Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Kushenol X exhibits inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2).
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
5 mg | ¥ 14,800 | 待询 | ||
1 mL * 10 mM (in DMSO) | ¥ 17,800 | 待询 |
产品描述 | Kushenol X exhibits inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2). |
靶点活性 | β-glucuronidase:2.07 μM (IC50), CES2A (human):3.05 μM (IC50) |
体外活性 | Sixteen lavandulyl flavonoids were isolated and their structures were elucidated as kushenol H(1),kushenol K(2),kurarinol(3),kushenol Y(4),kushenol P(5),norkurarinone(6),kushenol I(7),kushenol N(8),(-)-kurarinone(9),Kushenol X(10),neokurarinol(11),kushenol C(12),sophoraflavanone G(13),leachianone A(14),kuraridine(15)and kushenol A(16). All isolated compounds exhibited inhibitory activity against SGLT2. Among them,the two main constituents of the active EtOAc fraction,(-)-kurarinone(9)and sophoraflavanone G(13)showed the most potential inhibitory activity against SGLT2with the IC50values of 2.24μmol/L and 1.45μmol/L,respectively. |
别名 | 苦参醇X |
分子量 | 440.49 |
分子式 | C25H28O7 |
CAS No. | 254886-77-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Kushenol X 254886-77-6 Others 苦参醇X Inhibitor inhibitor inhibit