stem Cells; Tyrosine Kinase/Adaptors
	ON123300 是一种可透过血脑屏障的多激酶抑制剂，作用于 CDK4、CDK6、Ark5、PDGFRβ、FGFR1、RET 和 Fyn，IC50值为3.9、9.82、5、26、26、9.2和11 nM。它在脑肿瘤中抑制 Akt 磷酸化及激活 Erk。
T2028	NG 52 NG52,NG-52,Compound 52	CDK	Cell Cycle/Checkpoint
	NG 52 (NG-52) 是可逆和 ATP 相容性且具有口服活性的Cdc28p 和Pho85p 激酶抑制剂，IC50分别为 7 μM 和 2 μM。它还抑制磷酸甘油酸激酶 1 的活性，IC50值为 2.5 μM。
T1944	LDN-214117	ALK; TGF-beta/Smad	Angiogenesis; Stem Cells; Tyrosine Kinase/Adaptors
	LDN214117 是一种高效的 ALK2 选择性抑制剂(IC50:22nM)，也是一种 BMP6 抑制剂(IC50:100nM)，对ALK5抑制力弱100倍。
T1158	Phenoxybenzamine hydrochloride 苯氧苯札明,NCI-c01661,NSC 37448,盐酸酚苄明,Phenoxybenzamine HCl	CaMK; Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Phenoxybenzamine hydrochloride (NCI-c01661) 是一种选择性的 α-adrenoceptor 和 calmodulin 的抑制剂，是常用的抗高血压药。
T23480	U-83836E	Others	Others
	U-83836E (lazaroid ) 具有神经保护活性和抗肿瘤活活性，抑制神经胶质瘤细胞增殖，抑制肿瘤坏死因子并逆转内毒素诱导的休克。
T7008	Vacquinol-1 Vacquinol 1	JNK	MAPK
	Vacquinol-1 能够激活 MAPK 通路，是MKK4特异性激活剂。它可以诱导肝细胞癌细胞凋亡，在多形性胶质母细胞瘤小鼠模型中特异性诱导人胶质母细胞瘤细胞死亡、减缓肿瘤进展并延长生存期。
T61051	ANO1-IN-1	Chloride channel	Membrane transporter/Ion channel
	ANO1-IN-1是一种选择性的 ANO1 通道阻断剂，对 ANO1 和 ANO2有抑制作用， IC50 值分别为 2.56 μM 和 15.43 μM。ANO1-IN-1 对胶质瘤细胞的增殖抑制作用显著。
T14126	ADDA 5 hydrochloride	Others	Others
	ADDA 5 hydrochloride is a partial non-competitive inhibitor of cytochrome c oxidase (CcO). For purified CcO from human glioma and bovine heart, the IC50s are 18.93 μM and 31.82 μM , respectively.
T28173	NIK-250 NIK250
	NIK-250 is a P-glycoprotein inhibitor. NIK250 could reverse multidrug resistance in human glioma cells.
T28048	Mivobulin Isethionate NSC-613863,CI-980,NSC-635370,NSC-613862,NSC-350386
	Mivobulin is a tubulin inhibitor potentially for the treatment of glioma, malignant melanoma, prostate, ovarian cancer. CI-980 acts at the colchicine-binding site.
T26493	AA 863 AA-863
	AA 863 is a 5-lipoxygenase inhibitor, it inhibits the proliferation of human glioma cell lines in dose-dependent.
T28195	NS004 NS 004,NS-004
	NS004 is a large-conductance K+ channel opener, it inhibits mitochondrial function in glioma cells.
T21842	2-fluoro Palmitic Acid
	2-Fluoropalmitic acid, 是一种酰基辅酶 A 合成酶抑制剂，是一种候选的抗神经胶质瘤的药物。 2-Fluoropalmitic acid 抑制胶质瘤干细胞 (GSC) 活力和干细胞样表型。 2-Fluoropalmitic acid 还抑制神经胶质瘤细胞系的增殖和侵袭。
T24920	UCD38B HCl UCD38B hydrochloride,UCD 38 B hydrochloride,UCD-38-B HCl,UCD-38-B Hydrochloride,UCD 38 B HCl
	UCD38B HCl is a cell-permeable intracellular uPA inhibitor that acts by killing proliferative and non-proliferative high-grade glioma cells by programmed necrosis.
T68324	KCN1
	KCN1, a novel synthetic sulfonamide, is a HIF pathway inhibitor with potential anticancer activity in vitro and in vivo anti-pancreatic cancer activities and preclinical pharmacology. KCN1 specifically inhibited HIF reporter gene activity in several glioma cell lines at the nanomolar level. KCN1 also downregulated transcription of endogenous HIF-1 target genes, such as VEGF, Glut-1, and carbonic anhydrase 9, in a hypoxia-responsive element (HRE)-dependent manner. KCN1 potently inhibited the grow...
TP1589	EGFRvIII peptide (PEPvIII) EGFRvIII peptide PEPvIII
	PEPvIII, a peptide sequence from EGFRvIII, was designed to represent a target of glioma and is presented by MHC I/II complexes.
T60661	CP681301
	CP681301 是CDK5的有效抑制剂，具有抗增殖活性。CP681301 在果蝇中表现出抗肿瘤活性。CP681301 降低神经胶质瘤干细胞中 CD133、OLIG2、SOX2、KI67、pCDK5 蛋白水平的表达。CP681301 减少小鼠胶质瘤异种移植物的自我更新。
T36407	Pyrrolidine Ricinoleamide
	Ricinoleic acid is a naturally occurring 12-hydroxy fatty acid. It constitutes about 90% of the fatty acids in castor oil. Pyrrolidine Ricinoleamide is a derivative of the amide of ricinoleic acid that shows potent antiproliferative activity against an array of cancer cell lines, including human glioma U251 cells.
T38970	Hematoporphyrin monomethyl ether
	Hematoporphyrin monomethyl ether (HMME), a second-generation porphyrin-related photosensitizer, is a highly selective and low-toxicity compound known for its singular form and high yield of singlet oxygen. It finds extensive application in diagnosing and treating various tumors, including lung cancer, bladder cancer, nevus flammeus, and brain glioma.
T74365	Chol-CTPP
	Chol-CTPP是针对血脑屏障(BBB)与胶质瘤(glioma)细胞展现双重靶向性的配体，可以与Chol-TPP合成为Lip-CTPP。Lip-CTPP作为一种潜在载体，可用于联合阿霉素(DOX)和氯胺达明(LND)发挥抗胶质瘤(anti-glioma)效果。此载体能够增强对肿瘤细胞的增殖、迁移及侵袭抑制，同时促进细胞凋亡(apoptosis)与坏死(necrosis)，并干扰线粒体功能。
T41212	FTI 277
	FTI 277 is a prodrug form of FTI 276 that inhibits farnesyltransferase (FTase) (IC50 = 0.5 nM). Inhibits H-Ras and K-Ras processing in whole cells (IC50 values are 0.1 and 10μM respectively) and disrupts constitutive H-Ras-specific activation of MAPK. Causes significant antiproliferative effects in human malignant glioma cells and many other tumor cell lines.
T61958	MAO A/HDAC-IN-1
	MAO A/HDAC-IN-1 是有效的单胺氧化酶 A (MAO A) 和HDAC 双重抑制剂，可用于胶质瘤研究。
T35558	KAAD-Cyclopamine
	Cyclopamine-KAAD is a potent inhibitor of hedgehog signaling with an IC50 value of 20 nM in a Shh-LIGHT2 assay. It blocks binding of BODIPY-cyclopamine to cells expressing Smoothened (Smo) in a dose-dependent manner. Cyclopamine-KAAD is cell-permeable and binds to SmoA1 to promote its exit from the endoplasmic reticulum. It inhibits the invasion and migration (45.9 and 43.3% inhibition, respectively) of Bel-7402 hepatocarcinoma cells and decreases the expression of nuclear glioma-associated onco...
T36042	17(R)-HDHA
	Resolvins are a group of polyhydroxylated metabolites of docosahexaenoic acid (DHA) found in the inflammatory exudates of aspirin-treated experimental animals. 17(R)-HDHA is the primary oxygenation product of DHA when exposed to aspirin-inhibited cyclooxygenase-2. 17(R)-HDHA serves as a precursor to resolvins and has intrinsic biological activity, such as the inhibition of TNFα-induced IL-1β expression in human glioma cells.
T36449	(S)-α-Methylbenzyl Ricinoleamide
	(S)-α-Methylbenzyl ricinoleamide is a fatty acid amide derived from ricinoleic acid and methyl benzylamine. It demonstrates potent growth inhibition of glioma (U251), breast (MCF-7), ovarian (NCI-ADR/RES and OVCAR-3), kidney (786-0), non-small cell lung (NCI-H460), and prostate (PC-3) cancer cells with a mean GI50 value of 6.9 μM.
T77112	Onfekafusp alfa
	Onfekafusp alfa（L19TNF）是一款将工程化的L19抗体scFv与人TNF融合所得的同源三聚体。该化合物主要应用于恶性胶质瘤的研究。
TP1935	RAGE antagonist peptide
	Receptor for advanced glycation end products (RAGE) antagonist. Blocks S100P, S100A4 and HMGB-1 mediated RAGE activation in vitro and in vivo. Inhibits growth and metastasis of rat glioma tumors. Reduces cell growth and RAGE-mediated NF-κB activity in hum
T36406	Pyrrolidine Linoleamide
	Linoleic acid is an essential fatty acid and one of the most abundant polyunsaturated fatty acids in the western diet. Pyrrolidine Linoleamide is a derivative of the amide of linoleic acid that shows potent antiproliferative activity against an array of cancer cell lines, including human glioma U251 cells. It is greater than 4-fold more effective against cancer cells than non-cancer cells.
T41204	TAT-Gap19(I130A) TAT-Gap19(I130A)
	TAT-Gap19(I130A) is a control peptide for TAT-Gap19, a Cx43 hemichannel blocker. TAT-Gap19(I130A) consists of TAT-GAP19 with a I130A amino acid residue change at a key residue for GAP19 activity. In C6 glioma cells expression Cx43, TAT-GAP19(1130A) does not inhibit [Ca2+]i-triggered ATP release at 200 μM. TAT-Gap19(I130A) is cell permeable.
T8792	SMBA1
	SMBA1 是一种 Bax 激活因子，是一种有效的 Bax 激动剂（Ki ：43.3 nM），诱导恶性胶质瘤细胞周期阻滞和凋亡。SMBA1 有增强 Bax 表达的作用，显示出抗肿瘤活性。SMBA1 可用于研究癌症。
T36323	C8 Galactosylceramide (d18:1/8:0) C8 Galactosylceramide (d18:1/8:0)
	C8 Galactosylceramide is a synthetic C8 short-chain derivative of known membrane microdomain-forming sphingolipids. It increases the amount delivered and toxicity of doxorubicin in cancerous but not non-cancerous cells when incorporated into the nanoliposomal membrane of nanoliposomal-doxorubicin. C8 Galactosylceramide induces proliferation and cytokine production by splenocytes in vitro at concentrations ranging from 100-1,000 ng/ml but has no effect on natural killer T cell production in vivo....
T62364	CSF1R-IN-5
	CSF1R-IN-5 是一种 CSF1R 的有效抑制剂。其中 CSF-1R 表达于巨噬细胞中，巨噬细胞的存活和分化依赖于 CSF-1/CSF-1R 信号通路。CSF1R-IN-5 可以影响 TAM 和胶质瘤细胞之间炎症因子的交换。CSF1R-IN-5 具有潜力进行癌症疾病的研究。
T35947	17(S)-HDHA
	17(S)-HDHA is a primary mono-oxygenation product of docosahexaenoic acid in human whole blood, human leukocytes, and mouse brain. 17(S)-HDHA serves as a precursor to 17(S)-resolvins and has intrinsic biological activity, such as the inhibition of TNF-α-induced interleukin-1β expression in human glioma cells and inhibition of TNF-α-induced leukocyte trafficking to the mouse air pouch.
T35542	LLP-3
	Survivin (also known as baculoviral IAP repeat-containing protein 5 (BIRC5)) is a member of the inhibitor of apoptosis (IAP) family that interacts with and inhibits the apoptotic function of several proteins. LLP-3 is a cell-permeable ligand of Survivin that blocks its interaction with Ran, resulting in the induction of apoptosis (IAP) in glioma stem cells (IC50 = 31 μM). It abolishes the growth of glioblastoma multiforme cell in spheres and in tumor slice cultures.
T37431	ENPP1 Inhibitor C ENPP1 Inhibitor C
	ENPP1 inhibitor C is an inhibitor of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1; IC50 = 0.26 μM in a cell-free assay).1 It is selective for ENPP1 over ENPP2-7 at 10 μM. ENPP1 inhibitor C decreases ENPP1 activity in MDA-MB-231 human breast and C6 rat glioma cancer cells when used at a concentration of 10 μM. \|1. Kawaguchi, M., Han, X., Hisada, T., et al. Development of an ENPP1 fluorescence probe for inhibitor screening, cellular imaging, and prognostic assessment of malignant brea...
T62725	IDH1 Inhibitor 5
	IDH1 Inhibitor 5 (compound 2) 是一种 IDH1（异柠檬酸脱氢酶 1）的抑制剂。IDH1 Inhibitor 5 能够抑制 MOG 细胞 (IC50: 64.4 nM) 以及表达外源突变 IDH1 R132H 蛋白的野生型 IDH1 胶质瘤细胞 (IC50: 34.9 nM)。
T78124	SF2312 ammonium	Antibiotic	Microbiology/Virology
	SF2312铵是SF2312的铵盐形式，后者为一种膦酸盐类抗生素兼烯醇酶抑制剂。该化合物可从放线菌小单孢菌分离而得，在缺氧环境中活性显著。SF2312对ENO1基因缺失的神经胶质瘤细胞显示出选择性毒杀作用。
T78877	MTX-241F	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	MTX-241F是一种选择性小分子抑制剂，针对EGFR和PI3激酶家族。其具备穿透血脑屏障的能力，能够持续控制肿瘤生长。在来源于患者的DIPG神经球中，MTX-241F展示了与放射疗法协同增效的特性，适用于研究弥漫性内源性桥脑胶质瘤(DIPG)。
T62342	CSF1R-IN-4
	CSF1R-IN-4 是一种 CSF-1R 的有效抑制剂。其中 CSF-1R 表达于巨噬细胞中，巨噬细胞的存活和分化依赖于 CSF-1/CSF-1R 信号通路。CSF1R-IN-4 能够影响 TAM 和胶质瘤细胞之间炎症因子的交换。CSF1R-IN-4 具有潜力进行癌症疾病的研究。
T35573	Adenosine 5’-methylenediphosphate (hydrate)
	Adenosine 5’-methylenediphosphate is an inhibitor of ecto-5’-nucleotidase, also known as CD73, with a Kivalue of 37 nM.1It inhibits cAMP accumulation induced by adenosine 5’-monophosphate , adenosine 5’-diphosphate , or adenosine 5’-triphosphate but not adenosine in VA-13 human fibroblasts when used at a concentration of 100 μM. Adenosine 5’-methylenediphosphate reduces proliferation of U138MG glioma cells, as well as inhibits the invasion and migration of MHCC97H hepatocellular carcinoma (HCC) ...
T78450	4-Di-1-ASP
	4-Di-1-ASP是一种苯乙烯基染料，适用于标记活脑组织中的神经胶质瘤细胞，常用于分析细胞的结构、活性、增殖以及内吞作用、胞吐和吞噬作用。同时，该染料也被用于观察活细胞的线粒体结构。在显微镜观察下，4-Di-1-ASP能够发射绿色荧光（λex/λem= 475/606 nm）。
T82049	IR-Crizotinib	NF-κB	NF-κB
	IR-Crizotinib是一种结合了近红外染料IR-786和Crizotinib的复合物，能穿透血脑屏障及在小鼠颅内荧光定位GBM。作为NIK抑制剂，其IC50值为3.381 μM，既能有效抑制胶质瘤细胞体外生长及侵袭，也适用于体内研究，对癌症治疗具有研究意义。
T83741	S7 TFA Leu-Ser-Leu-Iso-Thr-Arg-Leu-OH
	S7是一种IL-6受体的肽类拮抗剂，能够浓度依赖性地抑制IL-6与IL-6受体的结合。在C-33 A宫颈癌细胞和RPMI-8226 B细胞淋巴细胞中，S7 (50 µM) 能抑制IL-6诱导的VEGF水平增加。在每两天给药一次，剂量为50 mg/kg的条件下，S7能减少IL-6过表达的C-33 A宫颈癌小鼠异种移植模型中的肿瘤体积。当S7与半胱氨酸结合，并连接到包裹多柔比星的脂质纳米粒子(LNPs)表面时，能增强LNPs对胶质瘤的靶向性，并在U251胶质母细胞瘤小鼠异种移植模型中提高生存率。

化合物

Cat.No: T17208

Target: CXCR

Cat.No: T17158

Synonym: t-AUCB

Target: Epoxide Hydrolase

Cat.No: T14214

Target: PI3K

Cat.No: T8742

Synonym: JAK2 inhibitor G5-7

Target: Apoptosis, JAK

Hematoporphyrin dihydrochloride

Cat.No: T3213

Synonym: 血卟啉二盐酸盐,Hematoporphyrin IX dihydrochloride

Target: Apoptosis, Others, Endogenous Metabolite

Cat.No: T6920

Target: FGFR, c-RET, JAK, CDK, PDGFR, Src, AMPK

Cat.No: T2028

Synonym: NG52,NG-52,Compound 52

Target: CDK

Cat.No: T1944

Target: ALK, TGF-beta/Smad

Phenoxybenzamine hydrochloride

Cat.No: T1158

Synonym: 苯氧苯札明,NCI-c01661,NSC 37448,盐酸酚苄明,Phenoxybenzamine HCl

Target: CaMK, Adrenergic Receptor

Cat.No: T23480

Target: Others

Cat.No: T7008

Synonym: Vacquinol 1

Target: JNK

Cat.No: T61051

Target: Chloride channel

ADDA 5 hydrochloride

Cat.No: T14126

Target: Others

Cat.No: T28173

Synonym: NIK250

Mivobulin Isethionate

Cat.No: T28048

Synonym: NSC-613863,CI-980,NSC-635370,NSC-613862,NSC-350386

Cat.No: T26493

Synonym: AA-863

Cat.No: T28195

Synonym: NS 004,NS-004

2-fluoro Palmitic Acid

Cat.No: T21842

Cat.No: T24920

Synonym: UCD38B hydrochloride,UCD 38 B hydrochloride,UCD-38-B HCl,UCD-38-B Hydrochloride,UCD 38 B HCl

Cat.No: T68324

EGFRvIII peptide (PEPvIII)

Cat.No: TP1589

Synonym: EGFRvIII peptide PEPvIII

Cat.No: T60661

Pyrrolidine Ricinoleamide

Cat.No: T36407

Hematoporphyrin monomethyl ether

Cat.No: T38970

Cat.No: T74365

Cat.No: T41212

MAO A/HDAC-IN-1

Cat.No: T61958

KAAD-Cyclopamine

Cat.No: T35558

Cat.No: T36042

(S)-α-Methylbenzyl Ricinoleamide

Cat.No: T36449

Onfekafusp alfa

Cat.No: T77112

RAGE antagonist peptide

Cat.No: TP1935

Pyrrolidine Linoleamide

Cat.No: T36406

TAT-Gap19(I130A)

Cat.No: T41204

Synonym: TAT-Gap19(I130A)

Cat.No: T8792

C8 Galactosylceramide (d18:1/8:0)

Cat.No: T36323

Synonym: C8 Galactosylceramide (d18:1/8:0)

Cat.No: T62364

Cat.No: T35947

Cat.No: T35542

ENPP1 Inhibitor C

Cat.No: T37431

Synonym: ENPP1 Inhibitor C

IDH1 Inhibitor 5

Cat.No: T62725

SF2312 ammonium

Cat.No: T78124

Target: Antibiotic

Cat.No: T78877

Target: EGFR

Cat.No: T62342

Adenosine 5’-methylenediphosphate (hydrate)

Cat.No: T35573

Cat.No: T78450

Cat.No: T82049

Target: NF-κB

Cat.No: T83741

Synonym: Leu-Ser-Leu-Iso-Thr-Arg-Leu-OH

Cat. No.	Product Name	Target	Signaling Pathways
T4S0094	Hydroxygenkwanin 羟基芫花素,Luteolin 7-methylether,7-O-Methylluteolin	Antioxidant	oxidation-reduction
	Hydroxygenkwanin (Luteolin 7-methylether) 是一种丁香达芙妮的主要成分，是一种天然的类黄酮化合物。它具有抗氧化，抗神经胶质瘤能力和抗癌作用。
TN1933	Mitraphylline 帽柱木菲碱,帽柱叶碱	IL Receptor; TNF; NF-κB	Apoptosis; Immunology/Inflammation; NF-κB
	Mitraphylline 是一种绒毛钩藤中主要的五环吲哚类生物碱，可阻碍脂多糖介导的原代人中性粒细胞活化。
TN2326	(Z)-Butylidenephthalide (Z)-3-Butylidenephthalide	Glucosidase	Metabolism
	(Z)-Butylidenephthalide ((Z)-3-Butylidenephthalide) 具有抗肿瘤和降血糖作用，能有效抑制胶质瘤的肿瘤生长，抑制 R-葡萄糖苷酶活性。
TN2175	Salvianolic acid F 丹酚酸F,丹酚酸 F	Caspase	Apoptosis; Proteases/Proteasome
	The role of our hybrid molecules, an analogue of Salvianolic acid F, in compelling the glioma cells towards apoptosis by specifically perturbing the concentration of glutathione along with caspase 6.
T7131	Antineoplaston A10 3-苯基乙酰氨基-2,6-哌啶二酮,NSC-648539	Apoptosis; Endogenous Metabolite; Ras	Apoptosis; GPCR/G Protein; MAPK; Metabolism
	Antineoplaston A10 (NSC-648539) 是存在于人体内的一种天然产物，可研究胶质瘤、淋巴瘤、星形细胞瘤和乳腺癌，是一种 Ras 抑制剂。
T2945	Germacrone	P450; Antiviral; Influenza Virus	Immunology/Inflammation; Metabolism; Microbiology/Virology
	Germacrone 提取自姜黄，具有抗炎、抗雄激素和抗病毒活性。它还通过促进细胞凋亡来抑制胶质瘤细胞的增殖。
TN2285	DL-Tryptophan (±)-Tryptophan,Tryptophan,DL-色氨酸	Serotonin Transporter; Endogenous Metabolite	Metabolism; Neuroscience
	DL-Tryptophan ((±)-Tryptophan) 是内源性代谢产物的一种。
T6S0325	Glycitein 黄豆黄素,Glycetein	Apoptosis; Others	Apoptosis; Others
	Glycitein (Glycetein) 是一种大豆异黄酮，可研究抗氧化和细胞凋亡。
TN1068	Tricin	Others; CDK	Cell Cycle/Checkpoint; Others
	Tricin 是米糠中大量存在的一种天然类黄酮。它通过抑制 CDK9 来抑制HCMV 的复制。它通过上调 FAK 靶向 microRNA-7 的表达来抑制 C6 胶质瘤细胞的增殖和侵袭。
T4928	L-Kynurenine L-犬尿氨酸,(S)-Kynurenine	AhR; Aryl Hydrocarbon Receptor; Endogenous Metabolite	Immunology/Inflammation; Metabolism
	L-Kynurenine ((S)-Kynurenine) 是L-色氨酸的代谢物，是芳香烃受体激动剂，可抑制同种异体 T 细胞增殖并增加恶性 U87 神经胶质瘤细胞侵入胶原基质。
TN2063	Physalin B NSC-287088	Apoptosis; NF-κB; Akt; PI3K; Nrf2; NOD	Apoptosis; Cytoskeletal Signaling; Immunology/Inflammation; NF-κB; PI3K/Akt/mTOR signaling
	Physalin B 是茄科植物的主要活性化合物之一，具有广泛的生物活性，可用于治疗炎症湿疹和疱疹等疾病。Physalin B 通过激活 PI3K/Akt 通路抑制 NF-κB 和 NLRP3，从而改善脂多糖诱导的急性肺损伤造成的炎症反应。Physalin B 通过激活 Nrf2 通路抑制 PDGF-BB 诱导的 VSMC 增殖、迁移和表型转化。Physalin B 通过抑制 LAP2α-HDAC1 介导的胶质瘤相关癌基因 1 的去乙酰化和肝星状细胞活化来发挥抗肿瘤活性。
T72904	Norswertianin
	Norswertianin，一种氧杂蒽酮类化合物，有效抗神经胶质瘤化合物(anti-glioma compound)。通过氧化应激和Akt/mTOR依赖自噬，诱导GBM细胞分化。
T82273	Gochnatiolide A
	Gochnatiolide A是从Ainsliaea henryi中提取的一种二聚倍半萜烯，对肾脏、黑色素瘤、卵巢抵抗和神经胶质瘤细胞系显示出抗增殖活性。
T21577	Narasin (sodium salt) Naracin sodium salt,naransin sodium,海南霉素,HainanMycin	NF-κB	NF-κB
	Narasin (sodium salt) (HainanMycin) 通过神经胶质瘤细胞中的 ER 应激诱导肿瘤坏死因子相关凋亡诱导配体 (TRAIL) 介导的细胞凋亡，并通过抑制 IκBα 的磷酸化来抑制 NF-κB 信号传导。
T10910	Cycloartenol	Others	Others
	Cyclopentanol is a plant sterol compound and one of the key precursors for biosynthesis of various sterol compounds. Cycloartenol inhibits the migration of glioma cells and inhibits the phosphorylation of p38 MAP kinase. Cycloenol has various pharmacologi
TN4838	Pseurotin A	Antifection	Microbiology/Virology
	Pseurotin A has immunosuppressive activity, it inhibits immunoglobulin E(IgE) production in vitro.It shows a moderate effect against the phytopathogenic bacteria Erwinia carotovora and Pseudomonas syringae, with IC50 values of 220 and 112 microg ml(-1), r
T8199	(±)-α-Bisabolol Bisabolol	Apoptosis; Antioxidant	Apoptosis; oxidation-reduction
	(±)-α-Bisabolol (Bisabolol) 是一种从洋甘菊、念珠菌树等植物精油中提取的倍半萜烯醇，是一种天然防腐剂，具有舒缓、抗刺激、抗炎、抗氧化和抗癌活性。(±)-α-Bisabolol 通过诱导细胞周期停滞、线粒体死亡和抑制 PI3K/Akt 信号通路来发挥作用，对 A549 NSC-LC 细胞产生抗癌作用 (IC50 = 15 μM)。(±)-α-Bisabolol 能强效诱导胶质瘤细胞凋亡。

天然产物

Hydroxygenkwanin

Cat.No: T4S0094

Synonym: 羟基芫花素,Luteolin 7-methylether,7-O-Methylluteolin

Target: Antioxidant

Cat.No: TN1933

Synonym: 帽柱木菲碱,帽柱叶碱

Target: IL Receptor, TNF, NF-κB

(Z)-Butylidenephthalide

Cat.No: TN2326

Synonym: (Z)-3-Butylidenephthalide

Target: Glucosidase

Salvianolic acid F

Cat.No: TN2175

Synonym: 丹酚酸F,丹酚酸 F

Target: Caspase

Antineoplaston A10

Cat.No: T7131

Synonym: 3-苯基乙酰氨基-2,6-哌啶二酮,NSC-648539

Target: Apoptosis, Endogenous Metabolite, Ras

Cat.No: T2945

Target: P450, Antiviral, Influenza Virus

Cat.No: TN2285

Synonym: (±)-Tryptophan,Tryptophan,DL-色氨酸

Target: Serotonin Transporter, Endogenous Metabolite

Cat.No: T6S0325

Synonym: 黄豆黄素,Glycetein

Target: Apoptosis, Others

Cat.No: TN1068

Target: Others, CDK

Cat.No: T4928

Synonym: L-犬尿氨酸,(S)-Kynurenine

Target: AhR, Aryl Hydrocarbon Receptor, Endogenous Metabolite

Cat.No: TN2063

Synonym: NSC-287088

Target: Apoptosis, NF-κB, Akt, PI3K, Nrf2, NOD

Cat.No: T72904

Gochnatiolide A

Cat.No: T82273

Narasin (sodium salt)

Cat.No: T21577

Synonym: Naracin sodium salt,naransin sodium,海南霉素,HainanMycin

Target: NF-κB

Cat.No: T10910

Target: Others

Cat.No: TN4838

Target: Antifection

(±)-α-Bisabolol

Cat.No: T8199

Synonym: Bisabolol

Target: Apoptosis, Antioxidant

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