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Search Results for " glucose-dependent "

79

抑制剂 & 化合物

20

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T15656	KGA-2727	SGLT	GPCR/G Protein
	KGA-2727是选择性，高亲和力和口服有效的 SGLT1抑制剂，对人和大鼠 SGLT1的 Ki 分别为 97.4 nM 和 43.5 nM，对 SGLT1的选择性比人SGLT2 高 140 倍，大鼠SGLT2高390 倍。KGA-2727具有抗糖尿病活性。
T38843	Enavogliflozin DWP-16001	SGLT	GPCR/G Protein
	Enavogliflozin (DWP-16001) 是一种口服有效的，选择性的钠-葡萄糖协同转运体 -2 抑制剂，具有抗糖尿病的功效。
T9590	T-1095	SGLT; transporter	GPCR/G Protein; Metabolism
	T-1095 是一种口服有活性的Na+-葡萄糖协同转运蛋白选择性抑制剂，能够抑制 SGLT1 (IC50:22.8 µm) 及 SGLT2 (IC50:2.3 µm) 。它可用于研究糖尿病。
T2385	Ipragliflozin 伊格列净,ASP1941	SGLT	GPCR/G Protein
	Ipragliflozin (ASP1941) 是一种口服有效的，选择性的 SGLT2抑制剂，对人 SGLT2 和 SGLT1，大鼠 SGLT2 和 SGLT1，小鼠 SGLT2 和 SGLT1 的 IC50分别为 7.38 和 1876 nM，6.73 和 1166 nM，5.64 和 1380 nM。Ipragliflozin 具有抗糖尿病活性。
T1766	Empagliflozin BI 10773,恩格列净	SGLT	GPCR/G Protein
	Empagliflozin (BI 10773) 是一种 SGLT-2 抑制剂 (IC50=3.1 nM)，具有有效的和选择性，对 SGLT-1/4/5/6 的选择性高 300 倍以上。Empagliflozin 可用于治疗二型糖尿病。
T2389	Dapagliflozin 达格列净,BMS-512148	SGLT; HIF	Angiogenesis; Chromatin/Epigenetic; GPCR/G Protein
	Dapagliflozin (BMS-512148) 竞争性的葡萄糖协同转运蛋白2 (SGLT2) 抑制剂，可促进尿液中葡萄糖的排泄，在糖尿病 (DM) 研究中具有价值。Dapagliflozin 诱导 HIF1表达并减轻肾脏 IR 损伤。
T4999	Ertugliflozin 埃格列净,MK-8835,PF-04971729	SGLT	GPCR/G Protein
	Ertugliflozin (PF-04971729) 是选择性的、口服有效的钠离子依赖的葡萄糖协同转运蛋白2 (SGLT2) 抑制剂，对h-SGLT2 的IC50值为 0.877 nM。Ertugliflozin 在2型糖尿病中有研究价值。
T3547	Sotagliflozin LX-4211,LP-802034	SGLT	GPCR/G Protein
	Sotagliflozin (LP-802034) 是有效的SGLT1/2抑制剂，用作抗糖尿病剂。
T15244	Ertugliflozin L-pyroglutamic acid 埃格列净,PF-04971729 L-pyroglutamic acid	Others; SGLT	GPCR/G Protein; Others
	Ertugliflozin L-pyroglutamic acid (PF-04971729 L-pyroglutamic acid) 是一种特异性和口服活性的 hSGLT2 抑制剂，IC50 为 0.877 nM。 Ertugliflozin L-pyroglutamic acid 可用于治疗 2 型糖尿病的研究。
T5016	Tofogliflozin (hydrate) 托格列净,Tofogliflozin hydrate,CSG-452 hydrate	SGLT; Reactive Oxygen Species; ROS	GPCR/G Protein; Immunology/Inflammation; Metabolism; NF-κB
	Tofogliflozin hydrate (CSG-452 hydrate) 是一种有效的，选择性的 SGLT2抑制剂，IC50为 2.9 nM，对人、大鼠和小鼠 SGLT2的Ki 分别为 2.9 nM，14.9 nM 和 6.4 nM。Tofogliflozin hydrate 对肾小管细胞中高葡萄糖诱导的ROS 生成具有部分抑制作用。
T83694	Gastric Inhibitory Peptide (1-42) (porcine) TFA GIP (1-42),Glucose-dependent Insulinotropic Polypeptide (1-42)
	胃抑制肽(GIP) (1-42)是一种内源性的42氨基酸肽类肠促素激素，能诱导胰岛素分泌。该激素在肠道神经内分泌K细胞和颌下腺中表达，并在餐后释放到循环中。GIP (1-42)抑制由组胺、五肽和胰岛素引起的胃酸和胃蛋白酶分泌，增加葡萄糖诱导的胰岛素释放，并在大鼠中刺激胃排空。
T1782	Canagliflozin 卡格列净,JNJ 24831754ZAE,JNJ 28431754AAA,TA 7284,JNJ 28431754	SGLT	GPCR/G Protein
	Canagliflozin (JNJ 28431754AAA) 是SGLT2的选择性抑制剂，在表达 mSGLT2，rSGLT2 和 hSGLT2 的 CHO 细胞上，IC50分别为 2 nM，3.7 nM 和 4.4 nM。
T83710	Gastric Inhibitory Peptide (22-51) (human) TFA GIP (22-51),Glucose-dependent Insulinotropic Peptide (22-51)
	胃抑制肽(GIP) (22-51) 是一种具有30个氨基酸的前动脉硬化肽，对应于GIP前体蛋白proGIP的第22至51个氨基酸残基，已在人类血浆中发现。在1 µM的浓度下使用，该肽能引起在巨峰细胞分化的THP-1细胞和分离的人类主动脉内皮细胞中IκB-α的降解和NF-κB的核转移。在体内，GIP (22-51) 增加了ApoE-/-小鼠的动脉粥样硬化病变面积和斑块形成。
T83696	Gastric Inhibitory Peptide 1 (3-42) (human) TFA Glucose-dependent Insulinotropic Polypeptide 3-42,GIP-1 (3-42)
	胃抑制肽1(GIP-1) (3-42)是肠促胰岛素激素GIP的一个肽段，同时也是GIP受体的拮抗剂。它通过血清二肽基肽酶4(DDP-4)从GIP中形成。GIP-1 (3-42) (100 nM)在减少BRIN-BD11胰腺细胞的胰岛素分泌方面起作用。在以25 nmol/kg剂量给药的ob/ob糖尿病小鼠模型中，它能增加血浆葡萄糖水平并降低血浆胰岛素水平。
T4460	Dapagliflozin ((2S)-1,2-propanediol, hydrate) BMS-512148 (2S)-1,2-propanediol, hydrate,达格列净 (2S)-1,2-丙二醇水合物,Dapagliflozin propanediol monohydrate	SGLT	GPCR/G Protein
	Dapagliflozin ((2S)-1,2-propanediol, hydrate) (BMS-512148 (2S)-1,2-propanediol, hydrate) 是 Dapagliflozin 1,2-propanediol, hydrate 的 S 型异构体，是竞争性葡萄糖协同转运蛋白2 抑制剂，可促进尿液中葡萄糖的排泄，可用于糖尿病的研究。它诱导 HIF1表达并减轻肾脏 IR 损伤。
T15752	Licogliflozin LIK066	SGLT	GPCR/G Protein
	Licogliflozin (LIK066) 是钠-葡萄糖协同转运蛋白 (SGLT1和SGLT2) 的有效抑制剂。
T16083	Mizagliflozin GSK-1614235 free base,KGA-3235 free base,DSP-3235 free base	SGLT	GPCR/G Protein
	Mizagliflozin (GSK-1614235 free base) 是口服有效的、选择性的 SGLT1抑制剂，对人 SGLT1 的 Ki 值为 27 nM。Mizagliflozin 对 SGLT1 的选择性是 SGLT2的303 倍。它是抗糖尿病药物，可以改善餐后血糖波动。它在改善慢性便秘方面具有潜在的作用。
TP2018L	GIP (human) acetate GIP (human) acetate(100040-31-1 Free base)	IGF-1R	Tyrosine Kinase/Adaptors
	GIP (human) acetate 是葡萄糖依赖性胰岛素分泌的刺激剂和胃酸分泌的弱抑制剂。 GIP (human) acetate 在脂质代谢和肥胖的发展中起着至关重要的作用。
T37588L	GIP (1-30) amide, porcine acetate	IGF-1R	Tyrosine Kinase/Adaptors
	GIP (1-30) amide, porcine acetate 是完全葡萄糖依赖性促胰岛素多肽 (GIP) 受体的激动剂。它可弱抑制胃酸分泌，强烈刺激胰岛素。
TP1111	Tirzepatide LY-3298176	Glucagon Receptor	GPCR/G Protein
	Tirzepatide (LY-3298176) 是葡萄糖依赖性多肽 (GIP) 和胰高血糖素样肽-1 (GLP-1) 受体双重激动剂，具有神经保护活性，可改善血压并降低低密度脂蛋白（LDL）胆固醇和甘油三酯，可以用于研究糖尿病和肥胖症。
T76279	Retatrutide LY3437943	Glucagon Receptor	GPCR/G Protein
	Retatrutide (LY3437943) 是胰高血糖素受体、葡萄糖依赖性促胰岛素多肽受体和胰高血糖素样肽-1 受体三重激动剂,对GCGR、GIPR 和 GLP-1R 具有抑制作用。Retatrutide 可用研究肥胖症。
T16277	NCT-502 N-(4,6-dimethylpyridin-2-yl)-4-[5-(trifluoromethyl)pyridin-2-yl]piperazine-1-carbothioamide	Dehydrogenase	Metabolism
	NCT-502 (N-(4,6-dimethylpyridin-2-yl)-4-[5-(trifluoromethyl)pyridin-2-yl]piperazine-1-carbothioamide) 是磷酸甘油酸脱氢酶 (PHGDH) 抑制剂(IC50:3.7 μM)，对 PHGDH 依赖性癌细胞具有细胞毒性，能够减少葡萄糖衍生的丝氨酸的产生，。
T76279L1	Retatrutide sodium salt Retatrutide sodium salt(2381089-83-2 free base),LY3437943 sodium salt	Glucagon Receptor	GPCR/G Protein
	Retatrutide sodium salt 是一种有效的胰高血糖素受体 (GCGR)、葡萄糖依赖性促胰岛素多肽受体 (GIPR) 和胰高血糖素样肽-1 受体 (GLP-1R) 的三重激动剂肽。Retatrutide sodium salt 可用于研究2型糖尿病和肥胖症。
T69146	Suksdorfin	PPAR	DNA Damage/DNA Repair; Metabolism
	Suksdorfin 具有降血糖作用，可促进脂肪细胞分化并增强脂联素的产生，可激活过氧化物酶体增殖物激活受体 γ （PPARγ），可促进脂肪细胞对胰岛素依赖性葡萄糖的摄取，可用于肥胖相关研究。
T40413	SW157765	transporter	Metabolism
	SW157765 是一种选择性葡萄糖转运体 GLUT8（SLC2A8）抑制剂，是很多化合物的前药，以剂量依赖性方式选择性地抑制SW157765敏感细胞中荧光 2-脱氧葡萄糖（2DG）的摄取，可用于研究肺癌。
T30169	ASP-8497 UNII-GC7THT248G,ASP8497,ASP 8497
	ASP8497 is a potent, long-acting DPP-IV inhibitor that improves glucose tolerance by elevating GLP-1 levels in a glucose-dependent insulin-stimulating manner. The compound is used as a therapeutic agent for impaired glucose tolerance and type 2 diabetes.
T21399	Luseogliflozin TS71,TS-071,TS 71,TS071,TS-71,TS 071
	Luseogliflozin, a potent and competitive inhibitor of sodium-dependent glucose cotransporter 2 (SGLT2), competitively inhibits human SGLT2-mediated glucose uptake with a Ki value of 1.10 nM.
TP1566	GIP (1-30) amide (Human) (TFA)
	GIP (1-30) amide (Human) TFA is a glucose-dependent insulinotropic polypeptide fragment. Glucose-dependent insulinotropic polypeptide (GIP) is an incretin hormone that stimulates insulin secretion and reduces postprandial glycaemic excursions.
T27938	LY2922083 LY 2922083,LY-2922083
	LY2922083 is a Potent and Selective GPR40 agonist. LY2922083 demonstrates potent, efficacious and durable dose dependent reductions in glucose levels along with significant increases in insulin and GLP-1 secretion.
T40694	4-(3-Methyl-5-oxo-2-pyrazolin-1-yl)benzoic acid
	4-(3-Methyl-5-oxo-2-pyrazolin-1-yl)benzoic acid exhibits hypoglycemic activity and operates through a mechanism dependent on the response to oral glucose overload.
T34600	Secretin (1-6) Secretin,N-terminal hexapeptide
	Secretin (1-6) is the N-terminal part of secretin. It can produce vitro glucose-dependent insulin release induced by secretin.
T3074L	CHIR98014 HCl (252935-94-7 free base) CT-98014,CHIR-98014 hydrochloride,CHIR-98014,CHIR98014 HCl,CHIR98014,CHIR 98014
	CHIR98014 is a reversible, cell-permeable inhibitor of GSK3α and GSK3β (IC50s: 0.65 and 0.58 nM). Through its effects on GSK3, CHIR98014 stimulates glycogen synthase in cells (EC50: 106 nM), potentiates insulin-dependent glucose transport in isolated musc
T41028	α-Glucosidase α-D-Glucosidase,α-葡萄糖苷酶
	α-Glucosidase (α-D-Glucosidase) is a carbohydrate hydrolyzing enzyme that catalyzes the release of α-glucose from the non-reducing end of the substrate. It plays a vital role in facilitating glucose absorption by the small intestine. Inhibiting α-Glucosidase effectively manages non-insulin-dependent diabetes mellitus (NIDDM).
T68236	TP0438836
	TP0438836 is a potent, low-absorbable sodium-dependent glucose cotransporter 1 (SGLT1) inhibitor for the treatment of type 2 diabetes. TP0438836 showed IC50 values 28nM and 7 nM for hSGLT1 and hSGLT2 resepctively.
T71020	PF-04671536
	PF-04671536 is a highly potent and selective inhibitor of phosphodiesterase 8B (PDE8B) phosphodiesterase 8A (PDE8A). In primary human pancreatic islets, PF-04671536 increases insulin secretion in a glucose-dependent manner.
T12892	SGL5213	SGLT	GPCR/G Protein
	SGL5213 is an oral active and low-absorbable inhibitor of sodium-dependent glucose cotransporter 1 (SGLT1)(hSGLT1 and hSGLT2 with IC50 values of 29 nM and 20 nM , respectively),and has potential to treat type 2 diabetes.
TP1110	Tirzepatide hydrochloride LY3298176 hydrochloride
	Tirzepatide hydrochloride (LY3298176 hydrochloride) is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist.
TP2017	GIP (1-39)
	Endogenous truncated form of the incretin hormone GIP. More potent at stimulating glucose-dependent insulin secretion from rat pancreatic β-cells than GIP.
TP1584	GIP (1-30) amide,human GIP (1-30) amide (Human)
	GIP (1-30) amide (Human) is an insulin-dependent glucose-dependent polypeptide.The sugar-dependent insulin polypeptide (GIP) is an insulin secreting hormone, which can stimulate the secretion of insulin and reduce the occurrence of postpranal-glycemic dis
T24620	PF-06372222 PF-0637222,PF0637222,PF 0637222
	PF-06372222 is a small-molecule negative allosteric modulator of the glucagon receptor (GCGR). PF-06372222 is also an antagonist for glucagon-like peptide-1 receptor GLP-1R, which inhibits glucagon secretion and glucose-dependent insulin secretion.
T15797	LX2761	Others	Others
	LX2761 is a chemically stable and effective inhibitor against sodium-dependent glucose cotransporter 1 (SGLT1) and SGLT2 (IC50s: 2.2 nM and 2.7nM for hSGLT1 and hSGLT2). However, it shows specific SGLT1 inhibition in the gastrointestinal (GI) tract.
T76309	Gastric Inhibitory Peptide, porcine
	Gastric Inhibitory Peptide, porcine 为葡萄糖依赖性胰岛素促进多肽，包含42个氨基酸构成的肠道激素，对脂肪及葡萄糖代谢产生影响。
T23945	DA-11004 DA11004,UNII-48M66E9ER2
	DA-11004 is a potent NADP-dependent isocitrate dehydrogenase inhibitor (IC50: 1.49 μM for IDPc). DA-11004 inhibited fatty acid synthesis in adipose tissues via IDPc inhibition. It also decreased the plasma glucose levels and FFA in HF diet-induced obesity
T6203L	Saxagliptin hydrochloride BMS477118,Saxagliptin,BMS 477118,Saxagliptin HCl,BMS-477118
	Saxagliptin is a new oral hypoglycemic of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. Saxagliptin is a competitive DPP4 inhibitor that slows the inactivation of the incretin hormones and reducing fasting and postprandial glucose conce
T33444	MK-912 MK912,MK 912
	MK-912 is a potent novel selective alpha2-adrenergic receptor antagonist with oral activity to study the effect of short-term selective alpha2-blockers on fasting glucose (FPG) and islet function in non-insulin-dependent patients with diabetes mellitus (N
T73434	BI-2081
	BI-2081是一种GPR40 (FFAR1)部分激动剂，具有EC50值为4 nM。该化合物能诱导葡萄糖依赖性胰岛素释放，并降低血浆中葡萄糖含量，适用于研究代谢疾病，尤其是2型糖尿病。
T37589L	GIP (3-42), human acetate GIP (3-42), human acetate(1802086-25-4 Free base)	IGF-1R	Tyrosine Kinase/Adaptors
	GIP (3-42), human acetate 是葡萄糖依赖性促胰岛素多肽 (GIP) 受体的拮抗剂，可调节体内胰岛素分泌和 GIP 代谢。
T37601	GIP (1-30) amide, porcine TFA
	GIP (1-30) amide, porcine TFA is a high-affinity full agonist of the glucose-dependent insulinotropic polypeptide (GIP) receptor, having a similar potency as the native GIP(1-42) [1]. Furthermore, GIP (1-30) amide, porcine displays weak inhibitory effects on gastric acid secretion while exhibiting potent insulin-stimulating properties.
T37799	PF 04671536 hydrochloride
	Potent and selective PDE8B/8A inhibitor ( IC50 values are 1.3 and 1.9 nM, respectively). Exhibits selectivity for PDE8A/B over other PDEs (IC50 values are >10 μM) and a range of other targets. Increases glucose-dependent insulin secretion from human pacreatic islet cells. Orally bioavailable. DeNinno et al (2012) Discovery of triazolopyrimidine-based PDE8B inhibitors: exceptionally ligand-efficient and lipophilic ligand-efficient compounds for the treatment of diabetes. Bioorg.Med.Chem.Lett. 22...
T76006	Tirzepatide TFA Tirzepatide TFA(2023788-19-2 free base),LY3298176 TFA
	Tirzepatide TFA (LY3298176 TFA) 是葡萄糖依赖性胰岛素营养多肽(GIP)和胰高血糖素样肽-1(GLP-1)受体双重激动剂，有潜力用于 2 型糖尿病的研究。

化合物

Cat.No: T15656

Target: SGLT

Cat.No: T38843

Synonym: DWP-16001

Target: SGLT

Cat.No: T9590

Target: SGLT, transporter

Cat.No: T2385

Synonym: 伊格列净,ASP1941

Target: SGLT

Cat.No: T1766

Synonym: BI 10773,恩格列净

Target: SGLT

Cat.No: T2389

Synonym: 达格列净,BMS-512148

Target: SGLT, HIF

Cat.No: T4999

Synonym: 埃格列净,MK-8835,PF-04971729

Target: SGLT

Cat.No: T3547

Synonym: LX-4211,LP-802034

Target: SGLT

Ertugliflozin L-pyroglutamic acid

Cat.No: T15244

Synonym: 埃格列净,PF-04971729 L-pyroglutamic acid

Target: Others, SGLT

Tofogliflozin (hydrate)

Cat.No: T5016

Synonym: 托格列净,Tofogliflozin hydrate,CSG-452 hydrate

Target: SGLT, Reactive Oxygen Species, ROS

Gastric Inhibitory Peptide (1-42) (porcine) TFA

Cat.No: T83694

Synonym: GIP (1-42),Glucose-dependent Insulinotropic Polypeptide (1-42)

Cat.No: T1782

Synonym: 卡格列净,JNJ 24831754ZAE,JNJ 28431754AAA,TA 7284,JNJ 28431754

Target: SGLT

Gastric Inhibitory Peptide (22-51) (human) TFA

Cat.No: T83710

Synonym: GIP (22-51),Glucose-dependent Insulinotropic Peptide (22-51)

Gastric Inhibitory Peptide 1 (3-42) (human) TFA

Cat.No: T83696

Synonym: Glucose-dependent Insulinotropic Polypeptide 3-42,GIP-1 (3-42)

Dapagliflozin ((2S)-1,2-propanediol, hydrate)

Cat.No: T4460

Synonym: BMS-512148 (2S)-1,2-propanediol, hydrate,达格列净 (2S)-1,2-丙二醇水合物,Dapagliflozin propanediol monohydrate

Target: SGLT

Cat.No: T15752

Synonym: LIK066

Target: SGLT

Cat.No: T16083

Synonym: GSK-1614235 free base,KGA-3235 free base,DSP-3235 free base

Target: SGLT

GIP (human) acetate

Cat.No: TP2018L

Synonym: GIP (human) acetate(100040-31-1 Free base)

Target: IGF-1R

GIP (1-30) amide, porcine acetate

Cat.No: T37588L

Target: IGF-1R

Cat.No: TP1111

Synonym: LY-3298176

Target: Glucagon Receptor

Cat.No: T76279

Synonym: LY3437943

Target: Glucagon Receptor

Cat.No: T16277

Synonym: N-(4,6-dimethylpyridin-2-yl)-4-[5-(trifluoromethyl)pyridin-2-yl]piperazine-1-carbothioamide

Target: Dehydrogenase

Retatrutide sodium salt

Cat.No: T76279L1

Synonym: Retatrutide sodium salt(2381089-83-2 free base),LY3437943 sodium salt

Target: Glucagon Receptor

Cat.No: T69146

Target: PPAR

Cat.No: T40413

Target: transporter

Cat.No: T30169

Synonym: UNII-GC7THT248G,ASP8497,ASP 8497

Cat.No: T21399

Synonym: TS71,TS-071,TS 71,TS071,TS-71,TS 071

GIP (1-30) amide (Human) (TFA)

Cat.No: TP1566

Cat.No: T27938

Synonym: LY 2922083,LY-2922083

4-(3-Methyl-5-oxo-2-pyrazolin-1-yl)benzoic acid

Cat.No: T40694

Cat.No: T34600

Synonym: Secretin,N-terminal hexapeptide

CHIR98014 HCl (252935-94-7 free base)

Cat.No: T3074L

Synonym: CT-98014,CHIR-98014 hydrochloride,CHIR-98014,CHIR98014 HCl,CHIR98014,CHIR 98014

Cat.No: T41028

Synonym: α-D-Glucosidase,α-葡萄糖苷酶

Cat.No: T68236

Cat.No: T71020

Cat.No: T12892

Target: SGLT

Tirzepatide hydrochloride

Cat.No: TP1110

Synonym: LY3298176 hydrochloride

Cat.No: TP2017

GIP (1-30) amide,human

Cat.No: TP1584

Synonym: GIP (1-30) amide (Human)

Cat.No: T24620

Synonym: PF-0637222,PF0637222,PF 0637222

Cat.No: T15797

Target: Others

Gastric Inhibitory Peptide, porcine

Cat.No: T76309

Cat.No: T23945

Synonym: DA11004,UNII-48M66E9ER2

Saxagliptin hydrochloride

Cat.No: T6203L

Synonym: BMS477118,Saxagliptin,BMS 477118,Saxagliptin HCl,BMS-477118

Cat.No: T33444

Synonym: MK912,MK 912

Cat.No: T73434

GIP (3-42), human acetate

Cat.No: T37589L

Synonym: GIP (3-42), human acetate(1802086-25-4 Free base)

Target: IGF-1R

GIP (1-30) amide, porcine TFA

Cat.No: T37601

PF 04671536 hydrochloride

Cat.No: T37799

Tirzepatide TFA

Cat.No: T76006

Synonym: Tirzepatide TFA(2023788-19-2 free base),LY3298176 TFA

Cat. No.	Product Name	Target	Signaling Pathways
T2924	Phloretin 根皮素,Dihydronaringenin,NSC 407292,RJC 02792	SGLT; transporter; Endogenous Metabolite	GPCR/G Protein; Metabolism
	Phloretin (NSC-407292) 是从苹果树叶中提取的一种查耳酮，具有抗炎、抗氧化和抗癌活性。它是真核尿素转运蛋白抑制剂，可阻断 VacA 介导的尿素和离子转运，有潜力用于类风湿性关节炎和过敏性气道炎症的相关研究。
TN7108	Urolithin C	Apoptosis; Calcium Channel; Reactive Oxygen Species; IGF-1R; Endogenous Metabolite	Apoptosis; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; NF-κB; Tyrosine Kinase/Adaptors
	Urolithin C 属于多酚类，是鞣花酸的肠道微生物代谢产物，具有胰岛素分泌的葡萄糖依赖性激活活性。Urolithin C 是 L 型 Ca2+通道开放剂，可增强 Ca2+的流入。它通过线粒体介导的途径诱导细胞凋亡，并刺激活性氧的形成。
T2S0731	Trilobatin 三叶苷,三叶甙,P-Phlorizin	Amylase	Metabolism
	Trilobatin (P-Phlorizin) 是源自Lithocarpus polystachyusRehd 的甜味剂，是一种HIV-1抑制剂，靶向 Gp41 包膜蛋白，具有神经保护作用。它还是SGLT1/2抑制剂，可选择性诱导人肝母细胞瘤细胞增殖。
T2922	Phlorizin Floridzin,根皮甙,根皮苷,NSC 2833,Phloridzin	ATPase; SGLT	GPCR/G Protein; Membrane transporter/Ion channel
	Phlorizin (Phloridzin) 是非选择性的SGLT 抑制剂，也是Na+/K+-ATPase 抑制剂，对于hSGLT1和hSGLT2的Ki 值分别为 300 和 39 nM。
T3386	Kaempferitrin Lespedin,Kaempferol,Lespenephryl,Lespenefril,Kaempferol 3,7-dirhamnoside,山奈苷	cell cycle arrest; Glucokinase; IGF-1R	Cell Cycle/Checkpoint; Metabolism; Tyrosine Kinase/Adaptors
	Kaempferitrin (Lespenephryl) 是天然黄酮苷类化合物，具有缓解疼痛、抗糖尿病、消炎、抗肿瘤和化疗作用，可激活胰岛素信号传导。
T2P2919	(2S,3R,4S)-4-Hydroxyisoleucine (4S)-4-Hydroxy-L-isoleucine,(4S)4-羟基异亮氨酸,Hydroxyisoleucine	PI3K	PI3K/Akt/mTOR signaling
	(2S,3R,4S)-4-Hydroxyisoleucine (Hydroxyisoleucine) 是分离自胡芦巴中的一种可口服的有效成分，具有抗糖尿病、抗糖尿病肾病的作用。
T3794	Pentagalloylglucose Penta-O-galloyl-β-D-glucose,1,2,3,4,6-O-Pentagalloylglucose,1,2,3,4,6-Penta-O-galloyl-beta-D-glucopyranose,1,2,3,4,6-五没食子酰葡萄糖	Influenza Virus	Microbiology/Virology
	1,2,3,4,6-O-Pentagalloylglucose (Penta-O-galloyl-β-D-glucose) 存在于多种植物中，具有重要的药理作用。Pentagalloylglucose 表现出显著的抗狂犬病病毒 (RABV) 活性。
TWO2727	Propane-1,2,3-triyl tripalmitate Palmitic Triglyceride,Tripalmitin,Tripalmitoylglycerol,Glycerol Tripalmitate,三棕榈酸甘油酯	Others; Endogenous Metabolite	Metabolism; Others
	Propane-1,2,3-triyl tripalmitate (Glycerol Tripalmitate) 是内源性代谢产物的一种。
T2S2043	Dracorhodin perchlorate Dracorhodin perochlorate,血竭素高氯酸盐,Dracohodin perochlorate	Apoptosis; Others	Apoptosis; Others
	Dracorhodin perchlorate 是来源于中药血竭的一种天然产物。它抑制细胞生长，并以剂量和时间依赖性方式诱导成纤维细胞凋亡，将细胞周期阻滞在 G1 期，可作为抗乳腺癌的候选药物。
T5S1097	Neferine (R)-1,2-Dimethoxyaporphine,(-)-Neferine,甲基莲心碱	Apoptosis; NF-κB; Autophagy	Apoptosis; Autophagy; NF-κB
	Neferine ((-)-Neferine) 是一种双苄基异喹啉类生物碱，可强效抑制NF-κB 激活，具有抗肿瘤活性。
T5S1805	5,7-Dihydroxychromone 5,7-Dihydroxy-4H-Chromen-4-One,5,7-二羟基色酮,5,7-二羟基色原酮	Others; Virus Protease; PARP; Caspase; Nrf2	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Immunology/Inflammation; Microbiology/Virology; Others; Proteases/Proteasome
	5,7-Dihydroxychromone (5,7-Dihydroxy-4H-Chromen-4-One) 是一种Cudrania tricuspidata 的提取物，通过激活 Nrf2/ARE 信号对 6-OHDA 诱导的氧化应激和细胞凋亡发挥神经保护作用。它抑制 6-OHDA 诱导的 SH-SY5Y 细胞中活化的caspase-3，caspase-9以及切割的PARP 表达。
T5S1632	Barlerin 8-O-乙酰山栀苷甲酯,8-O-Acetylshanzhiside methyl ester,ND01	VEGFR; TNF; NF-κB; Akt; Caspase	Angiogenesis; Apoptosis; Cytoskeletal Signaling; NF-κB; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Tyrosine Kinase/Adaptors
	Barlerin (8-O-Acetylshanzhiside methyl ester) 是一种环孢菌素葡萄糖苷，从中国西藏民间药用植物中分离得到，能够抑制NF-κB 活性。
TN1847	Kushenol X 苦参醇X	Others	Others
	Kushenol X exhibits inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2).
TN1841	Kushenol A 苦参新醇 A,Leachianone E	cAMP	GPCR/G Protein
	Kushenol A is a kind of Adenosine 3', 5'-cyclic monophosphate(cAMP)phosphodiesterase inhibitiors, it shows selective alpha-glucosidase inhibitory activity. Kushenol A and kushenol C exhibit inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2).
TN3532	Borapetoside E	Others	Others
	Borapetoside E has anti-hyperglycemic activity, it can significantly reduce serum glucose levels at dose-dependent manners in alloxan-induced hyperglycemic mice and db/db type 2 diabetic mice.
TN1842	Kushenol I	GABA Receptor; Antifection	Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience
	Kushenol I is a GABAA receptor modulator, it exhibits inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2).Kushenol I is shown to be active against the plant pathogenic fungus Cladosporium cucumerinum.
TN1462	Cajanin 2',4',5-三羟基-7-甲氧基异黄酮,木豆异黄酮	ERK; MEK; Akt	Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling
	Cajanin has potential hypolipidemic effects,possibly via up-regulating the ABCA1 protein expression,subsequently resulting in increased macrophage cholesterol efflux and RCT, it can significantly improve basal glucose uptake in HepG2 cells, its improving effect is concentration dependent, it exhibits effects stronger than that of rosiglitazone, which has been used as an antidiabetic drug.
TN4399	Kushenol C	SGLT; NF-κB; ROS; BACE; Antifection	GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Neuroscience; NF-κB
	Kushenol C is a good 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenger, and it exhibits inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2). Kushenol C shows antimicrobial activity against Staphylococcus aureus and Streptococcus mutan
T74199	Beauverolide Ka
	Beauverolide Ka 是一种环四缩酚肽，是 Beauveria bassiana 真菌的代谢产物。Beauverolide Ka 浓度为 50 μM 时可刺激培养的大鼠 L6 成肌细胞的葡萄糖摄取。Beauverolide Ka 在 10 μM 时表现出对 HEI-OC1 细胞的保护作用，并且在 L6 成肌细胞和肌管中表现出剂量依赖性活性。
TN5164	trans-Hinokiresinol	IL Receptor; TNF; NOS; LTR	Apoptosis; Immunology/Inflammation
	Hinokiresinol is a novel inhibitor of LTB4 binding to the human neutrophils, it has antiallergic effect, it inhibits IgE-induced mouse passive cutaneous anaphylaxis reaction. Hinokiresinol (trans-hinokiresinol) and nyasol (cis-hinokiresinol) are estrogen

天然产物

Cat.No: T2924

Synonym: 根皮素,Dihydronaringenin,NSC 407292,RJC 02792

Target: SGLT, transporter, Endogenous Metabolite

Cat.No: TN7108

Target: Apoptosis, Calcium Channel, Reactive Oxygen Species, IGF-1R, Endogenous Metabolite

Cat.No: T2S0731

Synonym: 三叶苷,三叶甙,P-Phlorizin

Target: Amylase

Cat.No: T2922

Synonym: Floridzin,根皮甙,根皮苷,NSC 2833,Phloridzin

Target: ATPase, SGLT

Cat.No: T3386

Synonym: Lespedin,Kaempferol,Lespenephryl,Lespenefril,Kaempferol 3,7-dirhamnoside,山奈苷

Target: cell cycle arrest, Glucokinase, IGF-1R

(2S,3R,4S)-4-Hydroxyisoleucine

Cat.No: T2P2919

Synonym: (4S)-4-Hydroxy-L-isoleucine,(4S)4-羟基异亮氨酸,Hydroxyisoleucine

Target: PI3K

Pentagalloylglucose

Cat.No: T3794

Synonym: Penta-O-galloyl-β-D-glucose,1,2,3,4,6-O-Pentagalloylglucose,1,2,3,4,6-Penta-O-galloyl-beta-D-glucopyranose,1,2,3,4,6-五没食子酰葡萄糖

Target: Influenza Virus

Propane-1,2,3-triyl tripalmitate

Cat.No: TWO2727

Synonym: Palmitic Triglyceride,Tripalmitin,Tripalmitoylglycerol,Glycerol Tripalmitate,三棕榈酸甘油酯

Target: Others, Endogenous Metabolite

Dracorhodin perchlorate

Cat.No: T2S2043

Synonym: Dracorhodin perochlorate,血竭素高氯酸盐,Dracohodin perochlorate

Target: Apoptosis, Others

Cat.No: T5S1097

Synonym: (R)-1,2-Dimethoxyaporphine,(-)-Neferine,甲基莲心碱

Target: Apoptosis, NF-κB, Autophagy

5,7-Dihydroxychromone

Cat.No: T5S1805

Synonym: 5,7-Dihydroxy-4H-Chromen-4-One,5,7-二羟基色酮,5,7-二羟基色原酮

Target: Others, Virus Protease, PARP, Caspase, Nrf2

Cat.No: T5S1632

Synonym: 8-O-乙酰山栀苷甲酯,8-O-Acetylshanzhiside methyl ester,ND01

Target: VEGFR, TNF, NF-κB, Akt, Caspase

Cat.No: TN1847

Synonym: 苦参醇X

Target: Others

Cat.No: TN1841

Synonym: 苦参新醇 A,Leachianone E

Target: cAMP

Cat.No: TN3532

Target: Others

Cat.No: TN1842

Target: GABA Receptor, Antifection

Cat.No: TN1462

Synonym: 2',4',5-三羟基-7-甲氧基异黄酮,木豆异黄酮

Target: ERK, MEK, Akt

Cat.No: TN4399

Target: SGLT, NF-κB, ROS, BACE, Antifection

Beauverolide Ka

Cat.No: T74199

trans-Hinokiresinol

Cat.No: TN5164

Target: IL Receptor, TNF, NOS, LTR

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