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Search Results for " pde "

Targets Recommended: PDE PDE

202

抑制剂 & 化合物

24

天然产物

1

TargetMol 试剂盒

10

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Cat. No.	Product Name	Form	Specificity Of Inhibition
CL0064	PDE inhibitor kit PDE inhibitor kit

TargetMol 试剂盒

PDE inhibitor kit

Cat.No: CL0064

Cat. No.	Product Name	Target	Signaling Pathways
T10201	PDE IV-IN-1	PDE	Metabolism
	PDE IV-IN-1 是一种有效的磷酸二酯酶4 (PDE4)抑制剂，具有抗炎活性，可用于治疗哮喘，慢性阻塞性肺病和其他炎症性疾病，是研究抑郁症的潜在化合物。
T68191	PDE-I2
	PDE-I2 is a parasite schizogony inhibitor.
T12395	PDE9-IN-1	PDE	Metabolism
	PDE9-IN-1 是一种选择性和口服生物可利用的 PDE9A 抑制剂（IC50 为 8.7 nM）。
T12389	PDE-9 inhibitor	Others	Others
	PDE-9 inhibitor is used for treatment neurodegenerative diseases.
T8659	K-Ras-PDEδ-IN-1	PDE	Metabolism
	K-Ras-PDEδ-IN-1 是新型的 K-Ras-PDEδ 抑制剂，它能够以低纳摩尔Kd8 nM 与 PDEδ 的法尼基结合袋竞争性结合。
T36832	PDE4B-IN-2 A 33	PDE	Metabolism
	PDE4B-IN-2 (A 33) 是一种具有口服活性，选择性 PDE4B 抑制剂，IC50 为 15 nM。PDE4B-IN-2 抑制 PDE4D (IC50=1.7 µM)。PDE4B-IN-2 表现出有效的抗炎作用。
T21965	MBCQ	PDE	Metabolism
	MBCQ 是选择性 cGMP 特异性磷酸二酯酶 (PDE V; PDE5) 抑制剂，IC50=19 nM。它通过特异性抑制 cGMP-PDE 来扩张冠状动脉。它对其他 PDE 同工酶没有抑制活性，IC50均大于 100 µM。
T5411	PDE10-IN-1 SEP-0372814	PDE	Metabolism
	PDE10-IN-1 (SEP-0372814) 是一种高效的 PDE10抑制剂。
T6462	Deltarasin	PDE; Ras	GPCR/G Protein; MAPK; Metabolism
	Deltarasin 是一种 KRAS-PDEδ 相互作用的小分子抑制剂，与纯化的 PDEδ 结合，Kd 值为 38 nM。
T40356	PDE4-IN-3 PDE4-IN-3
	PDE4-IN-3 is a newly developed oral compound that acts as a potent inhibitor of the enzyme phosphodiesterase 4 (PDE4), displaying a high affinity for inhibition with an IC50 value of 4.2 nM.
T2129	Zaprinast	PDE	Metabolism
	Zaprinast 是一种 cGMP 选择性的磷酸二酯酶(PDE)抑制剂，是一种 GPR35激动剂，对大鼠 GPR35 有很强的激活作用，对人 GPR35 有一定的激活作用。它通过抗增殖和促凋亡作用，减少血管的重构。
T39210	PDE4-IN-4 PDE4-IN-4
	PDE4-IN-4 is a compound acting as both a potent M3 antagonist (p IC 50 = 10.2) and a PDE4 inhibitor (p IC 50 = 8.8), designed for inhalation-based treatment of pulmonary diseases.
T40278	PDE2A-IN-1 PDE2A-IN-1
	PDE2A-IN-1 is a phosphodiesterase 2A (PDE2A) inhibitor with an IC 50 value of 1.3 nM.
T39796	PDE12-IN-1 PDE12-IN-1
	PDE12-IN-1 is a powerful and specific inhibitor of PDE12, exhibiting a pIC 50 value of 9.1 for enzyme inhibition. It effectively enhances levels of 2′,5′-linked adenylate polymers (2-5A), with a pEC 50 value of 7.7. Additionally, PDE12-IN-1 demonstrates antiviral activity.
T6054	GSK256066	PDE	Metabolism
	GSK256066 是高亲和力的、选择性的PDE4抑制剂，IC50=3.2 pM，被开发用于慢性阻塞性肺病的研究。
T10676	Carbodenafil	PDE	Metabolism
	Carbodenafil 是在健康食品中发现的 Sildenafil 相关化合物。其中Sildenafil 是磷酸二酯酶 5 (PDE5) 抑制剂(IC50:5.22 nM)。
T67941	PDE5-IN-9
	PDE5-IN-9对Phosphodiesterase PDE1c 具有抑制作用，可用来治疗高血压、心力衰竭、心肌梗塞、肾衰竭、哮喘、支气管炎和痴呆。
T5496	ML-030	PDE	Metabolism
	ML-030 是 PDE4抑制剂，对 PDE4A (IC50=6.7 nM)，PDE4A1 (IC50=12.9 nM)，PDE4B1 (IC50=48.2 nM)，PDE4B2 (IC50=37.2 nM)，PDE4C1 (IC50=452 nM) 和 PDE4D2 (IC50=49.2 nM)。
T13448	(R)-(-)-Rolipram (R)-Rolipram,(-)-Rolipram	DNA-PK; Others	DNA Damage/DNA Repair; Others; PI3K/Akt/mTOR signaling
	(R)-(-)-Rolipram ((-)-Rolipram) 是一种 PDE4 抑制剂 Rolipram 的 R-对映异构体。
T4695	CP671305	PDE	Metabolism
	CP671305 是口服具有活力的 phosphodiesterase-4-D 选择性抑制剂，具有很高的活性。
T4462	Roflumilast N-oxide	PDE	Metabolism
	Roflumilast N-oxide 是一种 PDE 4 型抑制剂。
T2646	HA130	PDE	Metabolism
	HA130 是选择性 autotaxin 抑制剂，IC50=28 nM。
T27172	Difamilast	PDE	Metabolism
	Difamilast 是局部的、选择性的非甾体磷酸二酯酶 4 抑制剂，对 B 亚型抑制作用较好 (IC50=11.2 nM)。它在研究轻度至中度特应性皮炎方面有研究的价值。
T7888	Enpp-1-IN-1	PDE	Metabolism
	Enpp-1-IN-1 是enpp-1(核苷酸焦磷酸酶-磷酸二酯酶 1) 选择性抑制剂。
T10410	ATX inhibitor 1	PDE	Metabolism
	ATX inhibitor 1是一种 ATX(IC50=1.23 nM, FS-3; 2.18 nM, bis-pNPP) 抑制剂。
T7346	Lodenafil Hydroxyhomosildenafil,羟基豪莫西地那非	PDE	Metabolism
	Lodenafil (Hydroxyhomosildenafil) 是一种有效的磷酸二酯酶 5 型(PDE5)抑制剂，可用于勃起功能障碍的研究。
T10590	Zatolmilast BPN14770	Others; PDE	Metabolism; Others
	Zatolmilast (BPN14770) 是选择性磷酸二酯酶 4D(PDE4D)变构抑制剂，能够抑制 PDE4D7 (IC50:7.8 nM) 与 PDE4D3 (IC50:7.4 nM)。
T6548	Irsogladine Dicloguamine,伊索拉定	PDE; AChR	Metabolism; Neuroscience
	Irsogladine (Dicloguamine) 是抗胃溃疡剂，通过 M1 毒蕈碱乙酰胆碱受体结合促进间隙连接细胞间通讯。
T5106	BRL-50481	PDE	Metabolism
	BRL 50481 是一种新型的、选择性的 PDE7 的抑制剂，对 PDE7A，PDE7B，PDE4和 PDE3的 IC50值分别为 0.15，12.1，62 和 490 μM。
T3631	PF-8380	PDE	Metabolism
	PF8380 是有效的autotaxin 抑制剂，在体外酶实验和人类全血细胞实验中的IC50分别为 2.8 nM 和 101 nM。
T8515	Osoresnontrine BI-409306	PDE	Metabolism
	Osoresnontrine (BI-409306) 是选择性的PDE9A 抑制剂，IC50=52 nM，对其他 PDE 的活性较弱。它可用于中枢神经系统障碍疾病中提高记忆力的研究。
T12267	NSP-805	PDE	Metabolism
	NSP-805 是一种强心剂，是一种选择性的 phosphodiesterase 3 抑制剂，具有舒张血管的作用。
T1618	Dipyridamole Persantin,Dypyridamole,Dipyridamol,双嘧达莫,NSC-515776,Dipyudamine	PDE	Metabolism
	Dipyridamole (Persantin) 是一种磷酸二酯酶抑制剂，能阻断红细胞和血管内皮细胞对腺苷的吸收和代谢。
T1096	Milrinone Win 47203,米力农	PDE	Metabolism
	Milrinone (Win 47203) 是一种 PDE3抑制剂，也是一种强心药、血管舒张药。
T7542	Amino Tadalafil 氨基他达那非,氨基他达拉非	PDE	Metabolism
	Amino Tadalafil 是一种 Tadalafil 的类似物，是一种磷酸二酯酶 5 抑制剂，可用于多种疾病，如勃起功能障碍，肺动脉高压和下尿路功能障碍。
T11689	ITI-214 ITI214	PDE	Metabolism
	ITI-214 是一种中枢神经系统活性抑制剂，具有口服生物活性的PDE1抑制剂 (Kiof 58 pM)，对其他 PDE 家族成员和一系列酶、受体、转运体和离子通道具有良好的选择性，在各种运动和认知功能的动物模型中显示出有效性。
T5474	D159687 D 159687	PDE	Metabolism
	D159687 是一种PDE4D 选择性抑制剂。
T12150	N-Methylbenzamide	PDE	Metabolism
	N-Methylbenzamide 是磷酸二酯酶 10A 抑制剂，具有抗癌作用。
T1745	Balipodect TAK063,TAK-063,TAK 063	PDE	Metabolism
	Balipodect (TAK063) 是一种高效的、口服具有活性、选择性的 PDE10A 抑制剂，IC50=0.3nM，对其他PDEs 无抑制作用。
T23154	Piclamilast RPR 73401,RP 73401,吡拉米司特	PDE	Metabolism
	Piclamilast (RP 73401) 是一种有效的磷酸二酯酶 4(PDE4)的抑制剂，对猪主动脉和可溶性嗜酸性粒细胞中的 IC50值分别为 16 nM 和 2 nM。
T4041	Ziritaxestat GLPG1690	PDE	Metabolism
	Ziritaxestat (GLPG1690) 是一种创新的 autotaxin (ATX)抑制剂，其 IC50=131 nM，Ki=15 nM。
T6147	Nortadalafil Demethyl Tadalafil,去甲基他达那非	PDE	Metabolism
	Nortadalafil (Demethyl Tadalafil) 是 demethyl Tadalafil，是一种 PDE5 抑制剂。
T21865	BC 11-38	PDE	Metabolism
	BC 11-38是一种有效的PDE11生物活性抑制剂，可提高PKA 介导的 ATF-1 磷酸化、 H295R 细胞 cAMP 水平和皮质醇生成。
T8405	Vardenafil hydrochloride 伐地那非,盐酸伐地那非	PDE	Metabolism
	Vardenafil hydrochloride 是口服具有活性的、高效的、选择性的磷酸二酯酶 5抑制剂。它对 PDE1 (180 nM)，PDE6 (11 nM)，PDE2，PDE3，PDE4 (>1000 nM) 具有选择性。它能够非竞争性地抑制环磷酸鸟苷水解，提高 cGMP 水平。它可用于勃起功能障碍的研究。
T9805	BAY 2666605	PDE	Metabolism
	BAY 2666605 是一种具有口服活性的 PDE3A 和 PDE3B 抑制剂，IC50 分别为 87 nM 和 50 nM。 BAY 2666605 具有抗癌作用。
T12913	Siguazodan SKF 94836	PDE	Metabolism
	Siguazodan (SKF 94836) 是选择性的，口服有效的磷酸二酯酶 III 抑制剂，IC50为 117 nM。它可增加完整血小板中 cAMP 的积累，EC50为 18.88 μM。它也抑制苯肾上腺素诱导的 5-HT 释放，IC50为 4.2 μM。
T8919	Homo Sildenafil 蒙莫西地那非,豪莫西地那非	PDE	Metabolism
	Homo Sildenafil 是一种 Sildenafil 的类似物，是一种磷酸二酯酶抑制剂。
T5033	Olprinone 奥普力农,Loprinone	PDE	Metabolism
	Olprinone (Loprinone) 是一种有效的磷酸二酯酶(PDE) 3抑制剂，对 PDE1，PDE2，PDE3，PDE4 的IC50分别为 150、100、0.35 和 14 μM，具有抗炎活性。它具有正性肌力和血管扩张作用，可用于心力衰竭的研究。
T8506	THPP-1	PDE	Metabolism
	THPP-1 是一种 SGC 推荐的化学探针，是一种口服具有活性的磷酸二酯酶10A 抑制剂，其对人和大鼠的Ki 分别为 1 nM 和 1.3 nM。它的药理学特性良好。
T16499	Mardepodect PF-2545920	PDE	Metabolism
	Mardepodect (PF-2545920) 是一种有效的、口服具有活性的、可透过血脑屏障的、选择性的 PDE10A 抑制剂，IC50=0.37 nM，比作用于其他 PDE 选择性高 1000 多倍。

化合物

Cat.No: T10201

Target: PDE

Cat.No: T68191

Cat.No: T12395

Target: PDE

PDE-9 inhibitor

Cat.No: T12389

Target: Others

K-Ras-PDEδ-IN-1

Cat.No: T8659

Target: PDE

Cat.No: T36832

Synonym: A 33

Target: PDE

Cat.No: T21965

Target: PDE

Cat.No: T5411

Synonym: SEP-0372814

Target: PDE

Cat.No: T6462

Target: PDE, Ras

Cat.No: T40356

Synonym: PDE4-IN-3

Cat.No: T2129

Target: PDE

Cat.No: T39210

Synonym: PDE4-IN-4

Cat.No: T40278

Synonym: PDE2A-IN-1

Cat.No: T39796

Synonym: PDE12-IN-1

Cat.No: T6054

Target: PDE

Cat.No: T10676

Target: PDE

Cat.No: T67941

Cat.No: T5496

Target: PDE

(R)-(-)-Rolipram

Cat.No: T13448

Synonym: (R)-Rolipram,(-)-Rolipram

Target: DNA-PK, Others

Cat.No: T4695

Target: PDE

Roflumilast N-oxide

Cat.No: T4462

Target: PDE

Cat.No: T2646

Target: PDE

Cat.No: T27172

Target: PDE

Cat.No: T7888

Target: PDE

ATX inhibitor 1

Cat.No: T10410

Target: PDE

Cat.No: T7346

Synonym: Hydroxyhomosildenafil,羟基豪莫西地那非

Target: PDE

Cat.No: T10590

Synonym: BPN14770

Target: Others, PDE

Cat.No: T6548

Synonym: Dicloguamine,伊索拉定

Target: PDE, AChR

Cat.No: T5106

Target: PDE

Cat.No: T3631

Target: PDE

Cat.No: T8515

Synonym: BI-409306

Target: PDE

Cat.No: T12267

Target: PDE

Cat.No: T1618

Synonym: Persantin,Dypyridamole,Dipyridamol,双嘧达莫,NSC-515776,Dipyudamine

Target: PDE

Cat.No: T1096

Synonym: Win 47203,米力农

Target: PDE

Amino Tadalafil

Cat.No: T7542

Synonym: 氨基他达那非,氨基他达拉非

Target: PDE

Cat.No: T11689

Synonym: ITI214

Target: PDE

Cat.No: T5474

Synonym: D 159687

Target: PDE

N-Methylbenzamide

Cat.No: T12150

Target: PDE

Cat.No: T1745

Synonym: TAK063,TAK-063,TAK 063

Target: PDE

Cat.No: T23154

Synonym: RPR 73401,RP 73401,吡拉米司特

Target: PDE

Cat.No: T4041

Synonym: GLPG1690

Target: PDE

Cat.No: T6147

Synonym: Demethyl Tadalafil,去甲基他达那非

Target: PDE

Cat.No: T21865

Target: PDE

Vardenafil hydrochloride

Cat.No: T8405

Synonym: 伐地那非,盐酸伐地那非

Target: PDE

Cat.No: T9805

Target: PDE

Cat.No: T12913

Synonym: SKF 94836

Target: PDE

Homo Sildenafil

Cat.No: T8919

Synonym: 蒙莫西地那非,豪莫西地那非

Target: PDE

Cat.No: T5033

Synonym: 奥普力农,Loprinone

Target: PDE

Cat.No: T8506

Target: PDE

Cat.No: T16499

Synonym: PF-2545920

Target: PDE

Cat. No.	Product Name	Target	Signaling Pathways
TN1266	3-O-Methylquercetin	IL Receptor; cAMP; PDE	GPCR/G Protein; Immunology/Inflammation; Metabolism
	3-O-Methylquercetin 是分离自植物Rhamnus nakaharai 的天然产物，可抑制总 cAMP 和cGMP-phosphodiesterase (PDE)。它对PDE1、PDE5、PDE 和PDE4的IC50分别是31.9 μM、86.9 μM、18.6 μM 和1.6 μM。
T8787	Drotaverine hydrochloride	PDE	Metabolism
	Drotaverine hydrochloride 是磷酸二酯酶 4 (PDE4)的抑制剂，也是 L 型电压依赖钙通道(L-VDCC)的阻滞剂，可阻断3',5'-环腺苷单磷酸的降解。它在体内有抗痉挛效果，但无抗胆碱能的效果。
TN1416	Ayanin	IL Receptor; P450; PARP; PDE	Chromatin/Epigenetic; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism
	Ayanin 是从Croton schiedeanus Schlecht 中分离得到的黄酮类物质。它是非选择性的磷酸二酯酶抑制剂，在呼吸道疾病中有研究的价值，如过敏性哮喘等。
T1681	Aminophylline 氨茶碱,Phyllocontin	PDE; Adenosine Receptor	GPCR/G Protein; Metabolism; Neuroscience
	Aminophylline (Phyllocontin) 是一种竞争性非选择性磷酸二酯酶抑制剂，具有支气管扩张作用。它是竞争性的腺苷受体拮抗剂，有用于哮喘研究的潜力。
T7027	EURYCOMANONE 东革阿里提取物,Pasakbumin A	Others	Others
	Eurycomanone (Pasakbumin A) 能够抑制雌激素生成过程中磷酸二酯酶和芳香酶的活性，促进精子生成。它对 HepG2 细胞具有细胞毒性，能够上调 p53 和 Bax 以及下调 Bcl-2 ，诱导细胞凋亡。它具有抗癌活性，在浓度范围内以剂量依赖性方式抑制 A549 肺癌细胞增殖从 5 到 20 微克/毫升。
T2855	Icariin 淫羊藿苷,Ieariline,淫羊藿甙	PDE; PPAR; Autophagy	Autophagy; DNA Damage/DNA Repair; Metabolism
	Icariin (Ieariline) 是一种黄酮醇苷，可抑制PDE5和PDE4活性，IC50分别为 432 nM 和 73.50 μM。它也是PPARα激活剂。
T0892	Diphylline 二羟丙茶碱,Dyphylline,Diprophylline	PDE; Adenosine Receptor	GPCR/G Protein; Metabolism; Neuroscience
	Diphylline (Diprophylline) 是一种A1/A2腺苷受体拮抗剂，也是环状核苷酸磷酸二酯酶抑制剂。它是一种黄嘌呤衍生物，具有支气管扩张和血管扩张作用，有用于治疗慢性支气管炎和肺气肿的潜力。
T3783	Fraxin Fraxoside,Fraxetin-8-O-glucoside,Paviin,秦皮甙	OAT; transporter; PDE	Membrane transporter/Ion channel; Metabolism
	Fraxin (Fraxoside) 是一种白蜡树内酯的糖苷，可从Acer tegmentosum，F. ornus 和A. hippocastanum 等分离得到，具有抗氧化、抗炎和抗转移活性。它能够抑制环腺苷酸磷酸二酯酶，具有抗氧化作用。
T0480	Doxofylline Doxophylline,多索茶碱	PDE; Adenosine Receptor	GPCR/G Protein; Metabolism; Neuroscience
	Doxofylline (Doxophylline) 是腺苷 A1 受体拮抗剂，且能抑制磷酸二酯酶 IV，用于治疗哮喘。
T1083	Theophylline Theo-24,1,3-Dimethylxanthine,茶碱	Endogenous Metabolite; HDAC; PDE; Adenosine Receptor; Autophagy	Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; GPCR/G Protein; Metabolism; Neuroscience
	Theophylline (1,3-Dimethylxanthine) 是茶中的甲基黄嘌呤衍生物，具有利尿、平滑肌松弛、支气管扩张、心脏和中枢神经系统兴奋作用。
TN2159	Robustine 大叶桉亭,8-羟基白鲜碱,4-甲氧基呋喃并[2,3-B]喹啉-8-醇	PDE	Metabolism
	Robustine 是一种从 Dictamnus albus 获得的呋喃喹啉生物碱，在体外对人磷酸二酯酶 5 (hPDE5A) 具有抑制作用。
T6427	Butein 2’,3,4,4’-tetrahydroxy Chalcone,紫铆因	Apoptosis; EGFR; Others; PDE; Autophagy	Angiogenesis; Apoptosis; Autophagy; JAK/STAT signaling; Metabolism; Others; Tyrosine Kinase/Adaptors
	Butein (2’,3,4,4’-tetrahydroxy Chalcone) 是一种 cAMP 特异性PDE 抑制剂，也是蛋白酪氨酸激酶抑制剂，还是一种SIRT1激活剂。它通过 AKT 和 ERK/p38 MAPK 通路，靶向 FoxO3a 使 HeLa 细胞对 Cisplatin 敏感。
T5S2059	Glaucine	Calcium Channel; Dopamine Receptor; Influenza Virus; Adrenergic Receptor; PDE	GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience
	Glaucine 是从海罂粟中分离的一种生物碱，具有镇咳、抗炎和支气管扩张作用。它是具有口服活性的磷酸二酯酶 4 选择性抑制剂。它还是非选择性的 α-肾上腺素受体拮抗剂，具有抗氧化和抗病毒活性。
T2205	Acefylline Theophylline-7-acetic acid,茶碱乙酸,Carboxymethyltheophylline,acetyloxytheophylline,Theophyllineacetic acid	TNF; PAD; PKA; HDAC; PDE; Adenosine Receptor	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; GPCR/G Protein; Metabolism; Neuroscience; Tyrosine Kinase/Adaptors
	Acefylline (Theophylline-7-acetic acid) 是黄嘌呤衍生物，是一种腺苷受体拮抗剂。它是蛋白质精氨酸脱亚氨酶 (PAD) 激活剂，也是一种支气管扩张剂，可抑制大鼠肺 cAMP 磷酸二酯酶同工酶。
T0167	Vinpocetine 长春西丁,RGH-4405,长春西汀,Ethyl apovincaminate	IκB/IKK; NF-κB; Sodium Channel; PDE	Membrane transporter/Ion channel; Metabolism; NF-κB
	Vinpocetine (RGH-4405) 是一种长春花生物碱衍生物，是阻断 Na+通道的阻断剂。Vinpocetine 抑制IKK 的IC50为 17.17 μM。Vinpocetine 也是PDE 抑制剂，并通过直接靶向IKK 抑制NF-κB 依赖性炎症反应，已被广泛用于研究脑血管疾病。
T17199	Udenafil 3-(6,7-二氢-1-甲基-7-氧代-3-丙基-1H-吡唑并[4,3-D]嘧啶-5-基)-N-[2-(1-甲基-2-吡咯烷基)乙基]-4-丙氧基苯磺酰胺,乌地那非	PDE	Metabolism
	Udenafil 是一种选择性的，有效的，具有口服活性的 5 型磷酸二酯酶 (PDE5) 抑制剂。它能够抑制 cGMP 水解，可用于研究勃起功能障碍的。
T0070	Pentoxifylline Oxpentifylline,PTX,己酮可可碱,BL-191	HIV Protease; PDE; Adenosine Receptor; Autophagy	Autophagy; GPCR/G Protein; Metabolism; Microbiology/Virology; Neuroscience; Proteases/Proteasome
	Pentoxifylline (PTX) 是一种具有口服活性的磷酸二酯酶非选择性抑制剂，具有免疫调节、抗炎、抗纤溶、抗增殖和血液流变学改善作用。它可研究周围血管疾病、脑血管疾病和其他一些涉及局部微循环缺陷的疾病。
TN2217	Sophoflavescenol 槐苦参醇,槐黄醇	Others; Beta-Secretase; BACE; PDE; AChR; AChE	Metabolism; Neuroscience; Others
	Sophoflavescenol 是异戊烯基黄酮类化合物，能够抑制PDE5的活性，IC50=0.013 μM。它也抑制 RLAR，HRAR，BACE1，AChE 和 BChE，IC50值分别为 0.30 µM，0.17 µM，10.98 µM，8.37 µM 和 8.21 µM。
T1027	Luteolin 木犀草素,Luteolol,Flacitran,Digitoflavone,Luteoline	Apoptosis; Nrf2; Endogenous Metabolite; PDE; Autophagy	Apoptosis; Autophagy; Immunology/Inflammation; Metabolism
	Luteolin (Luteolol) 属于黄酮类天然产物，是一种 Nrf2 抑制剂、PDE 抑制剂。Luteolin 具有多种生物活性，包括抗肿瘤、抗氧化、抗炎、抗菌、抗病毒、抗过敏和促凝血等。
T5940	Proxyphylline 羟丙茶碱,7-(2-Hydroxypropyl)theophylline	PDE; Adenosine Receptor	GPCR/G Protein; Metabolism; Neuroscience
	Proxyphylline (7-(2-Hydroxypropyl)theophylline) 是甲基黄嘌呤衍生物，可用作心脏活化剂、血管扩张剂和支气管扩张剂。
TN4317	Isopedicin	NADPH-oxidase; cAMP; p38 MAPK; PKA; JNK; PDE	GPCR/G Protein; Immunology/Inflammation; MAPK; Metabolism; Tyrosine Kinase/Adaptors
	Isopedicin has anti-inflammatory functions, it inhibits the O(2)()(-) production in human neutrophils by an elevation of cellular cAMP and activation of PKA through its inhibition of cAMP-specific PDE*.
TN2974	3-O-Methylquercetin tetraacetate	IL Receptor; TNF; PDE	Apoptosis; Immunology/Inflammation; Metabolism
	Quercetin 3-O-methyl ether is a potent phosphodiesterase (PDE)3/4 inhibitor, it has potential for treating asthma against ovalbumin-induced airway hyperresponsiveness.
TN4398	Kushenol B	Others	Others
	Kushenol B 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN4398，CAS号为 99217-64-8。
T16397	Ophiobolin A	Others	Others
	Ophiobolin A is a fungal metabolite and a phytotoxin and is an effective and irreversibly inhibitor of calmodulin-activated cyclic nucleotide phosphodiesterase (IC50: 9 μM). Ophiobolin A also has antimicrobial and anticancer activity.

天然产物

3-O-Methylquercetin

Cat.No: TN1266

Target: IL Receptor, cAMP, PDE

Drotaverine hydrochloride

Cat.No: T8787

Target: PDE

Cat.No: TN1416

Target: IL Receptor, P450, PARP, PDE

Cat.No: T1681

Synonym: 氨茶碱,Phyllocontin

Target: PDE, Adenosine Receptor

Cat.No: T7027

Synonym: 东革阿里提取物,Pasakbumin A

Target: Others

Cat.No: T2855

Synonym: 淫羊藿苷,Ieariline,淫羊藿甙

Target: PDE, PPAR, Autophagy

Cat.No: T0892

Synonym: 二羟丙茶碱,Dyphylline,Diprophylline

Target: PDE, Adenosine Receptor

Cat.No: T3783

Synonym: Fraxoside,Fraxetin-8-O-glucoside,Paviin,秦皮甙

Target: OAT, transporter, PDE

Cat.No: T0480

Synonym: Doxophylline,多索茶碱

Target: PDE, Adenosine Receptor

Cat.No: T1083

Synonym: Theo-24,1,3-Dimethylxanthine,茶碱

Target: Endogenous Metabolite, HDAC, PDE, Adenosine Receptor, Autophagy

Cat.No: TN2159

Synonym: 大叶桉亭,8-羟基白鲜碱,4-甲氧基呋喃并[2,3-B]喹啉-8-醇

Target: PDE

Cat.No: T6427

Synonym: 2’,3,4,4’-tetrahydroxy Chalcone,紫铆因

Target: Apoptosis, EGFR, Others, PDE, Autophagy

Cat.No: T5S2059

Target: Calcium Channel, Dopamine Receptor, Influenza Virus, Adrenergic Receptor, PDE

Cat.No: T2205

Synonym: Theophylline-7-acetic acid,茶碱乙酸,Carboxymethyltheophylline,acetyloxytheophylline,Theophyllineacetic acid

Target: TNF, PAD, PKA, HDAC, PDE, Adenosine Receptor

Cat.No: T0167

Synonym: 长春西丁,RGH-4405,长春西汀,Ethyl apovincaminate

Target: IκB/IKK, NF-κB, Sodium Channel, PDE

Cat.No: T17199

Synonym: 3-(6,7-二氢-1-甲基-7-氧代-3-丙基-1H-吡唑并[4,3-D]嘧啶-5-基)-N-[2-(1-甲基-2-吡咯烷基)乙基]-4-丙氧基苯磺酰胺,乌地那非

Target: PDE

Cat.No: T0070

Synonym: Oxpentifylline,PTX,己酮可可碱,BL-191

Target: HIV Protease, PDE, Adenosine Receptor, Autophagy

Sophoflavescenol

Cat.No: TN2217

Synonym: 槐苦参醇,槐黄醇

Target: Others, Beta-Secretase, BACE, PDE, AChR, AChE

Cat.No: T1027

Synonym: 木犀草素,Luteolol,Flacitran,Digitoflavone,Luteoline

Target: Apoptosis, Nrf2, Endogenous Metabolite, PDE, Autophagy

Cat.No: T5940

Synonym: 羟丙茶碱,7-(2-Hydroxypropyl)theophylline

Target: PDE, Adenosine Receptor

Cat.No: TN4317

Target: NADPH-oxidase, cAMP, p38 MAPK, PKA, JNK, PDE

3-O-Methylquercetin tetraacetate

Cat.No: TN2974

Target: IL Receptor, TNF, PDE

Cat.No: TN4398

Target: Others

Cat.No: T16397

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02081	PDE2A Protein, Human, Recombinant (aa 215-900, His) phosphodiesterase 2A, cGMP-stimulated,cGSPDE,PED2A4...	Human	Baculovirus Insect Cells
	cGMP-dependent 3',5'-cyclic phosphodiesterase, also known as cyclic GMP-stimulated phosphodiesterase and PDE2A, is a peripheral membrane protein that belongs to the cyclic nucleotide phosphodiesterase family and PDE2 subfamily. Phosphodiesterases (PDEs) comprise a family of enzymes that regulate the levels of cyclic nucleotides, key second messengers that mediate a diverse array of functions. Phosphodiesterases (PDEs) modulate signaling by cyclic nucleotides in diverse processes such as cardiac ...
TMPY-01588	ALDH7A1 Protein, Human, Recombinant (His) ATQ1,aldehyde dehydrogenase 7 family, member A1,EPD,PDE<...	Human	E. coli
	ALDH7A1 (Aldehyde dehydrogenase 7 family, member A1) is a member of subfamily 7 in the aldehyde dehydrogenase family. These enzymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. Mammalian ALDH7A1 is homologous to plant ALDH7B1 which protects against various forms of stress such as increased salinity, dehydration and treatment with oxidants or pesticides. In mammals, ALDH7A1 is known to play a primary role during lysine...
TMPY-01922	PDE9A Protein, Human, Recombinant (His & GST) HSPDE9A2,phosphodiesterase 9A	Human	Baculovirus Insect Cells
	PDE9A Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 89.5 kDa and the accession number is O76083-2.
TMPH-02706	PDE9A Protein, Mouse, Recombinant (His)	Mouse	E. coli
	PDE9A Protein, Mouse, Recombinant (His) is expressed in E. coli.
TMPY-01921	PDE9A Protein, Human, Recombinant (His) phosphodiesterase 9A,HSPDE9A2	Human	E. coli
	PDE9A Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 40 kDa and the accession number is O76083-2.
TMPH-02575	PDE5A Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP. Specifically regulates nitric-oxide-generated cGMP. PDE5A Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 26.1 kDa and the accession number is Q8CG03.
TMPH-01467	PDE9A Protein, Human, Recombinant (His & Myc)	Human	E. coli
	PDE9A Protein, Human, Recombinant (His & Myc) is expressed in E. coli.
TMPH-03254	PDE1C Protein, Rat, Recombinant (His)	Rat	E. coli
	PDE1C Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 92.6 kDa and the accession number is Q63421.
TMPY-02977	PDE1C Protein, Human, Recombinant (His & GST) hCam-3,phosphodiesterase 1C, calmodulin-dependent 70kDa,cam-...	Human	Baculovirus Insect Cells
	PDE1C belongs to the cyclic nucleotide phosphodiesterase family, PDE1 subfamily. Phosphodiesterases (PDEs) are a family of related phosphohydrolyases that selectively catalyze the hydrolysis of 3' cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or cGMP). They regulate the cellular levels, localization and duration of action of these second messengers by controlling the rate of their degradation. PDEs are expressed ubiquitously, with each subtype having a s...
TMPY-01819	PDE1B Protein, Human, Recombinant (His & GST) PDES1B,phosphodiesterase 1B, calmodulin-dependent,<...	Human	Baculovirus Insect Cells
	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B, also known as Cam-PDE 1B and PDE1B, is a cytoplasm protein that belongs to the cyclic nucleotide phosphodiesterase family and PDE1 subfamily. Phosphodiesterase-1A (PDE1A), Phosphodiesterase-1B (PDE1B), Phosphodiesterase-4B (PDE4B), and Phosphodiesterase-4A (PDE4A) are important regulators of signal transduction in striatum due to their catalysis of cyclic AMP and cyclic GMP. PDE1B is highly expressed in the striatum. It b...

重组蛋白

PDE2A Protein, Human, Recombinant (aa 215-900, His)

Cat.No: TMPY-02081

Species: Human

Expression System: Baculovirus Insect Cells

ALDH7A1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01588

Species: Human

Expression System: E. coli

PDE9A Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-01922

Species: Human

Expression System: Baculovirus Insect Cells

PDE9A Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02706

Species: Mouse

Expression System: E. coli

PDE9A Protein, Human, Recombinant (His)

Cat.No: TMPY-01921

Species: Human

Expression System: E. coli

PDE5A Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02575

Species: Mouse

Expression System: E. coli

PDE9A Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01467

Species: Human

Expression System: E. coli

PDE1C Protein, Rat, Recombinant (His)

Cat.No: TMPH-03254

Species: Rat

Expression System: E. coli

PDE1C Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-02977

Species: Human

Expression System: Baculovirus Insect Cells

PDE1B Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-01819

Species: Human

Expression System: Baculovirus Insect Cells

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