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Search Results for " fgfr1 "

Targets Recommended: Discoidin Domain Receptor (DDR) FGFR Others

97

抑制剂 & 化合物

3

天然产物

28

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T11279	FGFR1/DDR2 inhibitor 1	Discoidin Domain Receptor (DDR); FGFR; Others	Angiogenesis; Others; Tyrosine Kinase/Adaptors
	FGFR1/DDR2 inhibitor 1 是一种具有口服活性的成纤维细胞生长因子受体 1 和盘状蛋白域受体 2 的抑制剂，能够抑制 FGFR1 (IC50:31.1 nM) 和 DDR2 (IC50:3.2 nM)，具有抗肿瘤作用。
T39992	FGFR1 inhibitor-2 FGFR1 inhibitor-2
	FGFR1 inhibitor-2 (with an IC50 of 4.55 μM in MDA-MB-231 cells) is a potent inhibitor of FGFR1. It is specifically useful for studying metastatic triple-negative breast cancer.
T78830	FGFR1 inhibitor 7	FGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	FGFR1 inhibitor7（compound 5），作为一种FGFR1络氨酸激酶抑制剂，具有0.33 nM的IC50。它对多种人癌细胞系显示出广谱的细胞毒性，能在2.1 μM的IC50抑制MOLT3细胞系。
T78832	FGFR1 inhibitor-9	FGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	FGFR1inhibitor-9（Compound 9），一种FGFR1抑制剂（IC50为0.85 nM），可与FGFR1的ATP结合袋发生结合，并展现出抗癌活性。
T63816	FGFR1 inhibitor-6
	FGFR1 inhibitor-6 是 FGFR1 的有效抑制剂 (IC50: 16.31 nM)，具有细胞毒活性。FGFR1 inhibitor-6 能够将细胞周期阻滞在前 G1 和 G2/M 期并诱导细胞凋亡 (apoptosis) 。
T79686	FGFR1 inhibitor-10	FGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	FGFR1inhibitor-10 (Compound 4i)为一种选择性的FGFR1抑制剂，其IC50值为28 nM。该化合物有效阻断FGFR1磷酸化，并展现出了明显的抗血管生成和抗侵袭特性，具有潜在的抗肿瘤效果。
T78831	FGFR1 inhibitor-8	FGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	FGFR1inhibitor-8（化合物9）是一种高效的FGFR1抑制剂，其IC50s为0.5 nM，能够与FGFR1的ATP结合口袋发生相互作用，并显示出抗癌活性。
T78845	FGFR1/VEGFR2-IN-1	VEGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	FGFR1/VEGFR2-IN-1 (compound 2b) 为FGFR1/VEGFR2抑制剂，适用于癌症研究。
T9030	SU4984	FGFR; IGF-1R; PDGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	SU4984 是蛋白质酪氨酸激酶抑制剂，能够抑制成纤维细胞生长因子受体 1 (FGFR1) (IC50:10-20 μM)，还能够抑制血小板衍生的生长因子受体和胰岛素受体的活性。它可用于研究癌症。
T6920	ON123300	FGFR; c-RET; JAK; CDK; PDGFR; Src; AMPK	Angiogenesis; Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; JAK/STAT signaling; PI3K/Akt/mTOR signaling; Stem Cells; Tyrosine Kinase/Adaptors
	ON123300 是一种可透过血脑屏障的多激酶抑制剂，作用于 CDK4、CDK6、Ark5、PDGFRβ、FGFR1、RET 和 Fyn，IC50值为3.9、9.82、5、26、26、9.2和11 nM。它在脑肿瘤中抑制 Akt 磷酸化及激活 Erk。
T2372	Ponatinib 帕纳替尼,AP24534,普纳替尼	VEGFR; FGFR; Bcr-Abl; PDGFR; Src; c-Kit; Autophagy	Angiogenesis; Autophagy; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	Ponatinib (AP24534) 是一种有口服活性的多靶点激酶抑制剂，抑制Abl、PDGFRα、VEGFR2、FGFR1和Src 的IC50分别为 0.37 nM、1.1 nM、1.5 nM、2.2 nM 和 5.4 nM。
T23127	PD-161570 PD 161570	EGFR; FGFR; PDGFR; Src	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	PD-161570 是一种有效的 ATP 竞争性人 FGF-1 受体抑制剂，IC50 为 39.9 nM，Ki 为 42 nM。它还是骨形态发生蛋白 (BMPs) 和TGF-β信号抑制剂。它抑制PDGF 刺激的自磷酸化和FGF-1受体磷酸化，IC50分别为 450 和 622 nM。它抑制 PDGFR、EGFR 和 c-Src 酪氨酸激酶，IC50 值分别为 310、240 和 44 nM。
T6479	Dovitinib lactate hydrate Dovitinib (TKI258) Lactate,多韦替尼,Dovitinib Lactate,TKI258	VEGFR; FGFR; FLT; PDGFR; c-Kit	Angiogenesis; Tyrosine Kinase/Adaptors
	Dovitinib lactate hydrate (TKI258) 是一种多靶点的酪氨酸激酶抑制剂，抑制 FLT3，c-Kit，FGFR1/3，VEGFR1/2/3和 PDGFRα/β的 IC50值分别为 1，2，8/9，10/13/8，27/210 nM。
T6082	SSR128129E SSR	FGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	SSR128129E (SSR) 是一种变构和口服活性 FGFR1 抑制剂 (IC50:1.9 μM)，但不影响其他相关的 RTK。
T2642	PD173074	Apoptosis; EGFR; VEGFR; FGFR; IGF-1R; Src	Angiogenesis; Apoptosis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	PD173074 是一种 FGFR1抑制剂，IC50为 25 nM。它也可抑制 VEGFR2活性，IC50值为 100-200 nM。
T4318	EOC317 ACTB-1003,ACTB1003,ACTB 1003	VEGFR; FGFR; Tie-2	Angiogenesis; Tyrosine Kinase/Adaptors
	EOC317 (ACTB-1003) 是一种口服可用的激酶抑制剂，能够抑制 FGFR1 (IC50:6 nM)，VEGFR2 (IC50:2 nM) 和 Tie-2 (IC50:4 nM)。
T3726	Erdafitinib 厄达替尼,JNJ-42756493	Apoptosis; FGFR	Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors
	Erdafitinib (JNJ-42756493) 是一种喹喔啉衍生物，是一种具有口服活性的FGFR 家族抑制剂，抑制FGFR1/2/3/4活性的IC50分别为1.2、 2.5、3.0和5.7 nM。
T6996	SU 5402 SU5402	VEGFR; FGFR; PDGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	SU 5402 是多靶点受体酪氨酸激酶抑制剂，能够抑制VEGFR2 (IC50:20 nM)，FGFR1 (IC50:30 nM)，PDGFRβ (IC50:510 nM)。
T1948	AZD4547	VEGFR; FGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	AZD4547 是FGFR 家族抑制剂，能够作用于FGFR1 (IC50:0.2 nM)，FGFR2 (IC50:2.5 nM)，FGFR3 (IC50:1.8 nM) 和FGFR4 (IC50:165 nM)。
T16364	Infigratinib phosphate NVP-BGJ398 phosphate,BGJ-398 phosphate	FGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	Infigratinib phosphate (BGJ-398 phosphate) 是 FGFR 抑制剂，对 FGFR1，FGFR2 和 FGFR3 的 IC50 分别为0.9，1.4 和 1 nM，比对 FGFR4 和 VEGFR2 的抑制性高40倍，对 Abl，Fyn，Kit，Lck 和 Lyn 几乎无活性。
T22306	DGY-06-116	FGFR; Src	Angiogenesis; Tyrosine Kinase/Adaptors
	DGY-06-116 是一种选择性和不可逆的 Src 和 FGFR1 共价抑制剂，IC50 值分别为 3nM 和 8340 nM。
TQ0015	PRN1371	c-Fms; FGFR; CSF-1R	Angiogenesis; Tyrosine Kinase/Adaptors
	PRN1371 是一种高效的、选择性的FGFR1-4和CSF1R 抑制剂，对FGFR1，FGFR2，FGFR3，FGFR4 和 CSF1R 的IC50值分别为 0.6，1.3，4.1，19.3 和 8.1 nM。
T15185	Lucitanib E-3810,德立替尼	VEGFR; FGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	Lucitanib (E-3810) 是 VEGFR 和 FGFR 的双重抑制剂，有效和选择性地抑制VEGFR1 (IC50:7 nM)，VEGFR2 (IC50:25 nM)，VEGFR3 (IC50:10 nM)，FGFR1 (IC50:17.5 nM)，FGFR2 (IC50:82.5 nM)。
T1975	Infigratinib BGJ-398,NVP-BGJ398	Apoptosis; FGFR	Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors
	Infigratinib (NVP-BGJ398) 是一种 FGFR 家族抑制剂，抑制 FGFR1，FGFR2，FGFR3和 FGFR4的 IC50分别为 0.9 nM，1.4 nM，1 nM，60 nM。
T6836	FIIN-2	FGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	FIIN2 是一种 FGFR 的不可逆抑制剂，能够抑制 FGFR1 (IC50:3.1 nM)，FGFR2 (IC50:4.3 nM)，FGFR3 (IC50:27 nM) 和 FGFR4 (IC50:45 nM)。
T3274	S49076	FGFR; c-Met/HGFR; TAM Receptor	Angiogenesis; Tyrosine Kinase/Adaptors
	S49076 是一种新型 MET、AXL/MER 和 FGFR1/2/3 高效抑制剂，IC50<20 nM。
TQ0228	Derazantinib ARQ-087	FGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	Derazantinib (ARQ-087) 是一种有效的，ATP 竞争型的，具有口服活性的酪氨酸激酶抑制剂，能够抑制软骨细胞FGFR1 (IC50:4.5 nM)、FGFR2 (IC50:1.8 nM)、FGFR3 (IC50:4.35nM)。
T5466	Tyrosine kinase-IN-1	VEGFR; FGFR; FLT; PDGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	Tyrosine kinase-IN-1是一种多靶点酪氨酸激酶抑制剂，能够抑制KDR (IC50:4 nM)，Flt-1 (IC50:20 nM)，FGFR1 (IC50:4 nM) 和 PDGFRα (IC50:2 nM)。
T12401	Pemigatinib INCB054828	FGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	Pemigatinib (INCB054828) 是一种口服具有活力的，选择性的 FGFR 抑制剂，能够作用于 FGFR1 (IC50:0.4 nM)，FGFR2 (IC50:0.5 nM)，FGFR3 (IC50:1.2 nM)，FGFR4 (IC50:30 nM)，有用于胆管癌的潜力。
T6024	Zoligratinib FF284,CH5183284,Debio 1347	FGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	Zoligratinib (CH5183284) 是一种口服具有活力的，选择性的FGFR 抑制剂，能够抑制FGFR1 (IC50:9.3 nM)，FGFR2 (IC50:7.6 nM)，FGFR3 (IC50:22 nM)，FGFR4 (IC50:290 nM)。
T8976	PD-089828	EGFR; FGFR; PDGFR; Src	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	PD-089828 是受体酪氨酸激酶 FGFR1、PDGFRβ 和 EGFR 的竞争性抑制剂，IC50分别为0.15、1.76 和 5.47 µM。它也是非受体酪氨酸激酶 c-Src 的非竞争性抑制剂，IC50 为 0.18 µM。
T1777	Nintedanib BIBF 1120,Intedanib,尼达尼布	VEGFR; FGFR; FLT; PDGFR; Src	Angiogenesis; Tyrosine Kinase/Adaptors
	Nintedanib (Intedanib) 是一种三重血管激酶抑制剂，抑制 VEGFR1、VEGFR2、VEGFR3 (IC50=34/13/13 nM)，FGFR1、FGFR2、FGFR3 (IC50=69/37/108 nM)，PDGFRα、PDGFRβ (IC50=59/65 nM)。Nintedanib 具有抗肿瘤活性，通过抑制血管生成来抑制肿瘤生长。
T2358	ENMD-2076	Apoptosis; VEGFR; FGFR; FLT; c-RET; PDGFR; Src; Aurora Kinase	Angiogenesis; Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Tyrosine Kinase/Adaptors
	ENMD2076是一种多靶点激酶抑制剂，抑制Aurora A、Flt3、KDR/VEGFR2、Flt4/VEGFR3、FGFR1、FGFR2、Src、PDGFRα的IC50值分别为1.86、14、58.2、15.9、92.7、70.8、20.2 and 56.4 nM。
T5001	Nintedanib esylate Intedanib,乙磺酸尼达尼布,BIBF 1120 (esylate),尼达尼布乙磺酸盐,Nintedanib Ethanesulfonate Salt,BIBF 1120	VEGFR; FGFR; PDGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	Nintedanib esylate (BIBF 1120 esylate) 是一种有效的三重血管激酶抑制剂，能够抑制 VEGFR1 (IC50:34 nM)、VEGFR2 (IC50:13 nM)、VEGFR3 (IC50:13 nM)，FGFR1 (IC50:69 nM)、FGFR2 (IC50:37 nM)、FGFR3 (IC50:108 nM)，PDGFRα (IC50:59 nM)、PDGFRβ (IC50:65 nM)。
T3466	FIIN-3	EGFR; FGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	FIIN-3 是FGFR 的不可逆抑制剂，对FGFR1、FGFR2、FGFR3和FGFR4的IC50值分别为13.1、21、31.4和35.3 nM。
T3492	PD-166866 PD166866	FGFR; Autophagy	Angiogenesis; Autophagy; Tyrosine Kinase/Adaptors
	PD-166866是一种选择性FGFR1酪氨酸激酶抑制剂，IC50值为52.4 nM。
T5473	ASP5878 ASP-5878	FGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	ASP5878 是一种 FGFR 1 (IC50:0.47 nM)、FGFR 2 (IC50:0.6 nM)、FGFR 3 (IC50:0.74 nM)、和 FGFR 4 (IC50:3.5 nM)的抑制剂，具有口服活性，具有潜在的抗肿瘤作用。
T6338	PHA-680632 PHA 680632,PHA680632	FGFR; PLK; Aurora Kinase	Angiogenesis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Tyrosine Kinase/Adaptors
	PHA-680632 是一种极光激酶抑制剂，对极光激酶 A、B 和C 的IC50值分别为 27、135和 120 nM。它对 FGFR1、FLT3、LCK、PLK1、STLK2 和 VEGFR2/3 的 IC50 高 10 到 200 倍。
T61304	FGFR2-IN-1	FGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	FGFR2-IN-1是一种 FGFR 抑制剂，对 FGFR1、FGFR2和FGFR3具有抑制作用， IC50 分别为460、140和2200 nM。FGFR2-IN-1 可用于研究与 FGFR2 相关的癌症。
T2361	LY2874455 LY 2874455,LY-2874455	VEGFR; FGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	LY2874455 是pan-FGFR 抑制剂，能够抑制FGFR1 (IC50:2.8 nM)，FGFR2 (IC50:2.6 nM)，FGFR3 (IC50:6.4 nM)，FGFR4 (IC50:6 nM)。
T6289	Dovitinib TKI258,多韦替尼,CHIR-258,度维替尼	VEGFR; FGFR; FLT; PDGFR; c-Kit	Angiogenesis; Tyrosine Kinase/Adaptors
	Dovitinib (CHIR-258) 是一种口服有效的、多靶点的酪氨酸激酶 (RTK) 抑制剂，具有抗肿瘤作用。
T0520	Lenvatinib 仑伐替尼,E7080	VEGFR; FGFR; c-RET; PDGFR; c-Kit	Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors
	Lenvatinib (E7080) 是一种多靶点受体酪氨酸激酶抑制剂，抑制 VEGFR1-3、FGFR1-4、KIT、PDGFR 和 RET 等，具有口服活性。Lenvatinib 对 VEGFR2 和 VEGFR3 的抑制活性最强 (IC50=4/5.2 nM)。Lenvatinib 具有强效抗肿瘤活性。
T8541	Lenvatinib mesylate 仑伐替尼甲酸盐,E7080 (mesylate),乐伐替尼	VEGFR; FGFR; c-RET; PDGFR; c-Kit	Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors
	Lenvatinib mesylate (E7080 (mesylate)) 是一种口服具有活力的，多靶点酪氨酸激酶抑制剂，能够抑制血管内皮生长因子受体(VEGFR1-3)，成纤维细胞生长因子受体(FGFR1-4)，干细胞因子受体(KIT)，血小板衍生生长因子受体(PDGFR)，转染期间重排(RET)，具有效抗癌作用。
TQ0317	R1530 R-1530,R 1530	VEGFR; FGFR; FLT; PDGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	R1530 是一种多激酶抑制剂，具有抗肿瘤和抗血管生成活性。它是具有口服活性的有丝分裂/血管生成高效双重作用抑制剂，抑制 VGFR2、FGFR1作用的 IC50分别为 10 nM 和 28 nM。
T4075	Sulfatinib KDR-IN-1,索凡替尼	VEGFR; FGFR; HER	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Sulfatinib (KDR-IN-1) (HMPL-012) 是一种有效且高度选择性的酪氨酸激酶抑制剂，可抑制VEGFR1/2/3，FGFR1和CSF1R，IC50范围为1 到 24 nM 之间。
T6184	Orantinib SU6668,TSU-68,NSC 702827	Apoptosis; VEGFR; FGFR; PDGFR	Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors
	Orantinib (NSC 702827) 是一种多靶点受体酪氨酸激酶抑制剂，对 Flt-1、PDGFRβ和FGFR1的Ki 值分别为 2.1 μM、8 nM 和 1.2 μM。
T2372L	Ponatinib Hydrochloride AP 24534,AP-24534 Hydrochloride,AP-24534,Ponatinib hydrochloride,AP24534 Hydrochloride,AP24534	VEGFR; FGFR; PDGFR; Src	Angiogenesis; Tyrosine Kinase/Adaptors
	Ponatinib Hydrochloride (AP-24534 Hydrochloride) 是 ponatinib 的盐酸盐。Ponatinib 是一种有效的，具有口服活性的多靶点激酶抑制剂，抑制 Abl，PDGFRα，VEGFR2，FGFR1 和 Src 的 IC50 分别为 0.37 nM、1.1 nM、1.5 nM、2.2 nM 和 5.4 nM。
T36680	SM1-71	Serine/threonin kinase; MAPK; LIM Kinase; TGF-beta/Smad; AAK1 (AP2 associated kinase 1)	Cell Cycle/Checkpoint; MAPK; Metabolism; Neuroscience; Stem Cells
	SM1-71 是一种有效的多靶点丙烯酰胺修饰的 TAK1 抑制剂，抑制 MKNK2、MAP2K1/2/3/4/6/7、GAK、AAK1、BMP2K、MAP3K7、MAPKAPK5、GSK3A/B、MAPK1/3、SRC、YES1、FGFR1、ZAK (MLTK)、MAP3K1、LIMK1 和 RSK2。SM1-71 可作为激酶探针，具有抗癌活性，抑制多种癌细胞系的增殖。
T14363	AZ-23 AZ 23,AZ23	Trk receptor	Tyrosine Kinase/Adaptors
	AZ-23是一种 ATP-竞争性的，口服具有活性的 Trk 激酶 A/B/C 抑制剂，IC50值分别为2 nM (TrkA)，8 nM (TrkB)，24 nM (FGFR1)，52 nM (Flt3)，55 nM (Ret)，84 nM (MuSk)，99 nM (Lck)。
T2341	KW-2449 KW2449	Apoptosis; FGFR; FLT; JAK; Bcr-Abl; Src; c-Kit; Aurora Kinase	Angiogenesis; Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
	KW-2449是一种多靶点激酶抑制剂，对FLT3，ABL，ABLT315I 和极光激酶的IC50值分别为6.6，14，4 和 48 nM。

化合物

FGFR1/DDR2 inhibitor 1

Cat.No: T11279

Target: Discoidin Domain Receptor (DDR), FGFR, Others

FGFR1 inhibitor-2

Cat.No: T39992

Synonym: FGFR1 inhibitor-2

FGFR1 inhibitor 7

Cat.No: T78830

Target: FGFR

FGFR1 inhibitor-9

Cat.No: T78832

Target: FGFR

FGFR1 inhibitor-6

Cat.No: T63816

FGFR1 inhibitor-10

Cat.No: T79686

Target: FGFR

FGFR1 inhibitor-8

Cat.No: T78831

Target: FGFR

FGFR1/VEGFR2-IN-1

Cat.No: T78845

Target: VEGFR

Cat.No: T9030

Target: FGFR, IGF-1R, PDGFR

Cat.No: T6920

Target: FGFR, c-RET, JAK, CDK, PDGFR, Src, AMPK

Cat.No: T2372

Synonym: 帕纳替尼,AP24534,普纳替尼

Target: VEGFR, FGFR, Bcr-Abl, PDGFR, Src, c-Kit, Autophagy

Cat.No: T23127

Synonym: PD 161570

Target: EGFR, FGFR, PDGFR, Src

Dovitinib lactate hydrate

Cat.No: T6479

Synonym: Dovitinib (TKI258) Lactate,多韦替尼,Dovitinib Lactate,TKI258

Target: VEGFR, FGFR, FLT, PDGFR, c-Kit

Cat.No: T6082

Synonym: SSR

Target: FGFR

Cat.No: T2642

Target: Apoptosis, EGFR, VEGFR, FGFR, IGF-1R, Src

Cat.No: T4318

Synonym: ACTB-1003,ACTB1003,ACTB 1003

Target: VEGFR, FGFR, Tie-2

Cat.No: T3726

Synonym: 厄达替尼,JNJ-42756493

Target: Apoptosis, FGFR

Cat.No: T6996

Synonym: SU5402

Target: VEGFR, FGFR, PDGFR

Cat.No: T1948

Target: VEGFR, FGFR

Infigratinib phosphate

Cat.No: T16364

Synonym: NVP-BGJ398 phosphate,BGJ-398 phosphate

Target: FGFR

Cat.No: T22306

Target: FGFR, Src

Cat.No: TQ0015

Target: c-Fms, FGFR, CSF-1R

Cat.No: T15185

Synonym: E-3810,德立替尼

Target: VEGFR, FGFR

Cat.No: T1975

Synonym: BGJ-398,NVP-BGJ398

Target: Apoptosis, FGFR

Cat.No: T6836

Target: FGFR

Cat.No: T3274

Target: FGFR, c-Met/HGFR, TAM Receptor

Cat.No: TQ0228

Synonym: ARQ-087

Target: FGFR

Tyrosine kinase-IN-1

Cat.No: T5466

Target: VEGFR, FGFR, FLT, PDGFR

Cat.No: T12401

Synonym: INCB054828

Target: FGFR

Cat.No: T6024

Synonym: FF284,CH5183284,Debio 1347

Target: FGFR

Cat.No: T8976

Target: EGFR, FGFR, PDGFR, Src

Cat.No: T1777

Synonym: BIBF 1120,Intedanib,尼达尼布

Target: VEGFR, FGFR, FLT, PDGFR, Src

Cat.No: T2358

Target: Apoptosis, VEGFR, FGFR, FLT, c-RET, PDGFR, Src, Aurora Kinase

Nintedanib esylate

Cat.No: T5001

Synonym: Intedanib,乙磺酸尼达尼布,BIBF 1120 (esylate),尼达尼布乙磺酸盐,Nintedanib Ethanesulfonate Salt,BIBF 1120

Target: VEGFR, FGFR, PDGFR

Cat.No: T3466

Target: EGFR, FGFR

Cat.No: T3492

Synonym: PD166866

Target: FGFR, Autophagy

Cat.No: T5473

Synonym: ASP-5878

Target: FGFR

Cat.No: T6338

Synonym: PHA 680632,PHA680632

Target: FGFR, PLK, Aurora Kinase

Cat.No: T61304

Target: FGFR

Cat.No: T2361

Synonym: LY 2874455,LY-2874455

Target: VEGFR, FGFR

Cat.No: T6289

Synonym: TKI258,多韦替尼,CHIR-258,度维替尼

Target: VEGFR, FGFR, FLT, PDGFR, c-Kit

Cat.No: T0520

Synonym: 仑伐替尼,E7080

Target: VEGFR, FGFR, c-RET, PDGFR, c-Kit

Lenvatinib mesylate

Cat.No: T8541

Synonym: 仑伐替尼甲酸盐,E7080 (mesylate),乐伐替尼

Target: VEGFR, FGFR, c-RET, PDGFR, c-Kit

Cat.No: TQ0317

Synonym: R-1530,R 1530

Target: VEGFR, FGFR, FLT, PDGFR

Cat.No: T4075

Synonym: KDR-IN-1,索凡替尼

Target: VEGFR, FGFR, HER

Cat.No: T6184

Synonym: SU6668,TSU-68,NSC 702827

Target: Apoptosis, VEGFR, FGFR, PDGFR

Ponatinib Hydrochloride

Cat.No: T2372L

Synonym: AP 24534,AP-24534 Hydrochloride,AP-24534,Ponatinib hydrochloride,AP24534 Hydrochloride,AP24534

Target: VEGFR, FGFR, PDGFR, Src

Cat.No: T36680

Target: Serine/threonin kinase, MAPK, LIM Kinase, TGF-beta/Smad, AAK1 (AP2 associated kinase 1)

Cat.No: T14363

Synonym: AZ 23,AZ23

Target: Trk receptor

Cat.No: T2341

Synonym: KW2449

Target: Apoptosis, FGFR, FLT, JAK, Bcr-Abl, Src, c-Kit, Aurora Kinase

Cat. No.	Product Name	Target	Signaling Pathways
T2215	Ferulic Acid Coniferic acid,Fumalic Acid,阿魏酸	FGFR; Endogenous Metabolite	Angiogenesis; Metabolism; Tyrosine Kinase/Adaptors
	Ferulic Acid (Coniferic acid) 是新型的成纤维细胞生长因子受体 1 (FGFR1)抑制剂, 在FGFR1和FGFR2的IC50分别为 3.78 和 12.5 μM。
T2S0007	Ferulic acid sodium 阿魏酸钠,阿魏酸钠；3-甲氧基-4-羟基肉桂酸钠,Sodium ferulic,Ferulic acid sodium salt,Sodium ferulate	FGFR; Reactive Oxygen Species; 5-HT Receptor; Endogenous Metabolite	Angiogenesis; GPCR/G Protein; Immunology/Inflammation; Metabolism; Neuroscience; NF-κB; Tyrosine Kinase/Adaptors
	Ferulic acid sodium (Sodium ferulic) 是新型的成纤维细胞生长因子受体 1 (FGFR1) 抑制剂。它对于FGFR1和FGFR2的IC50分别为 3.78 and 12.5 μM。
T40832	Ferulic acid acyl-β-D-glucoside Ferulic acid glucoside,Ferulic acid acyl-β-D-glucoside
	Ferulic acid acyl-β-D-glucoside, a metabolite of Ferulic Acid, is a novel inhibitor of fibroblast growth factor receptor 1 (FGFR1). It exhibits IC50 values of 3.78 µM and 12.5 µM for FGFR1 and FGFR2, respectively.

天然产物

Cat.No: T2215

Synonym: Coniferic acid,Fumalic Acid,阿魏酸

Target: FGFR, Endogenous Metabolite

Ferulic acid sodium

Cat.No: T2S0007

Synonym: 阿魏酸钠,阿魏酸钠；3-甲氧基-4-羟基肉桂酸钠,Sodium ferulic,Ferulic acid sodium salt,Sodium ferulate

Target: FGFR, Reactive Oxygen Species, 5-HT Receptor, Endogenous Metabolite

Ferulic acid acyl-β-D-glucoside

Cat.No: T40832

Synonym: Ferulic acid glucoside,Ferulic acid acyl-β-D-glucoside

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-06036	FGFR1 Protein, Human, Recombinant (alpha (IIIb), His) FGFR-1,FLG,CD331,HH2,FLT2,KAL2,FG...	Human	HEK293 Cells
	FGFR1 Protein, Human, Recombinant (alpha (IIIb), His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 40.5 kDa and the accession number is P11362-7.
TMPY-01011	FGFR1 Protein, Human, Recombinant (His) KAL2,FLT2,FGFBR,HRTFDS,OGD,FLG,HBGFR,bFGF-R-1,CD33<...	Human	HEK293 Cells
	FGFR1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 31 kDa and the accession number is H9FRD4.
TMPK-00393	FGFR1 alpha (IIIc) Protein, Human, Recombinant (His & Avi) FGFR1 α,FGFR1 alpha,FGF ...	Human	HEK293 Cells
	FGFR1 alpha (IIIc) Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 42 kDa and the accession number is P11362-7.
TMPY-06034	FGFR1 Protein, Human, Recombinant (beta (IIIb), His) FLG,CD331,N-SAM,HBGFR,HRTFDS,BFGFR,OGD,KAL...	Human	HEK293 Cells
	FGFR1 Protein, Human, Recombinant (beta (IIIb), His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 30.8 kDa and the accession number is H9FRD4.
TMPK-00395	FGFR1 alpha (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated FGF R1a,FGFR1 α,FGFR...	Human	HEK293 Cells
	FGFR1 alpha (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 42 kDa and the accession number is P11362-7.
TMPK-00392	FGFR1 beta (IIIc) Protein, Human, Recombinant (His & Avi) CD331,FGFR-1,FLT-2,BFGFR...	Human	HEK293 Cells
	Fibroblast growth factor receptor 1 (FGFR1) transmits signals through the plasma membrane regulating essential cellular processes like division, motility, metabolism, and death. Overexpression of FGFR1 is observed in numerous tumors and thus constitutes an attractive molecular target for selective cancer treatment. FGFR1 beta (IIIc) Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 25.23 kDa and the accession numb...
TMPK-00394	FGFR1 beta (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated FGFR1 β (IIIc),N-sam,FLT-2,BFGFR,...	Human	HEK293 Cells
	Fibroblast growth factor receptor 1 (FGFR1) transmits signals through the plasma membrane regulating essential cellular processes like division, motility, metabolism, and death. Overexpression of FGFR1 is observed in numerous tumors and thus constitutes an attractive molecular target for selective cancer treatment. FGFR1 beta (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 25.23 kDa and the ...
TMPY-03455	FGFR1OP Protein, Human, Recombinant (His & GST) FGFR1 oncogene partner,FOP	Human	Baculovirus Insect Cells
	FOP( fibroblast growth factor receptor 1 oncogene partner) is a largely hydrophilic protein postulated to be a leucine-rich protein family member. FOP contains 1 LisH domain. A t(6;8)(q27;p11) chromosomal translocation, fusing FOP gene and the fibroblast growth factor receptor 1 (FGFR1) gene, has been found in cases of myeloproliferative disorder. The resulting chimeric protein contains the N-terminal leucine-rich region of this encoded protein fused to the catalytic domain of FGFR1. FOP g...
TMPY-06035	FGFR1 Protein, Human, Recombinant (alpha (IIIb), hFc) KAL2,OGD,N-SAM,CEK,FLT2,HH2,FLG,CD331,BFGFR	Human	HEK293 Cells
	FGFR1 Protein, Human, Recombinant (alpha (IIIb), hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 65.7 kDa and the accession number is P11362-7.
TMPY-05777	FGFR1 Protein, Human, Recombinant (hFc) N-SAM,OGD,HH2,HBGFR,FLT2,CEK,FLG,FGFR-1,FG...	Human	HEK293 Cells
	FGFR1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 56.15 kDa and the accession number is NP_001341297.1.
TMPY-06033	FGFR1 Protein, Human, Recombinant (beta (IIIb), hFc) HBGFR,BFGFR,bFGF-R-1,FLG,FGFR-	Human	HEK293 Cells
	FGFR1 Protein, Human, Recombinant (beta (IIIb), hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 56 kDa and the accession number is H9FRD4.
TMPY-05761	FGFR1 Protein, Human, Recombinant (His), Biotinylated FLT-2,KAL2,FGFBR,HRTFDS,BFGFR,fibroblast growth fac...	Human	HEK293 Cells
	FGFR1 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 31 kDa and the accession number is H9FRD4.
TMPY-04371	FGFR1 Protein, Human, Recombinant (His & GST) HRTFDS,CEK,OGD,FLG,FLT2,FGFBR,bFGF-R-1,N-SAM,fibrob...	Human	Baculovirus Insect Cells
	FGFR1 Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 75 kDa and the accession number is H9FRD4.
TMPY-03350	FGFR1 Protein, Rhesus, Recombinant (hFc) fibroblast growth factor receptor 1	Rhesus	HEK293 Cells
	FGFR1 Protein, Rhesus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 56.2 kDa and the accession number is H9FRD4.
TMPY-01781	FGFR1 Protein, Mouse, Recombinant (His) Flt-2,FLG,fibroblast growth factor receptor 1,bFGF-...	Mouse	HEK293 Cells
	FGFR1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 40.9 kDa and the accession number is P16092-1.
TMPY-01782	FGFR1 Protein, Mouse, Recombinant (hFc) Hspy,fibroblast growth factor receptor 1,bFGF-R-	Mouse	HEK293 Cells
	FGFR1 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 66.5 kDa and the accession number is P16092-1.
TMPH-01337	FGFR1 Protein, Human, Recombinant (Yeast, His)	Human	P. pastoris (Yeast)
	FGFR1 Protein, Human, Recombinant (Yeast, His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 41.4 kDa and the accession number is P11362.
TMPY-03926	FGFR1 Protein, Rhesus, Recombinant (His) fibroblast growth factor receptor 1	Rhesus	HEK293 Cells
	FGFR1 Protein, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 30.6 kDa and the accession number is H9FRD4.
TMPH-01336	FGFR1 Protein, Human, Recombinant (E. coli, His)	Human	E. coli
	FGFR1 Protein, Human, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 43.4 kDa and the accession number is P11362.
TMPY-02907	FGF-19 Protein, Human, Recombinant fibroblast growth factor 19,FGF19	Human	E. coli
	FGF19, also known as FGF-19, is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF19 interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by KL, KLB and heparan sulfate glycosaminoglyca...
TMPY-02032	FLRT1 Protein, Human, Recombinant (His) SPG68,fibronectin leucine rich transmembrane protein 1	Human	HEK293 Cells
	The three fibronectin leucine-rich repeat transmembrane (FLRT) proteins contain 10 leucine-rich repeats (LRR), a type III fibronectin (FN) domain, followed by the transmembrane region, and a short cytoplasmic tail. FLRT1 is expressed in kidney and brain, which is a target for tyrosine phosphorylation mediated by FGFR1 and implicates a non-receptor Src family kinase (SFK). All FLRTs can interact with FGFR1 and FLRTs can be induced by the activation of FGF signalling by FGF-2. The phosphorylation ...
TMPH-00368	FGF-2 Protein, Chicken, Recombinant (His)	Chicken	P. pastoris (Yeast)
	Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. FGF-2 Protein, Chicken, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 18.3 kDa and the accession number is P48800.
TMPH-03203	FGFb Protein, Rabbit, Recombinant (His & SUMO)	Rabbit	E. coli
	Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Mediates phosphorylation of ERK1/2 and thereby promotes retinal lens fiber differentiation. FGFb Protein, Rabbit, Recombinant (His & SUMO) is expressed in E. coli exp...
TMPY-04025	CEP57 Protein, Human, Recombinant (GST) MVA2,PIG8,TSP57,centrosomal protein 57kDa	Human	E. coli
	CEP57 is a centrosomal protein and is involved in nucleating and stabilizing microtubules. CEP57 was initially identified as a regulator of centriole overduplication in an RNA interference screen. There is a link between altered microenvironmental signaling cues such as FGF-2 overexpression and mitotic instability and provide a rationale for the therapeutic targeting of the FGF-2/FGFR1/CEP57 axis in prostate cancer. CEP57 is involved in intracellular transport processes, and its overexpression c...
TMPH-00369	FGF-2 Protein, Chicken, Recombinant (His & Myc)	Chicken	E. coli
	Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. FGF-2 Protein, Chicken, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 23.8 kDa and the accession number is P48800.
TMPJ-01224	FGFRL1 Protein, Human, Recombinant (His) FGFR5,FGFR-5,FGFRL1,...	Human	HEK293 Cells
	Fibroblast Growth Factor Receptor-Like 1 (FGFRL1) is a single-pass type I membrane protein that belongs to the FGF receptor family. The mature human FGFRL1 consists of a 354 amino acid extracellular domain (ECD) with 3 Ig-like C2-type domains, a 21 amino acid transmembrane segment, and a 134 amino acid cytoplasmic domain. FGFR1 expressed in various tissues, preferentially in cartilaginous tissues and pancreas. It highly expressed in the liver, kidney, heart, brain and skeletal muscle, weakly exp...
TMPJ-00376	IL-17RD Protein, Human, Recombinant (hFc) IL17Rhom,IL17RD,IL-17RD,IL-1<...	Human	HEK293 Cells
	Interleukin-17 receptor D (IL-17 RD), also known as SEF (similar expression to FGFs), is a type I transmembrane protein that is found in both the cytoplasm and plasma membrane. IL-17RD functions as a feedback inhibitor of fibroblast growth factor mediated Ras-MAPK signaling and ERK activation. It may inhibit FGF-induced FGFR1 tyrosine phosphorylation, regulate the nuclear ERK signaling pathway by spatially blocking nuclear translocation of activated ERK By similarity, and mediate JNK activation ...
TMPY-02240	STAT1 Protein, Human, Recombinant (His & GST) IMD31A,IMD31B,IMD31C,STAT91	Human	Baculovirus Insect Cells
	STAT1 is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor-associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. STAT1 can be activated by various ligands, including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. It is a signal transducer and transcription activator that mediates cellular responses to interferons (IFNs),...

重组蛋白

FGFR1 Protein, Human, Recombinant (alpha (IIIb), His)

Cat.No: TMPY-06036

Species: Human

Expression System: HEK293 Cells

FGFR1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01011

Species: Human

Expression System: HEK293 Cells

FGFR1 alpha (IIIc) Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00393

Species: Human

Expression System: HEK293 Cells

FGFR1 Protein, Human, Recombinant (beta (IIIb), His)

Cat.No: TMPY-06034

Species: Human

Expression System: HEK293 Cells

FGFR1 alpha (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00395

Species: Human

Expression System: HEK293 Cells

FGFR1 beta (IIIc) Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00392

Species: Human

Expression System: HEK293 Cells

FGFR1 beta (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00394

Species: Human

Expression System: HEK293 Cells

FGFR1OP Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-03455

Species: Human

Expression System: Baculovirus Insect Cells

FGFR1 Protein, Human, Recombinant (alpha (IIIb), hFc)

Cat.No: TMPY-06035

Species: Human

Expression System: HEK293 Cells

FGFR1 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-05777

Species: Human

Expression System: HEK293 Cells

FGFR1 Protein, Human, Recombinant (beta (IIIb), hFc)

Cat.No: TMPY-06033

Species: Human

Expression System: HEK293 Cells

FGFR1 Protein, Human, Recombinant (His), Biotinylated

Cat.No: TMPY-05761

Species: Human

Expression System: HEK293 Cells

FGFR1 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-04371

Species: Human

Expression System: Baculovirus Insect Cells

FGFR1 Protein, Rhesus, Recombinant (hFc)

Cat.No: TMPY-03350

Species: Rhesus

Expression System: HEK293 Cells

FGFR1 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-01781

Species: Mouse

Expression System: HEK293 Cells

FGFR1 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-01782

Species: Mouse

Expression System: HEK293 Cells

FGFR1 Protein, Human, Recombinant (Yeast, His)

Cat.No: TMPH-01337

Species: Human

Expression System: P. pastoris (Yeast)

FGFR1 Protein, Rhesus, Recombinant (His)

Cat.No: TMPY-03926

Species: Rhesus

Expression System: HEK293 Cells

FGFR1 Protein, Human, Recombinant (E. coli, His)

Cat.No: TMPH-01336

Species: Human

Expression System: E. coli

FGF-19 Protein, Human, Recombinant

Cat.No: TMPY-02907

Species: Human

Expression System: E. coli

FLRT1 Protein, Human, Recombinant (His)

Cat.No: TMPY-02032

Species: Human

Expression System: HEK293 Cells

FGF-2 Protein, Chicken, Recombinant (His)

Cat.No: TMPH-00368

Species: Chicken

Expression System: P. pastoris (Yeast)

FGFb Protein, Rabbit, Recombinant (His & SUMO)

Cat.No: TMPH-03203

Species: Rabbit

Expression System: E. coli

CEP57 Protein, Human, Recombinant (GST)

Cat.No: TMPY-04025

Species: Human

Expression System: E. coli

FGF-2 Protein, Chicken, Recombinant (His & Myc)

Cat.No: TMPH-00369

Species: Chicken

Expression System: E. coli

FGFRL1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01224

Species: Human

Expression System: HEK293 Cells

IL-17RD Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00376

Species: Human

Expression System: HEK293 Cells

STAT1 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-02240

Species: Human

Expression System: Baculovirus Insect Cells

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