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63

抑制剂 & 化合物

51

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T29051	UK-122 TFA salt UK122,uPA Inhibitor II,UK122 TFA salt,UK 122,UK-122,K122 trifloroacetic acid
	UK-122 is a potent and selective uPA inhibitor (Ki = 20 nM). The IC(50) of UK122 in a cell-free indirect uPA assay is 0.2 micromol/L. UK122 showed little cytotoxicity against CFPAC-1 cells (IC(50) > 100 micromol/L) but significantly inhibited the migratio
T13408	ZK824190	Others; Serine Protease	Others; Proteases/Proteasome
	ZK824190 是具有口服活性尿激酶型纤溶酶原激活剂 (uPA) 选择性抑制剂，对 uPA，tPA 和 Plasmin 的IC50分别为 237，1600 和 1850 nM。ZK824190在多发性硬化症中有研究价值。
T8362	Benzamidine hydrochloride Benzamidine HCl,苄脒盐酸盐	Serine/threonin kinase; Serine Protease	Cell Cycle/Checkpoint; Metabolism; Proteases/Proteasome
	Benzamidine hydrochloride (Benzamidine HCl) 是可逆的胰蛋白酶样丝氨酸蛋白酶 (trypsin-like serine proteases) 竞争性抑制剂，对 uPA、类胰蛋白酶、胰蛋白酶和 Xa 因子作用的Ki 分别为 97 µM、20 µM、21 µM 和 110 µM。
T13257	Upamostat	PAI-1; Serine/threonin kinase; Serine Protease	Cell Cycle/Checkpoint; Metabolism; Proteases/Proteasome
	Upamostat 是一种丝氨酸蛋白酶抑制剂，也是一种具有口服活性的 WX-UK1 前药，是一种尿激酶型纤溶酶原激活剂 (uPA) 抑制剂。
T11122	DUPA(OtBu)-OH (S)-5-叔丁氧基-4-(3-((S)-1,5-二-叔丁氧基-1,5-二氧代-2-戊基)脲啶)-5-氧代戊酸	Others	Others
	DUPA(OtBu)-OH 是DUPA 前体。其中 DUPA 是传递 Docetaxel (DTX) 的靶向基序，可用于表达前列腺特异性膜抗原的前列腺肿瘤的研究。
T77412	Lupartumab BAY 1112623	Others	Others
	Lupartumab (BAY 1112623) 是一种抗 LYPD3 (C4.4A) 单克隆抗体，可用于合成抗体-活性分子偶联物，可用于研究与 LYPD3 相关的肿瘤疾病。
T6242	Rupatadine Fumarate 富马酸卢帕他定,Rinialer,Rupafin,Alergoliber	PAFR; Autophagy; Histamine Receptor	Autophagy; GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Rupatadine Fumarate (Rinialer) 是一种可口服的长效PAF/H1受体的双抑制剂，Ki 值分别为 0.55 μM 和 0.1 μM。它可研究过敏性鼻炎和荨麻疹。
T4269	Buparvaquone 布帕伐醌,Butalex,BW 720C	Antibiotic; Parasite	Microbiology/Virology
	Buparvaquone (BW 720C) 是与parvaquone 和atovaquone 有关的一种羟基萘醌类抗原虫药。
T19301	DUPA N,N''-Carbonylbis[L-glutamic acid],(2S,2'S)-2,2'-Carbonylbis(Azanediyl)Dipentanedioic Acid	Others; Ligands for Target Protein for PROTAC	Others; PROTAC
	DUPA (N,N''-Carbonylbis[L-glutamic acid]) 是谷氨酸脲，在药物偶联中作为靶向部分，可选择靶向性地将细胞毒性药物递送到前列腺癌细胞。
TP2338L	Cenupatide acetate Cenupatide acetate(1006388-38-0 Free base)	Others	Others
	Cenupatide acetate 是一种尿激酶纤溶酶原激活物受体 (uPAR) 抑制剂，用于治疗与细胞迁移改变相关的疾病，例如癌症。
T61932	Nesuparib JPI-547/OCN-201	PARP; Wnt/beta-catenin	Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; Stem Cells
	Nesuparib (JPI-547/OCN-201) 是一种有效的PARP抑制剂，对PARP 和TNKS1具有抑制作用。Nesuparib 具有抗肿瘤活性，可用于治疗肿瘤、内分泌与代谢疾病、泌尿生殖系统疾病，可用于研究神经性疼痛、神经退行性疾病和心血管疾病。
T1827	Buparlisib BKM120,布帕尼西,NVP-BKM120	Apoptosis; PI3K	Apoptosis; PI3K/Akt/mTOR signaling
	Buparlisib (BKM120) 是一种具有口服生物利用度的泛 I 类 PI3K 特异性口服抑制剂，对p110α/p110β/p110δ/p110γ的IC50分别为 52 nM/166 nM/116 nM/262 nM。
T29067L	Upacicalcet HCl Upacicalcet HCl(1333218-50-0 Free base)	CaSR	GPCR/G Protein
	Upacicalcet HCl 是一种静脉内拟钙剂，通过直接作用于甲状旁腺细胞膜钙敏感受体来抑制过量的甲状旁腺激素 (PTH) 分泌，从而降低血液中的 PTH 水平。Upacicalcet HCl 可用于治疗血液是一种新型继发性甲状旁腺功能亢进化合物，靶向钙敏感受体的氨基酸结合位点。
T76735	Mupadolimab CPI-006	CD73	Immunology/Inflammation
	Mupadolimab (CPI-006) 是一种人源化 FcγR 结合缺陷型 IgG1 抗 CD73抗体，具有潜在的抗癌活性，可激活 CD73POS B 细胞。
T29067	Upacicalcet PLS-240,SK-1403,AJT-240	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Upacicalcet (AJT-240) 是一种静脉内拟钙剂，是一种可用于人血液透析的 SHPT，通过直接作用于甲状旁腺细胞膜钙敏感受体来抑制过量的甲状旁腺激素 (PTH) 分泌，从而降低血液中的 PTH 水平。 3 Upacicalcet 是钙敏感受体的正变构调节剂，可预防大鼠腺嘌呤诱导的继发性甲状旁腺功能亢进模型中的血管钙化和骨骼疾病。
T77566	(3aR,9aR)-Fluparoxan	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	(3aR,9aR)-Fluparoxan 是一种高度选择性和有效的肾上腺素能受体α2B 拮抗剂，可用于预防、改善或治疗神经发育障碍和神经退行性疾病。
T77565	Fluparoxan hydrochloride	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Fluparoxan hydrochloride 是一种高度选择性和有效的α2-肾上腺素受体拮抗剂，可用于预防、改善或治疗神经发育障碍和神经退行性疾病。
T7503	Upadacitinib 乌帕替尼,ABT-494	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	Upadacitinib (ABT-494) 是高效选择性的，具有口服活性的 JAK1抑制剂，IC50为43 nM，可用于多种自身免疫性疾病的研究。它对 JAK1 的选择性约为 JAK2 的 74 倍。
TP2338	Cenupatide UPARANT,Cenupatide trifluoroacetic acid salt,Ac-Arg-Aib-Arg-α(Me)Phe-NH2)
	Cenupatide is a urokinase plasminogen activator receptor (uPAR) inhibitor. Cenupatide inhibits uPAR binding to the formyl peptide receptors (FPRs) can improve kidney lesions in a rat model of STZ-induced diabetes. Cenupatide reverted STZ-induced up-regula
T27340	Fluparoxan HCl GR50360,GR 50360,Fluparoxan hydrochloride,GR-50360A,GR-50360
	Fluparoxan is a potent α2-adrenergic receptor antagonist (pKB = 7.9) with excellent α2/α1 selectivity (2630 fold).
T124968	Eupalitin 3-galactoside
	Eupalitin 3-galactoside 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T124968。
T125919	Eupalinolide H
	Eupalinolide H 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T125919。
T32968	Lupanol 3-beta-diglucoside
	Lupanol 3-beta-diglucoside is a bioactive chemcial.
T61232	(Rac)-Upacicalcet
	(Rac)-Upacicalcet is a racemate of Upacicalcet, which serves as an intravenous calcimimetic agent. Upacicalcet acts by directly targeting calcium-sensing receptors on parathyroid cell membranes, effectively suppressing the release of excessive parathyroid hormone (PTH) and reducing blood PTH levels. This compound holds the potential for researching secondary hyperparathyroidism (SHPT) [1].
T29291L	17-Oxolupanine hydrochloride
	17-Oxolupanine hydrochloride is a drug / Therapeutic Agent.
T125102	Eupatoletin
	Eupatoletin 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T125102。
T70785	Mefuparib Free Base
	Mefuparib Free Base is a potent, highly selective, competitive PARP1/2 inhibitor with IC50 of 3.2/1.9 nM, respectively. Mefuparib (CVL218), has been shown to have promising antiviral activity against the virus that causes COVID-19.
T131460	3,20,29-Lupanetriol
	3,20,29-Lupanetriol 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T131460。
T37014	Inupadenant
	Inupadenant is an orally active, highly selective A2A receptor antagonist. Inupadenant is not brain-penetrant. Inupadenant has potent anti-tumor activity[1]. [1]. Laurence Buisseret, et al. Phase 1 trial of the adenosine A2Areceptor antagonist inupadenant (EOS-850): Update on tolerability, and antitumor activity potentially associated with the expression of the A2A receptor within the tumor. Journal of Clinical Oncology. Volume 39, Issue 15_suppl.
T32964	Lupanine perchlorate
	Lupanine perchlorate is a bioactive chemical.
T36618	Rupatadine
	Rupatadine (UR-12592) is a potent dual PAF/H1 antagonist with Ki of 0.55/0.1 uM(rabbit platelet membranes/guinea pig cerebellum membranes).IC50 value:Target: PAF/H1 antagonistin vitro: Rupatadine competitively inhibited histamine-induced guinea pig ileum contraction (pA2 = 9.29 +/- 0.06) without affecting contraction induced by ACh, serotonin or leukotriene D4 (LTD4). It also competitively inhibited PAF-induced platelet aggregation in washed rabbit platelets (WRP) (pA2 = 6.68 +/- 0.08) and in hu...
T11992	Mefuparib hydrochloride MPH	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Mefuparib hydrochloride induces apoptosis and possesses prominent anticancer activity in vitro and in vivo. Mefuparib hydrochloride (MPH) is an orally active, substrate-competitive and selective PARP1/2 inhibitor with IC50s of 3.2 nM and 1.9 nM, respectively.
T16365	Buparlisib Hydrochloride NVP-BKM120 Hydrochloride,BKM120 Hydrochloride	Others	Others
	Buparlisib Hydrochloride is an inhibitor of pan-class I PI3K (IC50: 52 nM/166 nM/116 nM/262 nM for p110α/p110β/p110δ/p110γ, respectively).
T80918	Tuparstobart Incagn-02385
	Tuparstobart (Incagn-02385)为针对LAG-3的IgG1κ抗体。LAG-3，作为一种免疫检查点受体蛋白，其主要存在于活化T细胞、NK细胞、B细胞及浆细胞树突细胞上。
T68074	fluparoxan
	Fluparoxan 是一种高选择性和有效的α 2-肾上腺素受体拮抗剂。
T32966	Lupanine, 17-hydroxy-
	Lupanine, 17-hydroxy- is a bioactive chemical.
T124623	Eupassopilin
	Eupassopilin 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T124623，CAS号为 57718-81-7。
T39444	Upacicalcet sodium
	Upacicalcet (sodium) is an intravenous calcimimetic agent that acts directly on parathyroid cell membrane calcium-sensing receptors to suppress excessive parathyroid hormone (PTH) secretion, thereby lowering blood PTH levels. It is indicated for the research of secondary hyperparathyroidism (SHPT).
T7503L	Upadacitinib tartrate ABT 494,ABT-494,ABT494
	Upadacitinib is a potent and selective JAK inhibitor. Upadacitinib is approximately 74 fold selective for Jak1 over Jak2 in cellular assays dependent on specific, relevant cytokines. Upadacitinib demonstrates efficacy in rat arthritis models.
T32965	Lupanine dihydrochloride, (+/-)-
	Lupanine dihydrochloride, (+/-)- is a bioactive chemical.
T69648	Inupadenant HCl
	Inupadenant, also known as EOS-850, is a highly selective small molecule antagonist of the adenosine A2a receptor, in the adenosine triphosphate adenosine pathway, a key driver of immunosuppression in the tumor microenvironment across a broad range of tumors.
T124791	alpha-Isolupanine
	alpha-Isolupanine 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T124791。
T80895	Upanovimab SCTA01
	Upanovimab (SCTA01) 是一种具有选择性的单克隆抗体。
T32967	Lupanine, 17-hydroxy-, monohydrochloride
	Lupanine, 17-hydroxy-, monohydrochloride is a drug / Therapeutic Agent.
T29291	17-Oxolupanine
	17-Oxolupanine is a bioactive chemical.
T3442	UK-371804 UK371804	PAI-1; Serine Protease	Metabolism; Proteases/Proteasome
	UK-371804 是一种尿嘧啶型纤溶酶原激活物的抑制剂，Ki=10 nM。
T60248	4-Aminobenzamidine dihydrochloride p-Aminobenzamidine dihydrochloride	Serine Protease	Proteases/Proteasome
	4-Aminobenzamidine dihydrochloride (p-Aminobenzamidine dihydrochloride) 是一种强胰蛋白酶 (trypsin)抑制剂，也是一种相对较弱的尿激酶型纤溶酶原激活剂 (uPA) 抑制剂 (Ki=82 μM)。4-Aminobenzamidine 可抑制 SCID 小鼠体内前列腺肿瘤的生长。
T26629	Angstrom6 A-6,A 6 peptide,A6,A 6,A6 peptide,A-6 peptide	PAI-1	Metabolism
	Angstrom6 (A-6 peptide) 是一种从单链尿激酶纤溶酶原激活剂(scuPA)中提取的 8 肽，它能干扰 uPA/uPAR 级联反应并抑制下游效应。Angstrom6 具有抗肿瘤活性，能通过与 CD44 结合并调节 CD44 介导的细胞信号传导，抑制肿瘤细胞的迁移、侵袭和转移。
T13409	ZK824859	Others	Others
	ZK824859 is an oral available and selective inhibitor of urokinase plasminogen activator (uPA)(IC50s of 79 nM, 1580 nM and 1330 nM for human uPA, tPA, and plasmin, respectively).
T13409L	ZK824859 hydrochloride (2271122-53-1 free base) ZK824859 hydrochloride	Others	Others
	ZK824859 hydrochloride is an oral available and selective inhibitor of urokinase plasminogen activator (uPA)(IC50s of 79 nM, 1580 nM and 1330 nM for human uPA, tPA, and plasmin, respectively).

化合物

UK-122 TFA salt

Cat.No: T29051

Synonym: UK122,uPA Inhibitor II,UK122 TFA salt,UK 122,UK-122,K122 trifloroacetic acid

Cat.No: T13408

Target: Others, Serine Protease

Benzamidine hydrochloride

Cat.No: T8362

Synonym: Benzamidine HCl,苄脒盐酸盐

Target: Serine/threonin kinase, Serine Protease

Cat.No: T13257

Target: PAI-1, Serine/threonin kinase, Serine Protease

Cat.No: T11122

Synonym: (S)-5-叔丁氧基-4-(3-((S)-1,5-二-叔丁氧基-1,5-二氧代-2-戊基)脲啶)-5-氧代戊酸

Target: Others

Cat.No: T77412

Synonym: BAY 1112623

Target: Others

Rupatadine Fumarate

Cat.No: T6242

Synonym: 富马酸卢帕他定,Rinialer,Rupafin,Alergoliber

Target: PAFR, Autophagy, Histamine Receptor

Cat.No: T4269

Synonym: 布帕伐醌,Butalex,BW 720C

Target: Antibiotic, Parasite

Cat.No: T19301

Synonym: N,N''-Carbonylbis[L-glutamic acid],(2S,2'S)-2,2'-Carbonylbis(Azanediyl)Dipentanedioic Acid

Target: Others, Ligands for Target Protein for PROTAC

Cenupatide acetate

Cat.No: TP2338L

Synonym: Cenupatide acetate(1006388-38-0 Free base)

Target: Others

Cat.No: T61932

Synonym: JPI-547/OCN-201

Target: PARP, Wnt/beta-catenin

Cat.No: T1827

Synonym: BKM120,布帕尼西,NVP-BKM120

Target: Apoptosis, PI3K

Upacicalcet HCl

Cat.No: T29067L

Synonym: Upacicalcet HCl(1333218-50-0 Free base)

Target: CaSR

Cat.No: T76735

Synonym: CPI-006

Target: CD73

Cat.No: T29067

Synonym: PLS-240,SK-1403,AJT-240

Target: Calcium Channel

(3aR,9aR)-Fluparoxan

Cat.No: T77566

Target: Adrenergic Receptor

Fluparoxan hydrochloride

Cat.No: T77565

Target: Adrenergic Receptor

Cat.No: T7503

Synonym: 乌帕替尼,ABT-494

Target: JAK

Cat.No: TP2338

Synonym: UPARANT,Cenupatide trifluoroacetic acid salt,Ac-Arg-Aib-Arg-α(Me)Phe-NH2)

Cat.No: T27340

Synonym: GR50360,GR 50360,Fluparoxan hydrochloride,GR-50360A,GR-50360

Eupalitin 3-galactoside

Cat.No: T124968

Cat.No: T125919

Lupanol 3-beta-diglucoside

Cat.No: T32968

(Rac)-Upacicalcet

Cat.No: T61232

17-Oxolupanine hydrochloride

Cat.No: T29291L

Cat.No: T125102

Mefuparib Free Base

Cat.No: T70785

3,20,29-Lupanetriol

Cat.No: T131460

Cat.No: T37014

Lupanine perchlorate

Cat.No: T32964

Cat.No: T36618

Mefuparib hydrochloride

Cat.No: T11992

Synonym: MPH

Target: PARP

Buparlisib Hydrochloride

Cat.No: T16365

Synonym: NVP-BKM120 Hydrochloride,BKM120 Hydrochloride

Target: Others

Cat.No: T80918

Synonym: Incagn-02385

Cat.No: T68074

Lupanine, 17-hydroxy-

Cat.No: T32966

Cat.No: T124623

Upacicalcet sodium

Cat.No: T39444

Upadacitinib tartrate

Cat.No: T7503L

Synonym: ABT 494,ABT-494,ABT494

Lupanine dihydrochloride, (+/-)-

Cat.No: T32965

Inupadenant HCl

Cat.No: T69648

alpha-Isolupanine

Cat.No: T124791

Cat.No: T80895

Synonym: SCTA01

Lupanine, 17-hydroxy-, monohydrochloride

Cat.No: T32967

Cat.No: T29291

Cat.No: T3442

Synonym: UK371804

Target: PAI-1, Serine Protease

4-Aminobenzamidine dihydrochloride

Cat.No: T60248

Synonym: p-Aminobenzamidine dihydrochloride

Target: Serine Protease

Cat.No: T26629

Synonym: A-6,A 6 peptide,A6,A 6,A6 peptide,A-6 peptide

Target: PAI-1

Cat.No: T13409

Target: Others

ZK824859 hydrochloride (2271122-53-1 free base)

Cat.No: T13409L

Synonym: ZK824859 hydrochloride

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T5826	Eupalinolide A	HSP	Cytoskeletal Signaling; Metabolism
	Eupalinolide A 是分离于林泽兰中的一种天然产物，通过抑制 HSF1 与 HSP90 的相互作用，激活 HSF1，诱导 HSP70 的表达。它对 A-549、BGC-823、SMMC-7721 和 HL-60 肿瘤细胞系具有强大的细胞毒性。
T6S2238	Eupalinolide B	Others	Others
	Eupalinolide B 是一种胚芽倍半萜，分离自Eupatorium lindleyanum 中。它对BGC-823、A-549 和 HL-60 等肿瘤细胞具有细胞毒性。
TN3469	Aucuparin 2,6-dimethoxy-4-phenylphenol	NADPH-oxidase	Immunology/Inflammation
	Aucuparin (2,6-dimethoxy-4-phenylphenol) 是一种植物抗菌素，具有抗炎活性。在博来霉素 (BLM) 诱导的肺纤维化小鼠模型中，Aucuparin 抑制肺纤维化。在经ABTS 和FRAP 测定显示出明显的清除活性。 Aucuparin 对fmlp 诱导的人中性粒细胞产生超氧化物具有明显的抑制作用，其IC50为17.0μM。
TN6762	(+)-Cuparene	Others	Others
	(+)-Cuparene 是一种生物活性化学品。
T3362	Eupatilin NSC 122413,异泽兰黄素	PPAR; Autophagy	Autophagy; DNA Damage/DNA Repair; Metabolism
	Eupatilin (NSC-122413) 是一种从青蒿中提取的黄酮，是一种 PPARα 激动剂，具有药理活性。
T7032	Eupatorin	Others; P450	Metabolism; Others
	Eupatorin 是天然存在的黄酮，可捕获 G2-M 细胞周期，激活多个 caspase、细胞色素 C 的释放、多聚 (ADP-核糖) 聚合酶的裂解，促使凋亡细胞死亡。
TN1630	Eupalinilide D	Others	Others
	Eupalinilide D is a natural product from Impatiens balsamina L.
TN3503	Beta-Furoyleupatolide	Others	Others
	Beta-Furoyleupatolide 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN3503，CAS号为 114437-24-0。
TN4035	Eupalinolide I	STAT	JAK/STAT signaling; Stem Cells
	Eupalinolide I is a natural product from Eupatorium lindleyanum.
TN5160	trans-2,3-Dihydro-3-ethoxyeuparin	Others	Others
	trans-2,3-Dihydro-3-ethoxyeuparin 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN5160，CAS号为 1015698-14-2。
TN5964	Adiantulupanone
	Adiantulupanone 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN5964，CAS号为 51511-05-8。
TN4039	Eupatorin-5-methylether	Others	Others
	Eupatorin-5-methylether 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN4039，CAS号为 21764-09-0。
TN2843	2alpha-Hydroxyeupatolide 8-O-angelate	Others	Others
	2alpha-Hydroxyeupatolide 8-O-angelate is a natural product from Eupatorium chinense var. tozanense.
TN5161	trans-2,3-Dihydro-3-hydroxyeuparin	Others	Others
	trans-2,3-Dihydro-3-hydroxyeuparin 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN5161，CAS号为 64185-57-5。
TN1889	Lupalbigenin	ERK; Akt; Topoisomerase	Cytoskeletal Signaling; DNA Damage/DNA Repair; MAPK; PI3K/Akt/mTOR signaling
	Lupalbigenin sensitizes detachment-induced cell death in human lung cancer cell through down-regulation of pro-survival proteins.
TN1212	2-Hydroxyeupatolide	Others; TNF; NF-κB	Apoptosis; NF-κB; Others
	2-Hydroxyeupatolide has anti-inflammatory activity,it may suppress the inflammatory response through inhibiting the activation of NF-κB signaling pathways, and make a contribution to further understanding the pharmaceutical activity of Eupatorium plants.
TN5362	20-Dehydroeupatoriopicrin semiacetal
	20-Dehydroeupatoriopicrin semiacetal 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN5362，CAS号为 94234-24-9。
TN4308	Isolupalbigenin	Antifection	Microbiology/Virology
	Isolupalbigenin shows promising cytotoxic effects toward HL-60 cells (IC50 4.3 ± 0.7 to 18.0 ± 1.7 uM), it also shows in vitro inhibitory activity toward human glyoxalase I. Isolupalbigenin shows two different antibacterial activities against MRSA: direct growth inhibition and intensification of methicillin sensitivity, it could lead to the development of compounds for new approaches against MRSA infection.
TN4037	Eupatarone	Others	Others
	Eupatarone is a natural product from Eupatorium sternbergianum.
TN1631	Eupalinolide K [3AR-[3AR,4R(E),6E,9S,10E,11AR]]-4-羟基-2-甲基-2-丁烯酸 2,3,3A,4,5,8,9,11A-八氢-9-羟基-6,10-二甲基-3-亚甲基-2-氧代环癸五烯并[B]呋喃-4-基酯,野马追内酯 K,野马追内酯K	STAT	JAK/STAT signaling; Stem Cells
	Eupalinolide K 是来自野马追的一种倍半萜内酯，是 STAT3抑制剂，可作为迈克尔反应受体。
TN3780	Deacetyleupaserrin	Others	Others
	Deacetyleupaserrin is an antileukemic sesquiterpene lactone.
TN5531	Eupalitin 3,5,4'-Trihydroxy-6,7-dimethoxyflavone
	Eupalitin 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN5531，CAS号为 29536-41-2。
TN4034	Eupaglehnin C	Others	Others
	Eupaglehnin C shows cytotoxic (2.19 mg/ml) against HeLa-S3.
TN5358	Eupahualin C
	Eupahualin C shows significant activities against cell lines of human chronic myelogenous leukemia (K562) and human bone cancer (U2OS).
TN6563	Eupalinolide O
	Eupalinolide O 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN6563，CAS号为 2170228-67-6。
TN3899	Drupacine	Others	Others
	Drupacine and a crude alkaloid extract suppress nematode hatch, activity of mixed life stages, and population numbers on plant roots.
TN2888	3,4-Secolupa-4(23),20(29)-diene-3,28-dioic acid	Others	Others
	3,4-Secolupa-4(23),20(29)-diene-3,28-dioic acid exhibits potent inhibition of superoxide-anion generation with 86.9 ± 2.8% inhibition at 1 uM.
T82432	Eupatolin
	Eupatolin是从Rudbeckia hirta中提取的一种天然产物。
T83452	13β-Hydroxylupanine
	13β-Hydroxylupanine为Caulophyllum robustum Maxim中所含的天然化合物。
TN2596	12-Hydroxy-2,3-dihydroeuparin	Others	Others
	12-Hydroxy-2,3-dihydroeuparin是一种天然产物，属于菊科泽兰属，其产品编号为 TN2596，CAS号为 68776-42-1。12-Hydroxy-2,3-dihydroeuparin可用作对照参考。
TN2693	2,3-Dihydro-12,13-dihydroxyeuparin	Others	Others
	2,3-Dihydro-12,13-dihydroxyeuparin 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN2693，CAS号为 135531-75-8。
TMA0805	Lupanine	ATPase; Potassium Channel; Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Lupanine has a weak sedative effect on the central nervous system, interaction with specific drugs used for treatment of the CNS and for analgesic activity. Lupanine improves glucose homeostasis by influencing KATP-channels of pancreatic beta cells.
T83454	13-Hydroxylupanine hydrochloride Hydroxylupanine hydrochloride
	13-Hydroxylupanine是甜羽扇豆中一种典型的生物碱。它具有阻断神经节传递、降低心肌收缩力以及收缩子宫平滑肌的作用。
T81653	Noraucuparin
	Noraucuparin是从Sorbus pohuashanensis的叶子中分离得到的联苯型植物抗毒素，具有抗真菌作用。
T75644	Lupanine hydrochloride
	Lupanine (D-Lupanine) hydrochloride 是 Sparteine ((+)-Sparteine ) 的天然酮衍生物，具有神经节麻痹活性。Lupanine hydrochloride 对烟碱受体 (nicotinic receptor) (nAChR) 具有结合亲和力，Ki 值为 500 nM。
T78477	Drupanin
	Drupanin是从绿色蜂胶中分离出的一种化合物，能选择性抑制AKR1C3酶，并具有研究乳腺癌的潜力。
TN6574	13-Hydroxylupanine
	13-Hydroxylupanine is a natural product from Cytisus scoparius.
TN4041	Eupatoriopicrin	Others	Others
	Eupatoriopicrin shows anti-trypanosomal activity and cytotoxicity against Trypanosoma brucei rhodesiense. Eupatoriopicrin-induced DNA damage may play a role in the observed cytotoxicity, it shows a weak sensitizing capacity in guinea pigs.
TN2800	20-Hydroxy-3-oxo-28-lupanoic acid	Others	Others
	20-Hydroxy-3-oxo-28-lupanoic acid 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN2800，CAS号为 93372-87-3。
TN4036	Euparone	Others	Others
	Euparone is a benzofuran from Ruscus aculeatus L..
T80706	α-Isolupanine
	α-Isolupanine为一种生物碱，从窄叶羽扇豆（PLupinus angustifolius L.）中分离提取，应用于炭疽病研究。
TN1629	Eupalinilide C	Others	Others
	Eupalinilide C is a natural product from Impatiens balsamina L.
TN4040	Eupatoriochromene	Antifection	Microbiology/Virology
	Eupatoriochromene retard seed germination , reduced radicle and hypocotyl growth of weed and crop plant seedlings and increased adventitious root formation of mung bean cuttings. Eupatoriochromene has insecticidal activity, it exhibits toxicity againstCul
TN4038	Eupatolide	TNF; NOS; NF-κB; ROS; MAPK; Akt; COX; DNA/RNA Synthesis; Nrf2; PDGFR; NO Synthase; Prostaglandin Receptor; Autophagy	Angiogenesis; Apoptosis; Autophagy; Cell Cycle/Checkpoint; Cytoskeletal Signaling; DNA Damage/DNA Repair; GPCR/G Protein; Immunology/Inflammation; MAPK; Neuroscience; NF-κB; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	Eupatolide 是从 Inula japonica 的花中分离出来的，具有抗炎活性。 Eupatolide 可用于研究乳腺癌细胞对 TRAIL 的耐药性。
TN4258	Isocuparenal	Others	Others
	Isocuparenal 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN4258，CAS号为 16982-01-7。
TN2989	3alpha-Acetoxy-20-oxo-29-norlupane-23,28-dioic acid	Others	Others
	3alpha-Acetoxy-20-oxo-29-norlupane-23,28-dioic acid 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN2989，CAS号为 262272-76-4。
TN1632	Euparin	Antifection	Microbiology/Virology
	Euparin exhibits a moderate antioxidant activity, it also exhibits antifungal activity against Trichophyton mentagrophytes. Euparin has antiviral activity, it exerts its effect during the early events of the replication cycle, from the virus adsorption to
TN1628	Eupalinilide B	Others	Others
	Eupalinilides B demonstrates potent cytotoxicity against P-388 and A-549 tumor cell lines.
T5740	25(R,S)-Ruscogenin (25RS)鲁斯可皂苷元,(25RS)-Ruscogenin	Others; HIF	Angiogenesis; Chromatin/Epigenetic; Others
	25(R,S)-Ruscogenin 能够调节 PI3K/Akt/mTOR 信号通路，抑制 MMP-2、MMP-9、uPA、VEGF 和 HIF-1α 的表达，阻碍肝癌转移。它能够抑制 TLR4信号通路，减轻 LPS 诱导的肺内皮细胞凋亡。
TN1664	Ganoderic acid H	NF-κB; DNA/RNA Synthesis; CDK	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; NF-κB
	Ganoderic acid H 是一种羊毛脂烷型三萜，提取自灵芝中。它能够抑制转录因子AP-1 和 NF-kappaB 信号，并抑制乳腺癌细胞细胞的生长和入侵。
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天然产物

Cat.No: T5826

Target: HSP

Cat.No: T6S2238

Target: Others

Cat.No: TN3469

Synonym: 2,6-dimethoxy-4-phenylphenol

Target: NADPH-oxidase

Cat.No: TN6762

Target: Others

Cat.No: T3362

Synonym: NSC 122413,异泽兰黄素

Target: PPAR, Autophagy

Cat.No: T7032

Target: Others, P450

Cat.No: TN1630

Target: Others

Beta-Furoyleupatolide

Cat.No: TN3503

Target: Others

Cat.No: TN4035

Target: STAT

trans-2,3-Dihydro-3-ethoxyeuparin

Cat.No: TN5160

Target: Others

Adiantulupanone

Cat.No: TN5964

Eupatorin-5-methylether

Cat.No: TN4039

Target: Others

2alpha-Hydroxyeupatolide 8-O-angelate

Cat.No: TN2843

Target: Others

trans-2,3-Dihydro-3-hydroxyeuparin

Cat.No: TN5161

Target: Others

Cat.No: TN1889

Target: ERK, Akt, Topoisomerase

2-Hydroxyeupatolide

Cat.No: TN1212

Target: Others, TNF, NF-κB

20-Dehydroeupatoriopicrin semiacetal

Cat.No: TN5362

Isolupalbigenin

Cat.No: TN4308

Target: Antifection

Cat.No: TN4037

Target: Others

Cat.No: TN1631

Synonym: [3AR-[3AR*,4R*(E),6E,9S*,10E,11AR*]]-4-羟基-2-甲基-2-丁烯酸 2,3,3A,4,5,8,9,11A-八氢-9-羟基-6,10-二甲基-3-亚甲基-2-氧代环癸五烯并[B]呋喃-4-基酯,野马追内酯 K,野马追内酯K

Target: STAT

Deacetyleupaserrin

Cat.No: TN3780

Target: Others

Cat.No: TN5531

Synonym: 3,5,4'-Trihydroxy-6,7-dimethoxyflavone

Cat.No: TN4034

Target: Others

Cat.No: TN5358

Cat.No: TN6563

Cat.No: TN3899

Target: Others

3,4-Secolupa-4(23),20(29)-diene-3,28-dioic acid

Cat.No: TN2888

Target: Others

Cat.No: T82432

13β-Hydroxylupanine

Cat.No: T83452

12-Hydroxy-2,3-dihydroeuparin

Cat.No: TN2596

Target: Others

2,3-Dihydro-12,13-dihydroxyeuparin

Cat.No: TN2693

Target: Others

Cat.No: TMA0805

Target: ATPase, Potassium Channel, Calcium Channel

13-Hydroxylupanine hydrochloride

Cat.No: T83454

Synonym: Hydroxylupanine hydrochloride

Cat.No: T81653

Lupanine hydrochloride

Cat.No: T75644

Cat.No: T78477

13-Hydroxylupanine

Cat.No: TN6574

Eupatoriopicrin

Cat.No: TN4041

Target: Others

20-Hydroxy-3-oxo-28-lupanoic acid

Cat.No: TN2800

Target: Others

Cat.No: TN4036

Target: Others

Cat.No: T80706

Cat.No: TN1629

Target: Others

Eupatoriochromene

Cat.No: TN4040

Target: Antifection

Cat.No: TN4038

Target: TNF, NOS, NF-κB, ROS, MAPK, Akt, COX, DNA/RNA Synthesis, Nrf2, PDGFR, NO Synthase, Prostaglandin Receptor, Autophagy

Cat.No: TN4258

Target: Others

3alpha-Acetoxy-20-oxo-29-norlupane-23,28-dioic acid

Cat.No: TN2989

Target: Others

Cat.No: TN1632

Target: Antifection

Cat.No: TN1628

Target: Others

25(R,S)-Ruscogenin

Cat.No: T5740

Synonym: (25RS)鲁斯可皂苷元,(25RS)-Ruscogenin

Target: Others, HIF

Ganoderic acid H

Cat.No: TN1664

Target: NF-κB, DNA/RNA Synthesis, CDK

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