Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ADDA 5 hydrochloride is a partial non-competitive inhibitor of cytochrome c oxidase (CcO). For purified CcO from human glioma and bovine heart, the IC50s are 18.93 μM and 31.82 μM , respectively.
产品描述 | ADDA 5 hydrochloride is a partial non-competitive inhibitor of cytochrome c oxidase (CcO). For purified CcO from human glioma and bovine heart, the IC50s are 18.93 μM and 31.82 μM , respectively. |
靶点活性 | CcO (human glioma):18.93 μM, CcO (bovine heart):31.82 μM |
体外活性 | ADDA 5 hydrochloride is a partial non-competitive inhibitor of CcO, with IC50s of 18.93 μM and 31.82 μM for purified CcO from human glioma and bovine heart, respectively. ADDA 5 inhibits CcO activity in UTMZ and Jx22-derived GSCs, with IC50s of 21.4 ± 3.9 μM and 15.5 ± 2.8 μM. ADDA 5 (25 μM) shows a growth inhibitory effect on UTMZ cells, with an EC50 of 8.17 μM[1]. |
体内活性 | ADDA 5 does not causes detectable toxicity at up to 80 mg/kg in mice[1]. ADDA 5 (8 mg/kg, i.p.) obviously suppresses the growth of tumor in mice. |
分子量 | 406 |
分子式 | C24H36ClNO2 |
CAS No. | 473268-46-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 65 mg/mL (160.10 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.4631 mL | 12.3153 mL | 24.6305 mL | 61.5764 mL |
5 mM | 0.4926 mL | 2.4631 mL | 4.9261 mL | 12.3153 mL | |
10 mM | 0.2463 mL | 1.2315 mL | 2.4631 mL | 6.1576 mL | |
20 mM | 0.1232 mL | 0.6158 mL | 1.2315 mL | 3.0788 mL | |
50 mM | 0.0493 mL | 0.2463 mL | 0.4926 mL | 1.2315 mL | |
100 mM | 0.0246 mL | 0.1232 mL | 0.2463 mL | 0.6158 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
ADDA 5 hydrochloride 473268-46-1 Others ADDA5 Hydrochloride ADDA 5 Hydrochloride ADDA-5 Hydrochloride Inhibitor inhibitor inhibit